KR20200132025A - Toothpaste material containing skin nano meal of paper mulberry and method for manufacturing of the same - Google Patents

Abstract

The present invention relates to a toothpaste composition containing Broussonetia kazinoki bark nanoparticles. According to several embodiments of the present invention, the toothpaste composition containing Broussonetia kazinoki bark nanoparticles as an abrasive solves problems of expensive cost, or enamel or dentin abrasion, which may occur when chemical components or walnut shell powders are used as conventional abrasives. The present invention also has the advantage of being able to adjust the degree of polishing according to the size of the Broussonetia kazinoki bark nanoparticles, and improving the stability and feeling of use as a natural product. In addition, a method of pulverizing Broussonetia kazinoki bark into nanoparticle powders can be performed inexpensively by presenting a method of pulverizing the Broussonetia kazinoki bark through rapid freezing, crushing the same with an air jet mill, or pulverizing the same with a colloid mill, and eco-friendly materials with proven antibacterial effects can be applied to a toothpaste composition, a daily necessity.

Description

Toothpaste composition and method for manufacturing the same containing paper mulberry bark nanoparticles {TOOTHPASTE MATERIAL CONTAINING SKIN NANO MEAL OF PAPER MULBERRY AND METHOD FOR MANUFACTURING OF THE SAME}

The present invention relates to a toothpaste composition comprising oak bark nanoparticles and a method for manufacturing the same, characterized in that it contains 0.01 to 5% by weight of finely pulverized oak bark nanoparticles in a paste-like toothpaste based on the total composition. The role of an abrasive that removes food debris attached to the surface, and plaque removal, periodontitis and gingivitis prevention, gum disease prevention, calculus plaque removal, tooth decay prevention, oral freshness, bad breath removal, antibacterial effect proven and high stability It relates to a toothpaste composition containing and a method of manufacturing the same.

In general, dental diseases and gum diseases are caused by neglect of tooth cleaning after eating food. Therefore, cleaning teeth within a certain period of time after eating food is the most important for maintaining healthy teeth and gums. Yet, it is a basic element, and for tooth cleaning, anyone brushes with toothpaste.

Toothpaste is a type of tooth cleaner to remove food debris and bacterial membranes attached to the teeth. Its main purpose is to refresh the mouth and remove bad breath. It delivers effective ingredients to prevent tooth decay to prevent tooth decay or include whitening ingredients. It also whitens. There are low viscosity liquid type, high viscosity paste type, and powder type for toothpaste, but mainly paste type is preferred, and is packaged in a tube container and squeezed to be used.

Toothpaste is an abrasive that physically removes debris attached to the teeth, a surfactant that helps to effectively remove the debris attached to the teeth, water to have an appropriate viscosity and an excipient that helps to maintain the shape, and prevents it from hardening. Moisturizing agent is the main ingredient, and it is composed of additives such as flavoring, sweetener, preservative, and coloring to suit the taste of consumers.These toothpastes are effective in removing calculus, esthetic effect, whitening function, tooth decay prevention, bad breath, and gingivitis prevention. And is classified as general medicine.

The role of the toothpaste abrasive is to physically remove debris from the tooth surface, but can also wear the enamel or dentin of the tooth, so the abrasion of the abrasive is important.It is to wipe the surface of the tooth clean or if plaque easily occurs. User convenience by developing toothpaste that can be widely applied to children and adolescents, as well as adults with a lot of plaque and tartar, without the need to separate and use toothpastes with different abrasion levels depending on the purpose, such as toothpaste with high wear and low toothpaste in case of aching. Need to improve.

Typical abrasives commonly applied include calcium hydrogen phosphate, precipitated calcium carbonate, silica, and insoluble sodium metaphosphate.These abrasives have a higher hardness than carbonate apatite, a component of tooth enamel, and the enamel of the tooth wears out when cleaning is performed. As a result, the teeth become weak, and in the area where the enamel at the boundary of the gum is thin, the dentin is exposed, so that the gums become aching and severe pain can be felt. In addition, since the currently used abrasives have an average particle diameter of 10-30 µm, for effective polishing, the amount of addition of 40% or more must be high and the brushing time must be increased.

On the other hand, in order to solve the above problems, a lot of development of toothpaste compositions containing natural products has been made.As a composition for oral cavity such as toothpaste developed in the past, KR10-2010-003429 is described in KR10-2010-003429. , A composition for oral cavity, which is effective in removing plaque and preventing gum disease by including plant extracts such as horseback riding extract and myrrh extract, is disclosed, but in the case of walnut shell powder particles, the surface is very rough, so that the texture of the teeth may be worn. , Since most of the walnut shell powder is imported, there is a problem that high cost occurs when used for polishing purposes.

In addition, in KR10-2004-0054317, a toothpaste composition containing a vegetable abrasive coated by lyophilizing components including fibers of leaves, stems, and fruit peels of plants, followed by pulverization, is added to a starch solution or polymer. Although disclosed, there is a problem in that the polishing effect cannot be greatly improved with the vegetable polishing agent alone, and thus an abrasive composed of chemical components such as silica, potassium carbonate, sodium chloride, calcium monohydrogen phosphate, alumina, and the like must be included.

In addition, the green tea toothpaste composition disclosed in KR10-2005-0082688 and the toothpaste composition including the loess and pine needle extract disclosed in KR10-2006-0092508 have been developed, but as discussed above, toothpaste compositions containing natural products also have problems to be solved. However, there is a need to develop a toothpaste abrasive that can be widely applied not only to normal people, but also to children and adolescents with weak tooth tissues, and patients with severe tooth wear.

Typically, a paste-like toothpaste is prepared by mixing an abrasive for removing tartar, a viscosity modifier and a foaming agent, a sweetener, a periodontal disease preventer, a humectant, a preservative, a flavoring agent, etc. to maintain the shape of the toothpaste as a paste.

Korean Patent Registration No. 10-0877981 discloses a toothpaste composition for whitening teeth in a paste form.

The toothpaste composition uses silica as an abrasive, and as a foaming agent, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene (hardened) castor oil, glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, alkylolamide, alkyl glucoside Nonionic surfactants such as, and cationic surfactants such as N-alkyldiamino ethylglycine are used.

As described above, conventionally, in the case of paste toothpaste, an abrasive material such as silica or calcium carbonate is always added, which has a problem of damaging tooth enamel by brushing.

In addition, since food uses a chemical surfactant as a foaming agent to remove debris or oil, there is a problem that causes anxiety to consumers due to oral cell irritation and toxicity.

Liquid toothpaste has been disclosed as a supplementary toothpaste, but it is less effective than pasty toothpaste in removing food waste, and surfactants also adopt milder ingredients, but this also fails to meet consumer expectations.

Meanwhile, more than 400 kinds of bacteria are breeding in the mouth of a person, and the number of bacteria reaches 10 billion. In addition, bacteria at a level of 108 to 109 CFU/ml are detected in saliva.

The teeth are perforated with a number of microscopic holes, so bacteria that cause tooth decay enter the aforementioned holes and make the teeth sick. This is caries. These cavities are one of the most common diseases that can be seen in teeth and are also called dental caries. It is an infectious bacterial disease in which food in the mouth is decayed by acid-resistant streptococcus and lactic acid bacteria, and the components of teeth are destroyed by acid.

In Korea, the caries morbidity rate of permanent teeth reaches about 80%, and it is reported that one person has an average of 2-3 cavities.

It is known that various causes of tooth decay are working in combination, but the most important thing is plaque. Plaque contains several bacteria, especially acid-resistant streptococcus and lactobacilli, among which Streptococcus mutans is known as a major caries bacteria. As such Streptococcus mutans attaches to the surface of the tooth and grows, it uses sugar in the food to generate acid to corrode the teeth and at the same time invade the bone cells of the teeth to cause various alveolar bone erosion and gum disease. In detail, the first step is the process of the formation of plaque on the tooth surface by the caries causative bacteria, and the second step is the process of generating organic acids in the plaque, and by organic acids and proteolytic enzymes generated in the plaque. It consists of a third step that demineralizes the inorganic substances constituting the tooth surface and further dissolves the organic substances. In addition, in the case of periodontal disease, plaque attached to the tooth surface and periodontal tissue is the main cause of the occurrence and progression of periodontal disease. As a result, harmful metabolites or bacterial enzymes are produced by bacteria in the plaque, resulting in gingivitis. And is known to progress.

Bad breath refers to the smell originated from the oral cavity and adjacent organs, and many people complain of discomfort in everyday life due to bad breath. 85-90% of bad breath comes from the oral cavity, especially from the back of the tongue. The main components of bad breath are volatile sulfur compounds, and 90% of the total amount of volatile sulfur compounds is hydrogen sulfide made from cysteine and methyl mercaptan and dimethyl sulfide made from methionine. These components are mainly produced by protein enzymes secreted by anaerobic bacteria, and the back of the tongue is the most important habitat. This area is not well cleaned by saliva, and there are many small depressions, making it a place where bacteria continue to live. The generation of volatile sulfur compounds by anaerobic bacteria is the most important cause of bad breath, but it is also caused by oral diseases such as tooth decay and periodontitis. Although many types of anaerobic bacteria are involved in generating bad breath, in particular, representative bacteria of bad breath are Porphyromonas gingivalis and Prevotella intermedia, which secrete many types and large amounts of enzymes. ), Fusobacterium nucleatum, Bacteoides forsythus, Treponema deticola, etc., and is also known as a representative causative agent of periodontitis. In order to suppress bad breath, it is most effective to suppress the proliferation of anaerobic bacteria that produce volatile sulfur compounds, which are the main components of bad breath, so conventionally, a tongue scraper is used to remove the growth substrate of bacteria from the tongue. Metal salts such as zinc chloride or disinfectants such as alcohol or chlorhexidine were used to remove or inhibit the growth of anaerobic bacteria or the formation of volatile sulfur compounds by anaerobic bacteria. However, these metal salts and disinfectants inhibit the development of not only anaerobic bacteria that cause bad breath, but also other microorganisms in the oral cavity.Because these substances are not swallowed into the esophagus, they do not go to the back of the tongue, which is an important place for the occurrence of bad breath, and are mainly located in the front of the mouth. Gargled and spit out of the mouth. Therefore, there is a problem that it cannot be disinfected to the back of the tongue, which is the main proliferation site of anaerobic bacteria that cause bad breath. In addition, these substances are diluted with saliva and swallowed with saliva into the esophagus, so that the effect in the oral cavity is only about 20 minutes to 2 hours, after which microorganisms proliferate again in the oral cavity, resulting in bad breath. Therefore, metal salts or disinfectants used to reduce bad breath have only a short period of effect, and recurrence of bad breath is frequent.

Recently, attempts have been made to suppress the proliferation of anaerobic bacteria using lactic acid bacteria (Korean Patent Registration No. 10-1062779, etc.), but when these lactic acid bacteria are administered to the oral cavity, they are diluted with saliva like metal salts or disinfectants, and then directly into the esophagus. It is difficult to remain in the mouth due to being swallowed. In addition, since the acid component of lactic acid bacteria causes tooth decay, there is a problem that it is not good for oral hygiene if administered to the oral cavity for a long time.

In addition, in recent years, periodontal disease is not only a chronic infection of the gingival tissue, but is attracting attention as a risk factor such as myocardial infarction, arteriosclerosis, diabetes, and premature birth. Therefore, the use of toothpaste may imply the possibility of becoming the basis for improving various health conditions. On the other hand, in general, 0.05 to 0.1 for toothpaste or mouthwash to prevent tooth decay or periodontitis. Fluoride at a concentration of w/v% is often used. According to recent reports, the use of fluoride compounds in toothpastes and mouthwashes can prevent dental caries, but long-term and repeated use of fluoride compounds promotes inflammation in the gums. It turns out to be. Therefore, there is a need for a toothpaste composition capable of suppressing aching teeth and preventing dental caries without using fluoride.

The problem to be solved by the present invention is to use the finely pulverized oak bark nanoparticles containing 0.01 to 5% by weight of the total composition of the sesame strong calcium carbonate or walnut bark powder used as an abrasive for toothpaste. A toothpaste composition that has an antibacterial effect, removing plaque, preventing periodontitis and gingivitis, preventing gum disease, removing tartar plaque, preventing tooth decay, oral freshness, bad breath removal, and antibacterial effects using the role of an abrasive and the effectiveness of the oak tree that has been verified through various papers. Is to provide.

However, when the necessary particles are extracted and used from the oak tree, the role of an abrasive and the removal of plaque, periodontitis and gingivitis prevention, gum disease prevention, plaque removal, tooth decay prevention, oral freshness, bad breath removal, and antibacterial effect appear good, but very tough oak bark There was a problem in that it was very difficult to obtain finely pulverized oak bark nanoparticles having a size of 1 to 20 μm to obtain the above effect.

One aspect of the present invention is a toothpaste containing 0.01 to 5% by weight of finely pulverized oak bark nanoparticles based on the total toothpaste composition and uniformly dispersed and mixed; And a plurality of powdered oak bark nanoparticles made in the form of nanoparticle powders having a size of 500 to 1,000 mesh by crushing the oak bark, and being evenly dispersed and mixed in the toothpaste. It provides a toothpaste composition containing the oak bark nanoparticles, characterized in that it comprises a.

Another aspect of the invention, the first step of cutting the bark of the oak tree into a plurality of pieces; A second step of humidifying the pieces of oak bark to a moisture content of 5 to 30%; A third step of freezing the pieces of the oak bark with the moisture content adjusted in the form of ice by rapid nitrogen cooling at -200 to -250°C; A fourth step of pulverizing the pieces of ice-shaped oak bark and finely powdering them into nanoparticles having a size of 500 to 1,000 mesh; A fifth step of preparing a finished toothpaste by mixing the toothpaste composition and the plurality of powdered oak bark nanoparticles; It provides a method for producing a toothpaste composition containing the oak bark nanoparticles comprising a.

According to a preferred feature of the present invention, the fifth step may include 0.01 to 5% by weight of the powdered oak bark nanoparticles based on the total weight of the toothpaste composition.

Another aspect of the invention, the first step of cutting the bark of the oak tree into a plurality of pieces; A second step of finely powdering the pieces of the oak bark into nano-particle powders having a size of 500 to 1,000 mesh by spraying high-pressure air of about 250 atm in an air jet mill; A third step of preparing a finished toothpaste by mixing the toothpaste composition and the plurality of powdered oak bark nanoparticles; It provides a method for producing a toothpaste composition containing the oak bark nanoparticles comprising a.

Another aspect of the invention, the first step of cutting the bark of the oak tree into a plurality of pieces; The oak bark pieces are pulverized into nano-scale particle powder between a plate and a fixed plate rotating at a high speed of 1,000 to 20,000 rpm in a colloid mill, and finely powdered into a nano-particle powder having a size of 500 to 1,000 mesh. The second step; A third step of preparing a finished toothpaste by mixing the toothpaste composition and the plurality of powdered oak bark nanoparticles; It provides a method for producing a toothpaste composition containing the oak bark nanoparticles comprising a.

According to a preferred feature of the present invention, after the first step, the step of steaming a piece of oak bark and washing it with steam, and then peeling the black skin to extract the white skin after steaming; And washing the white skin. You can proceed further in order.

The present invention relates to a toothpaste composition containing finely pulverized oak bark nanoparticles, wherein the composition containing finely pulverized oak bark nanoparticles has excellent antibacterial effects against bacteria that cause tooth decay, periodontitis or bad breath. Accordingly, the composition containing the finely pulverized oak bark nanoparticles can be easily used not only as a toothpaste, but also as a pharmaceutical composition for the prevention or treatment of tooth decay or periodontitis, a health functional food for the prevention or improvement of tooth decay, periodontitis or bad breath. have.

In addition, the toothpaste composition containing finely pulverized oak bark nanoparticles as an abrasive can solve the problem of high cost or abrasion to enamel or dentin when using chemical components or walnut shell powder as a conventional abrasive, and the above It has the advantage of being able to adjust the degree of polishing according to the size of the oak bark nanoparticles, and it is a natural natural product that can improve the living environment with stability inside the oral cavity and eco-friendly materials.

Hereinafter, various aspects and various embodiments of the present invention will be described in more detail.

In this specification, the term'toothpaste' refers to a powder, cream, or liquid quasi-drug that is used as an auxiliary when brushing teeth, as a preparation for the purpose of whitening and strengthening teeth, cleansing the mouth, preventing teeth, gums and oral diseases, etc. it means. The main components of a typical toothpaste include an abrasive that grinds and polishes the tooth surface, a wetting agent that prevents the toothpaste from solidifying, and a detergent such as soap that removes dirt.

Black oak is an eco-friendly material that does not contain toxic components such as formaldehyde, which irritates the respiratory tract and causes lung water and rhinitis, as a material that causes skin cancer and sick house syndrome, as well as the above harmful substances. It has a harmless advantage to infants and the elderly who lack immunity to the material. The win-win relationship between the oak tree and humans has been used as an important element in daily necessities, foods, and medicines since the ancient times as it is recorded in long literature.

According to an aspect of the present invention, in a toothpaste composition comprising an abrasive and a cleaning agent, the composition containing finely pulverized oak bark nanoparticles is a toothpaste comprising 1 to 20 μm sized oak bark nanoparticles The composition is disclosed.

According to an exemplary embodiment of the present invention, the toothpaste abrasive containing the oak bark nanoparticles of the present invention is a natural abrasive, which is harmless to the human body, has excellent stability, and has very excellent polishing effects such as plaque and tartar removal. In addition, the oak bark nanoparticles of the present invention have excellent moisture absorption and, on the other hand, insoluble in water, so that the conventional toothpaste abrasive component can be diluted when it comes into contact with water to solve the problem that the abrasive effect is inferior. It can be usefully used as a composition.

In one embodiment of the present invention, the oak bark nanoparticles are characterized in that it comprises 0.01 to 5% by weight based on the total weight of the composition.

When the amount of the oak bark nanoparticles is less than 0.01% by weight, there may be a problem in that the polishing efficiency is deteriorated, and when it is added in an amount exceeding 5% by weight, there may be a problem that the tooth surface is excessively polished.

On the other hand, containing the oak bark nanoparticles added to the toothpaste composition in an amount of 0.01 to 5% by weight, and the toothpaste composition is characterized in that the toothpaste composition is pulverized to about 500-1000 mesh.

If the particle size is less than 500 mesh, there may be a problem that a foreign body sensation occurs in the mouth when brushing teeth due to large particles as a toothpaste, and if it exceeds 1000 mesh, the efficacy as an abrasive may be reduced.

In the toothpaste composition, conventional surfactants may be used as cleaning agents. These cleaners prevent foreign substances separated from the tooth surface from sticking to the tooth surface when brushing teeth, and have a function of completely discharging them to the outside of the oral cavity when brushing.These cleaners include alkyl sulfates, olefin sulfonates, monoglyceride sulfonates, etc. Anionic surfactants and nonionic surfactants such as reoxyethylene sorbitan fatty acid ester, polyoxyethylene castor oil, glycerin fatty acid ester, alkylolamide, etc., and amphoteric surfactants such as Pluronic F-108 may be selected. It can also be purchased and used commercially.

All of these detergents are listed by way of example, and in addition to these, various detergents having surface activity may also be used in the present invention. In addition, in addition to the abrasive and other active ingredients, there is an excipient as used for increasing or forming a paste, which means'orally acceptable carrier', which can be easily purchased and used by those skilled in the art.

The toothpaste composition may further contain a toothpaste preventing component comprising xylitol, a fluorine compound, or a mixture of two or more of them in an amount of 0.1 to 5% by weight based on the total weight of the toothpaste composition. The xylitol is obtained from a natural substance such as birch extract, and it is known to be effective in preventing tooth decay by inhibiting the growth of bacteria and having a sweet taste without containing sugar. The xylitol can also be used as a sweetener. Fluorine compounds have also been known to be effective in preventing tooth decay from a long time ago, and those skilled in the art are known enough to easily purchase and use them. If the toothpaste prevention component is contained in an amount of less than 0.1% by weight based on the total weight of the toothpaste composition, it becomes difficult to expect a dental caries prevention effect, and when it exceeds 5% by weight, the content of other ingredients is reduced. There may be.

In addition, in order to prevent periodontal disease, water-soluble salts such as sodium bicarbonate or sodium bicarbonate having a high osmotic pressure, aminocaproic acid, allantoin and allantoin derivatives having hemostatic action, and various vitamins can be used at the same time.

The toothpaste composition may further contain auxiliary ingredients consisting of other wetting agents, binders, foaming agents, sweetening agents, flavoring agents, coloring agents, or a mixture of two or more thereof in an amount of 0.1 to 50% by weight based on the total weight of the toothpaste composition.

These humectants, foaming agents, sweetening agents, flavoring agents, and coloring agents are also those that are known to those of ordinary skill in the art of manufacturing toothpaste to be readily available to purchase and use them. In addition, titanium dioxide or the like may be used to improve whitening. When the auxiliary ingredients are included in an amount of less than 0.1% by weight based on the total weight of the toothpaste composition, there may be a problem in that it is difficult to form an appropriate toothpaste by these auxiliary ingredients. There may be a problem causing insufficient content of ingredients.

The humectant included in the toothpaste composition of the present invention is an essential base component for making a toothpaste formulation.It prevents drying and solidification when the toothpaste is exposed to air, provides shine to the surface of the toothpaste, and has a sweetening effect when brushing teeth depending on the type. Plays a role in giving. In the toothpaste composition of the present invention, at least one selected from concentrated glycerin (98%), glycerin (85%), sorbitol aqueous solution (70%), amorphous sorbitol aqueous solution (70%), polyethylene glycols and propylene glycol is selected and used. I can.

The binder serves to prevent the solid powder component and the liquid component from being separated. Any kind of water-soluble polymer can be used, and commonly used components include sodium carboxymethylcellulose synthesized from cellulose of wood, carrageenan extracted from seaweed, and xanthan gum obtained from the metabolism of microorganisms. have.

The foaming agent improves the feeling of use of the product, helps the cleaning action, accelerates the dispersion and penetration of other medicinal ingredients, and reduces the interfacial tension, thereby making foreign substances in the oral cavity easily fall off. As the foaming agent, mainly anionic surfactant sodium lauryl sulfate, polyoxyethylene-polyoxypropylene copolymer (poloxamer), polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and the like can be used.

In addition to the above ingredients, flavorings, sweeteners, and pigments may be used in order to improve the feeling of use, and the use of edible edible flavors is essential as the flavoring used for this purpose. Sodium saccharin and stevioside are used as sweeteners, and food coloring is preferably used as the coloring matter.

In order to construct the toothpaste composition as described above, first, the oak bark is finely pulverized to a size of 1 to 20 μm to obtain the oak bark nanoparticles. As a pulverizing method, it can be finely crushed using a quick-freeze crushing, a colloid mill or an air jet mill. The quick-freezing crushing method includes a first step of cutting the oak bark into a plurality of pieces; A second step of humidifying the pieces of oak bark to a moisture content of 5 to 30%; A third step of freezing the pieces of the oak bark with the moisture content adjusted in the form of ice by rapid nitrogen cooling at -200 to -250°C; A fourth step of pulverizing the pieces of oak bark in the form of ice and finely powdering them into nanoparticle powders having a size of 500 to 1,000 mesh; A fifth step of preparing a finished toothpaste by mixing the toothpaste composition and the plurality of powdered oak bark nanoparticles; It characterized in that it comprises a. At this time, if the cooling temperature is lower than -250℃, an excessive cost may be incurred in the work process compared to the efficiency, and if the cooling temperature is higher than -200℃, some of the pieces of oak bark are not completely cooled in the form of ice. Problems can arise.

Another aspect is a first step of cutting the bark of the oak tree into a plurality of pieces; A second step of finely powdering the pieces of the oak bark into nano-particle powders having a size of 500 to 1,000 mesh by spraying high-pressure air of about 250 atm in an air jet mill; A third step of preparing a finished toothpaste by mixing the toothpaste composition and the plurality of powdered oak bark nanoparticles; It characterized in that it comprises a.

Another aspect of the invention, the first step of cutting the bark of the oak tree into a plurality of pieces; The oak bark pieces are pulverized into nano-scale particle powder between a plate and a fixed plate rotating at a high speed of 1,000 to 20,000 rpm in a colloid mill, and finely powdered into a nano-particle powder having a size of 500 to 1,000 mesh. The second step; A third step of preparing a finished toothpaste by mixing the toothpaste composition and the plurality of powdered oak bark nanoparticles; It characterized in that it comprises a.

The oak bark nanoparticles produced by the above method are added to a stirrer together with other materials, followed by primary stirring.

After adding to the stirrer, the mixture is stirred evenly for 10 to 30 minutes so that the oak bark nanoparticles and other compositions are uniformly mixed.

After the first stirring, the mixture inside the stirrer is heated and the temperature is raised to 35 to 45°C, followed by second stirring. Heating within this temperature range promotes mixing of the materials. If it exceeds 45℃, the rancidity of the materials rapidly accelerates, so it is desirable to keep the temperature below 45℃ during the secondary stirring. The second stirring time is preferably 40 to 80 minutes. If the stirring time is less than 40 minutes, it is difficult to uniformly mix the raw materials, and if the stirring time exceeds 80 minutes, heat is generated and there is a concern about deterioration of the raw materials.

After the second stirring, the mixture is degassed under vacuum. By removing air bubbles generated during the stirring process, it prevents deterioration by microorganisms.

To this end, the mixture was added to a paddle mixer and vacuum degassed under conditions of a pressure of 720 mmHg, a temperature of 40° C., and a time of 60 minutes while stirring at a speed of 100 rpm.

After degassing with vacuum, the prepared toothpaste composition is cooled at room temperature (20 to 30°C) and then stored at room temperature for about a day to stabilize. The stabilized toothpaste composition is filled into packaging containers such as tubes after inspection.

On the other hand, the present invention can be carried out by adding an agent for preventing periodontal disease, an agent for preventing tartar deposition, an agent for preventing bleeding from gums, an agent for preventing bad breath, a preservative, and a flavoring agent in the stirrer during the first stirring process.

The present invention is not limited by the above-described embodiments and the accompanying drawings. Therefore, various types of substitutions, modifications and changes will be possible by those of ordinary skill in the art within the scope not departing from the technical spirit of the present invention described in the claims, and this also belongs to the scope of the present invention something to do.

Claims (6)

A toothpaste composition containing a part of finely pulverized oak bark nanoparticles with respect to the entire toothpaste composition and uniformly dispersed and mixed; And a plurality of powdered oak bark nanoparticles made in the form of nanoparticle powders having a size of 500 to 1,000 mesh by crushing the oak bark, and being evenly dispersed and mixed in the toothpaste. A toothpaste composition and a method for producing the same, comprising the oak bark nanoparticles, characterized in that it contains. According to claim 1, Based on the total weight, the powdered oak bark nanoparticles 0.01 to 5% by weight of the toothpaste composition containing the oak bark nanoparticles, characterized in that it contains a method of manufacturing the same. The method of claim 1, further comprising: a first step of cutting the oak bark into a plurality of pieces by a method of manufacturing the oak bark into nanoparticle powder; A second step of humidifying the pieces of oak bark to a moisture content of 5 to 30%; A third step of freezing the pieces of the oak bark with the moisture content adjusted in the form of ice by rapid nitrogen cooling at -200 to -250°C; A fourth step of pulverizing the pieces of oak bark in the form of ice and finely powdering them into nanoparticle powders having a size of 500 to 1,000 mesh; A fifth step of preparing a finished toothpaste by mixing the toothpaste composition and the plurality of powdered oak bark nanoparticles; Toothpaste composition and a method for producing the same, comprising the oak bark nanoparticles comprising a. The method of claim 1, further comprising: a first step of cutting the oak bark into a plurality of pieces; A second step of finely powdering the pieces of the oak bark into nano-particle powders having a size of 500 to 1,000 mesh by spraying high-pressure air of about 250 atm in an air jet mill; A third step of preparing a finished toothpaste by mixing the toothpaste composition and the plurality of powdered oak bark nanoparticles; Toothpaste composition and a method for producing the same, comprising the oak bark nanoparticles comprising a. The method of claim 1, further comprising: a first step of cutting the oak bark into a plurality of pieces by a method of manufacturing the oak bark into nanoparticle powder; The oak bark pieces are pulverized into nano-scale particle powder between a plate and a fixed plate rotating at a high speed of 1,000 to 20,000 rpm in a colloid mill, and finely powdered into a nano-particle powder having a size of 500 to 1,000 mesh. The second step; A third step of preparing a finished toothpaste by mixing the toothpaste composition and the plurality of powdered oak bark nanoparticles; Toothpaste composition and a method for producing the same, comprising the oak bark nanoparticles comprising a. 6. The method of claim 3, 4 or 5, further comprising: after the first step, steaming a piece of oak bark with steam for washing, and then peeling the black skin to extract the white skin after steaming; And washing the white skin. Toothpaste composition and method for producing the same, characterized in that it can be further proceeded in order containing the oak bark nanoparticles.