KR20140023081A

KR20140023081A - Toothpaste composition containing stone cell and toothpaste prepared therefrom

Info

Publication number: KR20140023081A
Application number: KR1020120089703A
Authority: KR
Inventors: 정주찬
Original assignee: 정주찬
Priority date: 2012-08-16
Filing date: 2012-08-16
Publication date: 2014-02-26

Abstract

The present invention relates to a stone cell-containing toothpaste composition, 1) stone cells; 2) xylitol as a caries prevention component; 3) allantoin, bamboo salt or mixtures thereof as a periodontal disease prevention component; 4) glycerin as a humectant component; 5) xanthan gum as binder component; 6) essential oils as flavor components; And 7) the stone cell-containing toothpaste composition of the present invention comprises water, instead of the conventional abrasives such as silicon dioxide, precipitated calcium carbonate, tricalcium phosphate, potassium nitrate, and the like. By containing it, the removal efficiency of plaque is high, without damaging a tooth, and it does not adversely affect periodontal disease, and it can be usefully used for manufacturing the toothpaste which can be used safely even in a patient suffering from periodontal disease.

Description

Toothpaste composition containing stone cells and toothpaste prepared therefrom {TOOTHPASTE COMPOSITION CONTAINING STONE CELL AND TOOTHPASTE PREPARED THEREFROM}

The present invention relates to a toothpaste composition containing stone cells and toothpaste prepared therefrom. Specifically, by containing stone cells instead of chemical abrasives included in the existing toothpaste, damage to teeth without worsening periodontal disease It relates to a dentifrice composition and toothpaste prepared therefrom which can effectively remove plaque while minimizing.

Plaque is a plaque formed on the surface of the tooth, often called plaque, and the plaque itself is not visible to the naked eye. Plaque is formed in the form of a very thin and transparent membrane consisting of bacteria, their metabolites, and human saliva. When these plaques are formed, they grow inside the bacteria and use the sugars we supply as we eat foods They grow exponentially and their quantity increases.

Therefore, plaque will cover all sides of the tooth within minutes after ingesting food, and the bacteria in the plaque secrete acidic substances to corrode the lime components of the tooth, causing tooth decay, as well as the toxins produced when they erode the gums. It also acts as a cause of inflammation. Therefore, the reason for brushing teeth using toothpaste is to effectively remove this plaque.

When examining these plaques, experts often examine the Oral Plaque Index (PI) using the O'Leary chart, a four-piece dental plaque chart, which explains in more detail the Ollie chart. Is as follows.

The tooth is divided into six parts as originally shown in FIGS. 1 and 2. The outer and inner surfaces of the teeth are the one-third part of the distal side (green part in Figs. 1 and 2), the central one-third part (white part in Figs. 1 and 2 in yellow), and each part may be divided by 1/3 and displayed on both sides and the center. However, since the Oliary chart is divided into quadrants only, as shown in FIG. 3, the third and third centrifugal side portions of the outer and inner sides of the tooth may be displayed as the same region.

On the other hand, tartar means that the plaque is not removed, combined with the lime material in saliva, and the mineral is deposited and hardened over time. According to the location, attachment form, and coloration of the tartar, the gingivative tartar or the gingival tartar, the hard mass It can be classified into mold tartar, shelf tartar or veneer tartar, or externally colored tartar or internally colored tartar. Hard surface tartar itself may irritate the gums and irritate the gums, but more importantly, these tartars become a breeding ground for bacteria. In other words, the place where the tartar is the place where the plaque is, and the site is a state where the inflammation of the gum can be started at any time, once the plaque is formed, plaque is easily attached on the tartar to cause the progression of the gingivitis inflammation.

To prevent the formation of tartar and effectively remove plaque, toothpaste is often used to brush teeth.

However, in general, toothpaste uses chemical abrasives such as silicon dioxide, precipitated calcium carbonate, tricalcium phosphate, potassium nitrate, etc., which remove plaque, tartar, and the like attached to teeth and impart an original luster to the tooth surface. Depending on the type of toothpaste, toothpaste containing a strong abrasive such as silicon dioxide or a weaker abrasive, such as tricalcium phosphate or potassium nitrate, is commercially available for people with symptomatic ache. There is a problem that accelerates tooth damage, worsen periodontal disease, and the general public is difficult to choose the toothpaste that is suitable for them because they do not know the strength of the abrasive.

An object of the present invention is to exhibit an excellent plaque removal effect without using a chemical abrasive, which has been included in the existing toothpaste to remove plaque stuck to the tooth surface, thereby minimizing tooth damage without affecting periodontal disease. It is to provide a toothpaste composition that can be usefully used in the manufacture of toothpaste that can effectively remove plaque.

In the present invention to achieve the above object, 1) stone cells; 2) xylitol as a caries prevention component; 3) allantoin, bamboo salt or mixtures thereof as a periodontal disease prevention component; 4) glycerin as a humectant component; 5) xanthan gum as binder component; 6) essential oils as flavor components; And 7) water, which comprises a stone cell-containing toothpaste composition.

In addition, the present invention provides a toothpaste prepared by using the lipocyte-containing toothpaste composition.

The stone cell-containing toothpaste composition of the present invention does not include chemical abrasives such as silicon dioxide, tricalcium phosphate, potassium nitrate, and the like, and thus can provide a very good plaque removal effect with little tooth damage while being safe for periodontal disease.

1 and 2 are schematic diagrams showing the maxillary and mandibular anterior teeth of a tooth, respectively.
Fig. 3 is a schematic diagram showing an Oliary chart colored with a part corresponding to the part colored in Figs. 1 and 2;
4 and 5 are photographs of stone cells isolated from lumps of lumps and lumps, respectively.
6 and 7 are micrographs (100 ×) of pears and apples, respectively.
8 is a schematic view showing a rotation method.
Figure 9 is a graph showing the PI before and after pear intake in Experimental Example 1.
Figure 10 is a graph showing the PI before and after apple intake in Experimental Example 1.
11 is a graph showing the average PI reduction before and after intake of pears and apples in Experimental Example 1.
12 is a graph showing PI before and after chewing gum in Experimental Example 2. FIG.
FIG. 13 is a graph showing average PI reduction after pear ingestion and after chewing gum.
FIG. 14 is an Oli chart showing the PI index before and after the use of a scavenger-free toothpaste and a scavenger-containing toothpaste. FIG.

The stone cell-containing toothpaste composition according to the present invention, instead of the chemical abrasive contained in the existing toothpaste, containing a stone cell having the effect of effectively removing the plaque formed on the tooth surface without damaging the tooth without adversely affecting periodontal disease It features.

Specifically, the stone cell-containing toothpaste composition according to the present invention comprises 1) stone cells; 2) xylitol as a caries prevention component; 3) allantoin, bamboo salt or mixtures thereof as a periodontal disease prevention component; 4) glycerin as humectant; 5) xanthan gum as binder; 6) essential oils as flavoring agents; And 7) water.

Hereinafter, each component is demonstrated.

1) stone cells

In the present invention, stone cells refer to cells whose cross-sections are hardly branched into regular polygons, the cell walls are markedly thickened, and the walls exhibit a clear layer structure. Stone cells can be seen, for example, in the flesh of a pear, and yellow grains visible to the naked eye in a pear are lumps of stone cells made up of stone cells gathered as shown in FIG. 4. These stone cells are thickened to protect the seeds, which are called thick wall cells (one of the components of the rear wall tissue that serve to strengthen and support the plant). These stone cells are believed to be made to protect the seeds as an evolutionary strategy for the embryo to survive, especially in the middle of the seeds that are not consumed by many people.

Stone cells are known to be present in the membranous skin (pulp) of the pear (see Fig. 6), and not only the pear but also the peony and dahlia tubers are scattered in groups of several, and endothelial such as plum and peach ( Seed bark) is almost entirely composed of stone cells.

In the present invention, the masonry cells may be included in an amount in the range of 47 to 53% by weight based on the total weight of the toothpaste composition.

Stone cells in the toothpaste composition according to the present invention is excellent in removing plaque without damaging the teeth or affecting the periodontal disease, when used in place of the chemical abrasive included in the existing toothpaste, even patients suffering from periodontal disease You can get toothpaste that can be used with confidence.

2) Xylitol as a caries prevention ingredient

Xylitol is a natural sweetener mainly found in plants such as birch, oak, corn, cherry, vegetables, and fruits. It is a sweetening ingredient that has a sweetness similar to sugar and low in calories. Also used. Hydrolysis of the birch, almond shells, oat shells, homes, and sugar cane converts the polysaccharide xylan to xylose, which can be obtained by adding hydrogen to xylose.

Xylitol has a unique pentose structure that can't degrade caries, so it has a function to reduce tooth decay. Specifically, for example, mutans bacteria, which are representative tooth decay bacteria, mistake xylitol, which is similar to sugar, to be eaten as sugar. Xylitol is not digested by caries, which does not produce acid, which is a cause of tooth damage. In the process of continuing to consume xylitol, all of the energy is weakened and activity is weakened, which can suppress the growth of caries, reduce the formation of plaque, a bacterial membrane on the surface of the tooth, and prevent the production of acids by reducing the formation of cavities.

Xylitol as a caries prevention component may be included in an amount ranging from 8 to 12% by weight, based on the total weight of the toothpaste composition of the present invention.

3) Allantoin and Bamboo Salt as Periodontal Disease Prevention Components

In the dentifrice composition of the present invention, allantoin, bamboo salt or a mixture thereof may be used as a component for preventing periodontal disease such as gingivitis and periodontitis.

Allantoin is a natural substance that can be obtained by extracting from oak, comfrey root, sugar beet, wheat germ, etc. Bamboo salt removes the natural salt toxicity by putting natural sun salt into bamboo barrel and baking it at 800 ℃ or higher for 8 times and melting above 1500 ℃. Can be obtained, and they have an excellent effect in preventing periodontal disease.

In the present invention, periodontal disease prevention components such as allantoin, bamboo salt and the like may be included in an amount ranging from 1 to 3% by weight based on the total weight of the dentifrice composition.

4) Glycerin as Wetting Agent

Glycerin, which is used as a humectant component in the toothpaste composition of the present invention, serves to prevent the toothpaste from solidifying even when the toothpaste is in contact with air by making the toothpaste have an appropriate humidity, and it is 19 to 21 based on the total weight of the toothpaste composition of the present invention. It may be included in amounts ranging from% by weight.

5) xanthan gum as binder

Xanthan gum used as a binder component in the toothpaste composition of the present invention serves to uniformly mix the ingredients of the toothpaste and to maintain a stable form of the toothpaste, 1 to 3% by weight based on the total weight of the toothpaste composition of the present invention It can be included in an amount in the range.

6) essential oils as flavoring agents

The essential oil used as a flavoring ingredient in the toothpaste composition of the present invention refers to an essential oil (essential oil) extracted from the leaves, stems, shells, petals, roots, etc. of aromatic stone plants grown in nature or grown by organic farming methods. By adding aroma to the toothpaste to clean and refresh the mouth and may be included in an amount ranging from 0.01 to 0.03% by weight based on the total weight of the toothpaste composition of the present invention.

7) water

For example, water may be purified water purified by reverse osmosis, fine filter filtration, or the like, and may be added in an amount such that the total of the components 1) to 6) and water are 100% by weight.

In addition, potassium nitrate, tricalcium phosphate (attenuate), sodium lauryl sulfate (foaming agent), carboxymethylcellulose (binder), and the like, which are generally used in toothpaste compositions, may be used within the scope not contrary to the object of the present invention. have.

Stone cell-containing toothpaste containing the toothpaste composition of the present invention may be prepared according to a conventional toothpaste manufacturing process, for example, dissolving xanthan gum in water (for example, purified water) at 40 to 50 ℃, 40 to 50 ℃ While maintaining the temperature in the range of the wetting agent such as glycerin, caries prevention component such as xylitol, periodontal disease prevention component such as allantoin, bamboo salt, dissolved by weighing and dissolving it, continued stirring and mixing, cooling and adding essential oil It can be obtained by adding stone cells and mixing by stirring.

In addition, the stone cell-containing toothpaste composition according to the present invention, instead of the chemical abrasive contained in the existing toothpaste composition, by containing the stone cells with excellent removal effect such as plaque without tooth damage without adversely affecting periodontal disease, periodontal Disease patients and the like can also be usefully used to prepare toothpaste that can be used with confidence.

Hereinafter, the present invention will be described in more detail based on the following examples. However, the following examples are intended to illustrate the present invention, but the scope of the present invention is not limited thereto.

Example 1 Isolation of Stone Cells

250 g of pears were added to 500 g of 50% (w / w) aqueous methanol solution, pulverized with a homogenizer, and the supernatant obtained by centrifugation at 12,000 rpm for 10 minutes at 4 ° C. was filtered through a 0.45 μm filter. g of stone cells were obtained.

Example 2: Preparation of Stone Cell-Containing Toothpaste

0.2 g of xanthan gum (Xanthan Gum, Natural Love) was dissolved in purified water (2 g) at about 50 ° C, and glycerin (Natural Glycerin (trade name)) was maintained in another container at a temperature of about 50 ° C. , Seoul F & C) 2 g, xylitol (Xylitol Crystal (trade name), 1 g of powdered nara), 0.2 g of allantoin (powdered nara) and 0.2 g of bamboo salt (hazelnut) were added and dissolved, and the contents of the two containers were stirred with a stirrer. Mixed well and cooled. Stone cells of the present invention by adding 0.001 g (1 drop) of essential oil (Rich Aroma (trade name), Herbage Co., Ltd.) to 5 g of the granulocytes obtained in Example 1 Toothpaste was obtained.

Example 3: Preparation of Stone Cell-Free Toothpaste

In Example 2, the same procedure as in Example 2 was performed except that no masonry cells were added, thereby obtaining a dentifrice-free toothpaste.

end. Purpose of experiment

To see if eating fruit with stone cells can help keep your teeth clean, try eating fruit that does not contain stone cells and fruit that contains stone cells. The effect of plaque removal was quantified to investigate the effect of plaque removal. In addition, the following experiments were conducted to compare the degree of plaque removal of other materials, such as gum, and stone cell-containing fruits, and to investigate the degree of plaque removal of stone cell-containing toothpastes and stone cell-free toothpastes.

I. Experimental Method

1) Study subject

The subjects of this study were 55 males aged 17-19 with relatively good oral condition. Of the 55 people, 25 participated in the comparison of plaque removal effect of fruits without apple cells (apples) and fruits with pear cells (pears), and 30 participated in the comparison of plaque removal effects of fruits with gum and stone cells. Each subject was trained and familiarized with the rotation method described below as a brushing method.

Deformation rotation method is one of the most commonly used methods recommended by the American Dental Association in 1931. It is a good method of removing plaque and food residues, a good massage effect, and a relatively good practice. Specifically, as shown in FIG. 8, the side flanked by the side of the bristle toward the tooth root direction, pushed to the attached gingival and pressed by the gingival rotation, applying force to the inner ear holding the toothbrush from the gum to the occlusal surface This is a way to take a swipe gesture while spinning.

2) control group and experimental group of each experiment

(1) Control: Dye the tooth with a plaque staining agent and record the amount of plaque present in the tooth first.

(2) Experimental Group A: After staining plaque, take pears (45-50g) and record the remaining plaque secondary.

(3) Experiment group B: After staining the plaque, ingest apples (45-50g) and record the amount of remaining plaque second.

(2) Experimental group: After staining the plaque, chewing gum (Xylitol (trade name), (Lotte Confectionery)) for 5 minutes and recording the amount of remaining plaque secondary.

(2) Experimental Group A: After staining the plaque, rub each face of the tooth five times with the scavenger-containing toothpaste obtained in Example 2.

(3) Experimental Group B: After staining the plaque, rub each face of the tooth five times with the scavenger-free toothpaste obtained in Example 3.

3) Experiment Method

In all experiments, the subjects were asked to eat breakfast and brush their teeth on the day of the experiment in order to create as similar oral conditions as possible. Dye solution prepared by dropping 5-6 drops of plaque dye (butler) in a paper cup and diluting it in 10 times the volume of water in order to check the Plaque Index (PI). g was allowed to gargle and spit for 10 seconds. In addition, during the experiment, all food intakes that may affect fluctuations in residual plaque were limited. For the PI test chart, the PI index is recorded on an oliary chart commonly used for plaque examination, and the plaque persistence rate is converted into% to investigate the degree of plaque reduction. Used.

a. Experimental Example 1

Pear (experimental group A) was prepared as fruit containing stone cells, and apple (experimental group B) was prepared as fruit without stone cells. And Experimental Example 1 was carried out as follows.

(1) Experiment Group A

① After staining plaque, first check the PI before ingesting fruit.

② 1/12 pieces (45-50g) of the belly evenly eaten throughout the teeth.

③ Check the remaining PI after ingestion.

④ Compare the percent reduction in PI before and after ingesting pears.

(2) Experiment Group B

① After staining plaque, first check the PI before ingesting fruit.

② Eat 1/12 pieces (45-50g) of apples evenly throughout your teeth.

③ Check the remaining PI after eating apples.

④ Compare the decrease in PI (%) before and after eating apples.

b. Experimental Example 2

Chewing gum was prepared to investigate the reduction rate of plaque through chewing gum known to have some degree of removal effect of plaque, and proceeded to Experimental Example 2 as follows.

(1) experimental group

① After staining plaque, the PI before chewing gum is first examined.

② chew 2g of gum evenly throughout the teeth 5 minutes.

③ Check the remaining PI after chewing gum.

④ Compare the decrease in PI (%) before and after chewing gum.

c. Experimental Example 3

After the preparation of toothpaste containing stone cells, experiments were conducted to find out whether or not stone cells can substitute for the role of chemical abrasives of existing toothpastes.

(1) Experiment Group A

① After the plaque staining, check the PI before brushing your teeth.

② Toothpaste containing tooth cells, each side of the teeth by using the rotation method rub five times.

③ Toothpaste contains toothpaste, rub each side of the tooth five times using the rotation method, and examine the remaining PI.

(In order to fix the effect of brushing on the plaque removal effect, the brushing was limited to 5 times cleaning each side of the tooth, and the brushing method was a rotating method.)

(2) Experiment Group B

① After the plaque staining, check the PI before brushing your teeth.

② Toothpaste without tooth cells, each side of the teeth by using the rotation method rub five times.

③ Toothpaste without tooth cells, rub each side of the tooth five times using the rotation method, and examine the residual PI.

4) Data Analysis

The collected data were analyzed using the computer statistics program SPSS 12.0 and Microsoft Excel after coding in SPSS7, and the significance level used for the significance test was 0.05.

5) Experiment result

The results of the investigation of the remaining amount of plaque before and after the intake of pears in 25 subjects are shown in FIG. 9, and the results of the investigation of the remaining amount of plaques before and after ingestion of apples in 25 subjects are shown in FIG. 10. As a result, it can be seen that after the ingestion of pears containing stone cells, the average plaque reduction rate was 31.91%, while that of the apples containing no stone cells showed a low plaque reduction rate of 6.40% on average (see FIG. 11). .

Thirty patients examined the amount of residual gingiva before and after chewing gum, and the results were shown in FIG. 12. As a result, the rate of plaque reduction was about 6.28%, similar to the case of ingesting apples that did not contain stone cells. As shown in Fig. 13, it was found that the reduction of plaque was significantly lower compared to the case of ingesting pears containing stone cells (31.91% reduction of plaque).

The PI index was measured before and after brushing the teeth with the scavenger-containing toothpaste and the sciatic-free toothpaste (see FIG. 14). Fell to 22.32%. However, in experimental group B, which had been treated with toothpaste without cells, the PI index fell from 100% before brushing to 69.64% after brushing. In other words, after brushing teeth with toothpaste-containing toothpaste, the reduction of plaque was high as 71.43%, while the toothpaste reduction with toothpaste-free toothpaste was 30.36%.

From Experimental Examples 1 to 3, when the fruit is ingested, the effect of reducing plaque is shown to some extent regardless of whether or not the stone cells are contained, but the fruit does not contain the stone cells when the fruit (eg, pear) containing the stone cells is ingested. It's about 5 times (4.99 times) more effective than eating apples (e.g. apples), and people generally think that gums are more effective at removing plaque than fruits, but when chewing gum, stone cells It has a similar effect to low plaque removal as ingesting fruit that does not contain P. oleracea, and the intake of fruits containing stone cells (e.g., pears) is about 5 times (5.08 times) more plaque reduction effect than after chewing gum. It can be seen that high. In addition, when brushing teeth using toothpaste containing stone cells, it can be seen that the effect of removing plaque is much better than brushing teeth using toothpaste not containing stone cells.

Claims

1) stone cells; 2) xylitol as a caries prevention component; 3) allantoin, bamboo salt or mixtures thereof as a periodontal disease prevention component; 4) glycerin as humectant; 5) xanthan gum as binder; 6) essential oils as flavoring agents; And 7) water, a scavenger-containing toothpaste composition.

According to claim 1, 47 to 53% by weight stone cells, 8 to 12% by weight caries prevention component, 1 to 3% by weight periodontal disease prevention component, 19 to 21% by weight wetting agent, 1 to 3% by weight binder, 0.01% flavoring agent To 0.03% by weight and 17 to 21% by weight of water.

Toothpaste prepared using the scavenger-containing toothpaste composition according to claim 1.