KR100513117B1 - Toy for protecting an oral cavity and a teeth of a pet animal - Google Patents
Toy for protecting an oral cavity and a teeth of a pet animal Download PDFInfo
- Publication number
- KR100513117B1 KR100513117B1 KR10-2003-0027292A KR20030027292A KR100513117B1 KR 100513117 B1 KR100513117 B1 KR 100513117B1 KR 20030027292 A KR20030027292 A KR 20030027292A KR 100513117 B1 KR100513117 B1 KR 100513117B1
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- vitamin
- parts
- teeth
- composition
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract description 31
- 210000000214 mouth Anatomy 0.000 title description 20
- 239000000203 mixture Substances 0.000 claims abstract description 51
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000126 substance Substances 0.000 claims abstract description 21
- 229920001661 Chitosan Polymers 0.000 claims abstract description 17
- 238000011049 filling Methods 0.000 claims abstract description 16
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 14
- 150000001413 amino acids Chemical class 0.000 claims abstract description 14
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920000742 Cotton Polymers 0.000 claims abstract description 12
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 11
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 11
- 102000008186 Collagen Human genes 0.000 claims abstract description 10
- 108010035532 Collagen Proteins 0.000 claims abstract description 10
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229920001436 collagen Polymers 0.000 claims abstract description 10
- 229960002477 riboflavin Drugs 0.000 claims abstract description 10
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 10
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 10
- 229930003471 Vitamin B2 Natural products 0.000 claims abstract description 9
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 9
- 235000019164 vitamin B2 Nutrition 0.000 claims abstract description 9
- 239000011716 vitamin B2 Substances 0.000 claims abstract description 9
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims abstract description 9
- 235000005282 vitamin D3 Nutrition 0.000 claims abstract description 9
- 239000011647 vitamin D3 Substances 0.000 claims abstract description 9
- 229940021056 vitamin d3 Drugs 0.000 claims abstract description 9
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 7
- 229960000458 allantoin Drugs 0.000 claims abstract description 7
- 239000004227 calcium gluconate Substances 0.000 claims abstract description 7
- 229960004494 calcium gluconate Drugs 0.000 claims abstract description 7
- 235000013927 calcium gluconate Nutrition 0.000 claims abstract description 7
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims abstract description 7
- 239000011148 porous material Substances 0.000 claims abstract description 6
- 239000012209 synthetic fiber Substances 0.000 claims abstract description 6
- 229920002994 synthetic fiber Polymers 0.000 claims abstract description 6
- 229940024606 amino acid Drugs 0.000 claims abstract description 5
- 229960005188 collagen Drugs 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 230000000737 periodic effect Effects 0.000 claims 1
- 230000003749 cleanliness Effects 0.000 abstract description 4
- 230000036541 health Effects 0.000 abstract description 2
- 210000000515 tooth Anatomy 0.000 description 48
- 208000002925 dental caries Diseases 0.000 description 19
- 238000012360 testing method Methods 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 14
- 238000011156 evaluation Methods 0.000 description 14
- 239000002253 acid Substances 0.000 description 13
- 235000001014 amino acid Nutrition 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 229940034610 toothpaste Drugs 0.000 description 11
- 239000000606 toothpaste Substances 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 9
- 244000005700 microbiome Species 0.000 description 9
- 210000002200 mouth mucosa Anatomy 0.000 description 9
- 241000282472 Canis lupus familiaris Species 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 8
- 210000000988 bone and bone Anatomy 0.000 description 8
- 206010006326 Breath odour Diseases 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 6
- 208000007565 gingivitis Diseases 0.000 description 6
- 235000019629 palatability Nutrition 0.000 description 6
- 201000001245 periodontitis Diseases 0.000 description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 241000194019 Streptococcus mutans Species 0.000 description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000003755 preservative agent Substances 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229960005069 calcium Drugs 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 230000001055 chewing effect Effects 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 239000011574 phosphorus Substances 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 230000007505 plaque formation Effects 0.000 description 4
- 239000000811 xylitol Substances 0.000 description 4
- 235000010447 xylitol Nutrition 0.000 description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 4
- 229960002675 xylitol Drugs 0.000 description 4
- 229920002101 Chitin Polymers 0.000 description 3
- 208000002064 Dental Plaque Diseases 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 229920001503 Glucan Polymers 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 239000005515 coenzyme Substances 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 238000010835 comparative analysis Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 235000019162 flavin adenine dinucleotide Nutrition 0.000 description 2
- 239000011714 flavin adenine dinucleotide Substances 0.000 description 2
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 description 2
- 229940013640 flavin mononucleotide Drugs 0.000 description 2
- 239000011768 flavin mononucleotide Substances 0.000 description 2
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 2
- FVTCRASFADXXNN-UHFFFAOYSA-N flavin mononucleotide Natural products OP(=O)(O)OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-UHFFFAOYSA-N 0.000 description 2
- 229940093632 flavin-adenine dinucleotide Drugs 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 239000002858 neurotransmitter agent Substances 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229960003581 pyridoxal Drugs 0.000 description 2
- 235000008164 pyridoxal Nutrition 0.000 description 2
- 239000011674 pyridoxal Substances 0.000 description 2
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 description 2
- NHZMQXZHNVQTQA-UHFFFAOYSA-N pyridoxamine Chemical compound CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 description 2
- 235000019231 riboflavin-5'-phosphate Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 108020005199 Dehydrogenases Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
- 108010055629 Glucosyltransferases Proteins 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 208000000913 Kidney Calculi Diseases 0.000 description 1
- 206010029148 Nephrolithiasis Diseases 0.000 description 1
- 206010029400 Nicotinic acid deficiency Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 240000002299 Symphytum officinale Species 0.000 description 1
- 235000005865 Symphytum officinale Nutrition 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000012883 Tumor Necrosis Factor Ligand Superfamily Member 14 Human genes 0.000 description 1
- 108010065158 Tumor Necrosis Factor Ligand Superfamily Member 14 Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047612 Vitamin B2 deficiency Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 150000001371 alpha-amino acids Chemical class 0.000 description 1
- 235000008206 alpha-amino acids Nutrition 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 201000007590 ariboflavinosis Diseases 0.000 description 1
- 150000007514 bases Chemical class 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 208000019884 chronic gingivitis Diseases 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000020186 condensed milk Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 150000004715 keto acids Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000011021 lapis lazuli Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 235000013310 margarine Nutrition 0.000 description 1
- 239000003264 margarine Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000021062 nutrient metabolism Nutrition 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 208000024335 physical disease Diseases 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000013630 prepared media Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000022558 protein metabolic process Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 description 1
- 125000002050 pyridoxal group Chemical group 0.000 description 1
- 229960001327 pyridoxal phosphate Drugs 0.000 description 1
- 235000008151 pyridoxamine Nutrition 0.000 description 1
- 239000011699 pyridoxamine Substances 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 208000004223 riboflavin deficiency Diseases 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K15/00—Devices for taming animals, e.g. nose-rings or hobbles; Devices for overturning animals in general; Training or exercising equipment; Covering boxes
- A01K15/02—Training or exercising equipment, e.g. mazes or labyrinths for animals ; Electric shock devices ; Toys specially adapted for animals
- A01K15/025—Toys specially adapted for animals
- A01K15/026—Chewable toys, e.g. for dental care of pets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Physical Education & Sports Medicine (AREA)
- Dentistry (AREA)
- Zoology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
본 발명은 애완동물의 구강 및 치아 보호용 놀이기구에 관한 것으로, 좀 더 구체적으로는 내부 충진물과 이를 밀봉시키며 소정의 형상을 갖는 외피로 구성되고, 상기 내부 충진물은 스폰지의 기공 또는 화학솜의 조밀도가 0.02g/㎤내지 0.20g/㎤인 다공성 및 연질인 스폰지 또는 화학솜이며, 상기 외피는 그물망 또는 레이스 뜨기 한 합성섬유로 이루어지며, 상기 내부 충진물에 자이리톨 10 내지 50중량부; 키토산 0.05 내지 20중량부; 비타민 B2, 비타민 B6, 비타민 D3, 알란토인, 글루콘산칼슘, 아미노산 및 콜라겐으로 이루어진 군으로부터 하나 또는 그 이상 선택된 성분 0.001 내지 6중량부; 및 나머지는 물을 포함하며, 700∼4000cps의 점도 및 5.5∼7의 pH를 갖는 액상조성물의 주기적으로 주입이 가능한 애완동물의 구강 및 치아 보호용 놀이기구에 관한 것이다. 상기 조성물은 동물의 치아 및 구강의 청결과 건강을 유지시키며, 식용이 가능하다.The present invention relates to a pet oral and dental care rides, and more specifically, to the inner filling and sealing it and has a predetermined shape, the inner filling is the density of the pores or chemical cotton of the sponge Is 0.02 g / cm 3 to 0.20 g / cm 3 of porous and soft sponge or chemical cotton, wherein the outer shell is made of a mesh or laced synthetic fiber, and 10 to 50 parts by weight of ziritol in the inner filling; Chitosan 0.05 to 20 parts by weight; 0.001 to 6 parts by weight of one or more components selected from the group consisting of vitamin B2, vitamin B6, vitamin D3, allantoin, calcium gluconate, amino acids and collagen; And the rest of the invention relates to a pet oral and dental protection play equipment capable of periodically injecting a liquid composition having a viscosity of 700 ~ 4000cps and a pH of 5.5-7. The composition maintains the cleanliness and health of the teeth and mouth of the animal, and is edible.
Description
본 발명은 애완동물의 구강 및 치아 보호용 놀이기구에 관한 것으로, 좀 더 구체적으로는 애완동물의 치아, 치간, 구강점막의 청결과 잇몸마사지 및 스트레스 해소의 목적을 위하여 애완동물이 사람의 힘을 빌리지 않고 동물 혼자 스스로 씹으므로 하여 구강 및 치아의 청결을 유지할 수 있도록 한 애완동물의 구강 및 치아 보호용 놀이기구에 관한 것이다.The present invention relates to a pet's oral cavity and tooth protection play, and more specifically to the pet's teeth, interdental, oral mucosa cleanliness and gum massage and the purpose of relieving stress, the pet borrows the power of a person The present invention relates to a pet's oral cavity and tooth protection play equipment, which allows the animal to chew on its own and maintains cleanliness of the oral cavity and teeth.
충치(dental caries; 치아우식증)는 인류가 오래 전부터 고민해온 질환중의 하나로 일상적 감미료인 설탕이 이용되면서 발병율이 증가하고 있으나, 자연의 동물들에게는 충치가 발병되지 않았다. 그러나 최근 설탕이 함유된 사람의 간식류를 즐겨 먹이거나 인공사료의 보급으로 애완동물의 충치 발병률이 증가하고 있는 추세이다.Dental caries (dental caries) is one of the diseases that humans have long been concerned about, and the incidence rate has increased with the use of sugar, a common sweetener, but caries have not occurred in nature. Recently, however, the incidence of dental caries is increasing due to the enjoyment of sugar-containing snacks or the supply of artificial feeds.
일반적으로 충치는 치아의 파괴를 동반한 감염성 질환으로 치구(齒垢; 치아세균막; dental plaque)내 세균, 음식물, 타액의 상호 작용에 의해 유발되는 다인성 질환이다. 치구내 세균 중에서도 스트랩토코쿠스 뮤탄스 [Streptococcus mutans(S. mutans)]가 주 원인균이며, 치면에 부착, 증식 및 산 생성 과정을 거쳐 치아우식을 유발한다. 즉, 충치균(S. mutans)은 치면의 피막에 부착한 후 자신이 생산하는 글루코실트랜스퍼라제(glucosyltransferase(Gtase)에 의하여 음식물 중의 자당(sucrose)으로부터 과당 폴리머(glucose polymer)인 불용성 글루칸(glucan)을 합성한다. 이 불용성 글루칸(glucan)은 거의 대부분이 α-1,3 결합으로 구성되어 있다고 보고되고 있다. 합성된 글루칸(glucan)은 치면에서 증식하는 세균간의 결합을 증가시키며, 이렇게 치면에 부착한 충치균은 치면에 자리잡고 당질 대사과정에서 젖산(lactic acid) 등 유기산을 생성하여 치아의 에나멜질을 탈회(decalcification)시켜 충치를 유발한다.In general, tooth decay is an infectious disease accompanied by destruction of teeth and is a multifactorial disease caused by the interaction of bacteria, food, and saliva in the dental plaque. Among the dental plaques, Streptococcus mutans ( S. mutans ) is the main causative bacterium and causes dental caries through adhesion, proliferation, and acid production. In other words, S. mutans are insoluble glucans, which are fructose polymers from sucrose in food by glucosyltransferase (Gtase) produced by themselves after attaching to the coating of the tooth surface. This insoluble glucan is reported to be composed almost exclusively of α-1,3 bonds.The synthesized glucan increases the bonds between bacteria that grow on the tooth surface and thus adheres to the tooth surface. One tooth decay bacteria are located on the tooth surface and produce organic acids such as lactic acid during carbohydrate metabolism to decalcify tooth enamel and cause tooth decay.
치석(齒石; dentalis lapis)은 충치의 원인임과 동시에 치주염을 일으키는 가장 큰 원인이 되기도 한다. 치은, 즉, 잇몸에 염증이 국한된 경우에는 치은염이며, 더욱 진행된 상태로 치주조직, 특히 치조골에 이미 염증이 확산된 상태라면 치주염이다. 플라그가 석회화되면 치석이 되는데 이는 파괴양상을 더욱 가속화시키는 요소로 작용한다. 또한 세균성 플라그는 치은염을 일으키는 주범이며 만성 치은염은 치주염을 초래한다.Dentalis lapis is a cause of tooth decay and the biggest cause of periodontitis. If gingivitis, ie, inflammation of the gums, is limited to gingivitis, it is a periodontitis if the inflammation has already spread to the periodontal tissue, especially the alveolar bone. When plaque is calcified, it becomes calculus, which acts to accelerate the destruction. Bacterial plaques also cause gingivitis and chronic gingivitis causes periodontitis.
한편, 동물의 구강 및 치아는 음식물 취식 등으로 인해 구강내 잔류물 및 불결해진 구강을 동물 혼자 스스로 청결하게 할 수 없음은 물론, 특히 동물의 구강과 치아는 적절한 영양섭취와 맛을 보거나 호흡만을 위해 활용되는 것이 아니라, 물건을 이동시키거나 대상물을 깨물거나 스스로의 몸에 묻어 있는 것을 핥는 등의 행위들을 하므로 사람의 손에 해당되는 일 이상의 행위들이 이를 통하여 이루어진다. 그리고 이러한 행위들이 청결한 대상물에서만 국한되는 것이 아니라, 여러 가지 질병의 원인이 되는 유해미생물들이 묻어있는 비위생적인 대상물의 맛을 보거나 옮기거나 핥거나 하여 질병의 원인이 되고 있다.On the other hand, the animal's mouth and teeth are not able to clean the residue and dirty mouth in the mouth alone due to food intake, etc., in particular, the mouth and teeth of the animal is only for proper nutrition and taste or breathing Rather than being used, it does things like moving things, biting objects, or licking things that are buried in one's own body. And these acts are not limited to clean objects, but they cause the disease by tasting, transferring, or licking the unsanitary objects that contain harmful microorganisms that cause various diseases.
동물은 이러한 자신의 치아 및 구강 관리를 위해 스스로 양치를 하지 못함은 물론, 이를 사람이 대신하여 주는 것도 쉬운 일이 아니며 또한, 그 자체를 싫어한다. 설사 어떠한 방법으로 양치를 하였더라도 양치한 치약을 헹구어 내거나 뱉어 내지 못하고 삼켜 버린다.Animals do not brush their teeth for their own teeth and oral care, and it is not easy for humans to replace them, and they do not like it themselves. Even if you brush your teeth, you can't rinse or spit your toothpaste.
이를 위하여 기존의 동물용 치약은 치아 청결을 위한 치약의 조성물로서는 연마제, 유연제, 쓴맛을 중화시킬 목적의 감미제, 구취를 중화시킬 목적의 향료와 점도조정제로 혼합 구성되어져 있으나, 프라그(plaque)의 일부는 연마제를 통하여 다소 제거가 가능할 수 도 있으나 이것마저도 매일 양치해야될 매 시기마다 사용이 불편하고 동물이 싫어하여 결론적으로 지속적이지 못한 사용으로 인하여 그 효과는 기대 할 수 없으며, 동물의 구강내 청결과 유해미생물 제거, 치주염, 구취, 프라그(plaque) 제거에 효과적이지 못한 단점이 있다.To this end, the conventional toothpaste for tooth cleaning is composed of a toothpaste composition for cleaning teeth, including an abrasive, a softening agent, a sweetening agent for neutralizing bitter taste, a fragrance and a viscosity adjusting agent for neutralizing bad breath, but a part of plaque May be somewhat removed through abrasives, but even this is inconvenient to use every time it needs to be brushed every day and consequently the effect is not expected due to inconsistent use. There are disadvantages in that it is not effective in removing harmful microorganisms, periodontitis, bad breath, and plaque.
이러한 문제점을 해결하기 위하여 한국 공개특허 제93-3880호에서는 애완동물의 치아의 청소와 질병발생 방지 목적으로 씹을 수 있도록 만들어진 애완동물용 치약을 개시하고 있다. 상기 치약은 동물 구강크기에 알맞은 크기와 모양으로된 중심부분은 부서지지 않는 견고한 다공성의 탄성 개구 쎌(cell)로 구성되고, 각 쎌에는 수용성 향수와 치약이 포함된 포옴(foam)이 포화되어 있고, 중심모양을 단단하게 덮고 있는 재킷은 탄성 치아-플로싱(flossing) 트레드(thread)로 그물조직으로 이루어져 있으며, 각 네트에는 동물치아가 통과할 수 있는 충분한 크기의 구멍이 다수 있으며 치아가 네트의 구멍을 통과할 때마다 치아가 플로싱될 수 있다.In order to solve this problem, Korean Patent Laid-Open Publication No. 93-3880 discloses a pet toothpaste made to chew for the purpose of cleaning the teeth of a pet and preventing disease occurrence. The toothpaste is composed of a solid porous elastic opening cell that is not broken in size and shape suitable for animal oral size, and each foam is saturated with a foam containing water-soluble perfume and toothpaste. The jacket, which tightly covers the central shape, consists of a net with elastic teeth-flosing treads, each of which has a number of holes of sufficient size for the animal teeth to pass through. The tooth may flow each time it passes through the hole.
그러나, 상기 중심부분이 견고한 다공성의 탄성 개구 셀(cell)과 중심모양을 단단하게 덮고 있는 재킷으로 구성되어, 그 셀속에 동물의 치아가 통과하기가 힘들뿐만 아니라 통과되더라도 치아가 셀속에서 잘 빠지지 않거나 셀과 셀을 덮고 있는 재킷의 견고함 때문에 동물의 치아가 상하거나 치아와 잇몸이 만나는 바로 위부분의 잇몸이 상하게 될 수 있다. 또한, 치간 깊숙한 곳까지 청소가 되지 않는 단점이 있으며, 수용성의 치약이 셀속에 미리 포함되어 있어 셀속에 있는 치약이 그 수명을 다 하였을 때는 셀속에 치약을 재 주입하기에는 불가능한 단점이 있다.However, the central part is composed of a rigid porous elastic opening cell and a jacket that tightly covers the center shape, and it is difficult for the animal's tooth to pass through the cell, and the tooth does not fall out of the cell even if passed. Due to the firmness of the cell and the jacket covering it, the animal's teeth may be damaged or the gum just above the tooth and gum contact may be damaged. In addition, there is a disadvantage that can not be cleaned up to the deep interdental, water-soluble toothpaste is included in the cell in advance, the toothpaste in the cell has the disadvantage that it is impossible to re-inject toothpaste into the cell when the life span.
이에 본 발명에서는 상술한 문제점을 해결하기 위해 광범위한 연구를 수행한 결과, 충치유발균인 뮤탄스균(S. Mutans)의 성장을 억제하고 치아 표면의 세균막인 프라그(치면세균막) 형성을 감소시키며 프라그 내에서의 산생성을 감소시켜 충치의 예방할 수 있는 애완동물의 구강 및 치아 보호용 액상조성물을 개발하였고, 본 발명은 이에 기초하여 완성되었다.Therefore, in the present invention, as a result of extensive research in order to solve the above-mentioned problems, it inhibits the growth of S. Mutans, which is a caries-causing bacterium, reduces the formation of plaque (geological membrane), which is a bacterial film on the tooth surface, To reduce the acid production in the development of a liquid composition for protecting the oral cavity and teeth of the pet to prevent caries, the present invention was completed based on this.
따라서, 본 발명의 목적은 애완동물의 치아, 치간, 구강점막의 청결과 잇몸마사지 및 스트레스 해소의 목적을 위하여 동물이 사람의 힘을 빌리지 않고 동물 혼자 스스로 씹으면서 양치하도록 하여 구강내 청결을 유지할 수 있는 식용이 가능한 애완동물의 구강 및 치아 보호용 놀이기구를 제공하는데 있다.Accordingly, an object of the present invention is to maintain the cleanliness of the oral cavity by allowing the animal to chew on its own by chewing on its own, without borrowing the power of the person for the purpose of cleaning the teeth, interdental, oral mucosa of the pet and relieving gum massage and stress. To provide a edible pet oral and dental rides.
삭제delete
상기 목적을 달성하기 위한 본 발명의 애완동물의 구강 및 치아 보호용 놀이기구는 내부 충진물과 이를 밀봉시키며 소정의 형상을 갖는 외피로 구성되고, 상기 내부 충진물은 스폰지의 기공 또는 화학솜의 조밀도가 0.02g/㎤내지 0.20g/㎤인 다공성 및 연질인 스폰지 또는 화학솜이며, 상기 외피는 그물망 또는 레이스 뜨기 한 합성섬유로 이루어지며, 상기 내부 충진물에 자이리톨 10 내지 50중량부; 키토산 0.05 내지 20중량부; 비타민 B2, 비타민 B6, 비타민 D3, 알란토인, 글루콘산칼슘, 아미노산 및 콜라겐으로 이루어진 군으로부터 하나 또는 그 이상 선택된 성분 0.001 내지 6중량부; 및 나머지는 물을 포함하며, 700∼4000cps의 점도 및 5.5∼7의 pH를 갖는 액상조성물의 주기적으로 주입이 가능한 것으로 구성된다.Oral and dental care play equipment for pets of the present invention for achieving the above object is composed of the inner packing and the outer sheath having a predetermined shape, the inner filling is 0.02 in the density of the pores or chemical cotton of the sponge g / cm 3 to 0.20 g / cm 3 of porous and soft sponge or chemical cotton, wherein the outer shell is made of a mesh or laced synthetic fiber, and 10 to 50 parts by weight of ziritol in the inner filling; Chitosan 0.05 to 20 parts by weight; 0.001 to 6 parts by weight of one or more components selected from the group consisting of vitamin B2, vitamin B6, vitamin D3, allantoin, calcium gluconate, amino acids and collagen; And the remainder comprises water, capable of periodically injecting a liquid composition having a viscosity of 700 to 4000 cps and a pH of 5.5 to 7.
삭제delete
이하 본 발명을 첨부된 도면을 참조하여 더욱 구체적으로 살펴보면 다음과 같다.Hereinafter, the present invention will be described in more detail with reference to the accompanying drawings.
전술한 바와 같이, 본 발명에 따른 애완동물의 구강 및 치아 보호용 액상조성물은 자일리톨; 키토산; 및 비타민 B2, 비타민 B6, 비타민 D3, 알란토인, 글루콘산칼슘, 아미노산 및 콜라겐으로 이루어진 군으로부터 하나 또는 그 이상 선택된 성분을 필수 성분으로 함유하고, 밸런스 성분으로 물을 포함하며, 습윤제, 향료 및/또는 색소를 더욱 포함 할 수 있다.As described above, the liquid composition for oral cavity and tooth protection of a pet according to the present invention is xylitol; Chitosan; And one or more ingredients selected from the group consisting of vitamin B2, vitamin B6, vitamin D3, allantoin, calcium gluconate, amino acids and collagen as essential ingredients, water as balance ingredients, wetting agents, flavoring agents and / or It may further include a pigment.
한편, 본 발명에 사용된 애완동물은 사람이 애완을 목적으로 집에서 기르는 동물을 총칭하며, 대표적으로 개와 고양이이나, 이에 한정되는 것은 아니다.On the other hand, the pet used in the present invention is a generic term for animals raised by a person at home for the purpose of pets, typically dogs and cats, but is not limited thereto.
본 발명에 사용되는 자일리톨은 키실리톨이라 부르기도 하며 키실로오스를 환원하여 얻는 5탄당 알콜로서 흰색의 결정성 분말로 무취이며 물에 잘 녹는다. 최근에 무설탕 과자나 초콜릿 등의 제조에 사용되는 신규 감미료 중의 하나이며 구강미생물에 의해 발효하지 않기 때문에 치아우식증을 일으키지 않는다. 설탕의 0.9∼1.0배 정도의 단맛을 가지며 청량감이 있다. 독성은 거의 없고(포도당과 같은 수준) 과다 섭취할 경우에는 설사를 하는 수가 있으며 1g당 3.57kcal의 열량을 발생한다. 또한 충치균의 성장을 억제해 프라그의 형성을 감소시키고 프라그에서 산의 생산을 억제하기도 하며 법랑질에서 광물질이 이탈하는 현상을 방지하는 작용을 하여 준다.The xylitol used in the present invention is also called xylitol and is a pentose alcohol obtained by reducing xylose, which is odorless as a white crystalline powder, and soluble in water. Recently, it is one of the new sweeteners used in the production of sugar-free confectionery and chocolate, and does not cause dental caries because it is not fermented by oral microorganisms. It has a sweet taste of about 0.9 to 1.0 times the sugar and has a refreshing feeling. Very little toxicity (equivalent to glucose) and overdose can cause diarrhea and produce 3.57 kcal per gram of calories. In addition, it inhibits the growth of caries, reduces the formation of plaque, inhibits the production of acid in the plaque, and acts to prevent the release of minerals from enamel.
본 발명에 있어서, 상기 자일리톨의 사용량은 10 내지 50중량부가 바람직한데, 10중량부 미만이면 본래 목적하는 약리 효과가 발휘 될 수 없으며, 50중량부를 초과하면 과다한 단맛과 열량발생 및 설사를 초래하는 경향이 있다.In the present invention, the amount of xylitol is preferably used in an amount of 10 to 50 parts by weight, but less than 10 parts by weight can not exert its intended pharmacological effect, and when it is more than 50 parts by weight, excessive sweetness, calories and diarrhea tend to result. There is this.
본 발명에 사용되는 키토산은 갑각류, 게껍질에 함유된 폴리-β-1,4-N-아세틸-D-글루코사민으로 구성된 다당류인 키틴의 탈아세틸 유도체인 바, 강력한 식이섬유이며 고분자 일 때 그 기능을 발휘한다. 키토산은 식물 속에 들어있는 셀룰로스와 유사한 섬유질이며 체내의 모든 노폐물들을 배설시키며 각 조직 세포들을 활성화시키는 기능을 가지고 있다. 다시말하면 섬유질인 키토산은 이리저리 꼬여서 엉성한 솜뭉치처럼 되어 있어서 다른 물질들을 휘감아서 끌고 나가기에 적합한 구조를 가지고 있으며, 특히 키토산은 셀룰로스와는 달리 양이온인 아미노기를 가지고 있어서 음이온을 띤 유해물질을 강력하게 붙잡아 배출한다. 이러한 키토산은 친유성이면서 보습성을 갖고 있는 무정형 분말로서 인체에 무해하고 체내의 유효균 생육을 촉진하면서도 대장균 등의 유해균에 대하여는 강력한 항균작용을 한다.Chitosan used in the present invention is a deacetyl derivative of chitin, a polysaccharide composed of crustaceans and poly-β-1,4-N-acetyl-D-glucosamine contained in shells. Exert. Chitosan is a cellulose-like fiber in plants that excretes all the waste products in the body and has the function of activating individual tissue cells. In other words, the fibrous chitosan is twisted around and shaped like a wad of wool, and has a structure suitable for enclosing and pulling out other substances.In particular, the chitosan has an amino group, which is a cation, unlike cellulose, and thus strongly captures an anion-containing harmful substance. Discharge. The chitosan is an lipophilic and moisturizing amorphous powder, which is harmless to the human body and promotes the growth of effective bacteria in the body, while also acting as a powerful antibacterial agent against harmful bacteria such as Escherichia coli.
키틴은 셀룰로우스와 유사한 구조를 갖고 있으면서도 셀룰로우스와는 물리적인 특성이 다르고 물이나 유기용매에는 물론이고 묽은 산과 알카리에도 잘 용해되지 아니하는 다당류 분말상 물질이며, 본 발명에 사용되는 키틴의 탈아세틸 유도체인 키토산은 묽은 산용액에 용해하는 물질이다. 이러한 키토산은 그 자체가 갖고 있는 항균작용으로 미생물의 발생을 방지하여 충치를 예방하고 구취를 흡착 및 제어하여 구강내 개운한 느낌이 오래 유지되게 한다.Chitin is a polysaccharide powdery substance that has a structure similar to cellulose but has different physical properties from cellulose and is insoluble in water or organic solvents, as well as in dilute acids and alkalis, and deacetylation of chitin used in the present invention. Chitosan, a derivative, is a substance that is dissolved in dilute acid solution. Such chitosan has its own antibacterial action, which prevents the generation of microorganisms, prevents tooth decay, and absorbs and controls bad breath so that the fresh feeling in the mouth is maintained for a long time.
따라서, 키토산이 갖고 있는 유해균에 대한 강력한 항균작용에 의하여 구강 미생물의 발생을 방지할 수 있으며, 미생물의 번식을 억제하는 키토산 특유의 항균 효과는 충치염, 치주, 치은염의 방지를 효과적으로 달성하고 또한 키토산의 첨가로 인하여 조성물에 방부제를 첨가하지 않으므로서 기존의 치약 제조시에 사용되는 방부제 및 살균제의 과다투여로 인하여 발생되는 구강점막 및 생체에 대한 부작용 등을 최소한으로 줄이면서 기존의 방부 및 살균력을 높히고 사용시에 치약에서 방부제로 인한 역겨운 약품냄새가 발생하지 않게 되어 애완동물의 기호에 적합하며, 장기 보관하여도 미생물에 의해 부패되지 않는다. 그리고 키토산에 의해 구취를 흡착 및 제어하여 구강내에 개운한 느낌을 오래 유지시킬 수 있다. Therefore, it is possible to prevent the generation of oral microorganisms by the strong antibacterial action against harmful bacteria possessed by chitosan, and the unique antibacterial effect of chitosan that suppresses the growth of microorganisms effectively achieves the prevention of caries, periodontal and gingivitis and also chitosan. Due to the addition of the preservatives without adding preservatives to the composition, while reducing the side effects on the oral mucosa and living body caused by the overdose of the preservatives and fungicides used in the existing toothpaste manufacturing to increase the existing preservation and sterilization power When used, toothpaste does not cause disgusting chemical smell due to preservatives, so it is suitable for pet's taste and does not rot by microorganisms even after long-term storage. In addition, it is possible to maintain a fresh feeling in the mouth by adsorbing and controlling bad breath by chitosan.
상기 키토산의 사용량은 0.05 내지 20중량부가 바람직한데, 0.05중량부 미만이면 프라그 감소 작용 및 항균효과가 부족한 문제가 있고, 20중량부를 초과하면 경제적으로 불리한 단점이 있다.The amount of chitosan is preferably 0.05 to 20 parts by weight, but less than 0.05 parts by weight, there is a problem of a lack of plaque reduction action and antimicrobial effect, and more than 20 parts by weight has an economic disadvantage.
본 발명에 따르면, 상기 비타민 B2, 비타민 B6, 비타민 D3, 알란토인, 글루콘산칼슘, 아미노산 및 콜라겐으로 이루어진 군으로부터 하나 또는 그 이상 선택된 성분은 치아 및 구강점막의 영양공급과 항염 및 항균작용의 목적으로 사용된다. 상기 성분의 사용량은 0.001∼6중량부의 범위가 바람직한데, 0.001중량부 미만으로 사용하면 항균효과 및 구취 흡착 제어 효과가 떨어지고, 6중량부를 초과하면 체내 필요이상의 과잉 영양섭취 현상 등을 초래할 수 있음과 아울어 생산비의 상승을 가져오는 단점이 있다.According to the present invention, one or more components selected from the group consisting of the vitamin B2, vitamin B6, vitamin D3, allantoin, calcium gluconate, amino acids and collagen are used for the purpose of nutrition and anti-inflammatory and antibacterial action of the teeth and oral mucosa. Used. The amount of the component is preferably in the range of 0.001 to 6 parts by weight, the use of less than 0.001 parts by weight of the antimicrobial effect and bad breath control effect, and exceeding 6 parts by weight can cause excess nutrition intake in the body and In addition, there is a disadvantage that leads to an increase in production costs.
상기 비타민 B2는 수용액 중에서 황록색 형광을 띠는 오렌지색 또는 노란색 결정체로서 리보플라빈이라고 불린다. 비타민 B2는 체내에서 탈수소효소의 조효소인 FMN(flavin mononucleotide)과 FAD(flavin adenine dinucleotide)의 구성성분이 된다. 이 탈수소효소는 어떤 물질로부터 수소를 받아서 다른 물질로 운반하여 결국 열량소로부터의 수소가 산소와 결합하여 물이 되도록 하는 생체의 산화·환원 반응계에서 작용하는 여러 효소들에 속한다. 그러므로 비타민 B2는 탄수화물·지방·단백질 등 열량소의 대사에 없어서는 안되며, 만일 결핍되면 이들의 대사가 저해되어 여러 가지 신체장애를 일으킨다. 결핍증으로서 설염·구순염·구각염·피부병·결막염이나 백내장 같은 눈병이 나타난다.The vitamin B2 is called orange riboflavin as an orange or yellow crystal which is yellowish green in an aqueous solution. Vitamin B2 is a component of the dehydrogenase coenzyme, FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide). These dehydrogenases belong to a number of enzymes that work in the body's redox reaction system, which receives hydrogen from a substance and transports it to another substance, which eventually combines hydrogen from the caloric hydrogen with water to form water. Therefore, vitamin B2 is indispensable for the metabolism of calories such as carbohydrates, fats and proteins, and if deficient, their metabolism is inhibited and causes various physical disorders. As a deficiency, eye diseases such as sulphitis, cleft lipitis, stomatitis, skin disease, conjunctivitis and cataracts appear.
비타민 B6은 비타민 B6의 효력을 나타내는 모든 물질을 총칭하는 이름으로서 피리독신(pyridoxine), 피리독살(pyridoxal) 및 피리독사민(pyridoxamine)이 여기에 속한다. 생체내에서 비타민 B6는 피리독살이 한 분자의 인산과 결합한 형태인 피리독살인산으로 되어 영양소대사에 조효소로 작용한다. 특히 아미노산으로부터 다른 케토산으로의 아미노기의 전이, 황을 함유하는 아미노산으로부터 SH군의 제거, 아미노산으로부터 이산화탄소의 제거 및 아미노기의 제거 등 생체 내 반응의 효소에 대한 조효소로 아미노산과 단백질대사에 광범위하게 작용한다. 결핍증세는 니코틴산이나 비타민 B2 결핍증세와 비슷하다. 즉, 초기에는 눈 주위·눈썹·입가장자리·혀의 염증으로 시작하여 현기증·구토·체중감소·정신불안·빈혈·신석·경련 등의 증세로 진행된다.Vitamin B6 is a generic name for all substances that show the effects of vitamin B6, and pyridoxine, pyridoxal and pyridoxamine belong to it. In vivo, vitamin B6 acts as a coenzyme for nutrient metabolism by becoming pyridoxal phosphate, a form in which pyridoxal is bound to one molecule of phosphoric acid. In particular, it acts extensively on amino acids and protein metabolism as a coenzyme for enzymes in vivo reactions, such as the transition of amino groups from amino acids to other keto acids, the removal of SH groups from sulfur-containing amino acids, the removal of carbon dioxide from amino acids, and the removal of amino groups. do. Deficiency is similar to nicotinic acid or vitamin B2 deficiency. In other words, it begins with inflammation around the eyes, eyebrows, lip, and tongue, and progresses to dizziness, vomiting, weight loss, mental anxiety, anemia, kidney stones, and convulsions.
이와 같이, 본 발명의 조성물은 치아 및 구강점막의 영양공급원으로 비타민 B6 및/또는 비타민 B2을 포함한다.As such, the compositions of the present invention comprise vitamin B6 and / or vitamin B2 as a nutritional source of teeth and oral mucosa.
한편, 비타민 D3는 칼슘 흡수에 필요한 단백질(Calcium-Binding Protein)의 합성을 자극함으로써 장에서 칼슘과 인의 흡수를 촉진시키며, 또한 혈액의 칼슘과 인의 농도가 증가되면 칼슘과 인을 결합시켜 뼈에 침작시키는 작용을 한다. 따라서 비타민 D3가 결핍되면 뼈의 주성분이 칼슘과 인의 화합물 인산칼슘이 정상적으로 침작되지 않아 치아의 석회화가 좋지 않게 되어 인산칼슘의 침작을 촉진하게 되고 이로인해 구루병, 골연화증(Osteomalacia)이 유발 및 충치발생과 구강질병 등이 나타나게 된다.On the other hand, vitamin D3 stimulates the synthesis of calcium-binding protein, which promotes the absorption of calcium and phosphorus in the intestine, and increases calcium and phosphorus concentrations in the blood to bind calcium and phosphorus to invade bone. To act. Therefore, if vitamin D3 is deficient, calcium and phosphorus compound calcium phosphate of bone is not normally precipitated, which leads to poor calcification of teeth, which promotes calcium phosphate seizure, which causes rickets, osteomalacia and tooth decay. Oral disease, etc. will appear.
상기 알란토인(Allantoin)은 컴프리 뿌리 추출물(Comfrey Extract)으로서 비타민 D3의 상승작용과 상기 증상들을 비롯한 노령의 동물에서 자주 발생되는 잇몸의 출혈방지, 종창개선의 효과, 잇몸염증, 궤양회복, 자극완화, 치주염, 치은염 예방에 효과가 있다.The allantoin is a Comfrey Extract, a synergistic action of vitamin D3 and the effects of bleeding prevention, swelling improvement, gum inflammation, ulcer recovery, stimulation, It is effective in preventing periodontitis and gingivitis.
한편, 글루콘산 칼슘은 글루콘산 염의 한 형태로서, 이들 염은 구강 질환과 관련된 의약품으로도 사용된다. 당대사의 중간체로서 6-인산에스테르의 형태로 생체 내에 존재한다.Calcium gluconate, on the other hand, is a form of gluconate salt, which is also used as a medicine related to oral diseases. It is present in vivo in the form of 6-phosphate ester as an intermediate of sugar metabolism.
또한, 콜라겐은 동물의 뼈·연골·치아·건(腱)·피부 외에 물고기의 비늘 등을 구성하는 경단백질(硬蛋白質). 교원질(膠原質)로서, 섬유상 고체로 존재하고, 복잡한 가로무늬 구조로 되어 있다. 물·묽은 산·묽은 알칼리에 녹지 않지만 끓이면 젤라틴이 되어 용해된다. 트립신 등 단백질 분해 효소의 작용은 받기 어렵고, 콜라게나아제의 작용을 받는다. 뼈는 하이드록시아파타이트 결정과 유기조직의 나노구조물인데, 여기에서 딱딱한 결정상태의 하이드록시아파타이트는 가해진 에너지를 잘 분산시키지 못하기 때문에 주로 유기조직인 콜라겐이 그 역할을 맡게 된다. 콜라겐은 뼈, 힘줄, 피부와 같은 다양한 조직에 탄력성을 부여하는 역할을 한다. 그리고 일반적으로 콜라겐 사이의 교차결합의 수가 감소하면 뼈 또는 치아의 강도도 감소하게 된다.Collagen is a light protein that makes up the scales of fish in addition to bones, cartilage, teeth, tendons and skin of animals. As a collagen, it exists as a fibrous solid and has a complicated horizontal pattern structure. Insoluble in water, dilute acid, and dilute alkali, but when boiled, becomes gelatin and dissolves. The action of proteolytic enzymes, such as trypsin, is difficult to receive and is affected by collagenase. Bone is a nanostructure of hydroxyapatite crystals and organic tissues, where the hard crystalline hydroxyapatite does not disperse the applied energy well, mainly because organic collagen plays a role. Collagen gives elasticity to various tissues such as bones, tendons and skin. In general, decreasing the number of crosslinks between collagens also reduces bone or tooth strength.
상기 아미노산은 단백질을 이루는 기본성분으로서 글리코콜(glycocoll) 또는 아미노아세트산이라고도 한다. 상기 아미노산은 물에는 녹으나, 알코올 ·에테르 등의 유기용매에는 거의 녹지 않는다. 아미노산 중에서 비대칭 탄소원자를 가지지 않는 유일한 것으로, 광학이성질체는 없으며, 감미가 있어 글리코콜이라고 칭한다. 단백질은 모든 세포조직의 성장과 발달, 유지 및 보수에 필요한 기본 물질로서 호르몬, 효소, 항체 및 신경 전달 물질을 만드는데 사용되며 산, 알칼리 평형을 유지시키고 DNA, RNA 구성성분의 전구체가 되며 열량 공급도 한다. 천연에서 얻을 수 있는 아미노산의 대부분은 α-아미노산이며 이것이 서로 물분자를 잃어 펩타이드 결합을 형성한 것이 펩타이드와 단백질이다. 아미노산은 생체의 기본 화합물이고 단백질을 구성하고 있는 것 외에 호르몬, 신경전달물질의 역할을 한다.The amino acid is also called glycocoll or aminoacetic acid as a basic component of a protein. The amino acid is soluble in water, but hardly soluble in organic solvents such as alcohol and ether. The only amino acid that does not have an asymmetric carbon atom, there is no optical isomer, it is called glycocol because of its sweetness. Protein is a basic substance necessary for the growth, development, maintenance and repair of all tissues. It is used to make hormones, enzymes, antibodies and neurotransmitters. It maintains acid and alkali equilibrium, becomes a precursor of DNA and RNA components, and supplies calories. do. Most of the amino acids that can be obtained in nature are α-amino acids, which are peptides and proteins that lose water molecules to each other to form peptide bonds. Amino acids are the basic compounds of the living body and make up proteins as well as hormones and neurotransmitters.
이와 같이, 상술한 조성을 갖는 본 발명의 조성물은 충치유발균인 뮤탄스균(S. Mutans)의 성장을 억제하고 치아 표면의 세균막인 프라그(치면세균막) 형성을 감소시키며 프라그 내에서의 산생성을 감소시킬 수 있다.As such, the composition of the present invention having the above-described composition inhibits the growth of S. Mutans, which is a caries-inducing bacterium, reduces the formation of plaque, which is a bacterial film on the tooth surface, and reduces acid production in the plaque. You can.
본 발명에 따르면, 상기 조성물은 구강 점막내 보습의 목적으로 솔비톨, 글루코스, 글리세린 및 이들의 혼합물로 이루어진 군으로부터 선택된 습윤제를 더욱 포함할 수 있다. 상기 습윤제의 사용량은 구강 점막보호 및 건조증 예방의 목적으로 상기 조성물 100중량부에 대하여 1 내지 20중량부가 바람직하다. 또한, 본 발명의 조성물은 식용 색소 및/또는 식용향료를 더욱 포함하여 색상 및 냄새로 애완동물의 유도할 수 있다.According to the invention, the composition may further comprise a humectant selected from the group consisting of sorbitol, glucose, glycerin and mixtures thereof for the purpose of moisturizing the oral mucosa. The amount of the wetting agent is preferably 1 to 20 parts by weight based on 100 parts by weight of the composition for the purpose of protecting the oral mucosa and preventing dryness. In addition, the composition of the present invention may further include food coloring and / or food flavoring to induce the pet to the color and smell.
한편, 본 발명의 조성물은 방부제로는 안식향산나트륨, 소르빈산칼륨 및 이의 혼합물을 선택적으로 사용할 수 있으며, 점도조정을 위하여 셀룰로오스검, 산탄검, 하이드록시에칠셀룰로오스 및 이의 혼합물을 선택적으로 사용할 수 있으며, pH조정제를 더욱 포함할 수 있는데 이들 모두는 식이성을 전제로 하여야 한다.Meanwhile, the composition of the present invention may optionally use sodium benzoate, potassium sorbate and mixtures thereof as a preservative, and optionally use cellulose gum, xanthan gum, hydroxyethyl cellulose and mixtures thereof for viscosity adjustment. pH adjusters may be further included, all of which must be dietary.
상기 성분들을 균질 혼합하여 조성된 본 발명의 조성물은 700∼4000cps의 점도와 5.5∼7의 pH를 가지며, 식용이 가능하다. 상기에서 점도가 700cps 미만일 경우는 후술하는 애완동물용 놀이기구에 주입시 쉽게 흘러내리는 단점이 있으며, 4000cps를 초과하면 점성이 높아 사용에 불편한 단점이 있다. 아울러, 상기 조성물의 pH조정은 구강점막내 피부의 알칼리 중화능 및 pH 완충 작용면에서 5.5∼7이 바람직하다.The composition of the present invention prepared by homogeneous mixing of the components has a viscosity of 700 to 4000cps and a pH of 5.5 to 7, and is edible. If the viscosity is less than 700cps, there is a disadvantage that easily flows down when injected into the pet rides to be described later, if the viscosity exceeds 4000cps has a disadvantage inconvenient to use. In addition, the pH adjustment of the composition is preferably 5.5 to 7 in terms of alkali neutralization capacity and pH buffering action of the skin in the oral mucosa.
도 1 및 2를 참조하면, 이렇게 얻어진 본 발명의 액상조성물은 내부 충진물(1)과 이를 밀봉시키며 소정의 형상을 갖는 외피(2)로 구성되고, 상기 내부 충진물은 다공성이고 연질인 스폰지 또는 화학솜(cotton of chemicals)이며, 상기 외피는 그물망 또는 레이스 뜨기 한 합성섬유로 이루어진 애완동물용 놀이기구에 주입시켜 사용한다.1 and 2, the liquid composition of the present invention thus obtained is composed of the inner filler (1) and the outer shell (2) having a predetermined shape sealing it, the inner filler is a porous or soft sponge or chemical cotton (cotton of chemicals), which is used by injecting into a pet ride made of a mesh or laced synthetic fibers.
상기 내부 충진물(1)은 본 발명에서의 역할과 기능이 동물의 치아, 치간의 기계적인 청소와 잇몸마사지를 직접적으로 수행하는 부분이며 또한 외부로부터 본 발명의 조성물이 주입되어 상기 조성물을 함유할 수 있는 부분이기도 하다. 좀더 상세하게는 본 발명에 따른 조성물에 의해 유도된 애완동물이 양치 행위에 해당되는 반복적 씹음으로 해서 동물의 치아가 내부 충진물(1)의 깊숙한 곳까지 도달되는 동작이 반복되며 이로 인하여 동물의 치아 등은 상기 내부 충진물(1)과 반복적 기계적인 마찰을 통하여 청결하게 된다.The internal filler 1 is a part of the role and function of the present invention to directly perform the mechanical cleaning and gum massage of the teeth, interdental of the animal, and also the composition of the present invention can be injected from the outside to contain the composition. It is a part of it. More specifically, the pet is induced by the composition according to the present invention by repeated chewing corresponding to the brushing action, the operation of reaching the depth of the animal's teeth deep inside the filling (1) is repeated, thereby Is cleaned through repeated mechanical friction with the internal filler (1).
이를 위하여 내부 충진물(1)은 놀이기구의 형상를 결정짓는 핵심부분으로서 크기(size)와 모양은 대상 동물의 구강 및 치아의 크기에 따라 알맞은 크기와 모양으로 된 것으로 이루어지도록 하면 바람직하며, 그의 재질로서는 동물 치아의 크기에 따라 기공의 크기가 적절한 크기로 선택된 다공성이고 연질인 스폰지 또는 화학솜(cotton of chemicals)이 바람직하다.To this end, the inner packing 1 is a key part for determining the shape of the play equipment. The size and shape of the inner filling material 1 are preferably made of a size and shape appropriate to the size of the mouth and teeth of the target animal. Porous and soft sponges or cotton of chemicals are preferably selected in appropriate sizes depending on the size of the animal teeth.
또한 본 발명의 외피(2) 부분은 동물의 구강점막 청소를 직접 수행하며, 내부 충진물(1)의 기능 보호를 위해 쉽게 해체되거나 부서지지 않도록 에워싸는 기능을 가진 보완적 기능을 담당하는 것으로서, 그 구성 및 재질로는 내부 충진물(1)의 외부 모두를 커버(cover)할 수 있으면서 대상 동물의 치아가 외피(2)를 쉽게 통과하여 내부 충진물(1)의 중심부분에 충분히 도달 되도록 하기 위하여 그물망 형태의 합성섬유이거나 합성섬유로 레이스 뜨기 한 것이면 바람직하며, 외피(2)가 해체 또는 손상되지 않도록 최종적으로 마무리 봉합한 것이 바람직하다.In addition, the outer shell (2) portion of the present invention performs a direct cleaning of the oral mucosa of the animal, and in charge of the complementary function having a function of encapsulating the function so as not to be easily disassembled or broken for protection of the internal filling (1), its configuration And the material can cover all of the outside of the inner packing (1) while the teeth of the target animal easily passes through the shell (2) of the net form in order to reach the central portion of the inner filling (1) sufficiently It is preferable that it is synthetic fiber or laced with synthetic fiber, and it is preferable that the final closure is finished so that the outer shell 2 is not disassembled or damaged.
본 발명에 있어서, 상기 외피(2)의 형상은 원구형 또는 뼈다귀형인 것이 바람직하나, 이에 한정되는 것은 아니며, 상기 스폰지의 기공 또는 화학솜의 조밀도(겉보기 비중)는 0.02g/㎤내지 0.20g/㎤가 바람직한데, 0.02g/㎤ 미만이면 조밀도가 너무 느슨하여 후래싱(freshing) 효과가 없으며, 0.20g/㎤ 이상이면 너무 조밀하여 본 조성물이 필요이상으로 낭비되는 단점은 물론, 치아 깊숙이 까지 쉽게 들어가지 않아 치아, 구강 및 점막을 후래싱시키기가 힘든 단점 있다. 또한, 상기 외피의 그물망 또는 레이스 뜨기의 셀(cell)의 크기는 0.20㎟ 내지 100㎟가 바람직하며, 이때 0.20㎟ 미만이면 너무 조밀하여 후래싱에 불리함과 레이스 뜨기에 불리하며, 100㎟를 초과하면 외피로서의 기능을 초과하여 스폰지 또는 화학솜을 보호하지 못하는 단점이 있다.In the present invention, the outer shell 2 preferably has a spherical shape or a bone shape, but is not limited thereto, and the density (apparent specific gravity) of the pores or chemical cotton of the sponge is 0.02 g / cm 3 to 0.20 g. / Cm3 is preferred, but less than 0.02g / cm3, the density is too loose, no freshing effect, and more than 0.20g / cm3, too dense, the composition is wasted more than necessary, of course, deep into the teeth There is a disadvantage that it is difficult to flash the teeth, mouth and mucous membranes because it does not enter easily. In addition, the size of the shell mesh or the cell of the lace knit is preferably from 0.20 mm 2 to 100 mm 2, where less than 0.20 mm 2 is too dense to be disadvantageous for flashing and to lace, more than 100 mm 2. There is a disadvantage in that it does not protect the sponge or chemical cotton over the function as the outer shell.
한편, 본 발명에 따른 수용성의 식용이 가능한 조성물을 상기 놀이기구의 내부 충진물(1)에 함유되도록 외부로부터 주입하여 동물의 반복적 씹는 동작이 내부 충진물(1)을 가압하고 이로 인하여 내부에 함유되어 있던 본 발명에 따른 조성물의 유출 및 마찰로 본 발명의 조성물이 달성하고자 하는 목적을 달성할 수 있다. 이때 상기 조성물은 놀이기구에 필요시 주입시키며, 1회 주입량은 동물의 구강 크기에 따라 놀이기구도 선택적으로 이루어 져야 하는 이유에서 적당한 량을 제시하기는 힘들지만, 0.01∼0.50㎖/㎤이 바람직하고, 좀 더 바람직하게는 0.10∼0.30㎖/㎤이다.On the other hand, by injecting the water-soluble edible composition according to the present invention from the outside to be contained in the internal filling (1) of the ride, the repeated chewing operation of the animal pressurizes the internal filling (1) and thereby was contained therein The outflow and friction of the composition according to the invention can achieve the object that the composition of the invention is intended to achieve. At this time, the composition is injected into the play equipment, if necessary, the single injection amount is difficult to present a suitable amount because the play equipment should also be made selectively according to the oral size of the animal, 0.01 ~ 0.50ml / ㎠ is preferred, More preferably, it is 0.10-0.30 ml / cm <3>.
이하 실시예를 통해 본 발명의 구성 및 효과에 대하여 좀 더 구체적으로 살펴보지만, 하기 예에 본 발명의 범주가 한정되는 것은 아니다.Hereinafter, the configuration and effects of the present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to the following examples.
실시예 1Example 1
자이리톨 30중량부, 키토산 0.1중량부, 비타민 B6 0.3중량부, 비타민 D3 0.001중량부, 알란토인 0.3중량부, 글루콘산칼슘 0.5중량부 및 정제수 적량을 균질하게 혼합하였고, 점도조정을 위하여 셀룰로오스검 1.2중량부를 첨가하여 약 2,770cps 정도의 점도와 pH 6.1을 갖는 본 발명의 애완동물의 구강 및 치아 보호용 액상조성물을 제조하였다.30 parts by weight of xyitol, 0.1 part by weight of chitosan, 0.3 part by weight of vitamin B6, 0.001 part by weight of vitamin D3, 0.3 part by weight of allantoin, 0.5 part by weight of calcium gluconate and a suitable amount of purified water were mixed homogeneously, and 1.2 weight of cellulose gum for viscosity adjustment. Part was added to prepare a liquid composition for oral and dental protection of the pet of the present invention having a viscosity of about 2,770cps and pH 6.1.
실시예 2Example 2
실시예 1에서 색소 0.005중량부와 향료 0.5중량부를 더욱 첨가시킨 것을 제외하고는 동일하게 실시하였고, 점도조정을 위하여 셀룰로오스검 1.2중량부를 첨가하여 약 2,700cps의 점도와 pH 6.2를 나타내었다.Except that in addition to 0.005 parts by weight of pigment and 0.5 parts by weight of perfume in Example 1 was carried out in the same manner, 1.2 parts by weight of cellulose gum was added for viscosity adjustment to show a viscosity of about 2,700 cps and pH 6.2.
실시예 3Example 3
실시예 1에서 솔비톨 4.0중량부와 글리세린 4.0중량부를 더욱 첨가시킨 것을 제외하고는 동일하게 실시하였고, 점도조정을 위하여 셀룰로오스검 1.0중량부를 첨가하여 약 2,750cps의 점도와 pH 6.2를 나타내었다.Except that the addition of 4.0 parts by weight of sorbitol and 4.0 parts by weight of glycerol in Example 1 was carried out in the same manner, and 1.0 parts by weight of cellulose gum was added for viscosity adjustment to show a viscosity of about 2,750 cps and pH 6.2.
실시예 4Example 4
실시예 3에서 색소 0.005중량부와 향료 0.5중량부를 더욱 첨가시킨 것을 제외하고는 동일하게 실시하였고, 점도조정을 위하여 셀룰로오스검 1.0중량%를 첨가하여 약 2,700cps의 점도와 pH 6.1을 나타내었다.Except that 0.005 parts by weight of pigment and 0.5 parts by weight of the flavor was further added in Example 3, 1.0 wt% of cellulose gum was added to adjust the viscosity to show a viscosity of about 2,700 cps and a pH of 6.1.
실시예 5Example 5
실시예 1에 따른 조성물을 도 1에 도시된 바와 같은 뼈다귀 형상의 놀이기구에 주사기를 통하여 5㎖를 주입하였다. 상기 놀이기구의 내부 충진물은 기공크기가 약 1g/㎤인 화학솜이고, 외피의 그물망의 구멍 크기는 4㎣이며, 놀이기구의 전체 용적은 75㎤의 크기였다.5 ml of the composition according to Example 1 was injected through a syringe into a bone-shaped play equipment as shown in FIG. 1. The interior filling of the ride was a chemical cotton with a pore size of about 1 g / cm 3, the pore size of the outer mesh was 4 mm 3, and the total volume of the ride was 75 cm 3.
실시예 6Example 6
실시예 5에서 실시예 1에 따른 조성물 대신에 실시예 2에 따른 조성물을 주입한 것을 제외하고는 동일하게 실시하였다.Except for injecting the composition according to Example 2 in place of the composition according to Example 1 in Example 5 it was carried out in the same manner.
실시예 7Example 7
실시예 5에서 실시예 1에 따른 조성물 대신에 실시예 3에 따른 조성물을 주입한 것을 제외하고는 동일하게 실시하였다.The same procedure was followed as in Example 5 except that the composition according to Example 3 was injected instead of the composition according to Example 1.
실시예 8Example 8
실시예 5에서 실시예 1에 따른 조성물 대신에 실시예 4에 따른 조성물을 주입한 것을 제외하고는 동일하게 실시하였다.The same procedure was followed as in Example 5 except that the composition according to Example 4 was injected instead of the composition according to Example 1.
각 실시예에 따른 평가방법은 다음과 같이 하였다.The evaluation method according to each example was as follows.
<대상동물의 선정><Selection of target animal>
7개월령의 애완용 슈나우즈종 개들 중에서 본 평가를 위하여 구강내현병력 및 시험평가를 확인하기 위하여 시진(inspection) 및 탐진(exploration)을 한 결과 현재 치태 및 구강병력이 없는 개 15마리를 시험대상 동물로 선정하였다.Among the 7-month-old pet Schnauzer dogs, 15 dogs without plaque and oral history were examined as the subjects after the examination and exploration to confirm the oral history and test evaluation. Selected.
<시험조건><Test conditions>
시험동물 15마리를 쾌적한 채광과 통풍이 제공되는 동일 공간 내에 적당한 운동량을 제공하면서 3개월(12주)간 일정량의 인공 사료를 급여하되 본 시험의 가속 진행을 위하여 치면 및 구강에 가장 큰 영향을 미치는 당류인 설탕 4중량부, 조청(grain syrup) 6중량부, 및 그 외 함유 성분으로 연유, 마가린, 모노글리, 향이 함유된 10g의 연질 캐러멜(caramel)을 1일 4개를 4회로 나뉘어 급여하였으며, 그 중 3마리의 개에게 상기 실시예 5에 따른 놀이기구를 1일간 상기 조성물을 4회 주입하여 제공한 뒤 다음 제공시간 까지 놀게 하고, 또 그 중 3마리의 개에게 상기 실시예 6에 따른 놀이기구를 1일간 상기 조성물을 4회 주입하여 제공한 뒤 다음 제공시간 까지 놀게 하며, 또 그 중 3마리의 개에게 상기 실시예 7에 따른 놀이기구를 1일간 상기 조성물을 3회 주입하여 제공한 뒤 다음 제공시간 까지 놀게 하며, 또 그 중 3마리의 개에게 상기 실시예 8에 따른 놀이기구를 1일간 상기 조성물을 4회 주입하여 제공한 뒤 다음 제공시간 까지 놀게 하였다.Fifteen test animals were fed a certain amount of artificial feed for three months (12 weeks) while providing adequate exercise in the same space with comfortable light and ventilation, which had the greatest impact on dental and oral cavity for the accelerated progression of this study. 4 parts of 10g soft caramel containing condensed milk, margarine, monogly and fragrance as 4 parts by weight of sugar, 6 parts by weight of grain syrup, and other ingredients were divided into 4 times a day. In addition, three dogs were provided with the play equipment according to the fifth embodiment of the present invention by injecting the composition four times for one day, and then played until the next serving time, and three dogs of the dogs according to Example 6 Play equipment is provided by injecting the composition 4 times for 1 day and then played until the next providing time, and three dogs are provided with the composition of the play equipment according to Example 7 3 times per day Back and then provided to the play time, and further to play the three of which to the embodiment 8 in accordance with the play mechanism for one day after the composition provided by the fourth injection, and then providing the time.
아울러, 대조를 위하여 나머지 3마리의 개에게는 외부가 천으로 피복된 놀이기구를 제공하여 치아 및 구강 상태를 비교하였다. 그 결과를 하기 표 1에 나타내었다.In addition, for comparison, the remaining three dogs were provided with a cloth-coated ride to compare teeth and oral conditions. The results are shown in Table 1 below.
<검사 및 평가방법><Inspection and Evaluation Method>
평가방법은 치아우식 활성검사법의 1)치면착색제 검사법(disclosing solution or tablet)과 2)구강내 산생성균 검사(modified snyder test by use of cariostat)법, 3)기호성 평가, 4)사용성 평가를 위한 놀이기구의 상태 관찰을 시행하였으며 그 평가법은 다음과 같이 하였다.Evaluation methods were 1) disclosing solution or tablet of dental caries activity test, 2) modified snyder test by use of cariostat method, 3) palatability evaluation, and 4) playability evaluation. Observation of the condition of the instrument was conducted and the evaluation method was as follows.
#평가법 1#Evaluation method 1
치면착색제 검사법(disclosing solution or tablet)Disclosing solution or tablet
치면착색제(disclosing agent)를 이용해 실시예에 따른 시험동물의 치아에 2주에 1회씩 6회(3개월)에 걸처 착색하여 치면에 존재하는 치면세균막의 유무 및 위치를 파악하고 착색된 결과를 치면세균막 지수(PHP index) 측정방법에 따라 비교 평가하였다.The tooth of the test animal according to the embodiment was stained every six weeks (three months) every two weeks using the disclosing agent to determine the presence and location of the bacterial bacterial membrane on the tooth surface and the colored result Comparative evaluation was performed according to the method of measuring the bacterial membrane index (PHP index).
#평가법 2#Evaluation 2
구강내 산생성균 검사(modified snyder test by use of cariostat)Modified snyder test by use of cariostat
본 검사는 일반적으로 구강내 산생성균의 양과 활동성을 알아보는 검사법으로 치면세균막이나 타액속에 포함된 세균이 산(acid)을 형성한다는데에 근거를 두고 타액내에 있는 산생성균의 활성 정도를 비색법을 측정하였다. 그 검사방법으로는 시험동물의 치아를 2주에 1회씩 6회(3개월)를 상하악 구치부 협면쪽의 치면을 문질러 치면세균막을 채취하고 채취한 면구를 준비된 배지속에 넣고 마개를 닫은후 배지를 배양기속에서 37℃에서 48시간을 배양하여 배지의 색깔변화를 비교 판정하였다.This test is a test to determine the amount and activity of acid-producing bacteria in the oral cavity. It is a colorimetric method that measures the activity of acid-producing bacteria in saliva based on the formation of acid in bacteria or saliva. It was. As a test method, the teeth of the test animal were rubbed 6 times (3 months) once every two weeks by rubbing the tooth surface of the upper and lower posterior buccal surface. After collecting the bacterial membrane, the collected cotton ball was put in the prepared medium and the stopper was closed. 48 hours of incubation at 37 ° C. in the incubator were compared to determine the color change of the medium.
#평가법 3#Evaluation 3
기호성 평가의 관찰Observation of palatability evaluation
시험동물의 본 조성물에 대한 기호도를 관찰하는 방법으로 상기 조성물을 반복투여를 통하여 각 실시예별로 그 친숙성을 관찰하였다. 구체적으로 각 실시예에 따라 조성물이 주입된 놀이기구를 각 시험동물들에게 던져 준 그 즉시 및 계속적으로 놀이기구를 씹음의 상태를 관찰하여 비교평가 하였다.The familiarity was observed for each example through repeated administration of the composition by a method of observing the preference of the present composition of the test animal. Specifically, the test equipment was thrown to each of the test animals injecting the composition injected according to each embodiment, and the evaluation was performed by observing the state of chewing the play equipment.
#평가법 4#Evaluation 4
사용성 평가를 위한 놀이기구 상태 관찰Observe ride status for usability assessment
시험동물의 본 조성물에 대한 사용성 평가를 위한 관찰 방법으로 각 실시예에 따른 동일한 놀이기구를 제공하되 시험 중 본 발명의 조성물을 주입하지 못할 정도로 헤어진 상태를 확인하여 교체 투입하고 시험 최종일까지 놀이기구의 교체한 수량을 통하여 사용성을 평가하는 방법으로 각 실시예에 따른 교체 투입한 놀이기구의 수량이 가장 많은 실시예를 사용성이 가장 양호한 실시예로 평가하였다.As an observation method for evaluating the usability of the present composition of the test animal, the same play equipment according to each embodiment was provided, but the separated state was not inserted to the extent that the composition of the present invention could not be injected during the test. As a method for evaluating the usability through the replacement quantity, the embodiment with the greatest number of replacement equipments put in and out of each example was evaluated as the best usability example.
상기 평가법에 따라 비교 평가한 결과를 평균하여 하기 표 1에 나타내었다.The results of comparative evaluation according to the above evaluation method are shown in Table 1 below on average.
1) 치면 세균막 지수 판정 기준은 다음과 같이 하였다.1) The criteria for judging the bacterial membrane index were as follows.
양호 0∼1, 보통 1∼2, 불량 2∼3 및 매우불량 3∼5 Good 0 ~ 1, Usually 1 ~ 2, Poor 2 ~ 3 and Very bad 3 ~ 5
2) 산생성균 판정기준은 하기 표 2와 같다.2) Acid producing bacteria determination criteria are shown in Table 2 below.
3) 기호성 판정기준은 하기 표 3과 같다.3) The palatability criteria is shown in Table 3 below.
상기 결과를 볼 때 실시예 5와 7의 경우는 본 조성물의 기호성 및 사용성이 다소 떨어지나 본 발명의 목적을 충분히 도달할 수 있었으며, 특히 실시예6 및 8의 경우는 애완동물이 좋아하는 냄새와 맛으로 인하여 기호성과 사용성이 높아 사용의 빈도수가 높아 지는만큼 결과의 우수함을 확인할 수 있었다.In the case of Examples 5 and 7, the palatability and usability of the composition were somewhat reduced, but the purpose of the present invention was sufficiently reached, and particularly in Examples 6 and 8, the smell and taste of pets were preferred. As a result, the palatability and usability were high, and thus the frequency of use was increased.
전술한 바와 같이, 본 발명의 조성물을 동물의 구강내 청결은 물론, 구강내 유해미생물, 치주염, 구취, 프라그(plaque)를 제거할 수 있는 효능이 있으며, 이를 본 발명에 따른 놀이기구에 주입하여 사용함으로써 동물의 치아 및 구강내 번식되는 유해미생물 및 치석, 충치, 구취를 없애주는데 더욱더 효과적이며, 상기 놀이기구의 구성 및 재질의 특성상 세척 및 세정이 용이하여 반영구적인 재사용이 가능하게 하여 비용절감 및 동물의 구강건강에 지속적인 효과를 제공할 수 있다.As described above, the composition of the present invention is effective in removing oral cleansing of animals, as well as removing harmful microorganisms, periodontitis, bad breath, and plaque in the oral cavity, and injecting the composition into the play equipment according to the present invention. It is more effective in eliminating harmful microorganisms and dental plaque, tooth decay, and bad breath, which are reproduced in the teeth and oral cavity of animals, and it is easy to wash and clean due to the structure and material of the play equipment. It can provide a lasting effect on the oral health of the animal.
도 1은 본 발명에 따른 애완동물의 구강 및 치아 보호용 액상조성물이 주입되는 애완동물용 놀이기구를 개략적으로 나타낸 사시도이다.1 is a perspective view schematically showing a pet play equipment to which the liquid composition for oral cavity and tooth protection of a pet according to the present invention is injected.
도 2는 도 1의 A-A선을 따라 절개한 면을 도시하는 단면도이다.FIG. 2 is a cross-sectional view illustrating a plane cut along the line A-A of FIG. 1.
* 도면의 주요부분에 대한 부호의 설명 *Explanation of symbols on main parts of drawing
1: 내부 충진물 2: 외피1: inner filling 2: outer shell
Claims (9)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003256095A AU2003256095A1 (en) | 2002-07-31 | 2003-07-30 | Liquid composition for protecting oral cavities and teeth of pet animals and use thereof in plaything for pet animals |
| PCT/KR2003/001539 WO2004010962A1 (en) | 2002-07-31 | 2003-07-30 | Liquid composition for protecting oral cavities and teeth of pet animals and use thereof in plaything for pet animals |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020020045452A KR20020070661A (en) | 2002-07-31 | 2002-07-31 | Animal toothbrush to be able to do toothbrushing by themselves. |
| KR1020020045452 | 2002-07-31 | ||
| KR1020020045451 | 2002-07-31 | ||
| KR1020020045451A KR20020068486A (en) | 2002-07-31 | 2002-07-31 | The edible toothpaste for animals. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20040012449A KR20040012449A (en) | 2004-02-11 |
| KR100513117B1 true KR100513117B1 (en) | 2005-09-07 |
Family
ID=37320408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2003-0027292A KR100513117B1 (en) | 2002-07-31 | 2003-04-29 | Toy for protecting an oral cavity and a teeth of a pet animal |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR100513117B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220147465A (en) * | 2021-04-27 | 2022-11-03 | 김대용 | Toy toothbrush for pets |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009212341A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care toothbrush |
| AR070357A1 (en) * | 2008-02-08 | 2010-03-31 | Colgate Palmolive Co | PRODUCT FOR ORAL CARE AND METHODS OF USE AND MANUFACTURE OF THE SAME |
| KR101016366B1 (en) * | 2008-06-20 | 2011-02-21 | 금호타이어 주식회사 | Pneumatic tire |
| KR101473154B1 (en) * | 2014-05-30 | 2014-12-15 | 김충균 | Masticatory Masses For Oral Hygiene |
| CN105919829B (en) * | 2016-06-29 | 2018-11-09 | 贵州扬生医用器材有限公司 | A kind of mouthwash and preparation method thereof |
| KR102247672B1 (en) * | 2019-02-28 | 2021-05-11 | 양정민 | Companion animal dental functional play |
| KR102375789B1 (en) * | 2019-10-24 | 2022-03-17 | 최우수 | clean device for pet teeth |
| DE102020000733A1 (en) * | 2020-02-04 | 2021-08-05 | Dr. Kurt Wolff Gmbh & Co. Kg | Oral care composition for animals |
| KR102386108B1 (en) * | 2021-07-28 | 2022-04-14 | 전남대학교산학협력단 | Abrasive composition for pet snack and pet snack composition comprising the same |
-
2003
- 2003-04-29 KR KR10-2003-0027292A patent/KR100513117B1/en not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220147465A (en) * | 2021-04-27 | 2022-11-03 | 김대용 | Toy toothbrush for pets |
| KR102637682B1 (en) | 2021-04-27 | 2024-02-15 | 김대용 | Toy toothbrush for pets |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040012449A (en) | 2004-02-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4444925B2 (en) | Anti-plaque oral composition | |
| US8435499B2 (en) | Toothpowder composition containing wheat flour and bamboo salt | |
| CN101321537A (en) | Confectionary compositions with magnolia bark extract | |
| CN106963662B (en) | Color-changing toothpaste for children and preparation method and application thereof | |
| US20090269288A1 (en) | Black pearl toothpaste | |
| CN101321560A (en) | Chewable compositions with fast release magnolia bark extract | |
| KR100513117B1 (en) | Toy for protecting an oral cavity and a teeth of a pet animal | |
| RU2573987C2 (en) | Method and composition (versions) for reduction of quantity of volatile sulphur-containing compounds in oral cavity | |
| GB1599748A (en) | Compositions containing saccharose-inverting enzyme | |
| US6231836B1 (en) | Folic acid dentifrice | |
| CA2478585A1 (en) | A chewable toy for animals | |
| KR20140023081A (en) | Toothpaste composition containing stone cell and toothpaste prepared therefrom | |
| CN108524418A (en) | A kind of natural antiscale whitening toothpaste and preparation method thereof | |
| KR20200074569A (en) | Dental functional natural gel composition for companion animal and Dental functional silicone material play equipment | |
| US11723847B2 (en) | Dual component oral composition for enhancing remineralization of teeth | |
| KR101660467B1 (en) | Oral composition containing fermentative extract of lycii fructus as active ingredient | |
| CA2188387C (en) | Hard candy with tooth plaque-neutralizing effect | |
| WO2004010962A1 (en) | Liquid composition for protecting oral cavities and teeth of pet animals and use thereof in plaything for pet animals | |
| FR2822700A1 (en) | Ingestible buccal hygiene compositions, useful for human or animal use. comprise a gel that adheres to the teeth and gums and releases active materials over a prolonged period | |
| CN110538089B (en) | Antibacterial halitosis-removing pet toothpaste | |
| KR102622833B1 (en) | Powder-type oral cleaner comprising hydroxy apatite | |
| Aravinth et al. | Role of chewing gum in oral hygiene maintenance. | |
| DE10258659B4 (en) | Use of Salvadora persica in oral and dental care for pets and pets | |
| CN102068704B (en) | Dental plaque detection liquid | |
| KR20210027956A (en) | Toothpaste composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20110901 Year of fee payment: 7 |
|
| LAPS | Lapse due to unpaid annual fee |