KR20150122812A - 다발성 경화증 치료용 s1p 수용체 조절제 - Google Patents

다발성 경화증 치료용 s1p 수용체 조절제 Download PDF

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Publication number
KR20150122812A
KR20150122812A KR1020157030213A KR20157030213A KR20150122812A KR 20150122812 A KR20150122812 A KR 20150122812A KR 1020157030213 A KR1020157030213 A KR 1020157030213A KR 20157030213 A KR20157030213 A KR 20157030213A KR 20150122812 A KR20150122812 A KR 20150122812A
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South Korea
Prior art keywords
alkyl
substituted
compound
receptor
formula
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KR1020157030213A
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English (en)
Korean (ko)
Inventor
페터 체. 히스탄트
크리스띠앙 슈넬
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노파르티스 아게
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36888144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20150122812(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20150122812A publication Critical patent/KR20150122812A/ko
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020157030213A 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제 Ceased KR20150122812A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0612721.1A GB0612721D0 (en) 2006-06-27 2006-06-27 Organic compounds
GB0612721.1 2006-06-27
PCT/EP2007/005597 WO2008000419A1 (en) 2006-06-27 2007-06-25 S1p receptor modulators for treating multiple sclerosis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147010290A Division KR20140069178A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020177034918A Division KR20170138583A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제

Publications (1)

Publication Number Publication Date
KR20150122812A true KR20150122812A (ko) 2015-11-02

Family

ID=36888144

Family Applications (6)

Application Number Title Priority Date Filing Date
KR1020157030213A Ceased KR20150122812A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제
KR1020217001928A Ceased KR20210010956A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제
KR1020177034918A Ceased KR20170138583A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제
KR1020097001390A Withdrawn KR20090024281A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제
KR1020147010290A Withdrawn KR20140069178A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제
KR1020197007465A Ceased KR20190030776A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제

Family Applications After (5)

Application Number Title Priority Date Filing Date
KR1020217001928A Ceased KR20210010956A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제
KR1020177034918A Ceased KR20170138583A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제
KR1020097001390A Withdrawn KR20090024281A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제
KR1020147010290A Withdrawn KR20140069178A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제
KR1020197007465A Ceased KR20190030776A (ko) 2006-06-27 2007-06-25 다발성 경화증 치료용 s1p 수용체 조절제

Country Status (20)

Country Link
US (3) US20100168078A1 (enExample)
EP (4) EP2698154A1 (enExample)
JP (8) JP2009541386A (enExample)
KR (6) KR20150122812A (enExample)
CN (2) CN101478961B (enExample)
AU (7) AU2007264031C1 (enExample)
BR (1) BRPI0713985A2 (enExample)
CA (1) CA2653569C (enExample)
DE (1) DE15177166T1 (enExample)
DK (1) DK2959894T3 (enExample)
ES (1) ES2887042T3 (enExample)
GB (1) GB0612721D0 (enExample)
HU (1) HUE059922T4 (enExample)
LT (1) LT2959894T (enExample)
MX (3) MX2008016133A (enExample)
PL (1) PL2959894T3 (enExample)
PT (1) PT2959894T (enExample)
RU (1) RU2617502C2 (enExample)
SI (1) SI2959894T1 (enExample)
WO (1) WO2008000419A1 (enExample)

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AU2019219818A1 (en) 2019-09-12
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US9187405B2 (en) 2015-11-17
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