KR100941670B1 - Oral care Composition using Botanical Abrasive - Google Patents

Abstract

The present invention relates to a toothpaste composition characterized in that the use of a vegetable abrasive, specifically freezing the components comprising the fiber of the leaves, stems, fruit peel of the plant in the range of -35 ℃ to -45 ℃ and the frozen After freeze-drying the plant leaves, stems, and fruit peels at -50 ° C to -55 ° C for 72 to 96 hours, the lyophilized plant leaves, stems, and fruit peels are pulverized and screened to a suitable size. It was developed into a new abrasive with abrasive function by putting it in a solution or polymer and spray drying it into granules with particle size less than 20㎛. The vegetable abrasive of the present invention is excellent in preventing tooth decay, preventing periodontal disease, removing bad breath, whitening effect, and gum massage effect. An oral hygiene composition containing a vegetable abrasive for maintenance.

Vegetable abrasives, toothpaste, freeze drying,

Description

Oral hygiene composition containing vegetable abrasive {Oral care Composition using Botanical Abrasive}

The composition of the present invention has a low abrasiveness with vegetable abrasives (cabbage leaves, green tea leaves, lettuce leaves, pine needles, ginkgo leaves, maple leaves, banana peel grains) to remove plaque without damaging the surface of the teeth and to smooth the gums. It is an oral hygiene-promoting composition that is excellent in preventing tooth decay, preventing periodontal disease, removing bad breath and whitening, and gum massage. More specifically, the components including the fiber of the leaves, stems, and fruit peels of the plant are frozen in the range of -35 ° C to -45 ° C, and the frozen plant leaves, stems, and fruit peels are dried at -50 ° C to -55 ° C. After freeze-drying for 72 to 96 hours, the lyophilized plant leaves, stems, and fruit peels were pulverized and screened to an appropriate size.The selected fibrin powder was placed in a starch solution or polymer and spray-dried to have a particle size of 20 μm or less. Manufactured by granulation, it was developed as a new abrasive with abrasive function. The vegetable abrasive of the present invention is excellent in preventing tooth decay, preventing periodontal disease, removing bad breath, whitening effect, and gum massage effect. Oral care compositions containing vegetable abrasives to retain.

Existing toothpaste abrasives are prepared by blowing carbon dioxide gas into the slurry of slaked lime to control the reaction conditions according to the concentration, reaction temperature, reaction method, presence and absence of additives, and types thereof. After melting, make water glass, settle in sulfuric acid, settle and grind to use as abrasive. Calcium monohydrogen phosphate is prepared by the process of sashimi [CaO], which is a raw material, by calcination of lime, [Ca (OH) 2], and then aging to react with phosphoric acid, crystallization, filtration and hot air drying. It is used to help remove tooth plaque or suppress formation by mechanical activity by mixing wetting agents, binders, drugs, flavors or sweeteners with finely divided abrasives such as hydroxyapatite. Existing abrasives have a hardness of 3 to 8, tasteless odorless, white appearance, insoluble in water, and aim to remove plaque and calculus attached to enamel having a hardness of 6 on the surface of the tooth. Toothpaste using conventional abrasives lacks the massage function, teeth whitening effect and plaque removal ability of gums similar to human skin. Also, toothpaste for infants and children is harmless to the human body when toothpaste is swallowed during daily brushing. Many consumers have raised doubts and concerns about the safety of the human body. In order to improve this phenomenon, the present invention is applied to the toothpaste composition by using pure vegetable leaves, which excludes chemical components, to prevent tooth decay, prevent periodontal disease, remove bad breath, whitening effect and gum massage effect, mineral minerals act on the oral cavity Thus, even if used for a long time, the safety of the human body is higher than that of the conventional abrasive and harmless to the human body provides an oral hygiene composition.

Toothpaste abrasives have been widely used for a long time to prevent tooth decay, periodontal disease, and bad breath. In general, the composition of toothpaste is dispersed in a mixture of 20 to 50% by weight of the abrasive, 20 to 30% by weight of the humectant and a binder, a drug, water and the like. The viscosity of the toothpaste prepared in this way, the initial viscosity immediately after blending is 50,000CPS ~ 100,000CPS, but gradually rises thereafter, and the time-lapse viscosity after one month at room temperature increases to about 100,000CPS ~ 200,000CPS. In this case, depending on the type of abrasive, the toothpaste feeling and foaming power is reduced, and the flavor effect is also changed. In the present invention, by using a vegetable abrasive, there is no damage to the teeth and the mineral mineral contained in the vegetable abrasive acts on the oral cavity, so it is safe for the human body even when used for a long time, and it significantly improves the feeling of brushing teeth, removing bad breath, foaming and gum massage effect. More specifically, the vegetable abrasive is prepared from cellulose fibrous granules. The method of preparing the vegetable abrasive of the present invention includes plant leaves, stems, and fruit peels (cabbage leaves, green tea leaves, lettuce leaves, pine needles, ginkgo leaves). , Maple leaves, banana peel, etc.) freezing in the range of -35 ℃ ~ -45 ℃, and freeze drying the frozen plant leaves and the like at -50 ℃ ~ -55 ℃ 72 to 96 hours, and freezing Pulverizing and drying the dried plant leaves, etc., the powder of the selected plant leaves and the like starch solution (1 ~ 2%) or dextran, 100 ℃ ~ 120 ℃ Sites, boil into 1-2 minutes in Polymer, such as roll cells Oz. At this time, it is coated with starch solution or polymer while dispersing at 3000rmp in Homogenizer. By spraying powders such as plant leaves coated with starch or polymer at 120 ℃ for 2 hours while spraying, they developed a soft abrasive with a new polishing function.

The starch solution used in the present invention is preferably sweet potato, potato, corn starch, and the polymer is preferably dextran, alginate, cellulose.

Chinese cabbage leaf, one of these vegetable leaves, is discarded as a by-product of agricultural products, but its effective use is not established. These are all unused resources, which are easily obtained in powder form and have new functionality having a massage effect and a bad breath removal effect of the gums, and thus, are excellent in economic efficiency and are used as a material of toothpaste abrasives that help environmental conservation. They are excellent in preventing tooth decay, preventing periodontal disease, removing bad breath, whitening and gum massage.

Therefore, a feature of the present invention is to use a natural abrasive and a confirmed vegetable abrasive in the toothpaste composition, the vegetable abrasive of the present invention is about 3 hardness not to damage the enamel, pH is insoluble in water near the neutral, The particle size is 20 µm or less, the thickness is about 2 to 200 nm, and the BET (the specific surface area is generally about 1 to 100 m 2 / g. The BSI (British Standards Institution) polishing degree is British dental journal (Vol 133 (60), 1972 by H. ASMORE etc.) is about 5 to 200.

The composition of the present invention has a low abrasiveness with vegetable abrasives (cabbage leaves, green tea leaves, lettuce leaves, pine needles, ginkgo leaves, maple leaves, banana peel grains) to remove plaque without damaging the surface of the teeth and to smooth the gums. It is an oral hygiene-promoting composition that is excellent in preventing tooth decay, preventing periodontal disease, removing bad breath and whitening, and gum massage. More specifically, the components including the fiber of the leaves, stems, and fruit peels of the plant are frozen in the range of -35 ° C to -45 ° C, and the frozen plant leaves, stems, and fruit peels are dried at -50 ° C to -55 ° C. After freeze-drying for 72 to 96 hours, the freeze-dried plant leaves, stems and fruit peels are pulverized and screened to an appropriate size.The selected fibrin powder is placed in starch solution or polymer and spray-dried to have a particle size of 20 μm or less. It was developed as a new abrasive with abrasive function. The vegetable abrasive of the present invention is excellent in preventing tooth decay, preventing periodontal disease, removing bad breath, whitening effect, and gum massage effect. An oral hygiene composition containing a vegetable abrasive for maintenance.

Existing toothpaste abrasives include calcium carbonate, calcium dihydrogen phosphate, hydrous alumina, silica, sodium bicarbonate, and hydroxyapatite. In the present invention, by developing a vegetable abrasive of the same level as the conventional toothpaste polishing abrasive, it shows the same polishing function as the conventional abrasive and confirmed that the oral hygiene effect is excellent. As a material of the vegetable abrasive, a certain ratio is used by granulating the components including the fiber of the leaves, stems, and bark of the plant. Chinese cabbage, which is used as one of the raw materials of the vegetable abrasive of the present invention, is an edible growing plant having leaves and stems. Green leaves are rich in iron, calcium, chlorophyll, and vitamin C. Yellow algae are rich in vitamin A. Chinese cabbage is good for secretion of saliva, which helps digestion and fever of internal organs. Green tea is an evergreen arboretum or shrub belonging to the genus Aceraceae, whose leaves are long oval, with sharp ends, sawtooth in the ridges, and the quality of the leaves is hard, slightly thick, and the surface is shiny. The active ingredient is the awakening effect of caffeine to excite the sensory center of the cerebral cortex to clear the mind and enhance memory, judgment and endurance. In addition, it helps blood circulation, promotes the smooth operation of the heart, acts as a strong heart, dilates the kidney's blood vessels, diuretic, increases urine volume, removes waste and toxins in the body, and tannins of green tea are alkaloids such as nicotine, mercury, lead, It binds to heavy metals such as cadmium, chromium and copper and releases them to the body, thus detoxifying harmful heavy metals accumulated in the body due to various pollutions. In the method of using green tea with the above ingredients, the fresh leaves of tea are steamed to remove the enzyme's own ability and immediately cooled to fix color and ingredients, and then the tea leaves are softened by hot air drying to remove moisture. Granulates across.

The present invention is composed of conventional components necessary to prepare a composition for promoting oral hygiene, together with a vegetable abrasive using a component containing the fiber of the leaves, stems, fruits of the bark of the plant, the tooth decay while maintaining the proper abrasive force It provides a novel oral hygiene composition that can have a prophylactic and whitening effect.

The composition of the present invention may be used in combination with an appropriate amount of a wetting agent, a binder, a foaming agent, a sweetener, a preservative, a medicinal agent, a flavoring agent, an acidity adjuster, a brightener, and the like, which are commonly used in the vegetable abrasive according to the type and purpose of the composition for oral cavity. have. For example, the toothpaste composition according to the present invention may be used in an amount of 1 to 60% by weight of one or more kinds of abrasives used in vegetable toothpaste alone or as an existing toothpaste as an abrasive. As the humectant, glycerin, sorbitol, amorphous sorbitol solution, propylene glycol, polyethylene glycol, ziitol, and the like are mixed alone or in combination of one or more, and 20 to 60% by weight of the total composition is used. Preferably, glycerin or amorphous sorbitol solution is used. 20 to 50% by weight of propylene glycol or polyethylene glycol in a ratio of 10 to 1 to 1 to 1 by weight ratio, respectively. As the binder, 0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight of carrageenan, xanthan gum, carboxy methyl cellulose sodium, carboxy vinyl polymer, sodium alginate, laponite, or the like may be used alone or in combination. As the foaming agent, anionic surfactants such as sodium lauryl sulfate and sodium lauryl sarcosinate, sorbitan fatty acid esters, polyoxyethylene-cured castor oil, polyoxyethylene, polyoxypropylene-based condensed polymer materials, etc. may be used alone or mixed. To 5.0% by weight, preferably 0.5 to 3.5% by weight. The sweetening agent may be used alone or in one or more types of sodium saccharin, aspartame, licorice acid, etc., and 0.05 to 0.5% by weight. As a preservative, paraoxy benzoic acid ester and sodium benzoate are used individually or in mixture of 1 or more types. Examples of the medicament include sodium fluoride, sodium fluoride phosphate, tin fluoride, amine fluoride, chlorhexidine, tranexamic acid, allantoin, capronic acid, polyphosphate, enzymes and herbal extracts. As a fragrance, peppermint oil, spearmint oil, menthol, carbon and the like are mixed and used in an appropriate amount. Preferably, an anise oil is preferably mixed with an aromatic oil mixed with a predetermined ratio. As the acidity regulator, phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium tartarate, and the like are used, and an appropriate acidity is 5-8. Titanium oxide is used as a brightener, and 0.1 to 1.0% by weight is suitably used. In particular, the oral hygiene-promoting composition according to the present invention uses a mixture of vegetable abrasives containing fiber in a certain ratio, so that the plaque removal effect, the whitening effect, and the toothpaste for people with worn teeth may be used in toothpaste and children's toothpaste. Hereinafter, the present invention will be described in detail based on examples and comparative examples of toothpaste which is the most common formulation, but the technical scope of the present invention is not limited to these examples.

Preparation Example: Method for Preparing Vegetable Abrasives Using Chinese Cabbage Leaves

Prepare starch solution. 99.0 grams of distilled water in 1.0 grams of starch, boiled at 100 ℃ for 1 to 2 minutes and then cooled to room temperature. After freezing dried components of cabbage leaves and stem fiber in the range of -35 ℃ ~ -45 ℃ and freeze-dried the frozen cabbage leaves, stems at -50 ℃ ~ -55 ℃ 72 to 96 hours , Freeze-dried cabbage leaves, stalks are pulverized to a suitable size, the selected fibrin powder is put into the starch solution and dispersed at 3000rpm in a Homogenizer so that the starch solution is coated on the cabbage leaf powder. At this time, the spray drying temperature is 120 ℃ to produce a particle size of less than 20㎛ granules to produce an abrasive with a new polishing function.

Examples 1-4 and Comparative Examples 1-4

Toothpaste compositions of Examples and Comparative Examples were prepared with the components and composition ratios shown in Table 1 below. Powder components such as carboxymethyl cellulose sodium, saccharin, and preservatives were dispersed in the wet sorbitol solution, and then poured into purified water, followed by primary mixing in a mixer, and then a vegetable abrasive and a medicinal agent were added and mixed. Finally, a foaming agent was added sodium lauryl sulfate, stabilizers, flavoring ingredients and mixed under vacuum to prepare a toothpaste composition.

 Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Vegetable Abrasive (Chinese Cabbage Leaf) 1.00 20.00 30.00 60.00 Silica 20.00 30.00 15.00 Calcium dihydrogen phosphate 10.00 40.00 Calcium carbonate 25.00 30.00 baking soda 10.00 20.00 Sorbitol 30.00 30.00 30.00 30.00 30.00 30.00 30.00 Sodium lauryl sulfate 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Saccharin Sodium 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Paraoxybenzoic acid ester 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Carboxymethyl Cellulose Sodium 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Sodium monofluorophosphate 0.76 0.76 0.76 0.76 0.76 0.76 0.76 Sodium fluoride 0.22 0.22 Triclosan 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 With purified water 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0

Experimental Example 1 Tooth Wear Test

The wear test of the toothpaste compositions of Examples 1 to 4 and Comparative Examples 1 to 4 of Table 1 was performed in vitro using human teeth extracted.

1) Experiment Method

It is a measure of the wear of toothpaste by the volume of the sample tooth cut surface worn by a certain number of brushing. During brushing, the maximum bristle pressure of 350 g is placed on the surface of the sample tooth section, followed by 3,000 brushing strokes of 200 rows per minute. The equipment used at this time was manufactured directly by Brushing M / C. Remove the sample tooth piece from the sample tooth piece holding device and measure the worn surface of the sample tooth piece on the recorded paper by measuring the worn surface again with the surface profiler. The surface volume was calculated.

2) Experiment result (Table 2)

Experimental Toothpaste Group Abrasive Base Tooth wear Rating Comparative Example 1 Calcium carbonate 76 River Comparative Example 2 Silica 63 medium Comparative Example 3 Calcium dihydrogen phosphate 45 medium Comparative Example 4 Sodium bicarbonate + silica 20 about Example 1 Vegetable Abrasive + Calcium Carbonate 60 medium Example 2 Vegetable Abrasive + Silica 50 medium Example 3 Vegetable Abrasive + Calcium Dihydrogen Phosphate 35 Chinese medicine Example 4 Vegetable abrasive alone 30 about

As can be seen from Table 2, a comparison between a toothpaste containing calcium carbonate, calcium dihydrogen phosphate, silica, alumina, and the like, and an abrasive containing a vegetable abrasive (cabbage leaf), which is a commercially available abrasive, is used alone or in combination. Approximate degree of wear during application, making it suitable for use as an abrasive in toothpaste. For reference, it is allowed to sell up to a toothpaste having a comparative wear level of 200, which is calculated based on a wear rate of 100 of a standard toothpaste containing 40% of calcium carbonate as an abrasive (in the US and Europe).

Experimental Example 2 Plaque Removal Effect

Clinical experiments on the plaque removal effect using the toothpaste compositions of Examples 1 to 2 and Comparative Examples 1 to 4 of Table 1 were carried out.

1) Experiment Method

① Screening the subject and explain the oral examination.

(2) Each of the subjects and the comparative examples were divided into 30 random subjects, trained in the proper method of brushing the teeth, and after the oral examination, the Quigley-Hein Index modified by Turesky and the Gingival Bleeding Index, Loe-Silness Index).

③ Scale before the experimental group.

④ After the control toothpaste was used for 14 days, oral examination was performed. At this time, the plaque index and the gingival index were initial values.

⑤ Example Toothpaste and Comparative Example Toothpaste was distributed to each subject and tooth brushing was performed 3 times a day 3 times a day in the same manner as usual, oral examination was performed at 1 month, 3 months to score plaque index and gingivitis index.

⑥ The experimental results were compared with the initial values of the experimental group and the scores after 1 month and 3 months of use.

2) Experiment result

(1) plaque index

Experimental Toothpaste Group Initial value 1 month 3 months Example 1 2.99 ± 0.65 2.80 ± 0.44 2.38 ± 0.36 Example 2 3.23 ± 0.54 2.62 ± 0.69 2.46 ± 0.20 Comparative Example 1 3.20 ± 0.59 3.00 ± 0.84 2.86 ± 0.45 Comparative Example 2 3.00 ± 0.96 2.96 ± 0.43 3.26 ± 0.53 Comparative Example 3 3.27 ± 0.68 3.13 ± 0.27 2.98 ± 0.47 Comparative Example 4 3.32 ± 0.52 3.25 ± 0.63 3.21 ± 0.83

The toothpaste composition of Examples 1 to 2 and Comparative Examples 1 to 4 was measured statistically significantly after measuring the plaque index after 3 months of use. As a result of the plaque formation inhibition effect in Examples 1 to 2 and Comparative Examples 1 to 4 Significant effects were found before and after use, and the plaque removal effect was excellent in toothpaste formulated with a certain amount of vegetable abrasive. In particular, as shown in Comparative Examples 1 and 1, the use of a vegetable abrasive and calcium carbonate in combination with the calcium carbonate alone group showed a much better plaque removal effect.

(2) gingival index

Experimental Toothpaste Group Initial value 1 month 3 months Example 1 1.05 ± 0.43 0.83 ± 0.46 0.72 ± 0.44 Example 2 0.99 ± 0.24 0.87 ± 0.15 0.85 ± 0.20 Comparative Example 1 1.26 ± 0.50 1.09 ± 0.26 0.84 ± 0.19 Comparative Example 2 1.14 ± 0.34 1.00 ± 0.29 1.16 ± 0.20 Comparative Example 3 1.20 ± 0.40 1.08 ± 0.15 1.00 ± 0.25 Comparative Example 4 0.94 ± 0.28 0.97 ± 0.35 1.06 ± 0.15

The toothpaste composition of Examples 1 to 2 and Comparative Examples 1 to 4 was measured statistically significantly after measuring the gingival index after 3 months and used in Examples 1 to 2 and Comparative Examples 1 to 4 for the gingivitis relief effect. Significant effects were found before and after use, and gingival inflammation and treatment effect was found to be good in the toothpaste formulated with vegetable abrasive. In particular, as shown in Comparative Example 1 and Example 1, compared to the calcium carbonate alone group, Example 1 toothpaste using a mixture of vegetable abrasive and calcium carbonate was found to have an excellent effect similar to the plaque removal effect even in the gingival inflammation relieving effect (p. <0.05).

The oral hygiene composition containing the vegetable abrasive of the present invention is excellent in preventing tooth decay, preventing periodontal disease, removing bad breath, whitening effect and gum massage effect, and use the existing abrasive even if the mineral mineral contained in the vegetable abrasive acts on the oral cavity for a long time. Higher safety for human body than conventional oral hygiene composition

Claims (5)

A dentifrice composition comprising 1.00% to 60% by weight of the total weight of the composition of a vegetable abrasive comprising cabbage leaves, green tea leaves, lettuce leaves, ginkgo leaves, maple leaves, pine needles and banana peel fibers. The method of claim 1, wherein the vegetable abrasive is prepared by lyophilizing the components including the fiber of the leaves, stems, nut shells of the plant and then pulverized the fibrous powder obtained in the starch solution to prepare a particle size of 0.01㎛ to 20㎛ Toothpaste composition, characterized in that one. delete The toothpaste composition of claim 1, wherein the polishing rate of the vegetable abrasive is 10 to 200. The method according to any one of claims 1, 2, and 4, wherein the vegetable abrasive contains at least one conventional abrasive selected from silica, potassium carbonate, sodium bicarbonate, calcium dihydrogen phosphate, and alumina. Toothpaste Composition.