KR101810037B1 - Toothpaste composition including gardenia fruit extracts - Google Patents

Abstract

The present invention relates to a toothpaste composition containing Gardenia jasminoides which can obtain effects of preventing and treating periodontal diseases, preventing tooth decay, and removing bad breath by pharmacological action of the Gardenia jasminoides, and the present invention uses an extract of the Gardenia jasminoides as a medicinal agent.

Description

Toothpaste composition including gardenia fruit extracts < RTI ID = 0.0 >

The present invention relates to a dentifrice composition containing a gum, and more particularly, to a dentifrice composition containing a gum base which is capable of preventing and treating periodontal disease, preventing tooth decay and removing bad breath by pharmacological action of the gum.

If oral cleaning is not maintained through tooth brushing, a dental plaque is created in the teeth, and the teeth are gradually calcified to create a dental calculus on the tooth surface. Dental Plaque and Dental Calculus proliferate oral bacteria to cause gum disease such as gingivitis and periodontitis, and bad breath.

Therefore, it is important to brush the teeth well before the food is left in the mouth after eating, and the choice of toothpaste is also very important.

On the other hand, fluorine is widely used as the most typical tooth decay preventive ingredient used in toothpaste, but it has been reported that the use of fluoride-containing toothpaste for a long period of time causes side effects that promote inflammation of the gums. Thus, although toothpastes using natural substances having little side effects on the human body are being provided, their effects are negligible.

Korean Patent Registration No. 10-0852881 (2008.08.12.)

The present invention has been proposed in view of the above points, and it is an object of the present invention to provide a dentifrice-containing dentifrice composition which can prevent and treat periodontal diseases, prevent tooth decay, .

According to the present invention, there is provided a dentifrice composition comprising an abrasive, a binder, a wetting agent, a surfactant, a sweetener and a medicinal agent, wherein the abrasive is selected from the group consisting of silicic acid, zeolite, calcium hydrogenphosphate anhydrate, calcium hydrogenphosphate dihydrate, Aluminum hydroxide, magnesium carbonate and zirconium silicate are used to remove plaque in the oral cavity, and the above-mentioned disintegrating agent is selected from gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium alginate, At least one of gum, sodium polyacrylate, gum arabic, guar gum, polyvinyl alcohol and polyvinylpyrrolidone is used so that the powder component and the liquid component are not separated, and the wetting agent is sorbitol, butylene glycol Is used to prevent the toothpaste from hardening by contacting with the air, and the surfactant Anionic surfactants such as N-acyl amino acid salts, N-acyl sulfonic acid salts, alkyl sulfate salts, glycerin fatty acid ester sulfate, or polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, alkylolamides, glycerin fatty acid One or more nonionic surfactants selected from the group consisting of stearic acid, glycerin, maltitol, xylitol, maltitol, xylitol and arabitol, Is used in an amount of 5 to 20 parts by weight of the abrasive powder, 0.5 to 5 parts by weight of the abrasive powder, 0.5 to 5 parts by weight of the abrasive powder, The dentifrice composition may include a sponge composition containing 20 to 50 parts by weight of a wetting agent, 0.5 to 2.5 parts by weight of the surfactant, 0.05 to 0.5 parts by weight of the sweetener, and 2 to 10 parts by weight of the gardenia extract.
According to the present invention, 3 to 7 parts by weight of mung bean flour may be further included.
In addition, according to the present invention, germinated mung bean flour is prepared by immersing the mung bean in water and germinating for 5 days, followed by drying and pulverizing. The germinated mung bean flour may be contained in an amount of 3 to 7 parts by weight.

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The present invention having the above-described composition is excellent in the prevention and treatment of periodontal diseases, prevention of tooth decay, and removal of bad breath, so that it is possible to hygienically manage oral hygiene with only brushing teeth. Moreover, .

Hereinafter, the present invention will be described more specifically.
The dentifrice composition of the present invention comprises an abrasive, a wetting agent, a binder, a surfactant, a sweetener, a pH adjusting agent, and a medicinal agent.

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Gardenia jasminoides Ellis is a dried genuine fruit of gardenia, the main component is genipin, and the yellow component of the fruit is crocin. Such a gardenia is also used as a medicinal herb. Its antioxidant, antibacterial and anti-inflammatory effects are known by its pharmacological effect and also has a hemostatic function.

The gardenia extract is the solvent extraction or hot water export of the gardenia. Preferably, a gardenia extract which is exported with hot water is used. The gardenia extract is prepared by adding 2 to 3 ginger powder per 1 liter of purified water and heating the mixture at 50 to 60 ° C for 3 to 5 hours.

In the present invention, 2 to 10 parts by weight of such a gardenia extract solution is included. If the tooth extract is contained in an amount of less than 2 parts by weight, it is difficult to expect the effect of the extract from the gardenia extract. If the tooth extract is contained in an amount exceeding 10 parts by weight, the gardenia flavor is excessively strong, If you make toothpaste on top of the toothpaste, it can also cause problems with toothpaste formulation.

As the gardenia extract is used in the present invention, antimicrobial and anti-inflammatory functions of the tooth extract can prevent and treat periodontal diseases, prevent tooth decay, and remove bad breath. In addition, the dentifrice pigment has a pale yellow color, which is different from the conventional dentifrice composition.

On the other hand, the abrasive, the binder, the wetting agent, the surfactant, the sweetener, and the pH adjuster are conventionally used as raw materials for the dentifrice composition, and they are compounded in a conventional mixing range in the preparation of the dentifrice composition.

A brief description of these raw materials is as follows.

The abrasive is a substance which functions to remove plaque in the oral cavity, and is a silica-based abrasive such as silicic acid, crystalline silica, amorphous silica, silica gel and aluminosilicate, zeolite, calcium hydrogenphosphate anhydride, calcium hydrogen phosphate dihydrate, One or more of calcium fluoride, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate and zirconium silicate is used. In view of foaming, it is preferable to use a silica-based abrasive. The abrasive is usually included in the dentifrice composition in an amount of 5 to 20 parts by weight.

The viscous solution is prepared so as not to separate the powder component and the liquid component from each other, and it is preferable to use a gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, Polyvinyl alcohol, and polyvinyl pyrrolidone. The dentifrice is usually contained in the dentifrice composition in an amount of 0.5 to 5 parts by weight.

Examples of the wetting agent include one or two or more of sorbitol, propylene glycol, butylene glycol, and glycerin, which prevent toothpaste from hardening by contact with air in order to suppress moisture and water evaporation. The wetting agent is included in the dentifrice composition in an amount of 20 to 50 parts by weight.

Examples of the surfactant include anionic surfactants such as N-acyl amino acid salts, N-acyl sulfonic acid salts, alkyl sulfate salts and sulfate of glycerin fatty acid ester, polyoxyethylene alkyl ethers, polyoxyethylene- Glycerin fatty acid esters and the like are used alone or in combination of two or more. The surfactant is usually contained in an amount of 0.5 to 2.5 parts by weight based on the dentifrice composition.

As the sweetening agent, saccharin sodium, stevioside, glycyrrhizin, tomatin, paratinose, maltitol, xylitol, arabitol and the like are used. The sweetener is usually included in the dentifrice composition in an amount of 0.05 to 0.5 parts by weight.

As the pH adjusting agent, acetic acid, phosphoric acid, sodium phosphate, citric acid, maleic acid, succinic acid, glutamic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate and sodium phosphate are used. A suitable pH of the dentifrice composition is from 5 to 8.

Examples 1 to 3

Ingredients were compounded in a blending ratio (parts by weight) as shown in Table 1 to prepare a paste dentifrice composition.

Example 1
Example 2
Example 3
Comparative Example 1
Comparative Example 2

Gardenia extract

2
5
10
One
11
Silica gel
15
15
15
15
15

gelatin

2
3
5
2
5
Sorbitol
20
20
20
20
20

Alkyl sulphate
2.5

2.5
2.5
2.5
2.5
Arabitol

0.5
0.5
0.5
0.5
0.5
Citric acid

0.5
0.5
0.5
0.5
0.5

<Efficacy and sensory evaluation>

50 subjects with periodontal disease, periodontal disease, gingival bleeding, diarrhea, and gingival diseases were randomly selected and divided into 5 groups. Fifty testees were allowed to use the dentifrice compositions prepared in Examples 1 to 3 and Comparative Examples 1 and 2 three times a day for four weeks. At this time, blood tests were forbidden for oral care, which could affect antibiotic dosing and testing during the experiment.

 Then, gum disease treatment effect, bad breath removal effect and sensory evaluation were carried out by the following methods, and the evaluation results are shown in Table 2.

1. Measuring gum disease treatment effect

 The treatment satisfaction of gum disease such as periodontitis, gum bleeding, and ishim rim was assessed on a scale of 5 points, and the gingival disease treatment effect was measured by the average value.

 Evaluation criteria: 1 point - Very dissatisfied, 2 points - Dissatisfied, 3 points - Average, 4 points - Satisfaction,

            5 points - Very satisfied

 2. Measures to remove bad breath

The degree of bad breath was measured with a Halimeter for each test subject before (before the experiment) and after 4 weeks (after the experiment) the dental composition prepared in Examples 1 to 3 and Comparative Examples 1 and 2 The odor removal effect was measured by the average value of the values.

3. Sensory Evaluation

After using the dentifrice compositions prepared in Examples 1 to 3 and Comparative Examples 1 and 2 for 4 weeks, evaluation was made based on a 5-point scale with respect to evaluation of freshness, freshness, color and flavor, and overall acceptability, The effect of gum disease treatment was measured.

 Evaluation criteria: 1 point - Very dissatisfied, 2 points - Dissatisfied, 3 points - Average, 4 points - Satisfaction,

            5 points - Very satisfied

division
Item
Example 1
Example 2
Example 3
Comparative Example 1
Comparative Example 2




Gum disease

Periodontitis
3.7
4.1
4.6
3.2
4.7

Bleeding
4.0
4.3
4.5
3.0
4.6

Ishim Rim
3.6
3.9
4.1
3.0
4.1



Bad breath

Immediately after the experiment
221.3
216.6
231.1
210.7
230.5

After 4 weeks
105.3
86.5
100
175.2
95.7






Sensory evaluation



Feeling of exhilaration
3.5
4.0
4.3
3.4
4.2

Recuperation
4.0
4.0
4.4
3.7
4.0

color
3.9
4.3
4.7
3.1
3.0

incense
4.0
4.0
4.1
4.0
3.0

Overall likelihood
4.0
4.3
4.5
3.3
3.4

The above table shows that the more the amount of the gardenia extract is contained, the more the gum disease and posterior removal effect is improved. However, when the gardenia extract is more than 10 parts by weight, the evaluation of color and fragrance is not good. This is because the color of the toothpaste is excessively dark yellow due to the gardenia extract, and the juice of the gardenia is strong.

In the cases of Examples 1 to 3, the degree of satisfaction with the treatment of gum disease and the degree of bad breath removal was evaluated to be fairly satisfactory. Accordingly, the dentifrice composition according to the present invention has excellent effects such as treatment of gum disease and removal of bad breath.

Examples 4 to 5

In Examples 4 and 5, mung bean flour and germinated mung bean flour are further included.

Mung bean (Phaseolus radiatus L) has flavor and cold properties. Its main ingredient is carbohydrate, but it is one of the foods that it is precious since it is high in nutrition because it has many proteins. Mung bean has detoxification and antipyretic action, and anti-inflammatory action.

In particular, germinated mung bean has more anti-inflammatory activity than general mung bean because it contains more anti-inflammatory substance than general mung bean. If germinated mung bean is used, the mung bean is immersed in water and germinated for 5 days, then dried and pulverized to make germinated mung bean flour.

When the mung bean is used together with the gardenia extract and the pharmacological action of the mung bean is similar to that of the garden mucosa, the pharmacological actions of the mung bean are synergistic with each other and have a remarkably good effect on oral hygiene including gum disease treatment as described later.

The raw materials were compounded in a blending ratio (parts by weight) as shown in Table 3 to prepare a paste dentifrice composition.

Example 4
Example 5

Gardenia extract

10
10
Mung bean powder
5
-

Germinated mung bean powder
-
5

Silica gel
20

20
gelatin

3
3
Sorbitol
20
20

Alkyl sulphate
2.5

2.5
Arabitol

0.2
0.2
Citric acid

0.5
0.5

<Efficacy and sensory evaluation>

Twenty subjects who had gum disease and bad breath such as periodontal disease, gum bleeding, isthmus and the like were selected and divided into two groups of 10 persons. The dentifrice compositions prepared in Examples 4 and 5 were used three times a day, The results are shown in Table 4 together with the results of Example 3. The results are shown in Table 4.

division
Item
Example 4
Example 5
Example 3




Gum disease


Periodontitis

4.7
4.8
4.6
Bleeding gums

4.6
4.7
4.5
This

4.1
4.2
4.1


Bad breath

Immediately after the experiment

219.3
229.7

231.1
After 4 weeks

88
99.6
100






Sensory evaluation




Feeling of exhilaration

4.5
4.6
4.3
Recuperation

4.5
4.7
4.4
color
4.5
4.5
4.7

incense
4.0
4.0
4.1

Overall likelihood
4.6
4.7
4.5

As shown in the above table, Examples 4 and 5 were evaluated more favorably than those of Example 3 in which the same amount of the extract of the gardenia was used in various evaluations including gum disease. This is because, in the pharmacological action of the gardenia extract, And the pharmacokinetics of the drug. In particular, Example 5 using germinated mung bean flour was better evaluated in Example 4.

In this embodiment, 5 parts by weight of mung bean flour or germinated mung bean flour is included, but 3 to 7 parts by weight of mung bean or germinated mung bean flour is included. When the content of mung bean flour and germinated mung bean flour is less than 3 parts by weight, it is difficult to expect the effect of them. When the content of mung bean flour or germinated mung bean flour exceeds 7 parts by weight, the content of mung bean flour or germinated mung bean flour The amount of the dentifrice composition is relatively undesirable because the overall functional balance of the dentifrice composition may deteriorate. In addition, since the mung bean flour or the germinated mung bean flour has a sweet taste, the sweeteners are slightly less in the present embodiments than the above embodiments.

Claims (4)

delete A dentifrice composition comprising an abrasive, a binder, a wetting agent, a surfactant, a sweetener and a medicinal agent,
The abrasive may be at least one selected from the group consisting of silicic acid, zeolite, calcium hydrogenphosphate anhydrate, calcium hydrogenphosphate dihydrate, calcium pyrophosphate, aluminum hydroxide, magnesium carbonate and zirconium silicate to remove plaque in the oral cavity,
The viscous solution may contain one or two of gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum, polyvinyl alcohol and polyvinylpyrrolidone Or more is used so that the powder component and the liquid component are not separated,
The wetting agent may be one or two or more selected from the group consisting of sorbitol and butylene glycol to prevent the toothpaste from hardening by contact with air,
The surfactant may be at least one selected from the group consisting of N-acyl amino acid salts, N-acyl sulfonic acid salts, alkyl sulfate salts, glycerin fatty acid ester sulfate anionic surfactants and polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, , A nonionic surfactant of glycerin fatty acid ester,
The sweetener may be at least one selected from the group consisting of stevioside, glycyrrhizin, tomatine, paratinose, maltitol, xylitol, and arabitol,
The pharmacological agent is prepared by adding 2 ~ 3 ginger powder per 1 liter of purified water and heating at 50 ~ 60 ° C for 3 ~ 5 hours,
The wetting agent may be used in an amount of 20 to 50 parts by weight, the surfactant may be used in an amount of 0.5 to 2.5 parts by weight, the sweetener may be used in an amount of 0.05 to 0.5 parts by weight, Is contained in an amount of 2 to 10 parts by weight per 100 parts by weight of the dentifrice composition.
3. The method of claim 2,
Wherein the composition further comprises 3 to 7 parts by weight of mung bean flour.
3. The method of claim 2,
Further comprising germinated mung bean flour prepared by dipping mung bean in water and germinating for 5 days, followed by drying and pulverizing,
Wherein the germinated mung bean flour is contained in an amount of 3 to 7 parts by weight.