KR20150114271A - Toothpaste composition including stone cell of pear fruit - Google Patents

Abstract

The present invention relates to a toothpaste composition including brachysclereids. According to a variety of embodiments of the present invention, the toothpaste composition, which includes brachysclereids as an abrasive, can reduce costs or prevent abrasion on enamel or dentin when using chemical components or walnut shell powder as an abrasive. In addition, the toothpaste composition not only can control abrasion, depending on the size of the brachysclereids, but also can enhance safety and usability as a natural material.

Description

Toothpaste composition including a stone cell of pear fruit [

The present invention relates to a dentifrice composition dentifrice composition comprising a dolomite cell having a polishing effect and a plaque removal effect.

In recent years, Korea has become a major breeding area that occupies more than 16% of the whole fruit growing area in a short period of time due to the conversion of other crops such as water, which has relatively low economic efficiency after import liberalization. Oriental stomach has recently been exported to Europe, which is the largest export and import country of the stomach, and the characteristics of oriental stomach which can be consumed in juice and raw meat have become known, and consumers prefer soft, juicy stomach to medium and small stomach and texture. Especially, it is known that a ship having a lot of hard stone cells composed of lignin and cellulose is strong in the texture of fruit. Studies on these cells have been carried out in many ways, such as the components of the cells, the timing of formation, and the density of the cells in the flesh. However, the research on the southern type Oriental Pear which is mainly grown in Korea is insufficient.

The stones, called stiffened or posterior wall cells, are shorter in length than fibrous cells and have very hard, irregular secondary cell walls. Stone cells are found in fruit tissues, especially in the pulp of the genus Pyrus. It is known that lignin is a type of lignification in which lignin is deposited on cell walls in tissues, and it is known that it plays a role of strengthening the cell wall and fixing the shape of the cell wall so that it does not change. The major components of the cells in the pear fruit were studied long ago by Ranadive and Haard in the western pear. The main ingredient is lignocellulose, and the content of each ingredient is approximately the same as that of the primary cell wall (carbohydrate, cellulose, hemicellulose , Pectin) 82%, and it was reported that 18-35% of lignin was not contained in the primary cell wall. The main units of lignin are vanillin and syringaldehyde, and carbohydrates are called glucose and xylose.

Toothpaste is a kind of tooth cleaner for removing food residue, bacteria film, etc. attached to teeth, and it is a main purpose to clean mouth and remove bad breath. It is effective to prevent tooth decay by transmitting effective ingredients for tooth decay, It also makes white. Toothpaste has a low viscosity liquid type and a high viscosity paste type and powder type, but mainly paste type is preferred and it is used in a tube.

Toothpaste is an abrasive that physically removes the debris on the teeth, a surfactant that helps to effectively remove the stuck residue, an excipient that helps maintain proper viscosity, an excipient that helps maintain shape, A moisturizing agent as a main component, and an additive such as a fragrance, a sweetener, an antiseptic, a coloring agent and the like to suit the taste of a consumer.

The role of the abrasive for toothpaste is that the abrasive is used to physically remove the dirt on the surface of the tooth, but also the abrasion of the abrasive is important because the enamel and dentin of the tooth can be abraded. If the surface of the tooth is easily cleaned Toothpastes that can be widely applied to children and adolescents as well as adults who have a lot of teeth and calculus, such as toothpastes with high wear and low toothpaste, .

Typical abrasive agents are calcium monoxide, precipitated calcium carbonate, silica and insoluble meta-oxygen. These abrasives have higher hardness than carbonate apatite, which is a component of tooth enamel. The dentin is exposed at the thin part of the enamel at the border of the gum, and the gum is swollen and the pain is felt. In addition, currently used abrasives have an average particle size of 10 to 30 占 퐉, and therefore, in order to perform effective polishing, the addition amount of 40% or more by weight must be high and the brushing time must be increased.

In order to solve the above-mentioned problems, a toothpaste composition containing natural products has been developed. For oral compositions such as toothpastes developed in the past, KR10-2010-003429 contains green tea extract, walnut extract , Horse riding extract, and myrrh extract to prevent tooth decay and prevent gum disease. However, in the case of walnut shell powder, the surface of the walnut shell powder is very rough and the frizzy of the tooth may be worn out , The walnut shell powder is mostly dependent on the import, and therefore, there is a problem that a high cost is required when it is used for polishing.

KR10-2004-0054317 discloses a dentifrice composition comprising a vegetable abrasive obtained by lyophilizing components including fibers of leaf, stem and fruit skin of a plant, pulverizing the pulverized fiber powder into a starch solution or polymer, However, the above-described vegetable abrasive alone can not significantly improve the polishing effect, and therefore, it is required to include an abrasive composed of chemical components such as silica, potassium carbonate, sodium hypochlorite, calcium monohydrogenphosphate and alumina.

In addition, a dentifrice composition including the green tea toothpaste composition disclosed in KR10-2005-0082688, the loess soil and the pine needle extract disclosed in KR10-2006-0092508 has been developed. However, as described above, the dentifrice composition containing a natural product has also problems to be solved , It is necessary to develop a toothpaste abrasive which can be widely applied not only to normal persons but also to children and adolescents with a soft tooth age, and patients with severe tooth wear.

A problem to be solved by the present invention is to provide a method for producing a large amount of stevia cells, which comprises a large amount of arbutin, which is a whitening substance, and which has 30 to 60 days after flowering, It is intended to provide a dentifrice composition having a polishing effect and a plaque removing effect by replacing calcium carbonate or walnut shell powder used as a polishing agent for toothpaste.

According to a representative aspect of the present invention, there is provided a dentifrice composition comprising an abrasive and a detergent, wherein the abrasive is a young blight powder or a heated batter powder.

According to various embodiments of the present invention, a dentifrice composition containing a dolomite cell as an abrasive agent solves the problem that a chemical ingredient or a walnut shell powder is used as an abrasive in the past, it is expensive, and enamel or dentin can be worn And it has an advantage that the degree of polishing can be controlled according to the size of the cells, and the stability and feeling of use can be improved with a natural product.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an SEM micrograph of precipitated carbonated particles, silicon dioxide particles, walnut shell particles and bovine cell particles according to embodiments of the present invention. FIG.
FIG. 2 is a SEM electron micrograph of heated bacillus, clear bacillus, and stool cell particles of a juvenile embryo according to an embodiment of the present invention.
FIG. 3 is a graph comparing abrasive efficacy according to an embodiment of the present invention with toothpaste containing a dolomite cell, toothpaste containing a walnut shell, and commercial toothpaste.
FIG. 4 is a view showing a result of measuring the roughness of a tooth surface using a three-dimensional shape measuring device according to an embodiment of the present invention, in which toothpaste containing a dolomite cell, toothpaste containing a walnut shell, and commercial toothpaste are used.
FIG. 5 is a view showing the result of measurement of tooth surface shape by an electron microscope according to the embodiment of the present invention, in which toothpaste containing bone cells, toothpaste containing a walnut shell, and commercial toothpaste are used.

Hereinafter, various aspects and various embodiments of the present invention will be described in more detail.

In this specification, the term 'toothpaste' refers to a preparation for the purpose of whitening and strengthening the teeth and for cleaning the teeth, teeth, gums and oral diseases. The toothpaste is a powder, cream or liquid quasi-drug it means. Common ingredients of common toothpastes include abrasives that grind and polish the surface of the teeth, wetting agents that prevent toothpaste from solidifying, and detergents such as soap that strips off the teeth.

According to one aspect of the present invention, there is provided a dentifrice composition comprising an abrasive and a detergent, wherein the abrasive composition comprises an abrasive and a detergent, wherein the abrasive comprises 30-60 Disclosed is a dentifrice composition characterized by comprising a mesh sized heating powder.

According to one embodiment of the present invention, the toothbrush abrasive comprising the young blight powder or the heated batter powder of the present invention is a natural abrasive, which is harmless to the human body, has excellent stability over time, has high polishing effect such as removal of plaque and tartar great. In addition, the bleaching cell of the present invention has excellent water absorption capacity, but is insoluble in water. In the case of the abrasive composition of the conventional toothpaste, the bleaching agent is diluted when it comes into contact with water, It is possible to solve the problems, and thus it can be usefully used as a dentifrice composition.

Meanwhile, according to one embodiment of the present invention, the collection time of the young blight powder used as an abrasive material is very important. Although the young blight collected 30-60 days after full bloom of the blossom flower is the most abundant albutine content, It is more preferable to use young blast powder among young blast powder and heated blast powder since it is in a state before pesticide is cultivated in pear cultivation and is excellent in stability.

In one embodiment of the present invention, the juvenile powder or heated powder is contained in an amount of 5-15% by weight based on the total weight of the composition.

If the amount is less than 5% by weight, the polishing effect may be poor. If the amount is more than 15% by weight, the tooth surface may be excessively polished.

On the other hand, the young or powdery powder to be added to the dentifrice composition is all or a part of the above-mentioned abrasive powder, and the young blight powder contains 40-60% by weight of bedrock cells independently of each other, And 15-20% by weight of the dentifrice composition. The dentifrice composition is characterized in that the whole of the powdery mildew or the dried powder of 30-60 mesh size is ground to 700-1000 mesh.

When the particle size is less than 700 mesh, there may be a problem that foreign particles are generated at the mouth when the particles are large as a dentifrice preparation, and when the particle size exceeds 1000 mesh, the efficacy as an abrasive agent may be reduced.

In another embodiment of the present invention, the heat-treated powder has a lightness of 60.2-65.4.

On the other hand, in general, the batter powder containing bacillus cells can be selected by preparing a juice, drying the resulting bacillus and pulverizing it, and then using a desired size.

In the heat-treated powder of the embodiment of the present invention, the pear is heated at 110-120 ° C under high pressure for 2-4 hours, filtered twice with a nonwoven fabric, and the pellet-free by-product is dried by hot air drying at 50-80 ° C for 3-12 hours , Preferably at 60 DEG C for 9 hours.

In the dentifrice composition, conventional surfactants can be used as a detergent. Such detergent functions to prevent foreign substances separated from the surface of the tooth from being stuck to the surface of the tooth again when the teeth are pushed, and to discharge the tooth completely out of the oral cavity when brushing teeth. Examples of such cleaning agents include alkylsulfates, olefin sulfonates, monoglyceride sulfonates Nonionic surfactants such as anionic surfactants and polyoxyethylene sorbitan fatty acid esters, polyoxyethylene castor oil, glycerin fatty acid esters, alkylolamides, and the like, and amphoteric surfactants such as pluronic F-108 and the like And can be purchased and used commercially.

All of these detergents are exemplarily listed, and a wide variety of detergents having an interfacial activity other than these may also be used in the present invention. In addition to the abrasive and other active ingredients, there are excipients which are used for shaping such as increasing amount or paste, which means 'orally acceptable carrier', which can be easily purchased and used by those skilled in the art.

The dentifrice composition may further include a tooth decay component comprising xylitol, a fluorine compound, or a mixture of two or more thereof in an amount of 0.1 to 5% by weight based on the total weight of the dentifrice composition. The xylitol is obtained from a natural substance such as a birch extract, and is known to be effective in preventing tooth decay by suppressing the propagation of germs without containing sugar while imparting a sweet taste. The xylitol may also be used as a sweetening agent. Fluoride compounds have also been known to have an effect on tooth decay for a long time and are known to those skilled in the art so that they can be easily purchased and used. When the dental caries preventive component is contained in an amount of less than 0.1% by weight based on the total weight of the dental composition, it is difficult to expect a dental caries prevention effect. If the dental caries prevention ingredient exceeds 5% by weight, Can be.

In order to prevent periodontal disease, aminocaproic acid, allantoin, allantoin derivatives and various vitamins having high osmotic pressure and water-soluble salts such as sodium hydrogen carbonate and sodium hydrogen carbonate and hemostatic action can be used at the same time.

The dentifrice composition may further contain auxiliary ingredients such as other wetting agents, binders, foaming agents, sweeteners, flavoring agents, coloring agents or a mixture of two or more thereof in an amount of 0.1 to 50% by weight based on the total weight of the dentifrice composition. These wetting agents, foaming agents, sweeteners, flavoring agents, and coloring agents are also those that can be easily understood by those skilled in the art of manufacturing toothpaste. Further, titanium dioxide or the like may be used for improving whitening. If the auxiliary components are contained in an amount of less than 0.1% by weight based on the total weight of the dentifrice composition, there may be a problem that it is difficult to form an appropriate toothpaste by these auxiliary components. On the other hand, There may be a problem causing a shortage of components.

The wetting agent contained in the dentifrice composition of the present invention is a base component that is essential for making a dentifrice formulation. The dentifrice composition prevents the dentifrice from being dried and solidified when exposed to air and provides gloss to the surface of the dentifrice. . In the dentifrice composition of the present invention, at least one selected from concentrated glycerin (98%), glycerin (85%), sorbitol aqueous solution (70%), amorphous sorbitol aqueous solution (70%), polyethylene glycols and propylene glycol .

The binder serves to separate the solid powder component from the liquid component. Any water-soluble polymer can be used, and examples of commonly used components include carboxymethyl cellulose sodium synthesized from cellulose of wood, carrageenan extracted from seaweed, and xanthan gum obtained from the metabolism of microorganisms .

The foaming agent improves the feeling of use of the product, assists the cleansing action, expedites dispersion and penetration of other active ingredients, and reduces the interfacial tension, thereby easily releasing foreign substances in the oral cavity. As the foaming agent, a copolymer of anionic surfactant such as sodium lauryl sulfate, polyoxyethylene-polyoxypropylene (poloxamer), polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester and the like can be used.

In addition to the above components, fragrances, sweeteners, colorants and the like can be used in order to improve the feeling of use. For the fragrance used for this purpose, it is necessary to use edible fragrance that can be eaten. Sodium saccharin and stevioside are used as sweeteners, and it is preferable to use food coloring as a coloring matter.

In another embodiment of the present invention, the dentifrice composition is any one selected from among dentifrice compositions for children, dentifrice compositions for adults, dentifrice compositions for syringes, dentifrice compositions for pregnant women, and dentifrice compositions for diabetics.

In another embodiment of the present invention, the dentifrice composition is any one selected from the group consisting of a liquid type, a cream type, a powder type, a paste type, and a transparent gel type.

In another embodiment of the present invention, the dentifrice composition is characterized by exhibiting a polishing effect and a purging effect.

Hereinafter, the present invention will be described in more detail with reference to Examples and the like, but the scope and content of the present invention can not be construed to be limited or limited by the following Examples. In addition, it is apparent that, based on the teachings of the present invention including the following examples, those skilled in the art can easily carry out the present invention in which experimental results are not presented specifically.

Manufacturing example  1: clear Exhaustion  Preparation of powder

The clear powder was heated at 80-90 ° C for 30 minutes to 2 hours, and then filtered through a nonwoven fabric three times to prepare a juice. Lightness was 80.2-87.8 as a by-product. , And this was called a clear batter powder.

Manufacturing example  2: Heating Exhaustion  Preparation of powder

The heating powder was heated at 120 ° C. for 2 to 4 hours at a temperature of 120 ° C. and filtered twice with a nonwoven fabric to prepare a juice. The lightness was 60.2-65.4 as a by-product, It was called an abrasive powder.

Manufacturing example  3: Young ship  Preparation of powder

Young fruit powder is obtained by grinding a pear taken 30-60 days after full bloom and removing moisture by hot air drying (50-80 ° C, 3-12 hours, preferably 60 ° C, 9 hours) Lightness was 50.2-55.4 and was referred to as juvenile powder.

Experimental Example  1: heating Exhaustion  Powder, clear Exhaustion  powder, Young ship  Investigation of moisture absorption of powder

As shown in the following Table 1, the amount of water absorption according to the type of batter and the size of powder according to the present invention was measured.

Investigation of moisture absorption of clear batter powder, heated batter powder and juvenile powder division
(Size of batter powder by type of batter) Moisture absorption time 0 h 1 h 2 h 3 h 6 h 24 h 48 h 72 h One Clear exhaust powder
Before separation 2.97 ^b 3.61 ^a 3.91 ^a 3.98 ^a 4.12 ^a 4.21 4.26 ^a 4.29 ^a 2 Clear exhaust powder
30-60 mesh 2.29 ^c 2.61 ^c 2.80 ^b 2.81 ^c 2.92 ^d 3.14 3.15 ^d 3.27 ^c 3 Clear exhaust powder
60-80 mesh 3.32 ^a 3.42 ^b 3.40 ^ab 3.40 ^b 3.53 ^c 3.7 3.81 ^c 3.93 ^b 4 Clear exhaust powder
80-150 mesh 3.50 ^a 3.64 ^a 3.70 ^a 3.79 ^ab 3.86 ^b 3.87 4.11 ^b 4.37 ^a 5 Heated batter powder
Before separation 2.81 ^b 2.98 ^a 3.01 ^b 3.37 ^a 3.45 ^b 3.45 ^b 3.52 ^b 3.73 ^b 6 Heated batter powder
30-60 mesh 2.23 ^c 2.45 ^b 2.48 ^c 2.50 ^c 2.51 ^d 2.53 ^c 2.58 ^c 2.61 ^c 7 Heated batter powder
60-80 mesh 2.86 ^b 2.90 ^a 2.94 ^b 3.04 ^b 3.27 ^c 3.38 ^b 3.44 ^b 3.59 ^b 8 Heated batter powder
80-150 mesh 3.02 ^a 3.14 ^a 3.34 ^a 3.61 ^a 3.78 ^a 3.92 ^a 3.98 ^a 4.19 ^a 9 Young pear powder
Before separation 1.34 1.39 ^bc 1.40 ^c 1.41 ^c 1.43 ^c 1.47 ^c 1.51 1.54 ^c 10 Young pear powder
30-60 mesh 1.31 1.36 ^c 1.37 ^c 1.43 ^c 1.47 ^c 1.48 ^c 1.55 1.64 ^b 11 Young pear powder
60-80 mesh 1.44 1.48 ^b 1.52 ^b 1.53 ^b 1.56 ^b 1.59 ^b 1.6 1.69 ^b 12 Young pear powder
80-150 mesh 1.59 1.62 ^a 1.66 ^a 1.67 ^a 1.70 ^a 1.74 ^a 1.76 1.87 ^a

As shown in Table 1, the water absorption capacity according to the type of batter and the size of batter powder containing brittle cells of the present invention was examined. As a result, it was found that the size of the heated batter powder was 30-60 mesh, Showed that water absorption was not increased with time, especially when the cell size was 30-60 mesh, the water absorption capacity did not increase for 72 hours. On the other hand, The increase of the water absorption capacity was confirmed.

Experimental Example  2: Heating Exhaustion  Powder, clear Exhaustion  powder, Young ship  Contained in the powder Stone cell  Content ratio

As shown in the following Table 2, the content of the cells of the present invention was investigated according to the type of batter and the size of powder according to the present invention. Bacillus cells were dissolved in 0.1 M NaCl, dried in dehydrated scale, treated with 0.1 N NaOH and 0.5 N HCl in that order, and then dried.

The ratio of the content of stones in the heated batter, clear batter powder, young pear powder Size of batter powder Percentage (%) Stone cell amount
(g / 100 g) * Amount of cells in bone
(g / 100 g) One Clear exhaust powder
Less than 30 mesh 15.1 28.7 4.3 2 Clear exhaust powder
30-60 mesh 26.2 42.8 11.2 3 Clear exhaust powder
60-80 mesh 16.8 35.3 9.2 4 Clear exhaust powder
More than 80 mesh 41.9 24.1 6.3 5 Clear exhaust powder
all 100.0 130.9 31.1 6 Heated batter powder
Less than 30 mesh 14.0 23.5 4.3 7 Heated batter powder
30-60 mesh 46.7 69.3 18.2 8 Heated batter powder
60-80 mesh 29.7 45.7 12.0 9 Heated batter powder
More than 80 mesh 9.6 30.9 8.1 10 Heated batter powder
all 100.0 169.4 42.5 11 Young pear powder
Less than 30 mesh 36.3 67.6 4.3 12 Young pear powder
30-60 mesh 41.8 72.7 19.0 13 Young pear powder
60-80 mesh 16.7 57.8 15.1 14 Young pear powder
More than 80 mesh 5.3 42.1 11.0 15 Young pear powder
all 100.0 240.2 49.5

* Indicates the cell content of stones contained in 100 g of powder separated by size in vacuum dried powder.

As shown in Table 2 above, the content of the stomata cells was found to be about 31% in the whole clear powder, while about 43% in the case of the whole heat-dried powder, As described above, when the size of the heated batter powder is 30-60 mesh and the size of the bovine cells of all sizes of the juvenile powder is absorbed with time, And it was judged that it is preferable to use it as a toothpaste abrasive material.

Experimental Example  3: SEM  Electron microscope Scrub  Comparison of materials structure

The structures of abrasive cells (9-11 ㎛), silicon dioxide (9-11 ㎛), walnut shells (20-30 ㎛) and gypsum cells according to the present invention, which are mainly used in the market, were analyzed by FE-SEM electron microscopy. The distribution of the particle size was investigated by proceeding the sieve analysis by size, and the shape of the particles was determined by separating the boll cells contained in the blanched powder samples using an electron microscope (JSM-7500F, JEOL) The 30-60 mesh powder of the powder was heated and crushed to a size of 160 mesh by a plate mill, and finely crushed to 800 mesh using ACM (air classifying machines). The results are shown in Fig. 1 and Fig.

As shown in FIG. 1, the brittle cells contained in the batter powder samples according to the present invention have a surface roughness that is similar to that of precipitated carbonic acid, silicon dioxide, and walnut shells, but are low in surface roughness when used as a toothpaste abrasive. It can be used effectively as a dentifrice polishing agent because it has a high polishing effect without abrading.

As shown in FIG. 2, as a result of the structural analysis of the heating batter, the clear batter powder and the young boar powder, 30-60 mesh powder and 30-80 mesh powder of the heating batter were all the most abrasive composition .

Example  1 to 4 and Comparative Example  1 to 3: Preparation of opaque toothpaste containing bacillus cells

5% by weight (Example 2), 10% by weight (Example 3), 15% by weight (Example 4), and 0% by weight of brittle cells (Comparative Example 1), 20% by weight (Comparative Example 2) and 5% by weight of a walnut shell (Comparative Example 3) were added. The content of the rest of the cells except precipitated cells or walnut shells was adjusted to include precipitated calcium carbonate, As shown in Fig. 3, the opaque toothpaste was prepared by a common method for manufacturing toothpaste including the remaining components necessary for toothpaste composition except the abrasive.

efficacy Toothpaste active ingredient Content (% by weight) standard chief ingredient Calcium hydrogen phosphate 0.01-0.10 pharmacopoeia Mechanism Diisorbitol 1-50 pharmacopoeia Mechanism Propylene glycol 1-10 pharmacopoeia Mechanism Concentrated glycerin 1-10 pharmacopoeia Mechanism PEG1500 0.1-1.0 pharmacopoeia  Viscosity modifier Sodium carboxymethylcellulose sodium 0.5-5.0 Food Foaming agent Sodium lauryl sulfate 1-10 pharmacopoeia Incrementer Xanthan gum 1-10 Food antiseptic Sodium benzoate 0.1-1.0 Food Sweetener Green tea extract 0.01-0.10 pharmacopoeia Sweetener Jalal recall 0.01-0.10 Food Sweetener Chitosan 0.01-0.10 Food Sweetener Propolis extract 0.01-0.10 Other Flavoring agent DL-menthol Suitable amount Food Flavoring agent Pepamine Suitable amount Rain solvent Purified water Suitable amount pharmacopoeia

Examples 5 to 8 and Comparative Examples 5 to 7: Preparation of a transparent toothpaste containing bacillus cells

The toothpaste was prepared in the same manner as in Example 1, except that silicon dioxide was used instead of precipitated calcium carbonate in Examples 1 to 4 and Comparative Examples 1 to 3.

Experimental Example 4: Measurement of quality characteristics and moisture absorption index of opaque toothpaste and transparent toothpaste containing bone cells

The quality characteristics and water absorption index of the opaque toothpaste and transparent toothpaste containing the dolicho cells according to the present invention are shown in Tables 4 to 7 below. Hereinbelow, the opaque toothpaste of Comparative Example 4 used for commercial use was a corduroy toothpaste (Shinwha Pharm), and the transparent toothpaste of Comparative Example 8 was a toothpaste echocard organic toothpaste (Amorepacific).

Quality Characteristics of Opaque Toothpaste Containing Bone Cells division Stickiness
(g.Sec) Moisture content
(%) pH importance
(g / mL) Chromaticity L a b Example 1 Vesicular cell
3 wt% 61.4 27.91 8.54 1.26 66.3 4.4 12.4 Example 2 Vesicular cell
5 wt% 63.6 27.39 8.45 1.24 63.6 5.7 13.7 Example 3 Vesicular cell
10 wt% 143.8 27.30 8.29 1.23 55.2 5.9 16.6 Example 4 Vesicular cell
15 wt% 507.6 28.48 8.14 1.21 50.4 7.0 17.5 Comparative Example 1 Vesicular cell
0 wt% 45.0 25.50 8.57 1.32 69.7 3.6 11.1 Comparative Example 2 Vesicular cell
20 wt% 2.4 25.63 8.01 1.20 49.0 7.6 18.3 Comparative Example 3 Walnut shell
5 wt% 84.8 63.25 8.44 1.22 60.5 4.2 15.3 Comparative Example 4 Commercial 113.1 55.71 8.84 1.23 55.7 72.9 13.5

The moisture absorption index of opaque toothpastes containing bone cells division Water Absorption Rate (%) 0 h 1 h 3 h 6 h 24 h Example 1 Vesicular cell
3 wt% 120 127 129 156 143 Example 2 Vesicular cell
5 wt% 142 144 150 180 165 Example 3 Vesicular cell
10 wt% 166 174 172 203 175 Example 4 Vesicular cell
15 wt% 171 181 186 199 197 Comparative Example 1 Vesicular cell
0 wt% 135 139 149 166 151 Comparative Example 2 Vesicular cell
20 wt% 178 184 186 201 198 Comparative Example 3 Walnut shell
5 wt% 143 151 151 162 160 Comparative Example 4 Commercial 120 128 143 157 146

Quality Characteristics of Transparent Toothpaste Containing Bacillus Cells division Stickiness
(g.Sec) Moisture content
(%) pH importance
(g / mL) Chromaticity L a b Example 5 Vesicular cell
3 wt% 145.3 27.9 6.96 1.14 67.1 2.26 12.9 Example 6 Vesicular cell
5 wt% 136.1 28.5 6.86 1.08 63.9 4.07 16.5 Example 7 Vesicular cell
10 wt% 134.5 27.9 6.68 1.07 61.4 5.67 18.7 Example 8 Vesicular cell
15 wt% 79.1 27.6 6.44 1.05 60.5 6.14 19.1 Comparative Example 5 Vesicular cell
0 wt% 150.4 27.7 7.09 1.18 72.4 0.32 7.4 Comparative Example 6 Vesicular cell
20 wt% 47.2 27.4 6.30 1.04 59.8 6.56 19.0 Comparative Example 7 Walnut shell
10 wt% 102.0 28.5 7.04 1.14 60.8 5.05 17.6 Comparative Example 8 Commercial 66.9 61.9 6.75 1.31 34.9 0.70 0.3

The moisture absorption index of transparent toothpaste containing bacillus cells Water Absorption Rate (%) 0 h 1 h 3 h 6 h 24 h Example 5 Vesicular cell
3 wt% 107.7 109.4 110.9 130.2 129.8 Example 6 Vesicular cell
5 wt% 132.1 136.7 136.9 173.2 139.4 Example 7 Vesicular cell
10 wt% 125.4 128.5 128.3 147.6 134.6 Example 8 Vesicular cell
15 wt% 130.7 139.3 142.6 149.8 146.3 Comparative Example 5 Vesicular cell
0 wt% 102.5 103.8 120.5 167.9 137.4 Comparative Example 6 Vesicular cell
20 wt% 133.3 133.7 135.7 151.3 140.3 Comparative Example 7 Walnut shell
10 wt% 108.9 115.4 117.1 119.3 119.1 Comparative Example 8 Commercial 102.9 107.6 124.8 168.1 137.1

As shown in Tables 4 to 7, when evaluating the toothpaste quality characteristics and comparing the water absorption rates, it was found that when the content of bray cells according to the present invention is 5 wt%, 10 wt% and 15 wt%, the toothpaste containing the conventional walnut shell , But it was confirmed that it was superior in quality and water absorption than commercial toothpaste. Particularly, when the content of bacillus cells was 5 wt% and 10 wt%, it was confirmed that the water absorption capacity was very excellent, which can shrink the volume during long-term storage of the toothpaste and can secure the disadvantage that the tooth paste paste flows have.

Experimental Example  5: Sensory Evaluation of Opaque Toothpaste and Transparent Toothpaste Containing Bone Cells

The preference of the toothpaste containing the bone cells according to the present invention was examined.

Ten subjects (male mean age: 33.8 years, female mean age: 37.0 years) who were healthy adults without gum disease were trained on the purpose of the experiment and the evaluation method. Was evaluated as follows. First, the subjects were instructed on the proper brushing method, and then the toothpaste of Examples and Comparative Examples was distributed to each subject. Brushing was performed three times a day for two weeks in the same manner as usual, and then evaluated for use with the control group.

At this time, the sensory test score was 9 points scale (9 points - excellent, 7 points - excellent, 5 points - average, 3 points - less than normal, 1 point - no effect) for the improvement of tooth cleanliness in the examples and comparative examples, , And the results of calculating the average value for each evaluation are shown in Tables 8 and 9 below.

Opacity toothpaste containing bacillus cells division Exterior Brittle Oral
Refreshing feeling Bad breath
Removal degree Sustainability all
preference Example 1 Vesicular cell
3 wt% 5.87 6.25 6.87 6.62 7.12 6.50 Example 2 Vesicular cell
5 wt% 7.25 7.37 7.87 7.5 7.25 7.75 Example 3 Vesicular cell
10 wt% 7.25 6.75 7.12 6.75 7.12 7.12 Example 4 Vesicular cell
15 wt% 6.37 6.62 7.00 6.75 7.12 6.50 Comparative Example 1 Vesicular cell
0 wt% 6.37 6.75 7.37 7.25 7.50 6.37 Comparative Example 2 Vesicular cell
20 wt% 4.53 5.23 5.00 5.45 5.64 6.00 Comparative Example 3 Walnut shell
10 wt% 6.75 6.56 7.12 6.87 6.75 7.12 Comparative Example 4 Commercial 7.10 7.30 7.27 7.20 7.10 7.30

Preference for transparent toothpaste containing bacillus cells division Exterior Brittle Oral
Refreshing feeling Bad breath
Removal degree Sustainability all
preference Example 5 Vesicular cell
3 wt% 6.78 7.33 5.89 6.44 6.44 6.56 Example 6 Vesicular cell
5 wt% 7.44 6.89 6.44 6.44 6.56 7.02 Example 7 Vesicular cell
10 wt% 7.56 7.00 6.56 7.44 7.00 7.44 Example 8 Vesicular cell
15 wt% 7.44 6.89 6.44 6.44 6.56 7.02 Comparative Example 5 Vesicular cell
0 wt% 6.89 6.89 5.78 6.67 6.00 6.22 Comparative Example 6 Vesicular cell
20 wt% 6.78 6.89 7.00 7.11 7.22 6.78 Comparative Example 7 Walnut shell
10 wt% 6.44 7.00 7.33 7.22 7.44 6.78 Comparative Example 8 Commercial 7.10 7.30 7.28 7.20 7.10 7.30

As shown in Tables 8 and 9, it was confirmed that the use feeling of toothpaste containing brittle cells according to the present invention was evaluated to be higher than that of commercially available toothpaste and toothpaste containing a walnut shell. In particular, toothpastes containing 5 wt% to 15 wt% of a powder containing a powder of heating powder or a powder containing 30-60 mesh of brittle granules are superior to commercially available toothpastes in terms of dripping, mouthfeel, It is superior because it has high preference and can be used effectively as toothpaste containing bacillus cells.

Experimental Example  6: Abrasive effect of toothpaste containing bacillus cells

In order to investigate the abrasive effect of bamboo toothpaste containing abalone cells, 20 teeth of less than 18 months old were sampled, and teeth were sampled and tested by 3D-OP apparatus to select teeth and regions with similar roughness Respectively.

In order to carry out the experiment, 35% by weight of precipitated calcium carbonate as a basic abrasive was added to the toothpaste, and the abrasive reinforcing toothpaste decreased the amount of precipitated calcium carbonate and 5% by weight, 10% by weight or 5% by weight of the walnut shell powder according to the present invention % Were added to the toothpaste. The commercial toothpaste containing the walnut shell powder as an abrasive was used as a positive control.

After cutting the teeth with a cutting machine, spread a 10 g sample of toothpaste thinly on a satin nonwoven with a spatula. The area of the tooth to be tested was indicated by 1 ㅧ 1 cm, followed by 300 reciprocating brush strokes of about 50 lines per minute. The polishing method was investigated by modifying the conditions according to the British dental journal (Vol. 133 (60), 1972 by H. ASMORE et al.).

The instrument used was made directly by Brushing M / C. After removing the specimen tooth slice from the specimen tooth slice fixture, the worn surface was fixed with rubber clay to measure with a three-dimensional shape measuring instrument (Nanosurface 3D Optical Profiler) The effect of the abrasive was evaluated by comparing the roughness of the abrasive before and after abrasive use through Ra (arithmetic average roughness within the reference area). The results are shown in Table 10 and Figs. 3 to 4.

Abrasive effect Abrasive type Ra (A) average before polishing After polishing
Ra (B) Average asperity
Ra (AB) grinding
effect(%) Example 2 Vesicular cell
5 wt% 6.92 4.41 2.51 36.3 ^b Example 3 Vesicular cell
10 wt% 6.93 3.33 3.60 52.2 ^a Comparative Example 1 Vesicular cell
0 wt% 7.71 6.82 0.89 11.5 ^e Comparative Example 3 Walnut shell
5 wt% 6.49 5.03 1.46 22.5 ^c Comparative Example 4 Commercial 6.93 5.64 1.29 20.3 ^d

As shown in Table 10 and FIG. 3 to FIG. 4, the abrasive effect was compared. As a result, it was found that the toothpaste cell toothpaste according to the present invention exhibited tooth polishing effect of 36-52%, which is a toothpaste containing a walnut shell (22.5%) and commercial abrasive toothpaste (20.3%).

Experimental Example  7: Surface shape measurement

In order to investigate the abrasive effect of the toothpaste containing the bone cells according to the present invention, the surface shape of the front teeth of the hydrogen sampled before was examined using an electron microscope before and after brushing.

As shown in Fig. 5, in the case of the toothpaste containing the vascular cell according to the present invention, the surface was smoothly visually confirmed.

Therefore, toothpastes containing the dolomite according to the present invention as an abrasive are excellent in abrasive effect and superior to commercial toothpaste containing a walnut shell, so they can be very useful as abrasive toothpaste.

Claims (8)

A dentifrice composition comprising an abrasive and a detergent,
Wherein the abrasive agent comprises a young blight powder or a 30-60 mesh sized heated batter powder collected 30-60 days after full blossom.
2. The dentifrice composition according to claim 1, wherein the bittern powder or the heated batter powder comprises 5-15% by weight based on the total weight of the composition.
The dentifrice composition according to claim 1, wherein the juvenile powder comprises 40 to 60% by weight of bovine cells.
The dentifrice composition according to claim 1, wherein the heat-disintegrating powder comprises 15-20% by weight of talc cells.
The dentifrice composition according to claim 1, wherein the dentifrice composition includes all of the young blight powder or a 30-60 mesh sizing powder to 700-1000 mesh.
[3] The method of claim 1, wherein the lightness of the powder is 60.2-65.4,
The heat-treated powder is heated by heating at 110-130 ° C for 2-4 hours, filtered with a nonwoven fabric, and dried by hot air drying at 50-80 ° C for 3-12 hours. Toothpaste abrasive.
The dentifrice composition according to claim 1, wherein the dentifrice composition is any one selected from among dentifrice compositions for children, dentifrice compositions for adults, dentifrice compositions for syringes, dentifrice compositions for pregnant women, and toothpaste for diabetic patients.
The dentifrice composition according to claim 1, wherein the dentifrice composition is any one selected from the group consisting of cream, powder, paste, and transparent gel.

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