KR20150076244A - 인간 시토메갈로바이러스 감염에 대한 재조합 입자 기재 백신 - Google Patents

Abstract

본 발명은 인간 시토메갈로바이러스 (HCMV) 및 기타 헤르페스 바이러스에 대한 예방용 또는 치료용 백신, 및 진단 및 R&D 도구로서 사용하기 위한, 바이러스-유사 입자 및 단백질 복합체 형태의 유전자 및 단백질 조립체에 관한 것이다. 상기 바이러스-유사 입자는 1종 이상의 헤르페스 바이러스 또는 레트로바이러스 유래 캡시드 단백질, 3종 이상의 CMV 표면 단백질, 및 임의로 외피 단백질을 포함한다. 조립체는 재조합 DNA를 일회용 세포 배양 및 정제 기술과 조합하는 기술을 사용하여 제조된다.

Description

인간 시토메갈로바이러스 감염에 대한 재조합 입자 기재 백신 {RECOMBINANT PARTICLE BASED VACCINES AGAINST HUMAN CYTOMEGALOVIRUS INFECTION}

본 발명은 캡시드 단백질, 시토메갈로바이러스 표면 단백질, 및 임의로 외피 단백질을 포함하는 바이러스-유사 입자, 및 인간 시토메갈로바이러스 감염에 대한 백신에 관한 것이다.

인간 시토메갈로바이러스 (HCMV)는 세계 모든 지역 및 모든 사회경제 군에서 발견되고 있다. 그것은 성인 군집의 60% 이상을 감염시키고 있으며; 일부 국가에서는 이미 100%의 풍토병 감염에 도달해 있다. 면역적격인 개체에서는 보통 감염이 무증상인데; 때로는 단핵구증-유사 질병이 발생할 수 있다. 감염은 예외없이 평생 잠복의 확립으로 이어지며, 거기에 가끔 재활성화가 개재될 수 있다. 치료적 또는 의원성 면역억제 이식/암 환자, 신생아 및 HIV 환자와 같은 면역결핍 개체는 HCMV 감염의 결과로써 상당한 이환율 및 사망률을 나타낸다.

CMV 감염의 현행 치료법은 간시클로비르 (발간시클로비르), 포스카르네트, 아시클로비르, 시도포비르 또는 레플루노미드와 같은 항바이러스 시약을 사용한 치료이다. 그와 같은 항바이러스제의 적용은 이식 수용자 및 면역손상 환자 (예컨대 HIV 환자)에 대해서는 승인되어 있으나, 임신한 여성에게는 그렇지 않다. 이러한 이유로, 고도이뮤노글로불린 치료법이 선호되고 있다. 또한, 기존의 항바이러스 치료법은 짧은 기간 이내에 바이러스 내성으로 이어지거나, 또는 치료 동안 효과적이지 않았었다 (문헌 [McGregor A. et al., Expert Opin. Drug Metab. Toxicol. 2011; 7(10):1245-1265]). 특히 선천성 감염에 대한 시토메갈로바이러스 감염의 예방이 오랜 시간 동안 조사된 바 있지만, 인가된 백신은 시장에 존재하지 않는다. 예방용 HCMV 백신의 개발은 미국 의약 연구소(Institute of Medicine) (www.cdc.gov/cmv/overview.html, October 2011)에서 최우선의 목표로 인식되고 있다. 선천성 감염 유아에서, 백신-유도 면역성의 잠재적 유익성은 자궁-내 전파와 관련하여서는 40-배, 중추 신경계 손상의 감소와 관련하여서는 25- 내지 30-배인 것으로 추정되고 있다 (문헌 [Britt W.J. et al., Trends Microbiol. 1996; 4:34-38]). 30년이 넘는 동안, 백신을 개발하기 위한 노력이 이루어져 왔다. 그러나, 어쩌면 부족하거나 불완전한 임상 연구 데이터로 인하여, 지금까지 인가에 임박한 것은 나타나지 않고 있다. 살아있는 약독화 바이러스 접근법은 물론, 가용성 단백질, 특히 MF59와 같은 아주반트와 조합되거나 조합되지 않은 감축된 gpUL55 (gB) 서브유닛 백신을 사용한 시도 역시 장기-지속성 면역 반응으로는 이어지지 않았다 (문헌 [Zhang C. et al., J. Clin. Virol 2006; 35:338-41]). 더 높은 효능을 달성하기 위한 새로운 접근법이 조사중에 있는데, 당단백질 조합, DNA 및 펩티드 기재 후보, 치밀 소체 (WO 2008/138590호) 및 바이러스 벡터 기재 후보, 예컨대 카나리폭스 바이러스를 기재로 하는 복제 가능 Alvac-gpUL555 (gB) 백신 (문헌 [Bernstein D.I. et al., J. Infect. Dis. 2002; 185:686-90])이 포함된다. 살아있는 약독화 바이러스와 조합된 Alvac 백신 (카나리폭스 기재 입자)을 사용한 첫 번째 임상 시험 데이터가 적절한 면역 반응으로 이어지기는 하였지만, 장기-지속 효과가 아직 조사중에 있다. 바이러스-유사 입자는 그의 형상으로 인하여 약독화된 바이러스와 유사한 특성을 제공하며, 그에 따라 백신 개발을 위한 가능성 있는 선택사항이 될 수 있는데, 특히 그것이 일반적으로 뛰어난 백신 비히클로 받아들여지고 있기 때문이다. 지금까지, CMV에 대해서는 바이러스-유사 입자가 개발되어 있지 않다. 항-HCMV 백신의 개발에 대하여 지난 30년 동안 수득된 경험으로 볼 때, 하기의 목표가 충족되어야 한다: 중화 항체의 장기-지속성 유도, 체액성 및 세포성, 특히 세포독성 T-세포 반응의 유도, 및 부작용의 최소화.

지금까지 개발된 백신 후보들의 실패 또는 제한된 효능의 이유는 다면적이다. 숙주에서의 보호 면역성의 메카니즘이 덜 밝혀져 있다. 이의 주요 이유 중 하나는 보호를 담당하는 이펙터를 확인할 수 있는 적절한 동물 모델의 부족이다. 상피 세포, 내피 세포, 평활근 세포, 섬유모세포, 뉴런 및 단핵구/대식세포를 포함한 다양한 세포 유형에 진입하여 거기에서 복제됨으로써 상이한 병리를 초래하는 바이러스의 능력은 강력한 이펙터의 확인을 방해한다. 바이러스의 복잡성, 및 특정 세포 유형의 감염에 필요한 단백질과 관련한 지식의 부족으로 인하여, 이상적인 HCMV 백신의 조성은 지금까지 불분명하다.

CMV는 베타-헤르페스바이러스로써, 매우 복잡한 바이러스 목인 헤르페스비랄레스(Herpesvirales)에 속한다. CMV 비리온은 직경이 ~230 nm로써, 뉴클레오캡시드로 구성되어 있으며, 덜 구조화된 외피 층으로 둘러싸여 있고, 삼층 멤브레인 외막에 의해 결합되어 있다. 선형의 이중-가닥 DNA 분자 (236 kbp)는 인간 헤르페스 바이러스 중 가장 커서, 헤르페스 심플렉스 바이러스 1 (HSV-1)의 것에 비해 50% 이상 더 크다. 비리온 이외에도, 5종의 다른 유형의 세포내 외막화 및 비-외막화 바이러스 입자가 CMV-감염 세포로부터 회수되고 있다. 바이러스 성숙 과정은 해당 치밀 소체 (DB)가 백신 개발에 있어서 중요한 역할을 할 수 있는 상이한 캡시드 유형들을 포함한다. 치밀 소체 (DB)는 크고 (~250-600 nm), 비균질성이다. 그것은 외피 단백질 (즉 pUL83), 및 표면 단백질 gpUL75 (gH) 및 gpUL55 (gB)를 포함하는 상이한 단백질들의 고체 구형 응집체이다 (문헌 [Becke S. et al., Vaccine 2010; 28:6191-6198]). 문헌 [Spaete R. et al., 1994, J. Gen. Virol., 75, 3287-3308]에 HCMV 단백질에 대한 일정한 명명법 규칙이 게재되어 있는데; 각 식별된 오픈 리딩 프레임 (ORF)의 문자숫자식 칭호가 기본이 되어, 단백질의 인산화 상태가 알려져 있지 않은 경우에는 접두어 "p"에 의해, 인단백질의 경우에는 "pp"에 의해, 그리고 당단백질의 경우에는 "gp"에 의해 연장된다. 단백질을 코딩하는 추가적인 ORF를 명명하는 데에는, 소문자 칭호가 접미어로 사용된다. 본 발명에서는, 이전에 사용되던 호칭들이 괄호 안에 표시되며, 표 및 도면에도 표시되어 있다.

HCMV 구조 당단백질들 중, 지금까지 3종의 주요 복합체들 (gCI-gCIII로 지칭됨)이 식별되어 있다. 이들 복합체는 바이러스 구조에서 상이한 역할을 하며, 그에 따라 백신 설계에 있어서의 치료용 항체의 개발을 위한 표적으로서, 또는 연구용 도구로서도 상이한 역할을 한다. 단일 가용성 단백질로서의 당단백질 B (gpUL55, gCI)는 HCMV에 대한 장기 지속성 면역 반응으로 이어지지 않았었다. 따라서, gpUL55를 포함한 추가적인 단백질 성분들이 백신 설계에 고려되어야 한다. 중화 항체 생성에 있어서의, 그리고 백신의 필수 구성요소로서의 gpUL100 (gM), gpUL73 (gN) 및 형성된 복합체 gCII의 역할은 조사중에 있다. gCIII의 구성요소는 이종삼량체인 디술피드-연결 복합체를 형성하는 gpUL75 (gH), gpUL115 (gL) 및 gpUL74 (gO)이다 (문헌 [Huber M.T. and Compton T., J. Virol. 1999; 73(5):3886-3892]). 이들 단백질은 gpUL128, gpUL130 및 gpUL131A와 같은 추가적인 단백질들과 함께 바이러스 진입 및 복합체 형성에 가장 중요한 역할을 한다. 상피 및 내피 세포로의 HCMV의 진입은 gpUL75, gpUL115 및 gpUL74, 또는 gpUL75, gpUL115, gpUL128, gpUL130 및 gpUL131의 조합의 세포내이입 및 복합체 형성과 연관되어 있다 (문헌 [Wang D. and Shenk T., PNAS 2005; 102:18153-18158]). 또한, 이들 단백질은 생체내 HCMV 전파의 주요 결정인자 역할을 하는 상피 세포로부터의 백혈구로의 HCMV의 전달을 담당한다. 또한, 이들 단백질은 수지상 세포 (DC)의 시동(priming)에서 역할을 하며, 그에 따라 T-세포 매개 면역 반응을 위한 중요한 요소인 것으로 보인다. CMV는 별개의 경로들에 의해 상이한 세포 유형에 진입한다. 섬유모세포 진입의 경우, gpUL75/gpUL115 (gH/gL) 또는 gpUL75/gpUL115/gpUL74 (gH/gL/gO) 포함 복합체를 필요로 한다. 이는 타운(Towne) 균주 또는 gpUL55 (gB) 아주반트 (MF59) 기재 백신을 사용한 예방접종 후 생성되는 중화 항체에 의해 차단될 수 있는 pH-의존성의 비-엔도솜 감염 경로이다 (문헌 [Pass R.F., J. Clin. Virol, 2009; 46 (Suppl. 4), S73-76]). 두 번째 중요한 경로는 오량체 복합체 gpUL75/gpUL115/gpUL128/gpUL130/gpUL131 (gH/gL/UL128/UL130/UL131A)을 필요로 하는 상피 및 내피 세포의 엔도솜 감염 과정이다. 이와 같은 감염 경로는 상기 오량체 복합체를 표적으로 하는 중화 항체에 의해 차단될 수 있다 (문헌 [Manley K. et al., Cell Host & Microbe 2011; 10:197-209]). 현재의 지식 상태에서 광범위한 세포성 및 체액성 면역 반응을 자극하는 효율적인 백신을 생성시키기 위해서는, 상기한 단백질들의 여러 조합을 필요로 한다. 그러나, 정확한 조합에 대해서는 알려져 있지 않다. 상기 오량체 복합체 단백질들의 중요성은 최근 문헌 [Lilleri D. et al., PLoS One, March 2013; 8(3): e59863, 1-13]에서 제기된 바 있다.

바이러스-유사 입자 (VLP)는 바이러스-유래 구조 항원들로부터 자가-조립되며 그에 따라 모체 바이러스와 유사한 구조적 특징 및 항원성을 가지는 안정하며 고도로 조직화된 구체이다. 살아있는 약독화 바이러스와 달리, 재조합 VLP는 안전하며, 비-감염성인데, 그것이 복제되는 바이러스 DNA를 포함하고 있지 않기 때문이다. 따라서, 그것은 생물안전성 레벨(biosafety level) 1하에 생성될 수 있다.

아데노바이러스, 레트로바이러스, 카나리폭스, 빅시니아 (폭스바이러스) 및 변형된 박시니아 바이러스 앙카라 (MVA) 벡터와 같은 몇 가지 상이한 바이러스 벡터들이 지금까지 백신으로서의 제약 개발을 위한 외래 항원을 발현하는 데에 사용되었었다 (문헌 [Wang Z. et al., J. of Virology 2004; 3965-3976]; [Jie Zhong et al., Plos One 2008; 3(9):e3256]). 상기 언급된 벡터들 대부분이 복제 가능한, 특히 레트로바이러스 기재 벡터이다 (문헌 [Dalba C. et al., Mol. Ther. 2007; 15(3):457-466]). 그러나, 재조합 VLP는 다른 백신 유형들이 가지고 있는 것과 같은 바이러스 복제 또는 불활성화와 연관된 어떠한 위험성도 가지고 있지 않다. 그의 미립자 특성을 바탕으로, VLP는 면역원성 및 안정성과 관련하여 가용성 항원에 비해 고유의 장점을 제공한다. 서브유닛 또는 단일 재조합 단백질에 비해 VLP는 더 면역원성이어서, B-세포 매개 면역 반응은 물론, CD4 증식성 및 CTL 반응을 자극할 수 있다 (문헌 [Ludwig C. and Wagner R., Curr. Opin. Biotechnol. 2007; 18:537-545]). VLP의 크기는 세포내이입 또는 거대음세포작용을 통하여 수지상 세포 (DC)에 의해 흡수되어 선천성 및 적응성 면역 반응을 활성화하는 데에 유리한 것으로 보인다. VLP, 특히 레트로바이러스 VLP (gag-VLP)는 면역원성 에피토프를 포함하고 있어서, MHC 클래스-I 및 MHC 클래스-II 경로를 통하여 세포성 면역 반응을 자극하는 것으로 생각된다 (문헌 [Deml L. et al., Mol. Immunol. 2005; 42:259-277]). 이러한 면역원성 특성으로 인하여, VLP는 강력한 면역 자극을 달성하는 데에 아주반트의 사용을 필요로 하지 않는 것으로 보인다. VLP는 백신 (WO 2005/123125호) 및 바이러스 혈청학 시약으로서 광범위하게, 그리고 상당히 성공적으로 사용되고 있다.

외막화된 바이러스의 경우, VLP는 바이러스 입자의 조립에 1종 이상의 캡시드 또는 매트릭스 단백질을 필요로 한다. 단백질들은 분아가 이루어지는 세포질 세망 (ER), 지질 래프트 또는 원형질막과 같은 상이한 세포 구획들에서 조립되며, 그에 따라 바이러스 지질단백질 외막을 구성하는 세포성 지질을 포함한다. VLP는 숙주 세포 단백질, 예컨대 지질 래프트 연관 강글리오시드를 포함할 수도 있다. VLP는 단일 또는 다성분 캡시드를 기재로 하는 외래 에피토프 및/또는 표적화 분자의 제공에 활용될 수 있다. 항원과 융합된 B형 간염 바이러스의 코어 유전자가 VLP 접근법의 초기 예를 제공하였었다 (WO 1999/057289호). 오늘날까지, 재조합 CMV VLP는 생성된 바 없다. 생성 및 게재된 가장 큰 VLP는 5종까지의 상이한 단백질들을 포함하는 인플루엔자, 청설병 및 로타바이러스 VLP이다. CMV 캡시드 단백질을 기재로 하여 재조합 CMV 입자를 형성시키는 데에 얼마나 많은 단백질이, 그리고 어떤 단백질이 필요한지에 대해서는 정확하게 알려져 있지 않다. 반면, 많은 비-헤르페스바이러스 캡시드 단백질들이 VLP를 형성하는 것으로 알려져 있다. 가장 눈에 띄는 예는 레트로바이러스 전구체 단백질 gag, 특히 MoMuLV (몰로니(Moloney) 뮤린 백혈병 바이러스), HIV (인간 면역결핍 바이러스), HTLV (인간 T-세포 백혈병 바이러스) 및 SIV (유인원 면역결핍 바이러스) gag이다. pr55 HIV 전구체 단백질은 100-120 nm의 크기를 가지는 VLP를 형성하는데, 다른 단백질들의 운반체로서 작용하는 것으로 나타났다. MoMuLV 전구체 단백질 gag (pr65)는 이뮤노블롯팅 및 ELISA 검정에 기초한 고수율의 115-150 nm의 크기를 가지는 VLP로 이어진다.

바큘로바이러스 발현 벡터 시스템 (BEVS)이 백신 또는 다른 생물제제의 제조를 위한 공동-감염 및 단백질의 공동-발현에 매우 적합한데, 그의 게놈 및 바이러스 구조가 대형 외래 유전자의 삽입을 가능케 하기 때문이다. 주로 나비목 종 (나방 및 나비)에 제한되는 좁은 숙주 범위로 인하여, 그것은 안전하다. 균주 제조 숙주가 곤충 세포이기는 하지만, 바큘로바이러스는 포유동물 세포에서의 재조합 공동-발현에 적용될 수도 있다. 바큘로바이러스 시스템은 전세계의 연구 및 상업용 실험실에서 광범위하게 사용되는 고도로 효율적인 단백질 발현 시스템이다 (문헌 [Roldao A. et al., Expert Rev. Vaccines, 2010; 9(10):1149-1176]). 글락소스미스클라인(GlaxoSmithKline)의 인간 유두종바이러스 (HPV) VLP 백신이 BEVS에서 제조되는데, 미국 및 유럽 연합에서 사용 승인되어 있다 (WO 2005/123125호).

WO 2010/128338호는 인간 시토메갈로바이러스 (HCMV) 폴리에피토프를 추가로 포함하는 헤르페스 심플렉스 바이러스 (HSV) 또는 HSV 바이러스-유사 입자 (HSV VLP)를 포함하는 CMV 백신에 대해 개시하고 있다.

본 발명은 1종 이상의 캡시드 또는 캡시드 전구체 단백질, 3, 4, 5종 이상의 상이한 시토메갈로바이러스 (CMV) 유래 표면 단백질, 및 임의로 1종 이상의 외피 단백질을 포함하는 재조합 바이러스-유사 입자에 관한 것이다.

바람직하게는, 상기 캡시드 단백질은 시토메갈로바이러스, 예컨대 인간 시토메갈로바이러스 (HCMV)와 같은 헤르페스 바이러스, 또는 레트로바이러스, 특히 HIV 또는 MoMuLV로부터 유래한다. 바람직한 캡시드 단백질은 HIV 및/또는 MoMuLV 전구체 gag 단백질이다.

상기 표면 단백질 (외막 단백질로도 지칭됨)은 바람직하게는 HCMV, 특히 gpUL75 (gH), gpUL115 (gL), gpUL55 (gB), gpUL74 (gO), gp100 (gM), gp73 (gN), gpUL128, gpUL130 및 gpUL131A로 이루어진 군으로부터 선택된다. 마찬가지로, 외피 단백질은 바람직하게는 HCMV, 특히 pUL32, pUL45, pUL47, pUL48, pUL69, pUL71, pUL72, pUL76, pUL77, pUL83 (pp65), pUL88, pUL93, pUL94, pUL95, pUL97, pUL99 및 pUL103으로 이루어진 군으로부터 선택된다. 코어 단백질은 특히 외피 또는 외막 단백질 특징 중 어느 하나를 가지는 pUL23, pUL24, pUL33, pUL36, pUL38, pUL43, pUL78, pUL82, pUL96, IRS1, US22 및 TRS1으로 이루어진 군으로부터 선택된다. 마찬가지로, 조절 단백질은 바람직하게는 IE-1, UL50, UL80.5, UL46 및 UL47의 군으로부터 선택된다.

본 발명에 따른 재조합 바이러스-유사 단백질은 또한 B- 및/또는 T-세포 에피토프, 추가적인 외래 항원성 서열, 시토카인, CpG 모티프, g-CMSF, CD19 및 CD40 리간드로 이루어진 군으로부터 선택되는 단백질, 및/또는 형광 단백질, 입자의 정제 목적에 유용하거나 표지를 부착시키는 데에 유용한 단백질, 및/또는 수송 과정에 필요한 단백질성 구조를 추가로 포함할 수 있다.

또한, 본 발명은 본 발명에 따른 바이러스-유사 입자에 포함되어 있는 단백질을 코딩하는 DNA, 그와 같은 DNA를 포함하는 벡터, 특히 바큘로바이러스 벡터, 및 그와 같은 벡터를 포함하는 숙주 세포, 그리고 바큘로바이러스 벡터를 사용한 본 발명에 따른 바이러스-유사 입자의 제조 방법에 관한 것이다.

또한, 본 발명은 본 발명에 따른 재조합 바이러스-유사 입자를 포함하는 백신, 특히 gpUL75, gpUL115, gpUL128, gpUL130 및 gpUL131A로 이루어진 오량체 복합체, 및/또는 gpUL75, gpUL115, gpUL55, gpUL74, gpUL100 및 gpUL73; 또는 gpUL128, gpUL130 및 gpUL131A; 또는 pUL83, IE-1, UL99, UL91 및 pp150으로 이루어진 군으로부터 선택된 가용성 CMV 단백질을 추가로 포함하는 그와 같은 백신에 관한 것이다. 그와 같은 백신은 추가로 알루미늄 히드록시드, 알룸, AS01, AS02, AS03, AS04, MF59, MPL, QS21, ISCOM, IC31, 비메틸화 CpG, ADVAX, RNA 함유 제제 및 프로인트 시약(Freund's reagent)으로 이루어진 군으로부터 선택되는 아주반트는 물론, 상기에서 정의된 바와 같은 본 발명의 DNA도 포함할 수 있다.

구체적인 실시양태에서, 백신은 타운, 톨레도(Toledo), AD169, 메를린(Merlin), TB20 및 VR1814 균주의 군으로부터 선택된 상이한 CMV 균주 유래의 CMV 단백질들을 포함한다.

본 발명에 따른 재조합 바이러스-유사 입자를 포함하는 백신은 또한 프라임-부스트(prime-boost) 투여에서의 gpUL75, gpUL115, gpUL128, gpUL130 및 gpUL131A로 이루어진 오량체 복합체를 사용한 제2 면역화, 및/또는 프라임-부스트 투여에서의 gpUL75, gpUL115, gpUL55, gpUL74, gpUL100, gpUL73, pUL83 및 IE-1로 이루어진 군으로부터 선택된 가용성 CMV 단백질를 사용한 제2 면역화에 의해, 그의 숙주 면역 반응 유도가 강화될 수 있다.

다르게는, 본 발명에 따른 재조합 바이러스-유사 입자를 포함하는 백신은 또한 gpUL73, gpUL74, gpUL75, gpUL100, gpUL115, gpUL128, gpUL130 및 gpUL131A로 이루어진 군에 속하는 2종 이상의 상이한 표면 단백질들로 이루어진 가용성 복합체의 첨가에 의해, 그의 숙주 면역 반응 (체액성 및 세포성 반응) 유도가 강화될 수 있다.

도 1 : 헤르페스바이러스 또는 비- 헤르페스바이러스 캡시드 중 어느 하나를 기재로 하는 상이한 CMV 바이러스-유사 입자 변이체들의 발현, 또는 CMV - 오량체 복합체 및 가용성 CMV 단백질의 발현을 위한 재조합 벡터들의 개략적 도시.
상이한 변이체들은 바큘로바이러스 발현 시스템 (BEVS)을 사용한 재조합 단백질 발현을 목표로 하며, 2개의 프로모터 P1 및 P2 (◁_p10, ▷_polh), 및 SV40 및 HSVtk인 2개의 종결인자 서열 T1 및 T2 (T)를 포함하는 벡터 백본 pRBT136에 삽입된다. 효모에서의 증식의 경우, 벡터는 복제 기점 (O) 예컨대 2미크론(2micron), 및 마커 유전자 (m) 예컨대 URA3을 포함한다. 또한, 벡터는 전달 벡터로부터 바크미드(bacmid)로의 트랜스진의 전위를 위한 트랜스포손 부위 좌측 (TL) 및 우측 (TR), 부위 특이적 동종유래 재조합 (플라스미드 융합)을 위한 loxP 부위 (L), 복제 기점 (O), 암피실린 (A), 클로람페니콜 (C) 및 겐타마이신 (G) 내성 유전자, 그리고 정해진 제한 부위들을 포함한다. 바큘로바이러스를 사용한 형질도입 또는 일시적 발현 중 어느 하나에 의한 포유동물 세포에서의 발현의 경우, 벡터 백본 pRBT393이 추가로 pCMV, ie1 및 lef2에서 선택되는 프로모터, 및 SV40pA, BHGpA 및 HSVtk에서 선택되는 종결인자를 포함한다.
약어: c: 컨센서스 서열; H: His-태그(tag); SH: 스트렙타비딘-His-태그; V: 균주 VR1814, pcI: 프레시션(precission) 프로테아제, pcII: 프레시션 및 TEV 프로테아제, DT: 이량체화 도구, T: 종결인자, O: 복제 기점, G: 겐타마이신 내성, C: 클로람페니콜 내성, L: loxP 부위, TL: 좌측 트랜스포손 측, TR: 우측 트랜스포손 측. 이전의 더 짧은 HCMV 명명법 (gB, gH, gL, gO는 물론, 접두어가 없는 "UL" 및 접미어 "A"가 없는 UL48)이 사용된다. 유전자는 그의 숫자로만, 예를 들면 "UL83" 대신 "83"으로만 표시된다.
도 2 : 서열 14와 조합된 CMV - VLP 변이체 서열 7의 글리세롤- 타르트레이트 구배 기반 정제.
(A) 글리세롤-타르트레이트 구배 기반 정제. SDS-PAGE (4-12% 비스-트리스 겔)에 이어지는 이뮤노블롯팅에 의한 타운 균주 유래 기능성 캡시드, 외피 및 표면 단백질 UL86-UL85-UL50-UL48A-UL46-UL74(gO)-UL83-UL80.5-UL75(gH)-UL115(gL)-UL128(c)-UL130-UL131A (서열 7 및 서열 14)를 포함하는 상이한 CMV-VLP 변이체 분획들의 분석. 외피 단백질의 확인에는 마우스 항-pUL83 (비루시스(Virusys)) 항체가 사용되었다. 좌측에는, kDa로 나타낸 단백질 표준을 나타낸다: 레인 1 내지 13: 분획 1 내지 13 (상부에서 저부로의 분획화), 레인 14: 양성 대조.
(B) 캡시드 (UL86, UL85), 외피 (UL83) 및 표면 UL75 (gH1, gH2) 단백질에 대한 특이적 항체들을 사용한 ELISA 검정에 의한 이뮤노블롯 데이터의 확인. 선택된 단백질들 (UL86, UL85, gH2: 앨라배마 대학교, pUL83: 비루시스; gH1: 산타 크루즈(Santa Cruz))에 결합하는 항체에 의해, 2종의 캡시드, 외피 단백질 (UL83) 및 표면 단백질 UL75 (gH)의 존재를 나타낼 수 있었다. 바큘로바이러스의 존재는 단백질 gp64 (이바이오사이언스(eBioscience))에 대한 항체를 사용하여 확인되었다. x-축의 숫자 1-13은 글리세롤-타르트레이트 구배 (상부에서 저부로 분획화됨)의 번호를 나타내며, 숫자 14는 양성 대조를, 숫자 15는 음성 대조를 나타낸다. VLP에서의 단백질에 대한 항체의 결합 강도는 y-축에 광학 밀도 (OD)로 나타낸다. 동일 분획에서의 선택된 단백질들의 검출은 그들의 공동-국재화를 나타내었으며, 그에 따라 무손상 CMV-VLP를 나타내었다. 서열 9, 서열 10 및 서열 13과 조합된 변이체 서열 7의 발현 및 정제에 대해서도 유사한 결과가 수득되었다.
도 3 : 서열 14와 조합된 CMV - VLP 변이체 서열 5의 글리세롤- 타르트레이트 구배 기반 정제.
캡시드 단백질 UL86 및 UL85, 외피 단백질 UL83 (UL83) 및 표면 단백질 UL75 (gH)에 대한 특이적 항체들을 사용한 ELISA 검정에 의한 이뮤노블롯 데이터의 확인. 선택된 단백질들 (UL86, UL85, gH1: 앨라배마 대학교에 의해 제공된 항체, UL83: 비루시스; gH2: 산타 크루즈)에 결합하는 항체에 의해, 캡시드 (UL86, UL85), 외피 (UL83) 및 표면 단백질 UL75 (gH)의 존재를 나타낼 수 있었다. 바큘로바이러스의 존재는 단백질 gp64 (이바이오사이언스)에 대한 항체를 사용하여 확인되었다. x-축의 숫자 1-13은 글리세롤-타르트레이트 구배 (상부에서 저부로 분획화됨)의 번호를 나타내며, 숫자 14는 양성 대조를, 숫자 15는 음성 대조를 나타낸다. VLP에서의 단백질에 대한 항체의 결합 강도는 y-축에 광학 밀도 (OD)로 나타낸다. 동일 분획에서의 선택된 단백질들의 검출은 그들의 공동-국재화를 나타내었으며, 그에 따라 무손상 CMV-VLP를 나타내었다. 서열 5 및 서열 13으로 구성되는 CMV VLP는 거의 동일한 데이터로 이어졌다. 표면 단백질의 조성을 확인하기 위하여, 서열 9 또는 10과 조합된 서열 5를 기재로 하여 생성된 CMV VLP를 상기 언급된 방식으로 처리하였는데, 0.1-0.3 범위 이내의 유사한 OD 값을 나타내었다.
도 4 : 서열 18과 조합된 CMV - VLP 변이체 서열 3의 글리세롤- 타르트레이트 구배 기반 정제.
캡시드 단백질 (UL85), 외피 (UL83) 및 표면 (UL75 (gH), UL55 (gB)) 단백질에 대한 특이적 항체들을 사용한 ELISA 검정에 의한 이뮤노블롯 데이터의 확인. 선택된 단백질들 (UL85/UL55 (gB1): 앨라배마 대학교; UL83/UL55 (gB2): 비루시스; UL75 (gH): 산타 크루즈)에 결합하는 항체에 의해, 캡시드 (UL85), 외피 (pUL83) 및 표면 단백질 (gpUL75, gpUL55)의 존재를 나타낼 수 있었다. x-축의 숫자 1-7은 글리세롤-타르트레이트 구배 분획 1-7 (상부에서 저부로 분획화됨)의 번호를 나타내며, 숫자 8은 음성 대조를 나타낸다. VLP에서의 단백질에 대한 항체의 결합 강도는 y-축에 광학 밀도 (OD)로 나타낸다. 동일 분획에서의 선택된 단백질들의 검출은 그들의 공동-국재화를 나타내었으며, 그에 따라 무손상 CMV-VLP를 나타내었다. 서열 3을 서열 9, 10, 16 또는 19와 조합하는 것에 의해 동일한 무손상 조성이 관찰되었는데, 이 경우 OD 값 검출은 0.1-0.4 사이로 범위가 다르다.
도 5 : 서열 18과 조합된 CMV - VLP 변이체 서열 2의 글리세롤- 타르트레이트 구배 기반 정제.
외피 (UL83) 및 표면 (UL75, UL55) 단백질에 대한 특이적 항체들을 사용한 ELISA 검정에 의한 이뮤노블롯 데이터의 확인. 선택된 단백질들 (UL83/UL55 (gB): 비루시스; UL75 (gH): 산타 크루즈)에 결합하는 항체에 의해, 외피 단백질 (UL83) 및 표면 단백질 (UL75, UL55)의 존재를 나타낼 수 있었다. 바큘로바이러스의 존재는 단백질 gp64 (이바이오사이언스)에 대한 항체를 사용하여 확인되었다. x-축의 숫자 1은 수크로스 쿠션에 의한 정제-전 샘플을 나타내며, x-축의 레인 2-14는 글리세롤-타르트레이트 구배 분획 1 내지 13 (상부에서 저부로 분획화됨)의 번호를 나타내고, 숫자 15는 VLP에 대한 음성 대조를 나타내며, 숫자 16은 바큘로바이러스에 대한 음성 대조를 나타낸다. VLP에서의 단백질에 대한 항체의 결합 강도는 y-축에 광학 밀도 (OD)로 나타낸다. 동일 분획에서의 선택된 단백질들의 검출은 그들의 공동-국재화를 나타내었으며, 그에 따라 무손상 CMV-VLP를 나타내었다. 상기 언급된 것과 동일한 단백질들이 캡시드 및 외피에 대하여 서열 2로 구성되는 CMV VLP 변이체에서, 그리고 표면 단백질에 대하여 서열 9, 10, 16 또는 19에서도 0.1-0.3의 OD 값 범위로 확인될 수 있었다.
도 6 : 서열 14와 조합된 비- 헤르페스바이러스 캡시드 기재 CMV - VLP 변이체 서열 20의 수크로스 구배 기반 정제.
(A) 수크로스 구배 기반 정제. SDS-PAGE (4-12% 비스-트리스 겔)에 이어지는 이뮤노블롯팅에 의한 캡시드 (레트로바이러스 전구체) 단백질 gag 및 표면 단백질 UL75(gH)-UL115(gL)-UL128(c)-UL130-UL131A (서열 20 및 서열 14)를 포함하는 상이한 CMV-VLP 변이체 분획들의 분석. 캡시드 단백질의 확인에는 마우스 항-gag (다코시토메이션(DakoCytomation)) 항체가 사용되었다. 도표의 좌측은 kDa로 나타낸 단백질 표준을 나타낸다: 레인 1 내지 13: 분획 1-13, 레인 14: 양성 대조 (gag 단백질).
(B) 캡시드 (gag) 및 표면 (UL75 [gH], 스트렙타비딘 태그부착 gL) 단백질에 대한 특이적 항체들을 사용한 ELISA 검정에 의한 이뮤노블롯 데이터의 확인. 선택된 단백질 들 (gag: 다코시토메이션; UL75 (gH): 산타크루즈 사, 스트렙타비딘: AbD 세로텍(Serotec))에 결합하는 항체에 의해, 캡시드 단백질 (gag) 및 표면 단백질 (gH, 스트렙타비딘 태그 경유 gL)의 존재를 나타낼 수 있었다. x-축의 숫자 1-13은 수크로스 구배 분획 1 내지 13 (상부에서 저부로 분획화됨)의 번호를 나타내며, 숫자 14는 VLP에 대한 음성 대조를 나타내고, 숫자 15는 바큘로바이러스에 대한 음성 대조를 나타내며, 숫자 16은 양성 대조를 나타낸다. VLP에서의 단백질에 대한 항체의 결합 강도는 y-축에 광학 밀도 (OD)로 나타낸다. 동일 분획에서의 선택된 단백질들의 검출은 그들의 공동-국재화를 나타내었으며, 그에 따라 무손상 CMV-VLP를 나타내었다. 캡시드 단백질 gag (서열 20)을 서열 9, 10, 13, 15, 16 또는 19의 외피 및 표면 단백질과 조합하는 것에 의해, 동일한 공동-국재화가 관찰될 수 있었다. 서열 19의 포함은 일반적으로 더 높은 OD 값을 나타냄으로써, 더 우수한 CMV VLP의 안정성을 표시하였다.
도 7 : 서열 18과 조합된 비- 헤르페스바이러스 캡시드 기재 CMV - VLP 변이체 서열 20의 수크로스 구배 기반 정제.
(A) 수크로스 구배 기반 정제. SDS-PAGE (4-12% 비스-트리스 겔)에 이어지는 이뮤노블롯팅에 의한 캡시드 (레트로바이러스 전구체) 단백질 gag 및 표면 단백질 UL75-UL115-UL128-UL130-UL131A-UL55 (서열 20 및 서열 18)를 포함하는 상이한 CMV-VLP 변이체 분획들의 분석. 캡시드 단백질의 확인에는 마우스 항-gag (다코시토메이션) 항체가 사용되었다. 좌측에는, kDa로 나타낸 단백질 표준을 나타낸다: 레인 1 내지 13은 상부에서 저부로의 구배 분획화의 분획 1 내지 13에 해당하며, 레인 14는 양성 대조를 나타냄.
(B) 캡시드 (gag) 및 표면 단백질 (UL75 [gH], UL55 [gB])에 대한 특이적 항체들을 사용한 ELISA 검정에 의한 이뮤노블롯 데이터의 확인. 선택된 단백질들 (gag: 다코시토메이션; gB: 비루시스; gH: 산타 크루즈)에 결합하는 항체에 의해, 캡시드 단백질 (gag) 및 표면 단백질 (UL75 [gH], UL55 [gB])의 존재를 나타낼 수 있었다. 바큘로바이러스의 존재는 단백질 gp64 (이바이오사이언스)에 대한 항체를 사용하여 확인되었다. x-축의 숫자 1-13은 수크로스 구배 분획 1 내지 13 (상부에서 저부로 분획화됨)의 번호를 나타내며, 숫자 14는 구배의 적재물(load)을 나타내고, 숫자 15는 양성 대조를 나타내며, 숫자 16은 음성 대조를 나타낸다. VLP에서의 단백질에 대한 항체의 결합 강도는 y-축에 광학 밀도 (OD)로 나타낸다. 동일 분획에서의 선택된 단백질들의 검출은 그들의 공동-국재화를 나타내었으며, 그에 따라 무손상 CMV-VLP를 나타내었다. 서열 22 및 서열 18의 발현에 기반한 추가적인 CMV 변이체는 단백질 UL83에 의한 세포성 면역 반응의 유도를 제공하는 장점을 가짐으로써 유사한 결과로 이어졌다.
도 8 : 친화성 크로마토그래피에 의해 정제된 서열 14와 조합된 His/ 스트렙 -태그부착 CMV-VLP 변이체 서열 7의 분석.
IMAC 절차를 사용하여, 기능성 캡시드, 외피 및 표면 단백질 UL86-UL85-UL50-UL48A-UL46-UL74-UL83-UL80.5-UL75-UL115(His/스트렙)-UL128(c)-UL130-UL131A (서열 7 및 서열 14)를 포함하는 CMV-VLP 변이체를 정제하였다. SDS-PAGE (4-12% 비스-트리스 겔)에 이어지는 마우스-항-UL83 항체 (비루시스)를 사용한 외피 단백질 (UL83)에 대한 이뮤노블롯팅에 의해, 이와 같은 IMAC-정제의 상이한 단계들을 분석하였다. 좌측에는, kDa로 나타낸 단백질 표준을 나타낸다. 레인 1: 정제 전의 VLP (적재물), 레인 2: 유통(flowthrough) (FT), 레인 3: 세척; 레인 4 내지 9: 점증량의 이미다졸 (55, 100, 150, 230, 480, 500 mM)을 사용한 용리, 레인 10: 음성 대조로서의 곤충 세포 (Sf9), 레인 11: 양성 대조 (감염된 Sf9 세포). 외피 단백질의 존재는 화살표로 나타내었음 (UL83).
도 9 : 친화성 크로마토그래피에 의해 정제된 서열 14와 조합된 His/ 스트렙 -태그부착 비- 헤르페스바이러스 캡시드 기재 CMV - VLP 변이체 서열 20의 분석.
IMAC 기반 절차를 사용하여, 캡시드 (레트로바이러스 전구체) 단백질 gag 및 표면 단백질 UL75-UL115(His/스트렙)-UL128(c)-UL130-UL131A (서열 20 및 서열 14)를 포함하는 CMV-VLP 변이체를 정제하였다. SDS-PAGE (4-12% 비스-트리스 겔)에 이어지는 마우스-항-gag 항체 (다코시토메이션)를 사용한 캡시드 단백질 (gag, 도 9A)에 대한 이뮤노블롯팅, 및 스트렙타비딘-His 태그부착 표면 단백질 UL115 (gL, 도 9B)에 대한 이뮤노블롯팅에 의해, 이와 같은 IMAC-정제의 상이한 단계들을 분석하였다. 좌측에는, kDa로 나타낸 단백질 표준을 나타낸다: 레인 1: 정제 전의 VLP (적재물), 레인 2: 유통 (FT), 레인 3: 세척; 레인 4 내지 9: 점증량의 이미다졸 (55, 100, 150, 230, 480, 500 mM)을 사용한 용리, 레인 10: 음성 대조로서의 곤충 세포 (Sf9), 레인 11: 양성 대조 (감염된 Sf9 세포). 캡시드 단백질 (gag)의 존재는 물론, 스트렙타비딘-히스티딘 태그부착 표면 단백질 gL의 존재도 화살표로 표시하였다.
도 10 : His -태그부착 가용성 CMV - 오량체 복합체의 2회의 친화성 크로마토그래피 단계에 이어지는 크기 배제 크로마토그래피로 구성되는 정제 과정의 분석
His-트랩(Trap) 칼럼을 사용한 친화성 기반 크로마토그래피 (IMAC)에 이어지는 크기 배제 크로마토그래피 (XK16/60 슈퍼덱스(Superdex)200pg)에 의해, 표면 단백질 UL75 (His-태그부착, gH)-UL115(gL)-UL128-UL130-UL131A (서열 59)를 포함하는 오량체 복합체를 정제하였다.
(A) SDS-PAGE (4-12% 비스-트리스 겔)에 이어지는 쿠마씨-염색에 의해, 2차 IMAC 정제를 분석하였다. 단백질 표준 (레인 1)의 크기 (kDa)는 좌측에 표시한다. 레인 2: 1차 IMAC의 풀(pool) (2차 IMAC 과정의 적재물), 레인 3: 유통, 레인 4: 세척, 레인 5-14는 500 mM까지의 점증 이미다졸 농도를 가지는 용리 분획을 나타냄.
(B) SDS-PAGE (4-12% 비스-트리스 겔)에 이어지는 쿠마씨-염색에 의한 크기 배제 크로마토그래피 정제의 분석. 단백질 표준 (레인 1)의 크기 (kDa)는 좌측에 표시한다. 레인 1: 침전된 용리 풀 IV-2; 레인 2: 침전되지 않은 용리 풀 IV-2; 레인 3: 용리 풀 IV-3; 레인 4: 용리 풀 V; 레인 5: 용리 풀 VI; 레인 6: 크기 마커. 화살표로 표시된 것은 오량체 복합체의 단백질들 (gH, gL, UL128, UL130, UL131A)이다.
(C) gH의 His-태그에 대한 항체를 사용한 이뮤노블롯. 레인 1은 용리 풀 IV-2 (침전된 것)를 나타냄; 레인 2: 용리 풀 IV-2 (침전되지 않은 것); 레인 3: 용리 풀 IV-3; 레인 4: 용리 풀 V; 레인 5: 용리 풀 VI; 레인 6: 양성 대조. His-태그부착 gH 단백질은 우측에 표시한다.
도 11 : HCMV - VLP 변이체 서열 7 및 서열 10 (A) 그리고 서열 48 및 서열 19 (B)의 전자 현미경사진.
(A) 인 텅스텐산을 사용한 음성 염색에 의한, 캡시드, 기능성 단백질, 외피 단백질 및 표면 단백질 UL86-UL85-UL50-UL48A-UL46-UL83-UL80.5-UL74-UL75-UL115-UL128(c)-UL130-UL131A (서열 7 및 서열 10)를 포함하는 재조합 인간 CMV-VLP의 전자 현미경사진. 축척 막대는 100 nm에 해당한다.
(B) 인 텅스텐산을 사용한 음성 염색에 의한, 캡시드, 캡시드 조립체 지지 단백질, 외피 단백질 및 표면 단백질 UL86-UL85-UL83-UL80.5-UL74-UL75-UL115-UL128-UL130-UL131A-UL55 (서열 48 및 서열 19)를 포함하는 재조합 인간 CMV-VLP의 전자 현미경사진. 축척 막대는 200 nm에 해당한다.
도 12 : 비- 헤르페스바이러스 기재 CMV - VLP 변이체 서열 20 및 서열 10 (A) 그리고 서열 88 및 서열 19 (B)의 전자 현미경사진.
(A) 인 텅스텐산을 사용한 음성 염색에 의한, 캡시드 (레트로바이러스 전구체) 단백질 gag 및 표면 단백질 UL75-UL115-UL128(c)-UL130-UL131A (서열 20 및 서열 10)를 포함하는 재조합 인간 CMV-VLP의 전자 현미경사진. 축척 막대는 100 nm에 해당한다.
(B) 인 텅스텐산을 사용한 음성 염색에 의한, 캡시드 (레트로바이러스 전구체) 단백질 MoMULV gag 및 표면 단백질 UL75-UL115-UL128-UL130-UL131A-UL55-UL83 (서열 88 및 서열 19)를 포함하는 재조합 인간 CMV-VLP의 전자 현미경사진. 축척 막대는 100 nm에 해당한다.
도 13 : 각각 서열 18과의 서열 59 및 서열 22의 백신 조합을 사용한 생체내 연구에 기초한, 마우스 혈청을 사용한 바이러스 중화 검정.
hCMV 항원을 사용하여 프라임-부스트-부스트 요법으로 Balb/C 마우스를 면역화하였다. 이와 같은 중화 검정을 위하여 선택된 항원은 가용성 복합체 (서열 59), 그리고 외피 단백질 UL83 (서열 22) 및 CMV 단백질 UL55-UL75-UL115-UL128-UL130 및 UL131A와 조합된 레트로바이러스 캡시드로 구성되는 VLP의 단백질 혼합물이다. 2-배 연속 희석 (1:20 내지 1:2560)의 8마리 마우스로부터 수득된 혼합 혈청을 CMV 프로모터하에서 EGFP를 발현하는 재조합 BAC-재구성 VR1814 HCMV 균주와 혼합하였다. 처리 96시간 후, MRC-5 섬유모세포 (2×10⁴ 세포/웰)를 사용하여 세포-기반 형광 검정으로 이와 같은 바이러스의 진입을 평가하였다. 비-헤르페스 CMV-VLP와 오량체 CMV 복합체의 혼합물을 사용하여 면역화된 마우스 유래의 선택된 혈청 희석물에 대하여, 상대적 형광 강도 (RFI,%)를 도시한다. 빈 바큘로바이러스 및 PBS를 대조로서 사용하였다. 가용성 오량체 복합체와 비-헤르페스바이러스 기재 CMV VLP의 혼합물을 사용한 면역화는 사용된 EGFP-바이러스의 사전-평가 TCID₅₀을 사용한 인간 혈액 공여자의 역가에 필적하는 역가 범위 1:160 내지 1:320 이내의 중화 항체 생성을 유도하였다.
1: w/o 혈청, 2: 1:320, 3: 1:160, 4: 1:80. Mix: 오량체 및 VLP; BV: 바큘로바이러스.
도 14 : 서열 59를 기반으로 하는 체액성 면역 반응을 확인하기 위한 중화 검정.
인간 CMV 혈액 공여자 및 마우스 혈청의 중화 항체 역가 비교. 2-배 연속 희석 (1:20 내지 1:2560)인 5명의 양성 (군 G2, D6-D10) 및 5명의 음성 (군 G1, D1-D5) HCMV 혈액 공여자 유래의 혈청을 세포-기반 형광 중화 검정에 적용하였다. 오량체 복합체 (서열 59)를 사용하여 미리 면역화된 8마리의 마우스로부터 수득된 혼합 혈청의 1:320 희석물과 동일한 억제 효과를 제공하는 혈청 희석 (s.d.)을 나타낸다. 마우스의 면역화에 사용된 항원 혼합물의 한 구성요소로서의 가용성 오량체 복합체의 별도 분석은 인간 혈액 공여자에 비해 중화 항체의 유도를 나타내었다.
PR: 오량체 면역-전, PO: 오량체 면역-후, G1: 음성 혈액 공여자, G2: 양성 혈액 공여자
도 15 : 가용성 복합체 및 reVLP (재조합 VLP , 서열 22와 서열 18)를 포함하는 백신 후보 중 한 구성요소 (가용성 복합체, 서열 59)의 품질 조절.
IMAC-기반 정제에 적용한 후, 상이한 양의 이미다졸을 사용하여 용리된 분획들을 나타낸다. 그것들을 UL75 (gH) 및 gH 상 His 태그의 존재에 대하여 시험하였다. 신호 강도의 유사성은 gH, 그리고 그에 따른 UL75-UL115-UL128-UL30-UL131A로 구성되는 전체 복합체의 무손상성을 나타낸다.
1: 적재물, 2: 유통, 3: 세척, 4: 250 mM 이미다졸, 5-8: 300 mM 이미다졸, 9-13: 350 mM 이미다졸, 14: 양성 대조, 15: 음성 대조.
도 16 : 입체형태-의존성 항체를 사용한 가용성 복합체 및 reVLP (재조합 VLP, 서열 22/ 18)를 포함하는 백신 후보 중 한 구성요소 (가용성 복합체, 서열 59)의 품질 조절.
샌드위치 ELISA 검정을 사용하여, 지정된 단백질들의 공동-존재에 대해 상이한 복합체 제조 배치들을 시험하였다. 항-gH1 (UL75) 항체를 사용하여 샘플을 포획한 후, 항-gH2 및 항-His는 물론, 항-UL130/131A 및 항-UL130 입체형태-의존성 (UL130/UL131A) 항체를 사용하여 검출하였다. 신호는 복합체 내에서의 단백질들의 공동-존재, 복합체의 무손상성은 물론, 그의 제조의 재현성도 확인해주었다.
1: 배치 451-풀 1, 2: 배치 459-풀 2, 3: 배치 459-풀 1 (15 mM EDTA), 4: 배치 459-풀 1 (20 mM EDTA), 5: 배치 458 (15 mM EDTA), 6: 양성 대조, 7: 음성 대조, 8: 내부 표준.
도 17 : 샌드위치 ELISA 검정을 사용한 비-헤르페스-기재 CMV - VLP (서열 18과 조합된 서열 22)의 확인.
지정된 단백질들의 공동-존재에 대하여 상이한 용리 분획들을 시험하였다. 표면 단백질 UL130 및 UL131A가 자연 입체형태로 존재한다는 표시를 제공하는 입체형태 의존성 항체 (UL130/UL131A)를 사용하여 샘플을 포획하였다. 검출에는 항-gH (UL75), 항-gpUL83 (pp65) 및 항-캡시드 (gag) 항체를 사용하였다. 신호는 VLP에서의 단백질들의 공동-존재를 확인해 주며, 시험된 단백질들 중 일부 샘플의 보강을 밝혀준다.
1: 적재물(bulk), 2: 분획 7, 3: 분획 8, 4: 분획 9, 5: 분획 8+9, 6: 음성 대조, nOD: 정규화된 OD, cap: 캡시드.
도 18 : 샌드위치 ELISA 검정을 사용한 비-헤르페스-기재 CMV - VLP (서열 18과 조합된 서열 22)의 정제 과정 특성화.
지정된 단백질들의 공동-존재에 대하여 2종의 상이한 크로마토그래피 매트릭스 (모노리스(monolith): c1 및 막 흡착제: c2)로부터의 용리 분획들을 시험하였다. 입체형태-의존성 (UL130/UL131A) 항체를 사용하여 샘플을 포획한 후, 항-gH, 항-pp65, 항-gB 및 항-gag (캡시드) 항체를 사용하여 검출하였다. 신호는 VLP에서의 단백질들의 공동-존재를 확인해 주며, 사용된 막 흡착제 (c2)의 더 우수한 성능을 밝혀준다.
1: 칼럼 1 (c1)로부터의 용리 분획, 2: 칼럼 2 (c2)로부터의 용리 분획, 3: 양성 대조, 4: 음성 대조, Cap: 캡시드 (전구체 gag 단백질).
도 19 : 샌드위치 ELISA 검정을 사용한 헤르페스-기재 CMV - VLP의 특성화.
2종 (도 19A, UL86 및 UL80.5, 서열 2) 또는 3종 (도 19B, UL86-UL85-UL80.5, 서열 3)의 상이한 캡시드 단백질들; 동일한 외피 단백질 UL83 (pp65) 및 상이한 표면 단백질들 (gH-gL-gB-UL128-UL130-UL131A, 서열 18)을 사용하여 VLP를 제조하고, 이후 정제 단계로부터의 용리 분획들을 샌드위치 ELISA에 적용하였다. 표면 단백질에 대한 입체형태-의존성 (UL130/UL131A) 항체를 사용하여 샘플을 포획한 후, 외피 및 표면 단백질 (항-pp65, 항-gH 및 항-gB)에 대한 항체를 사용하여 검출하였다. 양 캡시드 유형이 VLP로 이어졌으나, 상이한 수율을 가졌다. gB 단백질의 통합은 3종을 초과하는 단백질로 구성되는 코어의 경우에 유익한 것으로 보였다. 1: 적재물, 2-10: 분획 4-12, 11: 음성 대조.
도 20 : 비-헤르페스 CMV - VLP (서열 22/서열 18) 및 오량체 CMV 복합체 (서열 59)의 조합에 의해 유도되는 세포성 면역 반응.
비장 세포를 수확 24시간 후에 다양한 펩티드들 (1-7)을 사용하여 재-자극하고, 다중 검정을 사용하여 제조자의 프로토콜 (인비트로젠(Invitrogen))에 따라, Th1-유형 시토카인인 IFN-g (A) 및 IL-2 (B), Th2-유형 시토카인인 IL-4 (C), IL-5 (D) 및 IL-10 (E), 그리고 염증성 시토카인인 GM-CSF (F) 및 TNFa (G)의 방출을 측정하였다. 펩티드 2-5는 예상되는 에피토프 (SYFPEITHI 프로그램)를 가지는 구량체의 혼합물이었던 반면, 펩티드 6 및 7은 시중에서 구매하였다 (JPT, 예정된 펩티드들의 혼합물). 빈 바큘로바이러스 및 PBS (모의)를 재-자극에 대한 대조로 사용하였다.
1: 모의, 2: gH, 3: gB, 4: UL128/130, 5: UL131/gL, 6: pp65, 7: Gag 캡시드, Mix: 오량체 및 VLP; BV: 바큘로바이러스.
도 21 : 인간 CMV 양성 혈청을 사용한 백신에 대한 CMV VLP 및 단한 구성요소 (가용성 복합체, 서열 59)의 분석.
샌드위치 ELISA 검정에서 CMV-양성 공여자 유래 인간 항체와 반응하는 해당 능력에 대하여 비-헤르페스 바이러스 기재 CMV VLP (서열 19와 조합된 서열 22), 헤르페스 바이러스 기재 CMV VLP (서열 19와 조합된 서열 48) 및 가용성 복합체 (서열 59)를 시험함으로써, 생체내 실험을 모방하였다. 상이한 CMV 단백질들 (gH, gB, UL83, UL85, UL86 및 입체형태-기반 UL130/UL131A), Gag 및 His에 상응하는 항체들을 사용하여 플레이트를 코팅하였다. 가용성 오량체 복합체 또는 VLP 중 어느 하나를 사용하여 상기 플레이트를 추가로 인큐베이션한 후, 이어서 CMV-양성 인간 혈청 (HIV 음성 공여자)을 사용하여 처리하였다. 검출에는 HRP-표지된 이차 인간 항-IgG를 사용하였다.
(A) 샌드위치 ELISA 검정에서 인간 혈청을 사용하여 오량체 복합체 gH-gL-UL128-UL130-UL131A (서열 59)를 분석하였다. 복합체 중 gH 및 UL130/UL131A는 공여자 혈청 (4종의 상이한 혈청들의 혼합물) 중 인간 항체에 의해 인식된다. 1: 오량체 복합체; 2: 음성 대조 (모의); (3) 양성 대조 (His-발현 단백질).
(B) 샌드위치 ELISA 검정에서 인간 혈청을 사용하여 gag-기재 CMV VLP gag-UL83-gL-gH-UL128-UL130-UL131A-gB-UL83 (서열 19와 조합된 서열 22)을 분석하였다. 이러한 VLP 중 UL83은 공여자 혈청 중 인간 항체에 의해 인식된다. 1: Gag-기재 CMV VLP; 2: 음성 대조 (모의). MoMULV gag 캡시드 (서열 19와 조합된 서열 88)를 기재로 하는 CMV VLP에서 매우 유사한 결과가 수득되었다.
(C) 샌드위치 ELISA 검정에서 인간 혈청을 사용하여 CMV-기재 VLP UL86-UL85-UL83-UL80.5-UL74-gL-gH-UL128-UL130-UL131A-gB-UL83 (서열 19와 조합된 서열 48)을 분석하였다. 이러한 VLP 중 모든 단백질은 UL83, gH, UL85, UL86에 대한 매우 선명한 신호로써 공여자 혈청 중 인간 항체에 의해 인식된다. 1: Gag-기재 CMV VLP; 2: 음성 대조 (모의). CMV VLP 및 가용성 복합체 제조에서의 나머지 바큘로바이러스는 인간 혈청에 존재하는 항체에 결합하지 않았다.

본 발명은 항-HCMV 백신으로서, 치료용 항체의 개발을 위하여, 항-HCMV 치료에, 진단 도구로서, 그리고 R&D 도구로서 사용하기 위한 신규 바이러스-유사 입자에 관한 것이다. 본 발명은 체액성 및 세포성 면역 반응으로 이어지는 재조합 비-감염성 CMV-입자를 생성시키는 몇 가지 가능성에 대해 기술한다. 원하는 특성을 가지는 생성물을 수득하기 위하여, 다양한 단백질 조합들이 생성된다. 더 구체적으로, 본 발명은 다중구성요소 VLP 변이체, 그리고 VLP, 단백질 복합체, 가용성 단백질 및/또는 DNA 기재 성분 예컨대 벡터 및 펩티드와 같은 다양한 단백질 성분들의 조합에 중점을 둔다.

본 발명의 재조합 VLP는 1 내지 6종 단백질들 (주 캡시드, 부 캡시드, 최소 캡시드 단백질 및 조립에 필요한 단백질) 중 어느 하나의 CMV 캡시드 단백질 조합에 의해 형성되는 캡시드, 또는 레트로바이러스 전구체 단백질, 특히 gag로 지칭되는 레트로바이러스 인간 면역결핍 바이러스 (HIV) 중 1종, 및/또는 pr55를 기재로 한다. 이러한 캡시드 단백질에는, CMV 외피 단백질 및 표면 단백질에서 선택되는 추가적인 단백질이 첨가된다. 형성되는 VLP는 분비 과정 동안 숙주 세포에 의해 제공되는 외막에 의해 둘러싸인다. 해당 자연 입체형태로 외피 및 표면 단백질을 연결 및/또는 삽입하기 위해서는, 해당 개별 막 앵커들이 존재한다.

CMV 바이러스는 5종 이상의 캡시드 단백질들 (UL46, UL48A, UL85, UL86, UL104의 유전자 생성물), 19종의 조절 단백질들, 17종의 외피 단백질들 (UL25, UL45, UL47, UL48, UL69, UL71, UL72, UL76, UL77, UL83, UL88, UL93, UL94, UL95, UL97, UL99, UL103의 유전자 생성물), 5종의 표면 또는 외막 단백질들 (UL55 [gB], UL73 [gN], U74 [gO], UL75 [gH], UL100 [gM], UL115 [gL]의 유전자 생성물), 오픈 리딩 프레임 UL128, UL130, UL131A 유래의 비-범주화 유전자 생성물들; 15종의 베타-헤르페스바이러스 고유 유전자 유래 단백질들 (UL23, UL24, UL32, UL33, UL35, UL36, UL38, UL43, UL74 [gO], UL78, UL82, UL96, IRS1, US22, TRS1), 및 지금까지 알려져 있는 오픈 리딩 프레임 (ORF) UL50, UL80.5 유래의 소위 기능성 단백질들을 포함하므로, 이론적으로 1×10⁶⁴개까지의 조합이 가능하게 되며 최대 VLP는 40종을 초과하는 단백질을 포함할 수 있게 되는 바, 이에 따라 조절 단백질은 고려되지 않는다. 지금까지, 이와 같은 바이러스의 복잡성으로 인하여, 재조합 CMV VLP는 존재하지 않는다.

본 발명에서는 "표면 단백질"이라는 용어가 사용되는데, "외막 단백질"이라는 용어와 등가이다.

본 발명은 1종 이상의 캡시드 또는 캡시드 전구체 단백질, 3종 이상의 상이한 시토메갈로바이러스 (CMV) 유래 표면 단백질, 및 임의로 1종 이상의 외피 단백질을 포함하는 재조합 바이러스-유사 입자에 관한 것이다.

본 발명의 바람직한 실시양태에서, 표면 단백질은 바람직하게는 인간 CMV 유래의 pUL83 (pp65), gpUL75 (gH), gpUL55 (gB), gpUL100 (gM), gpUL73 (gN), gpUL74 (gO), gpUL115 (gL), gpUL75 (gH), gpUL128, gpUL130 및 gpUL131A로 이루어진 군으로부터 선택된다. 그럼에도 불구하고, 비-인간 CMV 균주의 단백질이 사용될 수도 있다. 그와 같은 비-인간 CMV 단백질은 이후 VLP에서 면역학적 기능보다는 구조적 기능을 할 수 있다. 본 발명에 따른 재조합 VLP는 HSV (헤르페스 심플렉스 바이러스), EBV (엡스타인-바르 바이러스) 및 KSHV (카포시 육종-관련 헤르페스바이러스)와 같은 다른 헤르페스바이러스 과 유래의 단백질을 포함할 수도 있다.

종 특이성, 상이한 세포 친화성 및 광범위한 면역 반응의 유도에 대처하기 위하여, 본 발명의 VLP는 수많은 캡시드 및 외피 단백질들과의 조합으로써 1종을 초과하는 표면 단백질을 포함한다.

또 다른 바람직한 실시양태에서, CMV 캡시드 단백질 기재 VLP는 6종의 단백질 pUL86, pUL85, pUL48A, pUL46, pUL50 및 pUL80.5에서 선택되는 단백질들 중 1종의 단백질, 또는 그들의 조합 예를 들면 이들 단백질들 중 2종, 3종, 4종, 5종 또는 6종으로 구성된다. 본 발명의 추가적인 측면에서, VLP는 단백질 pUL104를 포함한다.

비-헤르페스바이러스 캡시드는 레트로바이러스 과에 속하는 레트로비리다에(retroviridae), 알파-, 베타-, 감마-, 델타 및 엡실론 레트로바이러스, 렌티바이러스 과 또는 스푸마바이러스 과에서 선택된다. 레트로바이러스 과 중에서는, 고양이 백혈병 바이러스 (FELV), 몰로니 마우스 백혈병 바이러스 (Mo-MuLV), 조류 백혈병 바이러스 (SLV) 또는 뮤린 육종 바이러스 (MSV)와 같이, 조류 (SIV), 고양잇과 (FIV), 소과 (BIV) 및 인간 (HIV) 전구체 단백질 gag (군-특이적-항원)는 물론 감마 레트로바이러스 유래 전구체 단백질 gag가 비-헤르페스바이러스 기재 VLP의 생성을 위한 캡시드로 사용된다. 비-헤르페스바이러스 캡시드 기재의 VLP는 바람직하게는 매트릭스 (MA, p17), 캡시드 (CA, p24), 뉴클레오캡시드 (NC, p7) 및 링크(link) (LI, p6) 단백질 구성요소로 구성되는 전구체 단백질인 HIV 전구체 단백질 gag (pr55)로 구성된다.

gag 전구체 단백질의 조립체는 다른 레트로바이러스 과 구성원과 큰 차이가 없는 것으로 알려져 있다. HIV gag 이외에, 동일한 서브유닛으로 구성되는 MoMULV gag 변이체가 CMV VLP의 형성을 위한 3종을 초과하는 상이한 CMV 외피 및/또는 표면 단백질들을 보유함은 물론 백신의 제조 및 규제 승인에 있어서의 장점을 가지는 레트로바이러스 기재 캡시드로서 적합하다. MoMuLV gag 전구체 단백질을 기재로 하는 CMV VLP 변이체의 조립체는 HIV gag 기재 VLP의 조립체와 유사하다. 수율, 더 우수한 형상 및 입체형태와 관련하여, MoMULV gag 기반 CMV-VLP에 큰 장점은 존재하지 않는다. 그러나, HIV 기재 CMV VLP 인간 백신과 달리, MoMuLV gag 캡시드 기재 CMV-VLP 백신의 경우에는 HIV에 대한 진단 시험에 있어서의 거짓 양성 결과가 예상되지 않는다.

바람직한 VLP는 각 캡시드 단백질의 상부에, UL83, UL25, UL32 (pp150) 및 UL99로 이루어진 군으로부터 선택되는 1종 또는 2종의 외피 단백질, 및 5 내지 8종의 표면 단백질을 포함한다. 표면 단백질들은 바람직하게는 UL75 (gH), UL115 (gL), UL74 (gO), UL55 (gB), UL128, UL130 및 UL131AA로 이루어진 군으로부터 선택된다. 본 발명의 다른 실시양태에서, VLP는 UL100 (gM) 및 UL73 (gN)을 포함할 수도 있다. 본 발명 VLP의 HCMV 중 표면 단백질은 그것이 해당 자연 입체형태로 재조합 캡시드 구조에 발현 및 삽입되도록 해당하는 각 막 앵커와 함께 선택된다.

한 실시양태에서, CMV 캡시드는 균주 캡시드 단백질 (UL86)만을 포함한다. 다른 모든 실시양태에서는, 캡시드가 1종을 초과하는 단백질로 구성된다. 바람직한 실시양태에서, VLP는 외피 단백질 pUL83 및 ppUL32 (pp150), 그리고 표면 단백질 gpUL75 (gH), gpUL115 (gL), gpUL55 (gB), gpUL128, gpUL130 및 gpUL131A와의 조합으로써 pUL86-pUL85-pUL80.5를 포함한다. 역시 바람직하게는, 상기 언급된 외피 및 표면 단백질들은 코어 및 그에 따른 VLP 형상을 개선하는 pUL86-pUL85-pUL48A로 구성되는 캡시드 상에서 발현된다.

또 다른 바람직한 실시양태에서, VLP는 추가로 표면 단백질 gpUL74 (gO)를 포함한다. 이는 입자 형성을 강화하고, 보호 면역 반응을 유도하는 단백질의 양을 증대시킨다.

본 발명의 다른 측면에서, 캡시드 및 외피 단백질은 헤르페스 심플렉스 바이러스, 엡스타인-바르 바이러스, HHV-6 (로세올로바이러스) 또는 HHV-7 (피티리아시스 로세아)와 같은 또 다른 헤르페스바이러스로부터 유래한다.

본 발명의 다른 측면에서, VLP는 비-인간 CMV 기원인 1종 이상의 외피 단백질 및/또는 1종의 표면 단백질을 포함한다.

본 발명의 또 다른 실시양태에서, VLP는 나선-나선 모티프(coiled-coiled motif)를 포함하며 지퍼 기능을 가지고 상응하는 모티프를 보유하는 해당 2종 이상 단백질들을 연결하는 펩티드에 융합되어 있는 2종 이상의 상이한 단백질을 포함한다. 나선-나선 모티프를 포함하는 펩티드에 융합되는 바람직한 단백질은 캡시드 단백질들 중 1종, 바람직하게는 UL86, 그리고 표면 단백질들 중 1종, 바람직하게는 gpUL75로써, 조립체가 기능성인 VLP가 되도록 하며, 표면 상의 면역원성 단백질의 양을 증가시킨다.

본 발명의 한 실시양태에서, 다중구성요소 재조합 VLP의 생성을 위한 단백질은 바람직하게는 타운, 톨레도, AD169, 메를린, VR1814 균주 및/또는 임상 분리주에서 선택되는 단일 CMV 균주에서 선택된다. 또 다른 실시양태에서, VLP의 생성을 위한 단백질은 상이한 CMV 균주들, 바람직하게는 타운, 톨레도, AD169, 메를린, VR1814 균주 및/또는 상이한 임상 분리주들에서 선택된다.

상이한 CMV 균주들로부터 유래하는 단백질 서열들을 포함하는 VLP는 수종의 균주에 대한 보호를 제공하며, 유사한 균주에 의한 재-감염 및/또는 재-활성화를 예방한다. 고려되는 상이한 CMV 균주들은 타운, 톨레도, AD169, 메를린, TB20 및 VR1814 균주는 물론, 기타 임상 분리주들이다.

이러한 균주들은 타운 및 톨레도 균주, 충분히 특성화되어 있는 AD169 기반 데이터, 및 제조 과정의 분석을 위한 시중에서 구입가능한 도구들을 사용한 백신 후보 임상 단계 II 연구의 기존 데이터와 같은 몇 가지 이유로 고려된다. 또한, 임상 분리주 VR1814는 섬유모세포 및 상피/내피 세포와 같은 상이한 세포 유형에의 진입에 중요한 기능성 복합체를 포함한다. 세균 인공 염색체 (BAC) 유래의 실험용으로 적합화된 타운 균주의 경우, 표면 상의 비-기능성 단백질 성분으로 인하여 상피 세포로의 진입이 차단되는 것으로 알려져 있다. 재조합 CMV VLP에서 상이한 균주들을 조합하는 것에 의해, 자연상의 기능장애가 회피되는 것이다. 메를린 및 TB20은 현재 참조 균주로서 더 빈번하게 사용되고 있다. 차-세대 서열분석과 같은 새로운 기술들은 CMV 양성 공여자로부터의 면역원성 에피토프의 확인을 가능케 한다. 상응하는 바이러스 (임상 분리주)의 유전적 정보는 개선된 백신을 생성시키는 데에 사용된다. 따라서, CMV VLP는 상이한 바이러스 균주들로부터 유래하는 단백질들로 구성된다.

바람직한 것은 특히 gpUL55, gpUL74, gpUL75, gpUL115, UL128, UL130 및 UL131A, 그리고 CMV 캡시드 단백질(들) 또는 레트로바이러스 gag 캡시드 단백질 중 어느 하나로 구성되는 VLP에서의 단백질 서열들의 타운 및 VR1814 조합이다.

본 발명의 단백질 성분은 면역원성 단백질들을 포함하며, 그에 따라 바람직하게는 체액성 및 세포성 면역 반응을 자극하는 종류의 수많은 상이한 에피토프들을 포함한다. 에피토프에 의한 체액성 면역 반응의 활성화는 그와 같은 에피토프를 포함하는 단백질에 결합하게 되는 항체의 생성으로 이어진다. 에피토프에 의한 세포성 면역 반응의 활성화는 해당 표면 상에 그와 같은 에피토프를 제시하는 세포를 사멸시키는 세포독성 T 세포 (Tc, CTL, T-킬러 세포, 세포용해성 T 세포, CD8+ T-세포 또는 킬러 T 세포로도 알려져 있음)의 생성으로 이어진다. 본원에서 이해될 때의 에피토프는 반복성일 수 있으며, 더 큰 단백질의 일부, 특히 항원의 일부일 수 있다.

본 발명의 에피토프를 포함하는 상이한 단백질들은 예를 들면 gpUL75 (gH), gpUL115 (gL), UL128, UL130, UL131A, gpUL55 (gB), gpUL74 (gO), gpUL100 (gM), gpUL73 (gN), pUL86, pUL85, pUL80.5, pUL82, pUL83, pUL46, pUL48A, pUL50, pUL32 및 조기 발현 단백질 IE-1이다.

바람직한 실시양태에서, VLP는 더 광범위한 면역 반응을 유도하기 위하여, B- 및/또는 T-세포 에피토프와 조합된 단일 또는 여러 HCMV 균주 및/또는 비-인간 CMV 균주 유래의 에피토프들을 포함한다.

본 발명의 또 다른 측면은 CD 리간드 (예컨대 CD40L, CD19L)의 포함을 동반하는 VLP이다. 그와 같은 VLP는 Th1 또는 Th2 응답을 초래하는 별개의 경로를 통하여 면역 반응을 유도한다.

본 발명의 추가적인 측면은 CpG 모티프, 시토카인 및/또는 베타글루칸을 포함하는 VLP이다. 그와 같은 VLP는 직접적으로 B-세포 활성화를 촉발함으로써, 특정 HCMV 에피토프에 의해 야기되는 면역 반응을 강화하고 광범위화한다.

또 다른 바람직한 실시양태에서, 바이러스-유사 입자는 임의로 바이러스 캡시드 단백질을 추가로 포함하는 완전한 바이러스-유사 표면을 형성하는 단백질로 구성된다. 본 발명의 바이러스-유사 입자는 또한 입자의 정제 목적에, 또는 표지를 부착시키는 데에 유용한 단백질인 형광 단백질, 그리고 수송 과정에 필요한 단백질성 구조를 포함할 수 있다.

본 발명은 상이한 양으로 비-인간 및/또는 인간 시토메갈로바이러스로부터 유래하는 캡시드, 임의로 외피 및/또는 표면 단백질의 다중 조합을 포함하는 재조합 바이러스-유사 입자에 관한 것이다. 이러한 입자는 적어도 캡시드 단백질, 바람직하게는 균주 캡시드 단백질 UL86, ppUL83, ppUL32, pUL25 및 IE-1 단백질의 군으로부터 선택되는 외피 단백질, 및 gpUL75 (gH), gpUL115 (gL), gpUL128, gpUL130, gpUL131A, gpUL55 (gB), gpUL74 (gO), gpUL100 (gM) 및 gpUL73 (gN)로 이루어진 군으로부터 선택되는 표면 단백질을 포함한다. 표면 단백질은 바람직하게는 인간 바이러스 기원의 것이다. 본 발명의 바이러스-유사 입자는 또한 (a) 1종의 HCMV 균주 유래, 또는 (b) 상이한 HCMV 균주들 유래, 및/또는 (c) 마우스 또는 기니 피그 CMV와 같은 비-인간 CMV 유래 중 어느 하나에서 선택되는 다양한 단백질을 포함하는 1종 이상, 예컨대 1 내지 6종의 단백질로 구성된다. 바람직한 것은 단일 HCMV 균주 유래의 1종 이상, 바람직하게는 2종 이상의 상이한 단백질들, 또는 상이한 CMV 균주들 유래의 상이한 단백질들을 포함하는 재조합 바이러스-유사 입자이다. 역시 바람직한 것은 1종 이상의 캡시드 단백질, 외피 단백질 pUL83 및 ppUL32, 그리고 표면 단백질 gpUL55 (gB), gpUL74 (gO), 및/또는 gpUL75 (gH), gpUL115 (gL), gpUL128, gpUL130 및 gpUL131A로 이루어진 군으로부터 선택되는 오량체 구조를 형성하는 단백질들을 포함하는 재조합 바이러스-유사 입자이다. 본 발명의 재조합 바이러스-유사 입자는 비-헤르페스바이러스 캡시드, 바람직하게는 렌티바이러스 전구체 단백질 gag를 기재로 할 수도 있으며, 또한 CMV 표면 단백질들 및 임의로 CMV 외피 단백질들로 구성될 수도 있다.

바람직한 실시양태에서, 본 발명의 바이러스-유사 입자는 하기를 포함한다:

a. 단일 CMV 균주 또는 비-헤르페스바이러스 균주로부터 유래하는 1종의 캡시드 단백질;

b. 단일 CMV 균주로부터 유래하는 2종 이상 캡시드 단백질들의 혼합물;

c. 상이한 CMV 균주로부터 유래하는 2종 이상 캡시드 단백질들의 혼합물;

d. 단일 CMV 균주로부터 유래하는 1종의 캡시드, 1종의 외피 및 1종의 표면 단백질의 조합;

e. 상이한 CMV 균주로부터 유래하는 1종의 캡시드, 1종의 외피 및 1종의 표면 단백질의 조합;

f. 단일 CMV 균주로부터 유래하는 1종 이상 캡시드 단백질; 1종 이상 외피 단백질 및 1종 이상 표면 단백질들의 조합;

g. 상이한 CMV 균주로부터 유래하는 1종 이상 캡시드 단백질; 1종 이상 외피 단백질 및 1종 이상 표면 단백질들의 조합;

h. 추가적인 T-세포 에피토프를 가지는 1종 이상의 CMV 균주로부터 유래하는 1종 이상 캡시드 단백질, 1종 이상 외피 단백질 및 1종 이상 표면 단백질들의 조합;

i. 면역 회피를 담당하는 단백질을 배제한, 1종 이상의 CMV 균주로부터 유래하는 1종 이상 캡시드 단백질, 1종 이상 외피 단백질 및 1종 이상 표면 단백질들의 조합;

j. MHCI 및 MHCII 발현의 억제를 담당하는 단백질을 배제한, 1종 이상의 CMV 균주로부터 유래하는 1종 이상 캡시드 단백질, 1종 이상 외피 단백질 및 1종 이상 표면 단백질들의 조합; 및

k. CD40L, CD19L, 시토카인 및 비메틸화 CpG 모티프의 군으로부터 선택되는 면역 반응을 강화하는 단백질 및/또는 모티프를 추가로 포함하는 1종 이상의 CMV 균주로부터 유래하는 1종 이상 캡시드 단백질, 1종 이상 외피 단백질 및 1종 이상 표면 단백질들의 조합;

l. 예를 들면 His-태그, 스트렙-태그, myc-태그, 플래그(Flag)-태그 및 스냅(Snap)-태그로 이루어진 군으로부터 선택되는 정제 및 분석을 용이하게 하는 단백질, 및 예를 들면 GFP, YFP 및 레드-체리(Red-cherry)로 이루어진 군으로부터 선택되는 형광 단백질을 가지는 1종 이상의 CMV 균주로부터 유래하는 1종 이상 캡시드 단백질, 1종 이상 외피 단백질 및 1종 이상 표면 단백질들의 조합;

m. 화학물질 및/또는 불활성 나노비드를 커플링시키기 위한 추가적인 단백질성 또는 비-단백질 구조를 포함하는 1종 이상의 CMV 균주로부터 유래하는 1종 이상 캡시드 단백질, 1종 이상 외피 단백질 및 1종 이상 표면 단백질들의 조합.

크고 복잡한 CMV VLP를 수득하기 위하여 본 발명에서 제시되는 전략에는 CMV 캡시드, 외피 및/또는 표면 단백질의 유전자를 포함한 단일 벡터 유래의 다수 유전자들의 공동-발현은 물론, 그러한 공동-발현 벡터들 수종의 공동-감염도 포함된다.

이러한 신규 다중구성요소 바이러스-유사 입자, 단백질 복합체 및 가용성 단백질의 제조는 하기의 단계들을 포함하는 재조합 조립 기술 (rePAX로 알려져 있음)을 기반으로 한다: 유전자의 조립, 다양한 시스템을 위한 발현 구축물의 생성, 단백질 발현, 생성물의 정제 및 특성화. 바람직한 플랫폼용 발현 시스템은 바큘로바이러스 시스템 (BEVS) 또는 포유동물 세포 시스템이다. 본 발명의 또 다른 실시양태에서는, BacMam으로 알려져 있는 양 시스템의 조합이 사용된다.

VLP, 단백질 복합체 및 단일 단백질과 같은 본원에서 기술되는 단백질 성분들은 특정의 유전적 도구 및 공정 조작 도구의 사용으로 인하여 더 짧은 시간에 무제한적인 양으로 생성된다. 예를 들면 상기한 rePAX 기술 및 유전자 합성과 같은 현대의 분자 생물학적 방법들에 의해 필요로 하는 유전자를 조립하는 능력은 코딩 DNA 벡터의 빠른 조립을 가능케 한다. 이러한 기술들의 사용은 바이러스-유사 입자, 단백질 복합체 및 가용성 단백질의 개발, 제조 또는 투여시 원래의 잠재적으로 위험한 감염성 또는 발암성 물질의 어떠한 물리적 전달도 필요로 하지 않는다. 따라서, 본 발명의 백신은 안전하다. 본 발명 단백질 성분들의 구축에는, NCBI 데이터베이스에서 가용한 HCMV 유래 뉴클레오티드 서열을 사용하는 것이면 충분하다.

본 발명의 VLP를 형성하는 단백질을 코딩하는 DNA, 그리고 그와 같은 DNA를 포함하는 바이러스 또는 플라스미드 중 어느 하나 기재의 벡터 역시 본 발명의 일부이다.

BEVS 시스템용 발현 구축물의 생성에는, 바람직하게는 이. 콜라이(E. coli) 및 효모 (예컨대 사카로미세스 세레비자에(Saccharomyces cerevisae))에서의 증식 및 곤충 세포에서의 단백질 발현을 위한 요소들을 포함하는 벡터 백본 pRBT136이 사용된다.

포유동물 시스템에서의 발현에는, 바람직하게는 유전자 조립, 동종유래 재조합, 및 포유동물 세포, 바람직하게는 HEK293, CHO, 인간 포피 섬유모세포 (HFF) 및 상피 세포에서의 발현을 위한 요소들을 포함하는 벡터 백본 pRBT393이 사용된다.

상이한 유전자들의 병행 조립은 동종유래 측접 영역을 가지며 발현 카세트 (프로모터-해당 유전자-종결인자)를 포함하는 PCR 생성물, 또는 구제역 바이러스 2A 절단 부위와 같은 프로테아제 절단 부위와 함께 융합된 단일 유전자들의 하나의 오픈 리딩 프레임 (ORF)으로의 동종유래 재조합에 의해 수행된다. 프로모터는 바람직하게는 polh, p10 및 p_XIV 최후기 바큘로바이러스 프로모터, vp39 바큘로바이러스 후기 프로모터, vp39polh 바큘로바이러스 후기/최후기 혼성 프로모터, pca/polh, pcna, etl , p35, egt , da26 바큘로바이러스 초기 프로모터; CMV-IE1, UBc. EF-1, RSVLTR, MT, p_DS47, Ac5, 그리고 P_GAL 및 P_ADH로 이루어진 군으로부터 선택된다. 종결인자는 바람직하게는 SV40, HSVtk 및 BGH (소 성장 호르몬)로 이루어진 군으로부터 선택된다.

본 발명에 바람직하게 사용되는 벡터 백본 pRBT136은 이. 콜라이의 복제 기점, 예컨대 pBR322ori, 및 효모의 복제 기점, 예컨대 2미크론 ori, 곤충 세포에서의 발현을 위한 polh 및 p10 프로모터, 종결인자 SV40 및 HSVtk, 몇 가지 내성 마커 (암피실린, 겐타마이신), 효모 선택 마커 (URA3), 트랜스포손 부위 (Tn) 및 다중 클로닝 부위 (MCS)를 포함한다.

프로모터-해당 유전자-종결인자를 포함하는 발현 카세트는 5' 부위에 35-40 nt의 오버행을 가지며 3' 부위에 추가로 상이한 35-40 nt의 오버행을 가지는 5' 부위에서 증폭된 PCR이다. 동일한 구성을 가지는 제2 발현 카세트와의 동종유래 재조합을 위하여, PCR 생성물은 5' 부위에 이전 PCR 생성물의 3' 부위에 상보성인 35-40 nt 오버행 서열을 포함한다. 첫 번째 PCR 생성물 5' 부위 및 두 번째 PCR 생성물 3' 부위의 나머지 오버행은 각각 선형화된 벡터 (pRBT136)의 3' 및 5' 말단에 대하여 동종유래이다. 이후, 서열에서의 동종유래 재조합은 효모, 바람직하게는 사카로미세스 세레비지아에에서 수행된다. 이전에 기술된 전략에 따라 조립되는 발현 카세트/PCR 생성물의 수는 조립되어야 할 유전자의 필요한 수에 따라 증가된다. 이와 같은 수단에 의해, 다중 유전자/발현 카세트가 병행 조립된다. 조립되는 유전자에는 트랜스포손 부위가 측접한다. 그것은 바큘로바이러스 게놈으로의 유전자의 전위에 사용된다. 생성되는 바큘로바이러스 공동-발현 벡터는 동일한 단일 세포로부터 유전자가 공동-발현되는 것을 보장한다. 수율 및 생성물 조성은 단백질의 수 및 제조 파라미터에 따라 달라진다. 세포주, 감염시 세포 계수 (CCI), 재조합 바이러스 접종물의 양 (감염 다중도, MOI) 및 수확 시간 (TOH)와 같은 제조 파라미터들은 수율 및 조기 수확과 관련하여 매트릭스 시스템 및 소규모 제조시스템 (2-20 ml; 문헌 [Ries, C., John C., Eibl R. (2011), A new scale down approach for the rapid development of Sf21/BEVS based processes - a case study. In Eibl R., Eibl D. (Editors): Single-use technology in Biopharmaceutical Manufacture, 207-213, John Wiley & Sons, Hoboken, New Jersey])을 사용함으로써 결정된다. 이후, 정해진 파라미터들이 대규모로 각 생성물을 제조하는 데에 사용된다. 본 발명의 입자는 높은 제조 용량을 가능케 하는 현대식 일회용 조직 배양 기술을 사용하여 제조된다.

바람직한 본 발명의 제조 세포주는 Sf9, Sf21, Hi-5, 반키린(Vankyrin) (VE-1, VE-2, VE-3), 익스프레스(Express) Sf+ 및 S2 슈나이더(Schneider) 세포와 같은 곤충 세포주이다. 포유동물 세포에서의 발현에는, 특히 인간 세포, 예를 들면 HEK293, CHO, HeLa, Huh7, HepG2, BHK, MT-2, 인간 포피 섬유모세포 (HFF), 골수 섬유모세포, 일차 신경 세포 또는 상피 세포가 사용된다. 효모에서의 발현에는, 에스. 세레비지아에(S. cerevisiae), 에스. 폼베(S. pombe), 씨. 알비칸스(C. albicans) 또는 피. 파스토리스(P. pastoris) 세포가 사용된다.

본 발명에 따른 숙주 세포의 배양 및 증식은 특정 숙주 세포를 위한 적절한 조건을 제공하는 소정의 용기, 생물반응기 또는 일회용 장치에서 수행된다.

본원에서 기술되는 CMV 입자는 초원심분리 기반의 전통적 글리세롤-타르트레이트 및 수크로스 구배, 또는 현대식 크로마토그래피 기반 기술들, 바람직하게는 막 흡착제 및 모노리스와 같은 대형 다공성 매트릭스를 사용하는 친화성 (IMAC) 및 이온 교환 크로마토그래피를 사용하여 정제된다.

본 발명의 바이러스-유사 입자는 치료제로, 및/또는 예방용 백신으로 사용된다. 또한, 그것은 진단 도구에서 항원으로서, 그리고 항체 생성용 항원으로서 사용된다.

예방용 또는 치료용 중 어느 하나인 백신의 양 유형에 있어서, 항원 특이적인 CD8+ 세포독성 T 세포 반응은 물론, 항원 특이적인 CD4+ T 헬퍼 세포 반응이 가장 중요하다. 따라서, VLP의 단백질 성분들은 예를 들면 T-세포 자극인자로 알려져 있는 pUL83을 발현하는 것에 의해 T-세포를 유도하도록 적합화된다. 추가로 예방 백신의 상이한 요건들에 대처하기 위하여, 본 발명은 VLP, 가용성 단백질 복합체 및 단일 단백질의 조합들을 포함한다. VLP의 조합은 면역원성 당단백질 (gpUL75, gpUL55) 및 별개 복합체의 형성에 필요한 단백질 (gpUL115, gpUL128, gpUL130, gpUL131A)을 포함하도록 적합화된다. 이러한 조합에는 가용성 오량체 복합체 [gpUL75 (gH), gpUL115 (gL), gpUL128, gpUL130, gpUL131A]와 바이러스-유사 입자의 조합, 1종 이상 단일 가용성 단백질 (예컨대 pUL83, gpUL55)과 바이러스-유사 입자의 조합, 그리고 바이러스-유사 입자, 오량체 복합체 및 단일 가용성 단백질의 조합이 포함된다. 상기 조합들은 일반적으로 면역 반응을 강화하는 것을 목표로 하여, 중화 항체의 생성 및 장기-지속성 반응을 유도한다. 중화 항체 유도의 경우, 당단백질인 gpUL75 (gH), gpUL115 (gL) 및 gpUL55 (gB)이 필수 목표가 되며, 그에 따라 CMV-VLP, 바람직하게는 HCMV-VLP 표면 상에서 발현된다.

본 발명의 다른 측면은 CMV-VLP 및 가용성 오량체 복합체 (gpUL75 (gH), gpUL115 (gL), gpUL128, gpUL130, gpUL131A)의, 프라임-부스트 요법, 바람직하게는 VLP를 사용하여 프라이밍하고 오량체 복합체를 사용하여 부스팅하는 것에서의 용도이다. 오량체 복합체를 사용하여 프라이밍하는 것 및 VLP 부스트는 적합한 예방접종 체계가 된다. 그와 같은 프라임-부스트 시나리오에서의 VLP와 가용성 단백질 및/또는 VLP와 DNA의 조합은 본 발명의 또 다른 측면이다.

다른 측면에서, 본 발명은 기술된 바와 같은 재조합 바이러스-유사 입자를 포함하는 백신, 특히 gpUL75, gpUL115, gpUL128, gpUL130 및 gpUL131A로 이루어진 오량체 복합체, 및/또는 gpUL75, gpUL115, gpUL55, gpUL74, gpUL100 및 gpUL73; 또는 gpUL128, gpUL130 및 gpUL131A; 또는 pUL83, IE-1, UL99, UL91 및 pp150으로 이루어진 군으로부터 선택된 가용성 CMV 단백질을 추가로 포함하는 그와 같은 백신에 관한 것이다. 그와 같은 백신은 추가로 알루미늄 히드록시드, 알룸, AS01, AS02, AS03, AS04, MF59, MPL, QS21, ISCOM, IC31, 비메틸화 CpG, ADVAX, RNA 함유 제제 및 프로인트 시약으로 이루어진 군으로부터 선택되는 아주반트는 물론, 상기 정의된 바와 같은 본 발명의 DNA도 포함할 수 있다.

선천성 질환의 기회를 감소시키기 위해서는, 모체의 최초 CMV 감염을 방지하는 예방 백신이 바람직한 반면, 모체가 활성의 CMV 감염을 가지고 있는 것으로 진단되는 경우에는 효과적인 치료법을 필요로 한다.

본 발명 VLP의 제약 조성물은 예방법에 사용된다. 인간의 예방접종 방법은 10 ㎍ 내지 10 mg/투여분 범위로 VLP를 포함하는 본 발명의 제약 조성물을 사용한다. 70 kg의 평균적인 인간이 적어도 단일 예방접종을 받는 것으로 가정한다. 바람직하게는, 임의로 최종 면역화 12-24개월 후 즈음의 이차 예방접종이 후속하는 0, 8 및 24주에 적용되는 3회 투여분을 포함하는 투약 요법이 선택된다. 바람직한 투여 경로는 피하 (sc) 및 근육내 (im) 투여이나, 피내 및 비내 역시 적합한 투여이다.

본 발명 VLP의 제약 조성물은 또한 치료적 치료법에도 사용된다. 치료 목적의 인간 예방접종 방법은 10 ㎍ 내지 10 mg/투여분 범위로 VLP를 포함하는 본 발명의 제약 조성물을 사용한다. 70 kg의 평균적인 인간이 적어도 단일 예방접종을 받는 것으로 가정한다. 바람직하게는, 임의로 최종 면역화 12-24개월 후 즈음의 이차 예방접종이 후속하는 0, 8 및 24주에 적용되는 3회 투여분을 포함하는 투약 요법이 선택된다. 본 발명의 제약 조성물은 여성용으로는 5 ㎍ 내지 10 mg/투여분 범위로, 어린이용으로는 이와 같은 투여량의 절반으로 VLP를 포함한다.

치료의 다른 측면에서, 제약 조성물은 프라임-부스트 요법용의 별도 또는 조합된 제약 조성물로서 VLP, 오량체 복합체 및/또는 가용성 단백질을 포함한다. 각 성분은 각각 10 ㎍ 내지 10 mg/투여분의 범위로 사용된다. VLP 및 오량체 복합체 및/또는 가용성 단백질의 조합인 제약 조성물은 각 성분이 10 ㎍ 내지 10 mg/투여분의 범위이다. 상이한 성분 비 역시 가능하다. 70 kg의 평균적인 인간이 적어도 1회의 단일 예방접종을 받는 것으로 가정한다. 바람직하게는, 임의로 최종 면역화 12-24개월 후 즈음의 이차 예방접종이 후속하는 0, 8 및 24주에 적용되는 3회 투여분을 포함하는 투약 요법이 선택된다. 바람직한 투여 경로는 피하 (sc) 및 근육내 (im) 투여이나, 피내 및 비내 역시 적합한 투여이다.

본 발명의 치료 방법은 실질 장기(solid organ), 골수 및/또는 줄기 세포 이식 수용자에게 특히 중요하다. 이러한 환자들의 경우, 빠르고 효과적인 CD8+ 및 CD4+ T-세포 반응이 매우 중요하다. 이와 같은 문제에 대체함에 있어서, 본 발명의 조성물은 10 ㎍ 내지 10 mg/투여분의 범위이다. 70 kg의 평균적인 인간이 적어도 1회의 예방접종을 받는 것으로 가정한다. 바람직하게는, 임의로 이식 1, 4, 8주 후 즈음의 이차 예방접종이 후속하는 이식 0, 2 및 4주 전에 적용되는 3회 투여분을 포함하는 투약 요법이 선택된다.

본 발명에 따른 백신은 수용액 중의 재조합 바이러스-유사 입자, 오량체 복합체 및/또는 가용성 단백질, 그리고 임의로 또한 현행 기술에 알려져 있는 바와 같은 점도-조절 화합물, 안정화 화합물 및/또는 면역원성을 증가시키는 아주반트를 포함한다.

실시예

실시예 1: 재조합 발현 벡터 RBT136 -7 및 RBT136 -9의 구축

BEVS 시스템용 발현 구축물의 생성에는, 이. 콜라이 및 효모 (예컨대 사카로미세스 세레비자에)에서의 증식 및 곤충 세포에서의 단백질 발현을 위한 요소들을 포함하는 벡터 백본 pRBT136을 사용한다. 다양한 VLP 변이용으로, 캡시드, 외피 및 표면 단백질을 제공하는 상이한 유전자들을 선택하였다.

상기 유전자들은 스포돕테라 프루기페르다(Spodoptera frugiperda) 용으로 특별하게 최적화된 유전자 합성에 의해 생성되며, 하기의 시토메갈로바이러스 유전자 군으로부터 선택된다: 첫 번째로 캡시드 구획은 예를 들면 pUL86, pUL85, pUL46, pUL48, pUL50 및 pUL80.5 (UL80A); 두 번째로 외피 부분은 예를 들면 pUL83, pUL25, ppUL32 및 pUL99; 그리고 세 번째로 표면 부분은 예를 들면 gpUL55 (gB), gpUL75 (gH), gpUL115 (gL), gpUL74 (gO), gpUL100 (gM), gpUL73 (gN), gpUL128, gpUL130 및 gpUL131A. HCMV 캡시드를 구성하기 위하여, 임의로 기능성 유전자 pUL48a 및 pUL50과 조합된 pUL86, pUL85, pUL46 및 pUL80a의 다중 유전자 조합을 사용하였다. 선택된 외피는 pUL83인 반면, 표면은 gpUL55 (gB), gpUL75 (gH), gpUL115 (gL), gpUL74 (gO), gpUL128, gpUL130 및 gpUL131A로부터 제조하였다.

프로모터-유전자-종결인자 유형의 다양한 발현 카세트를 나타내는 PCR 생성물들의 동종유래 재조합에 의해, 제2 발현 벡터에서의 gpUL75 (gH)-gpUL115 (gL)-gpUL128-gpUL130-gpUL131A의 조립은 물론, 하나의 발현 벡터로의 pUL86-pUL85-pUL50-pUL48-pUL46-pUL83-pUL80.5-gpUL74 (gO)의 병행 조립을 수행하였다. 벡터 백본 pRBT136은 이. 콜라이 및 효모의 복제 기점, 곤충 세포에서의 발현을 위한 polh 및 p10 프로모터, 종결인자 SV40 및 HSVtk, 수종의 내성 마커 (암피실린, 겐타마이신), 트랜스포손 부위 (Tn) 및 다중 클로닝 부위 (MCS)를 포함한다. 프로모터-UL86-종결인자를 포함하는 발현 카세트는 프라이머 RBT155 (TGATTTGATAATAATTCTTATTTAAC, 서열 63)를 사용하여 5' 부위에서, 그리고 35-40 nt 오버행 (GGCTAGCTTTGTTTAACTTTAAGAAGGAGATACATCTAGA, 서열 64)을 가지는 3' 부위에서 증폭된 PCR이었다. 프로모터-UL85-종결인자를 포함하는 발현 카세트와의 동종유래 재조합의 경우, 이와 같은 부분은 상기 PCR 생성물 C-말단 단부의 35-40 nt 오버행에 상보성인 서열을 사용하여 N-말단 단부에서 증폭된 PCR이었다. 동종유래 재조합은 효모 (사카로미세스 세레비지아에)에서 수행하였다. 밤샘 배양물을 25℃에서 5분 동안 500×g로 원심분리한 후, 상청액을 흡인하고, 물 및 트리스-EDTA-LiOAc 완충제를 사용하여 펠렛을 세척하였다. EcoRI 및 HindIII (1 μl)를 사용하여 선형화된 벡터, 연어 정자 DNA (8 μl), 및 발현 카세트를 나타내는 PCR 생성물 (1-4 μl)을 50 μl의 세척된 효모에 첨가하고, 30℃에서 30분 동안 인큐베이션한 후, 이어서 42℃에서 열 충격을 가하고, 우라실 없이 각 아미노산이 점적된 아가 플레이트 상에 플레이팅하여, 3일 동안 인큐베이션하였다. 냉동 (액체 질소, 2분)-해동 (95℃, 1분)-용해에 의해, 생성 벡터를 효모 세포로부터 단리하였다. 동일 부피 클로로포름의 첨가 후, 2배 부피의 에탄올을 사용하여 벡터를 침전시켰다. 침전된 벡터 (5 μl)를 50 μl의 적격 XL-1 블루 (스트라타젠(Stratagene))에 첨가한 후, 이어서 제조자의 프로토콜에 따라 형질전환시켰다. 30분 동안의 얼음상 인큐베이션 후, 42℃에서의 45초 동안의 열 충격, 4℃에서의 2분 냉 충격, 2YT 배지 200 μl의 첨가, 및 220 rpm에서 37℃로의 1시간 인큐베이션이 이어졌다. 다음에, 배양물을 100 ㎍의 암피실린 및 100 ㎍의 겐타마이신을 포함하는 2YT 아가 플레이트 상에 플레이팅하였다. 모든 조립된 유전자들의 존재를 입증하기 위하여, PCR 스크리닝, 분석용 분해 및 서열분석에 의해 성장된 클론을 확인하였다.

유전자 UL83 및 UL80.5를 벡터 pRBT4에 조립하고, cre-lox 재조합에 의해 pUL86-pUL85-pUL50-pUL48-pUL46-gpUL74 (gO)를 포함하는 pRBT136과 조합하였다. 1 μl의 cre-레콤비나제를 10 μl의 총 부피로 500 ng의 pRBT5 및 pRBT136에 첨가하고, 37℃에서 30분 동안 인큐베이션하였다. 70℃에서의 10분 열 불활성화 후, 상기한 바와 같이 XL-1 블루 적격 세포에서의 형질전환을 수행하였다. PCR 스크리닝, 분석용 분해 및 서열분석에 의해 클론을 확인하였다. 서열분석된 플라스미드를 상응하는 바큘로바이러스 게놈 (바크미드)의 생성에 사용하였다. Tn7 유도 전위를 통한 부위-특이적 동종유래 재조합에 의해, 적격 DH10MB 세포로 해당 유전자를 전달하였다. 10 ng의 서열분석된 플라스미드를 100 μl의 적격 DH10MB 세포에 첨가하고, 4℃에서 30분 동안 인큐베이션하였다. 42℃에서의 45초 동안의 열 충격, 4℃에서의 2분 냉 충격, 2YT 배지 400 μl의 첨가, 및 220 rpm에서 37℃로의 4시간 인큐베이션 후, 내성 마커에 따른 항생제 및 청색-백색 스크리닝을 위한 IPTG/X-gal을 포함하는 적절한 2YT 아가 플레이트 상에 1:10 희석물을 플레이팅하였다. 올바른 클론을 선택하여 팽창시킨 후, 비른보임과 돌리의 방법(Birnboim & Doly method) (문헌 [Nucleic Acids Res. 1979; 7(6):1513-23])을 사용하여 DNA를 단리하였다. 시약 푸젠(Fugene) (3 μl, 스위스 소재 로슈(Roche))을 사용하여 곤충 세포의 최초 형질감염 (Sf9, 1×10⁶ 세포/6-웰) 용으로 4종의 올바른 바크미드 클론들 (각각 1 ㎍)을 선택함으로써, 재조합 시드 바이러스 (V₀)를 생성시켰다. 마스터 시드 바이러스 (V₁) 및 작용 시드 바이러스 (V₂)의 생성을 위하여, 200 ml의 배양물 중 0.05 pfu/세포의 감염 다중도 (MOI)를 사용하여 이와 같은 바이러스의 2회 연속 증폭을 수행하였다. 전통적 플라크 검정에 의해, 작용 시드 바이러스의 감염 역가를 측정하였다. 바이러스 희석물 (1 ml의 부피 중 10⁵ 내지 10⁸개)을 1×10⁶ 세포/6-웰의 Sf9 세포 배양물에 첨가하고, 27℃에서 1시간 동안 인큐베이션하였다. 바이러스 흡인 후, 세포를 Sf900-1.3 배지 중 4% 아가로스로 덮은 후, 이어서 가습 챔버에서 27℃로 인큐베이션하였다. 상이한 구축물들의 감염 역가는 1-5×10⁷ pfu/세포의 범위였다.

50 ml 생물반응기 (컬티플라스크(Cultiflask), 사르토리우스 스테딤(Sartorius Stedim))에서 20 ml 곤충 세포 배양물의 감염에 의해, 세포주, 감염시 세포 계수 (CCI), 재조합 바이러스 접종물의 양 (감염 다중도, MOI) 및 수확 시간 (TOH)와 같은 제조 파라미터들을 측정하였다. 상이한 CCI (0.5; 1, 2×10⁶ 세포/ml), MOI (0.1, 0.4, 1, 2, 4) 및 수확 시간 (TOH)의 매트릭스를 7일 동안 수행함으로써, 수율과 관련하여 최상의 제조 파라미터를 결정하였다 (문헌 [Ries, C., John C., Eibl R. (2011), A new scale down approach for the rapid development of Sf21/BEVS based processes - a case study. In Eibl R., Eibl D. (Editors): Single-use technology in Biopharmaceutical Manufacture, 207-213, John Wiley & Sons, Hoboken, New Jersey]). 매일 샘플링하여 세포 계수 및 생존력을 측정하는 것에 의해 제조를 조절하였다. 샘플은 이뮤노블롯팅 및 ELISA에 의해 분석하였다. 최고 강도 (도트 블롯(Dot blot)) 및 최고 OD (ELISA)로서 평가된 수율과 관련한 최상의 제조 파라미터는 2×10⁶ 세포/mL의 감염 세포 계수 (CCI) 및 공동-감염에 사용된 각 바이러스의 MOI 0.2로써 감염 3일 후 (p.i.)에 달성되었다.

이뮤노블롯팅을 위하여, 100 μl의 세포 배양물 샘플을 도트-블롯 챔버 (바이오라드(BioRAD))를 사용한 여과에 의해 니트로셀룰로스 막 (바이오라드)에 적용하였다. 5% 비-지방 건조-우유 트리스Cl-트윈20 (0.1%) 용액을 사용하여 30분 동안 비특이적 결합 부위를 차단한 후, 외피 단백질 UL83에 대한 항체와 함께 4℃에서 밤새 막을 인큐베이션하였다. 알칼라인-포스파타제 커플링된 이차 항-마우스 항체 (셀 시그널링(Cell signaling))를 사용한 인큐베이션 후, NBT/BCIP (써모피셔(ThermoFisher)) 용액을 사용하여 단백질 검출을 수행하였다.

ELISA 검정을 위하여, 모든 수집된 세포 배양물 샘플들을 96-웰 사전-흡수 ELISA 플레이트 (눈크(Nunc))에서 100 μl/웰의 코팅 완충제 (0.1 M Na₂HPO₄, pH 9)에 1:10으로 희석하고, 4℃에서 밤새 인큐베이션하였다. 이후, 195 μl/웰의 세척 완충제 (1× PBS, 0.05% 트윈20)를 사용하여 플레이트를 3회 세척한 후, 이어서 195 μl/웰의 1× PBS 용액 중 3% BSA를 사용하여 실온에서 1시간 동안 차단하였다. 3회 세척 단계 후, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중 1 ㎍/ml 농도의 특이적 항체를 첨가하고 (100 μl/웰), 실온에서 1시간 동안 인큐베이션하였다. 표면 단백질 gH의 검출에는 마우스-항-gH (산타 크루즈) 항체를 사용한 반면, 외피 단백질 UL83은 마우스-항-UL83 항체 (비루시스)를 사용하여 확인하였다. 3회 세척 단계 후, 적절한 이차 항체 (항-마우스-IgG-HRP, 3% BSA, 1× PBS, 0.05% 트윈 20, pH 7 중 1:1000 희석물)를 사용한 1시간 인큐베이션을 수행하였다. 100 μl/웰의 TMP 기질 시약 (미국 샌디에고 소재 BD 바이오사이언시스(Biosciences): 제조자의 프로토콜에 따름)을 사용하여 VLP에 대한 특이적 항체 (UL83, gH)의 결합을 검출하고, 이어서 3-15분 후에 100 μl의 1 M HCl을 사용하여 반응을 중지한 후, 마이크로플레이트 판독기에서 450 nm로 OD를 측정하였다.

CMV-VLP 변이체의 생성을 위한 하기의 발현 벡터 (pRBT136-x)를 실시예 1에 기술되어 있는 바와 같이 처리하였다.

약어: c: 컨센서스 서열; H: His-태그; SH: 스트렙타비딘-His-태그; V: VR1814, pcI: 프레시션 프로테아제, pcII: 프레시션 및 TEV 프로테아제, DT: 이량체화 도구. 표 1의 유전자 기술에는, 더 짧은 HCMV 명명법 (gB, gH, gL, gO는 물론, 접두어가 없는 "UL" 및 접미어 "A"가 없는 UL48)이 사용된다.

실시예 2: 발현 벡터 pRBT136CMV -1; pRBT136CMV -8 및 pRBT136CMV -20

발현 벡터 pRBT136CMV-1; pRBT136CMV-8 및 pRBT136CMV-20을 수득하기 위하여, 각 해당 유전자, 즉 UL86, UL55 (gB) 및 gag를 BamHI (5') 및 HindIII (3') 분해 및 동일한 효소를 사용하여 절단된 백본 pRBT136에의 결찰에 의해 p블루스크립트(pBluescript) 벡터로부터 서브클로닝하였다. 총 부피 20 μl 중 2 ㎍의 절단된 pRBT136, 10 ㎍의 단편 및 1 μl의 T4-리가제 (NEB)를 사용하여 결찰을 수행한 후, 이어서 실시예 1에 기술되어 있는 바와 같이 적격 XL-1 블루 세포에 형질전환시켰다.

실시예 3: 캡시드 변이체 pRBTCMV - 2용 발현 구축물

CMV-VLP의 생성을 위한 캡시드 변이체 pRBTCMV-2용 발현 구축물을 수득하기 위하여, UL86을 포함하는 발현 카세트 및 UL83을 가지는 또 다른 것을 실시예 1에 기술되어 있는 바와 같이 병행 조립하였다. UL80.5 발현 카세트의 통합은 실시예 2에 기술되어 있는 바와 같은 결찰에 의한 정방향 프라이머 RBT204 (TGCTGCCCACCGCTGAGCAATAACTATCATAACCCCCGGAATATTAATAGATCATGG, 서열 65) 및 역방향 프라이머 RBT189 (GTAGCGTCGTAAGCTAATACG, 서열 66)를 사용한 PCR 생성물의 결찰에 의해 수행하였다.

실시예 4: 캡시드 변이체 pRBTCMV - 3용 발현 구축물

캡시드 변이체 pRBTCMV-3용 발현 구축물을 생성시키기 위하여, 제한 효소 AvrII를 사용하여 변이체 pRBTCMV-2의 플라스미드를 절단하였다. 프라이머 pRBT526 (5') 및 pRBT189 (3')를 사용하여 유전자 UL85를 가지는 발현 카세트를 증폭시킨 후, 실시예 1에 기술되어 있는 바와 같은 동종유래 재조합에 의해 플라스미드 pRBTCMV-2에 도입하였다.

실시예 5: CMV - VLP 변이체 5의 발현, 정제 및 특성화

체계적인 최적화 (실시예 1) 후 정해진 단백질 발현 파라미터들에 따라, 일회용 1 L 진탕 플라스크 (배양 부피 300 mL) 중 조밤나방(fall army worm) 스포돕테라 프루기페르다 세포 (Sf9)에서 각각 다수의 유전자들을 포함하는 2종 바큘로바이러스 (서열 5 및 서열 12)의 공동-감염에 의해, UL86-UL85-UL50-UL48-UL46-UL83-UL80.5-UL74-gH-gL-UL128-UL130-UL131A를 포함하는 바이러스-유사 입자 (VLP)를 제조한다. 제조 파라미터들은 하기와 같다: 최초 감염시 세포 계수 (CCI) 2×10⁶ 세포/ml, 감염 다중도 (MOI) 0.4 pfu/ml, 각 바이러스 당 0.2 pfu/ml, 27℃에서 100 rpm으로 인큐베이션. 감염 후 3일차 (p.i.)에 80% 가량의 생존력에서 수확을 수행하였다. 매일 샘플링하여 세포 계수 및 생존력을 측정함으로써 제조를 조절하였다. 100 kDa의 분자량 컷오프 (MWCO) 및 0.02 m²의 여과 면적을 가지는 하이드로사르트 사르토콘 슬라이스200(Hydrosart Sartocon Slice200) 카세트 (사르토리우스 스테딤)에 의한 접선-유동-여과를 사용하여, 80 ml/분의 유량 및 1-1.5 bar 사이의 막횡단 압력에서, VLP 함유 상청액을 3×로 농축하였다. 잔류물을 2-단계 글리세롤-타르트레이트 구배 초원심분리에 의한 정제에 적용하였다. 첫 번째 단계에서는, 25 ml의 잔류물을 6 mL의 30% 수크로스 쿠션 (50 mM 트리스, 100 mM NaCl, pH 7.4 중 w/v) 상에 덮고, SW28 로터를 사용하여 16000 rpm 및 16℃에서 1.5시간 동안 펠렛화하였다. 상기 펠렛을 0.5 ml TN-완충제 (50 mM 트리스, 100 mM NaCl, pH 7.4)에 재현탁하였다. 글리세롤-타르트레이트 구배 (15-35% 타르트레이트와 혼합된 30% 글리세롤, 12 ml 부피)를 제조하고, 0.5 ml의 정제-전 물질로 덮은 후, SW41 로터를 사용하여 24000 rpm 및 16℃에서 16시간 동안 원심분리하였다. 상기 구배를 상부로부터 0.9 ml 분획으로 분획화하고, 정제된 VLP를 생화학적 방법에 의해 분석하였다. 150 μl의 상이한 구배 분획들을 제조자의 프로토콜에 따라 4-12% 비스-트리스 NuPAGE 겔 (인비트로젠) 상에 적재하고, MOPS 전개 완충제를 사용하여 150 V로 15분 동안, 그리고 180 V로 45분 동안 전개시켰다. 심플리블루 세이프스테인(SimplyBlue SafeStain) 시약 (인비트로젠)을 사용하여 겔을 밤새 염색하고, 물을 사용하여 탈색하였다.

이뮤노블롯팅을 위하여, 반-건조 장치 (바이오라드)를 사용하여 19V에서 1시간 동안, 단백질을 니트로셀룰로스 막 (바이오라드) 상으로 전달하였다. 5% 비-지방 건조-우유 트리스HCl-트윈20 (0.1%) 용액을 사용하여 30분 동안 비특이적 결합 부위를 차단한 후, 외피 단백질 pUL83과 같은 특이적 단백질들에 대한 항체를 사용하여 4℃에서 밤새 막을 인큐베이션하였다. 단백질 검출은 알칼라인-포스파타제 커플링된 이차 항-마우스 항체 (셀 시그널링)를 사용한 인큐베이션 후, NBT/BCIP (써모피셔) 용액을 사용하여 수행하였다.

총 단백질은 96-웰 플레이트 포맷 (BCA, 피어스(Pierce))에 적합화된 브래드포드(Bradford) 검정을 통하여 측정된다. 20 μl의 미지 또는 표준 샘플을 180 μl의 완충제에 희석하였다. 3반복으로 표준에 대하여 (순수 소 혈청 알부민), 또는 미지 샘플에 대하여 일련의 2-배 희석물들을 제조한다. 웰마다 100 μl의 2× 모 브래드포드 시약 (피어스)을 첨가하였다. 다음에, 플레이트를 혼합하고, 마이크로타이터 플레이트 판독기에서 595 nm로 흡광도를 측정하였다. 외피 UL83에 대한 특이적인 항체 (마우스-항-UL83, 비루시스) 및 표면 단백질 gH (마우스-항-gH, 산타 크루즈)에 대한 특이적인 항체의 결합을 조사하는 것에 의해, 글리세롤-타르트레이트 구배를 분획화함으로써 수득된 상이한 분획에 포함되어 있는 CMV-VLP를 추가로 분석한다. 이에 따라, 상이한 구배 분획들을 96-웰 사전-흡수 ELISA 플레이트에서 100 μl/웰의 코팅 완충제 (0.1 M Na₂HPO₄, pH 9) 중에 1:10으로 희석한 후, 4℃에서 밤새 인큐베이션하였다. 이후, 195 μl/웰의 세척 완충제 (1×PBS, 0.05% 트윈20)를 사용하여 플레이트를 3회 세척한 후, 이어서 195 μl/웰의 1× PBS 용액 중 3% BSA를 사용하여 실온에서 1시간 차단하였다. 3회 세척 단계 후, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중 1 ㎍/ml의 농도로 특이적 항체인 항-표면 항체 (항-gH)는 물론, 항-외피 항체 (항-UL83)를 첨가하고 (100 μl/웰), 실온에서 1시간 동안 인큐베이션한 후, 추가적인 3회 세척 단계가 이어졌다. 검출을 위하여, 적절한 이차 항체 (항-마우스-IgG-HRP, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중에 1:1000 희석)를 사용한 1시간 인큐베이션을 수행하였다. 100 μl/웰의 TMP 기질 시약 (미국 샌디에고 소재 BD 바이오사이언시스; 제조자의 프로토콜에 따름)을 사용하여 VLP에 대한 특이적 항체의 결합을 검출하였는데, 이를 위하여 3-15분 후 100 μl의 1 M HCl을 사용하여 반응을 중지하고, 이어서 마이크로플레이트 판독기에서 450 nm로 OD를 측정하였다.

하기의 표 2는 실시예 5에 기술되어 있는 바와 같이 발현, 정제 및 특성화된 CMV-VLP 변이체들의 개관이다. 표 1에 기술되어 있는 유전적 구축물들은 상응하는 바큘로바이러스의 생성과 같은 추가적인 조작에 그것을 사용하기 전에 서열분석에 의해 품질을 조절하였다. 생성된 바큘로바이러스의 완전성은 각 단일 유전자의 존재에 대한 PCR 기반 트랜스진 조절에 의해 품질을 조절한다. 특히 이러한 CMV VLP의 면역원성 표면 단백질의 단백질 수율 및 공동-국재화와 같은 제조 및 규제 승인을 위한 가장 중요한 특성들을 표 2에 언급한다.

실시예 6: 오량체 CMV 복합체의 발현, 정제 및 특성화

체계적인 최적화 (VLP 경우의 실시예 1)를 기반으로 정해진 단백질 발현 파라미터들에 따라, 일회용 2 L 진탕 플라스크 (배양 부피 700 mL) 중 조밤나방 스포돕테라 프루기페르다 세포 (Sf9)에서 단일 바큘로바이러스 (서열 59)로부터의 공동-발현에 의해, gpUL75 (gH-His)-gpUL115 (gL)-gpUL128-gpUL130-gpUL131A를 포함하는 오량체 CMV 복합체를 제조한다. 제조 파라미터들은 하기와 같다: 최초 감염시 세포 계수 (CCI) 2×10⁶ 세포/ml, 감염 다중도 (MOI) 0.25 pfu/ml, 27℃에서 100 rpm으로 인큐베이션. 감염 후 3일차 (p.i.)에 80% 가량의 생존력에서 수확을 수행하였다. 매일 샘플링하여 세포 계수 및 생존력을 측정함으로써 제조를 조절하였다. 복합체 함유 상청액을 2× 5 ml His 트랩 칼럼 (GE 헬스케어(Healthcare)에 적재하였다. 50 칼럼 부피 (CV, 500 ml와 등가)에 걸쳐 이미다졸 0에서 500 mM까지의 선형 구배를 사용하여 복합체를 정제하였다. 상이한 크로마토그래피 분획들을 생화학적 방법에 의해 분석하였다. 150 μl의 상이한 분획들을 아세톤을 사용하여 침전시키고, 30 μl의 20 mM 트리스, 150 mM NaCl 완충제, pH 7.4에 재현탁하였다. 4-12% 비스-트리스 NuPAGE 겔 (인비트로젠)에의 적재를 위하여, 4× 적재 염료를 제조자의 프로토콜에 따라 첨가하고, 이어서 MOPS 전개 완충제를 사용하여 150V로 15분 동안, 그리고 180V로 45분 동안 전기영동하였다. 심플리블루 세이프스테인 시약 (인비트로젠)을 사용하여 겔을 밤새 염색하고, 물을 사용하여 탈색하였다. 농축 및 추가 정제를 위하여, 1 ml His 트랩 칼럼을 사용한 0-500 mM 이미다졸 50 칼럼 부피에 걸친 선형 구배에 의해, 2차 IMAC 크로마토그래피를 수행하였다. 쿠마씨 염색된 SDS-PAGE 및 항-His 항체를 사용한 이뮤노블롯팅에 의해, 1차 IMAC 단계와 같이 상이한 분획들을 분석하였다. 모든 복합체 함유 분획들을 혼합하고, 50 kDa 컷오프의 아미콘(Amicon) 필터 장치 (밀리포어(Millipore))를 사용하여 5 ml의 최종 부피로 농축한 후, 최종 정제 단계를 위하여 크기 배제 칼럼 (XK16/69, 슈퍼덱스200pg)에 적재하고, SDS-PAGE에 의해 분석한 후, 쿠마씨 염색 및 항-His 항체를 사용한 이뮤노블롯팅이 이어졌다. 총 단백질은 96-웰 플레이트 포맷 (BCA, 피어스)에 적합화된 브래드포드 검정을 통하여 측정된다. 20 μl의 미지 또는 표준 샘플을 180 μl의 완충제에 희석하였다. 3반복으로 표준에 대하여 (순수 소 혈청 알부민), 또는 미지 샘플에 대하여 일련의 2-배 희석물들을 제조한다. 웰마다 100 μl의 2× 모 브래드포드 시약 (피어스)을 첨가하였다. 다음에, 플레이트를 혼합하고, 마이크로타이터 플레이트 판독기에서 595 nm로 흡광도를 측정하였다. gpUL75에 첨가된 His-태그에 대한 특이적인 항체 (gH, 마우스-항-His, AbD 세로텍) 및 gpUL75 자체에 대한 특이적인 항체 (gH, 마우스-항-gH, 산타 크루즈)의 결합을 조사하는 것에 의해, 크로마토그래피 기반 정제로부터의 상이한 분획에 포함되어 있는 오량체 CMV 복합체를 추가로 분석한다. 이에 따라, 상이한 샘플들을 96-웰 사전-흡수 ELISA 플레이트에서 100 μl/웰의 코팅 완충제 (0.1 M Na₂HPO₄, pH 9) 중에 1:10으로 희석한 후, 4℃에서 밤새 인큐베이션하였다. 이후, 195 μl/웰의 세척 완충제 (1×PBS, 0.05% 트윈20)를 사용하여 플레이트를 3회 세척한 후, 이어서 195 μl/웰의 1× PBS 용액 중 3% BSA를 사용하여 실온에서 1시간 차단하였다. 3회 세척 단계 후, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중 1 ㎍/ml의 농도로 특이적 항체인 항-His 항체 (항-His)는 물론, 항-gpUL75 (항-gH)를 첨가하고 (100 μl/웰), 실온에서 1시간 동안 인큐베이션한 후, 추가적인 3회 세척 단계가 이어졌다. 검출을 위하여, 적절한 이차 항체 (항-마우스-IgG-HRP, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중에 1:1000 희석)를 사용한 1시간 인큐베이션을 수행하였다. 100 μl/웰의 TMP 기질 시약 (미국 샌디에고 소재 BD 바이오사이언시스; 제조자의 프로토콜에 따름)을 사용하여 오량체 복합체에 대한 특이적 항체의 결합을 검출하였는데, 이를 위하여 3-15분 후 100 μl의 1 M HCl을 사용하여 반응을 중지하고, 이어서 마이크로플레이트 판독기에서 450 nm로 OD를 측정하였다.

실시예 7: 전자 현미경법에 의한 생성 조립체의 시각적 확인

정제된 VLP의 형상을 확인하기 위하여, 전자 현미경법을 수행하였다. 10 μl의 VLP 샘플 액적을 구리 피복 EM 격자(grid) 상에서 10분 인큐베이션한 후, 5 μl의 인 텅스텐산을 사용하여 5-10분 동안 염색하고, 물을 사용하여 1분 동안 2회 탈색하였다. 와트만(Whatman) 페이퍼를 사용하여 격자 상 액체를 제거하고, JEOL3000 현미경으로 격자를 옮긴 후, 채취된 입자를 조사 및 사진촬영하였다.

실시예 8: 샌드위치 ELISA의 사용에 의한 결합 검정

상이한 reVLP들 (재조합 VLP들)의 표면 단백질의 존재 및 접근성을 확인하기 위하여, 결합 검정으로서의 샌드위치 ELISA를 수행하였다. 이에 따라, 특이적 표면 및/또는 외피 항체를 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중 1 ㎍/ml의 농도로 96-웰 사전-흡수 ELISA 플레이트 중 코팅 완충제 (0.1 M Na₂HPO₄, pH 9)에 첨가한 후 (100 μl/웰), 4℃에서 밤새 인큐베이션하였다. 이후, 195 μl/웰의 세척 완충제 (1×PBS, 0.05% 트윈20)를 사용하여 플레이트를 3회 세척한 후, 이어서 195 μl/웰의 1× PBS 용액 중 3% BSA를 사용하여 실온에서 1시간 차단하였다. 3회 세척 단계 후, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중 1:10으로 희석된 상이한 VLP들을 첨가하고 (100 μl/웰), 실온에서 1시간 동안 인큐베이션하였다. 3회 세척 단계 후, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중 1 ㎍/ml의 농도로 특이적 항체인 항-표면 항체 (항-gH, 항-gB)는 물론, 항-외피 항체 (항-UL83)를 첨가하고 (100 μl/웰), 실온에서 1시간 동안 인큐베이션한 후, 추가적인 3회 세척 단계가 이어졌다. 검출을 위하여, 적절한 이차 항체 (항-마우스-IgG-HRP, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중에 1:1000 희석)를 사용한 1시간 인큐베이션을 수행하였다. 100 μl/웰의 TMP 기질 시약 (미국 샌디에고 소재 BD 바이오사이언시스; 제조자의 프로토콜에 따름)을 사용하여 VLP에 대한 특이적 항체의 결합을 검출하였다. 3-15분 후 100 μl의 1 M HCl을 사용하여 반응을 중지하고, 이어서 마이크로플레이트 판독기에서 450 nm로 OD를 측정하였다.

실시예 9: 마우스에서의 생체내 연구

생체내 연구를 위하여, 프라임-부스트-부스트 요법으로 Balb/C 마우스를 사용하였다. 각 군은 8마리의 마우스를 포함하였으며, 각 마우스는 주사 당 20 ㎍의 단백질을 투여받았다. 조합 (CMV-reVLP + 오량체 복합체)의 경우, 총량 40 ㎍의 단백질을 주사하였다. 마우스 격리 14일 후 (0일차), 면역-전 혈청을 채취하였다. 10일 후 1차 주사를 수행하고, 42일차에 부스터 주사가 이어졌다. 49일차에 첫 번째 채혈을 수행하였다. 61일차에 2차 부스터 주사를 수행한 후, 이어서 70일차에 추가로 채혈하였다. 85일차에 최종 채혈을 수행한 후, 이어서 체액성 및 세포성 면역 반응을 조사하였다.

실시예 10: 중화 검정에 기초한 체액성 면역 반응

CMV 음성 및 CMV 양성 인간 혈액 공여자로부터의 혈청과 비교한 실시예 9로부터의 마우스 혈청의 중화 검정에 의해, CMV-reVLP (vRBT-20) 및 오량체 복합체 (서열 59)의 조합을 기재로 하는 백신 후보의 체액성 면역 반응을 조사하였다. 실시예 9로부터의 마우스 혈청의 중화 잠재력을 가시화하기 위하여, 분석상의 이유로 GFP 분자를 보유하는 BAC (세균 인공 염색체)-재구성 VR1814 균주 (fix-EGFP)를 섬유모세포 (MRC-5) 및 상피 (ARPE-19) 세포의 감염에 사용하였다. 2×10⁴ 세포/웰을 96 웰 플레이트의 10% FCS (소 태아 혈청)을 함유하는 RPMI 배지에 접종하였다. 8마리 마우스의 혈청 풀(pool)을 생성시키고, 2-배 연속 희석으로 (1:20 내지 1:2560) 100 μl/웰의 RPMI/FCS 배지에 첨가하였다. 상기 언급된 fix-EGFP VR1814 바이러스를 예비-검정에서 결정되었던 1000 바이러스 분자/웰의 조직 배양 감염 투여량 (TCID)로 첨가하였다. 상기 96 웰 플레이트를 CO₂ 조절 분위기하에 37℃로 8일 동안 인큐베이션하였다. 하기의 파라미터들을 사용하여 플레이트 판독기에서 녹색 세포의 측정을 수행하였다: 형광-필터 (여기 485/20, 방출 530/25), 저부 판독 모드, 시간: 0.1초, 96시간 인큐베이션 후 25회 측정/웰. 중화 효능은 50% 바이러스 감염 억제를 나타낼 수 있는 혈청의 희석률로 측정하였다. 하기의 대조를 수행하였다: 세포 대조 (세포 + PBS), 바이러스 대조 (감염된 세포만), 그리고 인간 혈액 공여자 유래의 5 CMV 양성 및 5 CMV 음성 혈청.

실시예 11: 엘리스폿 데이터 (다중 검정)에 기초한 세포성 면역 반응

생체내 연구 (실시예9) 85일차에, 마우스를 사멸시키고, 10종의 상이한 시토카인들의 분석을 위하여 비장세포를 준비하였다. 비장세포의 재자극을 위하여, CMV-reVLP는 물론, 합성 펩티드들의 혼합물을 사용하였다. 하기의 단백질들을 확인하였다: HIVgag, pUL83, gpUL75, gpUL115, gpUL55, gpUL128, gpUL130 및 gpUL131A. 몇 가지 생물정보공학 알고리즘을 사용하여 각 단백질의 에피토프 예측을 수행하였다. 비장세포의 재자극을 위하여, 각 단백질에 대하여 4종 펩티드의 혼합물을 생성시켰다. HIVgag의 경우, 시중에서 구입가능한 130종 펩티드들의 펩티드 혼합물 (베를린 소재 JPT 사)을 사용하였다. 인비트로젠의 다중 검정 키트에 의해 제조자의 프로토콜에 따라 시토카인 (IFN-감마, IL-1베타, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, gCMSF 및 TNF알파)을 조사하였다.

실시예 12: CMV 양성 혈청에 존재하는 항체의 반응에 기초한 결합 검정

백신의 일부로서의 상이한 CMV VLP 및 가용성 복합체들을 특성화하기 위하여, 샌드위치 ELISA 포맷에서의 이중 결합 검정을 수행하였다. 정제된 단일클론 항체와 HCMV 양성 혈액 공여자의 혈청-혼합물에 존재하는 항체의 조합에 의해, 상이한 reVLP들의 캡시드, 외피 및 표면 단백질의 존재 및 접근성을 조사하였다. 이에 따라, 항-gH, 항-gB, 항-UL83, 항-UL86, 항-UL85, 항-UL130/UL131A, 항-gag, 항-His와 같은 항-CMV 단일클론 항체들을 96 웰 사전-흡수 ELISA 플레이트에서 코팅 완충제 (0.1 0.1 M Na₂HPO₄, pH 9) 중 1 ㎍/ml의 최종 농도로 희석하고 (100 μl/웰), 4℃에서 밤새 인큐베이션하였다. 이후, 195 μl/웰의 세척 완충제 (1×PBS, 0.05% 트윈20)를 사용하여 플레이트를 3회 세척한 후, 이어서 195 μl/웰의 1× PBS 용액 중 3% BSA를 사용하여 실온에서 1시간 차단하였다. 3회 세척 단계 후, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중 1:10으로 희석된 상이한 CMV VLP들 및 가용성 복합체를 첨가하고 (100 μl/웰), 실온에서 1시간 동안 인큐베이션하였다. 3회 세척 단계 후, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중 1:300 희석물로 4종 CMV 양성 인간 혈청들의 혼합물을 첨가하고 (100 μl/웰), 실온에서 1시간 동안 인큐베이션한 후, 추가적인 3회 세척 단계가 이어졌다. 검출을 위하여, 적절한 이차 항체 (항-인간-IgG-HRP, 3% BSA, 1× PBS, 0.05% 트윈20, pH 7 중에 1:1000 희석)를 사용한 1시간 인큐베이션을 수행하였다. 100 μl/웰의 TMP 기질 시약 (미국 샌디에고 소재 BD 바이오사이언시스; 제조자의 프로토콜에 따름)을 사용하여 VLP 및 가용성 복합체로 구성되는 단백질에 대한 인간 혈청에 존재하는 항체들의 결합을 검출하였다. 3-15분 후 100 μl의 1 M HCl을 사용하여 반응을 중지하고, 이어서 마이크로플레이트 판독기에서 450 nm로 OD를 측정하였다. 이와 같은 종류의 샌드위치 검정은 한편으로는 단일클론 항체에 대한 결합, 그리고 다른 한편으로는 CMV 양성 혈청에 존재하는 항체에 대한 결합에 기초하여 CMV VLP 및 가용성 복합체의 완전성을 확인하기 위하여 선택되었다. 혈청 중 인간 항체에 대한 결합은 CMV VLP 및 가용성 복합체 중 단백질들의 접근성을 보여주었다.

실시예 13: CMV 양성 공여자로부터의 혈청을 사용한 상이한 CMV - reVLP 및 가용성 복합체의 특성화

실시예 5에 기술되어 있는 바와 같이 상이한 CMV-reVLP 변이체들을 제조하고, 수크로스 쿠션 기반 초원심분리에 의한 농축에 적용하였다. 25 ml의 세포 배양 상청액을 6 mL의 30% 수크로스 쿠션 (50 mM 트리스, 100 mM NaCl, pH 7.4 중 w/v) 상에 덮고, SW28 로터를 사용하여 20'000 rpm 및 16℃에서 1.5시간 동안 펠렛화하였다. 상기 펠렛을 0.2-0.4 ml의 TN-완충제 (50 mM 트리스, 100 mM NaCl, pH 7.4)에 재현탁하였다. 50 μl의 재현탁된 펠렛을 제조자의 프로토콜에 따라 4-12% 비스-트리스 NuPAGE 겔 (인비트로젠) 상에 적재하고, MOPS 전개 완충제를 사용하여 150 V로 15분 동안, 그리고 180 V로 60분 동안 전개시켰다. 심플리블루 세이프스테인 시약 (인비트로젠)을 사용하여 겔을 밤새 염색하고, 물을 사용하여 탈색하였다. 이뮤노블롯팅을 위하여, 반-건조 장치 (바이오라드)를 사용하여 19V에서 1시간 동안, 단백질을 니트로셀룰로스 막 (바이오라드) 상으로 전달하였다. 5% 비-지방 건조-우유 트리스Cl-트윈20 (0.1%) 용액을 사용하여 30분 동안 비특이적 결합 부위를 차단한 후, 5% 비-지방-건조-우유 트리스Cl-트윈20 (0.1%)과 1:500으로 희석된 마우스로부터의 혈청 (군 당 8마리 마우스의 풀) 또는 실시예 10에서 언급된 인간 혈액 공여자로부터의 혈청 중 어느 하나를 사용하여 4℃에서 밤새 막을 인큐베이션하였다. 단백질 검출은 알칼라인-포스파타제 커플링된 이차 항-마우스 항체 (셀 시그널링)를 사용한 인큐베이션 후, NBT/BCIP (써모피셔) 용액을 사용하여 수행하였다.

SEQUENCE LISTING <110> Redbiotec AG <120> Recombinant particle based vaccines against human cytomegalovirus infection <130> P2416PC00 <150> EP12190652.3 <151> 2012-10-30 <160> 91 <170> PatentIn version 3.5 <210> 1 <211> 7353 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 1 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgccac cgctgagcaa taactatcat aacccctagg agatccgaac cagataagtg 7200 aaatctagtt ccaaactatt ttgtcatttt taattttcgt attagcttac gacgctacac 7260 ccagttccca tctattttgt cactcttccc taaataatcc ttaaaaactc catttccacc 7320 cctcccagtt cccaactatt ttgtccgccc aca 7353 <210> 2 <211> 12270 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 2 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaccg gaatattaat 7200 agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt 7260 tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac 7320 catcgggcgc ggatcccggt ccgaagcgcg cggaattcaa aggcctacgt cgacgccacc 7380 atggaatccc gtggtcgtcg ttgccccgag atgatctccg tgctgggtcc catctccggt 7440 cacgtcctga aggctgtgtt ctcccgtggc gacacccccg tgctgcccca cgaaactcgt 7500 ctgctgcaga ccggtatcca cgtgcgtgtg tcccagccct ccctgatcct ggtgtcccag 7560 tacacccccg actccacccc ttgccaccgc ggagacaacc agctgcaggt ccagcacacc 7620 tacttcaccg gttccgaggt cgagaacgtg tccgtgaacg tgcacaaccc caccggtcgt 7680 tccatctgcc cctcccaaga gcccatgtcc atctacgtgt acgctctgcc cctgaagatg 7740 ctgaacatcc cctccatcaa cgtgcaccac tacccctccg ctgctgagcg caagcaccgt 7800 cacctccccg tggctgacgc tgtgatccac gcttccggca agcagatgtg gcaggctcgt 7860 ctgaccgtgt ccggcctggc ttggacccgt cagcagaacc agtggaagga acccgacgtg 7920 tactacacct ccgctttcgt gttccccacc aaggacgtgg ccctgcgtca cgtcgtgtgc 7980 gctcacgaac tcgtgtgctc catggaaaac acccgtgcta ccaagatgca agtgatcggc 8040 gaccagtacg tgaaggtgta cctggaatcc ttctgcgagg acgtgccctc cggcaagctg 8100 ttcatgcacg tgaccctggg ttccgacgtg gaagaggacc tgaccatgac ccgtaacccc 8160 cagcccttca tgcgtcccca cgagcgtaac ggtttcaccg tgctgtgccc caagaacatg 8220 atcatcaagc ccggcaagat ctcccacatc atgctggacg tggccttcac ctcccacgag 8280 cacttcggcc tgctgtgccc taagtccatc cccggcctgt ccatctccgg caacctgctg 8340 atgaacggcc agcagatctt cctggaagtg caggctatcc gtgaaaccgt cgagctgcgt 8400 cagtacgacc ctgtggctgc tctgttcttc ttcgacatcg acctgctgct gcagcgtggt 8460 ccccagtact ccgagcaccc caccttcacc agccagtacc gtatccaggg caagctggaa 8520 taccgtcaca cctgggaccg tcacgacgag ggtgctgctc agggcgacga cgacgtgtgg 8580 acctccggtt ccgactccga cgaggaactg gtcaccaccg agcgcaagac cccccgtgtg 8640 accggtggtg gtgctatggc tggtgcttcc acctccgctg gtcgcaagcg caagtccgct 8700 tcctccgcta ccgcttgcac cgctggtgtc atgacccgtg gtcgcctgaa ggctgagtcc 8760 accgtggctc ccgaagagga cactgacgag gactccgaca acgagatcca caaccccgct 8820 gtgttcacct ggcccccctg gcaggctggt atcctggctc gtaacctggt gcccatggtg 8880 gctaccgtgc agggccagaa cctgaagtac caagagttct tctgggacgc caacgacatc 8940 taccgtatct tcgctgagct ggaaggcgtg tggcagcccg ctgctcagcc caagcgtcgt 9000 cgtcaccgtc aggacgctct gcctggtccc tgtatcgctt ccacccccaa gaagcaccgc 9060 ggctaaaagc ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag 9120 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 9180 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 9240 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 9300 ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc 9360 tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactatc 9420 ataacccccg gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat 9480 aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg 9540 gattattcat accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcgc 9600 caccatgacc atggacgagc agcagcccca ggctgtgacc cccgtgtacg tgggcggttt 9660 cctggctcgt tacgaccagt cccccgacga ggctgagctg ctgctgccac gtgacgtggt 9720 cgaacactgg ctgcacgctc agggccaggg acagccttcc ctgtccgtgg ctctgcccct 9780 gaacatcaac cacgacgaca ccgctgtcgt gggtcacgtg gccgctatgc agtccgtgcg 9840 tgacggcctg ttctgcctgg gttgcgtgac ctccccccgt ttcctggaaa tcgtgcgtcg 9900 tgcttccgag aagtccgagc tggtgtcccg tggtcccgtg tccccactgc agcccgacaa 9960 ggtggtcgag ttcctgtccg gttcctacgc tggcctgtcc ctgtcatccc gtcgttgcga 10020 cgacgtcgag gctgctacct ccctgagcgg ctccgagact acccccttca agcacgtggc 10080 cctgtgctcc gtgggtcgta ggcgtggaac cctggctgtg tacggtcgtg accccgagtg 10140 ggtcacccag cgtttccccg acctgaccgc tgctgaccgt gacggactgc gtgctcagtg 10200 gcagcgttgc ggttccaccg ctgtggacgc ttccggcgac cccttccgtt ccgactccta 10260 cggcctgctg ggcaactccg tggacgctct gtacatccgc gagcgtctgc ccaagctgcg 10320 ttacgacaag cagctcgtgg gtgtcaccga gcgcgagtcc tacgtgaagg cttccgtgtc 10380 ccccgaggct gcttgcgaca tcaaggctgc ttccgctgag cgttctggcg acagccgctc 10440 ccaggctgct actcctgctg ctggtgctcg tgtgccctcc agctccccat ccccacctgt 10500 cgagcctccc tcccccgtgc aacctcctgc tctgcctgct tccccctccg tgctgcctgc 10560 tgagtccagc ccctccctgt caccctctga gcctgctgag gctgcctcca tgtcccaccc 10620 tctgagcgct gctgtgactg ctgctaccgc tccccctggt gctactgtgg ctggtgcttc 10680 ccccgctgtg ccttccctgg cttggcctca cgacggtgtc tacctgccca aggacgcttt 10740 cttctccctg ctgggcgctt cccgttccgc tgctcccgtg atgtaccccg gtgctgtggc 10800 tgctcccccc agcgcttcac ctgctcctct gcccctgccc tcctaccccg cttcctacgg 10860 tgctcccgtc gtgggttacg accagctggc tgctcgtcac ttcgctgact acgtggaccc 10920 ccactacccc ggctggggtc gtcgttacga gcccgctcct tccctgcacc catcctaccc 10980 tgtgccccct cctccatcac ccgcttacta ccgtcgtcgt gactcccccg gtggcatgga 11040 cgagcctcca tctggatggg agcgttacga cggttcccac cgtggccagt cccaaaagca 11100 gcaccgtcac ggtggttccg gtggtcacaa caagcgtcgc aaggaagccg ctgctgcatc 11160 ctccagctcc gacgaggacc tgagcttccc cggcgaggct gaacacggtc gtgctcgcaa 11220 gcgtctgaag tcccacgtga actccgacgg aggtagcgga ggccacgctg gttccaacca 11280 gcagcagcaa cagcgctacg acgagctgcg tgacgctatc cacgagctga agcgtgacct 11340 gttcgctgct cgccagtcct ccaccctgct gtctgctgct ctgccagctg ccgcttcttc 11400 ctcccctacc accaccaccg tgtgcacccc tactggcgag ctgacctctg gtggtggcga 11460 gactcccacc gctctgctgt ccggtggtgc taaggtggcc gagcgtgctc aggctggtgt 11520 cgtgaacgct tcctgccgtc tggctaccgc ttccggttcc gaggctgcca ccgctggtcc 11580 ctctaccgct ggttcctcat cctgcccagc ttccgtggtg ctggctgccg ctgctgctca 11640 agccgccgct gcttcacagt cccccccaaa ggatatggtg gacctgaacc gtcgtatctt 11700 cgtggctgct ctgaacaagc tcgagtaata aaagcttgtc gagaagtact agaggatcat 11760 aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc 11820 cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta 11880 taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact 11940 gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc 12000 actgcttgag cctagaagat ccggctgcta acaaagcccg aaaggaagct gagttggctg 12060 ctgccaccgc tgagcaataa ctatcataac ccctaggaga tccgaaccag ataagtgaaa 12120 tctagttcca aactattttg tcatttttaa ttttcgtatt agcttacgac gctacaccca 12180 gttcccatct attttgtcac tcttccctaa ataatcctta aaaactccat ttccacccct 12240 cccagttccc aactattttg tccgcccaca 12270 <210> 3 <211> 13669 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 3 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaccg gaatattaat 7200 agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt 7260 tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac 7320 catcgggcgc ggatcccggt ccgaagcgcg cggaattcaa aggcctacgt cgacgccacc 7380 atggaatccc gtggtcgtcg ttgccccgag atgatctccg tgctgggtcc catctccggt 7440 cacgtcctga aggctgtgtt ctcccgtggc gacacccccg tgctgcccca cgaaactcgt 7500 ctgctgcaga ccggtatcca cgtgcgtgtg tcccagccct ccctgatcct ggtgtcccag 7560 tacacccccg actccacccc ttgccaccgc ggagacaacc agctgcaggt ccagcacacc 7620 tacttcaccg gttccgaggt cgagaacgtg tccgtgaacg tgcacaaccc caccggtcgt 7680 tccatctgcc cctcccaaga gcccatgtcc atctacgtgt acgctctgcc cctgaagatg 7740 ctgaacatcc cctccatcaa cgtgcaccac tacccctccg ctgctgagcg caagcaccgt 7800 cacctccccg tggctgacgc tgtgatccac gcttccggca agcagatgtg gcaggctcgt 7860 ctgaccgtgt ccggcctggc ttggacccgt cagcagaacc agtggaagga acccgacgtg 7920 tactacacct ccgctttcgt gttccccacc aaggacgtgg ccctgcgtca cgtcgtgtgc 7980 gctcacgaac tcgtgtgctc catggaaaac acccgtgcta ccaagatgca agtgatcggc 8040 gaccagtacg tgaaggtgta cctggaatcc ttctgcgagg acgtgccctc cggcaagctg 8100 ttcatgcacg tgaccctggg ttccgacgtg gaagaggacc tgaccatgac ccgtaacccc 8160 cagcccttca tgcgtcccca cgagcgtaac ggtttcaccg tgctgtgccc caagaacatg 8220 atcatcaagc ccggcaagat ctcccacatc atgctggacg tggccttcac ctcccacgag 8280 cacttcggcc tgctgtgccc taagtccatc cccggcctgt ccatctccgg caacctgctg 8340 atgaacggcc agcagatctt cctggaagtg caggctatcc gtgaaaccgt cgagctgcgt 8400 cagtacgacc ctgtggctgc tctgttcttc ttcgacatcg acctgctgct gcagcgtggt 8460 ccccagtact ccgagcaccc caccttcacc agccagtacc gtatccaggg caagctggaa 8520 taccgtcaca cctgggaccg tcacgacgag ggtgctgctc agggcgacga cgacgtgtgg 8580 acctccggtt ccgactccga cgaggaactg gtcaccaccg agcgcaagac cccccgtgtg 8640 accggtggtg gtgctatggc tggtgcttcc acctccgctg gtcgcaagcg caagtccgct 8700 tcctccgcta ccgcttgcac cgctggtgtc atgacccgtg gtcgcctgaa ggctgagtcc 8760 accgtggctc ccgaagagga cactgacgag gactccgaca acgagatcca caaccccgct 8820 gtgttcacct ggcccccctg gcaggctggt atcctggctc gtaacctggt gcccatggtg 8880 gctaccgtgc agggccagaa cctgaagtac caagagttct tctgggacgc caacgacatc 8940 taccgtatct tcgctgagct ggaaggcgtg tggcagcccg ctgctcagcc caagcgtcgt 9000 cgtcaccgtc aggacgctct gcctggtccc tgtatcgctt ccacccccaa gaagcaccgc 9060 ggctaaaagc ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag 9120 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 9180 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 9240 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 9300 ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc 9360 tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactatc 9420 ataaccggaa tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa 9480 taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat 9540 tattcatacc gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcgccac 9600 catgaccatg gacgagcagc agccccaggc tgtgaccccc gtgtacgtgg gcggtttcct 9660 ggctcgttac gaccagtccc ccgacgaggc tgagctgctg ctgccacgtg acgtggtcga 9720 acactggctg cacgctcagg gccagggaca gccttccctg tccgtggctc tgcccctgaa 9780 catcaaccac gacgacaccg ctgtcgtggg tcacgtggcc gctatgcagt ccgtgcgtga 9840 cggcctgttc tgcctgggtt gcgtgacctc cccccgtttc ctggaaatcg tgcgtcgtgc 9900 ttccgagaag tccgagctgg tgtcccgtgg tcccgtgtcc ccactgcagc ccgacaaggt 9960 ggtcgagttc ctgtccggtt cctacgctgg cctgtccctg tcatcccgtc gttgcgacga 10020 cgtcgaggct gctacctccc tgagcggctc cgagactacc cccttcaagc acgtggccct 10080 gtgctccgtg ggtcgtaggc gtggaaccct ggctgtgtac ggtcgtgacc ccgagtgggt 10140 cacccagcgt ttccccgacc tgaccgctgc tgaccgtgac ggactgcgtg ctcagtggca 10200 gcgttgcggt tccaccgctg tggacgcttc cggcgacccc ttccgttccg actcctacgg 10260 cctgctgggc aactccgtgg acgctctgta catccgcgag cgtctgccca agctgcgtta 10320 cgacaagcag ctcgtgggtg tcaccgagcg cgagtcctac gtgaaggctt ccgtgtcccc 10380 cgaggctgct tgcgacatca aggctgcttc cgctgagcgt tctggcgaca gccgctccca 10440 ggctgctact cctgctgctg gtgctcgtgt gccctccagc tccccatccc cacctgtcga 10500 gcctccctcc cccgtgcaac ctcctgctct gcctgcttcc ccctccgtgc tgcctgctga 10560 gtccagcccc tccctgtcac cctctgagcc tgctgaggct gcctccatgt cccaccctct 10620 gagcgctgct gtgactgctg ctaccgctcc ccctggtgct actgtggctg gtgcttcccc 10680 cgctgtgcct tccctggctt ggcctcacga cggtgtctac ctgcccaagg acgctttctt 10740 ctccctgctg ggcgcttccc gttccgctgc tcccgtgatg taccccggtg ctgtggctgc 10800 tccccccagc gcttcacctg ctcctctgcc cctgccctcc taccccgctt cctacggtgc 10860 tcccgtcgtg ggttacgacc agctggctgc tcgtcacttc gctgactacg tggaccccca 10920 ctaccccggc tggggtcgtc gttacgagcc cgctccttcc ctgcacccat cctaccctgt 10980 gccccctcct ccatcacccg cttactaccg tcgtcgtgac tcccccggtg gcatggacga 11040 gcctccatct ggatgggagc gttacgacgg ttcccaccgt ggccagtccc aaaagcagca 11100 ccgtcacggt ggttccggtg gtcacaacaa gcgtcgcaag gaagccgctg ctgcatcctc 11160 cagctccgac gaggacctga gcttccccgg cgaggctgaa cacggtcgtg ctcgcaagcg 11220 tctgaagtcc cacgtgaact ccgacggagg tagcggaggc cacgctggtt ccaaccagca 11280 gcagcaacag cgctacgacg agctgcgtga cgctatccac gagctgaagc gtgacctgtt 11340 cgctgctcgc cagtcctcca ccctgctgtc tgctgctctg ccagctgccg cttcttcctc 11400 ccctaccacc accaccgtgt gcacccctac tggcgagctg acctctggtg gtggcgagac 11460 tcccaccgct ctgctgtccg gtggtgctaa ggtggccgag cgtgctcagg ctggtgtcgt 11520 gaacgcttcc tgccgtctgg ctaccgcttc cggttccgag gctgccaccg ctggtccctc 11580 taccgctggt tcctcatcct gcccagcttc cgtggtgctg gctgccgctg ctgctcaagc 11640 cgccgctgct tcacagtccc ccccaaagga tatggtggac ctgaaccgtc gtatcttcgt 11700 ggctgctctg aacaagctcg agtaataaaa gcttgtcgag aagtactaga ggatcataat 11760 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 11820 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 11880 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 11940 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 12000 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctggg aatattaata 12060 gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt 12120 cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc 12180 atcgggcgcg gatccgccac catggctgct atggaagcta acatcttctg caccttcgac 12240 cacaagctgt ctatcgctga cgtgggcaag ctgaccaagc tggtggctgc tgtggtgccc 12300 atcccccagc gtctgcacct gatcaagcac taccagctgg gcctgcacca gttcgtggac 12360 cacacccgtg gttacgtgcg tctgcgtggc ctgctgcgta acatgaccct gaccctgatg 12420 cgtcgtgtcg agggcaacca gatcctgctg cacgtgccca cccacggcct gctgtacacc 12480 gtgctgaaca ccggtcccgt gacctgggag aagggcgacg ctctgtgcgt gctgcccccc 12540 ctgttccacg gtcccctggc tcgtgaaaac ctgttgaccc tgggccagtg ggagctggtg 12600 ctgccctgga tcgtgcccat gcccctggct ctggaaatca accagcgcct gctgatcatg 12660 ggcctgttct ccctggaccg ttcctacgaa gaagtgaagg ctgctgtcca gcagctgcag 12720 accatcacct tccgtgacgc taccttcacc atccccgacc ccgtgatcga ccagcacctc 12780 ctgatcgaca tgaagaccgc ttgcctgtcc atgtccatgg tggctaacct ggcttccgag 12840 ctgaccatga cctacgtccg caagctggct ttggaggact cttccatgct gctggtcaag 12900 tgccaagagc tgctgatgcg tctggaccgc gagcgttccg tgggcgagcc tcgtactccc 12960 gctcgtcctc agcacgtgtc ccccgacgac gagatcgctc gtctgtccgc tctgttcgtg 13020 atgctgcgtc agctggacga cctgatccgc gagcaggtcg tgttcaccgt gtgcgacgtg 13080 agcccagaca acaagtccgc tacctgcatc ttcaagggct aaggcgcgcc aagcttgtcg 13140 agaagtacta gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa 13200 aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta 13260 acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa 13320 ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt 13380 atcatgtctg gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga 13440 aaggaagctg agttggctgc tgccaccgct gagcaataac tatcataacc cctaggagat 13500 ccgaaccaga taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta 13560 gcttacgacg ctacacccag ttcccatcta ttttgtcact cttccctaaa taatccttaa 13620 aaactccatt tccacccctc ccagttccca actattttgt ccgcccaca 13669 <210> 4 <211> 12749 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 4 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgccca ccgctgagca ataactatca taacccccgg aatattaata gatcatggag 7200 ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt 7260 ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg 7320 gatccgccac catggctgct atggaagcta acatcttctg caccttcgac cacaagctgt 7380 ctatcgctga cgtgggcaag ctgaccaagc tggtggctgc tgtggtgccc atcccccagc 7440 gtctgcacct gatcaagcac taccagctgg gcctgcacca gttcgtggac cacacccgtg 7500 gttacgtgcg tctgcgtggc ctgctgcgta acatgaccct gaccctgatg cgtcgtgtcg 7560 agggcaacca gatcctgctg cacgtgccca cccacggcct gctgtacacc gtgctgaaca 7620 ccggtcccgt gacctgggag aagggcgacg ctctgtgcgt gctgcccccc ctgttccacg 7680 gtcccctggc tcgtgaaaac ctgttgaccc tgggccagtg ggagctggtg ctgccctgga 7740 tcgtgcccat gcccctggct ctggaaatca accagcgcct gctgatcatg ggcctgttct 7800 ccctggaccg ttcctacgaa gaagtgaagg ctgctgtcca gcagctgcag accatcacct 7860 tccgtgacgc taccttcacc atccccgacc ccgtgatcga ccagcacctc ctgatcgaca 7920 tgaagaccgc ttgcctgtcc atgtccatgg tggctaacct ggcttccgag ctgaccatga 7980 cctacgtccg caagctggct ttggaggact cttccatgct gctggtcaag tgccaagagc 8040 tgctgatgcg tctggaccgc gagcgttccg tgggcgagcc tcgtactccc gctcgtcctc 8100 agcacgtgtc ccccgacgac gagatcgctc gtctgtccgc tctgttcgtg atgctgcgtc 8160 agctggacga cctgatccgc gagcaggtcg tgttcaccgt gtgcgacgtg agcccagaca 8220 acaagtccgc tacctgcatc ttcaagggct aaggcgcgcc aagcttgtcg agaagtacta 8280 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 8340 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 8400 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 8460 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 8520 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 8580 agttggctgc tgccaccgct gagcaataac tatcataacc cccggaatat taatagatca 8640 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 8700 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 8760 gcgcggatcc cggtccgaag cgcgcggaat tcaaaggcct gccaccatgg aaatgaacaa 8820 ggtgctgcat caggatctgg tgcaggctac ccgtcgtatc ctgaagctgg gcccctccga 8880 gctgcgtgtg accgacgctg gcctgatctg caagaacccc aactactccg tgtgcgacgc 8940 tatgctcaag accgacaccg tgtactgcgt cgagtacctg ctgtcctact gggagtcccg 9000 taccgaccac gtgccctgct tcatcttcaa gaacaccggt tgcgctgtgt ccctgtgctg 9060 cttcgtgcgt gctcccgtga agctggtgtc ccctgctcgt cacgtgggcg agttcaacgt 9120 gctgaaggtc aacgagtccc tgatcgtgac cctgaaggac atcgaggaaa tcaagccctc 9180 cgcttacggt gtcctgacta agtgcgtcgt ccgcaagtcc aactccgctt ccgtgttcaa 9240 catcgagctg atcgctttcg gtcccgagaa cgagggcgag tacgagaacc tgctgcgcga 9300 gctgtacgct aagaaggctg cttccacctc cctggctgtg cgtaaccacg tgaccgtgtc 9360 ctcccactcc ggttccggtc cctccctgtg gcgtgctcgt atgtccgctg ctctgacccg 9420 taccgctggc aagcgctcct ccaggactgc tagccctcca ccaccacctc ctcgtcaccc 9480 tagctgctct cccactatgg tggctgctgg tggagctgct gctggtccta gacctccccc 9540 tcctcctatg gctgctggat cctggcgtct gtgccgttgc gaggcttgca tgggccgttg 9600 cggttgcgct tccgagggcg acgctgacga ggaagaggaa gagttgctgg ctctggctgg 9660 cgagggcaag gctgctgctg ccgctgccgg tcaagacgtc ggtggttccg ctcgtcgtcc 9720 cctcgaggaa cacgtgtccc gtcgtcgtgg tgtctccacc caccaccgtc accccccttc 9780 cccaccttgc gctccctccc tggaacgtac cggttaccgt tgggctcctt cctcctggtg 9840 gcgcgctcgt tctggtcctt cccgtcccca gtccggtccc tggctgcctg ctcgtttcgc 9900 taccctgggt cccctggtcc tggctctgct gttggtgctg gccctgctgt ggcgtggtca 9960 cggtcaatcc cccagcccca cccgttccgc tcaccgtgac taaaagcttg tcgagaagta 10020 ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 10080 cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 10140 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 10200 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 10260 ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag 10320 ctgagttggc tgctgtggct agctttgttt aactttaaga aggagataca tctagaaata 10380 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 10440 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 10500 cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcaaaggcc tacgtcgacg 10560 ccaccatgtc caacaccgct cccggtccca ccgtggctaa caagcgtgac gagaagcacc 10620 gtcacgtggt caacgtggtg ctcgagctgc ccaccgagat ctccgaggct acccaccccg 10680 tgctggctac catgctgtcc aagtacaccc gtatgtcctc cctgttcaac gacaagtgcg 10740 ctttcaagct ggacctgctg cgtatggtgg ctgtgtcccg tacccgtcgc taaaagcttg 10800 tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 10860 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 10920 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 10980 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 11040 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 11100 cgaaaggaag ctgagttggc tgctgggtgc ctaatgagtg agctaactca cattaattgc 11160 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 11220 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 11280 cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt cgccaccatg 11340 gacgctcgtg ctgtggctaa gcgtccccgt gaccccgctg acgaggacaa cgagctggtc 11400 accgctctga aggctaagcg tgaagtgaac accatctccg tgcgttacct gtaccacgct 11460 gaccaccagg ctctgaccgc tcgtttcttc gtgcccgagg gcctggtcga gttcgaggct 11520 cagcccggtg ctctgctgat ccgtatggaa accggttgcg actccccccg tcacctgtac 11580 atctccctgt acctgctggg tatccgtgct tccaacgtgt ccgcttccac ccgttgcctg 11640 ctcgagtccg tgtacaccgc ttccgctgct cgtgctgctc tgcagtggct ggacctgggt 11700 ccccacctcc tgcaccgtcg tctggaaacc ctgggttgcg tcaagaccgt gtccctgggt 11760 atcacctccc tgctgacctg cgtgatgcgc ggctacctgt acaacaccct caagaccgag 11820 gtgttcgctc tgatgatccc caaggacatg tacctgacct gggaggaaac ccgcggtcgt 11880 ctgcagtacg tgtacctgat catcgtgtac gactacgacg gtcccgagac tcgtcccggt 11940 atctacgtgc tgacctcctc tatcgctcac tggcagaccc tggtggacgt ggcccgtgga 12000 aagttcgctc gtgaacgctg ctccttcgtg aaccgtcgta tcacccgtcc ccgtcagatc 12060 cccctgtgca ccggtgtcat ccaaaagctg ggctggtgcc tggctgacga catccacacc 12120 tcattcctcg tgcacaagga actgaagctg tccgtcgtgc gtctggacaa cttctccgtc 12180 gagctgggcg acttccgcga gttcgtgtaa aagcttgtcg agaagtacta gaggatcata 12240 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 12300 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 12360 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 12420 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 12480 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 12540 tgccaccgct gagcaataac tatcataacc cctaggagat ccgaaccaga taagtgaaat 12600 ctagttccaa actattttgt catttttaat tttcgtatta gcttacgacg ctacacccag 12660 ttcccatcta ttttgtcact cttccctaaa taatccttaa aaactccatt tccacccctc 12720 ccagttccca actattttgt ccgcccaca 12749 <210> 5 <211> 20067 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 5 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tcacattata cgaagttatc tggtttaaac 2040 gtacccgtag tggctatggc agggcttgcc gccccgacgt tggctgcgag ccctgggcct 2100 tcacccgaac ttgggggttg gggtggggaa aaggaagaaa cgcgggcgta ttggtcccaa 2160 tggggtctcg gtggggtatc gacagagtgc cagccctggg accgaacccc gcgtttatga 2220 acaaacgacc caacacccgt gcgttttatt ctgtcttttt attgccgtca tagcgcgggt 2280 tccttccggt attgtctcct tccgtgtttc agttagcctc ccccatctcc cggtaccgca 2340 tgctatgcat cagctgctag caccatggct cgagatcccg ggtgatcaag tcttcgtcga 2400 gtgattgtaa ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg 2460 ataataattc ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact 2520 agtatcgatt cgcgacctac tccggaatat taatagatca tggagataat taaaatgata 2580 accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac 2640 ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc cggtccgaag 2700 cgcgcggaat tcaaaggcct accgtcgacg ccaccatgga atcccgtggt cgtcgttgcc 2760 ccgagatgat ctccgtgctg ggtcccatct ccggtcacgt cctgaaggct gtgttctccc 2820 gtggcgacac ccccgtgctg ccccacgaaa ctcgtctgct gcagaccggt atccacgtgc 2880 gtgtgtccca gccctccctg atcctggtgt cccagtacac ccccgactcc accccttgcc 2940 accgcggaga caaccagctg caggtccagc acacctactt caccggttcc gaggtcgaga 3000 acgtgtccgt gaacgtgcac aaccccaccg gtcgttccat ctgcccctcc caagagccca 3060 tgtccatcta cgtgtacgct ctgcccctga agatgctgaa catcccctcc atcaacgtgc 3120 accactaccc ctccgctgct gagcgcaagc accgtcacct ccccgtggct gacgctgtga 3180 tccacgcttc cggcaagcag atgtggcagg ctcgtctgac cgtgtccggc ctggcttgga 3240 cccgtcagca gaaccagtgg aaggaacccg acgtgtacta cacctccgct ttcgtgttcc 3300 ccaccaagga cgtggccctg cgtcacgtcg tgtgcgctca cgaactcgtg tgctccatgg 3360 aaaacacccg tgctaccaag atgcaagtga tcggcgacca gtacgtgaag gtgtacctgg 3420 aatccttctg cgaggacgtg ccctccggca agctgttcat gcacgtgacc ctgggttccg 3480 acgtggaaga ggacctgacc atgacccgta acccccagcc cttcatgcgt ccccacgagc 3540 gtaacggttt caccgtgctg tgccccaaga acatgatcat caagcccggc aagatctccc 3600 acatcatgct ggacgtggcc ttcacctccc acgagcactt cggcctgctg tgccctaagt 3660 ccatccccgg cctgtccatc tccggcaacc tgctgatgaa cggccagcag atcttcctgg 3720 aagtgcaggc tatccgtgaa accgtcgagc tgcgtcagta cgaccctgtg gctgctctgt 3780 tcttcttcga catcgacctg ctgctgcagc gtggtcccca gtactccgag caccccacct 3840 tcaccagcca gtaccgtatc cagggcaagc tggaataccg tcacacctgg gaccgtcacg 3900 acgagggtgc tgctcagggc gacgacgacg tgtggacctc cggttccgac tccgacgagg 3960 aactggtcac caccgagcgc aagacccccc gtgtgaccgg tggtggtgct atggctggtg 4020 cttccacctc cgctggtcgc aagcgcaagt ccgcttcctc cgctaccgct tgcaccgctg 4080 gtgtcatgac ccgtggtcgc ctgaaggctg agtccaccgt ggctcccgaa gaggacactg 4140 acgaggactc cgacaacgag atccacaacc ccgctgtgtt cacctggccc ccctggcagg 4200 ctggtatcct ggctcgtaac ctggtgccca tggtggctac cgtgcagggc cagaacctga 4260 agtaccaaga gttcttctgg gacgccaacg acatctaccg tatcttcgct gagctggaag 4320 gcgtgtggca gcccgctgct cagcccaagc gtcgtcgtca ccgtcaggac gctctgcctg 4380 gtccctgtat cgcttccacc cccaagaagc accgcggcta aaagcttgtc gagaagtact 4440 agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc 4500 cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta 4560 ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat 4620 ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct 4680 ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg aaaggaagct 4740 gagttggctg ctgtggctag ctttgtttaa ctttaagaag gagatacatc tagacctgca 4800 ggccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 4860 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 4920 ttcataccgt cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcgccacca 4980 tgaccatgga cgagcagcag ccccaggctg tgacccccgt gtacgtgggc ggtttcctgg 5040 ctcgttacga ccagtccccc gacgaggctg agctgctgct gccacgtgac gtggtcgaac 5100 actggctgca cgctcagggc cagggacagc cttccctgtc cgtggctctg cccctgaaca 5160 tcaaccacga cgacaccgct gtcgtgggtc acgtggccgc tatgcagtcc gtgcgtgacg 5220 gcctgttctg cctgggttgc gtgacctccc cccgtttcct ggaaatcgtg cgtcgtgctt 5280 ccgagaagtc cgagctggtg tcccgtggtc ccgtgtcccc actgcagccc gacaaggtgg 5340 tcgagttcct gtccggttcc tacgctggcc tgtccctgtc atcccgtcgt tgcgacgacg 5400 tcgaggctgc tacctccctg agcggctccg agactacccc cttcaagcac gtggccctgt 5460 gctccgtggg tcgtaggcgt ggaaccctgg ctgtgtacgg tcgtgacccc gagtgggtca 5520 cccagcgttt ccccgacctg accgctgctg accgtgacgg actgcgtgct cagtggcagc 5580 gttgcggttc caccgctgtg gacgcttccg gcgacccctt ccgttccgac tcctacggcc 5640 tgctgggcaa ctccgtggac gctctgtaca tccgcgagcg tctgcccaag ctgcgttacg 5700 acaagcagct cgtgggtgtc accgagcgcg agtcctacgt gaaggcttcc gtgtcccccg 5760 aggctgcttg cgacatcaag gctgcttccg ctgagcgttc tggcgacagc cgctcccagg 5820 ctgctactcc tgctgctggt gctcgtgtgc cctccagctc cccatcccca cctgtcgagc 5880 ctccctcccc cgtgcaacct cctgctctgc ctgcttcccc ctccgtgctg cctgctgagt 5940 ccagcccctc cctgtcaccc tctgagcctg ctgaggctgc ctccatgtcc caccctctga 6000 gcgctgctgt gactgctgct accgctcccc ctggtgctac tgtggctggt gcttcccccg 6060 ctgtgccttc cctggcttgg cctcacgacg gtgtctacct gcccaaggac gctttcttct 6120 ccctgctggg cgcttcccgt tccgctgctc ccgtgatgta ccccggtgct gtggctgctc 6180 cccccagcgc ttcacctgct cctctgcccc tgccctccta ccccgcttcc tacggtgctc 6240 ccgtcgtggg ttacgaccag ctggctgctc gtcacttcgc tgactacgtg gacccccact 6300 accccggctg gggtcgtcgt tacgagcccg ctccttccct gcacccatcc taccctgtgc 6360 cccctcctcc atcacccgct tactaccgtc gtcgtgactc ccccggtggc atggacgagc 6420 ctccatctgg atgggagcgt tacgacggtt cccaccgtgg ccagtcccaa aagcagcacc 6480 gtcacggtgg ttccggtggt cacaacaagc gtcgcaagga agccgctgct gcatcctcca 6540 gctccgacga ggacctgagc ttccccggcg aggctgaaca cggtcgtgct cgcaagcgtc 6600 tgaagtccca cgtgaactcc gacggaggta gcggaggcca cgctggttcc aaccagcagc 6660 agcaacagcg ctacgacgag ctgcgtgacg ctatccacga gctgaagcgt gacctgttcg 6720 ctgctcgcca gtcctccacc ctgctgtctg ctgctctgcc agctgccgct tcttcctccc 6780 ctaccaccac caccgtgtgc acccctactg gcgagctgac ctctggtggt ggcgagactc 6840 ccaccgctct gctgtccggt ggtgctaagg tggccgagcg tgctcaggct ggtgtcgtga 6900 acgcttcctg ccgtctggct accgcttccg gttccgaggc tgccaccgct ggtccctcta 6960 ccgctggttc ctcatcctgc ccagcttccg tggtgctggc tgccgctgct gctcaagccg 7020 ccgctgcttc acagtccccc ccaaaggata tggtggacct gaaccgtcgt atcttcgtgg 7080 ctgctctgaa caagctcgag taataaaagc ttgtcgagaa gtactagagg atcataatca 7140 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 7200 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 7260 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 7320 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 7380 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc 7440 accgctgagc aataactatc ataaccccta ggggcctcta aacgggtctt gaggggtttt 7500 ttgctgaaag gaggaactat atccggatct gaacaggagg gacagctgat agaaacagaa 7560 gccactggag cacctcaaaa acaccatcat acactaaatc agtaagttgg cagcatcacc 7620 cgacgcactt tgcgccgaat aaatacctgt gacggaagat cacttcgcag aataaataaa 7680 tcctggtgtc cctgttgata ccgggaagcc ctgggccaac ttttggcgaa aatgagacgt 7740 tgatcggcac gtaagaggtt ccaactttca ccataatgaa ataagatcac taccgggcgt 7800 attttttgag ttatcgagat tttcaggagc taaggaagct aaaatggaga aaaaaatcac 7860 tggatatacc accgttgata tatcccaatg gcatcgtaaa gaacattttg aggcatttca 7920 gtcagttgct caatgtacct ataaccagac cgttcagctg gatattacgg cctttttaaa 7980 gaccgtaaag aaaaataagc acaagtttta tccggccttt attcacattc ttgcccgcct 8040 gatgaatgct catccggaat tccgtatggc aatgaaagac ggtgagctgg tgatatggga 8100 tagtgttcac ccttgttaca ccgttttcca tgagcaaact gaaacgtttt catcgctctg 8160 gagtgaatac cacgacgatt tccggcagtt tctacacata tattcgcaag atgtggcgtg 8220 ttacggtgaa aacctggcct atttccctaa agggtttatt gagaatatgt ttttcgtctc 8280 agccaatccc tgggtgagtt tcaccagttt tgatttaaac gtggccaata tggacaactt 8340 cttcgccccc gttttcacca tgggcaaata ttatacgcaa ggcgacaagg tgctgatgcc 8400 gctggcgatt caggttcatc atgccgtttg tgatggcttc catgtcggca gaatgcttaa 8460 tgaattacaa cagtactgcg atgagtggca gggcggggcg taattttttt aaggcagtta 8520 ttggtgccct taaacgcctg gttgctacgc ctgaataagt gataataagc ggatgaatgg 8580 cagaaattcg aaagcaaatt cgacccggtc gtcggttcag ggcagggtcg ttaaatagcc 8640 gcttatgtct attgctggtt taccggttta ttgactaccg gaagcagtgt gaccgtgtgc 8700 ttctcaaatg cctgaggcca gtttgctcag gctctccccg tggaggtaat aattgacgat 8760 atgatcattt attctgcctc ccagctgaca ttcatccggg gtcagcaccg tttctgcgga 8820 ctggctttct acgtgttccg cttcctttag cagcccttgc gccctgagtg cttgcggcag 8880 cgtgaagcta attctgtcag ccgttaagtg ttcctgtgtc actcaaaatt gctttgagag 8940 gctctaaggg cttctcagtg cgttacatcc ctggcttgtt gtccacaacc gttaaacctt 9000 aaaagcttta aaagccttat atattctttt ttttcttata aaacttaaaa ccttagaggc 9060 tatttaagtt gctgatttat attaatttta ttgttcaaac atgagagctt agtacgtgaa 9120 acatgagagc ttagtacgtt agccatgaga gcttagtacg ttagccatga gggtttagtt 9180 cgttaaacat gagagcttag tacgttaaac atgagagctt agtacgtgaa acatgagagc 9240 ttagtacgta ctatcaacag gttgaactgc tgatcaacag atcctctacg cggccgcggt 9300 accataactt cgtatagcat acattatacg aagttatctg gtttaaacgt acccgtagtg 9360 gctatggcag ggcttgccgc cccgacgttg gctgcgagcc ctgggccttc acccgaactt 9420 gggggttggg gtggggaaaa ggaagaaacg cgggcgtatt ggtcccaatg gggtctcggt 9480 ggggtatcga cagagtgcca gccctgggac cgaaccccgc gtttatgaac aaacgaccca 9540 acacccgtgc gttttattct gtctttttat tgccgtcata gcgcgggttc cttccggtat 9600 tgtctccttc cgtgtttcag ttagcctccc ccatctcccg gtaccgcatg ctatgcatca 9660 gctgctagca ccatggctcg agatcccggg tgatcaagtc ttccgtcgag tgattgtaaa 9720 taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga taataattct 9780 tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta gtatcgattc 9840 gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca 9900 aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt 9960 ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga aaactggtcc 10020 gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca cgtcaagacc 10080 tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga ccccgagcgt 10140 tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga atgggtgtac 10200 ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga cctgaacaag 10260 ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc cggtgctggc 10320 ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa gtcccccatc 10380 accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac cttcgagggc 10440 accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg tgctctgaag 10500 aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac cctgctgagg 10560 aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct ggctcgtcag 10620 gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa gatgctggct 10680 accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt cctgacccgt 10740 ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac cacctcctcc 10800 ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat catcatgtcc 10860 ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta cggcaacttc 10920 gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct ggctgacttc 10980 aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga ctccctgagc 11040 caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct gggcgaaaag 11100 accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa ggaccccctg 11160 gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc cgaggaccgt 11220 ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa cgctctgccc 11280 accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt cgtggacgct 11340 ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca ggctttcacc 11400 gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg tttccagcaa 11460 gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg ccgcgaggtg 11520 ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta caaggttgga 11580 aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg ccaagagaac 11640 tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc cgacggcctg 11700 gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat gcgcctgcgt 11760 cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac ctcccccaac 11820 taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga cgctttcctg 11880 ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg tcagctgctg 11940 gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc tgacggtgct 12000 ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg cctggtcacc 12060 cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc cctgtccgct 12120 tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca cctccctcgt 12180 aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc taacatcgag 12240 gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc tgacgagccc 12300 ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa ggtgttctac 12360 ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct gaacctcaag 12420 actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc tgctaccgct 12480 gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc cgaggactcc 12540 gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga ggacgtggcc 12600 accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc tgtgcagttc 12660 gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc tcagaggcag 12720 ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg cgtcgtgacc 12780 gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt ctactccaac 12840 cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga gttcccccac 12900 taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga gtaccacaac 12960 tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct gcactccgtg 13020 atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct gcagaccaag 13080 gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt cgaggtggac 13140 atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc catcgtgacc 13200 aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa caccgtggac 13260 atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt ccgcaccgac 13320 atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta ccgccacgat 13380 gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct gctggacacc 13440 gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc tgctaccgtg 13500 cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga cgtgaactac 13560 ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt ggacccctac 13620 gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc tcagaccttc 13680 gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt cctgtacaac 13740 acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg cgctcagtac 13800 ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat cgacgagtac 13860 ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt gtgcgtcgag 13920 ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct gcccatcctg 13980 tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg tgctttcgct 14040 acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct gcagcagtcc 14100 atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat cataatcagc 14160 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 14220 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 14280 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 14340 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 14400 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccca 14460 ccgctgagca ataactatca taacccccgg aatattaata gatcatggag ataattaaaa 14520 tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa 14580 aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac 14640 catggctgct atggaagcta acatcttctg caccttcgac cacaagctgt ctatcgctga 14700 cgtgggcaag ctgaccaagc tggtggctgc tgtggtgccc atcccccagc gtctgcacct 14760 gatcaagcac taccagctgg gcctgcacca gttcgtggac cacacccgtg gttacgtgcg 14820 tctgcgtggc ctgctgcgta acatgaccct gaccctgatg cgtcgtgtcg agggcaacca 14880 gatcctgctg cacgtgccca cccacggcct gctgtacacc gtgctgaaca ccggtcccgt 14940 gacctgggag aagggcgacg ctctgtgcgt gctgcccccc ctgttccacg gtcccctggc 15000 tcgtgaaaac ctgttgaccc tgggccagtg ggagctggtg ctgccctgga tcgtgcccat 15060 gcccctggct ctggaaatca accagcgcct gctgatcatg ggcctgttct ccctggaccg 15120 ttcctacgaa gaagtgaagg ctgctgtcca gcagctgcag accatcacct tccgtgacgc 15180 taccttcacc atccccgacc ccgtgatcga ccagcacctc ctgatcgaca tgaagaccgc 15240 ttgcctgtcc atgtccatgg tggctaacct ggcttccgag ctgaccatga cctacgtccg 15300 caagctggct ttggaggact cttccatgct gctggtcaag tgccaagagc tgctgatgcg 15360 tctggaccgc gagcgttccg tgggcgagcc tcgtactccc gctcgtcctc agcacgtgtc 15420 ccccgacgac gagatcgctc gtctgtccgc tctgttcgtg atgctgcgtc agctggacga 15480 cctgatccgc gagcaggtcg tgttcaccgt gtgcgacgtg agcccagaca acaagtccgc 15540 tacctgcatc ttcaagggct aaggcgcgcc aagcttgtcg agaagtacta gaggatcata 15600 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 15660 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 15720 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 15780 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 15840 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 15900 tgcccaccgc tgagcaataa ctatcataac ccccggaata ttaatagatc atggagataa 15960 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 16020 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 16080 cggtccgaag cgcgcggaat tcaaaggcct acgtcgacgc caccatggaa atgaacaagg 16140 tgctgcatca ggatctggtg caggctaccc gtcgtatcct gaagctgggc ccctccgagc 16200 tgcgtgtgac cgacgctggc ctgatctgca agaaccccaa ctactccgtg tgcgacgcta 16260 tgctcaagac cgacaccgtg tactgcgtcg agtacctgct gtcctactgg gagtcccgta 16320 ccgaccacgt gccctgcttc atcttcaaga acaccggttg cgctgtgtcc ctgtgctgct 16380 tcgtgcgtgc tcccgtgaag ctggtgtccc ctgctcgtca cgtgggcgag ttcaacgtgc 16440 tgaaggtcaa cgagtccctg atcgtgaccc tgaaggacat cgaggaaatc aagccctccg 16500 cttacggtgt cctgactaag tgcgtcgtcc gcaagtccaa ctccgcttcc gtgttcaaca 16560 tcgagctgat cgctttcggt cccgagaacg agggcgagta cgagaacctg ctgcgcgagc 16620 tgtacgctaa gaaggctgct tccacctccc tggctgtgcg taaccacgtg accgtgtcct 16680 cccactccgg ttccggtccc tccctgtggc gtgctcgtat gtccgctgct ctgacccgta 16740 ccgctggcaa gcgctcctcc aggactgcta gccctccacc accacctcct cgtcacccta 16800 gctgctctcc cactatggtg gctgctggtg gagctgctgc tggtcctaga cctccccctc 16860 ctcctatggc tgctggatcc tggcgtctgt gccgttgcga ggcttgcatg ggccgttgcg 16920 gttgcgcttc cgagggcgac gctgacgagg aagaggaaga gttgctggct ctggctggcg 16980 agggcaaggc tgctgctgcc gctgccggtc aagacgtcgg tggttccgct cgtcgtcccc 17040 tcgaggaaca cgtgtcccgt cgtcgtggtg tctccaccca ccaccgtcac cccccttccc 17100 caccttgcgc tccctccctg gaacgtaccg gttaccgttg ggctccttcc tcctggtggc 17160 gcgctcgttc tggtccttcc cgtccccagt ccggtccctg gctgcctgct cgtttcgcta 17220 ccctgggtcc cctggtcctg gctctgctgt tggtgctggc cctgctgtgg cgtggtcacg 17280 gtcaatcccc cagccccacc cgttccgctc accgtgacta aaagcttgtc gagaagtact 17340 agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc 17400 cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta 17460 ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat 17520 ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct 17580 ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg aaaggaagct 17640 gagttggctg ctgtggctag ctttgtttaa ctttaagaag gagatacatc tagaaatatt 17700 aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg 17760 ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc 17820 caccatcggg cgcggatccc ggtccgaagc gcgcggaatt caaaggccta cgtcgacgcc 17880 accatgtcca acaccgctcc cggtcccacc gtggctaaca agcgtgacga gaagcaccgt 17940 cacgtggtca acgtggtgct cgagctgccc accgagatct ccgaggctac ccaccccgtg 18000 ctggctacca tgctgtccaa gtacacccgt atgtcctccc tgttcaacga caagtgcgct 18060 ttcaagctgg acctgctgcg tatggtggct gtgtcccgta cccgtcgcta aaagcttgtc 18120 gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta 18180 aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt 18240 aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca 18300 aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct 18360 tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg 18420 aaaggaagct gagttggctg ctgggtgcct aatgagtgag ctaactcaca ttaattgccc 18480 ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta 18540 ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca 18600 taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattcg ccaccatgga 18660 cgctcgtgct gtggctaagc gtccccgtga ccccgctgac gaggacaacg agctggtcac 18720 cgctctgaag gctaagcgtg aagtgaacac catctccgtg cgttacctgt accacgctga 18780 ccaccaggct ctgaccgctc gtttcttcgt gcccgagggc ctggtcgagt tcgaggctca 18840 gcccggtgct ctgctgatcc gtatggaaac cggttgcgac tccccccgtc acctgtacat 18900 ctccctgtac ctgctgggta tccgtgcttc caacgtgtcc gcttccaccc gttgcctgct 18960 cgagtccgtg tacaccgctt ccgctgctcg tgctgctctg cagtggctgg acctgggtcc 19020 ccacctcctg caccgtcgtc tggaaaccct gggttgcgtc aagaccgtgt ccctgggtat 19080 cacctccctg ctgacctgcg tgatgcgcgg ctacctgtac aacaccctca agaccgaggt 19140 gttcgctctg atgatcccca aggacatgta cctgacctgg gaggaaaccc gcggtcgtct 19200 gcagtacgtg tacctgatca tcgtgtacga ctacgacggt cccgagactc gtcccggtat 19260 ctacgtgctg acctcctcta tcgctcactg gcagaccctg gtggacgtgg cccgtggaaa 19320 gttcgctcgt gaacgctgct ccttcgtgaa ccgtcgtatc acccgtcccc gtcagatccc 19380 cctgtgcacc ggtgtcatcc aaaagctggg ctggtgcctg gctgacgaca tccacacctc 19440 attcctcgtg cacaaggaac tgaagctgtc cgtcgtgcgt ctggacaact tctccgtcga 19500 gctgggcgac ttccgcgagt tcgtgtaaaa gcttgtcgag aagtactaga ggatcataat 19560 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 19620 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 19680 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 19740 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 19800 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 19860 ccaccgctga gcaataacta tcataacccc taggagatcc gaaccagata agtgaaatct 19920 agttccaaac tattttgtca tttttaattt tcgtattagc ttacgacgct acacccagtt 19980 cccatctatt ttgtcactct tccctaaata atccttaaaa actccatttc cacccctccc 20040 agttcccaac tattttgtcc gcccaca 20067 <210> 6 <211> 14134 <212> DNA <213> Artificial <220> <223> Synthetic sequence <400> 6 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttactgcagc caccaccaca gggagttcag ggtggacagg 2400 ttcacagcac gacggtgctc agggggggtc aggttgccgt aggtggagga ctgcaggctg 2460 aagttacgga tctcagacag gaacagcagg gagtccaggt agtcccacat ggggtcgatg 2520 aaggtgcgct ggaaacgggt ggatggggag gtgggggtgg tcttgttgtt gtcggaagca 2580 gtctcgttct cgacgggcat ggtgtcgttg tagtacaggg aggacatgtc cagggtgccg 2640 tagatggtgt agggagtctc gttacggatc agcacgtgag tgttcttcat gaactcggac 2700 acagcggtac ggttacggtt gggcttgcag aagggctcgt cacggtaacg cagggtggtg 2760 tacacccagg tagccaggtc cttcagctga gtggtcagga tagacttcat gaagttctcg 2820 tcgggacggt aaccgatggt agaggtgggg atacgggtgg gcacgatggg ggagtaggtc 2880 acgttggtgg aaacgttgaa gatggtggag gtgtaggagg agtagggggt agtagtgctg 2940 acgcgggact tcttggagat ggacttcacg ggagcctgct tgcgcttcag cttgcgcatg 3000 gtgttcttca gcttggtgga gttgatgtac ttgggcacac ggaagatgtt acgggacata 3060 gcgttgacca ggtagaagga acgggtgcag ttgcgctgag cgtaacgcag cagcagagca 3120 gccaggccca ggaagtagat agtctgggag tccacgttga ccttggaggg gcccacgtac 3180 agcttggtgt tccaacgggg cacgttgaag aacatggggt tgaaggtggt gaagttgccg 3240 cagttttcct cgccggtgtt gttacgacgg gacacgttca gcatctcgga caggcaggtc 3300 atggagggga tggtgccgca agagggggga cggaaggtga tcttctggcc ggtgtggttg 3360 tactcggagt acacgtactt agcgggcttg cgcagctggg tggtgtggaa gtcgaaccac 3420 aggtgggtga tggagtggtt acggatggga ccagccagga tggagttggg ggggaactgc 3480 ttcatctcga cggtgatgtt gtacagcttc tgctggctgg ggaaggtgaa gaacttgtag 3540 tagtcgccgg tcttggaagc cagctcttgc aggatacgca gcttcagctg gcgttcctct 3600 tccttagcct tctgggactt cacacggaaa cgagccacag cgatcttgca gttgatgaag 3660 ctgaacagca ggaaggtcag ggacatcagg aagaacaggt tgaacacgcc acgcatctcg 3720 cccttgcgac ccatggtggc ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 3780 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 3840 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 3900 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 3960 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 4020 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat ggaaaactgg 4080 tccgctctgg aactgctgcc caaggtcgga atccctaccg acttcctgac ccacgtcaag 4140 acctccgctg gcgaggaaat gttcgaggct ctgaggatct actacggcga cgaccccgag 4200 cgttacaaca tccacttcga ggctatcttc ggcaccttct gcaaccgtct ggaatgggtg 4260 tacttcctga cttccggcct ggctgctgct gctcacgcta tcaagttcca cgacctgaac 4320 aagctgacca ccggcaagat gctgttccac gtgcaagtgc cccgtgtggc ttccggtgct 4380 ggcctgccta cctcccgtca gaccaccatc atggtcacca agtactccga gaagtccccc 4440 atcaccatcc ctttcgagct gtccgctgct tgcctgactt acctgcgtga aaccttcgag 4500 ggcaccatcc tggacaagat cctgaacgtc gaggctatgc acaccgtgct gcgtgctctg 4560 aagaacaccg ctgacgctat ggaacgtggc ctgatccaca gcttcctcca gaccctgctg 4620 aggaaggctc ccccctactt cgtggtgcag accctggtcg agaacgctac cctggctcgt 4680 caggctctga accgtatcca gcgctccaac atcctgcagt ccttcaaggc taagatgctg 4740 gctaccctgt tcctgctgaa ccgtacccgt gaccgtgact acgtgctgaa gttcctgacc 4800 cgtctggctg aggctgctac cgactccatc ctcgacaacc ctactaccta caccacctcc 4860 tccggtgcta agatctccgg tgtcatggtg tccaccgcta acgtgatgca gatcatcatg 4920 tccctgctgt cctcccacat cactaaggaa accgtgtccg ctcccgctac ctacggcaac 4980 ttcgtgctgt cccccgagaa cgctgtgacc gctatctcct accactctat cctggctgac 5040 ttcaactcct acaaggctca cctgacctcc ggccagcccc acctccccaa cgactccctg 5100 agccaggctg gtgctcactc cctgaccccc ctgtccatgg acgtgatccg tctgggcgaa 5160 aagaccgtga tcatggaaaa cctgcgtcgc gtgtacaaga acaccgacac caaggacccc 5220 ctggaacgta acgtggacct gaccttcttc ttccccgtgg gcctgtacct gcccgaggac 5280 cgtggttaca ccaccgtcga gtccaaggtc aagctgaacg acaccgtgcg taacgctctg 5340 cccaccaccg cttacctgct gaacagggac cgtgctgtgc aaaagatcga cttcgtggac 5400 gctctcaaga ccctgtgcca ccccgtgctg cacgagcctg ctccatgcct gcaggctttc 5460 accgagcgtg gtcccccatc cgagcccgct atgcagcgtc tgctggaatg ccgtttccag 5520 caagagccca tgggtggtgc tgctcgtcgt atcccccact tctaccgtgt gcgccgcgag 5580 gtgccccgta ccgtgaacga gatgaagcag gacttcgtgg tcaccgactt ctacaaggtt 5640 ggaaacatca ccctgtacac cgagctgcac cctttcttcg acttcaccca ctgccaagag 5700 aactccgaga ctgtggctct gtgcaccccc cgtatcgtga tcggcaacct gcccgacggc 5760 ctggctcccg gtcccttcca cgagctgagg acctgggaga tcatggaaca catgcgcctg 5820 cgtcccccac ccgactacga ggaaaccctg cgtctgttca agaccaccgt gacctccccc 5880 aactaccccg agctgtgcta cctggtggac gtgctggtgc acggcaacgc tgacgctttc 5940 ctgctgatcc gcgctttcat cgctcgttgc atcgtgaaca tgttccacac ccgtcagctg 6000 ctggtgttcg ctcactccta cgctctggtc accctgatcg ctgagcacct ggctgacggt 6060 gctctgcccc cccagctcct gttccactac cgtaacctgg tggctgtgct gcgcctggtc 6120 acccgtatct ccgctctgcc cggcctgaac aacggccagc tggctgagga acccctgtcc 6180 gcttacgtga acgctctgca cgaccacagg ctgtggcccc ccttcgtgac ccacctccct 6240 cgtaacatgg aaggtgtcca ggtggtggct gatcgtcagc ccctgaaccc cgctaacatc 6300 gaggctcgtc accacggtgt ctccgacgtg ccccgtctgg gtgctatgga cgctgacgag 6360 cccctgttcg tggacgacta ccgtgctacc gacgacgagt ggaccctgca aaaggtgttc 6420 tacctgtgcc tgatccccgc tatgaccaac aaccgtgctt gcggcctggg cctgaacctc 6480 aagactctgc tggtggacct gttctaccgt cccgccttcc tgctcatgcc cgctgctacc 6540 gctgtgtcca cctccggcac cacctccaag gaatccacct ctggtgtcac ccccgaggac 6600 tccgtggctg ctcagcgtca ggctgtgggc gagatgctga ccgagctggt cgaggacgtg 6660 gccaccgacg ctcacacccc tctgctgcag gcttgccgcg agctgttcct ggctgtgcag 6720 ttcgtgggcg agcacgtgaa ggtgctggaa gtgcgtgctc ccctggacca cgctcagagg 6780 cagggactgc ccgacttcat ctcccgtcag catgtgctgt acaacggttg ctgcgtcgtg 6840 accgctccta agaccctgat cgagtactcc ctgcccgtgc ccttccaccg tttctactcc 6900 aaccccacca tctgcgctgc tctgtccgac gacatcaagc gttacgtgac cgagttcccc 6960 cactaccata gacacgatgg tggtttcccc ctgcccaccg ctttcgctca cgagtaccac 7020 aactggctgc gtagcccctt ctcccgttac tccgctacct gccccaacgt gctgcactcc 7080 gtgatgaccc tggctgctat gctgtacaag atctcccccg tgtccctggt gctgcagacc 7140 aaggctcaca tccaccccgg tttcgctctg accgctgtgc gtaccgacac cttcgaggtg 7200 gacatgctgc tgtactccgg caagtcctgc acctccgtca tcatcaacaa ccccatcgtg 7260 accaaggaag agagggacat ctccaccacc taccacgtga cccagaacat caacaccgtg 7320 gacatgggcc tgggttacac ctccaacact tgcgtggcct acgtgaaccg cgtccgcacc 7380 gacatgggtg tccgtgtgca ggacctgttc cgtgtgttcc ccatgaacgt gtaccgccac 7440 gatgaggtgg accgttggat caggcacgct gctggcgtcg agcgtcccca gctgctggac 7500 accgagacta tctccatgct gaccttcggt tccatgtccg agcgcaacgc tgctgctacc 7560 gtgcacggcc agaaggctgt ctgcgagctg atcctgaccc ctgtgactat ggacgtgaac 7620 tacttcaaga tcaccaacaa ccctcgtggt cgtgcttcct gcatgctggg cgtggacccc 7680 tacgacaccg aggctgccac caaggctatc tacgaccacc gcgaggctga cgctcagacc 7740 ttcgctgcta cccacaaccc atgggcttcc caggctggtt gcctgtccga cgtcctgtac 7800 aacacccgtc accgcgagcg tctgggctac aactccaagt tctactcccc ctgcgctcag 7860 tacttcaaca ccgaggaaat catcgctgcc aacaagaccc tcttcaagac catcgacgag 7920 tacctgctgc gcgctaagga ctgcatccgt ggcgacaccg acactcagta cgtgtgcgtc 7980 gagggaaccg agcagctgat cgagaaccct tgccgtctga cccaagaggc tctgcccatc 8040 ctgtccacca ccaccctggc tctgatggaa actaagctga agggtggcgc tggtgctttc 8100 gctacctccg agactcactt cggcaactac gtcgtgggag agatcatccc cctgcagcag 8160 tccatgctgt tcaacagcta agagctcaag cttgtcgaga agtactagag gatcataatc 8220 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 8280 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 8340 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 8400 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 8460 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgc 8520 ccaccgctga gcaataacta tcataacccc cggaatatta atagatcatg gagataatta 8580 aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca gttttgtaat 8640 aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc gcggatccgc 8700 caccatggct gctatggaag ctaacatctt ctgcaccttc gaccacaagc tgtctatcgc 8760 tgacgtgggc aagctgacca agctggtggc tgctgtggtg cccatccccc agcgtctgca 8820 cctgatcaag cactaccagc tgggcctgca ccagttcgtg gaccacaccc gtggttacgt 8880 gcgtctgcgt ggcctgctgc gtaacatgac cctgaccctg atgcgtcgtg tcgagggcaa 8940 ccagatcctg ctgcacgtgc ccacccacgg cctgctgtac accgtgctga acaccggtcc 9000 cgtgacctgg gagaagggcg acgctctgtg cgtgctgccc cccctgttcc acggtcccct 9060 ggctcgtgaa aacctgttga ccctgggcca gtgggagctg gtgctgccct ggatcgtgcc 9120 catgcccctg gctctggaaa tcaaccagcg cctgctgatc atgggcctgt tctccctgga 9180 ccgttcctac gaagaagtga aggctgctgt ccagcagctg cagaccatca ccttccgtga 9240 cgctaccttc accatccccg accccgtgat cgaccagcac ctcctgatcg acatgaagac 9300 cgcttgcctg tccatgtcca tggtggctaa cctggcttcc gagctgacca tgacctacgt 9360 ccgcaagctg gctttggagg actcttccat gctgctggtc aagtgccaag agctgctgat 9420 gcgtctggac cgcgagcgtt ccgtgggcga gcctcgtact cccgctcgtc ctcagcacgt 9480 gtcccccgac gacgagatcg ctcgtctgtc cgctctgttc gtgatgctgc gtcagctgga 9540 cgacctgatc cgcgagcagg tcgtgttcac cgtgtgcgac gtgagcccag acaacaagtc 9600 cgctacctgc atcttcaagg gctaaggcgc gccaagcttg tcgagaagta ctagaggatc 9660 ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc 9720 cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct 9780 tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 9840 ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga 9900 tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc 9960 tgctgcccac cgctgagcaa taactatcat aacccccgga atattaatag atcatggaga 10020 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 10080 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 10140 atccggtccg aagcgcgcgg aattcaaagg cctacgtcga cgccaccatg gaaatgaaca 10200 aggtgctgca tcaggatctg gtgcaggcta cccgtcatat cctgaagctg gacccctccg 10260 agctgcgtgt gaccgacgct ggcctgatct gcaagaaccc caactactcc gtgtgcgacg 10320 ctatgctcaa gaccgacacc gtgtactgcg tcgagtacct gctgtcctac tgggagtccc 10380 gtaccgacca cgtgccctgc ttcatcttca agaacaccgg ttgcgctgtg tccctgtgct 10440 gcttcgtgcg tgctcccgtg aagctggtgt cccctgctcg tcacgtgggc gagttcaacg 10500 tgctgaaggt caacgagtcc ctgatcgtga ccctgaagga catcgaggaa atcaagccct 10560 ccgcttacgg tgtcctgact aagtgcgtcg tccgcaagtc caactccgct tccgtgttca 10620 acatcgagct gatcgctttc ggtcccgaga acgagggcga gtacgagaac ctgctgcgcg 10680 agctgtacgc taagaaggct gcttccacct ccctggctgt gcgtaaccac gtgaccgtgt 10740 cctcccactc cggttccggt ccctccctgt ggcgtgctcg tatgtccgct gctctgaccc 10800 gtaccgctgg caagcgctcc tccaggactg ctagccctcc accaccacct cctcgtcacc 10860 ctagctgctc tcccactatg gtggctgctg gtggagctgc tgctggtcct agacctcccc 10920 ctcctcctat ggctgctgga tcctggcgtc tgtgccgttg cgaggcttgc atgggccgtt 10980 gcggttgcgc ttccgagggc gacgctgacg aggaagagga agagttgctg gctctggctg 11040 gcgagggcaa ggctgctgct gccgctgccg gtcaagacgt cggtggttcc gctcgtcgtc 11100 ccctcgagga acacgtgtcc cgtcgtcgtg gtgtctccac ccaccaccgt cacccccctt 11160 ccccaccttg cgctccctcc ctggaacgta ccggttaccg ttgggctcct tcctcctggt 11220 ggcgcgctcg ttctggtcct tcccgtcccc agtccggtcc ctggctgcct gctcgtttcg 11280 ctaccctggg tcccctggtc ctggctctgc tgttggtgct ggccctgctg tggcgtggtc 11340 acggtcaatc ccccagcccc acccgttccg ctcaccgtga ctaaaagctt gtcgagaagt 11400 actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc 11460 tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt 11520 ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag 11580 catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg 11640 tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa 11700 gctgagttgg ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaccg 11760 gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat 11820 tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat 11880 accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcaa aggcctacgt 11940 cgacgccacc atgtccaaca ccgctcccgg tcccaccgtg gctaacaagc gtgacgagaa 12000 gcaccgtcac gtggtcaacg tggtgctcga gctgcccacc gagatctccg aggctaccca 12060 ccccgtgctg gctaccatgc tgtccaagta cacccgtatg tcctccctgt tcaacgacaa 12120 gtgcgctttc aagctggacc tgctgcgtat ggtggctgtg tcccgtaccc gtcgctaaaa 12180 gcttgtcgag aagtactaga ggatcataat cagccatacc acatttgtag aggttttact 12240 tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt 12300 tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa 12360 tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa 12420 tgtatcttat catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca 12480 aagcccgaaa ggaagctgag ttggctgctg ggtgcctaat gagtgagcta actcacatta 12540 attgcccgga atattaatag atcatggaga taattaaaat gataaccatc tcgcaaataa 12600 ataagtattt tactgttttc gtaacagttt tgtaataaaa aaacctataa atattccgga 12660 ttattcatac cgtcccacca tcgggcgcgg atcccggtcc gaagcgcgcg gaattcgcca 12720 ccatggacgc tcgtgctgtg gctaagcgtc cccgtgaccc cgctgacgag gacaacgagc 12780 tggtcaccgc tctgaaggct aagcgtgaag tgaacaccat ctccgtgcgt tacctgtacc 12840 acgctgacca ccaggctctg accgctcgtt tcttcgtgcc cgagggcctg gtcgagttcg 12900 aggctcagcc cggtgctctg ctgatccgta tggaaaccgg ttgcgactcc ccccgtcacc 12960 tgtacatctc cctgtacctg ctgggtatcc gtgcttccaa cgtgtccgct tccacccgtt 13020 gcctgctcga gtccgtgtac accgcttccg ctgctcgtgc tgctctgcag tggctggacc 13080 tgggtcccca cctcctgcac cgtcgtctgg aaaccctggg ttgcgtcaag accgtgtccc 13140 tgggtatcac ctccctgctg acctgcgtga tgcgcggcta cctgtacaac accctcaaga 13200 ccgaggtgtt cgctctgatg atccccaagg acatgtacct gacctgggag gaaacccgcg 13260 gtcgtctgca gtacgtgtac ctgatcatcg tgtacgacta cgacggtccc gagactcgtc 13320 ccggtatcta cgtgctgacc tcctctatcg ctcactggca gaccctggtg gacgtggccc 13380 gtggaaagtt cgctcgtgaa cgctgctcct tcgtgaaccg tcgtatcacc cgtccccgtc 13440 agatccccct gtgcaccggt gtcatccaaa agctgggctg gtgcctggct gacgacatcc 13500 acacctcatt cctcgtgcac aaggaactga agctgtccgt cgtgcgtctg gacaacttct 13560 ccgtcgagct gggcgacttc cgcgagttcg tgtaaaagct tgtcgagaag tactagagga 13620 tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc 13680 tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag 13740 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 13800 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct 13860 gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg 13920 gctgctgcca ccgctgagca ataactatca taacccctag gagatccgaa ccagataagt 13980 gaaatctagt tccaaactat tttgtcattt ttaattttcg tattagctta cgacgctaca 14040 cccagttccc atctattttg tcactcttcc ctaaataatc cttaaaaact ccatttccac 14100 ccctcccagt tcccaactat tttgtccgcc caca 14134 <210> 7 <211> 21442 <212> DNA <213> Artificial <220> <223> Synthetic sequence <400> 7 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tcacattata cgaagttatc tggtttaaac 2040 gtacccgtag tggctatggc agggcttgcc gccccgacgt tggctgcgag ccctgggcct 2100 tcacccgaac ttgggggttg gggtggggaa aaggaagaaa cgcgggcgta ttggtcccaa 2160 tggggtctcg gtggggtatc gacagagtgc cagccctggg accgaacccc gcgtttatga 2220 acaaacgacc caacacccgt gcgttttatt ctgtcttttt attgccgtca tagcgcgggt 2280 tccttccggt attgtctcct tccgtgtttc agttagcctc ccccatctcc cggtaccgca 2340 tgctatgcat cagctgctag caccatggct cgagatcccg ggtgatcaag tcttcgtcga 2400 gtgattgtaa ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg 2460 ataataattc ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact 2520 agtatcgatt cgcgacctac tccggaatat taatagatca tggagataat taaaatgata 2580 accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac 2640 ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc cggtccgaag 2700 cgcgcggaat tcaaaggcct accgtcgacg ccaccatgga atcccgtggt cgtcgttgcc 2760 ccgagatgat ctccgtgctg ggtcccatct ccggtcacgt cctgaaggct gtgttctccc 2820 gtggcgacac ccccgtgctg ccccacgaaa ctcgtctgct gcagaccggt atccacgtgc 2880 gtgtgtccca gccctccctg atcctggtgt cccagtacac ccccgactcc accccttgcc 2940 accgcggaga caaccagctg caggtccagc acacctactt caccggttcc gaggtcgaga 3000 acgtgtccgt gaacgtgcac aaccccaccg gtcgttccat ctgcccctcc caagagccca 3060 tgtccatcta cgtgtacgct ctgcccctga agatgctgaa catcccctcc atcaacgtgc 3120 accactaccc ctccgctgct gagcgcaagc accgtcacct ccccgtggct gacgctgtga 3180 tccacgcttc cggcaagcag atgtggcagg ctcgtctgac cgtgtccggc ctggcttgga 3240 cccgtcagca gaaccagtgg aaggaacccg acgtgtacta cacctccgct ttcgtgttcc 3300 ccaccaagga cgtggccctg cgtcacgtcg tgtgcgctca cgaactcgtg tgctccatgg 3360 aaaacacccg tgctaccaag atgcaagtga tcggcgacca gtacgtgaag gtgtacctgg 3420 aatccttctg cgaggacgtg ccctccggca agctgttcat gcacgtgacc ctgggttccg 3480 acgtggaaga ggacctgacc atgacccgta acccccagcc cttcatgcgt ccccacgagc 3540 gtaacggttt caccgtgctg tgccccaaga acatgatcat caagcccggc aagatctccc 3600 acatcatgct ggacgtggcc ttcacctccc acgagcactt cggcctgctg tgccctaagt 3660 ccatccccgg cctgtccatc tccggcaacc tgctgatgaa cggccagcag atcttcctgg 3720 aagtgcaggc tatccgtgaa accgtcgagc tgcgtcagta cgaccctgtg gctgctctgt 3780 tcttcttcga catcgacctg ctgctgcagc gtggtcccca gtactccgag caccccacct 3840 tcaccagcca gtaccgtatc cagggcaagc tggaataccg tcacacctgg gaccgtcacg 3900 acgagggtgc tgctcagggc gacgacgacg tgtggacctc cggttccgac tccgacgagg 3960 aactggtcac caccgagcgc aagacccccc gtgtgaccgg tggtggtgct atggctggtg 4020 cttccacctc cgctggtcgc aagcgcaagt ccgcttcctc cgctaccgct tgcaccgctg 4080 gtgtcatgac ccgtggtcgc ctgaaggctg agtccaccgt ggctcccgaa gaggacactg 4140 acgaggactc cgacaacgag atccacaacc ccgctgtgtt cacctggccc ccctggcagg 4200 ctggtatcct ggctcgtaac ctggtgccca tggtggctac cgtgcagggc cagaacctga 4260 agtaccaaga gttcttctgg gacgccaacg acatctaccg tatcttcgct gagctggaag 4320 gcgtgtggca gcccgctgct cagcccaagc gtcgtcgtca ccgtcaggac gctctgcctg 4380 gtccctgtat cgcttccacc cccaagaagc accgcggcta aaagcttgtc gagaagtact 4440 agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc 4500 cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta 4560 ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat 4620 ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct 4680 ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg aaaggaagct 4740 gagttggctg ctgtggctag ctttgtttaa ctttaagaag gagatacatc tagacctgca 4800 ggccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 4860 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 4920 ttcataccgt cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcgccacca 4980 tgaccatgga cgagcagcag ccccaggctg tgacccccgt gtacgtgggc ggtttcctgg 5040 ctcgttacga ccagtccccc gacgaggctg agctgctgct gccacgtgac gtggtcgaac 5100 actggctgca cgctcagggc cagggacagc cttccctgtc cgtggctctg cccctgaaca 5160 tcaaccacga cgacaccgct gtcgtgggtc acgtggccgc tatgcagtcc gtgcgtgacg 5220 gcctgttctg cctgggttgc gtgacctccc cccgtttcct ggaaatcgtg cgtcgtgctt 5280 ccgagaagtc cgagctggtg tcccgtggtc ccgtgtcccc actgcagccc gacaaggtgg 5340 tcgagttcct gtccggttcc tacgctggcc tgtccctgtc atcccgtcgt tgcgacgacg 5400 tcgaggctgc tacctccctg agcggctccg agactacccc cttcaagcac gtggccctgt 5460 gctccgtggg tcgtaggcgt ggaaccctgg ctgtgtacgg tcgtgacccc gagtgggtca 5520 cccagcgttt ccccgacctg accgctgctg accgtgacgg actgcgtgct cagtggcagc 5580 gttgcggttc caccgctgtg gacgcttccg gcgacccctt ccgttccgac tcctacggcc 5640 tgctgggcaa ctccgtggac gctctgtaca tccgcgagcg tctgcccaag ctgcgttacg 5700 acaagcagct cgtgggtgtc accgagcgcg agtcctacgt gaaggcttcc gtgtcccccg 5760 aggctgcttg cgacatcaag gctgcttccg ctgagcgttc tggcgacagc cgctcccagg 5820 ctgctactcc tgctgctggt gctcgtgtgc cctccagctc cccatcccca cctgtcgagc 5880 ctccctcccc cgtgcaacct cctgctctgc ctgcttcccc ctccgtgctg cctgctgagt 5940 ccagcccctc cctgtcaccc tctgagcctg ctgaggctgc ctccatgtcc caccctctga 6000 gcgctgctgt gactgctgct accgctcccc ctggtgctac tgtggctggt gcttcccccg 6060 ctgtgccttc cctggcttgg cctcacgacg gtgtctacct gcccaaggac gctttcttct 6120 ccctgctggg cgcttcccgt tccgctgctc ccgtgatgta ccccggtgct gtggctgctc 6180 cccccagcgc ttcacctgct cctctgcccc tgccctccta ccccgcttcc tacggtgctc 6240 ccgtcgtggg ttacgaccag ctggctgctc gtcacttcgc tgactacgtg gacccccact 6300 accccggctg gggtcgtcgt tacgagcccg ctccttccct gcacccatcc taccctgtgc 6360 cccctcctcc atcacccgct tactaccgtc gtcgtgactc ccccggtggc atggacgagc 6420 ctccatctgg atgggagcgt tacgacggtt cccaccgtgg ccagtcccaa aagcagcacc 6480 gtcacggtgg ttccggtggt cacaacaagc gtcgcaagga agccgctgct gcatcctcca 6540 gctccgacga ggacctgagc ttccccggcg aggctgaaca cggtcgtgct cgcaagcgtc 6600 tgaagtccca cgtgaactcc gacggaggta gcggaggcca cgctggttcc aaccagcagc 6660 agcaacagcg ctacgacgag ctgcgtgacg ctatccacga gctgaagcgt gacctgttcg 6720 ctgctcgcca gtcctccacc ctgctgtctg ctgctctgcc agctgccgct tcttcctccc 6780 ctaccaccac caccgtgtgc acccctactg gcgagctgac ctctggtggt ggcgagactc 6840 ccaccgctct gctgtccggt ggtgctaagg tggccgagcg tgctcaggct ggtgtcgtga 6900 acgcttcctg ccgtctggct accgcttccg gttccgaggc tgccaccgct ggtccctcta 6960 ccgctggttc ctcatcctgc ccagcttccg tggtgctggc tgccgctgct gctcaagccg 7020 ccgctgcttc acagtccccc ccaaaggata tggtggacct gaaccgtcgt atcttcgtgg 7080 ctgctctgaa caagctcgag taataaaagc ttgtcgagaa gtactagagg atcataatca 7140 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 7200 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 7260 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 7320 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 7380 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc 7440 accgctgagc aataactatc ataaccccta ggggcctcta aacgggtctt gaggggtttt 7500 ttgctgaaag gaggaactat atccggatct gaacaggagg gacagctgat agaaacagaa 7560 gccactggag cacctcaaaa acaccatcat acactaaatc agtaagttgg cagcatcacc 7620 cgacgcactt tgcgccgaat aaatacctgt gacggaagat cacttcgcag aataaataaa 7680 tcctggtgtc cctgttgata ccgggaagcc ctgggccaac ttttggcgaa aatgagacgt 7740 tgatcggcac gtaagaggtt ccaactttca ccataatgaa ataagatcac taccgggcgt 7800 attttttgag ttatcgagat tttcaggagc taaggaagct aaaatggaga aaaaaatcac 7860 tggatatacc accgttgata tatcccaatg gcatcgtaaa gaacattttg aggcatttca 7920 gtcagttgct caatgtacct ataaccagac cgttcagctg gatattacgg cctttttaaa 7980 gaccgtaaag aaaaataagc acaagtttta tccggccttt attcacattc ttgcccgcct 8040 gatgaatgct catccggaat tccgtatggc aatgaaagac ggtgagctgg tgatatggga 8100 tagtgttcac ccttgttaca ccgttttcca tgagcaaact gaaacgtttt catcgctctg 8160 gagtgaatac cacgacgatt tccggcagtt tctacacata tattcgcaag atgtggcgtg 8220 ttacggtgaa aacctggcct atttccctaa agggtttatt gagaatatgt ttttcgtctc 8280 agccaatccc tgggtgagtt tcaccagttt tgatttaaac gtggccaata tggacaactt 8340 cttcgccccc gttttcacca tgggcaaata ttatacgcaa ggcgacaagg tgctgatgcc 8400 gctggcgatt caggttcatc atgccgtttg tgatggcttc catgtcggca gaatgcttaa 8460 tgaattacaa cagtactgcg atgagtggca gggcggggcg taattttttt aaggcagtta 8520 ttggtgccct taaacgcctg gttgctacgc ctgaataagt gataataagc ggatgaatgg 8580 cagaaattcg aaagcaaatt cgacccggtc gtcggttcag ggcagggtcg ttaaatagcc 8640 gcttatgtct attgctggtt taccggttta ttgactaccg gaagcagtgt gaccgtgtgc 8700 ttctcaaatg cctgaggcca gtttgctcag gctctccccg tggaggtaat aattgacgat 8760 atgatcattt attctgcctc ccagctgaca ttcatccggg gtcagcaccg tttctgcgga 8820 ctggctttct acgtgttccg cttcctttag cagcccttgc gccctgagtg cttgcggcag 8880 cgtgaagcta attctgtcag ccgttaagtg ttcctgtgtc actcaaaatt gctttgagag 8940 gctctaaggg cttctcagtg cgttacatcc ctggcttgtt gtccacaacc gttaaacctt 9000 aaaagcttta aaagccttat atattctttt ttttcttata aaacttaaaa ccttagaggc 9060 tatttaagtt gctgatttat attaatttta ttgttcaaac atgagagctt agtacgtgaa 9120 acatgagagc ttagtacgtt agccatgaga gcttagtacg ttagccatga gggtttagtt 9180 cgttaaacat gagagcttag tacgttaaac atgagagctt agtacgtgaa acatgagagc 9240 ttagtacgta ctatcaacag gttgaactgc tgatcaacag atcctctacg cggccgcggt 9300 accataactt cgtatagcat acattatacg aagttatctg gtttaaacgt acccgtagtg 9360 gctatggcag ggcttgccgc cccgacgttg gctgcgagcc ctgggccttc acccgaactt 9420 gggggttggg gtggggaaaa ggaagaaacg cgggcgtatt ggtcccaatg gggtctcggt 9480 ggggtatcga cagagtgcca gccctgggac cgaaccccgc gtttatgaac aaacgaccca 9540 acacccgtgc gttttattct gtctttttat tgccgtcata gcgcgggttc cttccggtat 9600 tgtctccttc cgtgtttcag ttagcctccc ccatctcccg gtaccgcatg ctatgcatca 9660 gctgctagct tactgcagcc accaccacag ggagttcagg gtggacaggt tcacagcacg 9720 acggtgctca gggggggtca ggttgccgta ggtggaggac tgcaggctga agttacggat 9780 ctcagacagg aacagcaggg agtccaggta gtcccacatg gggtcgatga aggtgcgctg 9840 gaaacgggtg gatggggagg tgggggtggt cttgttgttg tcggaagcag tctcgttctc 9900 gacgggcatg gtgtcgttgt agtacaggga ggacatgtcc agggtgccgt agatggtgta 9960 gggagtctcg ttacggatca gcacgtgagt gttcttcatg aactcggaca cagcggtacg 10020 gttacggttg ggcttgcaga agggctcgtc acggtaacgc agggtggtgt acacccaggt 10080 agccaggtcc ttcagctgag tggtcaggat agacttcatg aagttctcgt cgggacggta 10140 accgatggta gaggtgggga tacgggtggg cacgatgggg gagtaggtca cgttggtgga 10200 aacgttgaag atggtggagg tgtaggagga gtagggggta gtagtgctga cgcgggactt 10260 cttggagatg gacttcacgg gagcctgctt gcgcttcagc ttgcgcatgg tgttcttcag 10320 cttggtggag ttgatgtact tgggcacacg gaagatgtta cgggacatag cgttgaccag 10380 gtagaaggaa cgggtgcagt tgcgctgagc gtaacgcagc agcagagcag ccaggcccag 10440 gaagtagata gtctgggagt ccacgttgac cttggagggg cccacgtaca gcttggtgtt 10500 ccaacggggc acgttgaaga acatggggtt gaaggtggtg aagttgccgc agttttcctc 10560 gccggtgttg ttacgacggg acacgttcag catctcggac aggcaggtca tggaggggat 10620 ggtgccgcaa gaggggggac ggaaggtgat cttctggccg gtgtggttgt actcggagta 10680 cacgtactta gcgggcttgc gcagctgggt ggtgtggaag tcgaaccaca ggtgggtgat 10740 ggagtggtta cggatgggac cagccaggat ggagttgggg gggaactgct tcatctcgac 10800 ggtgatgttg tacagcttct gctggctggg gaaggtgaag aacttgtagt agtcgccggt 10860 cttggaagcc agctcttgca ggatacgcag cttcagctgg cgttcctctt ccttagcctt 10920 ctgggacttc acacggaaac gagccacagc gatcttgcag ttgatgaagc tgaacagcag 10980 gaaggtcagg gacatcagga agaacaggtt gaacacgcca cgcatctcgc ccttgcgacc 11040 catggtggcc tcgaggagat cccgggtgat caagtcttcg tcgagtgatt gtaaataaaa 11100 tgtaatttac agtatagtat tttaattaat atacaaatga tttgataata attcttattt 11160 aactataata tattgtgttg ggttgaatta aaggtccgta tactagtatc gattcgcgac 11220 ctactccgga atattaatag atcatggaga taattaaaat gataaccatc tcgcaaataa 11280 ataagtattt tactgttttc gtaacagttt tgtaataaaa aaacctataa atattccgga 11340 ttattcatac cgtcccacca tcgggcgcgg atccgccacc atggaaaact ggtccgctct 11400 ggaactgctg cccaaggtcg gaatccctac cgacttcctg acccacgtca agacctccgc 11460 tggcgaggaa atgttcgagg ctctgaggat ctactacggc gacgaccccg agcgttacaa 11520 catccacttc gaggctatct tcggcacctt ctgcaaccgt ctggaatggg tgtacttcct 11580 gacttccggc ctggctgctg ctgctcacgc tatcaagttc cacgacctga acaagctgac 11640 caccggcaag atgctgttcc acgtgcaagt gccccgtgtg gcttccggtg ctggcctgcc 11700 tacctcccgt cagaccacca tcatggtcac caagtactcc gagaagtccc ccatcaccat 11760 ccctttcgag ctgtccgctg cttgcctgac ttacctgcgt gaaaccttcg agggcaccat 11820 cctggacaag atcctgaacg tcgaggctat gcacaccgtg ctgcgtgctc tgaagaacac 11880 cgctgacgct atggaacgtg gcctgatcca cagcttcctc cagaccctgc tgaggaaggc 11940 tcccccctac ttcgtggtgc agaccctggt cgagaacgct accctggctc gtcaggctct 12000 gaaccgtatc cagcgctcca acatcctgca gtccttcaag gctaagatgc tggctaccct 12060 gttcctgctg aaccgtaccc gtgaccgtga ctacgtgctg aagttcctga cccgtctggc 12120 tgaggctgct accgactcca tcctcgacaa ccctactacc tacaccacct cctccggtgc 12180 taagatctcc ggtgtcatgg tgtccaccgc taacgtgatg cagatcatca tgtccctgct 12240 gtcctcccac atcactaagg aaaccgtgtc cgctcccgct acctacggca acttcgtgct 12300 gtcccccgag aacgctgtga ccgctatctc ctaccactct atcctggctg acttcaactc 12360 ctacaaggct cacctgacct ccggccagcc ccacctcccc aacgactccc tgagccaggc 12420 tggtgctcac tccctgaccc ccctgtccat ggacgtgatc cgtctgggcg aaaagaccgt 12480 gatcatggaa aacctgcgtc gcgtgtacaa gaacaccgac accaaggacc ccctggaacg 12540 taacgtggac ctgaccttct tcttccccgt gggcctgtac ctgcccgagg accgtggtta 12600 caccaccgtc gagtccaagg tcaagctgaa cgacaccgtg cgtaacgctc tgcccaccac 12660 cgcttacctg ctgaacaggg accgtgctgt gcaaaagatc gacttcgtgg acgctctcaa 12720 gaccctgtgc caccccgtgc tgcacgagcc tgctccatgc ctgcaggctt tcaccgagcg 12780 tggtccccca tccgagcccg ctatgcagcg tctgctggaa tgccgtttcc agcaagagcc 12840 catgggtggt gctgctcgtc gtatccccca cttctaccgt gtgcgccgcg aggtgccccg 12900 taccgtgaac gagatgaagc aggacttcgt ggtcaccgac ttctacaagg ttggaaacat 12960 caccctgtac accgagctgc accctttctt cgacttcacc cactgccaag agaactccga 13020 gactgtggct ctgtgcaccc cccgtatcgt gatcggcaac ctgcccgacg gcctggctcc 13080 cggtcccttc cacgagctga ggacctggga gatcatggaa cacatgcgcc tgcgtccccc 13140 acccgactac gaggaaaccc tgcgtctgtt caagaccacc gtgacctccc ccaactaccc 13200 cgagctgtgc tacctggtgg acgtgctggt gcacggcaac gctgacgctt tcctgctgat 13260 ccgcgctttc atcgctcgtt gcatcgtgaa catgttccac acccgtcagc tgctggtgtt 13320 cgctcactcc tacgctctgg tcaccctgat cgctgagcac ctggctgacg gtgctctgcc 13380 cccccagctc ctgttccact accgtaacct ggtggctgtg ctgcgcctgg tcacccgtat 13440 ctccgctctg cccggcctga acaacggcca gctggctgag gaacccctgt ccgcttacgt 13500 gaacgctctg cacgaccaca ggctgtggcc ccccttcgtg acccacctcc ctcgtaacat 13560 ggaaggtgtc caggtggtgg ctgatcgtca gcccctgaac cccgctaaca tcgaggctcg 13620 tcaccacggt gtctccgacg tgccccgtct gggtgctatg gacgctgacg agcccctgtt 13680 cgtggacgac taccgtgcta ccgacgacga gtggaccctg caaaaggtgt tctacctgtg 13740 cctgatcccc gctatgacca acaaccgtgc ttgcggcctg ggcctgaacc tcaagactct 13800 gctggtggac ctgttctacc gtcccgcctt cctgctcatg cccgctgcta ccgctgtgtc 13860 cacctccggc accacctcca aggaatccac ctctggtgtc acccccgagg actccgtggc 13920 tgctcagcgt caggctgtgg gcgagatgct gaccgagctg gtcgaggacg tggccaccga 13980 cgctcacacc cctctgctgc aggcttgccg cgagctgttc ctggctgtgc agttcgtggg 14040 cgagcacgtg aaggtgctgg aagtgcgtgc tcccctggac cacgctcaga ggcagggact 14100 gcccgacttc atctcccgtc agcatgtgct gtacaacggt tgctgcgtcg tgaccgctcc 14160 taagaccctg atcgagtact ccctgcccgt gcccttccac cgtttctact ccaaccccac 14220 catctgcgct gctctgtccg acgacatcaa gcgttacgtg accgagttcc cccactacca 14280 tagacacgat ggtggtttcc ccctgcccac cgctttcgct cacgagtacc acaactggct 14340 gcgtagcccc ttctcccgtt actccgctac ctgccccaac gtgctgcact ccgtgatgac 14400 cctggctgct atgctgtaca agatctcccc cgtgtccctg gtgctgcaga ccaaggctca 14460 catccacccc ggtttcgctc tgaccgctgt gcgtaccgac accttcgagg tggacatgct 14520 gctgtactcc ggcaagtcct gcacctccgt catcatcaac aaccccatcg tgaccaagga 14580 agagagggac atctccacca cctaccacgt gacccagaac atcaacaccg tggacatggg 14640 cctgggttac acctccaaca cttgcgtggc ctacgtgaac cgcgtccgca ccgacatggg 14700 tgtccgtgtg caggacctgt tccgtgtgtt ccccatgaac gtgtaccgcc acgatgaggt 14760 ggaccgttgg atcaggcacg ctgctggcgt cgagcgtccc cagctgctgg acaccgagac 14820 tatctccatg ctgaccttcg gttccatgtc cgagcgcaac gctgctgcta ccgtgcacgg 14880 ccagaaggct gtctgcgagc tgatcctgac ccctgtgact atggacgtga actacttcaa 14940 gatcaccaac aaccctcgtg gtcgtgcttc ctgcatgctg ggcgtggacc cctacgacac 15000 cgaggctgcc accaaggcta tctacgacca ccgcgaggct gacgctcaga ccttcgctgc 15060 tacccacaac ccatgggctt cccaggctgg ttgcctgtcc gacgtcctgt acaacacccg 15120 tcaccgcgag cgtctgggct acaactccaa gttctactcc ccctgcgctc agtacttcaa 15180 caccgaggaa atcatcgctg ccaacaagac cctcttcaag accatcgacg agtacctgct 15240 gcgcgctaag gactgcatcc gtggcgacac cgacactcag tacgtgtgcg tcgagggaac 15300 cgagcagctg atcgagaacc cttgccgtct gacccaagag gctctgccca tcctgtccac 15360 caccaccctg gctctgatgg aaactaagct gaagggtggc gctggtgctt tcgctacctc 15420 cgagactcac ttcggcaact acgtcgtggg agagatcatc cccctgcagc agtccatgct 15480 gttcaacagc taagagctca agcttgtcga gaagtactag aggatcataa tcagccatac 15540 cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa 15600 acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa 15660 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 15720 tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac tgcttgagcc 15780 tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct gcccaccgct 15840 gagcaataac tatcataacc cccggaatat taatagatca tggagataat taaaatgata 15900 accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac 15960 ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgg 16020 ctgctatgga agctaacatc ttctgcacct tcgaccacaa gctgtctatc gctgacgtgg 16080 gcaagctgac caagctggtg gctgctgtgg tgcccatccc ccagcgtctg cacctgatca 16140 agcactacca gctgggcctg caccagttcg tggaccacac ccgtggttac gtgcgtctgc 16200 gtggcctgct gcgtaacatg accctgaccc tgatgcgtcg tgtcgagggc aaccagatcc 16260 tgctgcacgt gcccacccac ggcctgctgt acaccgtgct gaacaccggt cccgtgacct 16320 gggagaaggg cgacgctctg tgcgtgctgc cccccctgtt ccacggtccc ctggctcgtg 16380 aaaacctgtt gaccctgggc cagtgggagc tggtgctgcc ctggatcgtg cccatgcccc 16440 tggctctgga aatcaaccag cgcctgctga tcatgggcct gttctccctg gaccgttcct 16500 acgaagaagt gaaggctgct gtccagcagc tgcagaccat caccttccgt gacgctacct 16560 tcaccatccc cgaccccgtg atcgaccagc acctcctgat cgacatgaag accgcttgcc 16620 tgtccatgtc catggtggct aacctggctt ccgagctgac catgacctac gtccgcaagc 16680 tggctttgga ggactcttcc atgctgctgg tcaagtgcca agagctgctg atgcgtctgg 16740 accgcgagcg ttccgtgggc gagcctcgta ctcccgctcg tcctcagcac gtgtcccccg 16800 acgacgagat cgctcgtctg tccgctctgt tcgtgatgct gcgtcagctg gacgacctga 16860 tccgcgagca ggtcgtgttc accgtgtgcg acgtgagccc agacaacaag tccgctacct 16920 gcatcttcaa gggctaaggc gcgccaagct tgtcgagaag tactagagga tcataatcag 16980 ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa 17040 cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg 17100 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 17160 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct gatcactgct 17220 tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg gctgctgccc 17280 accgctgagc aataactatc ataacccccg gaatattaat agatcatgga gataattaaa 17340 atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt tttgtaataa 17400 aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc ggatccggtc 17460 cgaagcgcgc ggaattcaaa ggcctacgtc gacgccacca tggaaatgaa caaggtgctg 17520 catcaggatc tggtgcaggc tacccgtcgt atcctgaagc tgggcccctc cgagctgcgt 17580 gtgaccgacg ctggcctgat ctgcaagaac cccaactact ccgtgtgcga cgctatgctc 17640 aagaccgaca ccgtgtactg cgtcgagtac ctgctgtcct actgggagtc ccgtaccgac 17700 cacgtgccct gcttcatctt caagaacacc ggttgcgctg tgtccctgtg ctgcttcgtg 17760 cgtgctcccg tgaagctggt gtcccctgct cgtcacgtgg gcgagttcaa cgtgctgaag 17820 gtcaacgagt ccctgatcgt gaccctgaag gacatcgagg aaatcaagcc ctccgcttac 17880 ggtgtcctga ctaagtgcgt cgtccgcaag tccaactccg cttccgtgtt caacatcgag 17940 ctgatcgctt tcggtcccga gaacgagggc gagtacgaga acctgctgcg cgagctgtac 18000 gctaagaagg ctgcttccac ctccctggct gtgcgtaacc acgtgaccgt gtcctcccac 18060 tccggttccg gtccctccct gtggcgtgct cgtatgtccg ctgctctgac ccgtaccgct 18120 ggcaagcgct cctccaggac tgctagccct ccaccaccac ctcctcgtca ccctagctgc 18180 tctcccacta tggtggctgc tggtggagct gctgctggtc ctagacctcc ccctcctcct 18240 atggctgctg gatcctggcg tctgtgccgt tgcgaggctt gcatgggccg ttgcggttgc 18300 gcttccgagg gcgacgctga cgaggaagag gaagagttgc tggctctggc tggcgagggc 18360 aaggctgctg ctgccgctgc cggtcaagac gtcggtggtt ccgctcgtcg tcccctcgag 18420 gaacacgtgt cccgtcgtcg tggtgtctcc acccaccacc gtcacccccc ttccccacct 18480 tgcgctccct ccctggaacg taccggttac cgttgggctc cttcctcctg gtggcgcgct 18540 cgttctggtc cttcccgtcc ccagtccggt ccctggctgc ctgctcgttt cgctaccctg 18600 ggtcccctgg tcctggctct gctgttggtg ctggccctgc tgtggcgtgg tcacggtcaa 18660 tcccccagcc ccacccgttc cgctcaccgt gactaaaagc ttgtcgagaa gtactagagg 18720 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 18780 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 18840 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 18900 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 18960 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 19020 ggctgctgtg gctagctttg tttaacttta agaaggagat acatctagaa atattaatag 19080 atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc 19140 gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca 19200 tcgggcgcgg atcccggtcc gaagcgcgcg gaattcaaag gcctacgtcg acgccaccat 19260 gtccaacacc gctcccggtc ccaccgtggc taacaagcgt gacgagaagc accgtcacgt 19320 ggtcaacgtg gtgctcgagc tgcccaccga gatctccgag gctacccacc ccgtgctggc 19380 taccatgctg tccaagtaca cccgtatgtc ctccctgttc aacgacaagt gcgctttcaa 19440 gctggacctg ctgcgtatgg tggctgtgtc ccgtacccgt cgctaaaagc ttgtcgagaa 19500 gtactagagg atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa 19560 cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt 19620 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 19680 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 19740 tgtctggatc tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg 19800 aagctgagtt ggctgctggg tgcctaatga gtgagctaac tcacattaat tgcccggaat 19860 attaatagat catggagata attaaaatga taaccatctc gcaaataaat aagtatttta 19920 ctgttttcgt aacagttttg taataaaaaa acctataaat attccggatt attcataccg 19980 tcccaccatc gggcgcggat cccggtccga agcgcgcgga attcgccacc atggacgctc 20040 gtgctgtggc taagcgtccc cgtgaccccg ctgacgagga caacgagctg gtcaccgctc 20100 tgaaggctaa gcgtgaagtg aacaccatct ccgtgcgtta cctgtaccac gctgaccacc 20160 aggctctgac cgctcgtttc ttcgtgcccg agggcctggt cgagttcgag gctcagcccg 20220 gtgctctgct gatccgtatg gaaaccggtt gcgactcccc ccgtcacctg tacatctccc 20280 tgtacctgct gggtatccgt gcttccaacg tgtccgcttc cacccgttgc ctgctcgagt 20340 ccgtgtacac cgcttccgct gctcgtgctg ctctgcagtg gctggacctg ggtccccacc 20400 tcctgcaccg tcgtctggaa accctgggtt gcgtcaagac cgtgtccctg ggtatcacct 20460 ccctgctgac ctgcgtgatg cgcggctacc tgtacaacac cctcaagacc gaggtgttcg 20520 ctctgatgat ccccaaggac atgtacctga cctgggagga aacccgcggt cgtctgcagt 20580 acgtgtacct gatcatcgtg tacgactacg acggtcccga gactcgtccc ggtatctacg 20640 tgctgacctc ctctatcgct cactggcaga ccctggtgga cgtggcccgt ggaaagttcg 20700 ctcgtgaacg ctgctccttc gtgaaccgtc gtatcacccg tccccgtcag atccccctgt 20760 gcaccggtgt catccaaaag ctgggctggt gcctggctga cgacatccac acctcattcc 20820 tcgtgcacaa ggaactgaag ctgtccgtcg tgcgtctgga caacttctcc gtcgagctgg 20880 gcgacttccg cgagttcgtg taaaagcttg tcgagaagta ctagaggatc ataatcagcc 20940 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 21000 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 21060 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 21120 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 21180 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc 21240 gctgagcaat aactatcata acccctagga gatccgaacc agataagtga aatctagttc 21300 caaactattt tgtcattttt aattttcgta ttagcttacg acgctacacc cagttcccat 21360 ctattttgtc actcttccct aaataatcct taaaaactcc atttccaccc ctcccagttc 21420 ccaactattt tgtccgccca ca 21442 <210> 8 <211> 6004 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 8 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccc ggtccgaagc 2700 gcgcggaatt caaaggccta cgtcgacgcc accatggaat cccgtatctg gtgcctggtc 2760 gtgtgcgtga acctgtgcat cgtgtgcctg ggtgctgctg tgtcctcctc ctccacccgt 2820 ggcacctccg ctacccactc ccaccactcc tcccacacca cctccgccgc tcactcccgt 2880 tccggttccg tgtcccagcg tgtgacctcc tcccagaccg tgtcccacgg tgtcaacgag 2940 actatctaca acaccaccct gaagtacggc gacgtcgtgg gtgtcaacac caccaagtac 3000 ccctaccgtg tgtgctccat ggctcagggc accgacctga tccgtttcga gcgtaacatc 3060 gtgtgcacct ccatgaagcc catcaacgag gacctggacg agggtatcat ggtggtgtac 3120 aagcgcaaca tcgtggctca caccttcaag gtccgcgtgt accagaaggt gctgaccttc 3180 cgtcgttcct acgcttacat ccacaccact tacctgctgg gttccaacac cgagtacgtg 3240 gcccctccca tgtgggagat ccaccacatc aactcccact cccagtgcta ctcctcttac 3300 tcccgtgtga tcgctggcac cgtgttcgtg gcttaccacc gtgactccta cgagaacaag 3360 accatgcagc tgatgcccga cgactactcc aacacccact ccacccgtta cgtgaccgtg 3420 aaggaccagt ggcactcccg tggttccacc tggctgtacc gtgaaacctg caacctgaac 3480 tgcatggtca ccatcaccac cgctcgttcc aagtaccctt accacttctt cgctacctcc 3540 accggcgacg tggtggacat ctcccccttc tacaacggta ctaaccgtaa cgcttcctac 3600 ttcggcgaga acgctgacaa gttcttcatc ttccccaact acaccatcgt gtccgacttc 3660 ggtcgtccca actccgctct ggaaacccac cgtctggtgg ctttcttgga gcgtgctgac 3720 tccgtgatct cctgggacat ccaggacgag aagaacgtga cctgccagct gaccttctgg 3780 gaggcttccg agcgtaccat ccgttccgag gctgaggact cctaccactt ctccagcgct 3840 aagatgaccg ctaccttcct gtccaagaaa caagaggtca acatgtccga ctccgccctg 3900 gactgcgtgc gtgacgaggc tatcaacaag ctgcagcaga tcttcaacac ctcctacaac 3960 cagacctacg agaagtacgg aaacgtgtcc gtgttcgaga ctaccggtgg cctggtggtg 4020 ttctggcagg gtatcaagca gaagtccctg gtcgagctgg aacgtctggc taaccgttcc 4080 tccctgaacc tgacccacaa ccgtaccaag cgttccaccg acggcaacaa cgctactcac 4140 ctgtccaaca tggaatccgt gcacaacctg gtgtacgctc agctgcagtt cacctacgac 4200 accctgcgcg gttacatcaa ccgtgctctg gctcagatcg ctgaggcttg gtgcgtggac 4260 cagcgtcgta ccctggaagt gttcaaggaa ctgtccaaga tcaacccctc cgctatcctg 4320 tccgccatct acaacaagcc tatcgctgct cgtttcatgg gcgacgtgct gggcctggct 4380 tcctgcgtga ccatcaacca gacttccgtg aaggtgctgc gtgacatgaa cgtgaaggaa 4440 tcccccggtc gttgctactc ccgtcccgtg gtcatcttca acttcgctaa ctcctcctac 4500 gtgcagtacg gccagctggg cgaggacaac gagatcctgc tgggcaacca ccgtaccgag 4560 gaatgccagc tgccctccct gaagatcttc atcgctggca actccgctta cgaatacgtg 4620 gactacctgt tcaagcgcat gatcgacctg tcctccatct ctaccgtgga ctccatgatc 4680 gctctggaca tcgaccccct ggaaaacacc gacttccgtg tgctggaact gtactcccag 4740 aaggaactgc gttccatcaa cgtgttcgac ctggaagaga tcatgcgcga gttcaactcc 4800 tacaagcagc gtgttaagta cgtcgaggac aaggtggtgg accccctgcc cccctacctg 4860 aagggactgg acgacctgat gtccggcctg ggagctgccg gcaaggctgt gggtgtcgct 4920 atcggtgctg tgggtggtgc tgtggcttcc gtggtcgagg gtgtcgccac cttcctgaag 4980 aaccccttcg gtgctttcac catcatcctg gtggctatcg ctgtggtcat catcatctac 5040 ctgatctaca cccgtcagcg tcgtctgtgc atgcagcccc tgcagaacct gttcccctac 5100 ctggtgtccg ctgacggtac taccgtgacc tccggcaaca ccaaggacac ctccctgcag 5160 gctcccccat cctacgagga atccgtctac aactccggtc gcaagggtcc cggtccccct 5220 tcctccgacg cttctaccgc tgctccccca tacaccaacg agcaggctta ccagatgctg 5280 ctggctctcg tgcgtctgga cgctgagcag cgtgcacagc agaacggcac cgactccctg 5340 gacggccaga ccggaaccca ggacaagggc cagaagccca acctgctgga ccgtctgcgt 5400 caccgcaaga acggttaccg tcacctgaag gactccgacg aggaagagaa cgtctaaggc 5460 gcgccaagct tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg 5520 ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg 5580 caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca 5640 tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac 5700 tcatcaatgt atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct 5760 gctaacaaag cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca 5820 taacccctag gagatccgaa ccagataagt gaaatctagt tccaaactat tttgtcattt 5880 ttaattttcg tattagctta cgacgctaca cccagttccc atctattttg tcactcttcc 5940 ctaaataatc cttaaaaact ccatttccac ccctcccagt tcccaactat tttgtccgcc 6000 caca 6004 <210> 9 <211> 11317 <212> DNA <213> Artificial <220> <223> Synthetic sequence <400> 9 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgctaaggc 4440 gccaagcttt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 4500 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 4560 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 4620 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 4680 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 4740 ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactatcat 4800 aacccctagg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat 4860 ccggatctga acaggaggga cagctgatag aaacagaagc cactggagca cctcaaaaac 4920 accatcatac actaaatcag taagttggca gcatcacccg acgcactttg cgccgaataa 4980 atacctgtga cggaagatca cttcgcagaa taaataaatc ctggtgtccc tgttgatacc 5040 gggaagccct gggccaactt ttggcgaaaa tgagacgttg atcggcacgt aagaggttcc 5100 aactttcacc ataatgaaat aagatcacta ccgggcgtat tttttgagtt atcgagattt 5160 tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac cgttgatata 5220 tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca atgtacctat 5280 aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa aaataagcac 5340 aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca tccggaattc 5400 cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc ttgttacacc 5460 gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca cgacgatttc 5520 cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa cctggcctat 5580 ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg ggtgagtttc 5640 accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt tttcaccatg 5700 ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca ggttcatcat 5760 gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca gtactgcgat 5820 gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta aacgcctggt 5880 tgctacgcct gaataagtga taataagcgg atgaatggca gaaattcgaa agcaaattcg 5940 acccggtcgt cggttcaggg cagggtcgtt aaatagccgc ttatgtctat tgctggttta 6000 ccggtttatt gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc tgaggccagt 6060 ttgctcaggc tctccccgtg gaggtaataa ttgacgatat gatcatttat tctgcctccc 6120 agctgacatt catccggggt cagcaccgtt tctgcggact ggctttctac gtgttccgct 6180 tcctttagca gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat tctgtcagcc 6240 gttaagtgtt cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg 6300 ttacatccct ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat 6360 attctttttt ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat 6420 taattttatt gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag 6480 ccatgagagc ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta 6540 cgttaaacat gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt 6600 tgaactgctg atcaacagat cctctacgcg gccgcggtac cataacttcg tatagcatac 6660 attatacgaa gttatctggt ttaaacgtac ccgtagtggc tatggcaggg cttgccgccc 6720 cgacgttggc tgcgagccct gggccttcac ccgaacttgg gggttggggt ggggaaaagg 6780 aagaaacgcg ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca gagtgccagc 6840 cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt tttattctgt 6900 ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg tgtttcagtt 6960 agcctccccc atctcccggt accgcatgct atgcatcagc tgctagctta gcgagcgtcc 7020 acagcctggg gaccgtaacg ggagtgagcg ggcaggttca cacgggtctg cttcagctca 7080 gggggcaggc cagcgtagta cttgtccagg tgacgcagca ggggggggtc cagctggtga 7140 cgcaggcaga attccttcac agcgttgtac aggccgtaga acagggtgat accctcggga 7200 gcagcagcgg tggacacggg cagacgcaca gcacggttgg tacgggtagc ctcgttacgg 7260 atagccacca ccacgttgaa cagggagggg ggcaccagct cgaaacccag cacgtgttcg 7320 gtgaagatgg aacgaccgta ggacagacga gtcaggtcgt aaccacggca caggtcgtcc 7380 acgcaagtgt acacagcggg ggaaccgtcg ccgcactcgg agtaaccgcg catcacggtc 7440 atccaacggg gagcggtgtc ggaggacagc agggtcagca gagcacgcag ctggtcgggg 7500 ttgttgtaca gcagggccag ggtgtccagg aaagcgtcgt ccagcagcac ggagttagca 7560 gcctcggggg tcacgggacg gtaacggatc agctgggaca ggggaccgtc cctacgggtc 7620 acgttgacca ggggacgcag ccaggactcg tacttgtcgc cctggaacac ctctcccagc 7680 aggcaacgac gggtcagctc ggggcactca gcgggcacct tctcagccac ggtgggagcc 7740 acggacacgg tagcggagga cacgatgggc agcagcaggc agcaccacag cagagccacg 7800 ggaccggggg agaaggagaa accgcagtcg ggacgacggc acatggtggc tcgagatccc 7860 gggtgatcaa gtcttcgtcg agtgattgta aataaaatgt aatttacagt atagtatttt 7920 aattaatata caaatgattt gataataatt cttatttaac tataatatat tgtgttgggt 7980 tgaattaaag gtccgtatac tagtatcgat tcgcgaccta ctccggaata ttaatagatc 8040 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 8100 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 8160 ggcgcggatc cgccaccatg tcccccaaga acctgacccc cttcctgacc gctctgtggc 8220 tgctgctggg ccactcccgt gtgcctcgtg tgcgtgctga ggaatgctgc gagttcatca 8280 acgtgaacca cccccccgag cgctgctacg acttcaagat gtgcaaccgt ttcaccgtgg 8340 ctctgcgttg ccccgacggc gaagtgtgct actcccccga aaagaccgct gagatccgtg 8400 gtatcgtgac caccatgacc cactccctga cccgtcaggt ggtgcacaac aagctgacct 8460 cttgcaacta caaccccctg tacctcgagg ctgacggtcg tatccgttgc ggcaaggtca 8520 acgacaaggc tcagtacctg ctgggtgctg ctggttccgt gccctaccgt tggatcaacc 8580 tcgagtacga caagatcacc cgtatcgtgg gcctggacca gtacctcgag tccgtgaaga 8640 agcacaagcg tctggacgtg tgccgtgcta agatgggtta catgctgcag taaaagcttg 8700 tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 8760 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 8820 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 8880 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 8940 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9000 cgaaaggaag ctgagttggc tgctgtggct agctttgttt aactttaaga aggagataca 9060 tctagaccgg aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata 9120 aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg 9180 attattcata ccgtcccacc atcgggcgcg gatccgccac catgctgcgt ctgctgctgc 9240 gtcaccactt ccactgcctg ctgctgtgcg ctgtgtgggc taccccctgc ctggcttccc 9300 cttggtccac cctgaccgct aaccagaacc cctccccacc ctggtccaag ctgacctact 9360 ccaagcccca cgacgctgct accttctact gccccttcct gtacccatcc ccccctcgtt 9420 ccccactgca gttctccggt ttccagcgtg tgctgaccgg tcccgagtgc cgtaacgaga 9480 ctctgtacct gctgtacaac cgcgagggcc agaccctggt cgagaggtcc tccacctggg 9540 tcaagaaggt catctggtac ttgtccggtc gtaaccagac catcctgcag cgtatgcccc 9600 gtaccgcttc caagccctcc gacggcaacg tgcagatctc cgtcgaggac gctaagatct 9660 tcggtgctca catggtgccc aagcagacca agctgctgcg tttcgtggtc aacgacggca 9720 cccgttacca gatgtgcgtg atgaagctcg agtcctgggc tcacgtgttc cgtgactact 9780 ccgtgtcctt ccaagtgcgc ctgaccttca ccgaggctaa caaccagacc tacaccttct 9840 gcacccaccc caacctgatc gtgtaaaagc ttgtcgagaa gtactagagg atcataatca 9900 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 9960 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 10020 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 10080 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 10140 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctggg 10200 tgcctaatga gtgagctaac tcacattaat tgcccggaat attaatagat catggagata 10260 attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt aacagttttg 10320 taataaaaaa acctataaat attccggatt attcataccg tcccaccatc gggcgcggat 10380 ccgccaccat gcgtctgtgc cgtgtgtggc tgtccgtgtg cctgtgcgct gtggtgctgg 10440 gccagtgcca gcgtgaaacc gctgagaaga acgactacta ccgtgtgccc cactactggg 10500 acgcttgctc ccgtgctctg cccgaccaga cccgttacaa gtacgtcgag cagctggtgg 10560 acctgaccct gaactaccac tacgacgctt cccacggcct ggacaacttc gacgtgctga 10620 agcgtatcaa cgtgaccgag gtgtccctgc tgatctccga cttccgtcgt cagaaccgtc 10680 gtggtggcac caacaagcgt accaccttca acgctgctgg ttccctggct ccccacgctc 10740 gttccctcga gttctccgtg cgtctgttcg ctaactaaaa gcttgtcgag aagtactaga 10800 ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac 10860 acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg 10920 cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt 10980 tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga 11040 tctgatcact gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag 11100 ttggctgctg ccaccgctga gcaataacta tcataacccc taggagatcc gaaccagata 11160 agtgaaatct agttccaaac tattttgtca tttttaattt tcgtattagc ttacgacgct 11220 acacccagtt cccatctatt ttgtcactct tccctaaata atccttaaaa actccatttc 11280 cacccctccc agttcccaac tattttgtcc gcccaca 11317 <210> 10 <211> 11317 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 10 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgctaaggc 4440 gccaagcttt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 4500 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 4560 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 4620 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 4680 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 4740 ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactatcat 4800 aacccctagg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat 4860 ccggatctga acaggaggga cagctgatag aaacagaagc cactggagca cctcaaaaac 4920 accatcatac actaaatcag taagttggca gcatcacccg acgcactttg cgccgaataa 4980 atacctgtga cggaagatca cttcgcagaa taaataaatc ctggtgtccc tgttgatacc 5040 gggaagccct gggccaactt ttggcgaaaa tgagacgttg atcggcacgt aagaggttcc 5100 aactttcacc ataatgaaat aagatcacta ccgggcgtat tttttgagtt atcgagattt 5160 tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac cgttgatata 5220 tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca atgtacctat 5280 aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa aaataagcac 5340 aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca tccggaattc 5400 cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc ttgttacacc 5460 gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca cgacgatttc 5520 cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa cctggcctat 5580 ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg ggtgagtttc 5640 accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt tttcaccatg 5700 ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca ggttcatcat 5760 gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca gtactgcgat 5820 gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta aacgcctggt 5880 tgctacgcct gaataagtga taataagcgg atgaatggca gaaattcgaa agcaaattcg 5940 acccggtcgt cggttcaggg cagggtcgtt aaatagccgc ttatgtctat tgctggttta 6000 ccggtttatt gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc tgaggccagt 6060 ttgctcaggc tctccccgtg gaggtaataa ttgacgatat gatcatttat tctgcctccc 6120 agctgacatt catccggggt cagcaccgtt tctgcggact ggctttctac gtgttccgct 6180 tcctttagca gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat tctgtcagcc 6240 gttaagtgtt cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg 6300 ttacatccct ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat 6360 attctttttt ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat 6420 taattttatt gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag 6480 ccatgagagc ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta 6540 cgttaaacat gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt 6600 tgaactgctg atcaacagat cctctacgcg gccgcggtac cataacttcg tatagcatac 6660 attatacgaa gttatctggt ttaaacgtac ccgtagtggc tatggcaggg cttgccgccc 6720 cgacgttggc tgcgagccct gggccttcac ccgaacttgg gggttggggt ggggaaaagg 6780 aagaaacgcg ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca gagtgccagc 6840 cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt tttattctgt 6900 ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg tgtttcagtt 6960 agcctccccc atctcccggt accgcatgct atgcatcagc tgctagctta gcgagcgtcc 7020 acagcctggg gaccgtaacg ggagtgagcg ggcaggttca cacgggtctg cttcagctca 7080 gggggcaggc cagcgtagta cttgtccagg tgacgcagca ggggggggtc cagctggtga 7140 cgcaggcaga attccttcac agcgttgtac aggccgtaga acagggtgat accctcggga 7200 gcagcagcgg tggacacggg cagacgcaca gcacggttgg tacgggtagc ctcgttacgg 7260 atagccacca ccacgttgaa cagggagggg ggcaccagct cgaaacccag cacgtgttcg 7320 gtgaagatgg aacgaccgta ggacagacga gtcaggtcgt aaccacggca caggtcgtcc 7380 acgcaagtgt acacagcggg ggaaccgtcg ccgcactcgg agtaaccgcg catcacggtc 7440 atccaacggg gagcggtgtc ggaggacagc agggtcagca gagcacgcag ctggtcgggg 7500 ttgttgtaca gcagggccag ggtgtccagg aaagcgtcgt ccagcagcac ggagttagca 7560 gcctcggggg tcacgggacg gtaacggatc agctgggaca ggggaccgtc cctacgggtc 7620 acgttgacca ggggacgcag ccaggactcg tacttgtcgc cctggaacac ctctcccagc 7680 aggcaacgac gggtcagctc ggggcactca gcgggcacct tctcagccac ggtgggagcc 7740 acggacacgg tagcggagga cacgatgggc agcagcaggc agcaccacag cagagccacg 7800 ggaccggggg agaaggagaa accgcagtcg ggacgacggc acatggtggc tcgagatccc 7860 gggtgatcaa gtcttcgtcg agtgattgta aataaaatgt aatttacagt atagtatttt 7920 aattaatata caaatgattt gataataatt cttatttaac tataatatat tgtgttgggt 7980 tgaattaaag gtccgtatac tagtatcgat tcgcgaccta ctccggaata ttaatagatc 8040 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 8100 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 8160 ggcgcggatc cgccaccatg aactccaagg acctgacccc cttcctgacc accctgtggc 8220 tgctgctgga ccactcccgt gtgcctcgtg tgcgtgctga ggaatgctgc gaagtgatca 8280 acgtgaacca cccccccgag cgctgctacg acttcaagat gtgcaacctg ttcaccgtgg 8340 ctctgcgttg ccccgacggc gaagtgtgct actcccccga aaagaccgct gagatccgtg 8400 gtatcgtgac caccatgacc cactccctga cccgtcaagt gatccacaac aagctgacca 8460 gctgcaacta caaccccctg tacctcgagg ctgacggtcg tatccgttgc ggcaaggtgt 8520 ccgacaaggc tcagtacctg ctgggtgctg ctggttccgt gccctaccgt tggatcaacc 8580 tcgagtacga caagatcacc cgtatcgtgg gcctggacca gtacctcgag tccgtgaaga 8640 agcacaagcg tctggacgtg tgccgtgcta agatgggtta catgctgcag taaaagcttg 8700 tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 8760 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 8820 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 8880 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 8940 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9000 cgaaaggaag ctgagttggc tgctgtggct agctttgttt aactttaaga aggagataca 9060 tctagaccgg aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata 9120 aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg 9180 attattcata ccgtcccacc atcgggcgcg gatccgccac catgctgcgt ctgctgctgc 9240 gtcaccactt ccactgcctg ctgctgtgcg ctgtgtgggc taccccctgc ctggcttccc 9300 cttggtccac cctgaccgct aaccagaacc cctccccacc ctggtccaag ctgacctact 9360 ccaagcccca cgacgctgct accttctact gccccttcct gtacccatcc ccccctcgtt 9420 ccccactgca gttctccggt ttccagcgtg tgctgaccgg tcccgagtgc cgtaacgaga 9480 ctctgtacct gctgtacaac cgcgagggcc agaccctggt cgagaggtcc tccacctggg 9540 tcaagaaggt catctggtac ttgtccggtc gtaaccagac catcctgcag cgtatgcccc 9600 gtaccgcttc caagccctcc gacggcaacg tgcagatctc cgtcgaggac gctaagatct 9660 tcggtgctca catggtgccc aagcagacca agctgctgcg tttcgtggtc aacgacggca 9720 cccgttacca gatgtgcgtg atgaagctcg agtcctgggc tcacgtgttc cgtgactact 9780 ccgtgtcctt ccaagtgcgc ctgaccttca ccgaggctaa caaccagacc tacaccttct 9840 gcacccaccc caacctgatc gtgtaaaagc ttgtcgagaa gtactagagg atcataatca 9900 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 9960 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 10020 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 10080 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 10140 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctggg 10200 tgcctaatga gtgagctaac tcacattaat tgcccggaat attaatagat catggagata 10260 attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt aacagttttg 10320 taataaaaaa acctataaat attccggatt attcataccg tcccaccatc gggcgcggat 10380 ccgccaccat gcgtctgtgc cgtgtgtggc tgtccgtgtg cctgtgcgct gtggtgctgg 10440 gccagtgcca gcgtgaaacc gctgagaaga acgactacta ccgtgtgccc cactactggg 10500 acgcttgctc ccgtgctctg cccgaccaga cccgttacaa gtacgtcgag cagctggtgg 10560 acctgaccct gaactaccac tacgacgctt cccacggcct ggacaacttc gacgtgctga 10620 agcgtatcaa cgtgaccgag gtgtccctgc tgatctccga cttccgtcgt cagaaccgtc 10680 gtggtggcac caacaagcgt accaccttca acgctgctgg ttccctggct ccccacgctc 10740 gttccctcga gttctccgtg cgtctgttcg ctaactaaaa gcttgtcgag aagtactaga 10800 ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac 10860 acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg 10920 cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt 10980 tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga 11040 tctgatcact gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag 11100 ttggctgctg ccaccgctga gcaataacta tcataacccc taggagatcc gaaccagata 11160 agtgaaatct agttccaaac tattttgtca tttttaattt tcgtattagc ttacgacgct 11220 acacccagtt cccatctatt ttgtcactct tccctaaata atccttaaaa actccatttc 11280 cacccctccc agttcccaac tattttgtcc gcccaca 11317 <210> 11 <211> 11363 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 11 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgctaaggc 4440 gccaagcttt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 4500 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 4560 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 4620 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 4680 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 4740 ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactatcat 4800 aacccctagg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat 4860 ccggatctga acaggaggga cagctgatag aaacagaagc cactggagca cctcaaaaac 4920 accatcatac actaaatcag taagttggca gcatcacccg acgcactttg cgccgaataa 4980 atacctgtga cggaagatca cttcgcagaa taaataaatc ctggtgtccc tgttgatacc 5040 gggaagccct gggccaactt ttggcgaaaa tgagacgttg atcggcacgt aagaggttcc 5100 aactttcacc ataatgaaat aagatcacta ccgggcgtat tttttgagtt atcgagattt 5160 tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac cgttgatata 5220 tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca atgtacctat 5280 aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa aaataagcac 5340 aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca tccggaattc 5400 cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc ttgttacacc 5460 gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca cgacgatttc 5520 cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa cctggcctat 5580 ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg ggtgagtttc 5640 accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt tttcaccatg 5700 ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca ggttcatcat 5760 gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca gtactgcgat 5820 gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta aacgcctggt 5880 tgctacgcct gaataagtga taataagcgg atgaatggca gaaattcgaa agcaaattcg 5940 acccggtcgt cggttcaggg cagggtcgtt aaatagccgc ttatgtctat tgctggttta 6000 ccggtttatt gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc tgaggccagt 6060 ttgctcaggc tctccccgtg gaggtaataa ttgacgatat gatcatttat tctgcctccc 6120 agctgacatt catccggggt cagcaccgtt tctgcggact ggctttctac gtgttccgct 6180 tcctttagca gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat tctgtcagcc 6240 gttaagtgtt cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg 6300 ttacatccct ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat 6360 attctttttt ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat 6420 taattttatt gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag 6480 ccatgagagc ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta 6540 cgttaaacat gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt 6600 tgaactgctg atcaacagat cctctacgcg gccgcggtac cataacttcg tatagcatac 6660 attatacgaa gttatctggt ttaaacgtac ccgtagtggc tatggcaggg cttgccgccc 6720 cgacgttggc tgcgagccct gggccttcac ccgaacttgg gggttggggt ggggaaaagg 6780 aagaaacgcg ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca gagtgccagc 6840 cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt tttattctgt 6900 ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg tgtttcagtt 6960 agcctccccc atctccggta ccgcatgcta tgcttagtga tggtggtggt gatggtggtg 7020 gctgcctccc cccccagacc cccctccgcc gcttccgcga gcgtccacag cctggggacc 7080 gtaacgggag tgagcgggca ggttcacacg ggtctgcttc agctcagggg gcaggccagc 7140 gtagtacttg tccaggtgac gcagcagggg ggggtccagc tggtgacgca ggcagaattc 7200 cttcacagcg ttgtacaggc cgtagaacag ggtgataccc tcgggagcag cagcggtgga 7260 cacgggcaga cgcacagcac ggttggtacg ggtagcctcg ttacggatag ccaccaccac 7320 gttgaacagg gaggggggca ccagctcgaa acccagcacg tgttcggtga agatggaacg 7380 accgtaggac agacgagtca ggtcgtaacc acggcacagg tcgtccacgc aagtgtacac 7440 agcgggggaa ccgtcgccgc actcggagta accgcgcatc acggtcatcc aacggggagc 7500 ggtgtcggag gacagcaggg tcagcagagc acgcagctgg tcggggttgt tgtacagcag 7560 ggccagggtg tccaggaaag cgtcgtccag cagcacggag ttagcagcct cgggggtcac 7620 gggacggtaa cggatcagct gggacagggg accgtcccta cgggtcacgt tgaccagggg 7680 acgcagccag gactcgtact tgtcgccctg gaacacctct cccagcaggc aacgacgggt 7740 cagctcgggg cactcagcgg gcaccttctc agccacggtg ggagccacgg acacggtagc 7800 ggaggacacg atgggcagca gcaggcagca ccacagcaga gccacgggac cgggggagaa 7860 ggagaaaccg cagtcgggac gacggcacat ggtggctcga gatcccgggt gatcaagtct 7920 tcgtcgagtg attgtaaata aaatgtaatt tacagtatag tattttaatt aatatacaaa 7980 tgatttgata ataattctta tttaactata atatattgtg ttgggttgaa ttaaaggtcc 8040 gtatactagt atcgattcgc gacctactcc ggaatattaa tagatcatgg agataattaa 8100 aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag ttttgtaata 8160 aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg cggatccgcc 8220 accatgtccc ccaagaacct gacccccttc ctgaccgctc tgtggctgct gctgggccac 8280 tcccgtgtgc ctcgtgtgcg tgctgaggaa tgctgcgagt tcatcaacgt gaaccacccc 8340 cccgagcgct gctacgactt caagatgtgc aaccgtttca ccgtggctct gcgttgcccc 8400 gacggcgaag tgtgctactc ccccgaaaag accgctgaga tccgtggtat cgtgaccacc 8460 atgacccact ccctgacccg tcaggtggtg cacaacaagc tgacctcttg caactacaac 8520 cccctgtacc tcgaggctga cggtcgtatc cgttgcggca aggtcaacga caaggctcag 8580 tacctgctgg gtgctgctgg ttccgtgccc taccgttgga tcaacctcga gtacgacaag 8640 atcacccgta tcgtgggcct ggaccagtac ctcgagtccg tgaagaagca caagcgtctg 8700 gacgtgtgcc gtgctaagat gggttacatg ctgcagtaaa agcttgtcga gaagtactag 8760 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 8820 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 8880 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 8940 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 9000 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 9060 gttggctgct gtggctagct ttgtttaact ttaagaagga gatacatcta gaccggaata 9120 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 9180 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 9240 cccaccatcg ggcgcggatc cgccaccatg ctgcgtctgc tgctgcgtca ccacttccac 9300 tgcctgctgc tgtgcgctgt gtgggctacc ccctgcctgg cttccccttg gtccaccctg 9360 accgctaacc agaacccctc cccaccctgg tccaagctga cctactccaa gccccacgac 9420 gctgctacct tctactgccc cttcctgtac ccatcccccc ctcgttcccc actgcagttc 9480 tccggtttcc agcgtgtgct gaccggtccc gagtgccgta acgagactct gtacctgctg 9540 tacaaccgcg agggccagac cctggtcgag aggtcctcca cctgggtcaa gaaggtcatc 9600 tggtacttgt ccggtcgtaa ccagaccatc ctgcagcgta tgccccgtac cgcttccaag 9660 ccctccgacg gcaacgtgca gatctccgtc gaggacgcta agatcttcgg tgctcacatg 9720 gtgcccaagc agaccaagct gctgcgtttc gtggtcaacg acggcacccg ttaccagatg 9780 tgcgtgatga agctcgagtc ctgggctcac gtgttccgtg actactccgt gtccttccaa 9840 gtgcgcctga ccttcaccga ggctaacaac cagacctaca ccttctgcac ccaccccaac 9900 ctgatcgtgt aaaagcttgt cgagaagtac tagaggatca taatcagcca taccacattt 9960 gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa 10020 atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc 10080 aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 10140 tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga 10200 tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgggtgcc taatgagtga 10260 gctaactcac attaattgcc cggaatatta atagatcatg gagataatta aaatgataac 10320 catctcgcaa ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct 10380 ataaatattc cggattattc ataccgtccc accatcgggc gcggatccgc caccatgcgt 10440 ctgtgccgtg tgtggctgtc cgtgtgcctg tgcgctgtgg tgctgggcca gtgccagcgt 10500 gaaaccgctg agaagaacga ctactaccgt gtgccccact actgggacgc ttgctcccgt 10560 gctctgcccg accagacccg ttacaagtac gtcgagcagc tggtggacct gaccctgaac 10620 taccactacg acgcttccca cggcctggac aacttcgacg tgctgaagcg tatcaacgtg 10680 accgaggtgt ccctgctgat ctccgacttc cgtcgtcaga accgtcgtgg tggcaccaac 10740 aagcgtacca ccttcaacgc tgctggttcc ctggctcccc acgctcgttc cctcgagttc 10800 tccgtgcgtc tgttcgctaa ctaaaagctt gtcgagaagt actagaggat cataatcagc 10860 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 10920 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 10980 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 11040 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 11100 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac 11160 cgctgagcaa taactatcat aacccctagg agatccgaac cagataagtg aaatctagtt 11220 ccaaactatt ttgtcatttt taattttcgt attagcttac gacgctacac ccagttccca 11280 tctattttgt cactcttccc taaataatcc ttaaaaactc catttccacc cctcccagtt 11340 cccaactatt ttgtccgccc aca 11363 <210> 12 <211> 11363 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 12 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgctaaggc 4440 gccaagcttt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 4500 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 4560 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 4620 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 4680 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 4740 ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactatcat 4800 aacccctagg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat 4860 ccggatctga acaggaggga cagctgatag aaacagaagc cactggagca cctcaaaaac 4920 accatcatac actaaatcag taagttggca gcatcacccg acgcactttg cgccgaataa 4980 atacctgtga cggaagatca cttcgcagaa taaataaatc ctggtgtccc tgttgatacc 5040 gggaagccct gggccaactt ttggcgaaaa tgagacgttg atcggcacgt aagaggttcc 5100 aactttcacc ataatgaaat aagatcacta ccgggcgtat tttttgagtt atcgagattt 5160 tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac cgttgatata 5220 tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca atgtacctat 5280 aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa aaataagcac 5340 aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca tccggaattc 5400 cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc ttgttacacc 5460 gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca cgacgatttc 5520 cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa cctggcctat 5580 ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg ggtgagtttc 5640 accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt tttcaccatg 5700 ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca ggttcatcat 5760 gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca gtactgcgat 5820 gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta aacgcctggt 5880 tgctacgcct gaataagtga taataagcgg atgaatggca gaaattcgaa agcaaattcg 5940 acccggtcgt cggttcaggg cagggtcgtt aaatagccgc ttatgtctat tgctggttta 6000 ccggtttatt gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc tgaggccagt 6060 ttgctcaggc tctccccgtg gaggtaataa ttgacgatat gatcatttat tctgcctccc 6120 agctgacatt catccggggt cagcaccgtt tctgcggact ggctttctac gtgttccgct 6180 tcctttagca gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat tctgtcagcc 6240 gttaagtgtt cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg 6300 ttacatccct ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat 6360 attctttttt ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat 6420 taattttatt gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag 6480 ccatgagagc ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta 6540 cgttaaacat gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt 6600 tgaactgctg atcaacagat cctctacgcg gccgcggtac cataacttcg tatagcatac 6660 attatacgaa gttatctggt ttaaacgtac ccgtagtggc tatggcaggg cttgccgccc 6720 cgacgttggc tgcgagccct gggccttcac ccgaacttgg gggttggggt ggggaaaagg 6780 aagaaacgcg ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca gagtgccagc 6840 cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt tttattctgt 6900 ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg tgtttcagtt 6960 agcctccccc atctccggta ccgcatgcta tgcttagtga tggtggtggt gatggtggtg 7020 gctgcctccc cccccagacc cccctccgcc gcttccgcga gcgtccacag cctggggacc 7080 gtaacgggag tgagcgggca ggttcacacg ggtctgcttc agctcagggg gcaggccagc 7140 gtagtacttg tccaggtgac gcagcagggg ggggtccagc tggtgacgca ggcagaattc 7200 cttcacagcg ttgtacaggc cgtagaacag ggtgataccc tcgggagcag cagcggtgga 7260 cacgggcaga cgcacagcac ggttggtacg ggtagcctcg ttacggatag ccaccaccac 7320 gttgaacagg gaggggggca ccagctcgaa acccagcacg tgttcggtga agatggaacg 7380 accgtaggac agacgagtca ggtcgtaacc acggcacagg tcgtccacgc aagtgtacac 7440 agcgggggaa ccgtcgccgc actcggagta accgcgcatc acggtcatcc aacggggagc 7500 ggtgtcggag gacagcaggg tcagcagagc acgcagctgg tcggggttgt tgtacagcag 7560 ggccagggtg tccaggaaag cgtcgtccag cagcacggag ttagcagcct cgggggtcac 7620 gggacggtaa cggatcagct gggacagggg accgtcccta cgggtcacgt tgaccagggg 7680 acgcagccag gactcgtact tgtcgccctg gaacacctct cccagcaggc aacgacgggt 7740 cagctcgggg cactcagcgg gcaccttctc agccacggtg ggagccacgg acacggtagc 7800 ggaggacacg atgggcagca gcaggcagca ccacagcaga gccacgggac cgggggagaa 7860 ggagaaaccg cagtcgggac gacggcacat ggtggctcga gatcccgggt gatcaagtct 7920 tcgtcgagtg attgtaaata aaatgtaatt tacagtatag tattttaatt aatatacaaa 7980 tgatttgata ataattctta tttaactata atatattgtg ttgggttgaa ttaaaggtcc 8040 gtatactagt atcgattcgc gacctactcc ggaatattaa tagatcatgg agataattaa 8100 aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag ttttgtaata 8160 aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg cggatccgcc 8220 accatgaact ccaaggacct gacccccttc ctgaccaccc tgtggctgct gctggaccac 8280 tcccgtgtgc ctcgtgtgcg tgctgaggaa tgctgcgaag tgatcaacgt gaaccacccc 8340 cccgagcgct gctacgactt caagatgtgc aacctgttca ccgtggctct gcgttgcccc 8400 gacggcgaag tgtgctactc ccccgaaaag accgctgaga tccgtggtat cgtgaccacc 8460 atgacccact ccctgacccg tcaagtgatc cacaacaagc tgaccagctg caactacaac 8520 cccctgtacc tcgaggctga cggtcgtatc cgttgcggca aggtgtccga caaggctcag 8580 tacctgctgg gtgctgctgg ttccgtgccc taccgttgga tcaacctcga gtacgacaag 8640 atcacccgta tcgtgggcct ggaccagtac ctcgagtccg tgaagaagca caagcgtctg 8700 gacgtgtgcc gtgctaagat gggttacatg ctgcagtaaa agcttgtcga gaagtactag 8760 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 8820 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 8880 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 8940 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 9000 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 9060 gttggctgct gtggctagct ttgtttaact ttaagaagga gatacatcta gaccggaata 9120 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 9180 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 9240 cccaccatcg ggcgcggatc cgccaccatg ctgcgtctgc tgctgcgtca ccacttccac 9300 tgcctgctgc tgtgcgctgt gtgggctacc ccctgcctgg cttccccttg gtccaccctg 9360 accgctaacc agaacccctc cccaccctgg tccaagctga cctactccaa gccccacgac 9420 gctgctacct tctactgccc cttcctgtac ccatcccccc ctcgttcccc actgcagttc 9480 tccggtttcc agcgtgtgct gaccggtccc gagtgccgta acgagactct gtacctgctg 9540 tacaaccgcg agggccagac cctggtcgag aggtcctcca cctgggtcaa gaaggtcatc 9600 tggtacttgt ccggtcgtaa ccagaccatc ctgcagcgta tgccccgtac cgcttccaag 9660 ccctccgacg gcaacgtgca gatctccgtc gaggacgcta agatcttcgg tgctcacatg 9720 gtgcccaagc agaccaagct gctgcgtttc gtggtcaacg acggcacccg ttaccagatg 9780 tgcgtgatga agctcgagtc ctgggctcac gtgttccgtg actactccgt gtccttccaa 9840 gtgcgcctga ccttcaccga ggctaacaac cagacctaca ccttctgcac ccaccccaac 9900 ctgatcgtgt aaaagcttgt cgagaagtac tagaggatca taatcagcca taccacattt 9960 gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa 10020 atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc 10080 aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 10140 tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga 10200 tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgggtgcc taatgagtga 10260 gctaactcac attaattgcc cggaatatta atagatcatg gagataatta aaatgataac 10320 catctcgcaa ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct 10380 ataaatattc cggattattc ataccgtccc accatcgggc gcggatccgc caccatgcgt 10440 ctgtgccgtg tgtggctgtc cgtgtgcctg tgcgctgtgg tgctgggcca gtgccagcgt 10500 gaaaccgctg agaagaacga ctactaccgt gtgccccact actgggacgc ttgctcccgt 10560 gctctgcccg accagacccg ttacaagtac gtcgagcagc tggtggacct gaccctgaac 10620 taccactacg acgcttccca cggcctggac aacttcgacg tgctgaagcg tatcaacgtg 10680 accgaggtgt ccctgctgat ctccgacttc cgtcgtcaga accgtcgtgg tggcaccaac 10740 aagcgtacca ccttcaacgc tgctggttcc ctggctcccc acgctcgttc cctcgagttc 10800 tccgtgcgtc tgttcgctaa ctaaaagctt gtcgagaagt actagaggat cataatcagc 10860 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 10920 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 10980 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 11040 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 11100 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac 11160 cgctgagcaa taactatcat aacccctagg agatccgaac cagataagtg aaatctagtt 11220 ccaaactatt ttgtcatttt taattttcgt attagcttac gacgctacac ccagttccca 11280 tctattttgt cactcttccc taaataatcc ttaaaaactc catttccacc cctcccagtt 11340 cccaactatt ttgtccgccc aca 11363 <210> 13 <211> 11432 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 13 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgctaaggc 4440 gccaagcttt gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt 4500 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 4560 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 4620 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 4680 atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc 4740 taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactatcata 4800 acccctaggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc 4860 cggatctgaa caggagggac agctgataga aacagaagcc actggagcac ctcaaaaaca 4920 ccatcataca ctaaatcagt aagttggcag catcacccga cgcactttgc gccgaataaa 4980 tacctgtgac ggaagatcac ttcgcagaat aaataaatcc tggtgtccct gttgataccg 5040 ggaagccctg ggccaacttt tggcgaaaat gagacgttga tcggcacgta agaggttcca 5100 actttcacca taatgaaata agatcactac cgggcgtatt ttttgagtta tcgagatttt 5160 caggagctaa ggaagctaaa atggagaaaa aaatcactgg atataccacc gttgatatat 5220 cccaatggca tcgtaaagaa cattttgagg catttcagtc agttgctcaa tgtacctata 5280 accagaccgt tcagctggat attacggcct ttttaaagac cgtaaagaaa aataagcaca 5340 agttttatcc ggcctttatt cacattcttg cccgcctgat gaatgctcat ccggaattcc 5400 gtatggcaat gaaagacggt gagctggtga tatgggatag tgttcaccct tgttacaccg 5460 ttttccatga gcaaactgaa acgttttcat cgctctggag tgaataccac gacgatttcc 5520 ggcagtttct acacatatat tcgcaagatg tggcgtgtta cggtgaaaac ctggcctatt 5580 tccctaaagg gtttattgag aatatgtttt tcgtctcagc caatccctgg gtgagtttca 5640 ccagttttga tttaaacgtg gccaatatgg acaacttctt cgcccccgtt ttcaccatgg 5700 gcaaatatta tacgcaaggc gacaaggtgc tgatgccgct ggcgattcag gttcatcatg 5760 ccgtttgtga tggcttccat gtcggcagaa tgcttaatga attacaacag tactgcgatg 5820 agtggcaggg cggggcgtaa tttttttaag gcagttattg gtgcccttaa acgcctggtt 5880 gctacgcctg aataagtgat aataagcgga tgaatggcag aaattcgaaa gcaaattcga 5940 cccggtcgtc ggttcagggc agggtcgtta aatagccgct tatgtctatt gctggtttac 6000 cggtttattg actaccggaa gcagtgtgac cgtgtgcttc tcaaatgcct gaggccagtt 6060 tgctcaggct ctccccgtgg aggtaataat tgacgatatg atcatttatt ctgcctccca 6120 gctgacattc atccggggtc agcaccgttt ctgcggactg gctttctacg tgttccgctt 6180 cctttagcag cccttgcgcc ctgagtgctt gcggcagcgt gaagctaatt ctgtcagccg 6240 ttaagtgttc ctgtgtcact caaaattgct ttgagaggct ctaagggctt ctcagtgcgt 6300 tacatccctg gcttgttgtc cacaaccgtt aaaccttaaa agctttaaaa gccttatata 6360 ttcttttttt tcttataaaa cttaaaacct tagaggctat ttaagttgct gatttatatt 6420 aattttattg ttcaaacatg agagcttagt acgtgaaaca tgagagctta gtacgttagc 6480 catgagagct tagtacgtta gccatgaggg tttagttcgt taaacatgag agcttagtac 6540 gttaaacatg agagcttagt acgtgaaaca tgagagctta gtacgtacta tcaacaggtt 6600 gaactgctga tcaacagatc ctctacgcgg ccgcggtacc ataacttcgt atagcataca 6660 ttatacgaag ttatctggtt taaacgtacc cgtagtggct atggcagggc ttgccgcccc 6720 gacgttggct gcgagccctg ggccttcacc cgaacttggg ggttggggtg gggaaaagga 6780 agaaacgcgg gcgtattggt cccaatgggg tctcggtggg gtatcgacag agtgccagcc 6840 ctgggaccga accccgcgtt tatgaacaaa cgacccaaca cccgtgcgtt ttattctgtc 6900 tttttattgc cgtcatagcg cgggttcctt ccggtattgt ctccttccgt gtttcagtta 6960 gcctccccca tctcccggta ccgcatgcta tgcttagtga tggtggtggt gatggtggtg 7020 gctgcctccc cccccagacc cccctccgcc gcttcctttt tcgaactgcg ggtggctcca 7080 gctacctccg ccgggcccct ggaacagaac ttccagggcg ccttagcgag cgtccacagc 7140 ctggggaccg taacgggagt gagcgggcag gttcacacgg gtctgcttca gctcaggggg 7200 caggccagcg tagtacttgt ccaggtgacg cagcaggggg gggtccagct ggtgacgcag 7260 gcagaattcc ttcacagcgt tgtacaggcc gtagaacagg gtgataccct cgggagcagc 7320 agcggtggac acgggcagac gcacagcacg gttggtacgg gtagcctcgt tacggatagc 7380 caccaccacg ttgaacaggg aggggggcac cagctcgaaa cccagcacgt gttcggtgaa 7440 gatggaacga ccgtaggaca gacgagtcag gtcgtaacca cggcacaggt cgtccacgca 7500 agtgtacaca gcgggggaac cgtcgccgca ctcggagtaa ccgcgcatca cggtcatcca 7560 acggggagcg gtgtcggagg acagcagggt cagcagagca cgcagctggt cggggttgtt 7620 gtacagcagg gccagggtgt ccaggaaagc gtcgtccagc agcacggagt tagcagcctc 7680 gggggtcacg ggacggtaac ggatcagctg ggacagggga ccgtccctac gggtcacgtt 7740 gaccagggga cgcagccagg actcgtactt gtcgccctgg aacacctctc ccagcaggca 7800 acgacgggtc agctcggggc actcagcggg caccttctca gccacggtgg gagccacgga 7860 cacggtagcg gaggacacga tgggcagcag caggcagcac cacagcagag ccacgggacc 7920 gggggagaag gagaaaccgc agtcgggacg acggcacatg gtggctcgag atcccgggtg 7980 atcaagtctt cgtcgagtga ttgtaaataa aatgtaattt acagtatagt attttaatta 8040 atatacaaat gatttgataa taattcttat ttaactataa tatattgtgt tgggttgaat 8100 taaaggtccg tatactagta tcgattcgcg acctactccg gaatattaat agatcatgga 8160 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 8220 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 8280 ggatccgcca ccatgtcccc caagaacctg acccccttcc tgaccgctct gtggctgctg 8340 ctgggccact cccgtgtgcc tcgtgtgcgt gctgaggaat gctgcgagtt catcaacgtg 8400 aaccaccccc ccgagcgctg ctacgacttc aagatgtgca accgtttcac cgtggctctg 8460 cgttgccccg acggcgaagt gtgctactcc cccgaaaaga ccgctgagat ccgtggtatc 8520 gtgaccacca tgacccactc cctgacccgt caggtggtgc acaacaagct gacctcttgc 8580 aactacaacc ccctgtacct cgaggctgac ggtcgtatcc gttgcggcaa ggtcaacgac 8640 aaggctcagt acctgctggg tgctgctggt tccgtgccct accgttggat caacctcgag 8700 tacgacaaga tcacccgtat cgtgggcctg gaccagtacc tcgagtccgt gaagaagcac 8760 aagcgtctgg acgtgtgccg tgctaagatg ggttacatgc tgcagtaaaa gcttgtcgag 8820 aagtactaga ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa 8880 aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac 8940 ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 9000 aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat 9060 catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca aagcccgaaa 9120 ggaagctgag ttggctgctg tggctagctt tgtttaactt taagaaggag atacatctag 9180 accggaatat taatagatca tggagataat taaaatgata accatctcgc aaataaataa 9240 gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat tccggattat 9300 tcataccgtc ccaccatcgg gcgcggatcc gccaccatgc tgcgtctgct gctgcgtcac 9360 cacttccact gcctgctgct gtgcgctgtg tgggctaccc cctgcctggc ttccccttgg 9420 tccaccctga ccgctaacca gaacccctcc ccaccctggt ccaagctgac ctactccaag 9480 ccccacgacg ctgctacctt ctactgcccc ttcctgtacc catccccccc tcgttcccca 9540 ctgcagttct ccggtttcca gcgtgtgctg accggtcccg agtgccgtaa cgagactctg 9600 tacctgctgt acaaccgcga gggccagacc ctggtcgaga ggtcctccac ctgggtcaag 9660 aaggtcatct ggtacttgtc cggtcgtaac cagaccatcc tgcagcgtat gccccgtacc 9720 gcttccaagc cctccgacgg caacgtgcag atctccgtcg aggacgctaa gatcttcggt 9780 gctcacatgg tgcccaagca gaccaagctg ctgcgtttcg tggtcaacga cggcacccgt 9840 taccagatgt gcgtgatgaa gctcgagtcc tgggctcacg tgttccgtga ctactccgtg 9900 tccttccaag tgcgcctgac cttcaccgag gctaacaacc agacctacac cttctgcacc 9960 caccccaacc tgatcgtgta aaagcttgtc gagaagtact agaggatcat aatcagccat 10020 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 10080 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 10140 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 10200 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 10260 cctagaagat ccggctgcta acaaagcccg aaaggaagct gagttggctg ctgggtgcct 10320 aatgagtgag ctaactcaca ttaattgccc ggaatattaa tagatcatgg agataattaa 10380 aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag ttttgtaata 10440 aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg cggatccgcc 10500 accatgcgtc tgtgccgtgt gtggctgtcc gtgtgcctgt gcgctgtggt gctgggccag 10560 tgccagcgtg aaaccgctga gaagaacgac tactaccgtg tgccccacta ctgggacgct 10620 tgctcccgtg ctctgcccga ccagacccgt tacaagtacg tcgagcagct ggtggacctg 10680 accctgaact accactacga cgcttcccac ggcctggaca acttcgacgt gctgaagcgt 10740 atcaacgtga ccgaggtgtc cctgctgatc tccgacttcc gtcgtcagaa ccgtcgtggt 10800 ggcaccaaca agcgtaccac cttcaacgct gctggttccc tggctcccca cgctcgttcc 10860 ctcgagttct ccgtgcgtct gttcgctaac taaaagcttg tcgagaagta ctagaggatc 10920 ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc 10980 cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct 11040 tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 11100 ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga 11160 tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc 11220 tgctgccacc gctgagcaat aactatcata acccctagga gatccgaacc agataagtga 11280 aatctagttc caaactattt tgtcattttt aattttcgta ttagcttacg acgctacacc 11340 cagttcccat ctattttgtc actcttccct aaataatcct taaaaactcc atttccaccc 11400 ctcccagttc ccaactattt tgtccgccca ca 11432 <210> 14 <211> 11432 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 14 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgctaaggc 4440 gccaagcttt gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt 4500 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 4560 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 4620 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 4680 atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc 4740 taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactatcata 4800 acccctaggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc 4860 cggatctgaa caggagggac agctgataga aacagaagcc actggagcac ctcaaaaaca 4920 ccatcataca ctaaatcagt aagttggcag catcacccga cgcactttgc gccgaataaa 4980 tacctgtgac ggaagatcac ttcgcagaat aaataaatcc tggtgtccct gttgataccg 5040 ggaagccctg ggccaacttt tggcgaaaat gagacgttga tcggcacgta agaggttcca 5100 actttcacca taatgaaata agatcactac cgggcgtatt ttttgagtta tcgagatttt 5160 caggagctaa ggaagctaaa atggagaaaa aaatcactgg atataccacc gttgatatat 5220 cccaatggca tcgtaaagaa cattttgagg catttcagtc agttgctcaa tgtacctata 5280 accagaccgt tcagctggat attacggcct ttttaaagac cgtaaagaaa aataagcaca 5340 agttttatcc ggcctttatt cacattcttg cccgcctgat gaatgctcat ccggaattcc 5400 gtatggcaat gaaagacggt gagctggtga tatgggatag tgttcaccct tgttacaccg 5460 ttttccatga gcaaactgaa acgttttcat cgctctggag tgaataccac gacgatttcc 5520 ggcagtttct acacatatat tcgcaagatg tggcgtgtta cggtgaaaac ctggcctatt 5580 tccctaaagg gtttattgag aatatgtttt tcgtctcagc caatccctgg gtgagtttca 5640 ccagttttga tttaaacgtg gccaatatgg acaacttctt cgcccccgtt ttcaccatgg 5700 gcaaatatta tacgcaaggc gacaaggtgc tgatgccgct ggcgattcag gttcatcatg 5760 ccgtttgtga tggcttccat gtcggcagaa tgcttaatga attacaacag tactgcgatg 5820 agtggcaggg cggggcgtaa tttttttaag gcagttattg gtgcccttaa acgcctggtt 5880 gctacgcctg aataagtgat aataagcgga tgaatggcag aaattcgaaa gcaaattcga 5940 cccggtcgtc ggttcagggc agggtcgtta aatagccgct tatgtctatt gctggtttac 6000 cggtttattg actaccggaa gcagtgtgac cgtgtgcttc tcaaatgcct gaggccagtt 6060 tgctcaggct ctccccgtgg aggtaataat tgacgatatg atcatttatt ctgcctccca 6120 gctgacattc atccggggtc agcaccgttt ctgcggactg gctttctacg tgttccgctt 6180 cctttagcag cccttgcgcc ctgagtgctt gcggcagcgt gaagctaatt ctgtcagccg 6240 ttaagtgttc ctgtgtcact caaaattgct ttgagaggct ctaagggctt ctcagtgcgt 6300 tacatccctg gcttgttgtc cacaaccgtt aaaccttaaa agctttaaaa gccttatata 6360 ttcttttttt tcttataaaa cttaaaacct tagaggctat ttaagttgct gatttatatt 6420 aattttattg ttcaaacatg agagcttagt acgtgaaaca tgagagctta gtacgttagc 6480 catgagagct tagtacgtta gccatgaggg tttagttcgt taaacatgag agcttagtac 6540 gttaaacatg agagcttagt acgtgaaaca tgagagctta gtacgtacta tcaacaggtt 6600 gaactgctga tcaacagatc ctctacgcgg ccgcggtacc ataacttcgt atagcataca 6660 ttatacgaag ttatctggtt taaacgtacc cgtagtggct atggcagggc ttgccgcccc 6720 gacgttggct gcgagccctg ggccttcacc cgaacttggg ggttggggtg gggaaaagga 6780 agaaacgcgg gcgtattggt cccaatgggg tctcggtggg gtatcgacag agtgccagcc 6840 ctgggaccga accccgcgtt tatgaacaaa cgacccaaca cccgtgcgtt ttattctgtc 6900 tttttattgc cgtcatagcg cgggttcctt ccggtattgt ctccttccgt gtttcagtta 6960 gcctccccca tctcccggta ccgcatgcta tgcttagtga tggtggtggt gatggtggtg 7020 gctgcctccc cccccagacc cccctccgcc gcttcctttt tcgaactgcg ggtggctcca 7080 gctacctccg ccgggcccct ggaacagaac ttccagggcg ccttagcgag cgtccacagc 7140 ctggggaccg taacgggagt gagcgggcag gttcacacgg gtctgcttca gctcaggggg 7200 caggccagcg tagtacttgt ccaggtgacg cagcaggggg gggtccagct ggtgacgcag 7260 gcagaattcc ttcacagcgt tgtacaggcc gtagaacagg gtgataccct cgggagcagc 7320 agcggtggac acgggcagac gcacagcacg gttggtacgg gtagcctcgt tacggatagc 7380 caccaccacg ttgaacaggg aggggggcac cagctcgaaa cccagcacgt gttcggtgaa 7440 gatggaacga ccgtaggaca gacgagtcag gtcgtaacca cggcacaggt cgtccacgca 7500 agtgtacaca gcgggggaac cgtcgccgca ctcggagtaa ccgcgcatca cggtcatcca 7560 acggggagcg gtgtcggagg acagcagggt cagcagagca cgcagctggt cggggttgtt 7620 gtacagcagg gccagggtgt ccaggaaagc gtcgtccagc agcacggagt tagcagcctc 7680 gggggtcacg ggacggtaac ggatcagctg ggacagggga ccgtccctac gggtcacgtt 7740 gaccagggga cgcagccagg actcgtactt gtcgccctgg aacacctctc ccagcaggca 7800 acgacgggtc agctcggggc actcagcggg caccttctca gccacggtgg gagccacgga 7860 cacggtagcg gaggacacga tgggcagcag caggcagcac cacagcagag ccacgggacc 7920 gggggagaag gagaaaccgc agtcgggacg acggcacatg gtggctcgag atcccgggtg 7980 atcaagtctt cgtcgagtga ttgtaaataa aatgtaattt acagtatagt attttaatta 8040 atatacaaat gatttgataa taattcttat ttaactataa tatattgtgt tgggttgaat 8100 taaaggtccg tatactagta tcgattcgcg acctactccg gaatattaat agatcatgga 8160 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 8220 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 8280 ggatccgcca ccatgaactc caaggacctg acccccttcc tgaccaccct gtggctgctg 8340 ctggaccact cccgtgtgcc tcgtgtgcgt gctgaggaat gctgcgaagt gatcaacgtg 8400 aaccaccccc ccgagcgctg ctacgacttc aagatgtgca acctgttcac cgtggctctg 8460 cgttgccccg acggcgaagt gtgctactcc cccgaaaaga ccgctgagat ccgtggtatc 8520 gtgaccacca tgacccactc cctgacccgt caagtgatcc acaacaagct gaccagctgc 8580 aactacaacc ccctgtacct cgaggctgac ggtcgtatcc gttgcggcaa ggtgtccgac 8640 aaggctcagt acctgctggg tgctgctggt tccgtgccct accgttggat caacctcgag 8700 tacgacaaga tcacccgtat cgtgggcctg gaccagtacc tcgagtccgt gaagaagcac 8760 aagcgtctgg acgtgtgccg tgctaagatg ggttacatgc tgcagtaaaa gcttgtcgag 8820 aagtactaga ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa 8880 aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac 8940 ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 9000 aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat 9060 catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca aagcccgaaa 9120 ggaagctgag ttggctgctg tggctagctt tgtttaactt taagaaggag atacatctag 9180 accggaatat taatagatca tggagataat taaaatgata accatctcgc aaataaataa 9240 gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat tccggattat 9300 tcataccgtc ccaccatcgg gcgcggatcc gccaccatgc tgcgtctgct gctgcgtcac 9360 cacttccact gcctgctgct gtgcgctgtg tgggctaccc cctgcctggc ttccccttgg 9420 tccaccctga ccgctaacca gaacccctcc ccaccctggt ccaagctgac ctactccaag 9480 ccccacgacg ctgctacctt ctactgcccc ttcctgtacc catccccccc tcgttcccca 9540 ctgcagttct ccggtttcca gcgtgtgctg accggtcccg agtgccgtaa cgagactctg 9600 tacctgctgt acaaccgcga gggccagacc ctggtcgaga ggtcctccac ctgggtcaag 9660 aaggtcatct ggtacttgtc cggtcgtaac cagaccatcc tgcagcgtat gccccgtacc 9720 gcttccaagc cctccgacgg caacgtgcag atctccgtcg aggacgctaa gatcttcggt 9780 gctcacatgg tgcccaagca gaccaagctg ctgcgtttcg tggtcaacga cggcacccgt 9840 taccagatgt gcgtgatgaa gctcgagtcc tgggctcacg tgttccgtga ctactccgtg 9900 tccttccaag tgcgcctgac cttcaccgag gctaacaacc agacctacac cttctgcacc 9960 caccccaacc tgatcgtgta aaagcttgtc gagaagtact agaggatcat aatcagccat 10020 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 10080 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 10140 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 10200 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 10260 cctagaagat ccggctgcta acaaagcccg aaaggaagct gagttggctg ctgggtgcct 10320 aatgagtgag ctaactcaca ttaattgccc ggaatattaa tagatcatgg agataattaa 10380 aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag ttttgtaata 10440 aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg cggatccgcc 10500 accatgcgtc tgtgccgtgt gtggctgtcc gtgtgcctgt gcgctgtggt gctgggccag 10560 tgccagcgtg aaaccgctga gaagaacgac tactaccgtg tgccccacta ctgggacgct 10620 tgctcccgtg ctctgcccga ccagacccgt tacaagtacg tcgagcagct ggtggacctg 10680 accctgaact accactacga cgcttcccac ggcctggaca acttcgacgt gctgaagcgt 10740 atcaacgtga ccgaggtgtc cctgctgatc tccgacttcc gtcgtcagaa ccgtcgtggt 10800 ggcaccaaca agcgtaccac cttcaacgct gctggttccc tggctcccca cgctcgttcc 10860 ctcgagttct ccgtgcgtct gttcgctaac taaaagcttg tcgagaagta ctagaggatc 10920 ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc 10980 cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct 11040 tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 11100 ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga 11160 tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc 11220 tgctgccacc gctgagcaat aactatcata acccctagga gatccgaacc agataagtga 11280 aatctagttc caaactattt tgtcattttt aattttcgta ttagcttacg acgctacacc 11340 cagttcccat ctattttgtc actcttccct aaataatcct taaaaactcc atttccaccc 11400 ctcccagttc ccaactattt tgtccgccca ca 11432 <210> 15 <211> 11338 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 15 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgctaaggc 4440 gccaagcttt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 4500 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 4560 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 4620 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 4680 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 4740 ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactatcat 4800 aacccctagg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat 4860 ccggatctga acaggaggga cagctgatag aaacagaagc cactggagca cctcaaaaac 4920 accatcatac actaaatcag taagttggca gcatcacccg acgcactttg cgccgaataa 4980 atacctgtga cggaagatca cttcgcagaa taaataaatc ctggtgtccc tgttgatacc 5040 gggaagccct gggccaactt ttggcgaaaa tgagacgttg atcggcacgt aagaggttcc 5100 aactttcacc ataatgaaat aagatcacta ccgggcgtat tttttgagtt atcgagattt 5160 tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac cgttgatata 5220 tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca atgtacctat 5280 aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa aaataagcac 5340 aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca tccggaattc 5400 cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc ttgttacacc 5460 gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca cgacgatttc 5520 cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa cctggcctat 5580 ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg ggtgagtttc 5640 accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt tttcaccatg 5700 ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca ggttcatcat 5760 gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca gtactgcgat 5820 gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta aacgcctggt 5880 tgctacgcct gaataagtga taataagcgg atgaatggca gaaattcgaa agcaaattcg 5940 acccggtcgt cggttcaggg cagggtcgtt aaatagccgc ttatgtctat tgctggttta 6000 ccggtttatt gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc tgaggccagt 6060 ttgctcaggc tctccccgtg gaggtaataa ttgacgatat gatcatttat tctgcctccc 6120 agctgacatt catccggggt cagcaccgtt tctgcggact ggctttctac gtgttccgct 6180 tcctttagca gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat tctgtcagcc 6240 gttaagtgtt cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg 6300 ttacatccct ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat 6360 attctttttt ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat 6420 taattttatt gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag 6480 ccatgagagc ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta 6540 cgttaaacat gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt 6600 tgaactgctg atcaacagat cctctacgcg gccgcggtac cataacttcg tatagcatac 6660 attatacgaa gttatctggt ttaaacgtac ccgtagtggc tatggcaggg cttgccgccc 6720 cgacgttggc tgcgagccct gggccttcac ccgaacttgg gggttggggt ggggaaaagg 6780 aagaaacgcg ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca gagtgccagc 6840 cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt tttattctgt 6900 ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg tgtttcagtt 6960 agcctccccc atctcccggt accgcatgct atgcatcagc tgctagctta gcgagcgtcc 7020 acagcctggg gaccgtaacg ggagtgagcg ggcaggttca cacgggtctg cttcagctca 7080 gggggcaggc cagcgtagta cttgtccagg tgacgcagca ggggggggtc cagctggtga 7140 cgcaggcaga attccttcac agcgttgtac aggccgtaga acagggtgat accctcggga 7200 gcagcagcgg tggacacggg cagacgcaca gcacggttgg tacgggtagc ctcgttacgg 7260 atagccacca ccacgttgaa cagggagggg ggcaccagct cgaaacccag cacgtgttcg 7320 gtgaagatgg aacgaccgta ggacagacga gtcaggtcgt aaccacggca caggtcgtcc 7380 acgcaagtgt acacagcggg ggaaccgtcg ccgcactcgg agtaaccgcg catcacggtc 7440 atccaacggg gagcggtgtc ggaggacagc agggtcagca gagcacgcag ctggtcgggg 7500 ttgttgtaca gcagggccag ggtgtccagg aaagcgtcgt ccagcagcac ggagttagca 7560 gcctcggggg tcacgggacg gtaacggatc agctgggaca ggggaccgtc cctacgggtc 7620 acgttgacca ggggacgcag ccaggactcg tacttgtcgc cctggaacac ctctcccagc 7680 aggcaacgac gggtcagctc ggggcactca gcgggcacct tctcagccac ggtgggagcc 7740 acggacacgg tagcggagga cacgatgggc agcagcaggc agcaccacag cagagccacg 7800 ggaccggggg agaaggagaa accgcagtcg ggacgacggc acatggtggc tcgagatccc 7860 gggtgatcaa gtcttcgtcg agtgattgta aataaaatgt aatttacagt atagtatttt 7920 aattaatata caaatgattt gataataatt cttatttaac tataatatat tgtgttgggt 7980 tgaattaaag gtccgtatac tagtatcgat tcgcgaccta ctccggaata ttaatagatc 8040 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 8100 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 8160 ggcgcggatc cgccaccatg tcccccaaga acctgacccc cttcctgacc gctctgtggc 8220 tgctgctggg ccactcccgt gtgcctcgtg tgcgtgctga ggaatgctgc gagttcatca 8280 acgtgaacca cccccccgag cgctgctacg acttcaagat gtgcaaccgt ttcaccgtgg 8340 ctctgcgttg ccccgacggc gaagtgtgct actcccccga aaagaccgct gagatccgtg 8400 gtatcgtgac caccatgacc cactccctga cccgtcaggt ggtgcacaac aagctgacct 8460 cttgcaacta caaccccctg tacctcgagg ctgacggtcg tatccgttgc ggcaaggtca 8520 acgacaaggc tcagtacctg ctgggtgctg ctggttccgt gccctaccgt tggatcaacc 8580 tcgagtacga caagatcacc cgtatcgtgg gcctggacca gtacctcgag tccgtgaaga 8640 agcacaagcg tctggacgtg tgccgtgcta agatgggtta catgctgcag taaaagcttg 8700 tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 8760 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 8820 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 8880 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 8940 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9000 cgaaaggaag ctgagttggc tgctgtggct agctttgttt aactttaaga aggagataca 9060 tctagaccgg aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata 9120 aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg 9180 attattcata ccgtcccacc atcgggcgcg gatccgccac catgctgcgt ctgctgctgc 9240 gtcaccactt ccactgcctg ctgctgtgcg ctgtgtgggc taccccctgc ctggcttccc 9300 cctggttcac cctgaccgct aaccagaacc cctccccacc ctggtccaag ctgacctacc 9360 ccaagcccca cgacgctgct accttctact gccccttcct gtacccatcc ccacctcgtt 9420 ccccatccca gttctccggt ttccagcgtg tgtccaccgg tcccgagtgc cgtaacgaga 9480 ctctgtacct gctgtacaac cgcgagggcc agaccctggt cgagaggtcc tccacctggg 9540 tcaagaaggt catctggtac ttgtccggtc gtaaccagac catcctgcag cgtatgcccc 9600 gtaccgcttc caagccctcc gacggcaacg tgcagatctc cgtcgaggac gctaagatct 9660 tcggtgctca catggtgccc aagcagacca agctgctgcg tttcgtggtc aacgacggca 9720 cccgttacca gatgtgcgtg atgaagctgg aatcctgggc tcacgtgttc cgtgactact 9780 ccgtgtcctt ccaagtgcgc ctgaccttca ccgaggctaa caaccagacc tacaccttct 9840 gcacccaccc caacctgatc gtgtaagtcg acaagcttgt cgagaagtac tagaggatca 9900 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 9960 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 10020 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 10080 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 10140 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 10200 gctgggtgcc taatgagtga gctaactcac attaattgcc cggaatatta atagatcatg 10260 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 10320 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 10380 gcggatccgc caccggatcc gccaccatgc gtctgtgccg tgtgtggctg tccgtgtgcc 10440 tgtgcgctgt ggtgctggga cagtgccagc gtgaaaccgc tgagaagaac gactactacc 10500 gtgtgcccca ctactgggac gcttgctccc gtgctctgcc cgaccagacc cgttacaagt 10560 acgtcgagca gctggtggac ctgaccctga actaccacta cgacgcttcc cacggcctgg 10620 acaacttcga cgtgctgaag cgtatcaacg tgaccgaggt gtccctgctg atctccgact 10680 tccgtcgtca gaaccgtcgt ggtggcacca acaagcgtac caccttcaac gctgctggtt 10740 ccctggctcc ccacgctcgt tccttggagt tctccgtgcg tctgttcgcc aactaataaa 10800 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 10860 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 10920 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 10980 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 11040 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 11100 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccc 11160 ctaggagatc cgaaccagat aagtgaaatc tagttccaaa ctattttgtc atttttaatt 11220 ttcgtattag cttacgacgc tacacccagt tcccatctat tttgtcactc ttccctaaat 11280 aatccttaaa aactccattt ccacccctcc cagttcccaa ctattttgtc cgcccaca 11338 <210> 16 <211> 11338 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 16 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgctaaggc 4440 gccaagcttt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 4500 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 4560 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 4620 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 4680 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 4740 ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactatcat 4800 aacccctagg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat 4860 ccggatctga acaggaggga cagctgatag aaacagaagc cactggagca cctcaaaaac 4920 accatcatac actaaatcag taagttggca gcatcacccg acgcactttg cgccgaataa 4980 atacctgtga cggaagatca cttcgcagaa taaataaatc ctggtgtccc tgttgatacc 5040 gggaagccct gggccaactt ttggcgaaaa tgagacgttg atcggcacgt aagaggttcc 5100 aactttcacc ataatgaaat aagatcacta ccgggcgtat tttttgagtt atcgagattt 5160 tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac cgttgatata 5220 tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca atgtacctat 5280 aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa aaataagcac 5340 aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca tccggaattc 5400 cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc ttgttacacc 5460 gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca cgacgatttc 5520 cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa cctggcctat 5580 ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg ggtgagtttc 5640 accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt tttcaccatg 5700 ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca ggttcatcat 5760 gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca gtactgcgat 5820 gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta aacgcctggt 5880 tgctacgcct gaataagtga taataagcgg atgaatggca gaaattcgaa agcaaattcg 5940 acccggtcgt cggttcaggg cagggtcgtt aaatagccgc ttatgtctat tgctggttta 6000 ccggtttatt gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc tgaggccagt 6060 ttgctcaggc tctccccgtg gaggtaataa ttgacgatat gatcatttat tctgcctccc 6120 agctgacatt catccggggt cagcaccgtt tctgcggact ggctttctac gtgttccgct 6180 tcctttagca gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat tctgtcagcc 6240 gttaagtgtt cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg 6300 ttacatccct ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat 6360 attctttttt ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat 6420 taattttatt gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag 6480 ccatgagagc ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta 6540 cgttaaacat gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt 6600 tgaactgctg atcaacagat cctctacgcg gccgcggtac cataacttcg tatagcatac 6660 attatacgaa gttatctggt ttaaacgtac ccgtagtggc tatggcaggg cttgccgccc 6720 cgacgttggc tgcgagccct gggccttcac ccgaacttgg gggttggggt ggggaaaagg 6780 aagaaacgcg ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca gagtgccagc 6840 cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt tttattctgt 6900 ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg tgtttcagtt 6960 agcctccccc atctcccggt accgcatgct atgcatcagc tgctagctta gcgagcgtcc 7020 acagcctggg gaccgtaacg ggagtgagcg ggcaggttca cacgggtctg cttcagctca 7080 gggggcaggc cagcgtagta cttgtccagg tgacgcagca ggggggggtc cagctggtga 7140 cgcaggcaga attccttcac agcgttgtac aggccgtaga acagggtgat accctcggga 7200 gcagcagcgg tggacacggg cagacgcaca gcacggttgg tacgggtagc ctcgttacgg 7260 atagccacca ccacgttgaa cagggagggg ggcaccagct cgaaacccag cacgtgttcg 7320 gtgaagatgg aacgaccgta ggacagacga gtcaggtcgt aaccacggca caggtcgtcc 7380 acgcaagtgt acacagcggg ggaaccgtcg ccgcactcgg agtaaccgcg catcacggtc 7440 atccaacggg gagcggtgtc ggaggacagc agggtcagca gagcacgcag ctggtcgggg 7500 ttgttgtaca gcagggccag ggtgtccagg aaagcgtcgt ccagcagcac ggagttagca 7560 gcctcggggg tcacgggacg gtaacggatc agctgggaca ggggaccgtc cctacgggtc 7620 acgttgacca ggggacgcag ccaggactcg tacttgtcgc cctggaacac ctctcccagc 7680 aggcaacgac gggtcagctc ggggcactca gcgggcacct tctcagccac ggtgggagcc 7740 acggacacgg tagcggagga cacgatgggc agcagcaggc agcaccacag cagagccacg 7800 ggaccggggg agaaggagaa accgcagtcg ggacgacggc acatggtggc tcgagatccc 7860 gggtgatcaa gtcttcgtcg agtgattgta aataaaatgt aatttacagt atagtatttt 7920 aattaatata caaatgattt gataataatt cttatttaac tataatatat tgtgttgggt 7980 tgaattaaag gtccgtatac tagtatcgat tcgcgaccta ctccggaata ttaatagatc 8040 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 8100 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 8160 ggcgcggatc cgccaccatg aactccaagg acctgacccc cttcctgacc accctgtggc 8220 tgctgctgga ccactcccgt gtgcctcgtg tgcgtgctga ggaatgctgc gaagtgatca 8280 acgtgaacca cccccccgag cgctgctacg acttcaagat gtgcaacctg ttcaccgtgg 8340 ctctgcgttg ccccgacggc gaagtgtgct actcccccga aaagaccgct gagatccgtg 8400 gtatcgtgac caccatgacc cactccctga cccgtcaagt gatccacaac aagctgacca 8460 gctgcaacta caaccccctg tacctcgagg ctgacggtcg tatccgttgc ggcaaggtgt 8520 ccgacaaggc tcagtacctg ctgggtgctg ctggttccgt gccctaccgt tggatcaacc 8580 tcgagtacga caagatcacc cgtatcgtgg gcctggacca gtacctcgag tccgtgaaga 8640 agcacaagcg tctggacgtg tgccgtgcta agatgggtta catgctgcag taaaagcttg 8700 tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 8760 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 8820 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 8880 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 8940 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9000 cgaaaggaag ctgagttggc tgctgtggct agctttgttt aactttaaga aggagataca 9060 tctagaccgg aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata 9120 aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg 9180 attattcata ccgtcccacc atcgggcgcg gatccgccac catgctgcgt ctgctgctgc 9240 gtcaccactt ccactgcctg ctgctgtgcg ctgtgtgggc taccccctgc ctggcttccc 9300 cctggttcac cctgaccgct aaccagaacc cctccccacc ctggtccaag ctgacctacc 9360 ccaagcccca cgacgctgct accttctact gccccttcct gtacccatcc ccacctcgtt 9420 ccccatccca gttctccggt ttccagcgtg tgtccaccgg tcccgagtgc cgtaacgaga 9480 ctctgtacct gctgtacaac cgcgagggcc agaccctggt cgagaggtcc tccacctggg 9540 tcaagaaggt catctggtac ttgtccggtc gtaaccagac catcctgcag cgtatgcccc 9600 gtaccgcttc caagccctcc gacggcaacg tgcagatctc cgtcgaggac gctaagatct 9660 tcggtgctca catggtgccc aagcagacca agctgctgcg tttcgtggtc aacgacggca 9720 cccgttacca gatgtgcgtg atgaagctgg aatcctgggc tcacgtgttc cgtgactact 9780 ccgtgtcctt ccaagtgcgc ctgaccttca ccgaggctaa caaccagacc tacaccttct 9840 gcacccaccc caacctgatc gtgtaagtcg acaagcttgt cgagaagtac tagaggatca 9900 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 9960 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 10020 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 10080 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 10140 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 10200 gctgggtgcc taatgagtga gctaactcac attaattgcc cggaatatta atagatcatg 10260 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 10320 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 10380 gcggatccgc caccggatcc gccaccatgc gtctgtgccg tgtgtggctg tccgtgtgcc 10440 tgtgcgctgt ggtgctggga cagtgccagc gtgaaaccgc tgagaagaac gactactacc 10500 gtgtgcccca ctactgggac gcttgctccc gtgctctgcc cgaccagacc cgttacaagt 10560 acgtcgagca gctggtggac ctgaccctga actaccacta cgacgcttcc cacggcctgg 10620 acaacttcga cgtgctgaag cgtatcaacg tgaccgaggt gtccctgctg atctccgact 10680 tccgtcgtca gaaccgtcgt ggtggcacca acaagcgtac caccttcaac gctgctggtt 10740 ccctggctcc ccacgctcgt tccttggagt tctccgtgcg tctgttcgcc aactaataaa 10800 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 10860 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 10920 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 10980 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 11040 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 11100 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccc 11160 ctaggagatc cgaaccagat aagtgaaatc tagttccaaa ctattttgtc atttttaatt 11220 ttcgtattag cttacgacgc tacacccagt tcccatctat tttgtcactc ttccctaaat 11280 aatccttaaa aactccattt ccacccctcc cagttcccaa ctattttgtc cgcccaca 11338 <210> 17 <211> 9952 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 17 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttag cgagcgtcca cagcctgggg accgtaacgg gagtgagcgg 2400 gcaggttcac acgggtctgc ttcagctcag ggggcaggcc agcgtagtac ttgtccaggt 2460 gacgcagcag gggggggtcc agctggtgac gcaggcagaa ttccttcaca gcgttgtaca 2520 ggccgtagaa cagggtgata ccctcgggag cagcagcggt ggacacgggc agacgcacag 2580 cacggttggt acgggtagcc tcgttacgga tagccaccac cacgttgaac agggaggggg 2640 gcaccagctc gaaacccagc acgtgttcgg tgaagatgga acgaccgtag gacagacgag 2700 tcaggtcgta accacggcac aggtcgtcca cgcaagtgta cacagcgggg gaaccgtcgc 2760 cgcactcgga gtaaccgcgc atcacggtca tccaacgggg agcggtgtcg gaggacagca 2820 gggtcagcag agcacgcagc tggtcggggt tgttgtacag cagggccagg gtgtccagga 2880 aagcgtcgtc cagcagcacg gagttagcag cctcgggggt cacgggacgg taacggatca 2940 gctgggacag gggaccgtcc ctacgggtca cgttgaccag gggacgcagc caggactcgt 3000 acttgtcgcc ctggaacacc tctcccagca ggcaacgacg ggtcagctcg gggcactcag 3060 cgggcacctt ctcagccacg gtgggagcca cggacacggt agcggaggac acgatgggca 3120 gcagcaggca gcaccacagc agagccacgg gaccggggga gaaggagaaa ccgcagtcgg 3180 gacgacggca catggtggct cgagatcccg ggtgatcaag tcttcgtcga gtgattgtaa 3240 ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg ataataattc 3300 ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact agtatcgatt 3360 cgcgacctac tccggaatat taatagatca tggagataat taaaatgata accatctcgc 3420 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 3480 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgt cccccaagaa 3540 cctgaccccc ttcctgaccg ctctgtggct gctgctgggc cactcccgtg tgcctcgtgt 3600 gcgtgctgag gaatgctgcg agttcatcaa cgtgaaccac ccccccgagc gctgctacga 3660 cttcaagatg tgcaaccgtt tcaccgtggc tctgcgttgc cccgacggcg aagtgtgcta 3720 ctcccccgaa aagaccgctg agatccgtgg tatcgtgacc accatgaccc actccctgac 3780 ccgtcaggtg gtgcacaaca agctgacctc ttgcaactac aaccccctgt acctcgaggc 3840 tgacggtcgt atccgttgcg gcaaggtcaa cgacaaggct cagtacctgc tgggtgctgc 3900 tggttccgtg ccctaccgtt ggatcaacct cgagtacgac aagatcaccc gtatcgtggg 3960 cctggaccag tacctcgagt ccgtgaagaa gcacaagcgt ctggacgtgt gccgtgctaa 4020 gatgggttac atgctgcagt aaaagcttgt cgagaagtac tagaggatca taatcagcca 4080 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 4140 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 4200 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4260 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 4320 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 4380 gctttgttta actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga 4440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 4500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 4560 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 4620 tgtgtgggct accccctgcc tggcttcccc ttggtccacc ctgaccgcta accagaaccc 4680 ctccccaccc tggtccaagc tgacctactc caagccccac gacgctgcta ccttctactg 4740 ccccttcctg tacccatccc cccctcgttc cccactgcag ttctccggtt tccagcgtgt 4800 gctgaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 4860 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 4920 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 4980 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 5040 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctcga 5100 gtcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 5160 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaaaagct 5220 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 5280 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 5340 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 5400 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 5460 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 5520 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 5580 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 5640 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 5700 ttcataccgt cccaccatcg ggcgcggatc cgccaccatg cgtctgtgcc gtgtgtggct 5760 gtccgtgtgc ctgtgcgctg tggtgctggg ccagtgccag cgtgaaaccg ctgagaagaa 5820 cgactactac cgtgtgcccc actactggga cgcttgctcc cgtgctctgc ccgaccagac 5880 ccgttacaag tacgtcgagc agctggtgga cctgaccctg aactaccact acgacgcttc 5940 ccacggcctg gacaacttcg acgtgctgaa gcgtatcaac gtgaccgagg tgtccctgct 6000 gatctccgac ttccgtcgtc agaaccgtcg tggtggcacc aacaagcgta ccaccttcaa 6060 cgctgctggt tccctggctc cccacgctcg ttccctcgag ttctccgtgc gtctgttcgc 6120 taactaaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 6180 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 6240 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 6300 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 6360 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 6420 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 6480 cataaccccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 6540 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 6600 ggattattca taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattca 6660 aaggcctacc gtcgacgcca ccatggaatc ccgtatctgg tgcctggtcg tgtgcgtgaa 6720 cctgtgcatc gtgtgcctgg gtgctgctgt gtcctcctcc tccacccgtg gcacctccgc 6780 tacccactcc caccactcct cccacaccac ctccgccgct cactcccgtt ccggttccgt 6840 gtcccagcgt gtgacctcct cccagaccgt gtcccacggt gtcaacgaga ctatctacaa 6900 caccaccctg aagtacggcg acgtcgtggg tgtcaacacc accaagtacc cctaccgtgt 6960 gtgctccatg gctcagggca ccgacctgat ccgtttcgag cgtaacatcg tgtgcacctc 7020 catgaagccc atcaacgagg acctggacga gggtatcatg gtggtgtaca agcgcaacat 7080 cgtggctcac accttcaagg tccgcgtgta ccagaaggtg ctgaccttcc gtcgttccta 7140 cgcttacatc cacaccactt acctgctggg ttccaacacc gagtacgtgg cccctcccat 7200 gtgggagatc caccacatca actcccactc ccagtgctac tcctcttact cccgtgtgat 7260 cgctggcacc gtgttcgtgg cttaccaccg tgactcctac gagaacaaga ccatgcagct 7320 gatgcccgac gactactcca acacccactc cacccgttac gtgaccgtga aggaccagtg 7380 gcactcccgt ggttccacct ggctgtaccg tgaaacctgc aacctgaact gcatggtcac 7440 catcaccacc gctcgttcca agtaccctta ccacttcttc gctacctcca ccggcgacgt 7500 ggtggacatc tcccccttct acaacggtac taaccgtaac gcttcctact tcggcgagaa 7560 cgctgacaag ttcttcatct tccccaacta caccatcgtg tccgacttcg gtcgtcccaa 7620 ctccgctctg gaaacccacc gtctggtggc tttcttggag cgtgctgact ccgtgatctc 7680 ctgggacatc caggacgaga agaacgtgac ctgccagctg accttctggg aggcttccga 7740 gcgtaccatc cgttccgagg ctgaggactc ctaccacttc tccagcgcta agatgaccgc 7800 taccttcctg tccaagaaac aagaggtcaa catgtccgac tccgccctgg actgcgtgcg 7860 tgacgaggct atcaacaagc tgcagcagat cttcaacacc tcctacaacc agacctacga 7920 gaagtacgga aacgtgtccg tgttcgagac taccggtggc ctggtggtgt tctggcaggg 7980 tatcaagcag aagtccctgg tcgagctgga acgtctggct aaccgttcct ccctgaacct 8040 gacccacaac cgtaccaagc gttccaccga cggcaacaac gctactcacc tgtccaacat 8100 ggaatccgtg cacaacctgg tgtacgctca gctgcagttc acctacgaca ccctgcgcgg 8160 ttacatcaac cgtgctctgg ctcagatcgc tgaggcttgg tgcgtggacc agcgtcgtac 8220 cctggaagtg ttcaaggaac tgtccaagat caacccctcc gctatcctgt ccgccatcta 8280 caacaagcct atcgctgctc gtttcatggg cgacgtgctg ggcctggctt cctgcgtgac 8340 catcaaccag acttccgtga aggtgctgcg tgacatgaac gtgaaggaat cccccggtcg 8400 ttgctactcc cgtcccgtgg tcatcttcaa cttcgctaac tcctcctacg tgcagtacgg 8460 ccagctgggc gaggacaacg agatcctgct gggcaaccac cgtaccgagg aatgccagct 8520 gccctccctg aagatcttca tcgctggcaa ctccgcttac gaatacgtgg actacctgtt 8580 caagcgcatg atcgacctgt cctccatctc taccgtggac tccatgatcg ctctggacat 8640 cgaccccctg gaaaacaccg acttccgtgt gctggaactg tactcccaga aggaactgcg 8700 ttccatcaac gtgttcgacc tggaagagat catgcgcgag ttcaactcct acaagcagcg 8760 tgttaagtac gtcgaggaca aggtggtgga ccccctgccc ccctacctga agggactgga 8820 cgacctgatg tccggcctgg gagctgccgg caaggctgtg ggtgtcgcta tcggtgctgt 8880 gggtggtgct gtggcttccg tggtcgaggg tgtcgccacc ttcctgaaga accccttcgg 8940 tgctttcacc atcatcctgg tggctatcgc tgtggtcatc atcatctacc tgatctacac 9000 ccgtcagcgt cgtctgtgca tgcagcccct gcagaacctg ttcccctacc tggtgtccgc 9060 tgacggtact accgtgacct ccggcaacac caaggacacc tccctgcagg ctcccccatc 9120 ctacgaggaa tccgtctaca actccggtcg caagggtccc ggtccccctt cctccgacgc 9180 ttctaccgct gctcccccat acaccaacga gcaggcttac cagatgctgc tggctctcgt 9240 gcgtctggac gctgagcagc gtgcacagca gaacggcacc gactccctgg acggccagac 9300 cggaacccag gacaagggcc agaagcccaa cctgctggac cgtctgcgtc accgcaagaa 9360 cggttaccgt cacctgaagg actccgacga ggaagagaac gtctaaggcg cgccaagctt 9420 gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 9480 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 9540 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 9600 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 9660 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9720 cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactatcata acccctagga 9780 gatccgaacc agataagtga aatctagttc caaactattt tgtcattttt aattttcgta 9840 ttagcttacg acgctacacc cagttcccat ctattttgtc actcttccct aaataatcct 9900 taaaaactcc atttccaccc ctcccagttc ccaactattt tgtccgccca ca 9952 <210> 18 <211> 12658 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 18 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttag cgagcgtcca cagcctgggg accgtaacgg gagtgagcgg 2400 gcaggttcac acgggtctgc ttcagctcag ggggcaggcc agcgtagtac ttgtccaggt 2460 gacgcagcag gggggggtcc agctggtgac gcaggcagaa ttccttcaca gcgttgtaca 2520 ggccgtagaa cagggtgata ccctcgggag cagcagcggt ggacacgggc agacgcacag 2580 cacggttggt acgggtagcc tcgttacgga tagccaccac cacgttgaac agggaggggg 2640 gcaccagctc gaaacccagc acgtgttcgg tgaagatgga acgaccgtag gacagacgag 2700 tcaggtcgta accacggcac aggtcgtcca cgcaagtgta cacagcgggg gaaccgtcgc 2760 cgcactcgga gtaaccgcgc atcacggtca tccaacgggg agcggtgtcg gaggacagca 2820 gggtcagcag agcacgcagc tggtcggggt tgttgtacag cagggccagg gtgtccagga 2880 aagcgtcgtc cagcagcacg gagttagcag cctcgggggt cacgggacgg taacggatca 2940 gctgggacag gggaccgtcc ctacgggtca cgttgaccag gggacgcagc caggactcgt 3000 acttgtcgcc ctggaacacc tctcccagca ggcaacgacg ggtcagctcg gggcactcag 3060 cgggcacctt ctcagccacg gtgggagcca cggacacggt agcggaggac acgatgggca 3120 gcagcaggca gcaccacagc agagccacgg gaccggggga gaaggagaaa ccgcagtcgg 3180 gacgacggca catggtggct cgagatcccg ggtgatcaag tcttcgtcga gtgattgtaa 3240 ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg ataataattc 3300 ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact agtatcgatt 3360 cgcgacctac tccggaatat taatagatca tggagataat taaaatgata accatctcgc 3420 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 3480 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgt cccccaagaa 3540 cctgaccccc ttcctgaccg ctctgtggct gctgctgggc cactcccgtg tgcctcgtgt 3600 gcgtgctgag gaatgctgcg agttcatcaa cgtgaaccac ccccccgagc gctgctacga 3660 cttcaagatg tgcaaccgtt tcaccgtggc tctgcgttgc cccgacggcg aagtgtgcta 3720 ctcccccgaa aagaccgctg agatccgtgg tatcgtgacc accatgaccc actccctgac 3780 ccgtcaggtg gtgcacaaca agctgacctc ttgcaactac aaccccctgt acctcgaggc 3840 tgacggtcgt atccgttgcg gcaaggtcaa cgacaaggct cagtacctgc tgggtgctgc 3900 tggttccgtg ccctaccgtt ggatcaacct cgagtacgac aagatcaccc gtatcgtggg 3960 cctggaccag tacctcgagt ccgtgaagaa gcacaagcgt ctggacgtgt gccgtgctaa 4020 gatgggttac atgctgcagt aaaagcttgt cgagaagtac tagaggatca taatcagcca 4080 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 4140 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 4200 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4260 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 4320 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 4380 gctttgttta actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga 4440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 4500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 4560 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 4620 tgtgtgggct accccctgcc tggcttcccc ttggtccacc ctgaccgcta accagaaccc 4680 ctccccaccc tggtccaagc tgacctactc caagccccac gacgctgcta ccttctactg 4740 ccccttcctg tacccatccc cccctcgttc cccactgcag ttctccggtt tccagcgtgt 4800 gctgaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 4860 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 4920 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 4980 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 5040 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctcga 5100 gtcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 5160 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaaaagct 5220 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 5280 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 5340 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 5400 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 5460 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 5520 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 5580 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 5640 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 5700 ttcataccgt cccaccatcg ggcgcggatc cgccaccatg cgtctgtgcc gtgtgtggct 5760 gtccgtgtgc ctgtgcgctg tggtgctggg ccagtgccag cgtgaaaccg ctgagaagaa 5820 cgactactac cgtgtgcccc actactggga cgcttgctcc cgtgctctgc ccgaccagac 5880 ccgttacaag tacgtcgagc agctggtgga cctgaccctg aactaccact acgacgcttc 5940 ccacggcctg gacaacttcg acgtgctgaa gcgtatcaac gtgaccgagg tgtccctgct 6000 gatctccgac ttccgtcgtc agaaccgtcg tggtggcacc aacaagcgta ccaccttcaa 6060 cgctgctggt tccctggctc cccacgctcg ttccctcgag ttctccgtgc gtctgttcgc 6120 taactaaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 6180 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 6240 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 6300 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 6360 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 6420 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 6480 cataaccccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 6540 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 6600 ggattattca taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattca 6660 aaggcctacc gtcgacgcca ccatggaatc ccgtatctgg tgcctggtcg tgtgcgtgaa 6720 cctgtgcatc gtgtgcctgg gtgctgctgt gtcctcctcc tccacccgtg gcacctccgc 6780 tacccactcc caccactcct cccacaccac ctccgccgct cactcccgtt ccggttccgt 6840 gtcccagcgt gtgacctcct cccagaccgt gtcccacggt gtcaacgaga ctatctacaa 6900 caccaccctg aagtacggcg acgtcgtggg tgtcaacacc accaagtacc cctaccgtgt 6960 gtgctccatg gctcagggca ccgacctgat ccgtttcgag cgtaacatcg tgtgcacctc 7020 catgaagccc atcaacgagg acctggacga gggtatcatg gtggtgtaca agcgcaacat 7080 cgtggctcac accttcaagg tccgcgtgta ccagaaggtg ctgaccttcc gtcgttccta 7140 cgcttacatc cacaccactt acctgctggg ttccaacacc gagtacgtgg cccctcccat 7200 gtgggagatc caccacatca actcccactc ccagtgctac tcctcttact cccgtgtgat 7260 cgctggcacc gtgttcgtgg cttaccaccg tgactcctac gagaacaaga ccatgcagct 7320 gatgcccgac gactactcca acacccactc cacccgttac gtgaccgtga aggaccagtg 7380 gcactcccgt ggttccacct ggctgtaccg tgaaacctgc aacctgaact gcatggtcac 7440 catcaccacc gctcgttcca agtaccctta ccacttcttc gctacctcca ccggcgacgt 7500 ggtggacatc tcccccttct acaacggtac taaccgtaac gcttcctact tcggcgagaa 7560 cgctgacaag ttcttcatct tccccaacta caccatcgtg tccgacttcg gtcgtcccaa 7620 ctccgctctg gaaacccacc gtctggtggc tttcttggag cgtgctgact ccgtgatctc 7680 ctgggacatc caggacgaga agaacgtgac ctgccagctg accttctggg aggcttccga 7740 gcgtaccatc cgttccgagg ctgaggactc ctaccacttc tccagcgcta agatgaccgc 7800 taccttcctg tccaagaaac aagaggtcaa catgtccgac tccgccctgg actgcgtgcg 7860 tgacgaggct atcaacaagc tgcagcagat cttcaacacc tcctacaacc agacctacga 7920 gaagtacgga aacgtgtccg tgttcgagac taccggtggc ctggtggtgt tctggcaggg 7980 tatcaagcag aagtccctgg tcgagctgga acgtctggct aaccgttcct ccctgaacct 8040 gacccacaac cgtaccaagc gttccaccga cggcaacaac gctactcacc tgtccaacat 8100 ggaatccgtg cacaacctgg tgtacgctca gctgcagttc acctacgaca ccctgcgcgg 8160 ttacatcaac cgtgctctgg ctcagatcgc tgaggcttgg tgcgtggacc agcgtcgtac 8220 cctggaagtg ttcaaggaac tgtccaagat caacccctcc gctatcctgt ccgccatcta 8280 caacaagcct atcgctgctc gtttcatggg cgacgtgctg ggcctggctt cctgcgtgac 8340 catcaaccag acttccgtga aggtgctgcg tgacatgaac gtgaaggaat cccccggtcg 8400 ttgctactcc cgtcccgtgg tcatcttcaa cttcgctaac tcctcctacg tgcagtacgg 8460 ccagctgggc gaggacaacg agatcctgct gggcaaccac cgtaccgagg aatgccagct 8520 gccctccctg aagatcttca tcgctggcaa ctccgcttac gaatacgtgg actacctgtt 8580 caagcgcatg atcgacctgt cctccatctc taccgtggac tccatgatcg ctctggacat 8640 cgaccccctg gaaaacaccg acttccgtgt gctggaactg tactcccaga aggaactgcg 8700 ttccatcaac gtgttcgacc tggaagagat catgcgcgag ttcaactcct acaagcagcg 8760 tgttaagtac gtcgaggaca aggtggtgga ccccctgccc ccctacctga agggactgga 8820 cgacctgatg tccggcctgg gagctgccgg caaggctgtg ggtgtcgcta tcggtgctgt 8880 gggtggtgct gtggcttccg tggtcgaggg tgtcgccacc ttcctgaaga accccttcgg 8940 tgctttcacc atcatcctgg tggctatcgc tgtggtcatc atcatctacc tgatctacac 9000 ccgtcagcgt cgtctgtgca tgcagcccct gcagaacctg ttcccctacc tggtgtccgc 9060 tgacggtact accgtgacct ccggcaacac caaggacacc tccctgcagg ctcccccatc 9120 ctacgaggaa tccgtctaca actccggtcg caagggtccc ggtccccctt cctccgacgc 9180 ttctaccgct gctcccccat acaccaacga gcaggcttac cagatgctgc tggctctcgt 9240 gcgtctggac gctgagcagc gtgcacagca gaacggcacc gactccctgg acggccagac 9300 cggaacccag gacaagggcc agaagcccaa cctgctggac cgtctgcgtc accgcaagaa 9360 cggttaccgt cacctgaagg actccgacga ggaagagaac gtctaaggcg cgccaagctt 9420 gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 9480 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 9540 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 9600 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 9660 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9720 cgaaaggaag ctgggaatat taatagatca tggagataat taaaatgata accatctcgc 9780 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 9840 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgc gtcccggcct 9900 gccctcctac ctgatcgtgc tggctgtgtg cctgctgtcc cacctcctgt cctcccgtta 9960 cggtgctgag gctatctccg agcccctgga caaggctttc cacctcctgc tgaacaccta 10020 cggtcgtcct atccgtttcc tgcgcgagaa caccacccag tgcacctaca actcctccct 10080 gcgcaactcc accgtcgtcc gcgagaacgc tatctccttc aacttcttcc agtcctacaa 10140 ccagtactac gtgttccaca tgccccgttg cctgttcgct ggtcccctgg ctgagcagtt 10200 cctgaaccag gtggacctga ccgagactct cgagcgttac cagcagcgtc tgaacactta 10260 cgctctggtg tccaaggacc tggcttccta ccgttccttc agccagcagc tgaaggctca 10320 ggactccctg ggcgagcagc ccaccactgt gcctccccct atcgacctgt ccatccccca 10380 cgtgtggatg cccccccaga ccactcctca cggctggacc gagtcccaca ccacctccgg 10440 actgcaccgt ccccacttca accagacctg catcctgttc gacggtcacg acctgctgtt 10500 ctccaccgtg accccctgcc tgcaccaggg cttctacctc atcgacgagc tgcgttacgt 10560 gaagatcacc ctgaccgagg atttcttcgt ggtcaccgtg tccatcgacg acgacacccc 10620 catgctgctg atcttcggtc acctcccccg tgtgctgttc aaggctccct accagcgtga 10680 caacttcatc ctgcgtcaga ccgagaagca cgagctgctg gtgctggtca agaaggacca 10740 gctgaaccgt cactcttacc tgaaggaccc cgacttcctg gacgctgctc tggacttcaa 10800 ctacctggac ctgtccgctc tgctgaggaa ctccttccac cgttacgctg tggacgtgct 10860 gaagtccggt cgttgccaga tgctggaccg tcgtaccgtc gagatggctt tcgcttacgc 10920 cctggctctg ttcgctgctg ctcgtcaaga agaggctggc gctcaggtgt ccgtgccccg 10980 tgctctggac cgtcaggctg ctctgctgca gatccaagag ttcatgatca cttgcctgtc 11040 ccagaccccc cctcgtacca ccctgctgct gtaccccacc gctgtggacc tggctaagcg 11100 tgctctgtgg acccccaacc agatcaccga catcacctcc ctcgtgcgtc tggtgtacat 11160 cctgtccaag cagaaccagc agcacctgat cccccagtgg gctctgcgtc agatcgctga 11220 cttcgctctg aagctgcaca agacccacct ggcttcattc ctcagcgctt tcgctcgcca 11280 agagctgtac ctgatgggtt ccctggtgca ctccatgctg gtgcacacca ccgagcgtcg 11340 cgagatcttc atcgtggaaa ccggcctgtg ctccctggcc gagctgtccc acttcaccca 11400 gctgctggct cacccccacc acgagtacct gtccgacctg tacaccccct gctcctcttc 11460 cggtcgtcgt gaccactccc tggaacgtct gacccgtctg ttccccgacg ctaccgtgcc 11520 taccaccgtg cctgctgctc tgtccatcct gtctaccatg cagccctcca ccctggaaac 11580 cttccccgac ctgttctgcc tgcctctggg cgagtccttc tccgctctga ccgtgtccga 11640 gcacgtgtcc tacgtggtca ccaaccagta cctgatcaag ggcatctcct accccgtgtc 11700 caccaccgtc gtgggccagt ccctgatcat cacccagacc gactcccaga ccaagtgcga 11760 gctgacccgt aacatgcaca ccactcactc catcaccgct gctctgaaca tctccctcga 11820 gaactgcgct ttctgccagt ccgctctgtt ggagtacgac gacactcagg gtgtcatcaa 11880 catcatgtac atgcacgact ccgacgacgt gctgttcgct ctggacccct acaacgaggt 11940 ggtggtgtcc tccccccgta cccactacct gatgctgctg aagaacggca ccgtgctgga 12000 agtgaccgac gtggtggtgg acgctaccga ccgtctgctg atgatgtccg tgtacgctct 12060 gtccgctatc atcggcatct acctgctgta ccgtatgctg aagacctgct aaggcgccaa 12120 gctttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 12180 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 12240 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 12300 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 12360 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 12420 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccc 12480 ctaggagatc cgaaccagat aagtgaaatc tagttccaaa ctattttgtc atttttaatt 12540 ttcgtattag cttacgacgc tacacccagt tcccatctat tttgtcactc ttccctaaat 12600 aatccttaaa aactccattt ccacccctcc cagttcccaa ctattttgtc cgcccaca 12658 <210> 19 <211> 14914 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 19 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttag cgagcgtcca cagcctgggg accgtaacgg gagtgagcgg 2400 gcaggttcac acgggtctgc ttcagctcag ggggcaggcc agcgtagtac ttgtccaggt 2460 gacgcagcag gggggggtcc agctggtgac gcaggcagaa ttccttcaca gcgttgtaca 2520 ggccgtagaa cagggtgata ccctcgggag cagcagcggt ggacacgggc agacgcacag 2580 cacggttggt acgggtagcc tcgttacgga tagccaccac cacgttgaac agggaggggg 2640 gcaccagctc gaaacccagc acgtgttcgg tgaagatgga acgaccgtag gacagacgag 2700 tcaggtcgta accacggcac aggtcgtcca cgcaagtgta cacagcgggg gaaccgtcgc 2760 cgcactcgga gtaaccgcgc atcacggtca tccaacgggg agcggtgtcg gaggacagca 2820 gggtcagcag agcacgcagc tggtcggggt tgttgtacag cagggccagg gtgtccagga 2880 aagcgtcgtc cagcagcacg gagttagcag cctcgggggt cacgggacgg taacggatca 2940 gctgggacag gggaccgtcc ctacgggtca cgttgaccag gggacgcagc caggactcgt 3000 acttgtcgcc ctggaacacc tctcccagca ggcaacgacg ggtcagctcg gggcactcag 3060 cgggcacctt ctcagccacg gtgggagcca cggacacggt agcggaggac acgatgggca 3120 gcagcaggca gcaccacagc agagccacgg gaccggggga gaaggagaaa ccgcagtcgg 3180 gacgacggca catggtggct cgagatcccg ggtgatcaag tcttcgtcga gtgattgtaa 3240 ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg ataataattc 3300 ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact agtatcgatt 3360 cgcgacctac tccggaatat taatagatca tggagataat taaaatgata accatctcgc 3420 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 3480 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgt cccccaagaa 3540 cctgaccccc ttcctgaccg ctctgtggct gctgctgggc cactcccgtg tgcctcgtgt 3600 gcgtgctgag gaatgctgcg agttcatcaa cgtgaaccac ccccccgagc gctgctacga 3660 cttcaagatg tgcaaccgtt tcaccgtggc tctgcgttgc cccgacggcg aagtgtgcta 3720 ctcccccgaa aagaccgctg agatccgtgg tatcgtgacc accatgaccc actccctgac 3780 ccgtcaggtg gtgcacaaca agctgacctc ttgcaactac aaccccctgt acctcgaggc 3840 tgacggtcgt atccgttgcg gcaaggtcaa cgacaaggct cagtacctgc tgggtgctgc 3900 tggttccgtg ccctaccgtt ggatcaacct cgagtacgac aagatcaccc gtatcgtggg 3960 cctggaccag tacctcgagt ccgtgaagaa gcacaagcgt ctggacgtgt gccgtgctaa 4020 gatgggttac atgctgcagt aaaagcttgt cgagaagtac tagaggatca taatcagcca 4080 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 4140 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 4200 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4260 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 4320 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 4380 gctttgttta actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga 4440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 4500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 4560 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 4620 tgtgtgggct accccctgcc tggcttcccc ttggtccacc ctgaccgcta accagaaccc 4680 ctccccaccc tggtccaagc tgacctactc caagccccac gacgctgcta ccttctactg 4740 ccccttcctg tacccatccc cccctcgttc cccactgcag ttctccggtt tccagcgtgt 4800 gctgaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 4860 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 4920 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 4980 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 5040 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctcga 5100 gtcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 5160 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaaaagct 5220 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 5280 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 5340 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 5400 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 5460 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 5520 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 5580 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 5640 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 5700 ttcataccgt cccaccatcg ggcgcggatc cgccaccatg cgtctgtgcc gtgtgtggct 5760 gtccgtgtgc ctgtgcgctg tggtgctggg ccagtgccag cgtgaaaccg ctgagaagaa 5820 cgactactac cgtgtgcccc actactggga cgcttgctcc cgtgctctgc ccgaccagac 5880 ccgttacaag tacgtcgagc agctggtgga cctgaccctg aactaccact acgacgcttc 5940 ccacggcctg gacaacttcg acgtgctgaa gcgtatcaac gtgaccgagg tgtccctgct 6000 gatctccgac ttccgtcgtc agaaccgtcg tggtggcacc aacaagcgta ccaccttcaa 6060 cgctgctggt tccctggctc cccacgctcg ttccctcgag ttctccgtgc gtctgttcgc 6120 taactaaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 6180 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 6240 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 6300 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 6360 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 6420 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 6480 cataaccccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 6540 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 6600 ggattattca taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattca 6660 aaggcctacc gtcgacgcca ccatggaatc ccgtatctgg tgcctggtcg tgtgcgtgaa 6720 cctgtgcatc gtgtgcctgg gtgctgctgt gtcctcctcc tccacccgtg gcacctccgc 6780 tacccactcc caccactcct cccacaccac ctccgccgct cactcccgtt ccggttccgt 6840 gtcccagcgt gtgacctcct cccagaccgt gtcccacggt gtcaacgaga ctatctacaa 6900 caccaccctg aagtacggcg acgtcgtggg tgtcaacacc accaagtacc cctaccgtgt 6960 gtgctccatg gctcagggca ccgacctgat ccgtttcgag cgtaacatcg tgtgcacctc 7020 catgaagccc atcaacgagg acctggacga gggtatcatg gtggtgtaca agcgcaacat 7080 cgtggctcac accttcaagg tccgcgtgta ccagaaggtg ctgaccttcc gtcgttccta 7140 cgcttacatc cacaccactt acctgctggg ttccaacacc gagtacgtgg cccctcccat 7200 gtgggagatc caccacatca actcccactc ccagtgctac tcctcttact cccgtgtgat 7260 cgctggcacc gtgttcgtgg cttaccaccg tgactcctac gagaacaaga ccatgcagct 7320 gatgcccgac gactactcca acacccactc cacccgttac gtgaccgtga aggaccagtg 7380 gcactcccgt ggttccacct ggctgtaccg tgaaacctgc aacctgaact gcatggtcac 7440 catcaccacc gctcgttcca agtaccctta ccacttcttc gctacctcca ccggcgacgt 7500 ggtggacatc tcccccttct acaacggtac taaccgtaac gcttcctact tcggcgagaa 7560 cgctgacaag ttcttcatct tccccaacta caccatcgtg tccgacttcg gtcgtcccaa 7620 ctccgctctg gaaacccacc gtctggtggc tttcttggag cgtgctgact ccgtgatctc 7680 ctgggacatc caggacgaga agaacgtgac ctgccagctg accttctggg aggcttccga 7740 gcgtaccatc cgttccgagg ctgaggactc ctaccacttc tccagcgcta agatgaccgc 7800 taccttcctg tccaagaaac aagaggtcaa catgtccgac tccgccctgg actgcgtgcg 7860 tgacgaggct atcaacaagc tgcagcagat cttcaacacc tcctacaacc agacctacga 7920 gaagtacgga aacgtgtccg tgttcgagac taccggtggc ctggtggtgt tctggcaggg 7980 tatcaagcag aagtccctgg tcgagctgga acgtctggct aaccgttcct ccctgaacct 8040 gacccacaac cgtaccaagc gttccaccga cggcaacaac gctactcacc tgtccaacat 8100 ggaatccgtg cacaacctgg tgtacgctca gctgcagttc acctacgaca ccctgcgcgg 8160 ttacatcaac cgtgctctgg ctcagatcgc tgaggcttgg tgcgtggacc agcgtcgtac 8220 cctggaagtg ttcaaggaac tgtccaagat caacccctcc gctatcctgt ccgccatcta 8280 caacaagcct atcgctgctc gtttcatggg cgacgtgctg ggcctggctt cctgcgtgac 8340 catcaaccag acttccgtga aggtgctgcg tgacatgaac gtgaaggaat cccccggtcg 8400 ttgctactcc cgtcccgtgg tcatcttcaa cttcgctaac tcctcctacg tgcagtacgg 8460 ccagctgggc gaggacaacg agatcctgct gggcaaccac cgtaccgagg aatgccagct 8520 gccctccctg aagatcttca tcgctggcaa ctccgcttac gaatacgtgg actacctgtt 8580 caagcgcatg atcgacctgt cctccatctc taccgtggac tccatgatcg ctctggacat 8640 cgaccccctg gaaaacaccg acttccgtgt gctggaactg tactcccaga aggaactgcg 8700 ttccatcaac gtgttcgacc tggaagagat catgcgcgag ttcaactcct acaagcagcg 8760 tgttaagtac gtcgaggaca aggtggtgga ccccctgccc ccctacctga agggactgga 8820 cgacctgatg tccggcctgg gagctgccgg caaggctgtg ggtgtcgcta tcggtgctgt 8880 gggtggtgct gtggcttccg tggtcgaggg tgtcgccacc ttcctgaaga accccttcgg 8940 tgctttcacc atcatcctgg tggctatcgc tgtggtcatc atcatctacc tgatctacac 9000 ccgtcagcgt cgtctgtgca tgcagcccct gcagaacctg ttcccctacc tggtgtccgc 9060 tgacggtact accgtgacct ccggcaacac caaggacacc tccctgcagg ctcccccatc 9120 ctacgaggaa tccgtctaca actccggtcg caagggtccc ggtccccctt cctccgacgc 9180 ttctaccgct gctcccccat acaccaacga gcaggcttac cagatgctgc tggctctcgt 9240 gcgtctggac gctgagcagc gtgcacagca gaacggcacc gactccctgg acggccagac 9300 cggaacccag gacaagggcc agaagcccaa cctgctggac cgtctgcgtc accgcaagaa 9360 cggttaccgt cacctgaagg actccgacga ggaagagaac gtctaaggcg cgccaagctt 9420 gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 9480 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 9540 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 9600 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 9660 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9720 cgaaaggaag ctgggaatat taatagatca tggagataat taaaatgata accatctcgc 9780 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 9840 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgc gtcccggcct 9900 gccctcctac ctgatcgtgc tggctgtgtg cctgctgtcc cacctcctgt cctcccgtta 9960 cggtgctgag gctatctccg agcccctgga caaggctttc cacctcctgc tgaacaccta 10020 cggtcgtcct atccgtttcc tgcgcgagaa caccacccag tgcacctaca actcctccct 10080 gcgcaactcc accgtcgtcc gcgagaacgc tatctccttc aacttcttcc agtcctacaa 10140 ccagtactac gtgttccaca tgccccgttg cctgttcgct ggtcccctgg ctgagcagtt 10200 cctgaaccag gtggacctga ccgagactct cgagcgttac cagcagcgtc tgaacactta 10260 cgctctggtg tccaaggacc tggcttccta ccgttccttc agccagcagc tgaaggctca 10320 ggactccctg ggcgagcagc ccaccactgt gcctccccct atcgacctgt ccatccccca 10380 cgtgtggatg cccccccaga ccactcctca cggctggacc gagtcccaca ccacctccgg 10440 actgcaccgt ccccacttca accagacctg catcctgttc gacggtcacg acctgctgtt 10500 ctccaccgtg accccctgcc tgcaccaggg cttctacctc atcgacgagc tgcgttacgt 10560 gaagatcacc ctgaccgagg atttcttcgt ggtcaccgtg tccatcgacg acgacacccc 10620 catgctgctg atcttcggtc acctcccccg tgtgctgttc aaggctccct accagcgtga 10680 caacttcatc ctgcgtcaga ccgagaagca cgagctgctg gtgctggtca agaaggacca 10740 gctgaaccgt cactcttacc tgaaggaccc cgacttcctg gacgctgctc tggacttcaa 10800 ctacctggac ctgtccgctc tgctgaggaa ctccttccac cgttacgctg tggacgtgct 10860 gaagtccggt cgttgccaga tgctggaccg tcgtaccgtc gagatggctt tcgcttacgc 10920 cctggctctg ttcgctgctg ctcgtcaaga agaggctggc gctcaggtgt ccgtgccccg 10980 tgctctggac cgtcaggctg ctctgctgca gatccaagag ttcatgatca cttgcctgtc 11040 ccagaccccc cctcgtacca ccctgctgct gtaccccacc gctgtggacc tggctaagcg 11100 tgctctgtgg acccccaacc agatcaccga catcacctcc ctcgtgcgtc tggtgtacat 11160 cctgtccaag cagaaccagc agcacctgat cccccagtgg gctctgcgtc agatcgctga 11220 cttcgctctg aagctgcaca agacccacct ggcttcattc ctcagcgctt tcgctcgcca 11280 agagctgtac ctgatgggtt ccctggtgca ctccatgctg gtgcacacca ccgagcgtcg 11340 cgagatcttc atcgtggaaa ccggcctgtg ctccctggcc gagctgtccc acttcaccca 11400 gctgctggct cacccccacc acgagtacct gtccgacctg tacaccccct gctcctcttc 11460 cggtcgtcgt gaccactccc tggaacgtct gacccgtctg ttccccgacg ctaccgtgcc 11520 taccaccgtg cctgctgctc tgtccatcct gtctaccatg cagccctcca ccctggaaac 11580 cttccccgac ctgttctgcc tgcctctggg cgagtccttc tccgctctga ccgtgtccga 11640 gcacgtgtcc tacgtggtca ccaaccagta cctgatcaag ggcatctcct accccgtgtc 11700 caccaccgtc gtgggccagt ccctgatcat cacccagacc gactcccaga ccaagtgcga 11760 gctgacccgt aacatgcaca ccactcactc catcaccgct gctctgaaca tctccctcga 11820 gaactgcgct ttctgccagt ccgctctgtt ggagtacgac gacactcagg gtgtcatcaa 11880 catcatgtac atgcacgact ccgacgacgt gctgttcgct ctggacccct acaacgaggt 11940 ggtggtgtcc tccccccgta cccactacct gatgctgctg aagaacggca ccgtgctgga 12000 agtgaccgac gtggtggtgg acgctaccga ccgtctgctg atgatgtccg tgtacgctct 12060 gtccgctatc atcggcatct acctgctgta ccgtatgctg aagacctgct aaggcgccaa 12120 gctttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 12180 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 12240 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 12300 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 12360 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 12420 aaagcccgaa aggaagctga gttggctgct gctgagtagt gcgcgagcaa aatttaagct 12480 acaacaaggc acgcgtccgg aatattaata gatcatggag ataattaaaa tgataaccat 12540 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 12600 aatattccgg attattcata ccgtcccacc atcgggcgcg gatcccggtc cgaagcgcgc 12660 ggaattcaaa ggcctacgtc gacgccacca tggaatcccg tggtcgtcgt tgccccgaga 12720 tgatctccgt gctgggtccc atctccggtc acgtcctgaa ggctgtgttc tcccgtggcg 12780 acacccccgt gctgccccac gaaactcgtc tgctgcagac cggtatccac gtgcgtgtgt 12840 cccagccctc cctgatcctg gtgtcccagt acacccccga ctccacccct tgccaccgcg 12900 gagacaacca gctgcaggtc cagcacacct acttcaccgg ttccgaggtc gagaacgtgt 12960 ccgtgaacgt gcacaacccc accggtcgtt ccatctgccc ctcccaagag cccatgtcca 13020 tctacgtgta cgctctgccc ctgaagatgc tgaacatccc ctccatcaac gtgcaccact 13080 acccctccgc tgctgagcgc aagcaccgtc acctccccgt ggctgacgct gtgatccacg 13140 cttccggcaa gcagatgtgg caggctcgtc tgaccgtgtc cggcctggct tggacccgtc 13200 agcagaacca gtggaaggaa cccgacgtgt actacacctc cgctttcgtg ttccccacca 13260 aggacgtggc cctgcgtcac gtcgtgtgcg ctcacgaact cgtgtgctcc atggaaaaca 13320 cccgtgctac caagatgcaa gtgatcggcg accagtacgt gaaggtgtac ctggaatcct 13380 tctgcgagga cgtgccctcc ggcaagctgt tcatgcacgt gaccctgggt tccgacgtgg 13440 aagaggacct gaccatgacc cgtaaccccc agcccttcat gcgtccccac gagcgtaacg 13500 gtttcaccgt gctgtgcccc aagaacatga tcatcaagcc cggcaagatc tcccacatca 13560 tgctggacgt ggccttcacc tcccacgagc acttcggcct gctgtgccct aagtccatcc 13620 ccggcctgtc catctccggc aacctgctga tgaacggcca gcagatcttc ctggaagtgc 13680 aggctatccg tgaaaccgtc gagctgcgtc agtacgaccc tgtggctgct ctgttcttct 13740 tcgacatcga cctgctgctg cagcgtggtc cccagtactc cgagcacccc accttcacca 13800 gccagtaccg tatccagggc aagctggaat accgtcacac ctgggaccgt cacgacgagg 13860 gtgctgctca gggcgacgac gacgtgtgga cctccggttc cgactccgac gaggaactgg 13920 tcaccaccga gcgcaagacc ccccgtgtga ccggtggtgg tgctatggct ggtgcttcca 13980 cctccgctgg tcgcaagcgc aagtccgctt cctccgctac cgcttgcacc gctggtgtca 14040 tgacccgtgg tcgcctgaag gctgagtcca ccgtggctcc cgaagaggac actgacgagg 14100 actccgacaa cgagatccac aaccccgctg tgttcacctg gcccccctgg caggctggta 14160 tcctggctcg taacctggtg cccatggtgg ctaccgtgca gggccagaac ctgaagtacc 14220 aagagttctt ctgggacgcc aacgacatct accgtatctt cgctgagctg gaaggcgtgt 14280 ggcagcccgc tgctcagccc aagcgtcgtc gtcaccgtca ggacgctctg cctggtccct 14340 gtatcgcttc cacccccaag aagcaccgcg gctaaaagct tgtcgagaag tactagagga 14400 tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc 14460 tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag 14520 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 14580 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct 14640 gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg 14700 gctgctgcca ccgctgagca ataactatca taacccctag gagatccgaa ccagataagt 14760 gaaatctagt tccaaactat tttgtcattt ttaattttcg tattagctta cgacgctaca 14820 cccagttccc atctattttg tcactcttcc ctaaataatc cttaaaaact ccatttccac 14880 ccctcccagt tcccaactat tttgtccgcc caca 14914 <210> 20 <211> 4743 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 20 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatggg 2700 tgctcgtgct tcagtgctgt ccggtggcga gctggacaag tgggagaaga tccgtctgcg 2760 tcccggtggc aagaagcagt acaagctgaa gcacatcgtg tgggcttccc gcgagctgga 2820 acgtttcgct gtgaaccccg gcctgctgga aacctccgag ggttgccgtc agatcctggg 2880 ccagctgcag ccctccctgc agaccggttc cgaggaactg cgttccctgt acaacactat 2940 cgctgtgctg tactgcgtgc accagcgtat cgacgtgaag gacaccaagg aagctctgga 3000 caagatcgag gaagaacaga acaagtccaa gaagaaggcc cagcaggctg ctgctgacac 3060 cggcaacaac tcccaggtgt cccagaacta ccccatcgtg cagaacctgc agggccagat 3120 ggtgcaccag gctatctccc cccgtaccct gaacgcttgg gtcaaggtgg tggaagagaa 3180 ggctttcagc cccgaagtga tccccatgtt ctccgctctg tccgagggtg ctacccccca 3240 ggacctgaac accatgctga acaccgtggg tggtcaccag gctgctatgc agatgctgaa 3300 ggaaaccatc aacgaagagg ctgctgagtg ggaccgtctg caccccgtgc acgctggtcc 3360 tatcgctccc ggacagatgc gcgagccccg tggttccgac atcgctggaa ccacctccac 3420 cctgcaagag cagatcggct ggatgaccca caaccccccc atccccgtgg gcgagatcta 3480 caagcgttgg atcatcctgg gcctgaacaa gatcgtgcgt atgtactccc ccacctccat 3540 cctggacatc cgtcagggtc ccaaggaacc cttccgtgac tacgtggacc gtttctacaa 3600 gaccctgcgt gccgagcagg cttcccaaga ggtcaagaac tggatgaccg agactctgct 3660 ggtgcagaac gctaaccccg actgcaagac catcctgaag gctctgggtc ccggtgctac 3720 cctggaagag atgatgaccg cttgccaggg tgtcggtggt cccggtcaca aggctcgtgt 3780 gctggctgag gctatgtccc aagtgaccaa ccccgctacc atcatgatcc agaagggcaa 3840 cttccgtaac cagcgcaaga ccgtgaagtg cttcaactgc ggcaaggaag gccacatcgc 3900 taagaactgc cgtgctcccc gcaagaaggg ctgctggaag tgcggaaagg aaggacacca 3960 gatgaaggac tgcaccgagc gtcaggctaa cttcctgggc aagatctggc cctcccacaa 4020 gggtcgtccc ggcaacttcc tgcagtcccg tcccgagccc accgctcccc cagaggaatc 4080 cttccgtttc ggcgaggaaa ccaccacccc atcccagaag caagagccca tcgacaagga 4140 actgtacccc ctggcttccc tgcgctccct gttcggttcc gacccatcct cccagtaagg 4200 cgccaagctt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 4260 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 4320 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 4380 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 4440 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 4500 ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactatcat 4560 aacccctagg agatccgaac cagataagtg aaatctagtt ccaaactatt ttgtcatttt 4620 taattttcgt attagcttac gacgctacac ccagttccca tctattttgt cactcttccc 4680 taaataatcc ttaaaaactc catttccacc cctcccagtt cccaactatt ttgtccgccc 4740 aca 4743 <210> 21 <211> 4925 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 21 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatggg 2700 tgctcgtgct tcagtgctgt ccggtggcga gctggacaag tgggagaaga tccgtctgcg 2760 tcccggtggc aagaagcagt acaagctgaa gcacatcgtg tgggcttccc gcgagctgga 2820 acgtttcgct gtgaaccccg gcctgctgga aacctccgag ggttgccgtc agatcctggg 2880 ccagctgcag ccctccctgc agaccggttc cgaggaactg cgttccctgt acaacactat 2940 cgctgtgctg tactgcgtgc accagcgtat cgacgtgaag gacaccaagg aagctctgga 3000 caagatcgag gaagaacaga acaagtccaa gaagaaggcc cagcaggctg ctgctgacac 3060 cggcaacaac tcccaggtgt cccagaacta ccccatcgtg cagaacctgc agggccagat 3120 ggtgcaccag gctatctccc cccgtaccct gaacgcttgg gtcaaggtgg tggaagagaa 3180 ggctttcagc cccgaagtga tccccatgtt ctccgctctg tccgagggtg ctacccccca 3240 ggacctgaac accatgctga acaccgtggg tggtcaccag gctgctatgc agatgctgaa 3300 ggaaaccatc aacgaagagg ctgctgagtg ggaccgtctg caccccgtgc acgctggtcc 3360 tatcgctccc ggacagatgc gcgagccccg tggttccgac atcgctggaa ccacctccac 3420 cctgcaagag cagatcggct ggatgaccca caaccccccc atccccgtgg gcgagatcta 3480 caagcgttgg atcatcctgg gcctgaacaa gatcgtgcgt atgtactccc ccacctccat 3540 cctggacatc cgtcagggtc ccaaggaacc cttccgtgac tacgtggacc gtttctacaa 3600 gaccctgcgt gccgagcagg cttcccaaga ggtcaagaac tggatgaccg agactctgct 3660 ggtgcagaac gctaaccccg actgcaagac catcctgaag gctctgggtc ccggtgctac 3720 cctggaagag atgatgaccg cttgccaggg tgtcggtggt cccggtcaca aggctcgtgt 3780 gctggctgag gctatgtccc aagtgaccaa ccccgctacc atcatgatcc agaagggcaa 3840 cttccgtaac cagcgcaaga ccgtgaagtg cttcaactgc ggcaaggaag gccacatcgc 3900 taagaactgc cgtgctcccc gcaagaaggg ctgctggaag tgcggaaagg aaggacacca 3960 gatgaaggac tgcaccgagc gtcaggctaa cttcctgggc aagatctggc cctcccacaa 4020 gggtcgtccc ggcaacttcc tgcagtcccg tcccgagccc accgctcccc cagaggaatc 4080 cttccgtttc ggcgaggaaa ccaccacccc atcccagaag caagagccca tcgacaagga 4140 actgtacccc ctggcttccc tgcgctccct gttcggttcc gacccatcct cccagggtgg 4200 tggtggctcc ggtggttcct caggtggcgg aggtagtgcc cagctgaaga agaagctcca 4260 ggctctcaag aagaagaacg cccaactgaa atggaagctg caagccttga agaagaagtt 4320 ggcccaattg aagaagaaga accaagccct gaagtggaag ttggctcagt aaaagctttt 4380 aattaaaagc ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag 4440 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 4500 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 4560 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 4620 ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc 4680 tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactatc 4740 ataaccccta ggagatccga accagataag tgaaatctag ttccaaacta ttttgtcatt 4800 tttaattttc gtattagctt acgacgctac acccagttcc catctatttt gtcactcttc 4860 cctaaataat ccttaaaaac tccatttcca cccctcccag ttcccaacta ttttgtccgc 4920 ccaca 4925 <210> 22 <211> 6483 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 22 tgtgggcgga caaaatagtt gggaactggg aggggtggaa atggagtttt taaggattat 60 ttagggaaga gtgacaaaat agatgggaac tgggtgtagc gtcgtaagct aatacgaaaa 120 ttaaaaatga caaaatagtt tggaactaga tttcacttat ctggttcgga tctcctaggg 180 gttatgatag ttattgctca gcggtggcag cagccaactc agcttccttt cgggctttgt 240 tagcagccgg atcttctagg ctcaagcagt gatcagatcc agacatgata agatacattg 300 atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt 360 gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca 420 attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt 480 aaaacctcta caaatgtggt atggctgatt atgatcctct agtacttctc gacaagcttt 540 tagccgcggt gcttcttggg ggtggaagcg atacagggac caggcagagc gtcctgacgg 600 tgacgacgac gcttgggctg agcagcgggc tgccacacgc cttccagctc agcgaagata 660 cggtagatgt cgttggcgtc ccagaagaac tcttggtact tcaggttctg gccctgcacg 720 gtagccacca tgggcaccag gttacgagcc aggataccag cctgccaggg gggccaggtg 780 aacacagcgg ggttgtggat ctcgttgtcg gagtcctcgt cagtgtcctc ttcgggagcc 840 acggtggact cagccttcag gcgaccacgg gtcatgacac cagcggtgca agcggtagcg 900 gaggaagcgg acttgcgctt gcgaccagcg gaggtggaag caccagccat agcaccacca 960 ccggtcacac ggggggtctt gcgctcggtg gtgaccagtt cctcgtcgga gtcggaaccg 1020 gaggtccaca cgtcgtcgtc gccctgagca gcaccctcgt cgtgacggtc ccaggtgtga 1080 cggtattcca gcttgccctg gatacggtac tggctggtga aggtggggtg ctcggagtac 1140 tggggaccac gctgcagcag caggtcgatg tcgaagaaga acagagcagc cacagggtcg 1200 tactgacgca gctcgacggt ttcacggata gcctgcactt ccaggaagat ctgctggccg 1260 ttcatcagca ggttgccgga gatggacagg ccggggatgg acttagggca cagcaggccg 1320 aagtgctcgt gggaggtgaa ggccacgtcc agcatgatgt gggagatctt gccgggcttg 1380 atgatcatgt tcttggggca cagcacggtg aaaccgttac gctcgtgggg acgcatgaag 1440 ggctgggggt tacgggtcat ggtcaggtcc tcttccacgt cggaacccag ggtcacgtgc 1500 atgaacagct tgccggaggg cacgtcctcg cagaaggatt ccaggtacac cttcacgtac 1560 tggtcgccga tcacttgcat cttggtagca cgggtgtttt ccatggagca cacgagttcg 1620 tgagcgcaca cgacgtgacg cagggccacg tccttggtgg ggaacacgaa agcggaggtg 1680 tagtacacgt cgggttcctt ccactggttc tgctgacggg tccaagccag gccggacacg 1740 gtcagacgag cctgccacat ctgcttgccg gaagcgtgga tcacagcgtc agccacgggg 1800 aggtgacggt gcttgcgctc agcagcggag gggtagtggt gcacgttgat ggaggggatg 1860 ttcagcatct tcaggggcag agcgtacacg tagatggaca tgggctcttg ggaggggcag 1920 atggaacgac cggtggggtt gtgcacgttc acggacacgt tctcgacctc ggaaccggtg 1980 aagtaggtgt gctggacctg cagctggttg tctccgcggt ggcaaggggt ggagtcgggg 2040 gtgtactggg acaccaggat cagggagggc tgggacacac gcacgtggat accggtctgc 2100 agcagacgag tttcgtgggg cagcacgggg gtgtcgccac gggagaacac agccttcagg 2160 acgtgaccgg agatgggacc cagcacggag atcatctcgg ggcaacgacg accacgggat 2220 tccatgggcc cagggttgga ctcgacgacg tctcccgcaa gcttaagaag gtcaaaattc 2280 aacagctgct gggaggatgg gtcggaaccg aacagggagc gcagggaagc cagggggtac 2340 agttccttgt cgatgggctc ttgcttctgg gatggggtgg tggtttcctc gccgaaacgg 2400 aaggattcct ctgggggagc ggtgggctcg ggacgggact gcaggaagtt gccgggacga 2460 cccttgtggg agggccagat cttgcccagg aagttagcct gacgctcggt gcagtccttc 2520 atctggtgtc cttcctttcc gcacttccag cagcccttct tgcggggagc acggcagttc 2580 ttagcgatgt ggccttcctt gccgcagttg aagcacttca cggtcttgcg ctggttacgg 2640 aagttgccct tctggatcat gatggtagcg gggttggtca cttgggacat agcctcagcc 2700 agcacacgag ccttgtgacc gggaccaccg acaccctggc aagcggtcat catctcttcc 2760 agggtagcac cgggacccag agccttcagg atggtcttgc agtcggggtt agcgttctgc 2820 accagcagag tctcggtcat ccagttcttg acctcttggg aagcctgctc ggcacgcagg 2880 gtcttgtaga aacggtccac gtagtcacgg aagggttcct tgggaccctg acggatgtcc 2940 aggatggagg tgggggagta catacgcacg atcttgttca ggcccaggat gatccaacgc 3000 ttgtagatct cgcccacggg gatggggggg ttgtgggtca tccagccgat ctgctcttgc 3060 agggtggagg tggttccagc gatgtcggaa ccacggggct cgcgcatctg tccgggagcg 3120 ataggaccag cgtgcacggg gtgcagacgg tcccactcag cagcctcttc gttgatggtt 3180 tccttcagca tctgcatagc agcctggtga ccacccacgg tgttcagcat ggtgttcagg 3240 tcctgggggg tagcaccctc ggacagagcg gagaacatgg ggatcacttc ggggctgaaa 3300 gccttctctt ccaccacctt gacccaagcg ttcagggtac ggggggagat agcctggtgc 3360 accatctggc cctgcaggtt ctgcacgatg gggtagttct gggacacctg ggagttgttg 3420 ccggtgtcag cagcagcctg ctgggccttc ttcttggact tgttctgttc ttcctcgatc 3480 ttgtccagag cttccttggt gtccttcacg tcgatacgct ggtgcacgca gtacagcaca 3540 gcgatagtgt tgtacaggga acgcagttcc tcggaaccgg tctgcaggga gggctgcagc 3600 tggcccagga tctgacggca accctcggag gtttccagca ggccggggtt cacagcgaaa 3660 cgttccagct cgcgggaagc ccacacgatg tgcttcagct tgtactgctt cttgccaccg 3720 ggacgcagac ggatcttctc ccacttgtcc agctcgccac cggacagcac tgaagcacga 3780 gcacccatgg tggcggatcc gcgcccgatg gtgggacggt atgaataatc cggaatattt 3840 ataggttttt ttattacaaa actgttacga aaacagtaaa atacttattt atttgcgaga 3900 tggttatcat tttaattatc tccatgatct attaatattc cggagtaggt cgcgaatcga 3960 tactagtata cggaccttta attcaaccca acacaatata ttatagttaa ataagaatta 4020 ttatcaaatc atttgtatat taattaaaat actatactgt aaattacatt ttatttacaa 4080 tcactcgacg aagacttgat cacccgggat ctcgagccat ggtgctagca gctgatgcat 4140 agcatgcggt accgggagat gggggaggct aactgaaaca cggaaggaga caataccgga 4200 aggaacccgc gctatgacgg caataaaaag acagaataaa acgcacgggt gttgggtcgt 4260 ttgttcataa acgcggggtt cggtcccagg gctggcactc tgtcgatacc ccaccgagac 4320 cccattggga ccaatacgcc cgcgtttctt ccttttcccc accccaaccc ccaagttcgg 4380 gtgaaggccc agggctcgca gccaacgtcg gggcggcaag ccctgccata gccactacgg 4440 gtacgtttaa accagataac ttcgtataat gtatgctata cgaagttatg gtaccgcggc 4500 cgcgtagagg atctgttgat cagcagttca acctgttgat agtacaaaca aagctgtagc 4560 caaccactag aactatagct agagtcctgg gcgaacaaac gatgctcgcc ttccagaaaa 4620 ccgaggatgc gaaccacttc atccggggtc agcaccaccg gcaagcgccg cgacggccga 4680 ggtctaccga tctcctgaag caagggcaga tccgtgcaca gcaccttgcc gtagaagaac 4740 agcaaggccg ccaatgcctg acgatgcgtg gagaccgaaa ccttgcgctc gttcgccagc 4800 caggacagaa atgcctcgac ttcgctgctg cccaaggttg ccgggtgacg cacaccgtgg 4860 aaacggatga aggcacgaac ccagttgaca taagcctgtt cggttcgtaa actgtaatgc 4920 aagtagcgta tgcgctcacg caactggtcc agaaccttga ccgaacgcag cggtggtaac 4980 ggcgcagtgg cggttttcat ggcttgttat gactgttttt ttgtacagtc tatgcctcgg 5040 gcatccaagc agcaagcgcg ttacgccgtg ggtcgatgtt tgatgttatg gagcagcaac 5100 gatgttacgc agcagcaacg atgttacgca gcagggcagt cgccctaaaa caaagttagg 5160 tggctcaagt atgggcatca ttcgcacatg taggctcggc cctgaccaag tcaaatccat 5220 gcgggctgct cttgatcttt tcggtcgtga gttcggagac gtagccacct actcccaaca 5280 tcagccggac tccgattacc tcgggaactt gctccgtagt aagacattca tcgcgcttgc 5340 tgccttcgac caagaagcgg ttgttggcgc tctcgcggct tacgttctgc ccaagtttga 5400 gcagccgcgt agtgagatct atatctatga tctcgcagtc tccggcgagc accggaggca 5460 gggcattgcc accgcgctca tcaatctcct caagcatgag gccaacgcgc ttggtgctta 5520 tgtgatctac gtgcaagcag attacggtga cgatcccgca gtggctctct atacaaagtt 5580 gggcatacgg gaagaagtga tgcactttga tatcgaccca agtaccgcca cctaacaatt 5640 cgttcaagcc gagatcggct tcccggccgc ggagttgttc ggtaaattgt cacaacgccg 5700 cgaatatagt ctttaccatg cccttggcca cgcccctctt taatacgacg ggcaatttgc 5760 acttcagaaa atgaagagtt tgctttagcc ataacaaaag tccagtatgc tttttcacag 5820 cataactgga ctgatttcag tttacaacta ttctgtctag tttaagactt tattgtcata 5880 gtttagatct attttgttca gtttaagact ttattgtccg cccacacccg cttacgcagg 5940 gcatccattt attactcaac cgtaaccgat tttgccaggt tacgcggctg gtctatgcac 6000 tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc 6060 ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc 6120 cttcccaaca gttgcgcagc ctgaatggcg aatggcgcga cgcgccctgt agcggcgcat 6180 taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag 6240 cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc 6300 aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc 6360 ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt 6420 ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa 6480 caa 6483 <210> 23 <211> 11503 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 23 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgcggttcc 4440 tccggtggcg ccggtggctc cggttcctct ggcggttctg gttcctccgc tcaacttgag 4500 aaagaactgc aggctctcga aaaagaaaac gcccaactcg aatgggagct gcaagccttg 4560 gaaaaagaac tggcccaatt ggaaaaagaa aaccaggctt tggaatggga gctggctcag 4620 taaggcgcca agctttgtcg agaagtacta gaggatcata atcagccata ccacatttgt 4680 agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 4740 gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 4800 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 4860 caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctagaagatc 4920 cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct gagcaataac 4980 tatcataacc cctaggggcc tctaaacggg tcttgagggg ttttttgctg aaaggaggaa 5040 ctatatccgg atctgaacag gagggacagc tgatagaaac agaagccact ggagcacctc 5100 aaaaacacca tcatacacta aatcagtaag ttggcagcat cacccgacgc actttgcgcc 5160 gaataaatac ctgtgacgga agatcacttc gcagaataaa taaatcctgg tgtccctgtt 5220 gataccggga agccctgggc caacttttgg cgaaaatgag acgttgatcg gcacgtaaga 5280 ggttccaact ttcaccataa tgaaataaga tcactaccgg gcgtattttt tgagttatcg 5340 agattttcag gagctaagga agctaaaatg gagaaaaaaa tcactggata taccaccgtt 5400 gatatatccc aatggcatcg taaagaacat tttgaggcat ttcagtcagt tgctcaatgt 5460 acctataacc agaccgttca gctggatatt acggcctttt taaagaccgt aaagaaaaat 5520 aagcacaagt tttatccggc ctttattcac attcttgccc gcctgatgaa tgctcatccg 5580 gaattccgta tggcaatgaa agacggtgag ctggtgatat gggatagtgt tcacccttgt 5640 tacaccgttt tccatgagca aactgaaacg ttttcatcgc tctggagtga ataccacgac 5700 gatttccggc agtttctaca catatattcg caagatgtgg cgtgttacgg tgaaaacctg 5760 gcctatttcc ctaaagggtt tattgagaat atgtttttcg tctcagccaa tccctgggtg 5820 agtttcacca gttttgattt aaacgtggcc aatatggaca acttcttcgc ccccgttttc 5880 accatgggca aatattatac gcaaggcgac aaggtgctga tgccgctggc gattcaggtt 5940 catcatgccg tttgtgatgg cttccatgtc ggcagaatgc ttaatgaatt acaacagtac 6000 tgcgatgagt ggcagggcgg ggcgtaattt ttttaaggca gttattggtg cccttaaacg 6060 cctggttgct acgcctgaat aagtgataat aagcggatga atggcagaaa ttcgaaagca 6120 aattcgaccc ggtcgtcggt tcagggcagg gtcgttaaat agccgcttat gtctattgct 6180 ggtttaccgg tttattgact accggaagca gtgtgaccgt gtgcttctca aatgcctgag 6240 gccagtttgc tcaggctctc cccgtggagg taataattga cgatatgatc atttattctg 6300 cctcccagct gacattcatc cggggtcagc accgtttctg cggactggct ttctacgtgt 6360 tccgcttcct ttagcagccc ttgcgccctg agtgcttgcg gcagcgtgaa gctaattctg 6420 tcagccgtta agtgttcctg tgtcactcaa aattgctttg agaggctcta agggcttctc 6480 agtgcgttac atccctggct tgttgtccac aaccgttaaa ccttaaaagc tttaaaagcc 6540 ttatatattc ttttttttct tataaaactt aaaaccttag aggctattta agttgctgat 6600 ttatattaat tttattgttc aaacatgaga gcttagtacg tgaaacatga gagcttagta 6660 cgttagccat gagagcttag tacgttagcc atgagggttt agttcgttaa acatgagagc 6720 ttagtacgtt aaacatgaga gcttagtacg tgaaacatga gagcttagta cgtactatca 6780 acaggttgaa ctgctgatca acagatcctc tacgcggccg cggtaccata acttcgtata 6840 gcatacatta tacgaagtta tctggtttaa acgtacccgt agtggctatg gcagggcttg 6900 ccgccccgac gttggctgcg agccctgggc cttcacccga acttgggggt tggggtgggg 6960 aaaaggaaga aacgcgggcg tattggtccc aatggggtct cggtggggta tcgacagagt 7020 gccagccctg ggaccgaacc ccgcgtttat gaacaaacga cccaacaccc gtgcgtttta 7080 ttctgtcttt ttattgccgt catagcgcgg gttccttccg gtattgtctc cttccgtgtt 7140 tcagttagcc tcccccatct cccggtaccg catgctatgc atcagctgct agcttagcga 7200 gcgtccacag cctggggacc gtaacgggag tgagcgggca ggttcacacg ggtctgcttc 7260 agctcagggg gcaggccagc gtagtacttg tccaggtgac gcagcagggg ggggtccagc 7320 tggtgacgca ggcagaattc cttcacagcg ttgtacaggc cgtagaacag ggtgataccc 7380 tcgggagcag cagcggtgga cacgggcaga cgcacagcac ggttggtacg ggtagcctcg 7440 ttacggatag ccaccaccac gttgaacagg gaggggggca ccagctcgaa acccagcacg 7500 tgttcggtga agatggaacg accgtaggac agacgagtca ggtcgtaacc acggcacagg 7560 tcgtccacgc aagtgtacac agcgggggaa ccgtcgccgc actcggagta accgcgcatc 7620 acggtcatcc aacggggagc ggtgtcggag gacagcaggg tcagcagagc acgcagctgg 7680 tcggggttgt tgtacagcag ggccagggtg tccaggaaag cgtcgtccag cagcacggag 7740 ttagcagcct cgggggtcac gggacggtaa cggatcagct gggacagggg accgtcccta 7800 cgggtcacgt tgaccagggg acgcagccag gactcgtact tgtcgccctg gaacacctct 7860 cccagcaggc aacgacgggt cagctcgggg cactcagcgg gcaccttctc agccacggtg 7920 ggagccacgg acacggtagc ggaggacacg atgggcagca gcaggcagca ccacagcaga 7980 gccacgggac cgggggagaa ggagaaaccg cagtcgggac gacggcacat ggtggctcga 8040 gatcccgggt gatcaagtct tcgtcgagtg attgtaaata aaatgtaatt tacagtatag 8100 tattttaatt aatatacaaa tgatttgata ataattctta tttaactata atatattgtg 8160 ttgggttgaa ttaaaggtcc gtatactagt atcgattcgc gacctactcc ggaatattaa 8220 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 8280 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 8340 ccatcgggcg cggatccgcc accatgtccc ccaagaacct gacccccttc ctgaccgctc 8400 tgtggctgct gctgggccac tcccgtgtgc ctcgtgtgcg tgctgaggaa tgctgcgagt 8460 tcatcaacgt gaaccacccc cccgagcgct gctacgactt caagatgtgc aaccgtttca 8520 ccgtggctct gcgttgcccc gacggcgaag tgtgctactc ccccgaaaag accgctgaga 8580 tccgtggtat cgtgaccacc atgacccact ccctgacccg tcaggtggtg cacaacaagc 8640 tgacctcttg caactacaac cccctgtacc tcgaggctga cggtcgtatc cgttgcggca 8700 aggtcaacga caaggctcag tacctgctgg gtgctgctgg ttccgtgccc taccgttgga 8760 tcaacctcga gtacgacaag atcacccgta tcgtgggcct ggaccagtac ctcgagtccg 8820 tgaagaagca caagcgtctg gacgtgtgcc gtgctaagat gggttacatg ctgcagtaaa 8880 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 8940 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 9000 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 9060 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 9120 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 9180 aaagcccgaa aggaagctga gttggctgct gtggctagct ttgtttaact ttaagaagga 9240 gatacatcta gaccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg 9300 caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata 9360 ttccggatta ttcataccgt cccaccatcg ggcgcggatc cgccaccatg ctgcgtctgc 9420 tgctgcgtca ccacttccac tgcctgctgc tgtgcgctgt gtgggctacc ccctgcctgg 9480 cttccccttg gtccaccctg accgctaacc agaacccctc cccaccctgg tccaagctga 9540 cctactccaa gccccacgac gctgctacct tctactgccc cttcctgtac ccatcccccc 9600 ctcgttcccc actgcagttc tccggtttcc agcgtgtgct gaccggtccc gagtgccgta 9660 acgagactct gtacctgctg tacaaccgcg agggccagac cctggtcgag aggtcctcca 9720 cctgggtcaa gaaggtcatc tggtacttgt ccggtcgtaa ccagaccatc ctgcagcgta 9780 tgccccgtac cgcttccaag ccctccgacg gcaacgtgca gatctccgtc gaggacgcta 9840 agatcttcgg tgctcacatg gtgcccaagc agaccaagct gctgcgtttc gtggtcaacg 9900 acggcacccg ttaccagatg tgcgtgatga agctcgagtc ctgggctcac gtgttccgtg 9960 actactccgt gtccttccaa gtgcgcctga ccttcaccga ggctaacaac cagacctaca 10020 ccttctgcac ccaccccaac ctgatcgtgt aaaagcttgt cgagaagtac tagaggatca 10080 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 10140 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 10200 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 10260 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 10320 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 10380 gctgggtgcc taatgagtga gctaactcac attaattgcc cggaatatta atagatcatg 10440 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 10500 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 10560 gcggatccgc caccatgcgt ctgtgccgtg tgtggctgtc cgtgtgcctg tgcgctgtgg 10620 tgctgggcca gtgccagcgt gaaaccgctg agaagaacga ctactaccgt gtgccccact 10680 actgggacgc ttgctcccgt gctctgcccg accagacccg ttacaagtac gtcgagcagc 10740 tggtggacct gaccctgaac taccactacg acgcttccca cggcctggac aacttcgacg 10800 tgctgaagcg tatcaacgtg accgaggtgt ccctgctgat ctccgacttc cgtcgtcaga 10860 accgtcgtgg tggcaccaac aagcgtacca ccttcaacgc tgctggttcc ctggctcccc 10920 acgctcgttc cctcgagttc tccgtgcgtc tgttcgctaa ctaaaagctt gtcgagaagt 10980 actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc 11040 tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt 11100 ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag 11160 catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg 11220 tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa 11280 gctgagttgg ctgctgccac cgctgagcaa taactatcat aacccctagg agatccgaac 11340 cagataagtg aaatctagtt ccaaactatt ttgtcatttt taattttcgt attagcttac 11400 gacgctacac ccagttccca tctattttgt cactcttccc taaataatcc ttaaaaactc 11460 catttccacc cctcccagtt cccaactatt ttgtccgccc aca 11503 <210> 24 <211> 11503 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 24 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgcggttcc 4440 tccggtggcg ccggtggctc cggttcctct ggcggttctg gttcctccgc tcaacttgag 4500 aaagaactgc aggctctcga aaaagaaaac gcccaactcg aatgggagct gcaagccttg 4560 gaaaaagaac tggcccaatt ggaaaaagaa aaccaggctt tggaatggga gctggctcag 4620 taaggcgcca agctttgtcg agaagtacta gaggatcata atcagccata ccacatttgt 4680 agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 4740 gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 4800 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 4860 caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctagaagatc 4920 cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct gagcaataac 4980 tatcataacc cctaggggcc tctaaacggg tcttgagggg ttttttgctg aaaggaggaa 5040 ctatatccgg atctgaacag gagggacagc tgatagaaac agaagccact ggagcacctc 5100 aaaaacacca tcatacacta aatcagtaag ttggcagcat cacccgacgc actttgcgcc 5160 gaataaatac ctgtgacgga agatcacttc gcagaataaa taaatcctgg tgtccctgtt 5220 gataccggga agccctgggc caacttttgg cgaaaatgag acgttgatcg gcacgtaaga 5280 ggttccaact ttcaccataa tgaaataaga tcactaccgg gcgtattttt tgagttatcg 5340 agattttcag gagctaagga agctaaaatg gagaaaaaaa tcactggata taccaccgtt 5400 gatatatccc aatggcatcg taaagaacat tttgaggcat ttcagtcagt tgctcaatgt 5460 acctataacc agaccgttca gctggatatt acggcctttt taaagaccgt aaagaaaaat 5520 aagcacaagt tttatccggc ctttattcac attcttgccc gcctgatgaa tgctcatccg 5580 gaattccgta tggcaatgaa agacggtgag ctggtgatat gggatagtgt tcacccttgt 5640 tacaccgttt tccatgagca aactgaaacg ttttcatcgc tctggagtga ataccacgac 5700 gatttccggc agtttctaca catatattcg caagatgtgg cgtgttacgg tgaaaacctg 5760 gcctatttcc ctaaagggtt tattgagaat atgtttttcg tctcagccaa tccctgggtg 5820 agtttcacca gttttgattt aaacgtggcc aatatggaca acttcttcgc ccccgttttc 5880 accatgggca aatattatac gcaaggcgac aaggtgctga tgccgctggc gattcaggtt 5940 catcatgccg tttgtgatgg cttccatgtc ggcagaatgc ttaatgaatt acaacagtac 6000 tgcgatgagt ggcagggcgg ggcgtaattt ttttaaggca gttattggtg cccttaaacg 6060 cctggttgct acgcctgaat aagtgataat aagcggatga atggcagaaa ttcgaaagca 6120 aattcgaccc ggtcgtcggt tcagggcagg gtcgttaaat agccgcttat gtctattgct 6180 ggtttaccgg tttattgact accggaagca gtgtgaccgt gtgcttctca aatgcctgag 6240 gccagtttgc tcaggctctc cccgtggagg taataattga cgatatgatc atttattctg 6300 cctcccagct gacattcatc cggggtcagc accgtttctg cggactggct ttctacgtgt 6360 tccgcttcct ttagcagccc ttgcgccctg agtgcttgcg gcagcgtgaa gctaattctg 6420 tcagccgtta agtgttcctg tgtcactcaa aattgctttg agaggctcta agggcttctc 6480 agtgcgttac atccctggct tgttgtccac aaccgttaaa ccttaaaagc tttaaaagcc 6540 ttatatattc ttttttttct tataaaactt aaaaccttag aggctattta agttgctgat 6600 ttatattaat tttattgttc aaacatgaga gcttagtacg tgaaacatga gagcttagta 6660 cgttagccat gagagcttag tacgttagcc atgagggttt agttcgttaa acatgagagc 6720 ttagtacgtt aaacatgaga gcttagtacg tgaaacatga gagcttagta cgtactatca 6780 acaggttgaa ctgctgatca acagatcctc tacgcggccg cggtaccata acttcgtata 6840 gcatacatta tacgaagtta tctggtttaa acgtacccgt agtggctatg gcagggcttg 6900 ccgccccgac gttggctgcg agccctgggc cttcacccga acttgggggt tggggtgggg 6960 aaaaggaaga aacgcgggcg tattggtccc aatggggtct cggtggggta tcgacagagt 7020 gccagccctg ggaccgaacc ccgcgtttat gaacaaacga cccaacaccc gtgcgtttta 7080 ttctgtcttt ttattgccgt catagcgcgg gttccttccg gtattgtctc cttccgtgtt 7140 tcagttagcc tcccccatct cccggtaccg catgctatgc atcagctgct agcttagcga 7200 gcgtccacag cctggggacc gtaacgggag tgagcgggca ggttcacacg ggtctgcttc 7260 agctcagggg gcaggccagc gtagtacttg tccaggtgac gcagcagggg ggggtccagc 7320 tggtgacgca ggcagaattc cttcacagcg ttgtacaggc cgtagaacag ggtgataccc 7380 tcgggagcag cagcggtgga cacgggcaga cgcacagcac ggttggtacg ggtagcctcg 7440 ttacggatag ccaccaccac gttgaacagg gaggggggca ccagctcgaa acccagcacg 7500 tgttcggtga agatggaacg accgtaggac agacgagtca ggtcgtaacc acggcacagg 7560 tcgtccacgc aagtgtacac agcgggggaa ccgtcgccgc actcggagta accgcgcatc 7620 acggtcatcc aacggggagc ggtgtcggag gacagcaggg tcagcagagc acgcagctgg 7680 tcggggttgt tgtacagcag ggccagggtg tccaggaaag cgtcgtccag cagcacggag 7740 ttagcagcct cgggggtcac gggacggtaa cggatcagct gggacagggg accgtcccta 7800 cgggtcacgt tgaccagggg acgcagccag gactcgtact tgtcgccctg gaacacctct 7860 cccagcaggc aacgacgggt cagctcgggg cactcagcgg gcaccttctc agccacggtg 7920 ggagccacgg acacggtagc ggaggacacg atgggcagca gcaggcagca ccacagcaga 7980 gccacgggac cgggggagaa ggagaaaccg cagtcgggac gacggcacat ggtggctcga 8040 gatcccgggt gatcaagtct tcgtcgagtg attgtaaata aaatgtaatt tacagtatag 8100 tattttaatt aatatacaaa tgatttgata ataattctta tttaactata atatattgtg 8160 ttgggttgaa ttaaaggtcc gtatactagt atcgattcgc gacctactcc ggaatattaa 8220 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 8280 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 8340 ccatcgggcg cggatccgcc accatgaact ccaaggacct gacccccttc ctgaccaccc 8400 tgtggctgct gctggaccac tcccgtgtgc ctcgtgtgcg tgctgaggaa tgctgcgaag 8460 tgatcaacgt gaaccacccc cccgagcgct gctacgactt caagatgtgc aacctgttca 8520 ccgtggctct gcgttgcccc gacggcgaag tgtgctactc ccccgaaaag accgctgaga 8580 tccgtggtat cgtgaccacc atgacccact ccctgacccg tcaagtgatc cacaacaagc 8640 tgaccagctg caactacaac cccctgtacc tcgaggctga cggtcgtatc cgttgcggca 8700 aggtgtccga caaggctcag tacctgctgg gtgctgctgg ttccgtgccc taccgttgga 8760 tcaacctcga gtacgacaag atcacccgta tcgtgggcct ggaccagtac ctcgagtccg 8820 tgaagaagca caagcgtctg gacgtgtgcc gtgctaagat gggttacatg ctgcagtaaa 8880 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 8940 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 9000 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 9060 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 9120 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 9180 aaagcccgaa aggaagctga gttggctgct gtggctagct ttgtttaact ttaagaagga 9240 gatacatcta gaccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg 9300 caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata 9360 ttccggatta ttcataccgt cccaccatcg ggcgcggatc cgccaccatg ctgcgtctgc 9420 tgctgcgtca ccacttccac tgcctgctgc tgtgcgctgt gtgggctacc ccctgcctgg 9480 cttccccttg gtccaccctg accgctaacc agaacccctc cccaccctgg tccaagctga 9540 cctactccaa gccccacgac gctgctacct tctactgccc cttcctgtac ccatcccccc 9600 ctcgttcccc actgcagttc tccggtttcc agcgtgtgct gaccggtccc gagtgccgta 9660 acgagactct gtacctgctg tacaaccgcg agggccagac cctggtcgag aggtcctcca 9720 cctgggtcaa gaaggtcatc tggtacttgt ccggtcgtaa ccagaccatc ctgcagcgta 9780 tgccccgtac cgcttccaag ccctccgacg gcaacgtgca gatctccgtc gaggacgcta 9840 agatcttcgg tgctcacatg gtgcccaagc agaccaagct gctgcgtttc gtggtcaacg 9900 acggcacccg ttaccagatg tgcgtgatga agctcgagtc ctgggctcac gtgttccgtg 9960 actactccgt gtccttccaa gtgcgcctga ccttcaccga ggctaacaac cagacctaca 10020 ccttctgcac ccaccccaac ctgatcgtgt aaaagcttgt cgagaagtac tagaggatca 10080 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 10140 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 10200 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 10260 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 10320 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 10380 gctgggtgcc taatgagtga gctaactcac attaattgcc cggaatatta atagatcatg 10440 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 10500 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 10560 gcggatccgc caccatgcgt ctgtgccgtg tgtggctgtc cgtgtgcctg tgcgctgtgg 10620 tgctgggcca gtgccagcgt gaaaccgctg agaagaacga ctactaccgt gtgccccact 10680 actgggacgc ttgctcccgt gctctgcccg accagacccg ttacaagtac gtcgagcagc 10740 tggtggacct gaccctgaac taccactacg acgcttccca cggcctggac aacttcgacg 10800 tgctgaagcg tatcaacgtg accgaggtgt ccctgctgat ctccgacttc cgtcgtcaga 10860 accgtcgtgg tggcaccaac aagcgtacca ccttcaacgc tgctggttcc ctggctcccc 10920 acgctcgttc cctcgagttc tccgtgcgtc tgttcgctaa ctaaaagctt gtcgagaagt 10980 actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc 11040 tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt 11100 ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag 11160 catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg 11220 tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa 11280 gctgagttgg ctgctgccac cgctgagcaa taactatcat aacccctagg agatccgaac 11340 cagataagtg aaatctagtt ccaaactatt ttgtcatttt taattttcgt attagcttac 11400 gacgctacac ccagttccca tctattttgt cactcttccc taaataatcc ttaaaaactc 11460 catttccacc cctcccagtt cccaactatt ttgtccgccc aca 11503 <210> 25 <211> 11619 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 25 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgcggttcc 4440 tccggtggcg ccggtggctc cggttcctct ggcggttctg gttcctccgc tcaacttgag 4500 aaagaactgc aggctctcga aaaagaaaac gcccaactcg aatgggagct gcaagccttg 4560 gaaaaagaac tggcccaatt ggaaaaagaa aaccaggctt tggaatggga gctggctcag 4620 taaggcgcca agctttgtcg agaagtacta gaggatcata atcagccata ccacatttgt 4680 agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 4740 gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 4800 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 4860 caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctagaagatc 4920 cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct gagcaataac 4980 tatcataacc cctaggggcc tctaaacggg tcttgagggg ttttttgctg aaaggaggaa 5040 ctatatccgg atctgaacag gagggacagc tgatagaaac agaagccact ggagcacctc 5100 aaaaacacca tcatacacta aatcagtaag ttggcagcat cacccgacgc actttgcgcc 5160 gaataaatac ctgtgacgga agatcacttc gcagaataaa taaatcctgg tgtccctgtt 5220 gataccggga agccctgggc caacttttgg cgaaaatgag acgttgatcg gcacgtaaga 5280 ggttccaact ttcaccataa tgaaataaga tcactaccgg gcgtattttt tgagttatcg 5340 agattttcag gagctaagga agctaaaatg gagaaaaaaa tcactggata taccaccgtt 5400 gatatatccc aatggcatcg taaagaacat tttgaggcat ttcagtcagt tgctcaatgt 5460 acctataacc agaccgttca gctggatatt acggcctttt taaagaccgt aaagaaaaat 5520 aagcacaagt tttatccggc ctttattcac attcttgccc gcctgatgaa tgctcatccg 5580 gaattccgta tggcaatgaa agacggtgag ctggtgatat gggatagtgt tcacccttgt 5640 tacaccgttt tccatgagca aactgaaacg ttttcatcgc tctggagtga ataccacgac 5700 gatttccggc agtttctaca catatattcg caagatgtgg cgtgttacgg tgaaaacctg 5760 gcctatttcc ctaaagggtt tattgagaat atgtttttcg tctcagccaa tccctgggtg 5820 agtttcacca gttttgattt aaacgtggcc aatatggaca acttcttcgc ccccgttttc 5880 accatgggca aatattatac gcaaggcgac aaggtgctga tgccgctggc gattcaggtt 5940 catcatgccg tttgtgatgg cttccatgtc ggcagaatgc ttaatgaatt acaacagtac 6000 tgcgatgagt ggcagggcgg ggcgtaattt ttttaaggca gttattggtg cccttaaacg 6060 cctggttgct acgcctgaat aagtgataat aagcggatga atggcagaaa ttcgaaagca 6120 aattcgaccc ggtcgtcggt tcagggcagg gtcgttaaat agccgcttat gtctattgct 6180 ggtttaccgg tttattgact accggaagca gtgtgaccgt gtgcttctca aatgcctgag 6240 gccagtttgc tcaggctctc cccgtggagg taataattga cgatatgatc atttattctg 6300 cctcccagct gacattcatc cggggtcagc accgtttctg cggactggct ttctacgtgt 6360 tccgcttcct ttagcagccc ttgcgccctg agtgcttgcg gcagcgtgaa gctaattctg 6420 tcagccgtta agtgttcctg tgtcactcaa aattgctttg agaggctcta agggcttctc 6480 agtgcgttac atccctggct tgttgtccac aaccgttaaa ccttaaaagc tttaaaagcc 6540 ttatatattc ttttttttct tataaaactt aaaaccttag aggctattta agttgctgat 6600 ttatattaat tttattgttc aaacatgaga gcttagtacg tgaaacatga gagcttagta 6660 cgttagccat gagagcttag tacgttagcc atgagggttt agttcgttaa acatgagagc 6720 ttagtacgtt aaacatgaga gcttagtacg tgaaacatga gagcttagta cgtactatca 6780 acaggttgaa ctgctgatca acagatcctc tacgcggccg cggtaccata acttcgtata 6840 gcatacatta tacgaagtta tctggtttaa acgtacccgt agtggctatg gcagggcttg 6900 ccgccccgac gttggctgcg agccctgggc cttcacccga acttgggggt tggggtgggg 6960 aaaaggaaga aacgcgggcg tattggtccc aatggggtct cggtggggta tcgacagagt 7020 gccagccctg ggaccgaacc ccgcgtttat gaacaaacga cccaacaccc gtgcgtttta 7080 ttctgtcttt ttattgccgt catagcgcgg gttccttccg gtattgtctc cttccgtgtt 7140 tcagttagcc tcccccatct cccggtaccg catgctatgc ttagtgatgg tggtggtgat 7200 ggtggtggct gcctcccccc ccagaccccc ctccgccgct tcctttttcg aactgcgggt 7260 ggctccagct acctccgccg ggcccctgga acagaacttc cagggcgcct tagcgagcgt 7320 ccacagcctg gggaccgtaa cgggagtgag cgggcaggtt cacacgggtc tgcttcagct 7380 cagggggcag gccagcgtag tacttgtcca ggtgacgcag cagggggggg tccagctggt 7440 gacgcaggca gaattccttc acagcgttgt acaggccgta gaacagggtg ataccctcgg 7500 gagcagcagc ggtggacacg ggcagacgca cagcacggtt ggtacgggta gcctcgttac 7560 ggatagccac caccacgttg aacagggagg ggggcaccag ctcgaaaccc agcacgtgtt 7620 cggtgaagat ggaacgaccg taggacagac gagtcaggtc gtaaccacgg cacaggtcgt 7680 ccacgcaagt gtacacagcg ggggaaccgt cgccgcactc ggagtaaccg cgcatcacgg 7740 tcatccaacg gggagcggtg tcggaggaca gcagggtcag cagagcacgc agctggtcgg 7800 ggttgttgta cagcagggcc agggtgtcca ggaaagcgtc gtccagcagc acggagttag 7860 cagcctcggg ggtcacggga cggtaacgga tcagctggga caggggaccg tccctacggg 7920 tcacgttgac caggggacgc agccaggact cgtacttgtc gccctggaac acctctccca 7980 gcaggcaacg acgggtcagc tcggggcact cagcgggcac cttctcagcc acggtgggag 8040 ccacggacac ggtagcggag gacacgatgg gcagcagcag gcagcaccac agcagagcca 8100 cgggaccggg ggagaaggag aaaccgcagt cgggacgacg gcacatggtg gctcgagatc 8160 ccgggtgatc aagtcttcgt cgagtgattg taaataaaat gtaatttaca gtatagtatt 8220 ttaattaata tacaaatgat ttgataataa ttcttattta actataatat attgtgttgg 8280 gttgaattaa aggtccgtat actagtatcg attcgcgacc tactccggaa tattaataga 8340 tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt actgttttcg 8400 taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc gtcccaccat 8460 cgggcgcgga tccgccacca tgtcccccaa gaacctgacc cccttcctga ccgctctgtg 8520 gctgctgctg ggccactccc gtgtgcctcg tgtgcgtgct gaggaatgct gcgagttcat 8580 caacgtgaac cacccccccg agcgctgcta cgacttcaag atgtgcaacc gtttcaccgt 8640 ggctctgcgt tgccccgacg gcgaagtgtg ctactccccc gaaaagaccg ctgagatccg 8700 tggtatcgtg accaccatga cccactccct gacccgtcag gtggtgcaca acaagctgac 8760 ctcttgcaac tacaaccccc tgtacctcga ggctgacggt cgtatccgtt gcggcaaggt 8820 caacgacaag gctcagtacc tgctgggtgc tgctggttcc gtgccctacc gttggatcaa 8880 cctcgagtac gacaagatca cccgtatcgt gggcctggac cagtacctcg agtccgtgaa 8940 gaagcacaag cgtctggacg tgtgccgtgc taagatgggt tacatgctgc agtaaaagct 9000 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 9060 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 9120 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 9180 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 9240 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 9300 cccgaaagga agctgagttg gctgctgtgg ctagctttgt ttaactttaa gaaggagata 9360 catctagacc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 9420 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 9480 ggattattca taccgtccca ccatcgggcg cggatccgcc accatgctgc gtctgctgct 9540 gcgtcaccac ttccactgcc tgctgctgtg cgctgtgtgg gctaccccct gcctggcttc 9600 cccttggtcc accctgaccg ctaaccagaa cccctcccca ccctggtcca agctgaccta 9660 ctccaagccc cacgacgctg ctaccttcta ctgccccttc ctgtacccat ccccccctcg 9720 ttccccactg cagttctccg gtttccagcg tgtgctgacc ggtcccgagt gccgtaacga 9780 gactctgtac ctgctgtaca accgcgaggg ccagaccctg gtcgagaggt cctccacctg 9840 ggtcaagaag gtcatctggt acttgtccgg tcgtaaccag accatcctgc agcgtatgcc 9900 ccgtaccgct tccaagccct ccgacggcaa cgtgcagatc tccgtcgagg acgctaagat 9960 cttcggtgct cacatggtgc ccaagcagac caagctgctg cgtttcgtgg tcaacgacgg 10020 cacccgttac cagatgtgcg tgatgaagct cgagtcctgg gctcacgtgt tccgtgacta 10080 ctccgtgtcc ttccaagtgc gcctgacctt caccgaggct aacaaccaga cctacacctt 10140 ctgcacccac cccaacctga tcgtgtaaaa gcttgtcgag aagtactaga ggatcataat 10200 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 10260 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 10320 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 10380 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 10440 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 10500 ggtgcctaat gagtgagcta actcacatta attgcccgga atattaatag atcatggaga 10560 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 10620 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 10680 atccgccacc atgcgtctgt gccgtgtgtg gctgtccgtg tgcctgtgcg ctgtggtgct 10740 gggccagtgc cagcgtgaaa ccgctgagaa gaacgactac taccgtgtgc cccactactg 10800 ggacgcttgc tcccgtgctc tgcccgacca gacccgttac aagtacgtcg agcagctggt 10860 ggacctgacc ctgaactacc actacgacgc ttcccacggc ctggacaact tcgacgtgct 10920 gaagcgtatc aacgtgaccg aggtgtccct gctgatctcc gacttccgtc gtcagaaccg 10980 tcgtggtggc accaacaagc gtaccacctt caacgctgct ggttccctgg ctccccacgc 11040 tcgttccctc gagttctccg tgcgtctgtt cgctaactaa aagcttgtcg agaagtacta 11100 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 11160 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 11220 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 11280 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 11340 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 11400 agttggctgc tgccaccgct gagcaataac tatcataacc cctaggagat ccgaaccaga 11460 taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta gcttacgacg 11520 ctacacccag ttcccatcta ttttgtcact cttccctaaa taatccttaa aaactccatt 11580 tccacccctc ccagttccca actattttgt ccgcccaca 11619 <210> 26 <211> 11619 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 26 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt ttactagtat 2040 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2100 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2160 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2220 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2280 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2340 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2400 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2460 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 2520 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 2580 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 2640 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 2700 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 2760 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 2820 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 2880 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 2940 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3000 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3060 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3120 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3180 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3240 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3300 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3360 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3420 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3480 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 3540 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 3600 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 3660 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 3720 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 3780 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 3840 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 3900 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 3960 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4020 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4080 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4140 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4200 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4260 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4320 ctggaagtga ccgacgtggt ggtggacgct accgaccgtc tgctgatgat gtccgtgtac 4380 gctctgtccg ctatcatcgg catctacctg ctgtaccgta tgctgaagac ctgcggttcc 4440 tccggtggcg ccggtggctc cggttcctct ggcggttctg gttcctccgc tcaacttgag 4500 aaagaactgc aggctctcga aaaagaaaac gcccaactcg aatgggagct gcaagccttg 4560 gaaaaagaac tggcccaatt ggaaaaagaa aaccaggctt tggaatggga gctggctcag 4620 taaggcgcca agctttgtcg agaagtacta gaggatcata atcagccata ccacatttgt 4680 agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 4740 gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 4800 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 4860 caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctagaagatc 4920 cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct gagcaataac 4980 tatcataacc cctaggggcc tctaaacggg tcttgagggg ttttttgctg aaaggaggaa 5040 ctatatccgg atctgaacag gagggacagc tgatagaaac agaagccact ggagcacctc 5100 aaaaacacca tcatacacta aatcagtaag ttggcagcat cacccgacgc actttgcgcc 5160 gaataaatac ctgtgacgga agatcacttc gcagaataaa taaatcctgg tgtccctgtt 5220 gataccggga agccctgggc caacttttgg cgaaaatgag acgttgatcg gcacgtaaga 5280 ggttccaact ttcaccataa tgaaataaga tcactaccgg gcgtattttt tgagttatcg 5340 agattttcag gagctaagga agctaaaatg gagaaaaaaa tcactggata taccaccgtt 5400 gatatatccc aatggcatcg taaagaacat tttgaggcat ttcagtcagt tgctcaatgt 5460 acctataacc agaccgttca gctggatatt acggcctttt taaagaccgt aaagaaaaat 5520 aagcacaagt tttatccggc ctttattcac attcttgccc gcctgatgaa tgctcatccg 5580 gaattccgta tggcaatgaa agacggtgag ctggtgatat gggatagtgt tcacccttgt 5640 tacaccgttt tccatgagca aactgaaacg ttttcatcgc tctggagtga ataccacgac 5700 gatttccggc agtttctaca catatattcg caagatgtgg cgtgttacgg tgaaaacctg 5760 gcctatttcc ctaaagggtt tattgagaat atgtttttcg tctcagccaa tccctgggtg 5820 agtttcacca gttttgattt aaacgtggcc aatatggaca acttcttcgc ccccgttttc 5880 accatgggca aatattatac gcaaggcgac aaggtgctga tgccgctggc gattcaggtt 5940 catcatgccg tttgtgatgg cttccatgtc ggcagaatgc ttaatgaatt acaacagtac 6000 tgcgatgagt ggcagggcgg ggcgtaattt ttttaaggca gttattggtg cccttaaacg 6060 cctggttgct acgcctgaat aagtgataat aagcggatga atggcagaaa ttcgaaagca 6120 aattcgaccc ggtcgtcggt tcagggcagg gtcgttaaat agccgcttat gtctattgct 6180 ggtttaccgg tttattgact accggaagca gtgtgaccgt gtgcttctca aatgcctgag 6240 gccagtttgc tcaggctctc cccgtggagg taataattga cgatatgatc atttattctg 6300 cctcccagct gacattcatc cggggtcagc accgtttctg cggactggct ttctacgtgt 6360 tccgcttcct ttagcagccc ttgcgccctg agtgcttgcg gcagcgtgaa gctaattctg 6420 tcagccgtta agtgttcctg tgtcactcaa aattgctttg agaggctcta agggcttctc 6480 agtgcgttac atccctggct tgttgtccac aaccgttaaa ccttaaaagc tttaaaagcc 6540 ttatatattc ttttttttct tataaaactt aaaaccttag aggctattta agttgctgat 6600 ttatattaat tttattgttc aaacatgaga gcttagtacg tgaaacatga gagcttagta 6660 cgttagccat gagagcttag tacgttagcc atgagggttt agttcgttaa acatgagagc 6720 ttagtacgtt aaacatgaga gcttagtacg tgaaacatga gagcttagta cgtactatca 6780 acaggttgaa ctgctgatca acagatcctc tacgcggccg cggtaccata acttcgtata 6840 gcatacatta tacgaagtta tctggtttaa acgtacccgt agtggctatg gcagggcttg 6900 ccgccccgac gttggctgcg agccctgggc cttcacccga acttgggggt tggggtgggg 6960 aaaaggaaga aacgcgggcg tattggtccc aatggggtct cggtggggta tcgacagagt 7020 gccagccctg ggaccgaacc ccgcgtttat gaacaaacga cccaacaccc gtgcgtttta 7080 ttctgtcttt ttattgccgt catagcgcgg gttccttccg gtattgtctc cttccgtgtt 7140 tcagttagcc tcccccatct cccggtaccg catgctatgc ttagtgatgg tggtggtgat 7200 ggtggtggct gcctcccccc ccagaccccc ctccgccgct tcctttttcg aactgcgggt 7260 ggctccagct acctccgccg ggcccctgga acagaacttc cagggcgcct tagcgagcgt 7320 ccacagcctg gggaccgtaa cgggagtgag cgggcaggtt cacacgggtc tgcttcagct 7380 cagggggcag gccagcgtag tacttgtcca ggtgacgcag cagggggggg tccagctggt 7440 gacgcaggca gaattccttc acagcgttgt acaggccgta gaacagggtg ataccctcgg 7500 gagcagcagc ggtggacacg ggcagacgca cagcacggtt ggtacgggta gcctcgttac 7560 ggatagccac caccacgttg aacagggagg ggggcaccag ctcgaaaccc agcacgtgtt 7620 cggtgaagat ggaacgaccg taggacagac gagtcaggtc gtaaccacgg cacaggtcgt 7680 ccacgcaagt gtacacagcg ggggaaccgt cgccgcactc ggagtaaccg cgcatcacgg 7740 tcatccaacg gggagcggtg tcggaggaca gcagggtcag cagagcacgc agctggtcgg 7800 ggttgttgta cagcagggcc agggtgtcca ggaaagcgtc gtccagcagc acggagttag 7860 cagcctcggg ggtcacggga cggtaacgga tcagctggga caggggaccg tccctacggg 7920 tcacgttgac caggggacgc agccaggact cgtacttgtc gccctggaac acctctccca 7980 gcaggcaacg acgggtcagc tcggggcact cagcgggcac cttctcagcc acggtgggag 8040 ccacggacac ggtagcggag gacacgatgg gcagcagcag gcagcaccac agcagagcca 8100 cgggaccggg ggagaaggag aaaccgcagt cgggacgacg gcacatggtg gctcgagatc 8160 ccgggtgatc aagtcttcgt cgagtgattg taaataaaat gtaatttaca gtatagtatt 8220 ttaattaata tacaaatgat ttgataataa ttcttattta actataatat attgtgttgg 8280 gttgaattaa aggtccgtat actagtatcg attcgcgacc tactccggaa tattaataga 8340 tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt actgttttcg 8400 taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc gtcccaccat 8460 cgggcgcgga tccgccacca tgtcccccaa gaacctgacc cccttcctga ccgctctgtg 8520 gctgctgctg ggccactccc gtgtgcctcg tgtgcgtgct gaggaatgct gcgagttcat 8580 caacgtgaac cacccccccg agcgctgcta cgacttcaag atgtgcaacc gtttcaccgt 8640 ggctctgcgt tgccccgacg gcgaagtgtg ctactccccc gaaaagaccg ctgagatccg 8700 tggtatcgtg accaccatga cccactccct gacccgtcag gtggtgcaca acaagctgac 8760 ctcttgcaac tacaaccccc tgtacctcga ggctgacggt cgtatccgtt gcggcaaggt 8820 caacgacaag gctcagtacc tgctgggtgc tgctggttcc gtgccctacc gttggatcaa 8880 cctcgagtac gacaagatca cccgtatcgt gggcctggac cagtacctcg agtccgtgaa 8940 gaagcacaag cgtctggacg tgtgccgtgc taagatgggt tacatgctgc agtaaaagct 9000 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 9060 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 9120 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 9180 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 9240 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 9300 cccgaaagga agctgagttg gctgctgtgg ctagctttgt ttaactttaa gaaggagata 9360 catctagacc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 9420 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 9480 ggattattca taccgtccca ccatcgggcg cggatccgcc accatgctgc gtctgctgct 9540 gcgtcaccac ttccactgcc tgctgctgtg cgctgtgtgg gctaccccct gcctggcttc 9600 cccttggtcc accctgaccg ctaaccagaa cccctcccca ccctggtcca agctgaccta 9660 ctccaagccc cacgacgctg ctaccttcta ctgccccttc ctgtacccat ccccccctcg 9720 ttccccactg cagttctccg gtttccagcg tgtgctgacc ggtcccgagt gccgtaacga 9780 gactctgtac ctgctgtaca accgcgaggg ccagaccctg gtcgagaggt cctccacctg 9840 ggtcaagaag gtcatctggt acttgtccgg tcgtaaccag accatcctgc agcgtatgcc 9900 ccgtaccgct tccaagccct ccgacggcaa cgtgcagatc tccgtcgagg acgctaagat 9960 cttcggtgct cacatggtgc ccaagcagac caagctgctg cgtttcgtgg tcaacgacgg 10020 cacccgttac cagatgtgcg tgatgaagct cgagtcctgg gctcacgtgt tccgtgacta 10080 ctccgtgtcc ttccaagtgc gcctgacctt caccgaggct aacaaccaga cctacacctt 10140 ctgcacccac cccaacctga tcgtgtaaaa gcttgtcgag aagtactaga ggatcataat 10200 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 10260 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 10320 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 10380 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 10440 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 10500 ggtgcctaat gagtgagcta actcacatta attgcccgga atattaatag atcatggaga 10560 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 10620 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 10680 atccgccacc atgcgtctgt gccgtgtgtg gctgtccgtg tgcctgtgcg ctgtggtgct 10740 gggccagtgc cagcgtgaaa ccgctgagaa gaacgactac taccgtgtgc cccactactg 10800 ggacgcttgc tcccgtgctc tgcccgacca gacccgttac aagtacgtcg agcagctggt 10860 ggacctgacc ctgaactacc actacgacgc ttcccacggc ctggacaact tcgacgtgct 10920 gaagcgtatc aacgtgaccg aggtgtccct gctgatctcc gacttccgtc gtcagaaccg 10980 tcgtggtggc accaacaagc gtaccacctt caacgctgct ggttccctgg ctccccacgc 11040 tcgttccctc gagttctccg tgcgtctgtt cgctaactaa aagcttgtcg agaagtacta 11100 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 11160 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 11220 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 11280 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 11340 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 11400 agttggctgc tgccaccgct gagcaataac tatcataacc cctaggagat ccgaaccaga 11460 taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta gcttacgacg 11520 ctacacccag ttcccatcta ttttgtcact cttccctaaa taatccttaa aaactccatt 11580 tccacccctc ccagttccca actattttgt ccgcccaca 11619 <210> 27 <211> 12844 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 27 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttag cgagcgtcca cagcctgggg accgtaacgg gagtgagcgg 2400 gcaggttcac acgggtctgc ttcagctcag ggggcaggcc agcgtagtac ttgtccaggt 2460 gacgcagcag gggggggtcc agctggtgac gcaggcagaa ttccttcaca gcgttgtaca 2520 ggccgtagaa cagggtgata ccctcgggag cagcagcggt ggacacgggc agacgcacag 2580 cacggttggt acgggtagcc tcgttacgga tagccaccac cacgttgaac agggaggggg 2640 gcaccagctc gaaacccagc acgtgttcgg tgaagatgga acgaccgtag gacagacgag 2700 tcaggtcgta accacggcac aggtcgtcca cgcaagtgta cacagcgggg gaaccgtcgc 2760 cgcactcgga gtaaccgcgc atcacggtca tccaacgggg agcggtgtcg gaggacagca 2820 gggtcagcag agcacgcagc tggtcggggt tgttgtacag cagggccagg gtgtccagga 2880 aagcgtcgtc cagcagcacg gagttagcag cctcgggggt cacgggacgg taacggatca 2940 gctgggacag gggaccgtcc ctacgggtca cgttgaccag gggacgcagc caggactcgt 3000 acttgtcgcc ctggaacacc tctcccagca ggcaacgacg ggtcagctcg gggcactcag 3060 cgggcacctt ctcagccacg gtgggagcca cggacacggt agcggaggac acgatgggca 3120 gcagcaggca gcaccacagc agagccacgg gaccggggga gaaggagaaa ccgcagtcgg 3180 gacgacggca catggtggct cgagatcccg ggtgatcaag tcttcgtcga gtgattgtaa 3240 ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg ataataattc 3300 ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact agtatcgatt 3360 cgcgacctac tccggaatat taatagatca tggagataat taaaatgata accatctcgc 3420 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 3480 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgt cccccaagaa 3540 cctgaccccc ttcctgaccg ctctgtggct gctgctgggc cactcccgtg tgcctcgtgt 3600 gcgtgctgag gaatgctgcg agttcatcaa cgtgaaccac ccccccgagc gctgctacga 3660 cttcaagatg tgcaaccgtt tcaccgtggc tctgcgttgc cccgacggcg aagtgtgcta 3720 ctcccccgaa aagaccgctg agatccgtgg tatcgtgacc accatgaccc actccctgac 3780 ccgtcaggtg gtgcacaaca agctgacctc ttgcaactac aaccccctgt acctcgaggc 3840 tgacggtcgt atccgttgcg gcaaggtcaa cgacaaggct cagtacctgc tgggtgctgc 3900 tggttccgtg ccctaccgtt ggatcaacct cgagtacgac aagatcaccc gtatcgtggg 3960 cctggaccag tacctcgagt ccgtgaagaa gcacaagcgt ctggacgtgt gccgtgctaa 4020 gatgggttac atgctgcagt aaaagcttgt cgagaagtac tagaggatca taatcagcca 4080 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 4140 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 4200 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4260 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 4320 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 4380 gctttgttta actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga 4440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 4500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 4560 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 4620 tgtgtgggct accccctgcc tggcttcccc ttggtccacc ctgaccgcta accagaaccc 4680 ctccccaccc tggtccaagc tgacctactc caagccccac gacgctgcta ccttctactg 4740 ccccttcctg tacccatccc cccctcgttc cccactgcag ttctccggtt tccagcgtgt 4800 gctgaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 4860 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 4920 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 4980 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 5040 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctcga 5100 gtcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 5160 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaaaagct 5220 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 5280 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 5340 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 5400 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 5460 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 5520 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 5580 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 5640 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 5700 ttcataccgt cccaccatcg ggcgcggatc cgccaccatg cgtctgtgcc gtgtgtggct 5760 gtccgtgtgc ctgtgcgctg tggtgctggg ccagtgccag cgtgaaaccg ctgagaagaa 5820 cgactactac cgtgtgcccc actactggga cgcttgctcc cgtgctctgc ccgaccagac 5880 ccgttacaag tacgtcgagc agctggtgga cctgaccctg aactaccact acgacgcttc 5940 ccacggcctg gacaacttcg acgtgctgaa gcgtatcaac gtgaccgagg tgtccctgct 6000 gatctccgac ttccgtcgtc agaaccgtcg tggtggcacc aacaagcgta ccaccttcaa 6060 cgctgctggt tccctggctc cccacgctcg ttccctcgag ttctccgtgc gtctgttcgc 6120 taactaaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 6180 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 6240 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 6300 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 6360 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 6420 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 6480 cataaccccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 6540 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 6600 ggattattca taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattca 6660 aaggcctacc gtcgacgcca ccatggaatc ccgtatctgg tgcctggtcg tgtgcgtgaa 6720 cctgtgcatc gtgtgcctgg gtgctgctgt gtcctcctcc tccacccgtg gcacctccgc 6780 tacccactcc caccactcct cccacaccac ctccgccgct cactcccgtt ccggttccgt 6840 gtcccagcgt gtgacctcct cccagaccgt gtcccacggt gtcaacgaga ctatctacaa 6900 caccaccctg aagtacggcg acgtcgtggg tgtcaacacc accaagtacc cctaccgtgt 6960 gtgctccatg gctcagggca ccgacctgat ccgtttcgag cgtaacatcg tgtgcacctc 7020 catgaagccc atcaacgagg acctggacga gggtatcatg gtggtgtaca agcgcaacat 7080 cgtggctcac accttcaagg tccgcgtgta ccagaaggtg ctgaccttcc gtcgttccta 7140 cgcttacatc cacaccactt acctgctggg ttccaacacc gagtacgtgg cccctcccat 7200 gtgggagatc caccacatca actcccactc ccagtgctac tcctcttact cccgtgtgat 7260 cgctggcacc gtgttcgtgg cttaccaccg tgactcctac gagaacaaga ccatgcagct 7320 gatgcccgac gactactcca acacccactc cacccgttac gtgaccgtga aggaccagtg 7380 gcactcccgt ggttccacct ggctgtaccg tgaaacctgc aacctgaact gcatggtcac 7440 catcaccacc gctcgttcca agtaccctta ccacttcttc gctacctcca ccggcgacgt 7500 ggtggacatc tcccccttct acaacggtac taaccgtaac gcttcctact tcggcgagaa 7560 cgctgacaag ttcttcatct tccccaacta caccatcgtg tccgacttcg gtcgtcccaa 7620 ctccgctctg gaaacccacc gtctggtggc tttcttggag cgtgctgact ccgtgatctc 7680 ctgggacatc caggacgaga agaacgtgac ctgccagctg accttctggg aggcttccga 7740 gcgtaccatc cgttccgagg ctgaggactc ctaccacttc tccagcgcta agatgaccgc 7800 taccttcctg tccaagaaac aagaggtcaa catgtccgac tccgccctgg actgcgtgcg 7860 tgacgaggct atcaacaagc tgcagcagat cttcaacacc tcctacaacc agacctacga 7920 gaagtacgga aacgtgtccg tgttcgagac taccggtggc ctggtggtgt tctggcaggg 7980 tatcaagcag aagtccctgg tcgagctgga acgtctggct aaccgttcct ccctgaacct 8040 gacccacaac cgtaccaagc gttccaccga cggcaacaac gctactcacc tgtccaacat 8100 ggaatccgtg cacaacctgg tgtacgctca gctgcagttc acctacgaca ccctgcgcgg 8160 ttacatcaac cgtgctctgg ctcagatcgc tgaggcttgg tgcgtggacc agcgtcgtac 8220 cctggaagtg ttcaaggaac tgtccaagat caacccctcc gctatcctgt ccgccatcta 8280 caacaagcct atcgctgctc gtttcatggg cgacgtgctg ggcctggctt cctgcgtgac 8340 catcaaccag acttccgtga aggtgctgcg tgacatgaac gtgaaggaat cccccggtcg 8400 ttgctactcc cgtcccgtgg tcatcttcaa cttcgctaac tcctcctacg tgcagtacgg 8460 ccagctgggc gaggacaacg agatcctgct gggcaaccac cgtaccgagg aatgccagct 8520 gccctccctg aagatcttca tcgctggcaa ctccgcttac gaatacgtgg actacctgtt 8580 caagcgcatg atcgacctgt cctccatctc taccgtggac tccatgatcg ctctggacat 8640 cgaccccctg gaaaacaccg acttccgtgt gctggaactg tactcccaga aggaactgcg 8700 ttccatcaac gtgttcgacc tggaagagat catgcgcgag ttcaactcct acaagcagcg 8760 tgttaagtac gtcgaggaca aggtggtgga ccccctgccc ccctacctga agggactgga 8820 cgacctgatg tccggcctgg gagctgccgg caaggctgtg ggtgtcgcta tcggtgctgt 8880 gggtggtgct gtggcttccg tggtcgaggg tgtcgccacc ttcctgaaga accccttcgg 8940 tgctttcacc atcatcctgg tggctatcgc tgtggtcatc atcatctacc tgatctacac 9000 ccgtcagcgt cgtctgtgca tgcagcccct gcagaacctg ttcccctacc tggtgtccgc 9060 tgacggtact accgtgacct ccggcaacac caaggacacc tccctgcagg ctcccccatc 9120 ctacgaggaa tccgtctaca actccggtcg caagggtccc ggtccccctt cctccgacgc 9180 ttctaccgct gctcccccat acaccaacga gcaggcttac cagatgctgc tggctctcgt 9240 gcgtctggac gctgagcagc gtgcacagca gaacggcacc gactccctgg acggccagac 9300 cggaacccag gacaagggcc agaagcccaa cctgctggac cgtctgcgtc accgcaagaa 9360 cggttaccgt cacctgaagg actccgacga ggaagagaac gtctaaggcg cgccaagctt 9420 gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 9480 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 9540 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 9600 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 9660 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9720 cgaaaggaag ctgggaatat taatagatca tggagataat taaaatgata accatctcgc 9780 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 9840 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgc gtcccggcct 9900 gccctcctac ctgatcgtgc tggctgtgtg cctgctgtcc cacctcctgt cctcccgtta 9960 cggtgctgag gctatctccg agcccctgga caaggctttc cacctcctgc tgaacaccta 10020 cggtcgtcct atccgtttcc tgcgcgagaa caccacccag tgcacctaca actcctccct 10080 gcgcaactcc accgtcgtcc gcgagaacgc tatctccttc aacttcttcc agtcctacaa 10140 ccagtactac gtgttccaca tgccccgttg cctgttcgct ggtcccctgg ctgagcagtt 10200 cctgaaccag gtggacctga ccgagactct cgagcgttac cagcagcgtc tgaacactta 10260 cgctctggtg tccaaggacc tggcttccta ccgttccttc agccagcagc tgaaggctca 10320 ggactccctg ggcgagcagc ccaccactgt gcctccccct atcgacctgt ccatccccca 10380 cgtgtggatg cccccccaga ccactcctca cggctggacc gagtcccaca ccacctccgg 10440 actgcaccgt ccccacttca accagacctg catcctgttc gacggtcacg acctgctgtt 10500 ctccaccgtg accccctgcc tgcaccaggg cttctacctc atcgacgagc tgcgttacgt 10560 gaagatcacc ctgaccgagg atttcttcgt ggtcaccgtg tccatcgacg acgacacccc 10620 catgctgctg atcttcggtc acctcccccg tgtgctgttc aaggctccct accagcgtga 10680 caacttcatc ctgcgtcaga ccgagaagca cgagctgctg gtgctggtca agaaggacca 10740 gctgaaccgt cactcttacc tgaaggaccc cgacttcctg gacgctgctc tggacttcaa 10800 ctacctggac ctgtccgctc tgctgaggaa ctccttccac cgttacgctg tggacgtgct 10860 gaagtccggt cgttgccaga tgctggaccg tcgtaccgtc gagatggctt tcgcttacgc 10920 cctggctctg ttcgctgctg ctcgtcaaga agaggctggc gctcaggtgt ccgtgccccg 10980 tgctctggac cgtcaggctg ctctgctgca gatccaagag ttcatgatca cttgcctgtc 11040 ccagaccccc cctcgtacca ccctgctgct gtaccccacc gctgtggacc tggctaagcg 11100 tgctctgtgg acccccaacc agatcaccga catcacctcc ctcgtgcgtc tggtgtacat 11160 cctgtccaag cagaaccagc agcacctgat cccccagtgg gctctgcgtc agatcgctga 11220 cttcgctctg aagctgcaca agacccacct ggcttcattc ctcagcgctt tcgctcgcca 11280 agagctgtac ctgatgggtt ccctggtgca ctccatgctg gtgcacacca ccgagcgtcg 11340 cgagatcttc atcgtggaaa ccggcctgtg ctccctggcc gagctgtccc acttcaccca 11400 gctgctggct cacccccacc acgagtacct gtccgacctg tacaccccct gctcctcttc 11460 cggtcgtcgt gaccactccc tggaacgtct gacccgtctg ttccccgacg ctaccgtgcc 11520 taccaccgtg cctgctgctc tgtccatcct gtctaccatg cagccctcca ccctggaaac 11580 cttccccgac ctgttctgcc tgcctctggg cgagtccttc tccgctctga ccgtgtccga 11640 gcacgtgtcc tacgtggtca ccaaccagta cctgatcaag ggcatctcct accccgtgtc 11700 caccaccgtc gtgggccagt ccctgatcat cacccagacc gactcccaga ccaagtgcga 11760 gctgacccgt aacatgcaca ccactcactc catcaccgct gctctgaaca tctccctcga 11820 gaactgcgct ttctgccagt ccgctctgtt ggagtacgac gacactcagg gtgtcatcaa 11880 catcatgtac atgcacgact ccgacgacgt gctgttcgct ctggacccct acaacgaggt 11940 ggtggtgtcc tccccccgta cccactacct gatgctgctg aagaacggca ccgtgctgga 12000 agtgaccgac gtggtggtgg acgctaccga ccgtctgctg atgatgtccg tgtacgctct 12060 gtccgctatc atcggcatct acctgctgta ccgtatgctg aagacctgcg gttcctccgg 12120 tggcgccggt ggctccggtt cctctggcgg ttctggttcc tccgctcaac ttgagaaaga 12180 actgcaggct ctcgaaaaag aaaacgccca actcgaatgg gagctgcaag ccttggaaaa 12240 agaactggcc caattggaaa aagaaaacca ggctttggaa tgggagctgg ctcagtaagg 12300 cgccaagctt tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg 12360 ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg 12420 caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca 12480 tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac 12540 tcatcaatgt atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct 12600 gctaacaaag cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca 12660 taacccctag gagatccgaa ccagataagt gaaatctagt tccaaactat tttgtcattt 12720 ttaattttcg tattagctta cgacgctaca cccagttccc atctattttg tcactcttcc 12780 ctaaataatc cttaaaaact ccatttccac ccctcccagt tcccaactat tttgtccgcc 12840 caca 12844 <210> 28 <211> 14218 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 28 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttag cgagcgtcca cagcctgggg accgtaacgg gagtgagcgg 2400 gcaggttcac acgggtctgc ttcagctcag ggggcaggcc agcgtagtac ttgtccaggt 2460 gacgcagcag gggggggtcc agctggtgac gcaggcagaa ttccttcaca gcgttgtaca 2520 ggccgtagaa cagggtgata ccctcgggag cagcagcggt ggacacgggc agacgcacag 2580 cacggttggt acgggtagcc tcgttacgga tagccaccac cacgttgaac agggaggggg 2640 gcaccagctc gaaacccagc acgtgttcgg tgaagatgga acgaccgtag gacagacgag 2700 tcaggtcgta accacggcac aggtcgtcca cgcaagtgta cacagcgggg gaaccgtcgc 2760 cgcactcgga gtaaccgcgc atcacggtca tccaacgggg agcggtgtcg gaggacagca 2820 gggtcagcag agcacgcagc tggtcggggt tgttgtacag cagggccagg gtgtccagga 2880 aagcgtcgtc cagcagcacg gagttagcag cctcgggggt cacgggacgg taacggatca 2940 gctgggacag gggaccgtcc ctacgggtca cgttgaccag gggacgcagc caggactcgt 3000 acttgtcgcc ctggaacacc tctcccagca ggcaacgacg ggtcagctcg gggcactcag 3060 cgggcacctt ctcagccacg gtgggagcca cggacacggt agcggaggac acgatgggca 3120 gcagcaggca gcaccacagc agagccacgg gaccggggga gaaggagaaa ccgcagtcgg 3180 gacgacggca catggtggct cgagatcccg ggtgatcaag tcttcgtcga gtgattgtaa 3240 ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg ataataattc 3300 ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact agtatcgatt 3360 cgcgacctac tccggaatat taatagatca tggagataat taaaatgata accatctcgc 3420 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 3480 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgt cccccaagaa 3540 cctgaccccc ttcctgaccg ctctgtggct gctgctgggc cactcccgtg tgcctcgtgt 3600 gcgtgctgag gaatgctgcg agttcatcaa cgtgaaccac ccccccgagc gctgctacga 3660 cttcaagatg tgcaaccgtt tcaccgtggc tctgcgttgc cccgacggcg aagtgtgcta 3720 ctcccccgaa aagaccgctg agatccgtgg tatcgtgacc accatgaccc actccctgac 3780 ccgtcaggtg gtgcacaaca agctgacctc ttgcaactac aaccccctgt acctcgaggc 3840 tgacggtcgt atccgttgcg gcaaggtcaa cgacaaggct cagtacctgc tgggtgctgc 3900 tggttccgtg ccctaccgtt ggatcaacct cgagtacgac aagatcaccc gtatcgtggg 3960 cctggaccag tacctcgagt ccgtgaagaa gcacaagcgt ctggacgtgt gccgtgctaa 4020 gatgggttac atgctgcagt aaaagcttgt cgagaagtac tagaggatca taatcagcca 4080 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 4140 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 4200 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4260 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 4320 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 4380 gctttgttta actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga 4440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 4500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 4560 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 4620 tgtgtgggct accccctgcc tggcttcccc ttggtccacc ctgaccgcta accagaaccc 4680 ctccccaccc tggtccaagc tgacctactc caagccccac gacgctgcta ccttctactg 4740 ccccttcctg tacccatccc cccctcgttc cccactgcag ttctccggtt tccagcgtgt 4800 gctgaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 4860 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 4920 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 4980 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 5040 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctcga 5100 gtcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 5160 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaaaagct 5220 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 5280 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 5340 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 5400 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 5460 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 5520 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 5580 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 5640 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 5700 ttcataccgt cccaccatcg ggcgcggatc cgccaccatg cgtctgtgcc gtgtgtggct 5760 gtccgtgtgc ctgtgcgctg tggtgctggg ccagtgccag cgtgaaaccg ctgagaagaa 5820 cgactactac cgtgtgcccc actactggga cgcttgctcc cgtgctctgc ccgaccagac 5880 ccgttacaag tacgtcgagc agctggtgga cctgaccctg aactaccact acgacgcttc 5940 ccacggcctg gacaacttcg acgtgctgaa gcgtatcaac gtgaccgagg tgtccctgct 6000 gatctccgac ttccgtcgtc agaaccgtcg tggtggcacc aacaagcgta ccaccttcaa 6060 cgctgctggt tccctggctc cccacgctcg ttccctcgag ttctccgtgc gtctgttcgc 6120 taactaaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 6180 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 6240 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 6300 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 6360 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 6420 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 6480 cataaccccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 6540 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 6600 ggattattca taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattca 6660 aaggcctacc gtcgacgcca ccatggaatc ccgtatctgg tgcctggtcg tgtgcgtgaa 6720 cctgtgcatc gtgtgcctgg gtgctgctgt gtcctcctcc tccacccgtg gcacctccgc 6780 tacccactcc caccactcct cccacaccac ctccgccgct cactcccgtt ccggttccgt 6840 gtcccagcgt gtgacctcct cccagaccgt gtcccacggt gtcaacgaga ctatctacaa 6900 caccaccctg aagtacggcg acgtcgtggg tgtcaacacc accaagtacc cctaccgtgt 6960 gtgctccatg gctcagggca ccgacctgat ccgtttcgag cgtaacatcg tgtgcacctc 7020 catgaagccc atcaacgagg acctggacga gggtatcatg gtggtgtaca agcgcaacat 7080 cgtggctcac accttcaagg tccgcgtgta ccagaaggtg ctgaccttcc gtcgttccta 7140 cgcttacatc cacaccactt acctgctggg ttccaacacc gagtacgtgg cccctcccat 7200 gtgggagatc caccacatca actcccactc ccagtgctac tcctcttact cccgtgtgat 7260 cgctggcacc gtgttcgtgg cttaccaccg tgactcctac gagaacaaga ccatgcagct 7320 gatgcccgac gactactcca acacccactc cacccgttac gtgaccgtga aggaccagtg 7380 gcactcccgt ggttccacct ggctgtaccg tgaaacctgc aacctgaact gcatggtcac 7440 catcaccacc gctcgttcca agtaccctta ccacttcttc gctacctcca ccggcgacgt 7500 ggtggacatc tcccccttct acaacggtac taaccgtaac gcttcctact tcggcgagaa 7560 cgctgacaag ttcttcatct tccccaacta caccatcgtg tccgacttcg gtcgtcccaa 7620 ctccgctctg gaaacccacc gtctggtggc tttcttggag cgtgctgact ccgtgatctc 7680 ctgggacatc caggacgaga agaacgtgac ctgccagctg accttctggg aggcttccga 7740 gcgtaccatc cgttccgagg ctgaggactc ctaccacttc tccagcgcta agatgaccgc 7800 taccttcctg tccaagaaac aagaggtcaa catgtccgac tccgccctgg actgcgtgcg 7860 tgacgaggct atcaacaagc tgcagcagat cttcaacacc tcctacaacc agacctacga 7920 gaagtacgga aacgtgtccg tgttcgagac taccggtggc ctggtggtgt tctggcaggg 7980 tatcaagcag aagtccctgg tcgagctgga acgtctggct aaccgttcct ccctgaacct 8040 gacccacaac cgtaccaagc gttccaccga cggcaacaac gctactcacc tgtccaacat 8100 ggaatccgtg cacaacctgg tgtacgctca gctgcagttc acctacgaca ccctgcgcgg 8160 ttacatcaac cgtgctctgg ctcagatcgc tgaggcttgg tgcgtggacc agcgtcgtac 8220 cctggaagtg ttcaaggaac tgtccaagat caacccctcc gctatcctgt ccgccatcta 8280 caacaagcct atcgctgctc gtttcatggg cgacgtgctg ggcctggctt cctgcgtgac 8340 catcaaccag acttccgtga aggtgctgcg tgacatgaac gtgaaggaat cccccggtcg 8400 ttgctactcc cgtcccgtgg tcatcttcaa cttcgctaac tcctcctacg tgcagtacgg 8460 ccagctgggc gaggacaacg agatcctgct gggcaaccac cgtaccgagg aatgccagct 8520 gccctccctg aagatcttca tcgctggcaa ctccgcttac gaatacgtgg actacctgtt 8580 caagcgcatg atcgacctgt cctccatctc taccgtggac tccatgatcg ctctggacat 8640 cgaccccctg gaaaacaccg acttccgtgt gctggaactg tactcccaga aggaactgcg 8700 ttccatcaac gtgttcgacc tggaagagat catgcgcgag ttcaactcct acaagcagcg 8760 tgttaagtac gtcgaggaca aggtggtgga ccccctgccc ccctacctga agggactgga 8820 cgacctgatg tccggcctgg gagctgccgg caaggctgtg ggtgtcgcta tcggtgctgt 8880 gggtggtgct gtggcttccg tggtcgaggg tgtcgccacc ttcctgaaga accccttcgg 8940 tgctttcacc atcatcctgg tggctatcgc tgtggtcatc atcatctacc tgatctacac 9000 ccgtcagcgt cgtctgtgca tgcagcccct gcagaacctg ttcccctacc tggtgtccgc 9060 tgacggtact accgtgacct ccggcaacac caaggacacc tccctgcagg ctcccccatc 9120 ctacgaggaa tccgtctaca actccggtcg caagggtccc ggtccccctt cctccgacgc 9180 ttctaccgct gctcccccat acaccaacga gcaggcttac cagatgctgc tggctctcgt 9240 gcgtctggac gctgagcagc gtgcacagca gaacggcacc gactccctgg acggccagac 9300 cggaacccag gacaagggcc agaagcccaa cctgctggac cgtctgcgtc accgcaagaa 9360 cggttaccgt cacctgaagg actccgacga ggaagagaac gtctaaggcg cgccaagctt 9420 gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 9480 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 9540 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 9600 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 9660 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9720 cgaaaggaag ctgggaatat taatagatca tggagataat taaaatgata accatctcgc 9780 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 9840 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgc gtcccggcct 9900 gccctcctac ctgatcgtgc tggctgtgtg cctgctgtcc cacctcctgt cctcccgtta 9960 cggtgctgag gctatctccg agcccctgga caaggctttc cacctcctgc tgaacaccta 10020 cggtcgtcct atccgtttcc tgcgcgagaa caccacccag tgcacctaca actcctccct 10080 gcgcaactcc accgtcgtcc gcgagaacgc tatctccttc aacttcttcc agtcctacaa 10140 ccagtactac gtgttccaca tgccccgttg cctgttcgct ggtcccctgg ctgagcagtt 10200 cctgaaccag gtggacctga ccgagactct cgagcgttac cagcagcgtc tgaacactta 10260 cgctctggtg tccaaggacc tggcttccta ccgttccttc agccagcagc tgaaggctca 10320 ggactccctg ggcgagcagc ccaccactgt gcctccccct atcgacctgt ccatccccca 10380 cgtgtggatg cccccccaga ccactcctca cggctggacc gagtcccaca ccacctccgg 10440 actgcaccgt ccccacttca accagacctg catcctgttc gacggtcacg acctgctgtt 10500 ctccaccgtg accccctgcc tgcaccaggg cttctacctc atcgacgagc tgcgttacgt 10560 gaagatcacc ctgaccgagg atttcttcgt ggtcaccgtg tccatcgacg acgacacccc 10620 catgctgctg atcttcggtc acctcccccg tgtgctgttc aaggctccct accagcgtga 10680 caacttcatc ctgcgtcaga ccgagaagca cgagctgctg gtgctggtca agaaggacca 10740 gctgaaccgt cactcttacc tgaaggaccc cgacttcctg gacgctgctc tggacttcaa 10800 ctacctggac ctgtccgctc tgctgaggaa ctccttccac cgttacgctg tggacgtgct 10860 gaagtccggt cgttgccaga tgctggaccg tcgtaccgtc gagatggctt tcgcttacgc 10920 cctggctctg ttcgctgctg ctcgtcaaga agaggctggc gctcaggtgt ccgtgccccg 10980 tgctctggac cgtcaggctg ctctgctgca gatccaagag ttcatgatca cttgcctgtc 11040 ccagaccccc cctcgtacca ccctgctgct gtaccccacc gctgtggacc tggctaagcg 11100 tgctctgtgg acccccaacc agatcaccga catcacctcc ctcgtgcgtc tggtgtacat 11160 cctgtccaag cagaaccagc agcacctgat cccccagtgg gctctgcgtc agatcgctga 11220 cttcgctctg aagctgcaca agacccacct ggcttcattc ctcagcgctt tcgctcgcca 11280 agagctgtac ctgatgggtt ccctggtgca ctccatgctg gtgcacacca ccgagcgtcg 11340 cgagatcttc atcgtggaaa ccggcctgtg ctccctggcc gagctgtccc acttcaccca 11400 gctgctggct cacccccacc acgagtacct gtccgacctg tacaccccct gctcctcttc 11460 cggtcgtcgt gaccactccc tggaacgtct gacccgtctg ttccccgacg ctaccgtgcc 11520 taccaccgtg cctgctgctc tgtccatcct gtctaccatg cagccctcca ccctggaaac 11580 cttccccgac ctgttctgcc tgcctctggg cgagtccttc tccgctctga ccgtgtccga 11640 gcacgtgtcc tacgtggtca ccaaccagta cctgatcaag ggcatctcct accccgtgtc 11700 caccaccgtc gtgggccagt ccctgatcat cacccagacc gactcccaga ccaagtgcga 11760 gctgacccgt aacatgcaca ccactcactc catcaccgct gctctgaaca tctccctcga 11820 gaactgcgct ttctgccagt ccgctctgtt ggagtacgac gacactcagg gtgtcatcaa 11880 catcatgtac atgcacgact ccgacgacgt gctgttcgct ctggacccct acaacgaggt 11940 ggtggtgtcc tccccccgta cccactacct gatgctgctg aagaacggca ccgtgctgga 12000 agtgaccgac gtggtggtgg acgctaccga ccgtctgctg atgatgtccg tgtacgctct 12060 gtccgctatc atcggcatct acctgctgta ccgtatgctg aagacctgcc agctgttgaa 12120 ttttgacctt cttaagcttg cgggagacgt cgagtccaac cctgggccca tgggtgctcg 12180 tgcttcagtg ctgtccggtg gcgagctgga caagtgggag aagatccgtc tgcgtcccgg 12240 tggcaagaag cagtacaagc tgaagcacat cgtgtgggct tcccgcgagc tggaacgttt 12300 cgctgtgaac cccggcctgc tggaaacctc cgagggttgc cgtcagatcc tgggccagct 12360 gcagccctcc ctgcagaccg gttccgagga actgcgttcc ctgtacaaca ctatcgctgt 12420 gctgtactgc gtgcaccagc gtatcgacgt gaaggacacc aaggaagctc tggacaagat 12480 cgaggaagaa cagaacaagt ccaagaagaa ggcccagcag gctgctgctg acaccggcaa 12540 caactcccag gtgtcccaga actaccccat cgtgcagaac ctgcagggcc agatggtgca 12600 ccaggctatc tccccccgta ccctgaacgc ttgggtcaag gtggtggaag agaaggcttt 12660 cagccccgaa gtgatcccca tgttctccgc tctgtccgag ggtgctaccc cccaggacct 12720 gaacaccatg ctgaacaccg tgggtggtca ccaggctgct atgcagatgc tgaaggaaac 12780 catcaacgaa gaggctgctg agtgggaccg tctgcacccc gtgcacgctg gtcctatcgc 12840 tcccggacag atgcgcgagc cccgtggttc cgacatcgct ggaaccacct ccaccctgca 12900 agagcagatc ggctggatga cccacaaccc ccccatcccc gtgggcgaga tctacaagcg 12960 ttggatcatc ctgggcctga acaagatcgt gcgtatgtac tcccccacct ccatcctgga 13020 catccgtcag ggtcccaagg aacccttccg tgactacgtg gaccgtttct acaagaccct 13080 gcgtgccgag caggcttccc aagaggtcaa gaactggatg accgagactc tgctggtgca 13140 gaacgctaac cccgactgca agaccatcct gaaggctctg ggtcccggtg ctaccctgga 13200 agagatgatg accgcttgcc agggtgtcgg tggtcccggt cacaaggctc gtgtgctggc 13260 tgaggctatg tcccaagtga ccaaccccgc taccatcatg atccagaagg gcaacttccg 13320 taaccagcgc aagaccgtga agtgcttcaa ctgcggcaag gaaggccaca tcgctaagaa 13380 ctgccgtgct ccccgcaaga agggctgctg gaagtgcgga aaggaaggac accagatgaa 13440 ggactgcacc gagcgtcagg ctaacttcct gggcaagatc tggccctccc acaagggtcg 13500 tcccggcaac ttcctgcagt cccgtcccga gcccaccgct cccccagagg aatccttccg 13560 tttcggcgag gaaaccacca ccccatccca gaagcaagag cccatcgaca aggaactgta 13620 ccccctggct tccctgcgct ccctgttcgg ttccgaccca tcctcccagt aaggcgccca 13680 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 13740 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 13800 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 13860 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 13920 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 13980 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccc 14040 ctaggagatc cgaaccagat aagtgaaatc tagttccaaa ctattttgtc atttttaatt 14100 ttcgtattag cttacgacgc tacacccagt tcccatctat tttgtcactc ttccctaaat 14160 aatccttaaa aactccattt ccacccctcc cagttcccaa ctattttgtc cgcccaca 14218 <210> 29 <211> 14218 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 29 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttag cgagcgtcca cagcctgggg accgtaacgg gagtgagcgg 2400 gcaggttcac acgggtctgc ttcagctcag ggggcaggcc agcgtagtac ttgtccaggt 2460 gacgcagcag gggggggtcc agctggtgac gcaggcagaa ttccttcaca gcgttgtaca 2520 ggccgtagaa cagggtgata ccctcgggag cagcagcggt ggacacgggc agacgcacag 2580 cacggttggt acgggtagcc tcgttacgga tagccaccac cacgttgaac agggaggggg 2640 gcaccagctc gaaacccagc acgtgttcgg tgaagatgga acgaccgtag gacagacgag 2700 tcaggtcgta accacggcac aggtcgtcca cgcaagtgta cacagcgggg gaaccgtcgc 2760 cgcactcgga gtaaccgcgc atcacggtca tccaacgggg agcggtgtcg gaggacagca 2820 gggtcagcag agcacgcagc tggtcggggt tgttgtacag cagggccagg gtgtccagga 2880 aagcgtcgtc cagcagcacg gagttagcag cctcgggggt cacgggacgg taacggatca 2940 gctgggacag gggaccgtcc ctacgggtca cgttgaccag gggacgcagc caggactcgt 3000 acttgtcgcc ctggaacacc tctcccagca ggcaacgacg ggtcagctcg gggcactcag 3060 cgggcacctt ctcagccacg gtgggagcca cggacacggt agcggaggac acgatgggca 3120 gcagcaggca gcaccacagc agagccacgg gaccggggga gaaggagaaa ccgcagtcgg 3180 gacgacggca catggtggct cgagatcccg ggtgatcaag tcttcgtcga gtgattgtaa 3240 ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg ataataattc 3300 ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact agtatcgatt 3360 cgcgacctac tccggaatat taatagatca tggagataat taaaatgata accatctcgc 3420 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 3480 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatga actccaagga 3540 cctgaccccc ttcctgacca ccctgtggct gctgctggac cactcccgtg tgcctcgtgt 3600 gcgtgctgag gaatgctgcg aagtgatcaa cgtgaaccac ccccccgagc gctgctacga 3660 cttcaagatg tgcaacctgt tcaccgtggc tctgcgttgc cccgacggcg aagtgtgcta 3720 ctcccccgaa aagaccgctg agatccgtgg tatcgtgacc accatgaccc actccctgac 3780 ccgtcaagtg atccacaaca agctgaccag ctgcaactac aaccccctgt acctcgaggc 3840 tgacggtcgt atccgttgcg gcaaggtgtc cgacaaggct cagtacctgc tgggtgctgc 3900 tggttccgtg ccctaccgtt ggatcaacct cgagtacgac aagatcaccc gtatcgtggg 3960 cctggaccag tacctcgagt ccgtgaagaa gcacaagcgt ctggacgtgt gccgtgctaa 4020 gatgggttac atgctgcagt aaaagcttgt cgagaagtac tagaggatca taatcagcca 4080 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 4140 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 4200 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4260 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 4320 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 4380 gctttgttta actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga 4440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 4500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 4560 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 4620 tgtgtgggct accccctgcc tggcttcccc ttggtccacc ctgaccgcta accagaaccc 4680 ctccccaccc tggtccaagc tgacctactc caagccccac gacgctgcta ccttctactg 4740 ccccttcctg tacccatccc cccctcgttc cccactgcag ttctccggtt tccagcgtgt 4800 gctgaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 4860 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 4920 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 4980 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 5040 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctcga 5100 gtcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 5160 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaaaagct 5220 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 5280 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 5340 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 5400 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 5460 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 5520 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 5580 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 5640 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 5700 ttcataccgt cccaccatcg ggcgcggatc cgccaccatg cgtctgtgcc gtgtgtggct 5760 gtccgtgtgc ctgtgcgctg tggtgctggg ccagtgccag cgtgaaaccg ctgagaagaa 5820 cgactactac cgtgtgcccc actactggga cgcttgctcc cgtgctctgc ccgaccagac 5880 ccgttacaag tacgtcgagc agctggtgga cctgaccctg aactaccact acgacgcttc 5940 ccacggcctg gacaacttcg acgtgctgaa gcgtatcaac gtgaccgagg tgtccctgct 6000 gatctccgac ttccgtcgtc agaaccgtcg tggtggcacc aacaagcgta ccaccttcaa 6060 cgctgctggt tccctggctc cccacgctcg ttccctcgag ttctccgtgc gtctgttcgc 6120 taactaaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 6180 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 6240 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 6300 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 6360 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 6420 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 6480 cataaccccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 6540 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 6600 ggattattca taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattca 6660 aaggcctacc gtcgacgcca ccatggaatc ccgtatctgg tgcctggtcg tgtgcgtgaa 6720 cctgtgcatc gtgtgcctgg gtgctgctgt gtcctcctcc tccacccgtg gcacctccgc 6780 tacccactcc caccactcct cccacaccac ctccgccgct cactcccgtt ccggttccgt 6840 gtcccagcgt gtgacctcct cccagaccgt gtcccacggt gtcaacgaga ctatctacaa 6900 caccaccctg aagtacggcg acgtcgtggg tgtcaacacc accaagtacc cctaccgtgt 6960 gtgctccatg gctcagggca ccgacctgat ccgtttcgag cgtaacatcg tgtgcacctc 7020 catgaagccc atcaacgagg acctggacga gggtatcatg gtggtgtaca agcgcaacat 7080 cgtggctcac accttcaagg tccgcgtgta ccagaaggtg ctgaccttcc gtcgttccta 7140 cgcttacatc cacaccactt acctgctggg ttccaacacc gagtacgtgg cccctcccat 7200 gtgggagatc caccacatca actcccactc ccagtgctac tcctcttact cccgtgtgat 7260 cgctggcacc gtgttcgtgg cttaccaccg tgactcctac gagaacaaga ccatgcagct 7320 gatgcccgac gactactcca acacccactc cacccgttac gtgaccgtga aggaccagtg 7380 gcactcccgt ggttccacct ggctgtaccg tgaaacctgc aacctgaact gcatggtcac 7440 catcaccacc gctcgttcca agtaccctta ccacttcttc gctacctcca ccggcgacgt 7500 ggtggacatc tcccccttct acaacggtac taaccgtaac gcttcctact tcggcgagaa 7560 cgctgacaag ttcttcatct tccccaacta caccatcgtg tccgacttcg gtcgtcccaa 7620 ctccgctctg gaaacccacc gtctggtggc tttcttggag cgtgctgact ccgtgatctc 7680 ctgggacatc caggacgaga agaacgtgac ctgccagctg accttctggg aggcttccga 7740 gcgtaccatc cgttccgagg ctgaggactc ctaccacttc tccagcgcta agatgaccgc 7800 taccttcctg tccaagaaac aagaggtcaa catgtccgac tccgccctgg actgcgtgcg 7860 tgacgaggct atcaacaagc tgcagcagat cttcaacacc tcctacaacc agacctacga 7920 gaagtacgga aacgtgtccg tgttcgagac taccggtggc ctggtggtgt tctggcaggg 7980 tatcaagcag aagtccctgg tcgagctgga acgtctggct aaccgttcct ccctgaacct 8040 gacccacaac cgtaccaagc gttccaccga cggcaacaac gctactcacc tgtccaacat 8100 ggaatccgtg cacaacctgg tgtacgctca gctgcagttc acctacgaca ccctgcgcgg 8160 ttacatcaac cgtgctctgg ctcagatcgc tgaggcttgg tgcgtggacc agcgtcgtac 8220 cctggaagtg ttcaaggaac tgtccaagat caacccctcc gctatcctgt ccgccatcta 8280 caacaagcct atcgctgctc gtttcatggg cgacgtgctg ggcctggctt cctgcgtgac 8340 catcaaccag acttccgtga aggtgctgcg tgacatgaac gtgaaggaat cccccggtcg 8400 ttgctactcc cgtcccgtgg tcatcttcaa cttcgctaac tcctcctacg tgcagtacgg 8460 ccagctgggc gaggacaacg agatcctgct gggcaaccac cgtaccgagg aatgccagct 8520 gccctccctg aagatcttca tcgctggcaa ctccgcttac gaatacgtgg actacctgtt 8580 caagcgcatg atcgacctgt cctccatctc taccgtggac tccatgatcg ctctggacat 8640 cgaccccctg gaaaacaccg acttccgtgt gctggaactg tactcccaga aggaactgcg 8700 ttccatcaac gtgttcgacc tggaagagat catgcgcgag ttcaactcct acaagcagcg 8760 tgttaagtac gtcgaggaca aggtggtgga ccccctgccc ccctacctga agggactgga 8820 cgacctgatg tccggcctgg gagctgccgg caaggctgtg ggtgtcgcta tcggtgctgt 8880 gggtggtgct gtggcttccg tggtcgaggg tgtcgccacc ttcctgaaga accccttcgg 8940 tgctttcacc atcatcctgg tggctatcgc tgtggtcatc atcatctacc tgatctacac 9000 ccgtcagcgt cgtctgtgca tgcagcccct gcagaacctg ttcccctacc tggtgtccgc 9060 tgacggtact accgtgacct ccggcaacac caaggacacc tccctgcagg ctcccccatc 9120 ctacgaggaa tccgtctaca actccggtcg caagggtccc ggtccccctt cctccgacgc 9180 ttctaccgct gctcccccat acaccaacga gcaggcttac cagatgctgc tggctctcgt 9240 gcgtctggac gctgagcagc gtgcacagca gaacggcacc gactccctgg acggccagac 9300 cggaacccag gacaagggcc agaagcccaa cctgctggac cgtctgcgtc accgcaagaa 9360 cggttaccgt cacctgaagg actccgacga ggaagagaac gtctaaggcg cgccaagctt 9420 gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 9480 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 9540 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 9600 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 9660 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9720 cgaaaggaag ctgggaatat taatagatca tggagataat taaaatgata accatctcgc 9780 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 9840 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgc gtcccggcct 9900 gccctcctac ctgatcgtgc tggctgtgtg cctgctgtcc cacctcctgt cctcccgtta 9960 cggtgctgag gctatctccg agcccctgga caaggctttc cacctcctgc tgaacaccta 10020 cggtcgtcct atccgtttcc tgcgcgagaa caccacccag tgcacctaca actcctccct 10080 gcgcaactcc accgtcgtcc gcgagaacgc tatctccttc aacttcttcc agtcctacaa 10140 ccagtactac gtgttccaca tgccccgttg cctgttcgct ggtcccctgg ctgagcagtt 10200 cctgaaccag gtggacctga ccgagactct cgagcgttac cagcagcgtc tgaacactta 10260 cgctctggtg tccaaggacc tggcttccta ccgttccttc agccagcagc tgaaggctca 10320 ggactccctg ggcgagcagc ccaccactgt gcctccccct atcgacctgt ccatccccca 10380 cgtgtggatg cccccccaga ccactcctca cggctggacc gagtcccaca ccacctccgg 10440 actgcaccgt ccccacttca accagacctg catcctgttc gacggtcacg acctgctgtt 10500 ctccaccgtg accccctgcc tgcaccaggg cttctacctc atcgacgagc tgcgttacgt 10560 gaagatcacc ctgaccgagg atttcttcgt ggtcaccgtg tccatcgacg acgacacccc 10620 catgctgctg atcttcggtc acctcccccg tgtgctgttc aaggctccct accagcgtga 10680 caacttcatc ctgcgtcaga ccgagaagca cgagctgctg gtgctggtca agaaggacca 10740 gctgaaccgt cactcttacc tgaaggaccc cgacttcctg gacgctgctc tggacttcaa 10800 ctacctggac ctgtccgctc tgctgaggaa ctccttccac cgttacgctg tggacgtgct 10860 gaagtccggt cgttgccaga tgctggaccg tcgtaccgtc gagatggctt tcgcttacgc 10920 cctggctctg ttcgctgctg ctcgtcaaga agaggctggc gctcaggtgt ccgtgccccg 10980 tgctctggac cgtcaggctg ctctgctgca gatccaagag ttcatgatca cttgcctgtc 11040 ccagaccccc cctcgtacca ccctgctgct gtaccccacc gctgtggacc tggctaagcg 11100 tgctctgtgg acccccaacc agatcaccga catcacctcc ctcgtgcgtc tggtgtacat 11160 cctgtccaag cagaaccagc agcacctgat cccccagtgg gctctgcgtc agatcgctga 11220 cttcgctctg aagctgcaca agacccacct ggcttcattc ctcagcgctt tcgctcgcca 11280 agagctgtac ctgatgggtt ccctggtgca ctccatgctg gtgcacacca ccgagcgtcg 11340 cgagatcttc atcgtggaaa ccggcctgtg ctccctggcc gagctgtccc acttcaccca 11400 gctgctggct cacccccacc acgagtacct gtccgacctg tacaccccct gctcctcttc 11460 cggtcgtcgt gaccactccc tggaacgtct gacccgtctg ttccccgacg ctaccgtgcc 11520 taccaccgtg cctgctgctc tgtccatcct gtctaccatg cagccctcca ccctggaaac 11580 cttccccgac ctgttctgcc tgcctctggg cgagtccttc tccgctctga ccgtgtccga 11640 gcacgtgtcc tacgtggtca ccaaccagta cctgatcaag ggcatctcct accccgtgtc 11700 caccaccgtc gtgggccagt ccctgatcat cacccagacc gactcccaga ccaagtgcga 11760 gctgacccgt aacatgcaca ccactcactc catcaccgct gctctgaaca tctccctcga 11820 gaactgcgct ttctgccagt ccgctctgtt ggagtacgac gacactcagg gtgtcatcaa 11880 catcatgtac atgcacgact ccgacgacgt gctgttcgct ctggacccct acaacgaggt 11940 ggtggtgtcc tccccccgta cccactacct gatgctgctg aagaacggca ccgtgctgga 12000 agtgaccgac gtggtggtgg acgctaccga ccgtctgctg atgatgtccg tgtacgctct 12060 gtccgctatc atcggcatct acctgctgta ccgtatgctg aagacctgcc agctgttgaa 12120 ttttgacctt cttaagcttg cgggagacgt cgagtccaac cctgggccca tgggtgctcg 12180 tgcttcagtg ctgtccggtg gcgagctgga caagtgggag aagatccgtc tgcgtcccgg 12240 tggcaagaag cagtacaagc tgaagcacat cgtgtgggct tcccgcgagc tggaacgttt 12300 cgctgtgaac cccggcctgc tggaaacctc cgagggttgc cgtcagatcc tgggccagct 12360 gcagccctcc ctgcagaccg gttccgagga actgcgttcc ctgtacaaca ctatcgctgt 12420 gctgtactgc gtgcaccagc gtatcgacgt gaaggacacc aaggaagctc tggacaagat 12480 cgaggaagaa cagaacaagt ccaagaagaa ggcccagcag gctgctgctg acaccggcaa 12540 caactcccag gtgtcccaga actaccccat cgtgcagaac ctgcagggcc agatggtgca 12600 ccaggctatc tccccccgta ccctgaacgc ttgggtcaag gtggtggaag agaaggcttt 12660 cagccccgaa gtgatcccca tgttctccgc tctgtccgag ggtgctaccc cccaggacct 12720 gaacaccatg ctgaacaccg tgggtggtca ccaggctgct atgcagatgc tgaaggaaac 12780 catcaacgaa gaggctgctg agtgggaccg tctgcacccc gtgcacgctg gtcctatcgc 12840 tcccggacag atgcgcgagc cccgtggttc cgacatcgct ggaaccacct ccaccctgca 12900 agagcagatc ggctggatga cccacaaccc ccccatcccc gtgggcgaga tctacaagcg 12960 ttggatcatc ctgggcctga acaagatcgt gcgtatgtac tcccccacct ccatcctgga 13020 catccgtcag ggtcccaagg aacccttccg tgactacgtg gaccgtttct acaagaccct 13080 gcgtgccgag caggcttccc aagaggtcaa gaactggatg accgagactc tgctggtgca 13140 gaacgctaac cccgactgca agaccatcct gaaggctctg ggtcccggtg ctaccctgga 13200 agagatgatg accgcttgcc agggtgtcgg tggtcccggt cacaaggctc gtgtgctggc 13260 tgaggctatg tcccaagtga ccaaccccgc taccatcatg atccagaagg gcaacttccg 13320 taaccagcgc aagaccgtga agtgcttcaa ctgcggcaag gaaggccaca tcgctaagaa 13380 ctgccgtgct ccccgcaaga agggctgctg gaagtgcgga aaggaaggac accagatgaa 13440 ggactgcacc gagcgtcagg ctaacttcct gggcaagatc tggccctccc acaagggtcg 13500 tcccggcaac ttcctgcagt cccgtcccga gcccaccgct cccccagagg aatccttccg 13560 tttcggcgag gaaaccacca ccccatccca gaagcaagag cccatcgaca aggaactgta 13620 ccccctggct tccctgcgct ccctgttcgg ttccgaccca tcctcccagt aaggcgccca 13680 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 13740 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 13800 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 13860 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 13920 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 13980 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccc 14040 ctaggagatc cgaaccagat aagtgaaatc tagttccaaa ctattttgtc atttttaatt 14100 ttcgtattag cttacgacgc tacacccagt tcccatctat tttgtcactc ttccctaaat 14160 aatccttaaa aactccattt ccacccctcc cagttcccaa ctattttgtc cgcccaca 14218 <210> 30 <211> 14239 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 30 tgtgggcgga caaaatagtt gggaactggg aggggtggaa atggagtttt taaggattat 60 ttagggaaga gtgacaaaat agatgggaac tgggtgtagc gtcgtaagct aatacgaaaa 120 ttaaaaatga caaaatagtt tggaactaga tttcacttat ctggttcgga tctcctaggg 180 gttatgatag ttattgctca gcggtggcag cagccaactc agcttccttt cgggctttgt 240 tagcagccgg atcttctagg ctcaagcagt gatcagatcc agacatgata agatacattg 300 atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt 360 gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca 420 attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt 480 aaaacctcta caaatgtggt atggctgatt atgatcctct agtacttctc gacaagcttg 540 ggcgccttac tgggaggatg ggtcggaacc gaacagggag cgcagggaag ccagggggta 600 cagttccttg tcgatgggct cttgcttctg ggatggggtg gtggtttcct cgccgaaacg 660 gaaggattcc tctgggggag cggtgggctc gggacgggac tgcaggaagt tgccgggacg 720 acccttgtgg gagggccaga tcttgcccag gaagttagcc tgacgctcgg tgcagtcctt 780 catctggtgt ccttcctttc cgcacttcca gcagcccttc ttgcggggag cacggcagtt 840 cttagcgatg tggccttcct tgccgcagtt gaagcacttc acggtcttgc gctggttacg 900 gaagttgccc ttctggatca tgatggtagc ggggttggtc acttgggaca tagcctcagc 960 cagcacacga gccttgtgac cgggaccacc gacaccctgg caagcggtca tcatctcttc 1020 cagggtagca ccgggaccca gagccttcag gatggtcttg cagtcggggt tagcgttctg 1080 caccagcaga gtctcggtca tccagttctt gacctcttgg gaagcctgct cggcacgcag 1140 ggtcttgtag aaacggtcca cgtagtcacg gaagggttcc ttgggaccct gacggatgtc 1200 caggatggag gtgggggagt acatacgcac gatcttgttc aggcccagga tgatccaacg 1260 cttgtagatc tcgcccacgg ggatgggggg gttgtgggtc atccagccga tctgctcttg 1320 cagggtggag gtggttccag cgatgtcgga accacggggc tcgcgcatct gtccgggagc 1380 gataggacca gcgtgcacgg ggtgcagacg gtcccactca gcagcctctt cgttgatggt 1440 ttccttcagc atctgcatag cagcctggtg accacccacg gtgttcagca tggtgttcag 1500 gtcctggggg gtagcaccct cggacagagc ggagaacatg gggatcactt cggggctgaa 1560 agccttctct tccaccacct tgacccaagc gttcagggta cggggggaga tagcctggtg 1620 caccatctgg ccctgcaggt tctgcacgat ggggtagttc tgggacacct gggagttgtt 1680 gccggtgtca gcagcagcct gctgggcctt cttcttggac ttgttctgtt cttcctcgat 1740 cttgtccaga gcttccttgg tgtccttcac gtcgatacgc tggtgcacgc agtacagcac 1800 agcgatagtg ttgtacaggg aacgcagttc ctcggaaccg gtctgcaggg agggctgcag 1860 ctggcccagg atctgacggc aaccctcgga ggtttccagc aggccggggt tcacagcgaa 1920 acgttccagc tcgcgggaag cccacacgat gtgcttcagc ttgtactgct tcttgccacc 1980 gggacgcaga cggatcttct cccacttgtc cagctcgcca ccggacagca ctgaagcacg 2040 agcacccatg ggcccagggt tggactcgac gtctcccgca agcttaagaa ggtcaaaatt 2100 caacagctgg caggtcttca gcatacggta cagcaggtag atgccgatga tagcggacag 2160 agcgtacacg gacatcatca gcagacggtc ggtagcgtcc accaccacgt cggtcacttc 2220 cagcacggtg ccgttcttca gcagcatcag gtagtgggta cggggggagg acaccaccac 2280 ctcgttgtag gggtccagag cgaacagcac gtcgtcggag tcgtgcatgt acatgatgtt 2340 gatgacaccc tgagtgtcgt cgtactccaa cagagcggac tggcagaaag cgcagttctc 2400 gagggagatg ttcagagcag cggtgatgga gtgagtggtg tgcatgttac gggtcagctc 2460 gcacttggtc tgggagtcgg tctgggtgat gatcagggac tggcccacga cggtggtgga 2520 cacggggtag gagatgccct tgatcaggta ctggttggtg accacgtagg acacgtgctc 2580 ggacacggtc agagcggaga aggactcgcc cagaggcagg cagaacaggt cggggaaggt 2640 ttccagggtg gagggctgca tggtagacag gatggacaga gcagcaggca cggtggtagg 2700 cacggtagcg tcggggaaca gacgggtcag acgttccagg gagtggtcac gacgaccgga 2760 agaggagcag ggggtgtaca ggtcggacag gtactcgtgg tgggggtgag ccagcagctg 2820 ggtgaagtgg gacagctcgg ccagggagca caggccggtt tccacgatga agatctcgcg 2880 acgctcggtg gtgtgcacca gcatggagtg caccagggaa cccatcaggt acagctcttg 2940 gcgagcgaaa gcgctgagga atgaagccag gtgggtcttg tgcagcttca gagcgaagtc 3000 agcgatctga cgcagagccc actgggggat caggtgctgc tggttctgct tggacaggat 3060 gtacaccaga cgcacgaggg aggtgatgtc ggtgatctgg ttgggggtcc acagagcacg 3120 cttagccagg tccacagcgg tggggtacag cagcagggtg gtacgagggg gggtctggga 3180 caggcaagtg atcatgaact cttggatctg cagcagagca gcctgacggt ccagagcacg 3240 gggcacggac acctgagcgc cagcctcttc ttgacgagca gcagcgaaca gagccagggc 3300 gtaagcgaaa gccatctcga cggtacgacg gtccagcatc tggcaacgac cggacttcag 3360 cacgtccaca gcgtaacggt ggaaggagtt cctcagcaga gcggacaggt ccaggtagtt 3420 gaagtccaga gcagcgtcca ggaagtcggg gtccttcagg taagagtgac ggttcagctg 3480 gtccttcttg accagcacca gcagctcgtg cttctcggtc tgacgcagga tgaagttgtc 3540 acgctggtag ggagccttga acagcacacg ggggaggtga ccgaagatca gcagcatggg 3600 ggtgtcgtcg tcgatggaca cggtgaccac gaagaaatcc tcggtcaggg tgatcttcac 3660 gtaacgcagc tcgtcgatga ggtagaagcc ctggtgcagg cagggggtca cggtggagaa 3720 cagcaggtcg tgaccgtcga acaggatgca ggtctggttg aagtggggac ggtgcagtcc 3780 ggaggtggtg tgggactcgg tccagccgtg aggagtggtc tgggggggca tccacacgtg 3840 ggggatggac aggtcgatag ggggaggcac agtggtgggc tgctcgccca gggagtcctg 3900 agccttcagc tgctggctga aggaacggta ggaagccagg tccttggaca ccagagcgta 3960 agtgttcaga cgctgctggt aacgctcgag agtctcggtc aggtccacct ggttcaggaa 4020 ctgctcagcc aggggaccag cgaacaggca acggggcatg tggaacacgt agtactggtt 4080 gtaggactgg aagaagttga aggagatagc gttctcgcgg acgacggtgg agttgcgcag 4140 ggaggagttg taggtgcact gggtggtgtt ctcgcgcagg aaacggatag gacgaccgta 4200 ggtgttcagc aggaggtgga aagccttgtc caggggctcg gagatagcct cagcaccgta 4260 acgggaggac aggaggtggg acagcaggca cacagccagc acgatcaggt aggagggcag 4320 gccgggacgc atggtggcgg atccgcgccc gatggtggga cggtatgaat aatccggaat 4380 atttataggt ttttttatta caaaactgtt acgaaaacag taaaatactt atttatttgc 4440 gagatggtta tcattttaat tatctccatg atctattaat attcccagct tcctttcggg 4500 ctttgttagc agccggatct tctaggctca agcagtgatc agatccagac atgataagat 4560 acattgatga gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg 4620 aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca 4680 acaacaattg cattcatttt atgtttcagg ttcaggggga ggtgtgggag gttttttaaa 4740 gcaagtaaaa cctctacaaa tgtggtatgg ctgattatga tctctagtac ttctcgacaa 4800 gcttggcgcg ccttagacgt tctcttcctc gtcggagtcc ttcaggtgac ggtaaccgtt 4860 cttgcggtga cgcagacggt ccagcaggtt gggcttctgg cccttgtcct gggttccggt 4920 ctggccgtcc agggagtcgg tgccgttctg ctgtgcacgc tgctcagcgt ccagacgcac 4980 gagagccagc agcatctggt aagcctgctc gttggtgtat gggggagcag cggtagaagc 5040 gtcggaggaa gggggaccgg gacccttgcg accggagttg tagacggatt cctcgtagga 5100 tgggggagcc tgcagggagg tgtccttggt gttgccggag gtcacggtag taccgtcagc 5160 ggacaccagg taggggaaca ggttctgcag gggctgcatg cacagacgac gctgacgggt 5220 gtagatcagg tagatgatga tgaccacagc gatagccacc aggatgatgg tgaaagcacc 5280 gaaggggttc ttcaggaagg tggcgacacc ctcgaccacg gaagccacag caccacccac 5340 agcaccgata gcgacaccca cagccttgcc ggcagctccc aggccggaca tcaggtcgtc 5400 cagtcccttc aggtaggggg gcagggggtc caccaccttg tcctcgacgt acttaacacg 5460 ctgcttgtag gagttgaact cgcgcatgat ctcttccagg tcgaacacgt tgatggaacg 5520 cagttccttc tgggagtaca gttccagcac acggaagtcg gtgttttcca gggggtcgat 5580 gtccagagcg atcatggagt ccacggtaga gatggaggac aggtcgatca tgcgcttgaa 5640 caggtagtcc acgtattcgt aagcggagtt gccagcgatg aagatcttca gggagggcag 5700 ctggcattcc tcggtacggt ggttgcccag caggatctcg ttgtcctcgc ccagctggcc 5760 gtactgcacg taggaggagt tagcgaagtt gaagatgacc acgggacggg agtagcaacg 5820 accgggggat tccttcacgt tcatgtcacg cagcaccttc acggaagtct ggttgatggt 5880 cacgcaggaa gccaggccca gcacgtcgcc catgaaacga gcagcgatag gcttgttgta 5940 gatggcggac aggatagcgg aggggttgat cttggacagt tccttgaaca cttccagggt 6000 acgacgctgg tccacgcacc aagcctcagc gatctgagcc agagcacggt tgatgtaacc 6060 gcgcagggtg tcgtaggtga actgcagctg agcgtacacc aggttgtgca cggattccat 6120 gttggacagg tgagtagcgt tgttgccgtc ggtggaacgc ttggtacggt tgtgggtcag 6180 gttcagggag gaacggttag ccagacgttc cagctcgacc agggacttct gcttgatacc 6240 ctgccagaac accaccaggc caccggtagt ctcgaacacg gacacgtttc cgtacttctc 6300 gtaggtctgg ttgtaggagg tgttgaagat ctgctgcagc ttgttgatag cctcgtcacg 6360 cacgcagtcc agggcggagt cggacatgtt gacctcttgt ttcttggaca ggaaggtagc 6420 ggtcatctta gcgctggaga agtggtagga gtcctcagcc tcggaacgga tggtacgctc 6480 ggaagcctcc cagaaggtca gctggcaggt cacgttcttc tcgtcctgga tgtcccagga 6540 gatcacggag tcagcacgct ccaagaaagc caccagacgg tgggtttcca gagcggagtt 6600 gggacgaccg aagtcggaca cgatggtgta gttggggaag atgaagaact tgtcagcgtt 6660 ctcgccgaag taggaagcgt tacggttagt accgttgtag aagggggaga tgtccaccac 6720 gtcgccggtg gaggtagcga agaagtggta agggtacttg gaacgagcgg tggtgatggt 6780 gaccatgcag ttcaggttgc aggtttcacg gtacagccag gtggaaccac gggagtgcca 6840 ctggtccttc acggtcacgt aacgggtgga gtgggtgttg gagtagtcgt cgggcatcag 6900 ctgcatggtc ttgttctcgt aggagtcacg gtggtaagcc acgaacacgg tgccagcgat 6960 cacacgggag taagaggagt agcactggga gtgggagttg atgtggtgga tctcccacat 7020 gggaggggcc acgtactcgg tgttggaacc cagcaggtaa gtggtgtgga tgtaagcgta 7080 ggaacgacgg aaggtcagca ccttctggta cacgcggacc ttgaaggtgt gagccacgat 7140 gttgcgcttg tacaccacca tgataccctc gtccaggtcc tcgttgatgg gcttcatgga 7200 ggtgcacacg atgttacgct cgaaacggat caggtcggtg ccctgagcca tggagcacac 7260 acggtagggg tacttggtgg tgttgacacc cacgacgtcg ccgtacttca gggtggtgtt 7320 gtagatagtc tcgttgacac cgtgggacac ggtctgggag gaggtcacac gctgggacac 7380 ggaaccggaa cgggagtgag cggcggaggt ggtgtgggag gagtggtggg agtgggtagc 7440 ggaggtgcca cgggtggagg aggaggacac agcagcaccc aggcacacga tgcacaggtt 7500 cacgcacacg accaggcacc agatacggga ttccatggtg gcgtcgacgg taggcctttg 7560 aattccgcgc gcttcggacc gggatccgcg cccgatggtg ggacggtatg aataatccgg 7620 aatatttata ggttttttta ttacaaaact gttacgaaaa cagtaaaata cttatttatt 7680 tgcgagatgg ttatcatttt aattatctcc atgatctatt aatattccgg gggttatgat 7740 agttattgct cagcggtggc agcagccaac tcagcttcct ttcgggcttt gttagcagcc 7800 ggatcttcta ggctcaagca gtgatcagat ccagacatga taagatacat tgatgagttt 7860 ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct 7920 attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt 7980 cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc 8040 tacaaatgtg gtatggctga ttatgatcct ctagtacttc tcgacaagct tttattagtt 8100 ggcgaacaga cgcacggaga actccaagga acgagcgtgg ggagccaggg aaccagcagc 8160 gttgaaggtg gtacgcttgt tggtgccacc acgacggttc tgacgacgga agtcggagat 8220 cagcagggac acctcggtca cgttgatacg cttcagcacg tcgaagttgt ccaggccgtg 8280 ggaagcgtcg tagtggtagt tcagggtcag gtccaccagc tgctcgacgt acttgtaacg 8340 ggtctggtcg ggcagagcac gggagcaagc gtcccagtag tggggcacac ggtagtagtc 8400 gttcttctca gcggtttcac gctggcactg tcccagcacc acagcgcaca ggcacacgga 8460 cagccacaca cggcacagac gcatggtggc ggatccggtg gcggatccgc gcccgatggt 8520 gggacggtat gaataatccg gaatatttat aggttttttt attacaaaac tgttacgaaa 8580 acagtaaaat acttatttat ttgcgagatg gttatcattt taattatctc catgatctat 8640 taatattccg ggcaattaat gtgagttagc tcactcatta ggcacccagc agccaactca 8700 gcttcctttc gggctttgtt agcagccgga tcttctaggc tcaagcagtg atcagatcca 8760 gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa 8820 tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat 8880 aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg 8940 gaggtttttt aaagcaagta aaacctctac aaatgtggta tggctgatta tgatcctcta 9000 gtacttctcg acaagcttgt cgacttacac gatcaggttg gggtgggtgc agaaggtgta 9060 ggtctggttg ttagcctcgg tgaaggtcag gcgcacttgg aaggacacgg agtagtcacg 9120 gaacacgtga gcccaggatt ccagcttcat cacgcacatc tggtaacggg tgccgtcgtt 9180 gaccacgaaa cgcagcagct tggtctgctt gggcaccatg tgagcaccga agatcttagc 9240 gtcctcgacg gagatctgca cgttgccgtc ggagggcttg gaagcggtac ggggcatacg 9300 ctgcaggatg gtctggttac gaccggacaa gtaccagatg accttcttga cccaggtgga 9360 ggacctctcg accagggtct ggccctcgcg gttgtacagc aggtacagag tctcgttacg 9420 gcactcggga ccggtggaca cacgctggaa accggagaac tgggatgggg aacgaggtgg 9480 ggatgggtac aggaaggggc agtagaaggt agcagcgtcg tggggcttgg ggtaggtcag 9540 cttggaccag ggtggggagg ggttctggtt agcggtcagg gtgaaccagg gggaagccag 9600 gcagggggta gcccacacag cgcacagcag caggcagtgg aagtggtgac gcagcagcag 9660 acgcagcatg gtggcggatc cgcgcccgat ggtgggacgg tatgaataat ccggaatatt 9720 tataggtttt tttattacaa aactgttacg aaaacagtaa aatacttatt tatttgcgag 9780 atggttatca ttttaattat ctccatgatc tattaatatt ccggtctaga tgtatctcct 9840 tcttaaagtt aaacaaagct agccacagca gccaactcag cttcctttcg ggctttgtta 9900 gcagccggat cttctaggct caagcagtga tcagatccag acatgataag atacattgat 9960 gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt 10020 gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat 10080 tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa 10140 aacctctaca aatgtggtat ggctgattat gatcctctag tacttctcga caagctttta 10200 ctgcagcatg taacccatct tagcacggca cacgtccaga cgcttgtgct tcttcacgga 10260 ctcgaggtac tggtccaggc ccacgatacg ggtgatcttg tcgtactcga ggttgatcca 10320 acggtagggc acggaaccag cagcacccag caggtactga gccttgtcgg acaccttgcc 10380 gcaacggata cgaccgtcag cctcgaggta cagggggttg tagttgcagc tggtcagctt 10440 gttgtggatc acttgacggg tcagggagtg ggtcatggtg gtcacgatac cacggatctc 10500 agcggtcttt tcgggggagt agcacacttc gccgtcgggg caacgcagag ccacggtgaa 10560 caggttgcac atcttgaagt cgtagcagcg ctcggggggg tggttcacgt tgatcacttc 10620 gcagcattcc tcagcacgca cacgaggcac acgggagtgg tccagcagca gccacagggt 10680 ggtcaggaag ggggtcaggt ccttggagtt catggtggcg gatccgcgcc cgatggtggg 10740 acggtatgaa taatccggaa tatttatagg tttttttatt acaaaactgt tacgaaaaca 10800 gtaaaatact tatttatttg cgagatggtt atcattttaa ttatctccat gatctattaa 10860 tattccggag taggtcgcga atcgatacta gtatacggac ctttaattca acccaacaca 10920 atatattata gttaaataag aattattatc aaatcatttg tatattaatt aaaatactat 10980 actgtaaatt acattttatt tacaatcact cgacgaagac ttgatcaccc gggatctcga 11040 gccaccatgt gccgtcgtcc cgactgcggt ttctccttct cccccggtcc cgtggctctg 11100 ctgtggtgct gcctgctgct gcccatcgtg tcctccgcta ccgtgtccgt ggctcccacc 11160 gtggctgaga aggtgcccgc tgagtgcccc gagctgaccc gtcgttgcct gctgggagag 11220 gtgttccagg gcgacaagta cgagtcctgg ctgcgtcccc tggtcaacgt gacccgtagg 11280 gacggtcccc tgtcccagct gatccgttac cgtcccgtga cccccgaggc tgctaactcc 11340 gtgctgctgg acgacgcttt cctggacacc ctggccctgc tgtacaacaa ccccgaccag 11400 ctgcgtgctc tgctgaccct gctgtcctcc gacaccgctc cccgttggat gaccgtgatg 11460 cgcggttact ccgagtgcgg cgacggttcc cccgctgtgt acacttgcgt ggacgacctg 11520 tgccgtggtt acgacctgac tcgtctgtcc tacggtcgtt ccatcttcac cgaacacgtg 11580 ctgggtttcg agctggtgcc cccctccctg ttcaacgtgg tggtggctat ccgtaacgag 11640 gctacccgta ccaaccgtgc tgtgcgtctg cccgtgtcca ccgctgctgc tcccgagggt 11700 atcaccctgt tctacggcct gtacaacgct gtgaaggaat tctgcctgcg tcaccagctg 11760 gacccccccc tgctgcgtca cctggacaag tactacgctg gcctgccccc tgagctgaag 11820 cagacccgtg tgaacctgcc cgctcactcc cgttacggtc cccaggctgt ggacgctcgc 11880 taagctagca gctgatgcat agcatgcggt accgggagat gggggaggct aactgaaaca 11940 cggaaggaga caataccgga aggaacccgc gctatgacgg caataaaaag acagaataaa 12000 acgcacgggt gttgggtcgt ttgttcataa acgcggggtt cggtcccagg gctggcactc 12060 tgtcgatacc ccaccgagac cccattggga ccaatacgcc cgcgtttctt ccttttcccc 12120 accccaaccc ccaagttcgg gtgaaggccc agggctcgca gccaacgtcg gggcggcaag 12180 ccctgccata gccactacgg gtacgtttaa accagataac ttcgtataat gtatgctata 12240 cgaagttatg gtaccgcggc cgcgtagagg atctgttgat cagcagttca acctgttgat 12300 agtacaaaca aagctgtagc caaccactag aactatagct agagtcctgg gcgaacaaac 12360 gatgctcgcc ttccagaaaa ccgaggatgc gaaccacttc atccggggtc agcaccaccg 12420 gcaagcgccg cgacggccga ggtctaccga tctcctgaag caagggcaga tccgtgcaca 12480 gcaccttgcc gtagaagaac agcaaggccg ccaatgcctg acgatgcgtg gagaccgaaa 12540 ccttgcgctc gttcgccagc caggacagaa atgcctcgac ttcgctgctg cccaaggttg 12600 ccgggtgacg cacaccgtgg aaacggatga aggcacaaac ccagttgaca taagcctgtt 12660 cggttcgtaa actgtaatgc aagtagcgta tgcgctcacg caactggtcc agaaccttga 12720 ccgaacgcag cggtggtaac ggcgcagtgg cggttttcat ggcttgttat gactgttttt 12780 ttgtacagtc tatgcctcgg gcatccaagc agcaagcgcg ttacgccgtg ggtcgatgtt 12840 tgatgttatg gagcagcaac gatgttacgc agcagcaacg atgttacgca gcagggcagt 12900 cgccctaaaa caaagttagg tggctcaagt atgggcatca ttcgcacatg taggctcggc 12960 cctgaccaag tcaaatccat gcgggctgct cttgatcttt tcggtcgtga gttcggagac 13020 gtagccacct actcccaaca tcagccggac tccgattacc tcgggaactt gctccgtagt 13080 aagacattca tcgcgcttgc tgccttcgac caagaagcgg ttgttggcgc tctcgcggct 13140 tacgttctgc ccaagtttga gcagccgcgt agtgagatct atatctatga tctcgcagtc 13200 tccggcgagc accggaggca gggcattgcc accgcgctca tcaatctcct caagcatgag 13260 gccaacgcgc ttggtgctta tgtgatctac gtgcaagcag attacggtga cgatcccgca 13320 gtggctctct atacaaagtt gggcatacgg gaagaagtga tgcactttga tatcgaccca 13380 agtaccgcca cctaacaatt cgttcaagcc gagatcggct tcccggccgc ggagttgttc 13440 ggtaaattgt cacaacgccg cgaatatagt ctttaccatg cccttggcca cgcccctctt 13500 taatacgacg ggcaatttgc acttcagaaa atgaagagtt tgctttagcc ataacaaaag 13560 tccagtatgc tttttcacag cataactgga ctgatttcag tttacaacta ttctgtctag 13620 tttaagactt tattgtcata gtttagatct attttgttca gtttaagact ttattgtccg 13680 cccacacccg cttacgcagg gcatccattt attactcaac cgtaaccgat tttgccaggt 13740 tacgcggctg gtctatgcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg 13800 cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga 13860 agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggacgcg 13920 ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca 13980 cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc 14040 gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct 14100 ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg 14160 ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc 14220 ttgttccaaa ctggaacaa 14239 <210> 31 <211> 15957 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 31 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttag cgagcgtcca cagcctgggg accgtaacgg gagtgagcgg 2400 gcaggttcac acgggtctgc ttcagctcag ggggcaggcc agcgtagtac ttgtccaggt 2460 gacgcagcag gggggggtcc agctggtgac gcaggcagaa ttccttcaca gcgttgtaca 2520 ggccgtagaa cagggtgata ccctcgggag cagcagcggt ggacacgggc agacgcacag 2580 cacggttggt acgggtagcc tcgttacgga tagccaccac cacgttgaac agggaggggg 2640 gcaccagctc gaaacccagc acgtgttcgg tgaagatgga acgaccgtag gacagacgag 2700 tcaggtcgta accacggcac aggtcgtcca cgcaagtgta cacagcgggg gaaccgtcgc 2760 cgcactcgga gtaaccgcgc atcacggtca tccaacgggg agcggtgtcg gaggacagca 2820 gggtcagcag agcacgcagc tggtcggggt tgttgtacag cagggccagg gtgtccagga 2880 aagcgtcgtc cagcagcacg gagttagcag cctcgggggt cacgggacgg taacggatca 2940 gctgggacag gggaccgtcc ctacgggtca cgttgaccag gggacgcagc caggactcgt 3000 acttgtcgcc ctggaacacc tctcccagca ggcaacgacg ggtcagctcg gggcactcag 3060 cgggcacctt ctcagccacg gtgggagcca cggacacggt agcggaggac acgatgggca 3120 gcagcaggca gcaccacagc agagccacgg gaccggggga gaaggagaaa ccgcagtcgg 3180 gacgacggca catggtggct cgagatcccg ggtgatcaag tcttcgtcga gtgattgtaa 3240 ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg ataataattc 3300 ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact agtatcgatt 3360 cgcgacctac tccggaatat taatagatca tggagataat taaaatgata accatctcgc 3420 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 3480 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgt cccccaagaa 3540 cctgaccccc ttcctgaccg ctctgtggct gctgctgggc cactcccgtg tgcctcgtgt 3600 gcgtgctgag gaatgctgcg agttcatcaa cgtgaaccac ccccccgagc gctgctacga 3660 cttcaagatg tgcaaccgtt tcaccgtggc tctgcgttgc cccgacggcg aagtgtgcta 3720 ctcccccgaa aagaccgctg agatccgtgg tatcgtgacc accatgaccc actccctgac 3780 ccgtcaggtg gtgcacaaca agctgacctc ttgcaactac aaccccctgt acctcgaggc 3840 tgacggtcgt atccgttgcg gcaaggtcaa cgacaaggct cagtacctgc tgggtgctgc 3900 tggttccgtg ccctaccgtt ggatcaacct cgagtacgac aagatcaccc gtatcgtggg 3960 cctggaccag tacctcgagt ccgtgaagaa gcacaagcgt ctggacgtgt gccgtgctaa 4020 gatgggttac atgctgcagt aaaagcttgt cgagaagtac tagaggatca taatcagcca 4080 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 4140 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 4200 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4260 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 4320 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 4380 gctttgttta actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga 4440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 4500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 4560 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 4620 tgtgtgggct accccctgcc tggcttcccc ttggtccacc ctgaccgcta accagaaccc 4680 ctccccaccc tggtccaagc tgacctactc caagccccac gacgctgcta ccttctactg 4740 ccccttcctg tacccatccc cccctcgttc cccactgcag ttctccggtt tccagcgtgt 4800 gctgaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 4860 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 4920 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 4980 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 5040 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctcga 5100 gtcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 5160 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaaaagct 5220 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 5280 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 5340 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 5400 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 5460 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 5520 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 5580 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 5640 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 5700 ttcataccgt cccaccatcg ggcgcggatc cgccaccatg cgtctgtgcc gtgtgtggct 5760 gtccgtgtgc ctgtgcgctg tggtgctggg ccagtgccag cgtgaaaccg ctgagaagaa 5820 cgactactac cgtgtgcccc actactggga cgcttgctcc cgtgctctgc ccgaccagac 5880 ccgttacaag tacgtcgagc agctggtgga cctgaccctg aactaccact acgacgcttc 5940 ccacggcctg gacaacttcg acgtgctgaa gcgtatcaac gtgaccgagg tgtccctgct 6000 gatctccgac ttccgtcgtc agaaccgtcg tggtggcacc aacaagcgta ccaccttcaa 6060 cgctgctggt tccctggctc cccacgctcg ttccctcgag ttctccgtgc gtctgttcgc 6120 taactaaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 6180 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 6240 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 6300 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 6360 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 6420 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 6480 cataaccccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 6540 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 6600 ggattattca taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattca 6660 aaggcctacc gtcgacgcca ccatggaatc ccgtatctgg tgcctggtcg tgtgcgtgaa 6720 cctgtgcatc gtgtgcctgg gtgctgctgt gtcctcctcc tccacccgtg gcacctccgc 6780 tacccactcc caccactcct cccacaccac ctccgccgct cactcccgtt ccggttccgt 6840 gtcccagcgt gtgacctcct cccagaccgt gtcccacggt gtcaacgaga ctatctacaa 6900 caccaccctg aagtacggcg acgtcgtggg tgtcaacacc accaagtacc cctaccgtgt 6960 gtgctccatg gctcagggca ccgacctgat ccgtttcgag cgtaacatcg tgtgcacctc 7020 catgaagccc atcaacgagg acctggacga gggtatcatg gtggtgtaca agcgcaacat 7080 cgtggctcac accttcaagg tccgcgtgta ccagaaggtg ctgaccttcc gtcgttccta 7140 cgcttacatc cacaccactt acctgctggg ttccaacacc gagtacgtgg cccctcccat 7200 gtgggagatc caccacatca actcccactc ccagtgctac tcctcttact cccgtgtgat 7260 cgctggcacc gtgttcgtgg cttaccaccg tgactcctac gagaacaaga ccatgcagct 7320 gatgcccgac gactactcca acacccactc cacccgttac gtgaccgtga aggaccagtg 7380 gcactcccgt ggttccacct ggctgtaccg tgaaacctgc aacctgaact gcatggtcac 7440 catcaccacc gctcgttcca agtaccctta ccacttcttc gctacctcca ccggcgacgt 7500 ggtggacatc tcccccttct acaacggtac taaccgtaac gcttcctact tcggcgagaa 7560 cgctgacaag ttcttcatct tccccaacta caccatcgtg tccgacttcg gtcgtcccaa 7620 ctccgctctg gaaacccacc gtctggtggc tttcttggag cgtgctgact ccgtgatctc 7680 ctgggacatc caggacgaga agaacgtgac ctgccagctg accttctggg aggcttccga 7740 gcgtaccatc cgttccgagg ctgaggactc ctaccacttc tccagcgcta agatgaccgc 7800 taccttcctg tccaagaaac aagaggtcaa catgtccgac tccgccctgg actgcgtgcg 7860 tgacgaggct atcaacaagc tgcagcagat cttcaacacc tcctacaacc agacctacga 7920 gaagtacgga aacgtgtccg tgttcgagac taccggtggc ctggtggtgt tctggcaggg 7980 tatcaagcag aagtccctgg tcgagctgga acgtctggct aaccgttcct ccctgaacct 8040 gacccacaac cgtaccaagc gttccaccga cggcaacaac gctactcacc tgtccaacat 8100 ggaatccgtg cacaacctgg tgtacgctca gctgcagttc acctacgaca ccctgcgcgg 8160 ttacatcaac cgtgctctgg ctcagatcgc tgaggcttgg tgcgtggacc agcgtcgtac 8220 cctggaagtg ttcaaggaac tgtccaagat caacccctcc gctatcctgt ccgccatcta 8280 caacaagcct atcgctgctc gtttcatggg cgacgtgctg ggcctggctt cctgcgtgac 8340 catcaaccag acttccgtga aggtgctgcg tgacatgaac gtgaaggaat cccccggtcg 8400 ttgctactcc cgtcccgtgg tcatcttcaa cttcgctaac tcctcctacg tgcagtacgg 8460 ccagctgggc gaggacaacg agatcctgct gggcaaccac cgtaccgagg aatgccagct 8520 gccctccctg aagatcttca tcgctggcaa ctccgcttac gaatacgtgg actacctgtt 8580 caagcgcatg atcgacctgt cctccatctc taccgtggac tccatgatcg ctctggacat 8640 cgaccccctg gaaaacaccg acttccgtgt gctggaactg tactcccaga aggaactgcg 8700 ttccatcaac gtgttcgacc tggaagagat catgcgcgag ttcaactcct acaagcagcg 8760 tgttaagtac gtcgaggaca aggtggtgga ccccctgccc ccctacctga agggactgga 8820 cgacctgatg tccggcctgg gagctgccgg caaggctgtg ggtgtcgcta tcggtgctgt 8880 gggtggtgct gtggcttccg tggtcgaggg tgtcgccacc ttcctgaaga accccttcgg 8940 tgctttcacc atcatcctgg tggctatcgc tgtggtcatc atcatctacc tgatctacac 9000 ccgtcagcgt cgtctgtgca tgcagcccct gcagaacctg ttcccctacc tggtgtccgc 9060 tgacggtact accgtgacct ccggcaacac caaggacacc tccctgcagg ctcccccatc 9120 ctacgaggaa tccgtctaca actccggtcg caagggtccc ggtccccctt cctccgacgc 9180 ttctaccgct gctcccccat acaccaacga gcaggcttac cagatgctgc tggctctcgt 9240 gcgtctggac gctgagcagc gtgcacagca gaacggcacc gactccctgg acggccagac 9300 cggaacccag gacaagggcc agaagcccaa cctgctggac cgtctgcgtc accgcaagaa 9360 cggttaccgt cacctgaagg actccgacga ggaagagaac gtctaaggcg cgccaagctt 9420 gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 9480 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 9540 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 9600 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 9660 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9720 cgaaaggaag ctgggaatat taatagatca tggagataat taaaatgata accatctcgc 9780 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 9840 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgc gtcccggcct 9900 gccctcctac ctgatcgtgc tggctgtgtg cctgctgtcc cacctcctgt cctcccgtta 9960 cggtgctgag gctatctccg agcccctgga caaggctttc cacctcctgc tgaacaccta 10020 cggtcgtcct atccgtttcc tgcgcgagaa caccacccag tgcacctaca actcctccct 10080 gcgcaactcc accgtcgtcc gcgagaacgc tatctccttc aacttcttcc agtcctacaa 10140 ccagtactac gtgttccaca tgccccgttg cctgttcgct ggtcccctgg ctgagcagtt 10200 cctgaaccag gtggacctga ccgagactct cgagcgttac cagcagcgtc tgaacactta 10260 cgctctggtg tccaaggacc tggcttccta ccgttccttc agccagcagc tgaaggctca 10320 ggactccctg ggcgagcagc ccaccactgt gcctccccct atcgacctgt ccatccccca 10380 cgtgtggatg cccccccaga ccactcctca cggctggacc gagtcccaca ccacctccgg 10440 actgcaccgt ccccacttca accagacctg catcctgttc gacggtcacg acctgctgtt 10500 ctccaccgtg accccctgcc tgcaccaggg cttctacctc atcgacgagc tgcgttacgt 10560 gaagatcacc ctgaccgagg atttcttcgt ggtcaccgtg tccatcgacg acgacacccc 10620 catgctgctg atcttcggtc acctcccccg tgtgctgttc aaggctccct accagcgtga 10680 caacttcatc ctgcgtcaga ccgagaagca cgagctgctg gtgctggtca agaaggacca 10740 gctgaaccgt cactcttacc tgaaggaccc cgacttcctg gacgctgctc tggacttcaa 10800 ctacctggac ctgtccgctc tgctgaggaa ctccttccac cgttacgctg tggacgtgct 10860 gaagtccggt cgttgccaga tgctggaccg tcgtaccgtc gagatggctt tcgcttacgc 10920 cctggctctg ttcgctgctg ctcgtcaaga agaggctggc gctcaggtgt ccgtgccccg 10980 tgctctggac cgtcaggctg ctctgctgca gatccaagag ttcatgatca cttgcctgtc 11040 ccagaccccc cctcgtacca ccctgctgct gtaccccacc gctgtggacc tggctaagcg 11100 tgctctgtgg acccccaacc agatcaccga catcacctcc ctcgtgcgtc tggtgtacat 11160 cctgtccaag cagaaccagc agcacctgat cccccagtgg gctctgcgtc agatcgctga 11220 cttcgctctg aagctgcaca agacccacct ggcttcattc ctcagcgctt tcgctcgcca 11280 agagctgtac ctgatgggtt ccctggtgca ctccatgctg gtgcacacca ccgagcgtcg 11340 cgagatcttc atcgtggaaa ccggcctgtg ctccctggcc gagctgtccc acttcaccca 11400 gctgctggct cacccccacc acgagtacct gtccgacctg tacaccccct gctcctcttc 11460 cggtcgtcgt gaccactccc tggaacgtct gacccgtctg ttccccgacg ctaccgtgcc 11520 taccaccgtg cctgctgctc tgtccatcct gtctaccatg cagccctcca ccctggaaac 11580 cttccccgac ctgttctgcc tgcctctggg cgagtccttc tccgctctga ccgtgtccga 11640 gcacgtgtcc tacgtggtca ccaaccagta cctgatcaag ggcatctcct accccgtgtc 11700 caccaccgtc gtgggccagt ccctgatcat cacccagacc gactcccaga ccaagtgcga 11760 gctgacccgt aacatgcaca ccactcactc catcaccgct gctctgaaca tctccctcga 11820 gaactgcgct ttctgccagt ccgctctgtt ggagtacgac gacactcagg gtgtcatcaa 11880 catcatgtac atgcacgact ccgacgacgt gctgttcgct ctggacccct acaacgaggt 11940 ggtggtgtcc tccccccgta cccactacct gatgctgctg aagaacggca ccgtgctgga 12000 agtgaccgac gtggtggtgg acgctaccga ccgtctgctg atgatgtccg tgtacgctct 12060 gtccgctatc atcggcatct acctgctgta ccgtatgctg aagacctgcc agctgttgaa 12120 ttttgacctt cttaagcttg cgggagacgt cgagtccaac cctgggccca tgggtgctcg 12180 tgcttcagtg ctgtccggtg gcgagctgga caagtgggag aagatccgtc tgcgtcccgg 12240 tggcaagaag cagtacaagc tgaagcacat cgtgtgggct tcccgcgagc tggaacgttt 12300 cgctgtgaac cccggcctgc tggaaacctc cgagggttgc cgtcagatcc tgggccagct 12360 gcagccctcc ctgcagaccg gttccgagga actgcgttcc ctgtacaaca ctatcgctgt 12420 gctgtactgc gtgcaccagc gtatcgacgt gaaggacacc aaggaagctc tggacaagat 12480 cgaggaagaa cagaacaagt ccaagaagaa ggcccagcag gctgctgctg acaccggcaa 12540 caactcccag gtgtcccaga actaccccat cgtgcagaac ctgcagggcc agatggtgca 12600 ccaggctatc tccccccgta ccctgaacgc ttgggtcaag gtggtggaag agaaggcttt 12660 cagccccgaa gtgatcccca tgttctccgc tctgtccgag ggtgctaccc cccaggacct 12720 gaacaccatg ctgaacaccg tgggtggtca ccaggctgct atgcagatgc tgaaggaaac 12780 catcaacgaa gaggctgctg agtgggaccg tctgcacccc gtgcacgctg gtcctatcgc 12840 tcccggacag atgcgcgagc cccgtggttc cgacatcgct ggaaccacct ccaccctgca 12900 agagcagatc ggctggatga cccacaaccc ccccatcccc gtgggcgaga tctacaagcg 12960 ttggatcatc ctgggcctga acaagatcgt gcgtatgtac tcccccacct ccatcctgga 13020 catccgtcag ggtcccaagg aacccttccg tgactacgtg gaccgtttct acaagaccct 13080 gcgtgccgag caggcttccc aagaggtcaa gaactggatg accgagactc tgctggtgca 13140 gaacgctaac cccgactgca agaccatcct gaaggctctg ggtcccggtg ctaccctgga 13200 agagatgatg accgcttgcc agggtgtcgg tggtcccggt cacaaggctc gtgtgctggc 13260 tgaggctatg tcccaagtga ccaaccccgc taccatcatg atccagaagg gcaacttccg 13320 taaccagcgc aagaccgtga agtgcttcaa ctgcggcaag gaaggccaca tcgctaagaa 13380 ctgccgtgct ccccgcaaga agggctgctg gaagtgcgga aaggaaggac accagatgaa 13440 ggactgcacc gagcgtcagg ctaacttcct gggcaagatc tggccctccc acaagggtcg 13500 tcccggcaac ttcctgcagt cccgtcccga gcccaccgct cccccagagg aatccttccg 13560 tttcggcgag gaaaccacca ccccatccca gaagcaagag cccatcgaca aggaactgta 13620 ccccctggct tccctgcgct ccctgttcgg ttccgaccca tcctcccagc agctgttgaa 13680 ttttgacctt cttaagcttg cgggagacgt cgtcgagtcc aaccctgggc ccatggaatc 13740 ccgtggtcgt cgttgccccg agatgatctc cgtgctgggt cccatctccg gtcacgtcct 13800 gaaggctgtg ttctcccgtg gcgacacccc cgtgctgccc cacgaaactc gtctgctgca 13860 gaccggtatc cacgtgcgtg tgtcccagcc ctccctgatc ctggtgtccc agtacacccc 13920 cgactccacc ccttgccacc gcggagacaa ccagctgcag gtccagcaca cctacttcac 13980 cggttccgag gtcgagaacg tgtccgtgaa cgtgcacaac cccaccggtc gttccatctg 14040 cccctcccaa gagcccatgt ccatctacgt gtacgctctg cccctgaaga tgctgaacat 14100 cccctccatc aacgtgcacc actacccctc cgctgctgag cgcaagcacc gtcacctccc 14160 cgtggctgac gctgtgatcc acgcttccgg caagcagatg tggcaggctc gtctgaccgt 14220 gtccggcctg gcttggaccc gtcagcagaa ccagtggaag gaacccgacg tgtactacac 14280 ctccgctttc gtgttcccca ccaaggacgt ggccctgcgt cacgtcgtgt gcgctcacga 14340 actcgtgtgc tccatggaaa acacccgtgc taccaagatg caagtgatcg gcgaccagta 14400 cgtgaaggtg tacctggaat ccttctgcga ggacgtgccc tccggcaagc tgttcatgca 14460 cgtgaccctg ggttccgacg tggaagagga cctgaccatg acccgtaacc cccagccctt 14520 catgcgtccc cacgagcgta acggtttcac cgtgctgtgc cccaagaaca tgatcatcaa 14580 gcccggcaag atctcccaca tcatgctgga cgtggccttc acctcccacg agcacttcgg 14640 cctgctgtgc cctaagtcca tccccggcct gtccatctcc ggcaacctgc tgatgaacgg 14700 ccagcagatc ttcctggaag tgcaggctat ccgtgaaacc gtcgagctgc gtcagtacga 14760 ccctgtggct gctctgttct tcttcgacat cgacctgctg ctgcagcgtg gtccccagta 14820 ctccgagcac cccaccttca ccagccagta ccgtatccag ggcaagctgg aataccgtca 14880 cacctgggac cgtcacgacg agggtgctgc tcagggcgac gacgacgtgt ggacctccgg 14940 ttccgactcc gacgaggaac tggtcaccac cgagcgcaag accccccgtg tgaccggtgg 15000 tggtgctatg gctggtgctt ccacctccgc tggtcgcaag cgcaagtccg cttcctccgc 15060 taccgcttgc accgctggtg tcatgacccg tggtcgcctg aaggctgagt ccaccgtggc 15120 tcccgaagag gacactgacg aggactccga caacgagatc cacaaccccg ctgtgttcac 15180 ctggcccccc tggcaggctg gtatcctggc tcgtaacctg gtgcccatgg tggctaccgt 15240 gcagggccag aacctgaagt accaagagtt cttctgggac gccaacgaca tctaccgtat 15300 cttcgctgag ctggaaggcg tgtggcagcc cgctgctcag cccaagcgtc gtcgtcaccg 15360 tcaggacgct ctgcctggtc cctgtatcgc ttccaccccc aagaagcacc gcggctaaaa 15420 gcttgtcgag aagtactaga ggatcataat cagccatacc acatttgtag aggttttact 15480 tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt 15540 tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa 15600 tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa 15660 tgtatcttat catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca 15720 aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta tcataacccc 15780 taggagatcc gaaccagata agtgaaatct agttccaaac tattttgtca tttttaattt 15840 tcgtattagc ttacgacgct acacccagtt cccatctatt ttgtcactct tccctaaata 15900 atccttaaaa actccatttc cacccctccc agttcccaac tattttgtcc gcccaca 15957 <210> 32 <211> 15957 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 32 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttag cgagcgtcca cagcctgggg accgtaacgg gagtgagcgg 2400 gcaggttcac acgggtctgc ttcagctcag ggggcaggcc agcgtagtac ttgtccaggt 2460 gacgcagcag gggggggtcc agctggtgac gcaggcagaa ttccttcaca gcgttgtaca 2520 ggccgtagaa cagggtgata ccctcgggag cagcagcggt ggacacgggc agacgcacag 2580 cacggttggt acgggtagcc tcgttacgga tagccaccac cacgttgaac agggaggggg 2640 gcaccagctc gaaacccagc acgtgttcgg tgaagatgga acgaccgtag gacagacgag 2700 tcaggtcgta accacggcac aggtcgtcca cgcaagtgta cacagcgggg gaaccgtcgc 2760 cgcactcgga gtaaccgcgc atcacggtca tccaacgggg agcggtgtcg gaggacagca 2820 gggtcagcag agcacgcagc tggtcggggt tgttgtacag cagggccagg gtgtccagga 2880 aagcgtcgtc cagcagcacg gagttagcag cctcgggggt cacgggacgg taacggatca 2940 gctgggacag gggaccgtcc ctacgggtca cgttgaccag gggacgcagc caggactcgt 3000 acttgtcgcc ctggaacacc tctcccagca ggcaacgacg ggtcagctcg gggcactcag 3060 cgggcacctt ctcagccacg gtgggagcca cggacacggt agcggaggac acgatgggca 3120 gcagcaggca gcaccacagc agagccacgg gaccggggga gaaggagaaa ccgcagtcgg 3180 gacgacggca catggtggct cgagatcccg ggtgatcaag tcttcgtcga gtgattgtaa 3240 ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg ataataattc 3300 ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact agtatcgatt 3360 cgcgacctac tccggaatat taatagatca tggagataat taaaatgata accatctcgc 3420 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 3480 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatga actccaagga 3540 cctgaccccc ttcctgacca ccctgtggct gctgctggac cactcccgtg tgcctcgtgt 3600 gcgtgctgag gaatgctgcg aagtgatcaa cgtgaaccac ccccccgagc gctgctacga 3660 cttcaagatg tgcaacctgt tcaccgtggc tctgcgttgc cccgacggcg aagtgtgcta 3720 ctcccccgaa aagaccgctg agatccgtgg tatcgtgacc accatgaccc actccctgac 3780 ccgtcaagtg atccacaaca agctgaccag ctgcaactac aaccccctgt acctcgaggc 3840 tgacggtcgt atccgttgcg gcaaggtgtc cgacaaggct cagtacctgc tgggtgctgc 3900 tggttccgtg ccctaccgtt ggatcaacct cgagtacgac aagatcaccc gtatcgtggg 3960 cctggaccag tacctcgagt ccgtgaagaa gcacaagcgt ctggacgtgt gccgtgctaa 4020 gatgggttac atgctgcagt aaaagcttgt cgagaagtac tagaggatca taatcagcca 4080 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 4140 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 4200 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4260 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 4320 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 4380 gctttgttta actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga 4440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 4500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 4560 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 4620 tgtgtgggct accccctgcc tggcttcccc ttggtccacc ctgaccgcta accagaaccc 4680 ctccccaccc tggtccaagc tgacctactc caagccccac gacgctgcta ccttctactg 4740 ccccttcctg tacccatccc cccctcgttc cccactgcag ttctccggtt tccagcgtgt 4800 gctgaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 4860 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 4920 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 4980 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 5040 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctcga 5100 gtcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 5160 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaaaagct 5220 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 5280 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 5340 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 5400 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 5460 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 5520 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 5580 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 5640 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 5700 ttcataccgt cccaccatcg ggcgcggatc cgccaccatg cgtctgtgcc gtgtgtggct 5760 gtccgtgtgc ctgtgcgctg tggtgctggg ccagtgccag cgtgaaaccg ctgagaagaa 5820 cgactactac cgtgtgcccc actactggga cgcttgctcc cgtgctctgc ccgaccagac 5880 ccgttacaag tacgtcgagc agctggtgga cctgaccctg aactaccact acgacgcttc 5940 ccacggcctg gacaacttcg acgtgctgaa gcgtatcaac gtgaccgagg tgtccctgct 6000 gatctccgac ttccgtcgtc agaaccgtcg tggtggcacc aacaagcgta ccaccttcaa 6060 cgctgctggt tccctggctc cccacgctcg ttccctcgag ttctccgtgc gtctgttcgc 6120 taactaaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 6180 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 6240 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 6300 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 6360 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 6420 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 6480 cataaccccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 6540 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 6600 ggattattca taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattca 6660 aaggcctacc gtcgacgcca ccatggaatc ccgtatctgg tgcctggtcg tgtgcgtgaa 6720 cctgtgcatc gtgtgcctgg gtgctgctgt gtcctcctcc tccacccgtg gcacctccgc 6780 tacccactcc caccactcct cccacaccac ctccgccgct cactcccgtt ccggttccgt 6840 gtcccagcgt gtgacctcct cccagaccgt gtcccacggt gtcaacgaga ctatctacaa 6900 caccaccctg aagtacggcg acgtcgtggg tgtcaacacc accaagtacc cctaccgtgt 6960 gtgctccatg gctcagggca ccgacctgat ccgtttcgag cgtaacatcg tgtgcacctc 7020 catgaagccc atcaacgagg acctggacga gggtatcatg gtggtgtaca agcgcaacat 7080 cgtggctcac accttcaagg tccgcgtgta ccagaaggtg ctgaccttcc gtcgttccta 7140 cgcttacatc cacaccactt acctgctggg ttccaacacc gagtacgtgg cccctcccat 7200 gtgggagatc caccacatca actcccactc ccagtgctac tcctcttact cccgtgtgat 7260 cgctggcacc gtgttcgtgg cttaccaccg tgactcctac gagaacaaga ccatgcagct 7320 gatgcccgac gactactcca acacccactc cacccgttac gtgaccgtga aggaccagtg 7380 gcactcccgt ggttccacct ggctgtaccg tgaaacctgc aacctgaact gcatggtcac 7440 catcaccacc gctcgttcca agtaccctta ccacttcttc gctacctcca ccggcgacgt 7500 ggtggacatc tcccccttct acaacggtac taaccgtaac gcttcctact tcggcgagaa 7560 cgctgacaag ttcttcatct tccccaacta caccatcgtg tccgacttcg gtcgtcccaa 7620 ctccgctctg gaaacccacc gtctggtggc tttcttggag cgtgctgact ccgtgatctc 7680 ctgggacatc caggacgaga agaacgtgac ctgccagctg accttctggg aggcttccga 7740 gcgtaccatc cgttccgagg ctgaggactc ctaccacttc tccagcgcta agatgaccgc 7800 taccttcctg tccaagaaac aagaggtcaa catgtccgac tccgccctgg actgcgtgcg 7860 tgacgaggct atcaacaagc tgcagcagat cttcaacacc tcctacaacc agacctacga 7920 gaagtacgga aacgtgtccg tgttcgagac taccggtggc ctggtggtgt tctggcaggg 7980 tatcaagcag aagtccctgg tcgagctgga acgtctggct aaccgttcct ccctgaacct 8040 gacccacaac cgtaccaagc gttccaccga cggcaacaac gctactcacc tgtccaacat 8100 ggaatccgtg cacaacctgg tgtacgctca gctgcagttc acctacgaca ccctgcgcgg 8160 ttacatcaac cgtgctctgg ctcagatcgc tgaggcttgg tgcgtggacc agcgtcgtac 8220 cctggaagtg ttcaaggaac tgtccaagat caacccctcc gctatcctgt ccgccatcta 8280 caacaagcct atcgctgctc gtttcatggg cgacgtgctg ggcctggctt cctgcgtgac 8340 catcaaccag acttccgtga aggtgctgcg tgacatgaac gtgaaggaat cccccggtcg 8400 ttgctactcc cgtcccgtgg tcatcttcaa cttcgctaac tcctcctacg tgcagtacgg 8460 ccagctgggc gaggacaacg agatcctgct gggcaaccac cgtaccgagg aatgccagct 8520 gccctccctg aagatcttca tcgctggcaa ctccgcttac gaatacgtgg actacctgtt 8580 caagcgcatg atcgacctgt cctccatctc taccgtggac tccatgatcg ctctggacat 8640 cgaccccctg gaaaacaccg acttccgtgt gctggaactg tactcccaga aggaactgcg 8700 ttccatcaac gtgttcgacc tggaagagat catgcgcgag ttcaactcct acaagcagcg 8760 tgttaagtac gtcgaggaca aggtggtgga ccccctgccc ccctacctga agggactgga 8820 cgacctgatg tccggcctgg gagctgccgg caaggctgtg ggtgtcgcta tcggtgctgt 8880 gggtggtgct gtggcttccg tggtcgaggg tgtcgccacc ttcctgaaga accccttcgg 8940 tgctttcacc atcatcctgg tggctatcgc tgtggtcatc atcatctacc tgatctacac 9000 ccgtcagcgt cgtctgtgca tgcagcccct gcagaacctg ttcccctacc tggtgtccgc 9060 tgacggtact accgtgacct ccggcaacac caaggacacc tccctgcagg ctcccccatc 9120 ctacgaggaa tccgtctaca actccggtcg caagggtccc ggtccccctt cctccgacgc 9180 ttctaccgct gctcccccat acaccaacga gcaggcttac cagatgctgc tggctctcgt 9240 gcgtctggac gctgagcagc gtgcacagca gaacggcacc gactccctgg acggccagac 9300 cggaacccag gacaagggcc agaagcccaa cctgctggac cgtctgcgtc accgcaagaa 9360 cggttaccgt cacctgaagg actccgacga ggaagagaac gtctaaggcg cgccaagctt 9420 gtcgagaagt actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 9480 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 9540 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 9600 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 9660 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 9720 cgaaaggaag ctgggaatat taatagatca tggagataat taaaatgata accatctcgc 9780 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 9840 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatgc gtcccggcct 9900 gccctcctac ctgatcgtgc tggctgtgtg cctgctgtcc cacctcctgt cctcccgtta 9960 cggtgctgag gctatctccg agcccctgga caaggctttc cacctcctgc tgaacaccta 10020 cggtcgtcct atccgtttcc tgcgcgagaa caccacccag tgcacctaca actcctccct 10080 gcgcaactcc accgtcgtcc gcgagaacgc tatctccttc aacttcttcc agtcctacaa 10140 ccagtactac gtgttccaca tgccccgttg cctgttcgct ggtcccctgg ctgagcagtt 10200 cctgaaccag gtggacctga ccgagactct cgagcgttac cagcagcgtc tgaacactta 10260 cgctctggtg tccaaggacc tggcttccta ccgttccttc agccagcagc tgaaggctca 10320 ggactccctg ggcgagcagc ccaccactgt gcctccccct atcgacctgt ccatccccca 10380 cgtgtggatg cccccccaga ccactcctca cggctggacc gagtcccaca ccacctccgg 10440 actgcaccgt ccccacttca accagacctg catcctgttc gacggtcacg acctgctgtt 10500 ctccaccgtg accccctgcc tgcaccaggg cttctacctc atcgacgagc tgcgttacgt 10560 gaagatcacc ctgaccgagg atttcttcgt ggtcaccgtg tccatcgacg acgacacccc 10620 catgctgctg atcttcggtc acctcccccg tgtgctgttc aaggctccct accagcgtga 10680 caacttcatc ctgcgtcaga ccgagaagca cgagctgctg gtgctggtca agaaggacca 10740 gctgaaccgt cactcttacc tgaaggaccc cgacttcctg gacgctgctc tggacttcaa 10800 ctacctggac ctgtccgctc tgctgaggaa ctccttccac cgttacgctg tggacgtgct 10860 gaagtccggt cgttgccaga tgctggaccg tcgtaccgtc gagatggctt tcgcttacgc 10920 cctggctctg ttcgctgctg ctcgtcaaga agaggctggc gctcaggtgt ccgtgccccg 10980 tgctctggac cgtcaggctg ctctgctgca gatccaagag ttcatgatca cttgcctgtc 11040 ccagaccccc cctcgtacca ccctgctgct gtaccccacc gctgtggacc tggctaagcg 11100 tgctctgtgg acccccaacc agatcaccga catcacctcc ctcgtgcgtc tggtgtacat 11160 cctgtccaag cagaaccagc agcacctgat cccccagtgg gctctgcgtc agatcgctga 11220 cttcgctctg aagctgcaca agacccacct ggcttcattc ctcagcgctt tcgctcgcca 11280 agagctgtac ctgatgggtt ccctggtgca ctccatgctg gtgcacacca ccgagcgtcg 11340 cgagatcttc atcgtggaaa ccggcctgtg ctccctggcc gagctgtccc acttcaccca 11400 gctgctggct cacccccacc acgagtacct gtccgacctg tacaccccct gctcctcttc 11460 cggtcgtcgt gaccactccc tggaacgtct gacccgtctg ttccccgacg ctaccgtgcc 11520 taccaccgtg cctgctgctc tgtccatcct gtctaccatg cagccctcca ccctggaaac 11580 cttccccgac ctgttctgcc tgcctctggg cgagtccttc tccgctctga ccgtgtccga 11640 gcacgtgtcc tacgtggtca ccaaccagta cctgatcaag ggcatctcct accccgtgtc 11700 caccaccgtc gtgggccagt ccctgatcat cacccagacc gactcccaga ccaagtgcga 11760 gctgacccgt aacatgcaca ccactcactc catcaccgct gctctgaaca tctccctcga 11820 gaactgcgct ttctgccagt ccgctctgtt ggagtacgac gacactcagg gtgtcatcaa 11880 catcatgtac atgcacgact ccgacgacgt gctgttcgct ctggacccct acaacgaggt 11940 ggtggtgtcc tccccccgta cccactacct gatgctgctg aagaacggca ccgtgctgga 12000 agtgaccgac gtggtggtgg acgctaccga ccgtctgctg atgatgtccg tgtacgctct 12060 gtccgctatc atcggcatct acctgctgta ccgtatgctg aagacctgcc agctgttgaa 12120 ttttgacctt cttaagcttg cgggagacgt cgagtccaac cctgggccca tgggtgctcg 12180 tgcttcagtg ctgtccggtg gcgagctgga caagtgggag aagatccgtc tgcgtcccgg 12240 tggcaagaag cagtacaagc tgaagcacat cgtgtgggct tcccgcgagc tggaacgttt 12300 cgctgtgaac cccggcctgc tggaaacctc cgagggttgc cgtcagatcc tgggccagct 12360 gcagccctcc ctgcagaccg gttccgagga actgcgttcc ctgtacaaca ctatcgctgt 12420 gctgtactgc gtgcaccagc gtatcgacgt gaaggacacc aaggaagctc tggacaagat 12480 cgaggaagaa cagaacaagt ccaagaagaa ggcccagcag gctgctgctg acaccggcaa 12540 caactcccag gtgtcccaga actaccccat cgtgcagaac ctgcagggcc agatggtgca 12600 ccaggctatc tccccccgta ccctgaacgc ttgggtcaag gtggtggaag agaaggcttt 12660 cagccccgaa gtgatcccca tgttctccgc tctgtccgag ggtgctaccc cccaggacct 12720 gaacaccatg ctgaacaccg tgggtggtca ccaggctgct atgcagatgc tgaaggaaac 12780 catcaacgaa gaggctgctg agtgggaccg tctgcacccc gtgcacgctg gtcctatcgc 12840 tcccggacag atgcgcgagc cccgtggttc cgacatcgct ggaaccacct ccaccctgca 12900 agagcagatc ggctggatga cccacaaccc ccccatcccc gtgggcgaga tctacaagcg 12960 ttggatcatc ctgggcctga acaagatcgt gcgtatgtac tcccccacct ccatcctgga 13020 catccgtcag ggtcccaagg aacccttccg tgactacgtg gaccgtttct acaagaccct 13080 gcgtgccgag caggcttccc aagaggtcaa gaactggatg accgagactc tgctggtgca 13140 gaacgctaac cccgactgca agaccatcct gaaggctctg ggtcccggtg ctaccctgga 13200 agagatgatg accgcttgcc agggtgtcgg tggtcccggt cacaaggctc gtgtgctggc 13260 tgaggctatg tcccaagtga ccaaccccgc taccatcatg atccagaagg gcaacttccg 13320 taaccagcgc aagaccgtga agtgcttcaa ctgcggcaag gaaggccaca tcgctaagaa 13380 ctgccgtgct ccccgcaaga agggctgctg gaagtgcgga aaggaaggac accagatgaa 13440 ggactgcacc gagcgtcagg ctaacttcct gggcaagatc tggccctccc acaagggtcg 13500 tcccggcaac ttcctgcagt cccgtcccga gcccaccgct cccccagagg aatccttccg 13560 tttcggcgag gaaaccacca ccccatccca gaagcaagag cccatcgaca aggaactgta 13620 ccccctggct tccctgcgct ccctgttcgg ttccgaccca tcctcccagc agctgttgaa 13680 ttttgacctt cttaagcttg cgggagacgt cgtcgagtcc aaccctgggc ccatggaatc 13740 ccgtggtcgt cgttgccccg agatgatctc cgtgctgggt cccatctccg gtcacgtcct 13800 gaaggctgtg ttctcccgtg gcgacacccc cgtgctgccc cacgaaactc gtctgctgca 13860 gaccggtatc cacgtgcgtg tgtcccagcc ctccctgatc ctggtgtccc agtacacccc 13920 cgactccacc ccttgccacc gcggagacaa ccagctgcag gtccagcaca cctacttcac 13980 cggttccgag gtcgagaacg tgtccgtgaa cgtgcacaac cccaccggtc gttccatctg 14040 cccctcccaa gagcccatgt ccatctacgt gtacgctctg cccctgaaga tgctgaacat 14100 cccctccatc aacgtgcacc actacccctc cgctgctgag cgcaagcacc gtcacctccc 14160 cgtggctgac gctgtgatcc acgcttccgg caagcagatg tggcaggctc gtctgaccgt 14220 gtccggcctg gcttggaccc gtcagcagaa ccagtggaag gaacccgacg tgtactacac 14280 ctccgctttc gtgttcccca ccaaggacgt ggccctgcgt cacgtcgtgt gcgctcacga 14340 actcgtgtgc tccatggaaa acacccgtgc taccaagatg caagtgatcg gcgaccagta 14400 cgtgaaggtg tacctggaat ccttctgcga ggacgtgccc tccggcaagc tgttcatgca 14460 cgtgaccctg ggttccgacg tggaagagga cctgaccatg acccgtaacc cccagccctt 14520 catgcgtccc cacgagcgta acggtttcac cgtgctgtgc cccaagaaca tgatcatcaa 14580 gcccggcaag atctcccaca tcatgctgga cgtggccttc acctcccacg agcacttcgg 14640 cctgctgtgc cctaagtcca tccccggcct gtccatctcc ggcaacctgc tgatgaacgg 14700 ccagcagatc ttcctggaag tgcaggctat ccgtgaaacc gtcgagctgc gtcagtacga 14760 ccctgtggct gctctgttct tcttcgacat cgacctgctg ctgcagcgtg gtccccagta 14820 ctccgagcac cccaccttca ccagccagta ccgtatccag ggcaagctgg aataccgtca 14880 cacctgggac cgtcacgacg agggtgctgc tcagggcgac gacgacgtgt ggacctccgg 14940 ttccgactcc gacgaggaac tggtcaccac cgagcgcaag accccccgtg tgaccggtgg 15000 tggtgctatg gctggtgctt ccacctccgc tggtcgcaag cgcaagtccg cttcctccgc 15060 taccgcttgc accgctggtg tcatgacccg tggtcgcctg aaggctgagt ccaccgtggc 15120 tcccgaagag gacactgacg aggactccga caacgagatc cacaaccccg ctgtgttcac 15180 ctggcccccc tggcaggctg gtatcctggc tcgtaacctg gtgcccatgg tggctaccgt 15240 gcagggccag aacctgaagt accaagagtt cttctgggac gccaacgaca tctaccgtat 15300 cttcgctgag ctggaaggcg tgtggcagcc cgctgctcag cccaagcgtc gtcgtcaccg 15360 tcaggacgct ctgcctggtc cctgtatcgc ttccaccccc aagaagcacc gcggctaaaa 15420 gcttgtcgag aagtactaga ggatcataat cagccatacc acatttgtag aggttttact 15480 tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt 15540 tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa 15600 tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa 15660 tgtatcttat catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca 15720 aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta tcataacccc 15780 taggagatcc gaaccagata agtgaaatct agttccaaac tattttgtca tttttaattt 15840 tcgtattagc ttacgacgct acacccagtt cccatctatt ttgtcactct tccctaaata 15900 atccttaaaa actccatttc cacccctccc agttcccaac tattttgtcc gcccaca 15957 <210> 33 <211> 15978 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 33 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttag cgagcgtcca cagcctgggg accgtaacgg gagtgagcgg 2400 gcaggttcac acgggtctgc ttcagctcag ggggcaggcc agcgtagtac ttgtccaggt 2460 gacgcagcag gggggggtcc agctggtgac gcaggcagaa ttccttcaca gcgttgtaca 2520 ggccgtagaa cagggtgata ccctcgggag cagcagcggt ggacacgggc agacgcacag 2580 cacggttggt acgggtagcc tcgttacgga tagccaccac cacgttgaac agggaggggg 2640 gcaccagctc gaaacccagc acgtgttcgg tgaagatgga acgaccgtag gacagacgag 2700 tcaggtcgta accacggcac aggtcgtcca cgcaagtgta cacagcgggg gaaccgtcgc 2760 cgcactcgga gtaaccgcgc atcacggtca tccaacgggg agcggtgtcg gaggacagca 2820 gggtcagcag agcacgcagc tggtcggggt tgttgtacag cagggccagg gtgtccagga 2880 aagcgtcgtc cagcagcacg gagttagcag cctcgggggt cacgggacgg taacggatca 2940 gctgggacag gggaccgtcc ctacgggtca cgttgaccag gggacgcagc caggactcgt 3000 acttgtcgcc ctggaacacc tctcccagca ggcaacgacg ggtcagctcg gggcactcag 3060 cgggcacctt ctcagccacg gtgggagcca cggacacggt agcggaggac acgatgggca 3120 gcagcaggca gcaccacagc agagccacgg gaccggggga gaaggagaaa ccgcagtcgg 3180 gacgacggca catggtggct cgagatcccg ggtgatcaag tcttcgtcga gtgattgtaa 3240 ataaaatgta atttacagta tagtatttta attaatatac aaatgatttg ataataattc 3300 ttatttaact ataatatatt gtgttgggtt gaattaaagg tccgtatact agtatcgatt 3360 cgcgacctac tccggaatat taatagatca tggagataat taaaatgata accatctcgc 3420 aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat 3480 tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccatga actccaagga 3540 cctgaccccc ttcctgacca ccctgtggct gctgctggac cactcccgtg tgcctcgtgt 3600 gcgtgctgag gaatgctgcg aagtgatcaa cgtgaaccac ccccccgagc gctgctacga 3660 cttcaagatg tgcaacctgt tcaccgtggc tctgcgttgc cccgacggcg aagtgtgcta 3720 ctcccccgaa aagaccgctg agatccgtgg tatcgtgacc accatgaccc actccctgac 3780 ccgtcaagtg atccacaaca agctgaccag ctgcaactac aaccccctgt acctcgaggc 3840 tgacggtcgt atccgttgcg gcaaggtgtc cgacaaggct cagtacctgc tgggtgctgc 3900 tggttccgtg ccctaccgtt ggatcaacct cgagtacgac aagatcaccc gtatcgtggg 3960 cctggaccag tacctcgagt ccgtgaagaa gcacaagcgt ctggacgtgt gccgtgctaa 4020 gatgggttac atgctgcagt aaaagcttgt cgagaagtac tagaggatca taatcagcca 4080 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 4140 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 4200 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4260 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 4320 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 4380 gctttgttta actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga 4440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 4500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 4560 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 4620 tgtgtgggct accccctgcc tggcttcccc ctggttcacc ctgaccgcta accagaaccc 4680 ctccccaccc tggtccaagc tgacctaccc caagccccac gacgctgcta ccttctactg 4740 ccccttcctg tacccatccc cacctcgttc cccatcccag ttctccggtt tccagcgtgt 4800 gtccaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 4860 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 4920 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 4980 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 5040 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctgga 5100 atcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 5160 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaagtcga 5220 caagcttgtc gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt 5280 acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat 5340 tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 5400 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 5460 caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta 5520 acaaagcccg aaaggaagct gagttggctg ctgggtgcct aatgagtgag ctaactcaca 5580 ttaattgccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 5640 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 5700 ggattattca taccgtccca ccatcgggcg cggatccgcc accggatccg ccaccatgcg 5760 tctgtgccgt gtgtggctgt ccgtgtgcct gtgcgctgtg gtgctgggac agtgccagcg 5820 tgaaaccgct gagaagaacg actactaccg tgtgccccac tactgggacg cttgctcccg 5880 tgctctgccc gaccagaccc gttacaagta cgtcgagcag ctggtggacc tgaccctgaa 5940 ctaccactac gacgcttccc acggcctgga caacttcgac gtgctgaagc gtatcaacgt 6000 gaccgaggtg tccctgctga tctccgactt ccgtcgtcag aaccgtcgtg gtggcaccaa 6060 caagcgtacc accttcaacg ctgctggttc cctggctccc cacgctcgtt ccttggagtt 6120 ctccgtgcgt ctgttcgcca actaataaaa gcttgtcgag aagtactaga ggatcataat 6180 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 6240 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 6300 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 6360 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 6420 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 6480 ccaccgctga gcaataacta tcataacccc cggaatatta atagatcatg gagataatta 6540 aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca gttttgtaat 6600 aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc gcggatcccg 6660 gtccgaagcg cgcggaattc aaaggcctac cgtcgacgcc accatggaat cccgtatctg 6720 gtgcctggtc gtgtgcgtga acctgtgcat cgtgtgcctg ggtgctgctg tgtcctcctc 6780 ctccacccgt ggcacctccg ctacccactc ccaccactcc tcccacacca cctccgccgc 6840 tcactcccgt tccggttccg tgtcccagcg tgtgacctcc tcccagaccg tgtcccacgg 6900 tgtcaacgag actatctaca acaccaccct gaagtacggc gacgtcgtgg gtgtcaacac 6960 caccaagtac ccctaccgtg tgtgctccat ggctcagggc accgacctga tccgtttcga 7020 gcgtaacatc gtgtgcacct ccatgaagcc catcaacgag gacctggacg agggtatcat 7080 ggtggtgtac aagcgcaaca tcgtggctca caccttcaag gtccgcgtgt accagaaggt 7140 gctgaccttc cgtcgttcct acgcttacat ccacaccact tacctgctgg gttccaacac 7200 cgagtacgtg gcccctccca tgtgggagat ccaccacatc aactcccact cccagtgcta 7260 ctcctcttac tcccgtgtga tcgctggcac cgtgttcgtg gcttaccacc gtgactccta 7320 cgagaacaag accatgcagc tgatgcccga cgactactcc aacacccact ccacccgtta 7380 cgtgaccgtg aaggaccagt ggcactcccg tggttccacc tggctgtacc gtgaaacctg 7440 caacctgaac tgcatggtca ccatcaccac cgctcgttcc aagtaccctt accacttctt 7500 cgctacctcc accggcgacg tggtggacat ctcccccttc tacaacggta ctaaccgtaa 7560 cgcttcctac ttcggcgaga acgctgacaa gttcttcatc ttccccaact acaccatcgt 7620 gtccgacttc ggtcgtccca actccgctct ggaaacccac cgtctggtgg ctttcttgga 7680 gcgtgctgac tccgtgatct cctgggacat ccaggacgag aagaacgtga cctgccagct 7740 gaccttctgg gaggcttccg agcgtaccat ccgttccgag gctgaggact cctaccactt 7800 ctccagcgct aagatgaccg ctaccttcct gtccaagaaa caagaggtca acatgtccga 7860 ctccgccctg gactgcgtgc gtgacgaggc tatcaacaag ctgcagcaga tcttcaacac 7920 ctcctacaac cagacctacg agaagtacgg aaacgtgtcc gtgttcgaga ctaccggtgg 7980 cctggtggtg ttctggcagg gtatcaagca gaagtccctg gtcgagctgg aacgtctggc 8040 taaccgttcc tccctgaacc tgacccacaa ccgtaccaag cgttccaccg acggcaacaa 8100 cgctactcac ctgtccaaca tggaatccgt gcacaacctg gtgtacgctc agctgcagtt 8160 cacctacgac accctgcgcg gttacatcaa ccgtgctctg gctcagatcg ctgaggcttg 8220 gtgcgtggac cagcgtcgta ccctggaagt gttcaaggaa ctgtccaaga tcaacccctc 8280 cgctatcctg tccgccatct acaacaagcc tatcgctgct cgtttcatgg gcgacgtgct 8340 gggcctggct tcctgcgtga ccatcaacca gacttccgtg aaggtgctgc gtgacatgaa 8400 cgtgaaggaa tcccccggtc gttgctactc ccgtcccgtg gtcatcttca acttcgctaa 8460 ctcctcctac gtgcagtacg gccagctggg cgaggacaac gagatcctgc tgggcaacca 8520 ccgtaccgag gaatgccagc tgccctccct gaagatcttc atcgctggca actccgctta 8580 cgaatacgtg gactacctgt tcaagcgcat gatcgacctg tcctccatct ctaccgtgga 8640 ctccatgatc gctctggaca tcgaccccct ggaaaacacc gacttccgtg tgctggaact 8700 gtactcccag aaggaactgc gttccatcaa cgtgttcgac ctggaagaga tcatgcgcga 8760 gttcaactcc tacaagcagc gtgttaagta cgtcgaggac aaggtggtgg accccctgcc 8820 cccctacctg aagggactgg acgacctgat gtccggcctg ggagctgccg gcaaggctgt 8880 gggtgtcgct atcggtgctg tgggtggtgc tgtggcttcc gtggtcgagg gtgtcgccac 8940 cttcctgaag aaccccttcg gtgctttcac catcatcctg gtggctatcg ctgtggtcat 9000 catcatctac ctgatctaca cccgtcagcg tcgtctgtgc atgcagcccc tgcagaacct 9060 gttcccctac ctggtgtccg ctgacggtac taccgtgacc tccggcaaca ccaaggacac 9120 ctccctgcag gctcccccat cctacgagga atccgtctac aactccggtc gcaagggtcc 9180 cggtccccct tcctccgacg cttctaccgc tgctccccca tacaccaacg agcaggctta 9240 ccagatgctg ctggctctcg tgcgtctgga cgctgagcag cgtgcacagc agaacggcac 9300 cgactccctg gacggccaga ccggaaccca ggacaagggc cagaagccca acctgctgga 9360 ccgtctgcgt caccgcaaga acggttaccg tcacctgaag gactccgacg aggaagagaa 9420 cgtctaaggc gcgccaagct tgtcgagaag tactagagat cataatcagc cataccacat 9480 ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata 9540 aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa 9600 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 9660 tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa 9720 gatccggctg ctaacaaagc ccgaaaggaa gctgggaata ttaatagatc atggagataa 9780 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 9840 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 9900 cgccaccatg cgtcccggcc tgccctccta cctgatcgtg ctggctgtgt gcctgctgtc 9960 ccacctcctg tcctcccgtt acggtgctga ggctatctcc gagcccctgg acaaggcttt 10020 ccacctcctg ctgaacacct acggtcgtcc tatccgtttc ctgcgcgaga acaccaccca 10080 gtgcacctac aactcctccc tgcgcaactc caccgtcgtc cgcgagaacg ctatctcctt 10140 caacttcttc cagtcctaca accagtacta cgtgttccac atgccccgtt gcctgttcgc 10200 tggtcccctg gctgagcagt tcctgaacca ggtggacctg accgagactc tcgagcgtta 10260 ccagcagcgt ctgaacactt acgctctggt gtccaaggac ctggcttcct accgttcctt 10320 cagccagcag ctgaaggctc aggactccct gggcgagcag cccaccactg tgcctccccc 10380 tatcgacctg tccatccccc acgtgtggat gcccccccag accactcctc acggctggac 10440 cgagtcccac accacctccg gactgcaccg tccccacttc aaccagacct gcatcctgtt 10500 cgacggtcac gacctgctgt tctccaccgt gaccccctgc ctgcaccagg gcttctacct 10560 catcgacgag ctgcgttacg tgaagatcac cctgaccgag gatttcttcg tggtcaccgt 10620 gtccatcgac gacgacaccc ccatgctgct gatcttcggt cacctccccc gtgtgctgtt 10680 caaggctccc taccagcgtg acaacttcat cctgcgtcag accgagaagc acgagctgct 10740 ggtgctggtc aagaaggacc agctgaaccg tcactcttac ctgaaggacc ccgacttcct 10800 ggacgctgct ctggacttca actacctgga cctgtccgct ctgctgagga actccttcca 10860 ccgttacgct gtggacgtgc tgaagtccgg tcgttgccag atgctggacc gtcgtaccgt 10920 cgagatggct ttcgcttacg ccctggctct gttcgctgct gctcgtcaag aagaggctgg 10980 cgctcaggtg tccgtgcccc gtgctctgga ccgtcaggct gctctgctgc agatccaaga 11040 gttcatgatc acttgcctgt cccagacccc ccctcgtacc accctgctgc tgtaccccac 11100 cgctgtggac ctggctaagc gtgctctgtg gacccccaac cagatcaccg acatcacctc 11160 cctcgtgcgt ctggtgtaca tcctgtccaa gcagaaccag cagcacctga tcccccagtg 11220 ggctctgcgt cagatcgctg acttcgctct gaagctgcac aagacccacc tggcttcatt 11280 cctcagcgct ttcgctcgcc aagagctgta cctgatgggt tccctggtgc actccatgct 11340 ggtgcacacc accgagcgtc gcgagatctt catcgtggaa accggcctgt gctccctggc 11400 cgagctgtcc cacttcaccc agctgctggc tcacccccac cacgagtacc tgtccgacct 11460 gtacaccccc tgctcctctt ccggtcgtcg tgaccactcc ctggaacgtc tgacccgtct 11520 gttccccgac gctaccgtgc ctaccaccgt gcctgctgct ctgtccatcc tgtctaccat 11580 gcagccctcc accctggaaa ccttccccga cctgttctgc ctgcctctgg gcgagtcctt 11640 ctccgctctg accgtgtccg agcacgtgtc ctacgtggtc accaaccagt acctgatcaa 11700 gggcatctcc taccccgtgt ccaccaccgt cgtgggccag tccctgatca tcacccagac 11760 cgactcccag accaagtgcg agctgacccg taacatgcac accactcact ccatcaccgc 11820 tgctctgaac atctccctcg agaactgcgc tttctgccag tccgctctgt tggagtacga 11880 cgacactcag ggtgtcatca acatcatgta catgcacgac tccgacgacg tgctgttcgc 11940 tctggacccc tacaacgagg tggtggtgtc ctccccccgt acccactacc tgatgctgct 12000 gaagaacggc accgtgctgg aagtgaccga cgtggtggtg gacgctaccg accgtctgct 12060 gatgatgtcc gtgtacgctc tgtccgctat catcggcatc tacctgctgt accgtatgct 12120 gaagacctgc cagctgttga attttgacct tcttaagctt gcgggagacg tcgagtccaa 12180 ccctgggccc atgggtgctc gtgcttcagt gctgtccggt ggcgagctgg acaagtggga 12240 gaagatccgt ctgcgtcccg gtggcaagaa gcagtacaag ctgaagcaca tcgtgtgggc 12300 ttcccgcgag ctggaacgtt tcgctgtgaa ccccggcctg ctggaaacct ccgagggttg 12360 ccgtcagatc ctgggccagc tgcagccctc cctgcagacc ggttccgagg aactgcgttc 12420 cctgtacaac actatcgctg tgctgtactg cgtgcaccag cgtatcgacg tgaaggacac 12480 caaggaagct ctggacaaga tcgaggaaga acagaacaag tccaagaaga aggcccagca 12540 ggctgctgct gacaccggca acaactccca ggtgtcccag aactacccca tcgtgcagaa 12600 cctgcagggc cagatggtgc accaggctat ctccccccgt accctgaacg cttgggtcaa 12660 ggtggtggaa gagaaggctt tcagccccga agtgatcccc atgttctccg ctctgtccga 12720 gggtgctacc ccccaggacc tgaacaccat gctgaacacc gtgggtggtc accaggctgc 12780 tatgcagatg ctgaaggaaa ccatcaacga agaggctgct gagtgggacc gtctgcaccc 12840 cgtgcacgct ggtcctatcg ctcccggaca gatgcgcgag ccccgtggtt ccgacatcgc 12900 tggaaccacc tccaccctgc aagagcagat cggctggatg acccacaacc cccccatccc 12960 cgtgggcgag atctacaagc gttggatcat cctgggcctg aacaagatcg tgcgtatgta 13020 ctcccccacc tccatcctgg acatccgtca gggtcccaag gaacccttcc gtgactacgt 13080 ggaccgtttc tacaagaccc tgcgtgccga gcaggcttcc caagaggtca agaactggat 13140 gaccgagact ctgctggtgc agaacgctaa ccccgactgc aagaccatcc tgaaggctct 13200 gggtcccggt gctaccctgg aagagatgat gaccgcttgc cagggtgtcg gtggtcccgg 13260 tcacaaggct cgtgtgctgg ctgaggctat gtcccaagtg accaaccccg ctaccatcat 13320 gatccagaag ggcaacttcc gtaaccagcg caagaccgtg aagtgcttca actgcggcaa 13380 ggaaggccac atcgctaaga actgccgtgc tccccgcaag aagggctgct ggaagtgcgg 13440 aaaggaagga caccagatga aggactgcac cgagcgtcag gctaacttcc tgggcaagat 13500 ctggccctcc cacaagggtc gtcccggcaa cttcctgcag tcccgtcccg agcccaccgc 13560 tcccccagag gaatccttcc gtttcggcga ggaaaccacc accccatccc agaagcaaga 13620 gcccatcgac aaggaactgt accccctggc ttccctgcgc tccctgttcg gttccgaccc 13680 atcctcccag cagctgttga attttgacct tcttaagctt gcgggagacg tcgtcgagtc 13740 caaccctggg cccatggaat cccgtggtcg tcgttgcccc gagatgatct ccgtgctggg 13800 tcccatctcc ggtcacgtcc tgaaggctgt gttctcccgt ggcgacaccc ccgtgctgcc 13860 ccacgaaact cgtctgctgc agaccggtat ccacgtgcgt gtgtcccagc cctccctgat 13920 cctggtgtcc cagtacaccc ccgactccac cccttgccac cgcggagaca accagctgca 13980 ggtccagcac acctacttca ccggttccga ggtcgagaac gtgtccgtga acgtgcacaa 14040 ccccaccggt cgttccatct gcccctccca agagcccatg tccatctacg tgtacgctct 14100 gcccctgaag atgctgaaca tcccctccat caacgtgcac cactacccct ccgctgctga 14160 gcgcaagcac cgtcacctcc ccgtggctga cgctgtgatc cacgcttccg gcaagcagat 14220 gtggcaggct cgtctgaccg tgtccggcct ggcttggacc cgtcagcaga accagtggaa 14280 ggaacccgac gtgtactaca cctccgcttt cgtgttcccc accaaggacg tggccctgcg 14340 tcacgtcgtg tgcgctcacg aactcgtgtg ctccatggaa aacacccgtg ctaccaagat 14400 gcaagtgatc ggcgaccagt acgtgaaggt gtacctggaa tccttctgcg aggacgtgcc 14460 ctccggcaag ctgttcatgc acgtgaccct gggttccgac gtggaagagg acctgaccat 14520 gacccgtaac ccccagccct tcatgcgtcc ccacgagcgt aacggtttca ccgtgctgtg 14580 ccccaagaac atgatcatca agcccggcaa gatctcccac atcatgctgg acgtggcctt 14640 cacctcccac gagcacttcg gcctgctgtg ccctaagtcc atccccggcc tgtccatctc 14700 cggcaacctg ctgatgaacg gccagcagat cttcctggaa gtgcaggcta tccgtgaaac 14760 cgtcgagctg cgtcagtacg accctgtggc tgctctgttc ttcttcgaca tcgacctgct 14820 gctgcagcgt ggtccccagt actccgagca ccccaccttc accagccagt accgtatcca 14880 gggcaagctg gaataccgtc acacctggga ccgtcacgac gagggtgctg ctcagggcga 14940 cgacgacgtg tggacctccg gttccgactc cgacgaggaa ctggtcacca ccgagcgcaa 15000 gaccccccgt gtgaccggtg gtggtgctat ggctggtgct tccacctccg ctggtcgcaa 15060 gcgcaagtcc gcttcctccg ctaccgcttg caccgctggt gtcatgaccc gtggtcgcct 15120 gaaggctgag tccaccgtgg ctcccgaaga ggacactgac gaggactccg acaacgagat 15180 ccacaacccc gctgtgttca cctggccccc ctggcaggct ggtatcctgg ctcgtaacct 15240 ggtgcccatg gtggctaccg tgcagggcca gaacctgaag taccaagagt tcttctggga 15300 cgccaacgac atctaccgta tcttcgctga gctggaaggc gtgtggcagc ccgctgctca 15360 gcccaagcgt cgtcgtcacc gtcaggacgc tctgcctggt ccctgtatcg cttccacccc 15420 caagaagcac cgcggctaaa agcttgtcga gaagtactag aggatcataa tcagccatac 15480 cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa 15540 acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa 15600 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 15660 tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac tgcttgagcc 15720 tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct gccaccgctg 15780 agcaataact atcataaccc ctaggagatc cgaaccagat aagtgaaatc tagttccaaa 15840 ctattttgtc atttttaatt ttcgtattag cttacgacgc tacacccagt tcccatctat 15900 tttgtcactc ttccctaaat aatccttaaa aactccattt ccacccctcc cagttcccaa 15960 ctattttgtc cgcccaca 15978 <210> 34 <211> 6940 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 34 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatggg 2700 tgctcgtgct tcagtgctgt ccggtggcga gctggacaag tgggagaaga tccgtctgcg 2760 tcccggtggc aagaagcagt acaagctgaa gcacatcgtg tgggcttccc gcgagctgga 2820 acgtttcgct gtgaaccccg gcctgctgga aacctccgag ggttgccgtc agatcctggg 2880 ccagctgcag ccctccctgc agaccggttc cgaggaactg cgttccctgt acaacactat 2940 cgctgtgctg tactgcgtgc accagcgtat cgacgtgaag gacaccaagg aagctctgga 3000 caagatcgag gaagaacaga acaagtccaa gaagaaggcc cagcaggctg ctgctgacac 3060 cggcaacaac tcccaggtgt cccagaacta ccccatcgtg cagaacctgc agggccagat 3120 ggtgcaccag gctatctccc cccgtaccct gaacgcttgg gtcaaggtgg tggaagagaa 3180 ggctttcagc cccgaagtga tccccatgtt ctccgctctg tccgagggtg ctacccccca 3240 ggacctgaac accatgctga acaccgtggg tggtcaccag gctgctatgc agatgctgaa 3300 ggaaaccatc aacgaagagg ctgctgagtg ggaccgtctg caccccgtgc acgctggtcc 3360 tatcgctccc ggacagatgc gcgagccccg tggttccgac atcgctggaa ccacctccac 3420 cctgcaagag cagatcggct ggatgaccca caaccccccc atccccgtgg gcgagatcta 3480 caagcgttgg atcatcctgg gcctgaacaa gatcgtgcgt atgtactccc ccacctccat 3540 cctggacatc cgtcagggtc ccaaggaacc cttccgtgac tacgtggacc gtttctacaa 3600 gaccctgcgt gccgagcagg cttcccaaga ggtcaagaac tggatgaccg agactctgct 3660 ggtgcagaac gctaaccccg actgcaagac catcctgaag gctctgggtc ccggtgctac 3720 cctggaagag atgatgaccg cttgccaggg tgtcggtggt cccggtcaca aggctcgtgt 3780 gctggctgag gctatgtccc aagtgaccaa ccccgctacc atcatgatcc agaagggcaa 3840 cttccgtaac cagcgcaaga ccgtgaagtg cttcaactgc ggcaaggaag gccacatcgc 3900 taagaactgc cgtgctcccc gcaagaaggg ctgctggaag tgcggaaagg aaggacacca 3960 gatgaaggac tgcaccgagc gtcaggctaa cttcctgggc aagatctggc cctcccacaa 4020 gggtcgtccc ggcaacttcc tgcagtcccg tcccgagccc accgctcccc cagaggaatc 4080 cttccgtttc ggcgaggaaa ccaccacccc atcccagaag caagagccca tcgacaagga 4140 actgtacccc ctggcttccc tgcgctccct gttcggttcc gacccatcct cccagtaagg 4200 cgccaagctt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 4260 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 4320 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 4380 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 4440 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 4500 ctaacaaagc ccgaaaggaa gctgggaata ttaatagatc atggagataa ttaaaatgat 4560 aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa 4620 cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc ccggtccgaa 4680 gcgcgcggaa ttcaaaggcc tacgtcgacg ccaccatgga atcccgtggt cgtcgttgcc 4740 ccgagatgat ctccgtgctg ggtcccatct ccggtcacgt cctgaaggct gtgttctccc 4800 gtggcgacac ccccgtgctg ccccacgaaa ctcgtctgct gcagaccggt atccacgtgc 4860 gtgtgtccca gccctccctg atcctggtgt cccagtacac ccccgactcc accccttgcc 4920 accgcggaga caaccagctg caggtccagc acacctactt caccggttcc gaggtcgaga 4980 acgtgtccgt gaacgtgcac aaccccaccg gtcgttccat ctgcccctcc caagagccca 5040 tgtccatcta cgtgtacgct ctgcccctga agatgctgaa catcccctcc atcaacgtgc 5100 accactaccc ctccgctgct gagcgcaagc accgtcacct ccccgtggct gacgctgtga 5160 tccacgcttc cggcaagcag atgtggcagg ctcgtctgac cgtgtccggc ctggcttgga 5220 cccgtcagca gaaccagtgg aaggaacccg acgtgtacta cacctccgct ttcgtgttcc 5280 ccaccaagga cgtggccctg cgtcacgtcg tgtgcgctca cgaactcgtg tgctccatgg 5340 aaaacacccg tgctaccaag atgcaagtga tcggcgacca gtacgtgaag gtgtacctgg 5400 aatccttctg cgaggacgtg ccctccggca agctgttcat gcacgtgacc ctgggttccg 5460 acgtggaaga ggacctgacc atgacccgta acccccagcc cttcatgcgt ccccacgagc 5520 gtaacggttt caccgtgctg tgccccaaga acatgatcat caagcccggc aagatctccc 5580 acatcatgct ggacgtggcc ttcacctccc acgagcactt cggcctgctg tgccctaagt 5640 ccatccccgg cctgtccatc tccggcaacc tgctgatgaa cggccagcag atcttcctgg 5700 aagtgcaggc tatccgtgaa accgtcgagc tgcgtcagta cgaccctgtg gctgctctgt 5760 tcttcttcga catcgacctg ctgctgcagc gtggtcccca gtactccgag caccccacct 5820 tcaccagcca gtaccgtatc cagggcaagc tggaataccg tcacacctgg gaccgtcacg 5880 acgagggtgc tgctcagggc gacgacgacg tgtggacctc cggttccgac tccgacgagg 5940 aactggtcac caccgagcgc aagacccccc gtgtgaccgg tggtggtgct atggctggtg 6000 cttccacctc cgctggtcgc aagcgcaagt ccgcttcctc cgctaccgct tgcaccgctg 6060 gtgtcatgac ccgtggtcgc ctgaaggctg agtccaccgt ggctcccgaa gaggacactg 6120 acgaggactc cgacaacgag atccacaacc ccgctgtgtt cacctggccc ccctggcagg 6180 ctggtatcct ggctcgtaac ctggtgccca tggtggctac cgtgcagggc cagaacctga 6240 agtaccaaga gttcttctgg gacgccaacg acatctaccg tatcttcgct gagctggaag 6300 gcgtgtggca gcccgctgct cagcccaagc gtcgtcgtca ccgtcaggac gctctgcctg 6360 gtccctgtat cgcttccacc cccaagaagc accgcggcta aaagcttgtc gagaagtact 6420 agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc 6480 cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta 6540 ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat 6600 ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct 6660 ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg aaaggaagct 6720 gagttggctg ctgccaccgc tgagcaataa ctatcataac ccctaggaga tccgaaccag 6780 ataagtgaaa tctagttcca aactattttg tcatttttaa ttttcgtatt agcttacgac 6840 gctacaccca gttcccatct attttgtcac tcttccctaa ataatcctta aaaactccat 6900 ttccacccct cccagttccc aactattttg tccgcccaca 6940 <210> 35 <211> 17177 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 35 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgccca ccgctgagca ataactatca taacccccgg aatattaata gatcatggag 7200 ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt 7260 ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg 7320 gatccgccac catggctgct atggaagcta acatcttctg caccttcgac cacaagctgt 7380 ctatcgctga cgtgggcaag ctgaccaagc tggtggctgc tgtggtgccc atcccccagc 7440 gtctgcacct gatcaagcac taccagctgg gcctgcacca gttcgtggac cacacccgtg 7500 gttacgtgcg tctgcgtggc ctgctgcgta acatgaccct gaccctgatg cgtcgtgtcg 7560 agggcaacca gatcctgctg cacgtgccca cccacggcct gctgtacacc gtgctgaaca 7620 ccggtcccgt gacctgggag aagggcgacg ctctgtgcgt gctgcccccc ctgttccacg 7680 gtcccctggc tcgtgaaaac ctgttgaccc tgggccagtg ggagctggtg ctgccctgga 7740 tcgtgcccat gcccctggct ctggaaatca accagcgcct gctgatcatg ggcctgttct 7800 ccctggaccg ttcctacgaa gaagtgaagg ctgctgtcca gcagctgcag accatcacct 7860 tccgtgacgc taccttcacc atccccgacc ccgtgatcga ccagcacctc ctgatcgaca 7920 tgaagaccgc ttgcctgtcc atgtccatgg tggctaacct ggcttccgag ctgaccatga 7980 cctacgtccg caagctggct ttggaggact cttccatgct gctggtcaag tgccaagagc 8040 tgctgatgcg tctggaccgc gagcgttccg tgggcgagcc tcgtactccc gctcgtcctc 8100 agcacgtgtc ccccgacgac gagatcgctc gtctgtccgc tctgttcgtg atgctgcgtc 8160 agctggacga cctgatccgc gagcaggtcg tgttcaccgt gtgcgacgtg agcccagaca 8220 acaagtccgc tacctgcatc ttcaagggct aaggcgcgcc aagcttgtcg agaagtacta 8280 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 8340 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 8400 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 8460 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 8520 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 8580 agttggctgc tgccaccgct gagcaataac tatcataacc cccggaatat taatagatca 8640 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 8700 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 8760 gcgcggatcc cggtccgaag cgcgcggaat tcaaaggcct gccaccatgg aaatgaacaa 8820 ggtgctgcat caggatctgg tgcaggctac ccgtcgtatc ctgaagctgg gcccctccga 8880 gctgcgtgtg accgacgctg gcctgatctg caagaacccc aactactccg tgtgcgacgc 8940 tatgctcaag accgacaccg tgtactgcgt cgagtacctg ctgtcctact gggagtcccg 9000 taccgaccac gtgccctgct tcatcttcaa gaacaccggt tgcgctgtgt ccctgtgctg 9060 cttcgtgcgt gctcccgtga agctggtgtc ccctgctcgt cacgtgggcg agttcaacgt 9120 gctgaaggtc aacgagtccc tgatcgtgac cctgaaggac atcgaggaaa tcaagccctc 9180 cgcttacggt gtcctgacta agtgcgtcgt ccgcaagtcc aactccgctt ccgtgttcaa 9240 catcgagctg atcgctttcg gtcccgagaa cgagggcgag tacgagaacc tgctgcgcga 9300 gctgtacgct aagaaggctg cttccacctc cctggctgtg cgtaaccacg tgaccgtgtc 9360 ctcccactcc ggttccggtc cctccctgtg gcgtgctcgt atgtccgctg ctctgacccg 9420 taccgctggc aagcgctcct ccaggactgc tagccctcca ccaccacctc ctcgtcaccc 9480 tagctgctct cccactatgg tggctgctgg tggagctgct gctggtccta gacctccccc 9540 tcctcctatg gctgctggat cctggcgtct gtgccgttgc gaggcttgca tgggccgttg 9600 cggttgcgct tccgagggcg acgctgacga ggaagaggaa gagttgctgg ctctggctgg 9660 cgagggcaag gctgctgctg ccgctgccgg tcaagacgtc ggtggttccg ctcgtcgtcc 9720 cctcgaggaa cacgtgtccc gtcgtcgtgg tgtctccacc caccaccgtc accccccttc 9780 cccaccttgc gctccctccc tggaacgtac cggttaccgt tgggctcctt cctcctggtg 9840 gcgcgctcgt tctggtcctt cccgtcccca gtccggtccc tggctgcctg ctcgtttcgc 9900 taccctgggt cccctggtcc tggctctgct gttggtgctg gccctgctgt ggcgtggtca 9960 cggtcaatcc cccagcccca cccgttccgc tcaccgtgac taaaagcttg tcgagaagta 10020 ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 10080 cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 10140 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 10200 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 10260 ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag 10320 ctgagttggc tgctgtggct agctttgttt aactttaaga aggagataca tctagaaata 10380 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 10440 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 10500 cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcaaaggcc tacgtcgacg 10560 ccaccatgtc caacaccgct cccggtccca ccgtggctaa caagcgtgac gagaagcacc 10620 gtcacgtggt caacgtggtg ctcgagctgc ccaccgagat ctccgaggct acccaccccg 10680 tgctggctac catgctgtcc aagtacaccc gtatgtcctc cctgttcaac gacaagtgcg 10740 ctttcaagct ggacctgctg cgtatggtgg ctgtgtcccg tacccgtcgc taaaagcttg 10800 tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 10860 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 10920 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 10980 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 11040 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 11100 cgaaaggaag ctgagttggc tgctgggtgc ctaatgagtg agctaactca cattaattgc 11160 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 11220 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 11280 cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt cgccaccatg 11340 gacgctcgtg ctgtggctaa gcgtccccgt gaccccgctg acgaggacaa cgagctggtc 11400 accgctctga aggctaagcg tgaagtgaac accatctccg tgcgttacct gtaccacgct 11460 gaccaccagg ctctgaccgc tcgtttcttc gtgcccgagg gcctggtcga gttcgaggct 11520 cagcccggtg ctctgctgat ccgtatggaa accggttgcg actccccccg tcacctgtac 11580 atctccctgt acctgctggg tatccgtgct tccaacgtgt ccgcttccac ccgttgcctg 11640 ctcgagtccg tgtacaccgc ttccgctgct cgtgctgctc tgcagtggct ggacctgggt 11700 ccccacctcc tgcaccgtcg tctggaaacc ctgggttgcg tcaagaccgt gtccctgggt 11760 atcacctccc tgctgacctg cgtgatgcgc ggctacctgt acaacaccct caagaccgag 11820 gtgttcgctc tgatgatccc caaggacatg tacctgacct gggaggaaac ccgcggtcgt 11880 ctgcagtacg tgtacctgat catcgtgtac gactacgacg gtcccgagac tcgtcccggt 11940 atctacgtgc tgacctcctc tatcgctcac tggcagaccc tggtggacgt ggcccgtgga 12000 aagttcgctc gtgaacgctg ctccttcgtg aaccgtcgta tcacccgtcc ccgtcagatc 12060 cccctgtgca ccggtgtcat ccaaaagctg ggctggtgcc tggctgacga catccacacc 12120 tcattcctcg tgcacaagga actgaagctg tccgtcgtgc gtctggacaa cttctccgtc 12180 gagctgggcg acttccgcga gttcgtgcag ctgttgaatt ttgaccttct taagcttgcg 12240 ggagacgtcg agtccaaccc tgggcccatg gaatcccgtg gtcgtcgttg ccccgagatg 12300 atctccgtgc tgggtcccat ctccggtcac gtcctgaagg ctgtgttctc ccgtggcgac 12360 acccccgtgc tgccccacga aactcgtctg ctgcagaccg gtatccacgt gcgtgtgtcc 12420 cagccctccc tgatcctggt gtcccagtac acccccgact ccaccccttg ccaccgcgga 12480 gacaaccagc tgcaggtcca gcacacctac ttcaccggtt ccgaggtcga gaacgtgtcc 12540 gtgaacgtgc acaaccccac cggtcgttcc atctgcccct cccaagagcc catgtccatc 12600 tacgtgtacg ctctgcccct gaagatgctg aacatcccct ccatcaacgt gcaccactac 12660 ccctccgctg ctgagcgcaa gcaccgtcac ctccccgtgg ctgacgctgt gatccacgct 12720 tccggcaagc agatgtggca ggctcgtctg accgtgtccg gcctggcttg gacccgtcag 12780 cagaaccagt ggaaggaacc cgacgtgtac tacacctccg ctttcgtgtt ccccaccaag 12840 gacgtggccc tgcgtcacgt cgtgtgcgct cacgaactcg tgtgctccat ggaaaacacc 12900 cgtgctacca agatgcaagt gatcggcgac cagtacgtga aggtgtacct ggaatccttc 12960 tgcgaggacg tgccctccgg caagctgttc atgcacgtga ccctgggttc cgacgtggaa 13020 gaggacctga ccatgacccg taacccccag cccttcatgc gtccccacga gcgtaacggt 13080 ttcaccgtgc tgtgccccaa gaacatgatc atcaagcccg gcaagatctc ccacatcatg 13140 ctggacgtgg ccttcacctc ccacgagcac ttcggcctgc tgtgccctaa gtccatcccc 13200 ggcctgtcca tctccggcaa cctgctgatg aacggccagc agatcttcct ggaagtgcag 13260 gctatccgtg aaaccgtcga gctgcgtcag tacgaccctg tggctgctct gttcttcttc 13320 gacatcgacc tgctgctgca gcgtggtccc cagtactccg agcaccccac cttcaccagc 13380 cagtaccgta tccagggcaa gctggaatac cgtcacacct gggaccgtca cgacgagggt 13440 gctgctcagg gcgacgacga cgtgtggacc tccggttccg actccgacga ggaactggtc 13500 accaccgagc gcaagacccc ccgtgtgacc ggtggtggtg ctatggctgg tgcttccacc 13560 tccgctggtc gcaagcgcaa gtccgcttcc tccgctaccg cttgcaccgc tggtgtcatg 13620 acccgtggtc gcctgaaggc tgagtccacc gtggctcccg aagaggacac tgacgaggac 13680 tccgacaacg agatccacaa ccccgctgtg ttcacctggc ccccctggca ggctggtatc 13740 ctggctcgta acctggtgcc catggtggct accgtgcagg gccagaacct gaagtaccaa 13800 gagttcttct gggacgccaa cgacatctac cgtatcttcg ctgagctgga aggcgtgtgg 13860 cagcccgctg ctcagcccaa gcgtcgtcgt caccgtcagg acgctctgcc tggtccctgt 13920 atcgcttcca cccccaagaa gcaccgcggc taaaagcttg tcgagaagta ctagaggatc 13980 ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc 14040 cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct 14100 tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 14160 ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga 14220 tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc 14280 tgctgtggct agctttgttt aactttaaga aggagataca tctagacctg caggccggaa 14340 tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt 14400 actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc 14460 gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcgccac catgaccatg 14520 gacgagcagc agccccaggc tgtgaccccc gtgtacgtgg gcggtttcct ggctcgttac 14580 gaccagtccc ccgacgaggc tgagctgctg ctgccacgtg acgtggtcga acactggctg 14640 cacgctcagg gccagggaca gccttccctg tccgtggctc tgcccctgaa catcaaccac 14700 gacgacaccg ctgtcgtggg tcacgtggcc gctatgcagt ccgtgcgtga cggcctgttc 14760 tgcctgggtt gcgtgacctc cccccgtttc ctggaaatcg tgcgtcgtgc ttccgagaag 14820 tccgagctgg tgtcccgtgg tcccgtgtcc ccactgcagc ccgacaaggt ggtcgagttc 14880 ctgtccggtt cctacgctgg cctgtccctg tcatcccgtc gttgcgacga cgtcgaggct 14940 gctacctccc tgagcggctc cgagactacc cccttcaagc acgtggccct gtgctccgtg 15000 ggtcgtaggc gtggaaccct ggctgtgtac ggtcgtgacc ccgagtgggt cacccagcgt 15060 ttccccgacc tgaccgctgc tgaccgtgac ggactgcgtg ctcagtggca gcgttgcggt 15120 tccaccgctg tggacgcttc cggcgacccc ttccgttccg actcctacgg cctgctgggc 15180 aactccgtgg acgctctgta catccgcgag cgtctgccca agctgcgtta cgacaagcag 15240 ctcgtgggtg tcaccgagcg cgagtcctac gtgaaggctt ccgtgtcccc cgaggctgct 15300 tgcgacatca aggctgcttc cgctgagcgt tctggcgaca gccgctccca ggctgctact 15360 cctgctgctg gtgctcgtgt gccctccagc tccccatccc cacctgtcga gcctccctcc 15420 cccgtgcaac ctcctgctct gcctgcttcc ccctccgtgc tgcctgctga gtccagcccc 15480 tccctgtcac cctctgagcc tgctgaggct gcctccatgt cccaccctct gagcgctgct 15540 gtgactgctg ctaccgctcc ccctggtgct actgtggctg gtgcttcccc cgctgtgcct 15600 tccctggctt ggcctcacga cggtgtctac ctgcccaagg acgctttctt ctccctgctg 15660 ggcgcttccc gttccgctgc tcccgtgatg taccccggtg ctgtggctgc tccccccagc 15720 gcttcacctg ctcctctgcc cctgccctcc taccccgctt cctacggtgc tcccgtcgtg 15780 ggttacgacc agctggctgc tcgtcacttc gctgactacg tggaccccca ctaccccggc 15840 tggggtcgtc gttacgagcc cgctccttcc ctgcacccat cctaccctgt gccccctcct 15900 ccatcacccg cttactaccg tcgtcgtgac tcccccggtg gcatggacga gcctccatct 15960 ggatgggagc gttacgacgg ttcccaccgt ggccagtccc aaaagcagca ccgtcacggt 16020 ggttccggtg gtcacaacaa gcgtcgcaag gaagccgctg ctgcatcctc cagctccgac 16080 gaggacctga gcttccccgg cgaggctgaa cacggtcgtg ctcgcaagcg tctgaagtcc 16140 cacgtgaact ccgacggagg tagcggaggc cacgctggtt ccaaccagca gcagcaacag 16200 cgctacgacg agctgcgtga cgctatccac gagctgaagc gtgacctgtt cgctgctcgc 16260 cagtcctcca ccctgctgtc tgctgctctg ccagctgccg cttcttcctc ccctaccacc 16320 accaccgtgt gcacccctac tggcgagctg acctctggtg gtggcgagac tcccaccgct 16380 ctgctgtccg gtggtgctaa ggtggccgag cgtgctcagg ctggtgtcgt gaacgcttcc 16440 tgccgtctgg ctaccgcttc cggttccgag gctgccaccg ctggtccctc taccgctggt 16500 tcctcatcct gcccagcttc cgtggtgctg gctgccgctg ctgctcaagc cgccgctgct 16560 tcacagtccc ccccaaagga tatggtggac ctgaaccgtc gtatcttcgt ggctgctctg 16620 aacaagctcg agtaataaaa gcttgtcgag aagtactaga ggatcataat cagccatacc 16680 acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa 16740 cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa 16800 taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt 16860 ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact gcttgagcct 16920 agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ccaccgctga 16980 gcaataacta tcataacccc taggagatcc gaaccagata agtgaaatct agttccaaac 17040 tattttgtca tttttaattt tcgtattagc ttacgacgct acacccagtt cccatctatt 17100 ttgtcactct tccctaaata atccttaaaa actccatttc cacccctccc agttcccaac 17160 tattttgtcc gcccaca 17177 <210> 36 <211> 21120 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 36 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgccaccgct gagcaataac tatcataacc cccggaatat taatagatca tggagataat 7200 taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta 7260 ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc 7320 gccaccatgg ctgctatgga agctaacatc ttctgcacct tcgaccacaa gctgtctatc 7380 gctgacgtgg gcaagctgac caagctggtg gctgctgtgg tgcccatccc ccagcgtctg 7440 cacctgatca agcactacca gctgggcctg caccagttcg tggaccacac ccgtggttac 7500 gtgcgtctgc gtggcctgct gcgtaacatg accctgaccc tgatgcgtcg tgtcgagggc 7560 aaccagatcc tgctgcacgt gcccacccac ggcctgctgt acaccgtgct gaacaccggt 7620 cccgtgacct gggagaaggg cgacgctctg tgcgtgctgc cccccctgtt ccacggtccc 7680 ctggctcgtg aaaacctgtt gaccctgggc cagtgggagc tggtgctgcc ctggatcgtg 7740 cccatgcccc tggctctgga aatcaaccag cgcctgctga tcatgggcct gttctccctg 7800 gaccgttcct acgaagaagt gaaggctgct gtccagcagc tgcagaccat caccttccgt 7860 gacgctacct tcaccatccc cgaccccgtg atcgaccagc acctcctgat cgacatgaag 7920 accgcttgcc tgtccatgtc catggtggct aacctggctt ccgagctgac catgacctac 7980 gtccgcaagc tggctttgga ggactcttcc atgctgctgg tcaagtgcca agagctgctg 8040 atgcgtctgg accgcgagcg ttccgtgggc gagcctcgta ctcccgctcg tcctcagcac 8100 gtgtcccccg acgacgagat cgctcgtctg tccgctctgt tcgtgatgct gcgtcagctg 8160 gacgacctga tccgcgagca ggtcgtgttc accgtgtgcg acgtgagccc agacaacaag 8220 tccgctacct gcatcttcaa gggctaaggc gcgccaagct tgtcgagaag tactagagga 8280 tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc 8340 tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag 8400 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 8460 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct 8520 gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg 8580 gctgctgcca ccgctgagca ataactatca taacccctag gggcctctaa acgggtcttg 8640 aggggttttt tgctgaaagg aggaactata tccggatctg aacaggaggg acagctgata 8700 gaaacagaag ccactggagc acctcaaaaa caccatcata cactaaatca gtaagttggc 8760 agcatcaccc gacgcacttt gcgccgaata aatacctgtg acggaagatc acttcgcaga 8820 ataaataaat cctggtgtcc ctgttgatac cgggaagccc tgggccaact tttggcgaaa 8880 atgagacgtt gatcggcacg taagaggttc caactttcac cataatgaaa taagatcact 8940 accgggcgta ttttttgagt tatcgagatt ttcaggagct aaggaagcta aaatggagaa 9000 aaaaatcact ggatatacca ccgttgatat atcccaatgg catcgtaaag aacattttga 9060 ggcatttcag tcagttgctc aatgtaccta taaccagacc gttcagctgg atattacggc 9120 ctttttaaag accgtaaaga aaaataagca caagttttat ccggccttta ttcacattct 9180 tgcccgcctg atgaatgctc atccggaatt ccgtatggca atgaaagacg gtgagctggt 9240 gatatgggat agtgttcacc cttgttacac cgttttccat gagcaaactg aaacgttttc 9300 atcgctctgg agtgaatacc acgacgattt ccggcagttt ctacacatat attcgcaaga 9360 tgtggcgtgt tacggtgaaa acctggccta tttccctaaa gggtttattg agaatatgtt 9420 tttcgtctca gccaatccct gggtgagttt caccagtttt gatttaaacg tggccaatat 9480 ggacaacttc ttcgcccccg ttttcaccat gggcaaatat tatacgcaag gcgacaaggt 9540 gctgatgccg ctggcgattc aggttcatca tgccgtttgt gatggcttcc atgtcggcag 9600 aatgcttaat gaattacaac agtactgcga tgagtggcag ggcggggcgt aattttttta 9660 aggcagttat tggtgccctt aaacgcctgg ttgctacgcc tgaataagtg ataataagcg 9720 gatgaatggc agaaattcga aagcaaattc gacccggtcg tcggttcagg gcagggtcgt 9780 taaatagccg cttatgtcta ttgctggttt accggtttat tgactaccgg aagcagtgtg 9840 accgtgtgct tctcaaatgc ctgaggccag tttgctcagg ctctccccgt ggaggtaata 9900 attgacgata tgatcattta ttctgcctcc cagctgacat tcatccgggg tcagcaccgt 9960 ttctgcggac tggctttcta cgtgttccgc ttcctttagc agcccttgcg ccctgagtgc 10020 ttgcggcagc gtgaagctaa ttctgtcagc cgttaagtgt tcctgtgtca ctcaaaattg 10080 ctttgagagg ctctaagggc ttctcagtgc gttacatccc tggcttgttg tccacaaccg 10140 ttaaacctta aaagctttaa aagccttata tattcttttt tttcttataa aacttaaaac 10200 cttagaggct atttaagttg ctgatttata ttaattttat tgttcaaaca tgagagctta 10260 gtacgtgaaa catgagagct tagtacgtta gccatgagag cttagtacgt tagccatgag 10320 ggtttagttc gttaaacatg agagcttagt acgttaaaca tgagagctta gtacgtgaaa 10380 catgagagct tagtacgtac tatcaacagg ttgaactgct gatcaacaga tcctctacgc 10440 ggccgcggta ccataacttc gtatagcata cattatacga agttatctgg tttaaacgta 10500 cccgtagtgg ctatggcagg gcttgccgcc ccgacgttgg ctgcgagccc tgggccttca 10560 cccgaacttg ggggttgggg tggggaaaag gaagaaacgc gggcgtattg gtcccaatgg 10620 ggtctcggtg gggtatcgac agagtgccag ccctgggacc gaaccccgcg tttatgaaca 10680 aacgacccaa cacccgtgcg ttttattctg tctttttatt gccgtcatag cgcgggttcc 10740 ttccggtatt gtctccttcc gtgtttcagt tagcctcccc catctcccgg taccgcatgc 10800 tatgcatcag ctgctagctt agcgagcgtc cacagcctgg ggaccgtaac gggagtgagc 10860 gggcaggttc acacgggtct gcttcagctc agggggcagg ccagcgtagt acttgtccag 10920 gtgacgcagc aggggggggt ccagctggtg acgcaggcag aattccttca cagcgttgta 10980 caggccgtag aacagggtga taccctcggg agcagcagcg gtggacacgg gcagacgcac 11040 agcacggttg gtacgggtag cctcgttacg gatagccacc accacgttga acagggaggg 11100 gggcaccagc tcgaaaccca gcacgtgttc ggtgaagatg gaacgaccgt aggacagacg 11160 agtcaggtcg taaccacggc acaggtcgtc cacgcaagtg tacacagcgg gggaaccgtc 11220 gccgcactcg gagtaaccgc gcatcacggt catccaacgg ggagcggtgt cggaggacag 11280 cagggtcagc agagcacgca gctggtcggg gttgttgtac agcagggcca gggtgtccag 11340 gaaagcgtcg tccagcagca cggagttagc agcctcgggg gtcacgggac ggtaacggat 11400 cagctgggac aggggaccgt ccctacgggt cacgttgacc aggggacgca gccaggactc 11460 gtacttgtcg ccctggaaca cctctcccag caggcaacga cgggtcagct cggggcactc 11520 agcgggcacc ttctcagcca cggtgggagc cacggacacg gtagcggagg acacgatggg 11580 cagcagcagg cagcaccaca gcagagccac gggaccgggg gagaaggaga aaccgcagtc 11640 gggacgacgg cacatggtgg ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 11700 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 11760 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 11820 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 11880 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 11940 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat gtcccccaag 12000 aacctgaccc ccttcctgac cgctctgtgg ctgctgctgg gccactcccg tgtgcctcgt 12060 gtgcgtgctg aggaatgctg cgagttcatc aacgtgaacc acccccccga gcgctgctac 12120 gacttcaaga tgtgcaaccg tttcaccgtg gctctgcgtt gccccgacgg cgaagtgtgc 12180 tactcccccg aaaagaccgc tgagatccgt ggtatcgtga ccaccatgac ccactccctg 12240 acccgtcagg tggtgcacaa caagctgacc tcttgcaact acaaccccct gtacctcgag 12300 gctgacggtc gtatccgttg cggcaaggtc aacgacaagg ctcagtacct gctgggtgct 12360 gctggttccg tgccctaccg ttggatcaac ctcgagtacg acaagatcac ccgtatcgtg 12420 ggcctggacc agtacctcga gtccgtgaag aagcacaagc gtctggacgt gtgccgtgct 12480 aagatgggtt acatgctgca gtaaaagctt gtcgagaagt actagaggat cataatcagc 12540 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 12600 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 12660 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 12720 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 12780 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgtggc 12840 tagctttgtt taactttaag aaggagatac atctagaccg gaatattaat agatcatgga 12900 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 12960 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 13020 ggatccgcca ccatgctgcg tctgctgctg cgtcaccact tccactgcct gctgctgtgc 13080 gctgtgtggg ctaccccctg cctggcttcc ccttggtcca ccctgaccgc taaccagaac 13140 ccctccccac cctggtccaa gctgacctac tccaagcccc acgacgctgc taccttctac 13200 tgccccttcc tgtacccatc cccccctcgt tccccactgc agttctccgg tttccagcgt 13260 gtgctgaccg gtcccgagtg ccgtaacgag actctgtacc tgctgtacaa ccgcgagggc 13320 cagaccctgg tcgagaggtc ctccacctgg gtcaagaagg tcatctggta cttgtccggt 13380 cgtaaccaga ccatcctgca gcgtatgccc cgtaccgctt ccaagccctc cgacggcaac 13440 gtgcagatct ccgtcgagga cgctaagatc ttcggtgctc acatggtgcc caagcagacc 13500 aagctgctgc gtttcgtggt caacgacggc acccgttacc agatgtgcgt gatgaagctc 13560 gagtcctggg ctcacgtgtt ccgtgactac tccgtgtcct tccaagtgcg cctgaccttc 13620 accgaggcta acaaccagac ctacaccttc tgcacccacc ccaacctgat cgtgtaaaag 13680 cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga ggttttactt 13740 gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt 13800 gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat 13860 ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat 13920 gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg ctgctaacaa 13980 agcccgaaag gaagctgagt tggctgctgg gtgcctaatg agtgagctaa ctcacattaa 14040 ttgcccggaa tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa 14100 taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat 14160 tattcatacc gtcccaccat cgggcgcgga tccgccacca tgcgtctgtg ccgtgtgtgg 14220 ctgtccgtgt gcctgtgcgc tgtggtgctg ggccagtgcc agcgtgaaac cgctgagaag 14280 aacgactact accgtgtgcc ccactactgg gacgcttgct cccgtgctct gcccgaccag 14340 acccgttaca agtacgtcga gcagctggtg gacctgaccc tgaactacca ctacgacgct 14400 tcccacggcc tggacaactt cgacgtgctg aagcgtatca acgtgaccga ggtgtccctg 14460 ctgatctccg acttccgtcg tcagaaccgt cgtggtggca ccaacaagcg taccaccttc 14520 aacgctgctg gttccctggc tccccacgct cgttccctcg agttctccgt gcgtctgttc 14580 gctaactaaa agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta 14640 gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 14700 aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat 14760 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 14820 aaactcatca atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc 14880 ggctgctaac aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact 14940 atcataaccc ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca 15000 aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt 15060 ccggattatt cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt 15120 caaaggccta ccgtcgacgc caccatggaa tcccgtatct ggtgcctggt cgtgtgcgtg 15180 aacctgtgca tcgtgtgcct gggtgctgct gtgtcctcct cctccacccg tggcacctcc 15240 gctacccact cccaccactc ctcccacacc acctccgccg ctcactcccg ttccggttcc 15300 gtgtcccagc gtgtgacctc ctcccagacc gtgtcccacg gtgtcaacga gactatctac 15360 aacaccaccc tgaagtacgg cgacgtcgtg ggtgtcaaca ccaccaagta cccctaccgt 15420 gtgtgctcca tggctcaggg caccgacctg atccgtttcg agcgtaacat cgtgtgcacc 15480 tccatgaagc ccatcaacga ggacctggac gagggtatca tggtggtgta caagcgcaac 15540 atcgtggctc acaccttcaa ggtccgcgtg taccagaagg tgctgacctt ccgtcgttcc 15600 tacgcttaca tccacaccac ttacctgctg ggttccaaca ccgagtacgt ggcccctccc 15660 atgtgggaga tccaccacat caactcccac tcccagtgct actcctctta ctcccgtgtg 15720 atcgctggca ccgtgttcgt ggcttaccac cgtgactcct acgagaacaa gaccatgcag 15780 ctgatgcccg acgactactc caacacccac tccacccgtt acgtgaccgt gaaggaccag 15840 tggcactccc gtggttccac ctggctgtac cgtgaaacct gcaacctgaa ctgcatggtc 15900 accatcacca ccgctcgttc caagtaccct taccacttct tcgctacctc caccggcgac 15960 gtggtggaca tctccccctt ctacaacggt actaaccgta acgcttccta cttcggcgag 16020 aacgctgaca agttcttcat cttccccaac tacaccatcg tgtccgactt cggtcgtccc 16080 aactccgctc tggaaaccca ccgtctggtg gctttcttgg agcgtgctga ctccgtgatc 16140 tcctgggaca tccaggacga gaagaacgtg acctgccagc tgaccttctg ggaggcttcc 16200 gagcgtacca tccgttccga ggctgaggac tcctaccact tctccagcgc taagatgacc 16260 gctaccttcc tgtccaagaa acaagaggtc aacatgtccg actccgccct ggactgcgtg 16320 cgtgacgagg ctatcaacaa gctgcagcag atcttcaaca cctcctacaa ccagacctac 16380 gagaagtacg gaaacgtgtc cgtgttcgag actaccggtg gcctggtggt gttctggcag 16440 ggtatcaagc agaagtccct ggtcgagctg gaacgtctgg ctaaccgttc ctccctgaac 16500 ctgacccaca accgtaccaa gcgttccacc gacggcaaca acgctactca cctgtccaac 16560 atggaatccg tgcacaacct ggtgtacgct cagctgcagt tcacctacga caccctgcgc 16620 ggttacatca accgtgctct ggctcagatc gctgaggctt ggtgcgtgga ccagcgtcgt 16680 accctggaag tgttcaagga actgtccaag atcaacccct ccgctatcct gtccgccatc 16740 tacaacaagc ctatcgctgc tcgtttcatg ggcgacgtgc tgggcctggc ttcctgcgtg 16800 accatcaacc agacttccgt gaaggtgctg cgtgacatga acgtgaagga atcccccggt 16860 cgttgctact cccgtcccgt ggtcatcttc aacttcgcta actcctccta cgtgcagtac 16920 ggccagctgg gcgaggacaa cgagatcctg ctgggcaacc accgtaccga ggaatgccag 16980 ctgccctccc tgaagatctt catcgctggc aactccgctt acgaatacgt ggactacctg 17040 ttcaagcgca tgatcgacct gtcctccatc tctaccgtgg actccatgat cgctctggac 17100 atcgaccccc tggaaaacac cgacttccgt gtgctggaac tgtactccca gaaggaactg 17160 cgttccatca acgtgttcga cctggaagag atcatgcgcg agttcaactc ctacaagcag 17220 cgtgttaagt acgtcgagga caaggtggtg gaccccctgc ccccctacct gaagggactg 17280 gacgacctga tgtccggcct gggagctgcc ggcaaggctg tgggtgtcgc tatcggtgct 17340 gtgggtggtg ctgtggcttc cgtggtcgag ggtgtcgcca ccttcctgaa gaaccccttc 17400 ggtgctttca ccatcatcct ggtggctatc gctgtggtca tcatcatcta cctgatctac 17460 acccgtcagc gtcgtctgtg catgcagccc ctgcagaacc tgttccccta cctggtgtcc 17520 gctgacggta ctaccgtgac ctccggcaac accaaggaca cctccctgca ggctccccca 17580 tcctacgagg aatccgtcta caactccggt cgcaagggtc ccggtccccc ttcctccgac 17640 gcttctaccg ctgctccccc atacaccaac gagcaggctt accagatgct gctggctctc 17700 gtgcgtctgg acgctgagca gcgtgcacag cagaacggca ccgactccct ggacggccag 17760 accggaaccc aggacaaggg ccagaagccc aacctgctgg accgtctgcg tcaccgcaag 17820 aacggttacc gtcacctgaa ggactccgac gaggaagaga acgtctaagg cgcgccaagc 17880 ttgtcgagaa gtactagaga tcataatcag ccataccaca tttgtagagg ttttacttgc 17940 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 18000 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 18060 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 18120 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 18180 cccgaaagga agctgggaat attaatagat catggagata attaaaatga taaccatctc 18240 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 18300 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat gcgtcccggc 18360 ctgccctcct acctgatcgt gctggctgtg tgcctgctgt cccacctcct gtcctcccgt 18420 tacggtgctg aggctatctc cgagcccctg gacaaggctt tccacctcct gctgaacacc 18480 tacggtcgtc ctatccgttt cctgcgcgag aacaccaccc agtgcaccta caactcctcc 18540 ctgcgcaact ccaccgtcgt ccgcgagaac gctatctcct tcaacttctt ccagtcctac 18600 aaccagtact acgtgttcca catgccccgt tgcctgttcg ctggtcccct ggctgagcag 18660 ttcctgaacc aggtggacct gaccgagact ctcgagcgtt accagcagcg tctgaacact 18720 tacgctctgg tgtccaagga cctggcttcc taccgttcct tcagccagca gctgaaggct 18780 caggactccc tgggcgagca gcccaccact gtgcctcccc ctatcgacct gtccatcccc 18840 cacgtgtgga tgccccccca gaccactcct cacggctgga ccgagtccca caccacctcc 18900 ggactgcacc gtccccactt caaccagacc tgcatcctgt tcgacggtca cgacctgctg 18960 ttctccaccg tgaccccctg cctgcaccag ggcttctacc tcatcgacga gctgcgttac 19020 gtgaagatca ccctgaccga ggatttcttc gtggtcaccg tgtccatcga cgacgacacc 19080 cccatgctgc tgatcttcgg tcacctcccc cgtgtgctgt tcaaggctcc ctaccagcgt 19140 gacaacttca tcctgcgtca gaccgagaag cacgagctgc tggtgctggt caagaaggac 19200 cagctgaacc gtcactctta cctgaaggac cccgacttcc tggacgctgc tctggacttc 19260 aactacctgg acctgtccgc tctgctgagg aactccttcc accgttacgc tgtggacgtg 19320 ctgaagtccg gtcgttgcca gatgctggac cgtcgtaccg tcgagatggc tttcgcttac 19380 gccctggctc tgttcgctgc tgctcgtcaa gaagaggctg gcgctcaggt gtccgtgccc 19440 cgtgctctgg accgtcaggc tgctctgctg cagatccaag agttcatgat cacttgcctg 19500 tcccagaccc cccctcgtac caccctgctg ctgtacccca ccgctgtgga cctggctaag 19560 cgtgctctgt ggacccccaa ccagatcacc gacatcacct ccctcgtgcg tctggtgtac 19620 atcctgtcca agcagaacca gcagcacctg atcccccagt gggctctgcg tcagatcgct 19680 gacttcgctc tgaagctgca caagacccac ctggcttcat tcctcagcgc tttcgctcgc 19740 caagagctgt acctgatggg ttccctggtg cactccatgc tggtgcacac caccgagcgt 19800 cgcgagatct tcatcgtgga aaccggcctg tgctccctgg ccgagctgtc ccacttcacc 19860 cagctgctgg ctcaccccca ccacgagtac ctgtccgacc tgtacacccc ctgctcctct 19920 tccggtcgtc gtgaccactc cctggaacgt ctgacccgtc tgttccccga cgctaccgtg 19980 cctaccaccg tgcctgctgc tctgtccatc ctgtctacca tgcagccctc caccctggaa 20040 accttccccg acctgttctg cctgcctctg ggcgagtcct tctccgctct gaccgtgtcc 20100 gagcacgtgt cctacgtggt caccaaccag tacctgatca agggcatctc ctaccccgtg 20160 tccaccaccg tcgtgggcca gtccctgatc atcacccaga ccgactccca gaccaagtgc 20220 gagctgaccc gtaacatgca caccactcac tccatcaccg ctgctctgaa catctccctc 20280 gagaactgcg ctttctgcca gtccgctctg ttggagtacg acgacactca gggtgtcatc 20340 aacatcatgt acatgcacga ctccgacgac gtgctgttcg ctctggaccc ctacaacgag 20400 gtggtggtgt cctccccccg tacccactac ctgatgctgc tgaagaacgg caccgtgctg 20460 gaagtgaccg acgtggtggt ggacgctacc gaccgtctgc tgatgatgtc cgtgtacgct 20520 ctgtccgcta tcatcggcat ctacctgctg taccgtatgc tgaagacctg ctaaggcgcc 20580 aagctttgtc gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt 20640 acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat 20700 tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 20760 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 20820 caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta 20880 acaaagcccg aaaggaagct gagttggctg ctgccaccgc tgagcaataa ctatcataac 20940 ccctaggaga tccgaaccag ataagtgaaa tctagttcca aactattttg tcatttttaa 21000 ttttcgtatt agcttacgac gctacaccca gttcccatct attttgtcac tcttccctaa 21060 ataatcctta aaaactccat ttccacccct cccagttccc aactattttg tccgcccaca 21120 <210> 37 <211> 21120 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 37 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgccaccgct gagcaataac tatcataacc cccggaatat taatagatca tggagataat 7200 taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta 7260 ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc 7320 gccaccatgg ctgctatgga agctaacatc ttctgcacct tcgaccacaa gctgtctatc 7380 gctgacgtgg gcaagctgac caagctggtg gctgctgtgg tgcccatccc ccagcgtctg 7440 cacctgatca agcactacca gctgggcctg caccagttcg tggaccacac ccgtggttac 7500 gtgcgtctgc gtggcctgct gcgtaacatg accctgaccc tgatgcgtcg tgtcgagggc 7560 aaccagatcc tgctgcacgt gcccacccac ggcctgctgt acaccgtgct gaacaccggt 7620 cccgtgacct gggagaaggg cgacgctctg tgcgtgctgc cccccctgtt ccacggtccc 7680 ctggctcgtg aaaacctgtt gaccctgggc cagtgggagc tggtgctgcc ctggatcgtg 7740 cccatgcccc tggctctgga aatcaaccag cgcctgctga tcatgggcct gttctccctg 7800 gaccgttcct acgaagaagt gaaggctgct gtccagcagc tgcagaccat caccttccgt 7860 gacgctacct tcaccatccc cgaccccgtg atcgaccagc acctcctgat cgacatgaag 7920 accgcttgcc tgtccatgtc catggtggct aacctggctt ccgagctgac catgacctac 7980 gtccgcaagc tggctttgga ggactcttcc atgctgctgg tcaagtgcca agagctgctg 8040 atgcgtctgg accgcgagcg ttccgtgggc gagcctcgta ctcccgctcg tcctcagcac 8100 gtgtcccccg acgacgagat cgctcgtctg tccgctctgt tcgtgatgct gcgtcagctg 8160 gacgacctga tccgcgagca ggtcgtgttc accgtgtgcg acgtgagccc agacaacaag 8220 tccgctacct gcatcttcaa gggctaaggc gcgccaagct tgtcgagaag tactagagga 8280 tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc 8340 tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag 8400 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 8460 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct 8520 gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg 8580 gctgctgcca ccgctgagca ataactatca taacccctag gggcctctaa acgggtcttg 8640 aggggttttt tgctgaaagg aggaactata tccggatctg aacaggaggg acagctgata 8700 gaaacagaag ccactggagc acctcaaaaa caccatcata cactaaatca gtaagttggc 8760 agcatcaccc gacgcacttt gcgccgaata aatacctgtg acggaagatc acttcgcaga 8820 ataaataaat cctggtgtcc ctgttgatac cgggaagccc tgggccaact tttggcgaaa 8880 atgagacgtt gatcggcacg taagaggttc caactttcac cataatgaaa taagatcact 8940 accgggcgta ttttttgagt tatcgagatt ttcaggagct aaggaagcta aaatggagaa 9000 aaaaatcact ggatatacca ccgttgatat atcccaatgg catcgtaaag aacattttga 9060 ggcatttcag tcagttgctc aatgtaccta taaccagacc gttcagctgg atattacggc 9120 ctttttaaag accgtaaaga aaaataagca caagttttat ccggccttta ttcacattct 9180 tgcccgcctg atgaatgctc atccggaatt ccgtatggca atgaaagacg gtgagctggt 9240 gatatgggat agtgttcacc cttgttacac cgttttccat gagcaaactg aaacgttttc 9300 atcgctctgg agtgaatacc acgacgattt ccggcagttt ctacacatat attcgcaaga 9360 tgtggcgtgt tacggtgaaa acctggccta tttccctaaa gggtttattg agaatatgtt 9420 tttcgtctca gccaatccct gggtgagttt caccagtttt gatttaaacg tggccaatat 9480 ggacaacttc ttcgcccccg ttttcaccat gggcaaatat tatacgcaag gcgacaaggt 9540 gctgatgccg ctggcgattc aggttcatca tgccgtttgt gatggcttcc atgtcggcag 9600 aatgcttaat gaattacaac agtactgcga tgagtggcag ggcggggcgt aattttttta 9660 aggcagttat tggtgccctt aaacgcctgg ttgctacgcc tgaataagtg ataataagcg 9720 gatgaatggc agaaattcga aagcaaattc gacccggtcg tcggttcagg gcagggtcgt 9780 taaatagccg cttatgtcta ttgctggttt accggtttat tgactaccgg aagcagtgtg 9840 accgtgtgct tctcaaatgc ctgaggccag tttgctcagg ctctccccgt ggaggtaata 9900 attgacgata tgatcattta ttctgcctcc cagctgacat tcatccgggg tcagcaccgt 9960 ttctgcggac tggctttcta cgtgttccgc ttcctttagc agcccttgcg ccctgagtgc 10020 ttgcggcagc gtgaagctaa ttctgtcagc cgttaagtgt tcctgtgtca ctcaaaattg 10080 ctttgagagg ctctaagggc ttctcagtgc gttacatccc tggcttgttg tccacaaccg 10140 ttaaacctta aaagctttaa aagccttata tattcttttt tttcttataa aacttaaaac 10200 cttagaggct atttaagttg ctgatttata ttaattttat tgttcaaaca tgagagctta 10260 gtacgtgaaa catgagagct tagtacgtta gccatgagag cttagtacgt tagccatgag 10320 ggtttagttc gttaaacatg agagcttagt acgttaaaca tgagagctta gtacgtgaaa 10380 catgagagct tagtacgtac tatcaacagg ttgaactgct gatcaacaga tcctctacgc 10440 ggccgcggta ccataacttc gtatagcata cattatacga agttatctgg tttaaacgta 10500 cccgtagtgg ctatggcagg gcttgccgcc ccgacgttgg ctgcgagccc tgggccttca 10560 cccgaacttg ggggttgggg tggggaaaag gaagaaacgc gggcgtattg gtcccaatgg 10620 ggtctcggtg gggtatcgac agagtgccag ccctgggacc gaaccccgcg tttatgaaca 10680 aacgacccaa cacccgtgcg ttttattctg tctttttatt gccgtcatag cgcgggttcc 10740 ttccggtatt gtctccttcc gtgtttcagt tagcctcccc catctcccgg taccgcatgc 10800 tatgcatcag ctgctagctt agcgagcgtc cacagcctgg ggaccgtaac gggagtgagc 10860 gggcaggttc acacgggtct gcttcagctc agggggcagg ccagcgtagt acttgtccag 10920 gtgacgcagc aggggggggt ccagctggtg acgcaggcag aattccttca cagcgttgta 10980 caggccgtag aacagggtga taccctcggg agcagcagcg gtggacacgg gcagacgcac 11040 agcacggttg gtacgggtag cctcgttacg gatagccacc accacgttga acagggaggg 11100 gggcaccagc tcgaaaccca gcacgtgttc ggtgaagatg gaacgaccgt aggacagacg 11160 agtcaggtcg taaccacggc acaggtcgtc cacgcaagtg tacacagcgg gggaaccgtc 11220 gccgcactcg gagtaaccgc gcatcacggt catccaacgg ggagcggtgt cggaggacag 11280 cagggtcagc agagcacgca gctggtcggg gttgttgtac agcagggcca gggtgtccag 11340 gaaagcgtcg tccagcagca cggagttagc agcctcgggg gtcacgggac ggtaacggat 11400 cagctgggac aggggaccgt ccctacgggt cacgttgacc aggggacgca gccaggactc 11460 gtacttgtcg ccctggaaca cctctcccag caggcaacga cgggtcagct cggggcactc 11520 agcgggcacc ttctcagcca cggtgggagc cacggacacg gtagcggagg acacgatggg 11580 cagcagcagg cagcaccaca gcagagccac gggaccgggg gagaaggaga aaccgcagtc 11640 gggacgacgg cacatggtgg ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 11700 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 11760 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 11820 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 11880 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 11940 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat gaactccaag 12000 gacctgaccc ccttcctgac caccctgtgg ctgctgctgg accactcccg tgtgcctcgt 12060 gtgcgtgctg aggaatgctg cgaagtgatc aacgtgaacc acccccccga gcgctgctac 12120 gacttcaaga tgtgcaacct gttcaccgtg gctctgcgtt gccccgacgg cgaagtgtgc 12180 tactcccccg aaaagaccgc tgagatccgt ggtatcgtga ccaccatgac ccactccctg 12240 acccgtcaag tgatccacaa caagctgacc agctgcaact acaaccccct gtacctcgag 12300 gctgacggtc gtatccgttg cggcaaggtg tccgacaagg ctcagtacct gctgggtgct 12360 gctggttccg tgccctaccg ttggatcaac ctcgagtacg acaagatcac ccgtatcgtg 12420 ggcctggacc agtacctcga gtccgtgaag aagcacaagc gtctggacgt gtgccgtgct 12480 aagatgggtt acatgctgca gtaaaagctt gtcgagaagt actagaggat cataatcagc 12540 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 12600 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 12660 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 12720 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 12780 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgtggc 12840 tagctttgtt taactttaag aaggagatac atctagaccg gaatattaat agatcatgga 12900 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 12960 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 13020 ggatccgcca ccatgctgcg tctgctgctg cgtcaccact tccactgcct gctgctgtgc 13080 gctgtgtggg ctaccccctg cctggcttcc ccttggtcca ccctgaccgc taaccagaac 13140 ccctccccac cctggtccaa gctgacctac tccaagcccc acgacgctgc taccttctac 13200 tgccccttcc tgtacccatc cccccctcgt tccccactgc agttctccgg tttccagcgt 13260 gtgctgaccg gtcccgagtg ccgtaacgag actctgtacc tgctgtacaa ccgcgagggc 13320 cagaccctgg tcgagaggtc ctccacctgg gtcaagaagg tcatctggta cttgtccggt 13380 cgtaaccaga ccatcctgca gcgtatgccc cgtaccgctt ccaagccctc cgacggcaac 13440 gtgcagatct ccgtcgagga cgctaagatc ttcggtgctc acatggtgcc caagcagacc 13500 aagctgctgc gtttcgtggt caacgacggc acccgttacc agatgtgcgt gatgaagctc 13560 gagtcctggg ctcacgtgtt ccgtgactac tccgtgtcct tccaagtgcg cctgaccttc 13620 accgaggcta acaaccagac ctacaccttc tgcacccacc ccaacctgat cgtgtaaaag 13680 cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga ggttttactt 13740 gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt 13800 gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat 13860 ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat 13920 gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg ctgctaacaa 13980 agcccgaaag gaagctgagt tggctgctgg gtgcctaatg agtgagctaa ctcacattaa 14040 ttgcccggaa tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa 14100 taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat 14160 tattcatacc gtcccaccat cgggcgcgga tccgccacca tgcgtctgtg ccgtgtgtgg 14220 ctgtccgtgt gcctgtgcgc tgtggtgctg ggccagtgcc agcgtgaaac cgctgagaag 14280 aacgactact accgtgtgcc ccactactgg gacgcttgct cccgtgctct gcccgaccag 14340 acccgttaca agtacgtcga gcagctggtg gacctgaccc tgaactacca ctacgacgct 14400 tcccacggcc tggacaactt cgacgtgctg aagcgtatca acgtgaccga ggtgtccctg 14460 ctgatctccg acttccgtcg tcagaaccgt cgtggtggca ccaacaagcg taccaccttc 14520 aacgctgctg gttccctggc tccccacgct cgttccctcg agttctccgt gcgtctgttc 14580 gctaactaaa agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta 14640 gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 14700 aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat 14760 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 14820 aaactcatca atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc 14880 ggctgctaac aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact 14940 atcataaccc ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca 15000 aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt 15060 ccggattatt cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt 15120 caaaggccta ccgtcgacgc caccatggaa tcccgtatct ggtgcctggt cgtgtgcgtg 15180 aacctgtgca tcgtgtgcct gggtgctgct gtgtcctcct cctccacccg tggcacctcc 15240 gctacccact cccaccactc ctcccacacc acctccgccg ctcactcccg ttccggttcc 15300 gtgtcccagc gtgtgacctc ctcccagacc gtgtcccacg gtgtcaacga gactatctac 15360 aacaccaccc tgaagtacgg cgacgtcgtg ggtgtcaaca ccaccaagta cccctaccgt 15420 gtgtgctcca tggctcaggg caccgacctg atccgtttcg agcgtaacat cgtgtgcacc 15480 tccatgaagc ccatcaacga ggacctggac gagggtatca tggtggtgta caagcgcaac 15540 atcgtggctc acaccttcaa ggtccgcgtg taccagaagg tgctgacctt ccgtcgttcc 15600 tacgcttaca tccacaccac ttacctgctg ggttccaaca ccgagtacgt ggcccctccc 15660 atgtgggaga tccaccacat caactcccac tcccagtgct actcctctta ctcccgtgtg 15720 atcgctggca ccgtgttcgt ggcttaccac cgtgactcct acgagaacaa gaccatgcag 15780 ctgatgcccg acgactactc caacacccac tccacccgtt acgtgaccgt gaaggaccag 15840 tggcactccc gtggttccac ctggctgtac cgtgaaacct gcaacctgaa ctgcatggtc 15900 accatcacca ccgctcgttc caagtaccct taccacttct tcgctacctc caccggcgac 15960 gtggtggaca tctccccctt ctacaacggt actaaccgta acgcttccta cttcggcgag 16020 aacgctgaca agttcttcat cttccccaac tacaccatcg tgtccgactt cggtcgtccc 16080 aactccgctc tggaaaccca ccgtctggtg gctttcttgg agcgtgctga ctccgtgatc 16140 tcctgggaca tccaggacga gaagaacgtg acctgccagc tgaccttctg ggaggcttcc 16200 gagcgtacca tccgttccga ggctgaggac tcctaccact tctccagcgc taagatgacc 16260 gctaccttcc tgtccaagaa acaagaggtc aacatgtccg actccgccct ggactgcgtg 16320 cgtgacgagg ctatcaacaa gctgcagcag atcttcaaca cctcctacaa ccagacctac 16380 gagaagtacg gaaacgtgtc cgtgttcgag actaccggtg gcctggtggt gttctggcag 16440 ggtatcaagc agaagtccct ggtcgagctg gaacgtctgg ctaaccgttc ctccctgaac 16500 ctgacccaca accgtaccaa gcgttccacc gacggcaaca acgctactca cctgtccaac 16560 atggaatccg tgcacaacct ggtgtacgct cagctgcagt tcacctacga caccctgcgc 16620 ggttacatca accgtgctct ggctcagatc gctgaggctt ggtgcgtgga ccagcgtcgt 16680 accctggaag tgttcaagga actgtccaag atcaacccct ccgctatcct gtccgccatc 16740 tacaacaagc ctatcgctgc tcgtttcatg ggcgacgtgc tgggcctggc ttcctgcgtg 16800 accatcaacc agacttccgt gaaggtgctg cgtgacatga acgtgaagga atcccccggt 16860 cgttgctact cccgtcccgt ggtcatcttc aacttcgcta actcctccta cgtgcagtac 16920 ggccagctgg gcgaggacaa cgagatcctg ctgggcaacc accgtaccga ggaatgccag 16980 ctgccctccc tgaagatctt catcgctggc aactccgctt acgaatacgt ggactacctg 17040 ttcaagcgca tgatcgacct gtcctccatc tctaccgtgg actccatgat cgctctggac 17100 atcgaccccc tggaaaacac cgacttccgt gtgctggaac tgtactccca gaaggaactg 17160 cgttccatca acgtgttcga cctggaagag atcatgcgcg agttcaactc ctacaagcag 17220 cgtgttaagt acgtcgagga caaggtggtg gaccccctgc ccccctacct gaagggactg 17280 gacgacctga tgtccggcct gggagctgcc ggcaaggctg tgggtgtcgc tatcggtgct 17340 gtgggtggtg ctgtggcttc cgtggtcgag ggtgtcgcca ccttcctgaa gaaccccttc 17400 ggtgctttca ccatcatcct ggtggctatc gctgtggtca tcatcatcta cctgatctac 17460 acccgtcagc gtcgtctgtg catgcagccc ctgcagaacc tgttccccta cctggtgtcc 17520 gctgacggta ctaccgtgac ctccggcaac accaaggaca cctccctgca ggctccccca 17580 tcctacgagg aatccgtcta caactccggt cgcaagggtc ccggtccccc ttcctccgac 17640 gcttctaccg ctgctccccc atacaccaac gagcaggctt accagatgct gctggctctc 17700 gtgcgtctgg acgctgagca gcgtgcacag cagaacggca ccgactccct ggacggccag 17760 accggaaccc aggacaaggg ccagaagccc aacctgctgg accgtctgcg tcaccgcaag 17820 aacggttacc gtcacctgaa ggactccgac gaggaagaga acgtctaagg cgcgccaagc 17880 ttgtcgagaa gtactagaga tcataatcag ccataccaca tttgtagagg ttttacttgc 17940 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 18000 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 18060 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 18120 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 18180 cccgaaagga agctgggaat attaatagat catggagata attaaaatga taaccatctc 18240 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 18300 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat gcgtcccggc 18360 ctgccctcct acctgatcgt gctggctgtg tgcctgctgt cccacctcct gtcctcccgt 18420 tacggtgctg aggctatctc cgagcccctg gacaaggctt tccacctcct gctgaacacc 18480 tacggtcgtc ctatccgttt cctgcgcgag aacaccaccc agtgcaccta caactcctcc 18540 ctgcgcaact ccaccgtcgt ccgcgagaac gctatctcct tcaacttctt ccagtcctac 18600 aaccagtact acgtgttcca catgccccgt tgcctgttcg ctggtcccct ggctgagcag 18660 ttcctgaacc aggtggacct gaccgagact ctcgagcgtt accagcagcg tctgaacact 18720 tacgctctgg tgtccaagga cctggcttcc taccgttcct tcagccagca gctgaaggct 18780 caggactccc tgggcgagca gcccaccact gtgcctcccc ctatcgacct gtccatcccc 18840 cacgtgtgga tgccccccca gaccactcct cacggctgga ccgagtccca caccacctcc 18900 ggactgcacc gtccccactt caaccagacc tgcatcctgt tcgacggtca cgacctgctg 18960 ttctccaccg tgaccccctg cctgcaccag ggcttctacc tcatcgacga gctgcgttac 19020 gtgaagatca ccctgaccga ggatttcttc gtggtcaccg tgtccatcga cgacgacacc 19080 cccatgctgc tgatcttcgg tcacctcccc cgtgtgctgt tcaaggctcc ctaccagcgt 19140 gacaacttca tcctgcgtca gaccgagaag cacgagctgc tggtgctggt caagaaggac 19200 cagctgaacc gtcactctta cctgaaggac cccgacttcc tggacgctgc tctggacttc 19260 aactacctgg acctgtccgc tctgctgagg aactccttcc accgttacgc tgtggacgtg 19320 ctgaagtccg gtcgttgcca gatgctggac cgtcgtaccg tcgagatggc tttcgcttac 19380 gccctggctc tgttcgctgc tgctcgtcaa gaagaggctg gcgctcaggt gtccgtgccc 19440 cgtgctctgg accgtcaggc tgctctgctg cagatccaag agttcatgat cacttgcctg 19500 tcccagaccc cccctcgtac caccctgctg ctgtacccca ccgctgtgga cctggctaag 19560 cgtgctctgt ggacccccaa ccagatcacc gacatcacct ccctcgtgcg tctggtgtac 19620 atcctgtcca agcagaacca gcagcacctg atcccccagt gggctctgcg tcagatcgct 19680 gacttcgctc tgaagctgca caagacccac ctggcttcat tcctcagcgc tttcgctcgc 19740 caagagctgt acctgatggg ttccctggtg cactccatgc tggtgcacac caccgagcgt 19800 cgcgagatct tcatcgtgga aaccggcctg tgctccctgg ccgagctgtc ccacttcacc 19860 cagctgctgg ctcaccccca ccacgagtac ctgtccgacc tgtacacccc ctgctcctct 19920 tccggtcgtc gtgaccactc cctggaacgt ctgacccgtc tgttccccga cgctaccgtg 19980 cctaccaccg tgcctgctgc tctgtccatc ctgtctacca tgcagccctc caccctggaa 20040 accttccccg acctgttctg cctgcctctg ggcgagtcct tctccgctct gaccgtgtcc 20100 gagcacgtgt cctacgtggt caccaaccag tacctgatca agggcatctc ctaccccgtg 20160 tccaccaccg tcgtgggcca gtccctgatc atcacccaga ccgactccca gaccaagtgc 20220 gagctgaccc gtaacatgca caccactcac tccatcaccg ctgctctgaa catctccctc 20280 gagaactgcg ctttctgcca gtccgctctg ttggagtacg acgacactca gggtgtcatc 20340 aacatcatgt acatgcacga ctccgacgac gtgctgttcg ctctggaccc ctacaacgag 20400 gtggtggtgt cctccccccg tacccactac ctgatgctgc tgaagaacgg caccgtgctg 20460 gaagtgaccg acgtggtggt ggacgctacc gaccgtctgc tgatgatgtc cgtgtacgct 20520 ctgtccgcta tcatcggcat ctacctgctg taccgtatgc tgaagacctg ctaaggcgcc 20580 aagctttgtc gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt 20640 acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat 20700 tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 20760 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 20820 caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta 20880 acaaagcccg aaaggaagct gagttggctg ctgccaccgc tgagcaataa ctatcataac 20940 ccctaggaga tccgaaccag ataagtgaaa tctagttcca aactattttg tcatttttaa 21000 ttttcgtatt agcttacgac gctacaccca gttcccatct attttgtcac tcttccctaa 21060 ataatcctta aaaactccat ttccacccct cccagttccc aactattttg tccgcccaca 21120 <210> 38 <211> 21141 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 38 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgccaccgct gagcaataac tatcataacc cccggaatat taatagatca tggagataat 7200 taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta 7260 ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc 7320 gccaccatgg ctgctatgga agctaacatc ttctgcacct tcgaccacaa gctgtctatc 7380 gctgacgtgg gcaagctgac caagctggtg gctgctgtgg tgcccatccc ccagcgtctg 7440 cacctgatca agcactacca gctgggcctg caccagttcg tggaccacac ccgtggttac 7500 gtgcgtctgc gtggcctgct gcgtaacatg accctgaccc tgatgcgtcg tgtcgagggc 7560 aaccagatcc tgctgcacgt gcccacccac ggcctgctgt acaccgtgct gaacaccggt 7620 cccgtgacct gggagaaggg cgacgctctg tgcgtgctgc cccccctgtt ccacggtccc 7680 ctggctcgtg aaaacctgtt gaccctgggc cagtgggagc tggtgctgcc ctggatcgtg 7740 cccatgcccc tggctctgga aatcaaccag cgcctgctga tcatgggcct gttctccctg 7800 gaccgttcct acgaagaagt gaaggctgct gtccagcagc tgcagaccat caccttccgt 7860 gacgctacct tcaccatccc cgaccccgtg atcgaccagc acctcctgat cgacatgaag 7920 accgcttgcc tgtccatgtc catggtggct aacctggctt ccgagctgac catgacctac 7980 gtccgcaagc tggctttgga ggactcttcc atgctgctgg tcaagtgcca agagctgctg 8040 atgcgtctgg accgcgagcg ttccgtgggc gagcctcgta ctcccgctcg tcctcagcac 8100 gtgtcccccg acgacgagat cgctcgtctg tccgctctgt tcgtgatgct gcgtcagctg 8160 gacgacctga tccgcgagca ggtcgtgttc accgtgtgcg acgtgagccc agacaacaag 8220 tccgctacct gcatcttcaa gggctaaggc gcgccaagct tgtcgagaag tactagagga 8280 tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc 8340 tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag 8400 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 8460 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct 8520 gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg 8580 gctgctgcca ccgctgagca ataactatca taacccctag gggcctctaa acgggtcttg 8640 aggggttttt tgctgaaagg aggaactata tccggatctg aacaggaggg acagctgata 8700 gaaacagaag ccactggagc acctcaaaaa caccatcata cactaaatca gtaagttggc 8760 agcatcaccc gacgcacttt gcgccgaata aatacctgtg acggaagatc acttcgcaga 8820 ataaataaat cctggtgtcc ctgttgatac cgggaagccc tgggccaact tttggcgaaa 8880 atgagacgtt gatcggcacg taagaggttc caactttcac cataatgaaa taagatcact 8940 accgggcgta ttttttgagt tatcgagatt ttcaggagct aaggaagcta aaatggagaa 9000 aaaaatcact ggatatacca ccgttgatat atcccaatgg catcgtaaag aacattttga 9060 ggcatttcag tcagttgctc aatgtaccta taaccagacc gttcagctgg atattacggc 9120 ctttttaaag accgtaaaga aaaataagca caagttttat ccggccttta ttcacattct 9180 tgcccgcctg atgaatgctc atccggaatt ccgtatggca atgaaagacg gtgagctggt 9240 gatatgggat agtgttcacc cttgttacac cgttttccat gagcaaactg aaacgttttc 9300 atcgctctgg agtgaatacc acgacgattt ccggcagttt ctacacatat attcgcaaga 9360 tgtggcgtgt tacggtgaaa acctggccta tttccctaaa gggtttattg agaatatgtt 9420 tttcgtctca gccaatccct gggtgagttt caccagtttt gatttaaacg tggccaatat 9480 ggacaacttc ttcgcccccg ttttcaccat gggcaaatat tatacgcaag gcgacaaggt 9540 gctgatgccg ctggcgattc aggttcatca tgccgtttgt gatggcttcc atgtcggcag 9600 aatgcttaat gaattacaac agtactgcga tgagtggcag ggcggggcgt aattttttta 9660 aggcagttat tggtgccctt aaacgcctgg ttgctacgcc tgaataagtg ataataagcg 9720 gatgaatggc agaaattcga aagcaaattc gacccggtcg tcggttcagg gcagggtcgt 9780 taaatagccg cttatgtcta ttgctggttt accggtttat tgactaccgg aagcagtgtg 9840 accgtgtgct tctcaaatgc ctgaggccag tttgctcagg ctctccccgt ggaggtaata 9900 attgacgata tgatcattta ttctgcctcc cagctgacat tcatccgggg tcagcaccgt 9960 ttctgcggac tggctttcta cgtgttccgc ttcctttagc agcccttgcg ccctgagtgc 10020 ttgcggcagc gtgaagctaa ttctgtcagc cgttaagtgt tcctgtgtca ctcaaaattg 10080 ctttgagagg ctctaagggc ttctcagtgc gttacatccc tggcttgttg tccacaaccg 10140 ttaaacctta aaagctttaa aagccttata tattcttttt tttcttataa aacttaaaac 10200 cttagaggct atttaagttg ctgatttata ttaattttat tgttcaaaca tgagagctta 10260 gtacgtgaaa catgagagct tagtacgtta gccatgagag cttagtacgt tagccatgag 10320 ggtttagttc gttaaacatg agagcttagt acgttaaaca tgagagctta gtacgtgaaa 10380 catgagagct tagtacgtac tatcaacagg ttgaactgct gatcaacaga tcctctacgc 10440 ggccgcggta ccataacttc gtatagcata cattatacga agttatctgg tttaaacgta 10500 cccgtagtgg ctatggcagg gcttgccgcc ccgacgttgg ctgcgagccc tgggccttca 10560 cccgaacttg ggggttgggg tggggaaaag gaagaaacgc gggcgtattg gtcccaatgg 10620 ggtctcggtg gggtatcgac agagtgccag ccctgggacc gaaccccgcg tttatgaaca 10680 aacgacccaa cacccgtgcg ttttattctg tctttttatt gccgtcatag cgcgggttcc 10740 ttccggtatt gtctccttcc gtgtttcagt tagcctcccc catctcccgg taccgcatgc 10800 tatgcatcag ctgctagctt agcgagcgtc cacagcctgg ggaccgtaac gggagtgagc 10860 gggcaggttc acacgggtct gcttcagctc agggggcagg ccagcgtagt acttgtccag 10920 gtgacgcagc aggggggggt ccagctggtg acgcaggcag aattccttca cagcgttgta 10980 caggccgtag aacagggtga taccctcggg agcagcagcg gtggacacgg gcagacgcac 11040 agcacggttg gtacgggtag cctcgttacg gatagccacc accacgttga acagggaggg 11100 gggcaccagc tcgaaaccca gcacgtgttc ggtgaagatg gaacgaccgt aggacagacg 11160 agtcaggtcg taaccacggc acaggtcgtc cacgcaagtg tacacagcgg gggaaccgtc 11220 gccgcactcg gagtaaccgc gcatcacggt catccaacgg ggagcggtgt cggaggacag 11280 cagggtcagc agagcacgca gctggtcggg gttgttgtac agcagggcca gggtgtccag 11340 gaaagcgtcg tccagcagca cggagttagc agcctcgggg gtcacgggac ggtaacggat 11400 cagctgggac aggggaccgt ccctacgggt cacgttgacc aggggacgca gccaggactc 11460 gtacttgtcg ccctggaaca cctctcccag caggcaacga cgggtcagct cggggcactc 11520 agcgggcacc ttctcagcca cggtgggagc cacggacacg gtagcggagg acacgatggg 11580 cagcagcagg cagcaccaca gcagagccac gggaccgggg gagaaggaga aaccgcagtc 11640 gggacgacgg cacatggtgg ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 11700 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 11760 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 11820 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 11880 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 11940 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat gaactccaag 12000 gacctgaccc ccttcctgac caccctgtgg ctgctgctgg accactcccg tgtgcctcgt 12060 gtgcgtgctg aggaatgctg cgaagtgatc aacgtgaacc acccccccga gcgctgctac 12120 gacttcaaga tgtgcaacct gttcaccgtg gctctgcgtt gccccgacgg cgaagtgtgc 12180 tactcccccg aaaagaccgc tgagatccgt ggtatcgtga ccaccatgac ccactccctg 12240 acccgtcaag tgatccacaa caagctgacc agctgcaact acaaccccct gtacctcgag 12300 gctgacggtc gtatccgttg cggcaaggtg tccgacaagg ctcagtacct gctgggtgct 12360 gctggttccg tgccctaccg ttggatcaac ctcgagtacg acaagatcac ccgtatcgtg 12420 ggcctggacc agtacctcga gtccgtgaag aagcacaagc gtctggacgt gtgccgtgct 12480 aagatgggtt acatgctgca gtaaaagctt gtcgagaagt actagaggat cataatcagc 12540 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 12600 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 12660 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 12720 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 12780 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgtggc 12840 tagctttgtt taactttaag aaggagatac atctagaccg gaatattaat agatcatgga 12900 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 12960 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 13020 ggatccgcca ccatgctgcg tctgctgctg cgtcaccact tccactgcct gctgctgtgc 13080 gctgtgtggg ctaccccctg cctggcttcc ccctggttca ccctgaccgc taaccagaac 13140 ccctccccac cctggtccaa gctgacctac cccaagcccc acgacgctgc taccttctac 13200 tgccccttcc tgtacccatc cccacctcgt tccccatccc agttctccgg tttccagcgt 13260 gtgtccaccg gtcccgagtg ccgtaacgag actctgtacc tgctgtacaa ccgcgagggc 13320 cagaccctgg tcgagaggtc ctccacctgg gtcaagaagg tcatctggta cttgtccggt 13380 cgtaaccaga ccatcctgca gcgtatgccc cgtaccgctt ccaagccctc cgacggcaac 13440 gtgcagatct ccgtcgagga cgctaagatc ttcggtgctc acatggtgcc caagcagacc 13500 aagctgctgc gtttcgtggt caacgacggc acccgttacc agatgtgcgt gatgaagctg 13560 gaatcctggg ctcacgtgtt ccgtgactac tccgtgtcct tccaagtgcg cctgaccttc 13620 accgaggcta acaaccagac ctacaccttc tgcacccacc ccaacctgat cgtgtaagtc 13680 gacaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt 13740 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 13800 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 13860 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 13920 atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc 13980 taacaaagcc cgaaaggaag ctgagttggc tgctgggtgc ctaatgagtg agctaactca 14040 cattaattgc ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca 14100 aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt 14160 ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccggatc cgccaccatg 14220 cgtctgtgcc gtgtgtggct gtccgtgtgc ctgtgcgctg tggtgctggg acagtgccag 14280 cgtgaaaccg ctgagaagaa cgactactac cgtgtgcccc actactggga cgcttgctcc 14340 cgtgctctgc ccgaccagac ccgttacaag tacgtcgagc agctggtgga cctgaccctg 14400 aactaccact acgacgcttc ccacggcctg gacaacttcg acgtgctgaa gcgtatcaac 14460 gtgaccgagg tgtccctgct gatctccgac ttccgtcgtc agaaccgtcg tggtggcacc 14520 aacaagcgta ccaccttcaa cgctgctggt tccctggctc cccacgctcg ttccttggag 14580 ttctccgtgc gtctgttcgc caactaataa aagcttgtcg agaagtacta gaggatcata 14640 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 14700 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 14760 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 14820 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 14880 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 14940 tgccaccgct gagcaataac tatcataacc cccggaatat taatagatca tggagataat 15000 taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta 15060 ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc 15120 cggtccgaag cgcgcggaat tcaaaggcct accgtcgacg ccaccatgga atcccgtatc 15180 tggtgcctgg tcgtgtgcgt gaacctgtgc atcgtgtgcc tgggtgctgc tgtgtcctcc 15240 tcctccaccc gtggcacctc cgctacccac tcccaccact cctcccacac cacctccgcc 15300 gctcactccc gttccggttc cgtgtcccag cgtgtgacct cctcccagac cgtgtcccac 15360 ggtgtcaacg agactatcta caacaccacc ctgaagtacg gcgacgtcgt gggtgtcaac 15420 accaccaagt acccctaccg tgtgtgctcc atggctcagg gcaccgacct gatccgtttc 15480 gagcgtaaca tcgtgtgcac ctccatgaag cccatcaacg aggacctgga cgagggtatc 15540 atggtggtgt acaagcgcaa catcgtggct cacaccttca aggtccgcgt gtaccagaag 15600 gtgctgacct tccgtcgttc ctacgcttac atccacacca cttacctgct gggttccaac 15660 accgagtacg tggcccctcc catgtgggag atccaccaca tcaactccca ctcccagtgc 15720 tactcctctt actcccgtgt gatcgctggc accgtgttcg tggcttacca ccgtgactcc 15780 tacgagaaca agaccatgca gctgatgccc gacgactact ccaacaccca ctccacccgt 15840 tacgtgaccg tgaaggacca gtggcactcc cgtggttcca cctggctgta ccgtgaaacc 15900 tgcaacctga actgcatggt caccatcacc accgctcgtt ccaagtaccc ttaccacttc 15960 ttcgctacct ccaccggcga cgtggtggac atctccccct tctacaacgg tactaaccgt 16020 aacgcttcct acttcggcga gaacgctgac aagttcttca tcttccccaa ctacaccatc 16080 gtgtccgact tcggtcgtcc caactccgct ctggaaaccc accgtctggt ggctttcttg 16140 gagcgtgctg actccgtgat ctcctgggac atccaggacg agaagaacgt gacctgccag 16200 ctgaccttct gggaggcttc cgagcgtacc atccgttccg aggctgagga ctcctaccac 16260 ttctccagcg ctaagatgac cgctaccttc ctgtccaaga aacaagaggt caacatgtcc 16320 gactccgccc tggactgcgt gcgtgacgag gctatcaaca agctgcagca gatcttcaac 16380 acctcctaca accagaccta cgagaagtac ggaaacgtgt ccgtgttcga gactaccggt 16440 ggcctggtgg tgttctggca gggtatcaag cagaagtccc tggtcgagct ggaacgtctg 16500 gctaaccgtt cctccctgaa cctgacccac aaccgtacca agcgttccac cgacggcaac 16560 aacgctactc acctgtccaa catggaatcc gtgcacaacc tggtgtacgc tcagctgcag 16620 ttcacctacg acaccctgcg cggttacatc aaccgtgctc tggctcagat cgctgaggct 16680 tggtgcgtgg accagcgtcg taccctggaa gtgttcaagg aactgtccaa gatcaacccc 16740 tccgctatcc tgtccgccat ctacaacaag cctatcgctg ctcgtttcat gggcgacgtg 16800 ctgggcctgg cttcctgcgt gaccatcaac cagacttccg tgaaggtgct gcgtgacatg 16860 aacgtgaagg aatcccccgg tcgttgctac tcccgtcccg tggtcatctt caacttcgct 16920 aactcctcct acgtgcagta cggccagctg ggcgaggaca acgagatcct gctgggcaac 16980 caccgtaccg aggaatgcca gctgccctcc ctgaagatct tcatcgctgg caactccgct 17040 tacgaatacg tggactacct gttcaagcgc atgatcgacc tgtcctccat ctctaccgtg 17100 gactccatga tcgctctgga catcgacccc ctggaaaaca ccgacttccg tgtgctggaa 17160 ctgtactccc agaaggaact gcgttccatc aacgtgttcg acctggaaga gatcatgcgc 17220 gagttcaact cctacaagca gcgtgttaag tacgtcgagg acaaggtggt ggaccccctg 17280 cccccctacc tgaagggact ggacgacctg atgtccggcc tgggagctgc cggcaaggct 17340 gtgggtgtcg ctatcggtgc tgtgggtggt gctgtggctt ccgtggtcga gggtgtcgcc 17400 accttcctga agaacccctt cggtgctttc accatcatcc tggtggctat cgctgtggtc 17460 atcatcatct acctgatcta cacccgtcag cgtcgtctgt gcatgcagcc cctgcagaac 17520 ctgttcccct acctggtgtc cgctgacggt actaccgtga cctccggcaa caccaaggac 17580 acctccctgc aggctccccc atcctacgag gaatccgtct acaactccgg tcgcaagggt 17640 cccggtcccc cttcctccga cgcttctacc gctgctcccc catacaccaa cgagcaggct 17700 taccagatgc tgctggctct cgtgcgtctg gacgctgagc agcgtgcaca gcagaacggc 17760 accgactccc tggacggcca gaccggaacc caggacaagg gccagaagcc caacctgctg 17820 gaccgtctgc gtcaccgcaa gaacggttac cgtcacctga aggactccga cgaggaagag 17880 aacgtctaag gcgcgccaag cttgtcgaga agtactagag atcataatca gccataccac 17940 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 18000 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 18060 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 18120 tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag 18180 aagatccggc tgctaacaaa gcccgaaagg aagctgggaa tattaataga tcatggagat 18240 aattaaaatg ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt 18300 gtaataaaaa aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga 18360 tccgccacca tgcgtcccgg cctgccctcc tacctgatcg tgctggctgt gtgcctgctg 18420 tcccacctcc tgtcctcccg ttacggtgct gaggctatct ccgagcccct ggacaaggct 18480 ttccacctcc tgctgaacac ctacggtcgt cctatccgtt tcctgcgcga gaacaccacc 18540 cagtgcacct acaactcctc cctgcgcaac tccaccgtcg tccgcgagaa cgctatctcc 18600 ttcaacttct tccagtccta caaccagtac tacgtgttcc acatgccccg ttgcctgttc 18660 gctggtcccc tggctgagca gttcctgaac caggtggacc tgaccgagac tctcgagcgt 18720 taccagcagc gtctgaacac ttacgctctg gtgtccaagg acctggcttc ctaccgttcc 18780 ttcagccagc agctgaaggc tcaggactcc ctgggcgagc agcccaccac tgtgcctccc 18840 cctatcgacc tgtccatccc ccacgtgtgg atgccccccc agaccactcc tcacggctgg 18900 accgagtccc acaccacctc cggactgcac cgtccccact tcaaccagac ctgcatcctg 18960 ttcgacggtc acgacctgct gttctccacc gtgaccccct gcctgcacca gggcttctac 19020 ctcatcgacg agctgcgtta cgtgaagatc accctgaccg aggatttctt cgtggtcacc 19080 gtgtccatcg acgacgacac ccccatgctg ctgatcttcg gtcacctccc ccgtgtgctg 19140 ttcaaggctc cctaccagcg tgacaacttc atcctgcgtc agaccgagaa gcacgagctg 19200 ctggtgctgg tcaagaagga ccagctgaac cgtcactctt acctgaagga ccccgacttc 19260 ctggacgctg ctctggactt caactacctg gacctgtccg ctctgctgag gaactccttc 19320 caccgttacg ctgtggacgt gctgaagtcc ggtcgttgcc agatgctgga ccgtcgtacc 19380 gtcgagatgg ctttcgctta cgccctggct ctgttcgctg ctgctcgtca agaagaggct 19440 ggcgctcagg tgtccgtgcc ccgtgctctg gaccgtcagg ctgctctgct gcagatccaa 19500 gagttcatga tcacttgcct gtcccagacc ccccctcgta ccaccctgct gctgtacccc 19560 accgctgtgg acctggctaa gcgtgctctg tggaccccca accagatcac cgacatcacc 19620 tccctcgtgc gtctggtgta catcctgtcc aagcagaacc agcagcacct gatcccccag 19680 tgggctctgc gtcagatcgc tgacttcgct ctgaagctgc acaagaccca cctggcttca 19740 ttcctcagcg ctttcgctcg ccaagagctg tacctgatgg gttccctggt gcactccatg 19800 ctggtgcaca ccaccgagcg tcgcgagatc ttcatcgtgg aaaccggcct gtgctccctg 19860 gccgagctgt cccacttcac ccagctgctg gctcaccccc accacgagta cctgtccgac 19920 ctgtacaccc cctgctcctc ttccggtcgt cgtgaccact ccctggaacg tctgacccgt 19980 ctgttccccg acgctaccgt gcctaccacc gtgcctgctg ctctgtccat cctgtctacc 20040 atgcagccct ccaccctgga aaccttcccc gacctgttct gcctgcctct gggcgagtcc 20100 ttctccgctc tgaccgtgtc cgagcacgtg tcctacgtgg tcaccaacca gtacctgatc 20160 aagggcatct cctaccccgt gtccaccacc gtcgtgggcc agtccctgat catcacccag 20220 accgactccc agaccaagtg cgagctgacc cgtaacatgc acaccactca ctccatcacc 20280 gctgctctga acatctccct cgagaactgc gctttctgcc agtccgctct gttggagtac 20340 gacgacactc agggtgtcat caacatcatg tacatgcacg actccgacga cgtgctgttc 20400 gctctggacc cctacaacga ggtggtggtg tcctcccccc gtacccacta cctgatgctg 20460 ctgaagaacg gcaccgtgct ggaagtgacc gacgtggtgg tggacgctac cgaccgtctg 20520 ctgatgatgt ccgtgtacgc tctgtccgct atcatcggca tctacctgct gtaccgtatg 20580 ctgaagacct gctaaggcgc caagctttgt cgagaagtac tagaggatca taatcagcca 20640 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 20700 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 20760 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 20820 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 20880 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgccaccg 20940 ctgagcaata actatcataa cccctaggag atccgaacca gataagtgaa atctagttcc 21000 aaactatttt gtcattttta attttcgtat tagcttacga cgctacaccc agttcccatc 21060 tattttgtca ctcttcccta aataatcctt aaaaactcca tttccacccc tcccagttcc 21120 caactatttt gtccgcccac a 21141 <210> 39 <211> 22348 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 39 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgtggctagc tttgtttaac tttaagaagg agatacatct agaaatatta atagatcatg 7200 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 7260 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 7320 gcggatcccg gtccgaagcg cgcggaattc gccaccatga ccatggacga gcagcagccc 7380 caggctgtga cccccgtgta cgtgggcggt ttcctggctc gttacgacca gtcccccgac 7440 gaggctgagc tgctgctgcc acgtgacgtg gtcgaacact ggctgcacgc tcagggccag 7500 ggacagcctt ccctgtccgt ggctctgccc ctgaacatca accacgacga caccgctgtc 7560 gtgggtcacg tggccgctat gcagtccgtg cgtgacggcc tgttctgcct gggttgcgtg 7620 acctcccccc gtttcctgga aatcgtgcgt cgtgcttccg agaagtccga gctggtgtcc 7680 cgtggtcccg tgtccccact gcagcccgac aaggtggtcg agttcctgtc cggttcctac 7740 gctggcctgt ccctgtcatc ccgtcgttgc gacgacgtcg aggctgctac ctccctgagc 7800 ggctccgaga ctaccccctt caagcacgtg gccctgtgct ccgtgggtcg taggcgtgga 7860 accctggctg tgtacggtcg tgaccccgag tgggtcaccc agcgtttccc cgacctgacc 7920 gctgctgacc gtgacggact gcgtgctcag tggcagcgtt gcggttccac cgctgtggac 7980 gcttccggcg accccttccg ttccgactcc tacggcctgc tgggcaactc cgtggacgct 8040 ctgtacatcc gcgagcgtct gcccaagctg cgttacgaca agcagctcgt gggtgtcacc 8100 gagcgcgagt cctacgtgaa ggcttccgtg tcccccgagg ctgcttgcga catcaaggct 8160 gcttccgctg agcgttctgg cgacagccgc tcccaggctg ctactcctgc tgctggtgct 8220 cgtgtgccct ccagctcccc atccccacct gtcgagcctc cctcccccgt gcaacctcct 8280 gctctgcctg cttccccctc cgtgctgcct gctgagtcca gcccctccct gtcaccctct 8340 gagcctgctg aggctgcctc catgtcccac cctctgagcg ctgctgtgac tgctgctacc 8400 gctccccctg gtgctactgt ggctggtgct tcccccgctg tgccttccct ggcttggcct 8460 cacgacggtg tctacctgcc caaggacgct ttcttctccc tgctgggcgc ttcccgttcc 8520 gctgctcccg tgatgtaccc cggtgctgtg gctgctcccc ccagcgcttc acctgctcct 8580 ctgcccctgc cctcctaccc cgcttcctac ggtgctcccg tcgtgggtta cgaccagctg 8640 gctgctcgtc acttcgctga ctacgtggac ccccactacc ccggctgggg tcgtcgttac 8700 gagcccgctc cttccctgca cccatcctac cctgtgcccc ctcctccatc acccgcttac 8760 taccgtcgtc gtgactcccc cggtggcatg gacgagcctc catctggatg ggagcgttac 8820 gacggttccc accgtggcca gtcccaaaag cagcaccgtc acggtggttc cggtggtcac 8880 aacaagcgtc gcaaggaagc cgctgctgca tcctccagct ccgacgagga cctgagcttc 8940 cccggcgagg ctgaacacgg tcgtgctcgc aagcgtctga agtcccacgt gaactccgac 9000 ggaggtagcg gaggccacgc tggttccaac cagcagcagc aacagcgcta cgacgagctg 9060 cgtgacgcta tccacgagct gaagcgtgac ctgttcgctg ctcgccagtc ctccaccctg 9120 ctgtctgctg ctctgccagc tgccgcttct tcctccccta ccaccaccac cgtgtgcacc 9180 cctactggcg agctgacctc tggtggtggc gagactccca ccgctctgct gtccggtggt 9240 gctaaggtgg ccgagcgtgc tcaggctggt gtcgtgaacg cttcctgccg tctggctacc 9300 gcttccggtt ccgaggctgc caccgctggt ccctctaccg ctggttcctc atcctgccca 9360 gcttccgtgg tgctggctgc cgctgctgct caagccgccg ctgcttcaca gtccccccca 9420 aaggatatgg tggacctgaa ccgtcgtatc ttcgtggctg ctctgaacaa gctcgagtaa 9480 taaaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt 9540 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 9600 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 9660 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 9720 atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc 9780 taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactatcata 9840 acccctaggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc 9900 cggatctgaa caggagggac agctgataga aacagaagcc actggagcac ctcaaaaaca 9960 ccatcataca ctaaatcagt aagttggcag catcacccga cgcactttgc gccgaataaa 10020 tacctgtgac ggaagatcac ttcgcagaat aaataaatcc tggtgtccct gttgataccg 10080 ggaagccctg ggccaacttt tggcgaaaat gagacgttga tcggcacgta agaggttcca 10140 actttcacca taatgaaata agatcactac cgggcgtatt ttttgagtta tcgagatttt 10200 caggagctaa ggaagctaaa atggagaaaa aaatcactgg atataccacc gttgatatat 10260 cccaatggca tcgtaaagaa cattttgagg catttcagtc agttgctcaa tgtacctata 10320 accagaccgt tcagctggat attacggcct ttttaaagac cgtaaagaaa aataagcaca 10380 agttttatcc ggcctttatt cacattcttg cccgcctgat gaatgctcat ccggaattcc 10440 gtatggcaat gaaagacggt gagctggtga tatgggatag tgttcaccct tgttacaccg 10500 ttttccatga gcaaactgaa acgttttcat cgctctggag tgaataccac gacgatttcc 10560 ggcagtttct acacatatat tcgcaagatg tggcgtgtta cggtgaaaac ctggcctatt 10620 tccctaaagg gtttattgag aatatgtttt tcgtctcagc caatccctgg gtgagtttca 10680 ccagttttga tttaaacgtg gccaatatgg acaacttctt cgcccccgtt ttcaccatgg 10740 gcaaatatta tacgcaaggc gacaaggtgc tgatgccgct ggcgattcag gttcatcatg 10800 ccgtttgtga tggcttccat gtcggcagaa tgcttaatga attacaacag tactgcgatg 10860 agtggcaggg cggggcgtaa tttttttaag gcagttattg gtgcccttaa acgcctggtt 10920 gctacgcctg aataagtgat aataagcgga tgaatggcag aaattcgaaa gcaaattcga 10980 cccggtcgtc ggttcagggc agggtcgtta aatagccgct tatgtctatt gctggtttac 11040 cggtttattg actaccggaa gcagtgtgac cgtgtgcttc tcaaatgcct gaggccagtt 11100 tgctcaggct ctccccgtgg aggtaataat tgacgatatg atcatttatt ctgcctccca 11160 gctgacattc atccggggtc agcaccgttt ctgcggactg gctttctacg tgttccgctt 11220 cctttagcag cccttgcgcc ctgagtgctt gcggcagcgt gaagctaatt ctgtcagccg 11280 ttaagtgttc ctgtgtcact caaaattgct ttgagaggct ctaagggctt ctcagtgcgt 11340 tacatccctg gcttgttgtc cacaaccgtt aaaccttaaa agctttaaaa gccttatata 11400 ttcttttttt tcttataaaa cttaaaacct tagaggctat ttaagttgct gatttatatt 11460 aattttattg ttcaaacatg agagcttagt acgtgaaaca tgagagctta gtacgttagc 11520 catgagagct tagtacgtta gccatgaggg tttagttcgt taaacatgag agcttagtac 11580 gttaaacatg agagcttagt acgtgaaaca tgagagctta gtacgtacta tcaacaggtt 11640 gaactgctga tcaacagatc ctctacgcgg ccgcggtacc ataacttcgt atagcataca 11700 ttatacgaag ttatctggtt taaacgtacc cgtagtggct atggcagggc ttgccgcccc 11760 gacgttggct gcgagccctg ggccttcacc cgaacttggg ggttggggtg gggaaaagga 11820 agaaacgcgg gcgtattggt cccaatgggg tctcggtggg gtatcgacag agtgccagcc 11880 ctgggaccga accccgcgtt tatgaacaaa cgacccaaca cccgtgcgtt ttattctgtc 11940 tttttattgc cgtcatagcg cgggttcctt ccggtattgt ctccttccgt gtttcagtta 12000 gcctccccca tctcccggta ccgcatgcta tgcatcagct gctagcttag cgagcgtcca 12060 cagcctgggg accgtaacgg gagtgagcgg gcaggttcac acgggtctgc ttcagctcag 12120 ggggcaggcc agcgtagtac ttgtccaggt gacgcagcag gggggggtcc agctggtgac 12180 gcaggcagaa ttccttcaca gcgttgtaca ggccgtagaa cagggtgata ccctcgggag 12240 cagcagcggt ggacacgggc agacgcacag cacggttggt acgggtagcc tcgttacgga 12300 tagccaccac cacgttgaac agggaggggg gcaccagctc gaaacccagc acgtgttcgg 12360 tgaagatgga acgaccgtag gacagacgag tcaggtcgta accacggcac aggtcgtcca 12420 cgcaagtgta cacagcgggg gaaccgtcgc cgcactcgga gtaaccgcgc atcacggtca 12480 tccaacgggg agcggtgtcg gaggacagca gggtcagcag agcacgcagc tggtcggggt 12540 tgttgtacag cagggccagg gtgtccagga aagcgtcgtc cagcagcacg gagttagcag 12600 cctcgggggt cacgggacgg taacggatca gctgggacag gggaccgtcc ctacgggtca 12660 cgttgaccag gggacgcagc caggactcgt acttgtcgcc ctggaacacc tctcccagca 12720 ggcaacgacg ggtcagctcg gggcactcag cgggcacctt ctcagccacg gtgggagcca 12780 cggacacggt agcggaggac acgatgggca gcagcaggca gcaccacagc agagccacgg 12840 gaccggggga gaaggagaaa ccgcagtcgg gacgacggca catggtggct cgagatcccg 12900 ggtgatcaag tcttcgtcga gtgattgtaa ataaaatgta atttacagta tagtatttta 12960 attaatatac aaatgatttg ataataattc ttatttaact ataatatatt gtgttgggtt 13020 gaattaaagg tccgtatact agtatcgatt cgcgacctac tccggaatat taatagatca 13080 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 13140 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 13200 gcgcggatcc gccaccatgt cccccaagaa cctgaccccc ttcctgaccg ctctgtggct 13260 gctgctgggc cactcccgtg tgcctcgtgt gcgtgctgag gaatgctgcg agttcatcaa 13320 cgtgaaccac ccccccgagc gctgctacga cttcaagatg tgcaaccgtt tcaccgtggc 13380 tctgcgttgc cccgacggcg aagtgtgcta ctcccccgaa aagaccgctg agatccgtgg 13440 tatcgtgacc accatgaccc actccctgac ccgtcaggtg gtgcacaaca agctgacctc 13500 ttgcaactac aaccccctgt acctcgaggc tgacggtcgt atccgttgcg gcaaggtcaa 13560 cgacaaggct cagtacctgc tgggtgctgc tggttccgtg ccctaccgtt ggatcaacct 13620 cgagtacgac aagatcaccc gtatcgtggg cctggaccag tacctcgagt ccgtgaagaa 13680 gcacaagcgt ctggacgtgt gccgtgctaa gatgggttac atgctgcagt aaaagcttgt 13740 cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt 13800 aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt 13860 taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 13920 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 13980 ttatcatgtc tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc 14040 gaaaggaagc tgagttggct gctgtggcta gctttgttta actttaagaa ggagatacat 14100 ctagaccgga atattaatag atcatggaga taattaaaat gataaccatc tcgcaaataa 14160 ataagtattt tactgttttc gtaacagttt tgtaataaaa aaacctataa atattccgga 14220 ttattcatac cgtcccacca tcgggcgcgg atccgccacc atgctgcgtc tgctgctgcg 14280 tcaccacttc cactgcctgc tgctgtgcgc tgtgtgggct accccctgcc tggcttcccc 14340 ttggtccacc ctgaccgcta accagaaccc ctccccaccc tggtccaagc tgacctactc 14400 caagccccac gacgctgcta ccttctactg ccccttcctg tacccatccc cccctcgttc 14460 cccactgcag ttctccggtt tccagcgtgt gctgaccggt cccgagtgcc gtaacgagac 14520 tctgtacctg ctgtacaacc gcgagggcca gaccctggtc gagaggtcct ccacctgggt 14580 caagaaggtc atctggtact tgtccggtcg taaccagacc atcctgcagc gtatgccccg 14640 taccgcttcc aagccctccg acggcaacgt gcagatctcc gtcgaggacg ctaagatctt 14700 cggtgctcac atggtgccca agcagaccaa gctgctgcgt ttcgtggtca acgacggcac 14760 ccgttaccag atgtgcgtga tgaagctcga gtcctgggct cacgtgttcc gtgactactc 14820 cgtgtccttc caagtgcgcc tgaccttcac cgaggctaac aaccagacct acaccttctg 14880 cacccacccc aacctgatcg tgtaaaagct tgtcgagaag tactagagga tcataatcag 14940 ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa 15000 cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg 15060 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 15120 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct gatcactgct 15180 tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg gctgctgggt 15240 gcctaatgag tgagctaact cacattaatt gcccggaata ttaatagatc atggagataa 15300 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 15360 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 15420 cgccaccatg cgtctgtgcc gtgtgtggct gtccgtgtgc ctgtgcgctg tggtgctggg 15480 ccagtgccag cgtgaaaccg ctgagaagaa cgactactac cgtgtgcccc actactggga 15540 cgcttgctcc cgtgctctgc ccgaccagac ccgttacaag tacgtcgagc agctggtgga 15600 cctgaccctg aactaccact acgacgcttc ccacggcctg gacaacttcg acgtgctgaa 15660 gcgtatcaac gtgaccgagg tgtccctgct gatctccgac ttccgtcgtc agaaccgtcg 15720 tggtggcacc aacaagcgta ccaccttcaa cgctgctggt tccctggctc cccacgctcg 15780 ttccctcgag ttctccgtgc gtctgttcgc taactaaaag cttgtcgaga agtactagag 15840 gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca 15900 cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc 15960 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 16020 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat 16080 ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt 16140 tggctgctgc caccgctgag caataactat cataaccccc ggaatattaa tagatcatgg 16200 agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag 16260 ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg 16320 cggatcccgg tccgaagcgc gcggaattca aaggcctacc gtcgacgcca ccatggaatc 16380 ccgtatctgg tgcctggtcg tgtgcgtgaa cctgtgcatc gtgtgcctgg gtgctgctgt 16440 gtcctcctcc tccacccgtg gcacctccgc tacccactcc caccactcct cccacaccac 16500 ctccgccgct cactcccgtt ccggttccgt gtcccagcgt gtgacctcct cccagaccgt 16560 gtcccacggt gtcaacgaga ctatctacaa caccaccctg aagtacggcg acgtcgtggg 16620 tgtcaacacc accaagtacc cctaccgtgt gtgctccatg gctcagggca ccgacctgat 16680 ccgtttcgag cgtaacatcg tgtgcacctc catgaagccc atcaacgagg acctggacga 16740 gggtatcatg gtggtgtaca agcgcaacat cgtggctcac accttcaagg tccgcgtgta 16800 ccagaaggtg ctgaccttcc gtcgttccta cgcttacatc cacaccactt acctgctggg 16860 ttccaacacc gagtacgtgg cccctcccat gtgggagatc caccacatca actcccactc 16920 ccagtgctac tcctcttact cccgtgtgat cgctggcacc gtgttcgtgg cttaccaccg 16980 tgactcctac gagaacaaga ccatgcagct gatgcccgac gactactcca acacccactc 17040 cacccgttac gtgaccgtga aggaccagtg gcactcccgt ggttccacct ggctgtaccg 17100 tgaaacctgc aacctgaact gcatggtcac catcaccacc gctcgttcca agtaccctta 17160 ccacttcttc gctacctcca ccggcgacgt ggtggacatc tcccccttct acaacggtac 17220 taaccgtaac gcttcctact tcggcgagaa cgctgacaag ttcttcatct tccccaacta 17280 caccatcgtg tccgacttcg gtcgtcccaa ctccgctctg gaaacccacc gtctggtggc 17340 tttcttggag cgtgctgact ccgtgatctc ctgggacatc caggacgaga agaacgtgac 17400 ctgccagctg accttctggg aggcttccga gcgtaccatc cgttccgagg ctgaggactc 17460 ctaccacttc tccagcgcta agatgaccgc taccttcctg tccaagaaac aagaggtcaa 17520 catgtccgac tccgccctgg actgcgtgcg tgacgaggct atcaacaagc tgcagcagat 17580 cttcaacacc tcctacaacc agacctacga gaagtacgga aacgtgtccg tgttcgagac 17640 taccggtggc ctggtggtgt tctggcaggg tatcaagcag aagtccctgg tcgagctgga 17700 acgtctggct aaccgttcct ccctgaacct gacccacaac cgtaccaagc gttccaccga 17760 cggcaacaac gctactcacc tgtccaacat ggaatccgtg cacaacctgg tgtacgctca 17820 gctgcagttc acctacgaca ccctgcgcgg ttacatcaac cgtgctctgg ctcagatcgc 17880 tgaggcttgg tgcgtggacc agcgtcgtac cctggaagtg ttcaaggaac tgtccaagat 17940 caacccctcc gctatcctgt ccgccatcta caacaagcct atcgctgctc gtttcatggg 18000 cgacgtgctg ggcctggctt cctgcgtgac catcaaccag acttccgtga aggtgctgcg 18060 tgacatgaac gtgaaggaat cccccggtcg ttgctactcc cgtcccgtgg tcatcttcaa 18120 cttcgctaac tcctcctacg tgcagtacgg ccagctgggc gaggacaacg agatcctgct 18180 gggcaaccac cgtaccgagg aatgccagct gccctccctg aagatcttca tcgctggcaa 18240 ctccgcttac gaatacgtgg actacctgtt caagcgcatg atcgacctgt cctccatctc 18300 taccgtggac tccatgatcg ctctggacat cgaccccctg gaaaacaccg acttccgtgt 18360 gctggaactg tactcccaga aggaactgcg ttccatcaac gtgttcgacc tggaagagat 18420 catgcgcgag ttcaactcct acaagcagcg tgttaagtac gtcgaggaca aggtggtgga 18480 ccccctgccc ccctacctga agggactgga cgacctgatg tccggcctgg gagctgccgg 18540 caaggctgtg ggtgtcgcta tcggtgctgt gggtggtgct gtggcttccg tggtcgaggg 18600 tgtcgccacc ttcctgaaga accccttcgg tgctttcacc atcatcctgg tggctatcgc 18660 tgtggtcatc atcatctacc tgatctacac ccgtcagcgt cgtctgtgca tgcagcccct 18720 gcagaacctg ttcccctacc tggtgtccgc tgacggtact accgtgacct ccggcaacac 18780 caaggacacc tccctgcagg ctcccccatc ctacgaggaa tccgtctaca actccggtcg 18840 caagggtccc ggtccccctt cctccgacgc ttctaccgct gctcccccat acaccaacga 18900 gcaggcttac cagatgctgc tggctctcgt gcgtctggac gctgagcagc gtgcacagca 18960 gaacggcacc gactccctgg acggccagac cggaacccag gacaagggcc agaagcccaa 19020 cctgctggac cgtctgcgtc accgcaagaa cggttaccgt cacctgaagg actccgacga 19080 ggaagagaac gtctaaggcg cgccaagctt gtcgagaagt actagagatc ataatcagcc 19140 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 19200 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 19260 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 19320 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 19380 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgggaatat taatagatca 19440 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 19500 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 19560 gcgcggatcc gccaccatgc gtcccggcct gccctcctac ctgatcgtgc tggctgtgtg 19620 cctgctgtcc cacctcctgt cctcccgtta cggtgctgag gctatctccg agcccctgga 19680 caaggctttc cacctcctgc tgaacaccta cggtcgtcct atccgtttcc tgcgcgagaa 19740 caccacccag tgcacctaca actcctccct gcgcaactcc accgtcgtcc gcgagaacgc 19800 tatctccttc aacttcttcc agtcctacaa ccagtactac gtgttccaca tgccccgttg 19860 cctgttcgct ggtcccctgg ctgagcagtt cctgaaccag gtggacctga ccgagactct 19920 cgagcgttac cagcagcgtc tgaacactta cgctctggtg tccaaggacc tggcttccta 19980 ccgttccttc agccagcagc tgaaggctca ggactccctg ggcgagcagc ccaccactgt 20040 gcctccccct atcgacctgt ccatccccca cgtgtggatg cccccccaga ccactcctca 20100 cggctggacc gagtcccaca ccacctccgg actgcaccgt ccccacttca accagacctg 20160 catcctgttc gacggtcacg acctgctgtt ctccaccgtg accccctgcc tgcaccaggg 20220 cttctacctc atcgacgagc tgcgttacgt gaagatcacc ctgaccgagg atttcttcgt 20280 ggtcaccgtg tccatcgacg acgacacccc catgctgctg atcttcggtc acctcccccg 20340 tgtgctgttc aaggctccct accagcgtga caacttcatc ctgcgtcaga ccgagaagca 20400 cgagctgctg gtgctggtca agaaggacca gctgaaccgt cactcttacc tgaaggaccc 20460 cgacttcctg gacgctgctc tggacttcaa ctacctggac ctgtccgctc tgctgaggaa 20520 ctccttccac cgttacgctg tggacgtgct gaagtccggt cgttgccaga tgctggaccg 20580 tcgtaccgtc gagatggctt tcgcttacgc cctggctctg ttcgctgctg ctcgtcaaga 20640 agaggctggc gctcaggtgt ccgtgccccg tgctctggac cgtcaggctg ctctgctgca 20700 gatccaagag ttcatgatca cttgcctgtc ccagaccccc cctcgtacca ccctgctgct 20760 gtaccccacc gctgtggacc tggctaagcg tgctctgtgg acccccaacc agatcaccga 20820 catcacctcc ctcgtgcgtc tggtgtacat cctgtccaag cagaaccagc agcacctgat 20880 cccccagtgg gctctgcgtc agatcgctga cttcgctctg aagctgcaca agacccacct 20940 ggcttcattc ctcagcgctt tcgctcgcca agagctgtac ctgatgggtt ccctggtgca 21000 ctccatgctg gtgcacacca ccgagcgtcg cgagatcttc atcgtggaaa ccggcctgtg 21060 ctccctggcc gagctgtccc acttcaccca gctgctggct cacccccacc acgagtacct 21120 gtccgacctg tacaccccct gctcctcttc cggtcgtcgt gaccactccc tggaacgtct 21180 gacccgtctg ttccccgacg ctaccgtgcc taccaccgtg cctgctgctc tgtccatcct 21240 gtctaccatg cagccctcca ccctggaaac cttccccgac ctgttctgcc tgcctctggg 21300 cgagtccttc tccgctctga ccgtgtccga gcacgtgtcc tacgtggtca ccaaccagta 21360 cctgatcaag ggcatctcct accccgtgtc caccaccgtc gtgggccagt ccctgatcat 21420 cacccagacc gactcccaga ccaagtgcga gctgacccgt aacatgcaca ccactcactc 21480 catcaccgct gctctgaaca tctccctcga gaactgcgct ttctgccagt ccgctctgtt 21540 ggagtacgac gacactcagg gtgtcatcaa catcatgtac atgcacgact ccgacgacgt 21600 gctgttcgct ctggacccct acaacgaggt ggtggtgtcc tccccccgta cccactacct 21660 gatgctgctg aagaacggca ccgtgctgga agtgaccgac gtggtggtgg acgctaccga 21720 ccgtctgctg atgatgtccg tgtacgctct gtccgctatc atcggcatct acctgctgta 21780 ccgtatgctg aagacctgct aaggcgccaa gctttgtcga gaagtactag aggatcataa 21840 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 21900 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 21960 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 22020 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 22080 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 22140 gccaccgctg agcaataact atcataaccc ctaggagatc cgaaccagat aagtgaaatc 22200 tagttccaaa ctattttgtc atttttaatt ttcgtattag cttacgacgc tacacccagt 22260 tcccatctat tttgtcactc ttccctaaat aatccttaaa aactccattt ccacccctcc 22320 cagttcccaa ctattttgtc cgcccaca 22348 <210> 40 <211> 22348 <212> DNA <213> Artificial <220> <223> Synthetic sequence <400> 40 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgtggctagc tttgtttaac tttaagaagg agatacatct agaaatatta atagatcatg 7200 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 7260 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 7320 gcggatcccg gtccgaagcg cgcggaattc gccaccatga ccatggacga gcagcagccc 7380 caggctgtga cccccgtgta cgtgggcggt ttcctggctc gttacgacca gtcccccgac 7440 gaggctgagc tgctgctgcc acgtgacgtg gtcgaacact ggctgcacgc tcagggccag 7500 ggacagcctt ccctgtccgt ggctctgccc ctgaacatca accacgacga caccgctgtc 7560 gtgggtcacg tggccgctat gcagtccgtg cgtgacggcc tgttctgcct gggttgcgtg 7620 acctcccccc gtttcctgga aatcgtgcgt cgtgcttccg agaagtccga gctggtgtcc 7680 cgtggtcccg tgtccccact gcagcccgac aaggtggtcg agttcctgtc cggttcctac 7740 gctggcctgt ccctgtcatc ccgtcgttgc gacgacgtcg aggctgctac ctccctgagc 7800 ggctccgaga ctaccccctt caagcacgtg gccctgtgct ccgtgggtcg taggcgtgga 7860 accctggctg tgtacggtcg tgaccccgag tgggtcaccc agcgtttccc cgacctgacc 7920 gctgctgacc gtgacggact gcgtgctcag tggcagcgtt gcggttccac cgctgtggac 7980 gcttccggcg accccttccg ttccgactcc tacggcctgc tgggcaactc cgtggacgct 8040 ctgtacatcc gcgagcgtct gcccaagctg cgttacgaca agcagctcgt gggtgtcacc 8100 gagcgcgagt cctacgtgaa ggcttccgtg tcccccgagg ctgcttgcga catcaaggct 8160 gcttccgctg agcgttctgg cgacagccgc tcccaggctg ctactcctgc tgctggtgct 8220 cgtgtgccct ccagctcccc atccccacct gtcgagcctc cctcccccgt gcaacctcct 8280 gctctgcctg cttccccctc cgtgctgcct gctgagtcca gcccctccct gtcaccctct 8340 gagcctgctg aggctgcctc catgtcccac cctctgagcg ctgctgtgac tgctgctacc 8400 gctccccctg gtgctactgt ggctggtgct tcccccgctg tgccttccct ggcttggcct 8460 cacgacggtg tctacctgcc caaggacgct ttcttctccc tgctgggcgc ttcccgttcc 8520 gctgctcccg tgatgtaccc cggtgctgtg gctgctcccc ccagcgcttc acctgctcct 8580 ctgcccctgc cctcctaccc cgcttcctac ggtgctcccg tcgtgggtta cgaccagctg 8640 gctgctcgtc acttcgctga ctacgtggac ccccactacc ccggctgggg tcgtcgttac 8700 gagcccgctc cttccctgca cccatcctac cctgtgcccc ctcctccatc acccgcttac 8760 taccgtcgtc gtgactcccc cggtggcatg gacgagcctc catctggatg ggagcgttac 8820 gacggttccc accgtggcca gtcccaaaag cagcaccgtc acggtggttc cggtggtcac 8880 aacaagcgtc gcaaggaagc cgctgctgca tcctccagct ccgacgagga cctgagcttc 8940 cccggcgagg ctgaacacgg tcgtgctcgc aagcgtctga agtcccacgt gaactccgac 9000 ggaggtagcg gaggccacgc tggttccaac cagcagcagc aacagcgcta cgacgagctg 9060 cgtgacgcta tccacgagct gaagcgtgac ctgttcgctg ctcgccagtc ctccaccctg 9120 ctgtctgctg ctctgccagc tgccgcttct tcctccccta ccaccaccac cgtgtgcacc 9180 cctactggcg agctgacctc tggtggtggc gagactccca ccgctctgct gtccggtggt 9240 gctaaggtgg ccgagcgtgc tcaggctggt gtcgtgaacg cttcctgccg tctggctacc 9300 gcttccggtt ccgaggctgc caccgctggt ccctctaccg ctggttcctc atcctgccca 9360 gcttccgtgg tgctggctgc cgctgctgct caagccgccg ctgcttcaca gtccccccca 9420 aaggatatgg tggacctgaa ccgtcgtatc ttcgtggctg ctctgaacaa gctcgagtaa 9480 taaaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt 9540 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 9600 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 9660 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 9720 atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc 9780 taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactatcata 9840 acccctaggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc 9900 cggatctgaa caggagggac agctgataga aacagaagcc actggagcac ctcaaaaaca 9960 ccatcataca ctaaatcagt aagttggcag catcacccga cgcactttgc gccgaataaa 10020 tacctgtgac ggaagatcac ttcgcagaat aaataaatcc tggtgtccct gttgataccg 10080 ggaagccctg ggccaacttt tggcgaaaat gagacgttga tcggcacgta agaggttcca 10140 actttcacca taatgaaata agatcactac cgggcgtatt ttttgagtta tcgagatttt 10200 caggagctaa ggaagctaaa atggagaaaa aaatcactgg atataccacc gttgatatat 10260 cccaatggca tcgtaaagaa cattttgagg catttcagtc agttgctcaa tgtacctata 10320 accagaccgt tcagctggat attacggcct ttttaaagac cgtaaagaaa aataagcaca 10380 agttttatcc ggcctttatt cacattcttg cccgcctgat gaatgctcat ccggaattcc 10440 gtatggcaat gaaagacggt gagctggtga tatgggatag tgttcaccct tgttacaccg 10500 ttttccatga gcaaactgaa acgttttcat cgctctggag tgaataccac gacgatttcc 10560 ggcagtttct acacatatat tcgcaagatg tggcgtgtta cggtgaaaac ctggcctatt 10620 tccctaaagg gtttattgag aatatgtttt tcgtctcagc caatccctgg gtgagtttca 10680 ccagttttga tttaaacgtg gccaatatgg acaacttctt cgcccccgtt ttcaccatgg 10740 gcaaatatta tacgcaaggc gacaaggtgc tgatgccgct ggcgattcag gttcatcatg 10800 ccgtttgtga tggcttccat gtcggcagaa tgcttaatga attacaacag tactgcgatg 10860 agtggcaggg cggggcgtaa tttttttaag gcagttattg gtgcccttaa acgcctggtt 10920 gctacgcctg aataagtgat aataagcgga tgaatggcag aaattcgaaa gcaaattcga 10980 cccggtcgtc ggttcagggc agggtcgtta aatagccgct tatgtctatt gctggtttac 11040 cggtttattg actaccggaa gcagtgtgac cgtgtgcttc tcaaatgcct gaggccagtt 11100 tgctcaggct ctccccgtgg aggtaataat tgacgatatg atcatttatt ctgcctccca 11160 gctgacattc atccggggtc agcaccgttt ctgcggactg gctttctacg tgttccgctt 11220 cctttagcag cccttgcgcc ctgagtgctt gcggcagcgt gaagctaatt ctgtcagccg 11280 ttaagtgttc ctgtgtcact caaaattgct ttgagaggct ctaagggctt ctcagtgcgt 11340 tacatccctg gcttgttgtc cacaaccgtt aaaccttaaa agctttaaaa gccttatata 11400 ttcttttttt tcttataaaa cttaaaacct tagaggctat ttaagttgct gatttatatt 11460 aattttattg ttcaaacatg agagcttagt acgtgaaaca tgagagctta gtacgttagc 11520 catgagagct tagtacgtta gccatgaggg tttagttcgt taaacatgag agcttagtac 11580 gttaaacatg agagcttagt acgtgaaaca tgagagctta gtacgtacta tcaacaggtt 11640 gaactgctga tcaacagatc ctctacgcgg ccgcggtacc ataacttcgt atagcataca 11700 ttatacgaag ttatctggtt taaacgtacc cgtagtggct atggcagggc ttgccgcccc 11760 gacgttggct gcgagccctg ggccttcacc cgaacttggg ggttggggtg gggaaaagga 11820 agaaacgcgg gcgtattggt cccaatgggg tctcggtggg gtatcgacag agtgccagcc 11880 ctgggaccga accccgcgtt tatgaacaaa cgacccaaca cccgtgcgtt ttattctgtc 11940 tttttattgc cgtcatagcg cgggttcctt ccggtattgt ctccttccgt gtttcagtta 12000 gcctccccca tctcccggta ccgcatgcta tgcatcagct gctagcttag cgagcgtcca 12060 cagcctgggg accgtaacgg gagtgagcgg gcaggttcac acgggtctgc ttcagctcag 12120 ggggcaggcc agcgtagtac ttgtccaggt gacgcagcag gggggggtcc agctggtgac 12180 gcaggcagaa ttccttcaca gcgttgtaca ggccgtagaa cagggtgata ccctcgggag 12240 cagcagcggt ggacacgggc agacgcacag cacggttggt acgggtagcc tcgttacgga 12300 tagccaccac cacgttgaac agggaggggg gcaccagctc gaaacccagc acgtgttcgg 12360 tgaagatgga acgaccgtag gacagacgag tcaggtcgta accacggcac aggtcgtcca 12420 cgcaagtgta cacagcgggg gaaccgtcgc cgcactcgga gtaaccgcgc atcacggtca 12480 tccaacgggg agcggtgtcg gaggacagca gggtcagcag agcacgcagc tggtcggggt 12540 tgttgtacag cagggccagg gtgtccagga aagcgtcgtc cagcagcacg gagttagcag 12600 cctcgggggt cacgggacgg taacggatca gctgggacag gggaccgtcc ctacgggtca 12660 cgttgaccag gggacgcagc caggactcgt acttgtcgcc ctggaacacc tctcccagca 12720 ggcaacgacg ggtcagctcg gggcactcag cgggcacctt ctcagccacg gtgggagcca 12780 cggacacggt agcggaggac acgatgggca gcagcaggca gcaccacagc agagccacgg 12840 gaccggggga gaaggagaaa ccgcagtcgg gacgacggca catggtggct cgagatcccg 12900 ggtgatcaag tcttcgtcga gtgattgtaa ataaaatgta atttacagta tagtatttta 12960 attaatatac aaatgatttg ataataattc ttatttaact ataatatatt gtgttgggtt 13020 gaattaaagg tccgtatact agtatcgatt cgcgacctac tccggaatat taatagatca 13080 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 13140 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 13200 gcgcggatcc gccaccatga actccaagga cctgaccccc ttcctgacca ccctgtggct 13260 gctgctggac cactcccgtg tgcctcgtgt gcgtgctgag gaatgctgcg aagtgatcaa 13320 cgtgaaccac ccccccgagc gctgctacga cttcaagatg tgcaacctgt tcaccgtggc 13380 tctgcgttgc cccgacggcg aagtgtgcta ctcccccgaa aagaccgctg agatccgtgg 13440 tatcgtgacc accatgaccc actccctgac ccgtcaagtg atccacaaca agctgaccag 13500 ctgcaactac aaccccctgt acctcgaggc tgacggtcgt atccgttgcg gcaaggtgtc 13560 cgacaaggct cagtacctgc tgggtgctgc tggttccgtg ccctaccgtt ggatcaacct 13620 cgagtacgac aagatcaccc gtatcgtggg cctggaccag tacctcgagt ccgtgaagaa 13680 gcacaagcgt ctggacgtgt gccgtgctaa gatgggttac atgctgcagt aaaagcttgt 13740 cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt 13800 aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt 13860 taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 13920 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 13980 ttatcatgtc tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc 14040 gaaaggaagc tgagttggct gctgtggcta gctttgttta actttaagaa ggagatacat 14100 ctagaccgga atattaatag atcatggaga taattaaaat gataaccatc tcgcaaataa 14160 ataagtattt tactgttttc gtaacagttt tgtaataaaa aaacctataa atattccgga 14220 ttattcatac cgtcccacca tcgggcgcgg atccgccacc atgctgcgtc tgctgctgcg 14280 tcaccacttc cactgcctgc tgctgtgcgc tgtgtgggct accccctgcc tggcttcccc 14340 ttggtccacc ctgaccgcta accagaaccc ctccccaccc tggtccaagc tgacctactc 14400 caagccccac gacgctgcta ccttctactg ccccttcctg tacccatccc cccctcgttc 14460 cccactgcag ttctccggtt tccagcgtgt gctgaccggt cccgagtgcc gtaacgagac 14520 tctgtacctg ctgtacaacc gcgagggcca gaccctggtc gagaggtcct ccacctgggt 14580 caagaaggtc atctggtact tgtccggtcg taaccagacc atcctgcagc gtatgccccg 14640 taccgcttcc aagccctccg acggcaacgt gcagatctcc gtcgaggacg ctaagatctt 14700 cggtgctcac atggtgccca agcagaccaa gctgctgcgt ttcgtggtca acgacggcac 14760 ccgttaccag atgtgcgtga tgaagctcga gtcctgggct cacgtgttcc gtgactactc 14820 cgtgtccttc caagtgcgcc tgaccttcac cgaggctaac aaccagacct acaccttctg 14880 cacccacccc aacctgatcg tgtaaaagct tgtcgagaag tactagagga tcataatcag 14940 ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa 15000 cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg 15060 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 15120 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct gatcactgct 15180 tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg gctgctgggt 15240 gcctaatgag tgagctaact cacattaatt gcccggaata ttaatagatc atggagataa 15300 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 15360 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 15420 cgccaccatg cgtctgtgcc gtgtgtggct gtccgtgtgc ctgtgcgctg tggtgctggg 15480 ccagtgccag cgtgaaaccg ctgagaagaa cgactactac cgtgtgcccc actactggga 15540 cgcttgctcc cgtgctctgc ccgaccagac ccgttacaag tacgtcgagc agctggtgga 15600 cctgaccctg aactaccact acgacgcttc ccacggcctg gacaacttcg acgtgctgaa 15660 gcgtatcaac gtgaccgagg tgtccctgct gatctccgac ttccgtcgtc agaaccgtcg 15720 tggtggcacc aacaagcgta ccaccttcaa cgctgctggt tccctggctc cccacgctcg 15780 ttccctcgag ttctccgtgc gtctgttcgc taactaaaag cttgtcgaga agtactagag 15840 gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca 15900 cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc 15960 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 16020 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat 16080 ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt 16140 tggctgctgc caccgctgag caataactat cataaccccc ggaatattaa tagatcatgg 16200 agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag 16260 ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg 16320 cggatcccgg tccgaagcgc gcggaattca aaggcctacc gtcgacgcca ccatggaatc 16380 ccgtatctgg tgcctggtcg tgtgcgtgaa cctgtgcatc gtgtgcctgg gtgctgctgt 16440 gtcctcctcc tccacccgtg gcacctccgc tacccactcc caccactcct cccacaccac 16500 ctccgccgct cactcccgtt ccggttccgt gtcccagcgt gtgacctcct cccagaccgt 16560 gtcccacggt gtcaacgaga ctatctacaa caccaccctg aagtacggcg acgtcgtggg 16620 tgtcaacacc accaagtacc cctaccgtgt gtgctccatg gctcagggca ccgacctgat 16680 ccgtttcgag cgtaacatcg tgtgcacctc catgaagccc atcaacgagg acctggacga 16740 gggtatcatg gtggtgtaca agcgcaacat cgtggctcac accttcaagg tccgcgtgta 16800 ccagaaggtg ctgaccttcc gtcgttccta cgcttacatc cacaccactt acctgctggg 16860 ttccaacacc gagtacgtgg cccctcccat gtgggagatc caccacatca actcccactc 16920 ccagtgctac tcctcttact cccgtgtgat cgctggcacc gtgttcgtgg cttaccaccg 16980 tgactcctac gagaacaaga ccatgcagct gatgcccgac gactactcca acacccactc 17040 cacccgttac gtgaccgtga aggaccagtg gcactcccgt ggttccacct ggctgtaccg 17100 tgaaacctgc aacctgaact gcatggtcac catcaccacc gctcgttcca agtaccctta 17160 ccacttcttc gctacctcca ccggcgacgt ggtggacatc tcccccttct acaacggtac 17220 taaccgtaac gcttcctact tcggcgagaa cgctgacaag ttcttcatct tccccaacta 17280 caccatcgtg tccgacttcg gtcgtcccaa ctccgctctg gaaacccacc gtctggtggc 17340 tttcttggag cgtgctgact ccgtgatctc ctgggacatc caggacgaga agaacgtgac 17400 ctgccagctg accttctggg aggcttccga gcgtaccatc cgttccgagg ctgaggactc 17460 ctaccacttc tccagcgcta agatgaccgc taccttcctg tccaagaaac aagaggtcaa 17520 catgtccgac tccgccctgg actgcgtgcg tgacgaggct atcaacaagc tgcagcagat 17580 cttcaacacc tcctacaacc agacctacga gaagtacgga aacgtgtccg tgttcgagac 17640 taccggtggc ctggtggtgt tctggcaggg tatcaagcag aagtccctgg tcgagctgga 17700 acgtctggct aaccgttcct ccctgaacct gacccacaac cgtaccaagc gttccaccga 17760 cggcaacaac gctactcacc tgtccaacat ggaatccgtg cacaacctgg tgtacgctca 17820 gctgcagttc acctacgaca ccctgcgcgg ttacatcaac cgtgctctgg ctcagatcgc 17880 tgaggcttgg tgcgtggacc agcgtcgtac cctggaagtg ttcaaggaac tgtccaagat 17940 caacccctcc gctatcctgt ccgccatcta caacaagcct atcgctgctc gtttcatggg 18000 cgacgtgctg ggcctggctt cctgcgtgac catcaaccag acttccgtga aggtgctgcg 18060 tgacatgaac gtgaaggaat cccccggtcg ttgctactcc cgtcccgtgg tcatcttcaa 18120 cttcgctaac tcctcctacg tgcagtacgg ccagctgggc gaggacaacg agatcctgct 18180 gggcaaccac cgtaccgagg aatgccagct gccctccctg aagatcttca tcgctggcaa 18240 ctccgcttac gaatacgtgg actacctgtt caagcgcatg atcgacctgt cctccatctc 18300 taccgtggac tccatgatcg ctctggacat cgaccccctg gaaaacaccg acttccgtgt 18360 gctggaactg tactcccaga aggaactgcg ttccatcaac gtgttcgacc tggaagagat 18420 catgcgcgag ttcaactcct acaagcagcg tgttaagtac gtcgaggaca aggtggtgga 18480 ccccctgccc ccctacctga agggactgga cgacctgatg tccggcctgg gagctgccgg 18540 caaggctgtg ggtgtcgcta tcggtgctgt gggtggtgct gtggcttccg tggtcgaggg 18600 tgtcgccacc ttcctgaaga accccttcgg tgctttcacc atcatcctgg tggctatcgc 18660 tgtggtcatc atcatctacc tgatctacac ccgtcagcgt cgtctgtgca tgcagcccct 18720 gcagaacctg ttcccctacc tggtgtccgc tgacggtact accgtgacct ccggcaacac 18780 caaggacacc tccctgcagg ctcccccatc ctacgaggaa tccgtctaca actccggtcg 18840 caagggtccc ggtccccctt cctccgacgc ttctaccgct gctcccccat acaccaacga 18900 gcaggcttac cagatgctgc tggctctcgt gcgtctggac gctgagcagc gtgcacagca 18960 gaacggcacc gactccctgg acggccagac cggaacccag gacaagggcc agaagcccaa 19020 cctgctggac cgtctgcgtc accgcaagaa cggttaccgt cacctgaagg actccgacga 19080 ggaagagaac gtctaaggcg cgccaagctt gtcgagaagt actagagatc ataatcagcc 19140 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 19200 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 19260 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 19320 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 19380 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgggaatat taatagatca 19440 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 19500 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 19560 gcgcggatcc gccaccatgc gtcccggcct gccctcctac ctgatcgtgc tggctgtgtg 19620 cctgctgtcc cacctcctgt cctcccgtta cggtgctgag gctatctccg agcccctgga 19680 caaggctttc cacctcctgc tgaacaccta cggtcgtcct atccgtttcc tgcgcgagaa 19740 caccacccag tgcacctaca actcctccct gcgcaactcc accgtcgtcc gcgagaacgc 19800 tatctccttc aacttcttcc agtcctacaa ccagtactac gtgttccaca tgccccgttg 19860 cctgttcgct ggtcccctgg ctgagcagtt cctgaaccag gtggacctga ccgagactct 19920 cgagcgttac cagcagcgtc tgaacactta cgctctggtg tccaaggacc tggcttccta 19980 ccgttccttc agccagcagc tgaaggctca ggactccctg ggcgagcagc ccaccactgt 20040 gcctccccct atcgacctgt ccatccccca cgtgtggatg cccccccaga ccactcctca 20100 cggctggacc gagtcccaca ccacctccgg actgcaccgt ccccacttca accagacctg 20160 catcctgttc gacggtcacg acctgctgtt ctccaccgtg accccctgcc tgcaccaggg 20220 cttctacctc atcgacgagc tgcgttacgt gaagatcacc ctgaccgagg atttcttcgt 20280 ggtcaccgtg tccatcgacg acgacacccc catgctgctg atcttcggtc acctcccccg 20340 tgtgctgttc aaggctccct accagcgtga caacttcatc ctgcgtcaga ccgagaagca 20400 cgagctgctg gtgctggtca agaaggacca gctgaaccgt cactcttacc tgaaggaccc 20460 cgacttcctg gacgctgctc tggacttcaa ctacctggac ctgtccgctc tgctgaggaa 20520 ctccttccac cgttacgctg tggacgtgct gaagtccggt cgttgccaga tgctggaccg 20580 tcgtaccgtc gagatggctt tcgcttacgc cctggctctg ttcgctgctg ctcgtcaaga 20640 agaggctggc gctcaggtgt ccgtgccccg tgctctggac cgtcaggctg ctctgctgca 20700 gatccaagag ttcatgatca cttgcctgtc ccagaccccc cctcgtacca ccctgctgct 20760 gtaccccacc gctgtggacc tggctaagcg tgctctgtgg acccccaacc agatcaccga 20820 catcacctcc ctcgtgcgtc tggtgtacat cctgtccaag cagaaccagc agcacctgat 20880 cccccagtgg gctctgcgtc agatcgctga cttcgctctg aagctgcaca agacccacct 20940 ggcttcattc ctcagcgctt tcgctcgcca agagctgtac ctgatgggtt ccctggtgca 21000 ctccatgctg gtgcacacca ccgagcgtcg cgagatcttc atcgtggaaa ccggcctgtg 21060 ctccctggcc gagctgtccc acttcaccca gctgctggct cacccccacc acgagtacct 21120 gtccgacctg tacaccccct gctcctcttc cggtcgtcgt gaccactccc tggaacgtct 21180 gacccgtctg ttccccgacg ctaccgtgcc taccaccgtg cctgctgctc tgtccatcct 21240 gtctaccatg cagccctcca ccctggaaac cttccccgac ctgttctgcc tgcctctggg 21300 cgagtccttc tccgctctga ccgtgtccga gcacgtgtcc tacgtggtca ccaaccagta 21360 cctgatcaag ggcatctcct accccgtgtc caccaccgtc gtgggccagt ccctgatcat 21420 cacccagacc gactcccaga ccaagtgcga gctgacccgt aacatgcaca ccactcactc 21480 catcaccgct gctctgaaca tctccctcga gaactgcgct ttctgccagt ccgctctgtt 21540 ggagtacgac gacactcagg gtgtcatcaa catcatgtac atgcacgact ccgacgacgt 21600 gctgttcgct ctggacccct acaacgaggt ggtggtgtcc tccccccgta cccactacct 21660 gatgctgctg aagaacggca ccgtgctgga agtgaccgac gtggtggtgg acgctaccga 21720 ccgtctgctg atgatgtccg tgtacgctct gtccgctatc atcggcatct acctgctgta 21780 ccgtatgctg aagacctgct aaggcgccaa gctttgtcga gaagtactag aggatcataa 21840 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 21900 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 21960 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 22020 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 22080 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 22140 gccaccgctg agcaataact atcataaccc ctaggagatc cgaaccagat aagtgaaatc 22200 tagttccaaa ctattttgtc atttttaatt ttcgtattag cttacgacgc tacacccagt 22260 tcccatctat tttgtcactc ttccctaaat aatccttaaa aactccattt ccacccctcc 22320 cagttcccaa ctattttgtc cgcccaca 22348 <210> 41 <211> 22369 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 41 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgtggctagc tttgtttaac tttaagaagg agatacatct agaaatatta atagatcatg 7200 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 7260 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 7320 gcggatcccg gtccgaagcg cgcggaattc gccaccatga ccatggacga gcagcagccc 7380 caggctgtga cccccgtgta cgtgggcggt ttcctggctc gttacgacca gtcccccgac 7440 gaggctgagc tgctgctgcc acgtgacgtg gtcgaacact ggctgcacgc tcagggccag 7500 ggacagcctt ccctgtccgt ggctctgccc ctgaacatca accacgacga caccgctgtc 7560 gtgggtcacg tggccgctat gcagtccgtg cgtgacggcc tgttctgcct gggttgcgtg 7620 acctcccccc gtttcctgga aatcgtgcgt cgtgcttccg agaagtccga gctggtgtcc 7680 cgtggtcccg tgtccccact gcagcccgac aaggtggtcg agttcctgtc cggttcctac 7740 gctggcctgt ccctgtcatc ccgtcgttgc gacgacgtcg aggctgctac ctccctgagc 7800 ggctccgaga ctaccccctt caagcacgtg gccctgtgct ccgtgggtcg taggcgtgga 7860 accctggctg tgtacggtcg tgaccccgag tgggtcaccc agcgtttccc cgacctgacc 7920 gctgctgacc gtgacggact gcgtgctcag tggcagcgtt gcggttccac cgctgtggac 7980 gcttccggcg accccttccg ttccgactcc tacggcctgc tgggcaactc cgtggacgct 8040 ctgtacatcc gcgagcgtct gcccaagctg cgttacgaca agcagctcgt gggtgtcacc 8100 gagcgcgagt cctacgtgaa ggcttccgtg tcccccgagg ctgcttgcga catcaaggct 8160 gcttccgctg agcgttctgg cgacagccgc tcccaggctg ctactcctgc tgctggtgct 8220 cgtgtgccct ccagctcccc atccccacct gtcgagcctc cctcccccgt gcaacctcct 8280 gctctgcctg cttccccctc cgtgctgcct gctgagtcca gcccctccct gtcaccctct 8340 gagcctgctg aggctgcctc catgtcccac cctctgagcg ctgctgtgac tgctgctacc 8400 gctccccctg gtgctactgt ggctggtgct tcccccgctg tgccttccct ggcttggcct 8460 cacgacggtg tctacctgcc caaggacgct ttcttctccc tgctgggcgc ttcccgttcc 8520 gctgctcccg tgatgtaccc cggtgctgtg gctgctcccc ccagcgcttc acctgctcct 8580 ctgcccctgc cctcctaccc cgcttcctac ggtgctcccg tcgtgggtta cgaccagctg 8640 gctgctcgtc acttcgctga ctacgtggac ccccactacc ccggctgggg tcgtcgttac 8700 gagcccgctc cttccctgca cccatcctac cctgtgcccc ctcctccatc acccgcttac 8760 taccgtcgtc gtgactcccc cggtggcatg gacgagcctc catctggatg ggagcgttac 8820 gacggttccc accgtggcca gtcccaaaag cagcaccgtc acggtggttc cggtggtcac 8880 aacaagcgtc gcaaggaagc cgctgctgca tcctccagct ccgacgagga cctgagcttc 8940 cccggcgagg ctgaacacgg tcgtgctcgc aagcgtctga agtcccacgt gaactccgac 9000 ggaggtagcg gaggccacgc tggttccaac cagcagcagc aacagcgcta cgacgagctg 9060 cgtgacgcta tccacgagct gaagcgtgac ctgttcgctg ctcgccagtc ctccaccctg 9120 ctgtctgctg ctctgccagc tgccgcttct tcctccccta ccaccaccac cgtgtgcacc 9180 cctactggcg agctgacctc tggtggtggc gagactccca ccgctctgct gtccggtggt 9240 gctaaggtgg ccgagcgtgc tcaggctggt gtcgtgaacg cttcctgccg tctggctacc 9300 gcttccggtt ccgaggctgc caccgctggt ccctctaccg ctggttcctc atcctgccca 9360 gcttccgtgg tgctggctgc cgctgctgct caagccgccg ctgcttcaca gtccccccca 9420 aaggatatgg tggacctgaa ccgtcgtatc ttcgtggctg ctctgaacaa gctcgagtaa 9480 taaaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt 9540 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 9600 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 9660 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 9720 atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc 9780 taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactatcata 9840 acccctaggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc 9900 cggatctgaa caggagggac agctgataga aacagaagcc actggagcac ctcaaaaaca 9960 ccatcataca ctaaatcagt aagttggcag catcacccga cgcactttgc gccgaataaa 10020 tacctgtgac ggaagatcac ttcgcagaat aaataaatcc tggtgtccct gttgataccg 10080 ggaagccctg ggccaacttt tggcgaaaat gagacgttga tcggcacgta agaggttcca 10140 actttcacca taatgaaata agatcactac cgggcgtatt ttttgagtta tcgagatttt 10200 caggagctaa ggaagctaaa atggagaaaa aaatcactgg atataccacc gttgatatat 10260 cccaatggca tcgtaaagaa cattttgagg catttcagtc agttgctcaa tgtacctata 10320 accagaccgt tcagctggat attacggcct ttttaaagac cgtaaagaaa aataagcaca 10380 agttttatcc ggcctttatt cacattcttg cccgcctgat gaatgctcat ccggaattcc 10440 gtatggcaat gaaagacggt gagctggtga tatgggatag tgttcaccct tgttacaccg 10500 ttttccatga gcaaactgaa acgttttcat cgctctggag tgaataccac gacgatttcc 10560 ggcagtttct acacatatat tcgcaagatg tggcgtgtta cggtgaaaac ctggcctatt 10620 tccctaaagg gtttattgag aatatgtttt tcgtctcagc caatccctgg gtgagtttca 10680 ccagttttga tttaaacgtg gccaatatgg acaacttctt cgcccccgtt ttcaccatgg 10740 gcaaatatta tacgcaaggc gacaaggtgc tgatgccgct ggcgattcag gttcatcatg 10800 ccgtttgtga tggcttccat gtcggcagaa tgcttaatga attacaacag tactgcgatg 10860 agtggcaggg cggggcgtaa tttttttaag gcagttattg gtgcccttaa acgcctggtt 10920 gctacgcctg aataagtgat aataagcgga tgaatggcag aaattcgaaa gcaaattcga 10980 cccggtcgtc ggttcagggc agggtcgtta aatagccgct tatgtctatt gctggtttac 11040 cggtttattg actaccggaa gcagtgtgac cgtgtgcttc tcaaatgcct gaggccagtt 11100 tgctcaggct ctccccgtgg aggtaataat tgacgatatg atcatttatt ctgcctccca 11160 gctgacattc atccggggtc agcaccgttt ctgcggactg gctttctacg tgttccgctt 11220 cctttagcag cccttgcgcc ctgagtgctt gcggcagcgt gaagctaatt ctgtcagccg 11280 ttaagtgttc ctgtgtcact caaaattgct ttgagaggct ctaagggctt ctcagtgcgt 11340 tacatccctg gcttgttgtc cacaaccgtt aaaccttaaa agctttaaaa gccttatata 11400 ttcttttttt tcttataaaa cttaaaacct tagaggctat ttaagttgct gatttatatt 11460 aattttattg ttcaaacatg agagcttagt acgtgaaaca tgagagctta gtacgttagc 11520 catgagagct tagtacgtta gccatgaggg tttagttcgt taaacatgag agcttagtac 11580 gttaaacatg agagcttagt acgtgaaaca tgagagctta gtacgtacta tcaacaggtt 11640 gaactgctga tcaacagatc ctctacgcgg ccgcggtacc ataacttcgt atagcataca 11700 ttatacgaag ttatctggtt taaacgtacc cgtagtggct atggcagggc ttgccgcccc 11760 gacgttggct gcgagccctg ggccttcacc cgaacttggg ggttggggtg gggaaaagga 11820 agaaacgcgg gcgtattggt cccaatgggg tctcggtggg gtatcgacag agtgccagcc 11880 ctgggaccga accccgcgtt tatgaacaaa cgacccaaca cccgtgcgtt ttattctgtc 11940 tttttattgc cgtcatagcg cgggttcctt ccggtattgt ctccttccgt gtttcagtta 12000 gcctccccca tctcccggta ccgcatgcta tgcatcagct gctagcttag cgagcgtcca 12060 cagcctgggg accgtaacgg gagtgagcgg gcaggttcac acgggtctgc ttcagctcag 12120 ggggcaggcc agcgtagtac ttgtccaggt gacgcagcag gggggggtcc agctggtgac 12180 gcaggcagaa ttccttcaca gcgttgtaca ggccgtagaa cagggtgata ccctcgggag 12240 cagcagcggt ggacacgggc agacgcacag cacggttggt acgggtagcc tcgttacgga 12300 tagccaccac cacgttgaac agggaggggg gcaccagctc gaaacccagc acgtgttcgg 12360 tgaagatgga acgaccgtag gacagacgag tcaggtcgta accacggcac aggtcgtcca 12420 cgcaagtgta cacagcgggg gaaccgtcgc cgcactcgga gtaaccgcgc atcacggtca 12480 tccaacgggg agcggtgtcg gaggacagca gggtcagcag agcacgcagc tggtcggggt 12540 tgttgtacag cagggccagg gtgtccagga aagcgtcgtc cagcagcacg gagttagcag 12600 cctcgggggt cacgggacgg taacggatca gctgggacag gggaccgtcc ctacgggtca 12660 cgttgaccag gggacgcagc caggactcgt acttgtcgcc ctggaacacc tctcccagca 12720 ggcaacgacg ggtcagctcg gggcactcag cgggcacctt ctcagccacg gtgggagcca 12780 cggacacggt agcggaggac acgatgggca gcagcaggca gcaccacagc agagccacgg 12840 gaccggggga gaaggagaaa ccgcagtcgg gacgacggca catggtggct cgagatcccg 12900 ggtgatcaag tcttcgtcga gtgattgtaa ataaaatgta atttacagta tagtatttta 12960 attaatatac aaatgatttg ataataattc ttatttaact ataatatatt gtgttgggtt 13020 gaattaaagg tccgtatact agtatcgatt cgcgacctac tccggaatat taatagatca 13080 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 13140 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 13200 gcgcggatcc gccaccatga actccaagga cctgaccccc ttcctgacca ccctgtggct 13260 gctgctggac cactcccgtg tgcctcgtgt gcgtgctgag gaatgctgcg aagtgatcaa 13320 cgtgaaccac ccccccgagc gctgctacga cttcaagatg tgcaacctgt tcaccgtggc 13380 tctgcgttgc cccgacggcg aagtgtgcta ctcccccgaa aagaccgctg agatccgtgg 13440 tatcgtgacc accatgaccc actccctgac ccgtcaagtg atccacaaca agctgaccag 13500 ctgcaactac aaccccctgt acctcgaggc tgacggtcgt atccgttgcg gcaaggtgtc 13560 cgacaaggct cagtacctgc tgggtgctgc tggttccgtg ccctaccgtt ggatcaacct 13620 cgagtacgac aagatcaccc gtatcgtggg cctggaccag tacctcgagt ccgtgaagaa 13680 gcacaagcgt ctggacgtgt gccgtgctaa gatgggttac atgctgcagt aaaagcttgt 13740 cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt 13800 aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt 13860 taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 13920 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 13980 ttatcatgtc tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc 14040 gaaaggaagc tgagttggct gctgtggcta gctttgttta actttaagaa ggagatacat 14100 ctagaccgga atattaatag atcatggaga taattaaaat gataaccatc tcgcaaataa 14160 ataagtattt tactgttttc gtaacagttt tgtaataaaa aaacctataa atattccgga 14220 ttattcatac cgtcccacca tcgggcgcgg atccgccacc atgctgcgtc tgctgctgcg 14280 tcaccacttc cactgcctgc tgctgtgcgc tgtgtgggct accccctgcc tggcttcccc 14340 ctggttcacc ctgaccgcta accagaaccc ctccccaccc tggtccaagc tgacctaccc 14400 caagccccac gacgctgcta ccttctactg ccccttcctg tacccatccc cacctcgttc 14460 cccatcccag ttctccggtt tccagcgtgt gtccaccggt cccgagtgcc gtaacgagac 14520 tctgtacctg ctgtacaacc gcgagggcca gaccctggtc gagaggtcct ccacctgggt 14580 caagaaggtc atctggtact tgtccggtcg taaccagacc atcctgcagc gtatgccccg 14640 taccgcttcc aagccctccg acggcaacgt gcagatctcc gtcgaggacg ctaagatctt 14700 cggtgctcac atggtgccca agcagaccaa gctgctgcgt ttcgtggtca acgacggcac 14760 ccgttaccag atgtgcgtga tgaagctgga atcctgggct cacgtgttcc gtgactactc 14820 cgtgtccttc caagtgcgcc tgaccttcac cgaggctaac aaccagacct acaccttctg 14880 cacccacccc aacctgatcg tgtaagtcga caagcttgtc gagaagtact agaggatcat 14940 aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc 15000 cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta 15060 taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact 15120 gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc 15180 actgcttgag cctagaagat ccggctgcta acaaagcccg aaaggaagct gagttggctg 15240 ctgggtgcct aatgagtgag ctaactcaca ttaattgccc ggaatattaa tagatcatgg 15300 agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag 15360 ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg 15420 cggatccgcc accggatccg ccaccatgcg tctgtgccgt gtgtggctgt ccgtgtgcct 15480 gtgcgctgtg gtgctgggac agtgccagcg tgaaaccgct gagaagaacg actactaccg 15540 tgtgccccac tactgggacg cttgctcccg tgctctgccc gaccagaccc gttacaagta 15600 cgtcgagcag ctggtggacc tgaccctgaa ctaccactac gacgcttccc acggcctgga 15660 caacttcgac gtgctgaagc gtatcaacgt gaccgaggtg tccctgctga tctccgactt 15720 ccgtcgtcag aaccgtcgtg gtggcaccaa caagcgtacc accttcaacg ctgctggttc 15780 cctggctccc cacgctcgtt ccttggagtt ctccgtgcgt ctgttcgcca actaataaaa 15840 gcttgtcgag aagtactaga ggatcataat cagccatacc acatttgtag aggttttact 15900 tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt 15960 tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa 16020 tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa 16080 tgtatcttat catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca 16140 aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta tcataacccc 16200 cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa ataaataagt 16260 attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc cggattattc 16320 ataccgtccc accatcgggc gcggatcccg gtccgaagcg cgcggaattc aaaggcctac 16380 cgtcgacgcc accatggaat cccgtatctg gtgcctggtc gtgtgcgtga acctgtgcat 16440 cgtgtgcctg ggtgctgctg tgtcctcctc ctccacccgt ggcacctccg ctacccactc 16500 ccaccactcc tcccacacca cctccgccgc tcactcccgt tccggttccg tgtcccagcg 16560 tgtgacctcc tcccagaccg tgtcccacgg tgtcaacgag actatctaca acaccaccct 16620 gaagtacggc gacgtcgtgg gtgtcaacac caccaagtac ccctaccgtg tgtgctccat 16680 ggctcagggc accgacctga tccgtttcga gcgtaacatc gtgtgcacct ccatgaagcc 16740 catcaacgag gacctggacg agggtatcat ggtggtgtac aagcgcaaca tcgtggctca 16800 caccttcaag gtccgcgtgt accagaaggt gctgaccttc cgtcgttcct acgcttacat 16860 ccacaccact tacctgctgg gttccaacac cgagtacgtg gcccctccca tgtgggagat 16920 ccaccacatc aactcccact cccagtgcta ctcctcttac tcccgtgtga tcgctggcac 16980 cgtgttcgtg gcttaccacc gtgactccta cgagaacaag accatgcagc tgatgcccga 17040 cgactactcc aacacccact ccacccgtta cgtgaccgtg aaggaccagt ggcactcccg 17100 tggttccacc tggctgtacc gtgaaacctg caacctgaac tgcatggtca ccatcaccac 17160 cgctcgttcc aagtaccctt accacttctt cgctacctcc accggcgacg tggtggacat 17220 ctcccccttc tacaacggta ctaaccgtaa cgcttcctac ttcggcgaga acgctgacaa 17280 gttcttcatc ttccccaact acaccatcgt gtccgacttc ggtcgtccca actccgctct 17340 ggaaacccac cgtctggtgg ctttcttgga gcgtgctgac tccgtgatct cctgggacat 17400 ccaggacgag aagaacgtga cctgccagct gaccttctgg gaggcttccg agcgtaccat 17460 ccgttccgag gctgaggact cctaccactt ctccagcgct aagatgaccg ctaccttcct 17520 gtccaagaaa caagaggtca acatgtccga ctccgccctg gactgcgtgc gtgacgaggc 17580 tatcaacaag ctgcagcaga tcttcaacac ctcctacaac cagacctacg agaagtacgg 17640 aaacgtgtcc gtgttcgaga ctaccggtgg cctggtggtg ttctggcagg gtatcaagca 17700 gaagtccctg gtcgagctgg aacgtctggc taaccgttcc tccctgaacc tgacccacaa 17760 ccgtaccaag cgttccaccg acggcaacaa cgctactcac ctgtccaaca tggaatccgt 17820 gcacaacctg gtgtacgctc agctgcagtt cacctacgac accctgcgcg gttacatcaa 17880 ccgtgctctg gctcagatcg ctgaggcttg gtgcgtggac cagcgtcgta ccctggaagt 17940 gttcaaggaa ctgtccaaga tcaacccctc cgctatcctg tccgccatct acaacaagcc 18000 tatcgctgct cgtttcatgg gcgacgtgct gggcctggct tcctgcgtga ccatcaacca 18060 gacttccgtg aaggtgctgc gtgacatgaa cgtgaaggaa tcccccggtc gttgctactc 18120 ccgtcccgtg gtcatcttca acttcgctaa ctcctcctac gtgcagtacg gccagctggg 18180 cgaggacaac gagatcctgc tgggcaacca ccgtaccgag gaatgccagc tgccctccct 18240 gaagatcttc atcgctggca actccgctta cgaatacgtg gactacctgt tcaagcgcat 18300 gatcgacctg tcctccatct ctaccgtgga ctccatgatc gctctggaca tcgaccccct 18360 ggaaaacacc gacttccgtg tgctggaact gtactcccag aaggaactgc gttccatcaa 18420 cgtgttcgac ctggaagaga tcatgcgcga gttcaactcc tacaagcagc gtgttaagta 18480 cgtcgaggac aaggtggtgg accccctgcc cccctacctg aagggactgg acgacctgat 18540 gtccggcctg ggagctgccg gcaaggctgt gggtgtcgct atcggtgctg tgggtggtgc 18600 tgtggcttcc gtggtcgagg gtgtcgccac cttcctgaag aaccccttcg gtgctttcac 18660 catcatcctg gtggctatcg ctgtggtcat catcatctac ctgatctaca cccgtcagcg 18720 tcgtctgtgc atgcagcccc tgcagaacct gttcccctac ctggtgtccg ctgacggtac 18780 taccgtgacc tccggcaaca ccaaggacac ctccctgcag gctcccccat cctacgagga 18840 atccgtctac aactccggtc gcaagggtcc cggtccccct tcctccgacg cttctaccgc 18900 tgctccccca tacaccaacg agcaggctta ccagatgctg ctggctctcg tgcgtctgga 18960 cgctgagcag cgtgcacagc agaacggcac cgactccctg gacggccaga ccggaaccca 19020 ggacaagggc cagaagccca acctgctgga ccgtctgcgt caccgcaaga acggttaccg 19080 tcacctgaag gactccgacg aggaagagaa cgtctaaggc gcgccaagct tgtcgagaag 19140 tactagagat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc 19200 tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt 19260 ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag 19320 catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg 19380 tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa 19440 gctgggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 19500 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 19560 ttcataccgt cccaccatcg ggcgcggatc cgccaccatg cgtcccggcc tgccctccta 19620 cctgatcgtg ctggctgtgt gcctgctgtc ccacctcctg tcctcccgtt acggtgctga 19680 ggctatctcc gagcccctgg acaaggcttt ccacctcctg ctgaacacct acggtcgtcc 19740 tatccgtttc ctgcgcgaga acaccaccca gtgcacctac aactcctccc tgcgcaactc 19800 caccgtcgtc cgcgagaacg ctatctcctt caacttcttc cagtcctaca accagtacta 19860 cgtgttccac atgccccgtt gcctgttcgc tggtcccctg gctgagcagt tcctgaacca 19920 ggtggacctg accgagactc tcgagcgtta ccagcagcgt ctgaacactt acgctctggt 19980 gtccaaggac ctggcttcct accgttcctt cagccagcag ctgaaggctc aggactccct 20040 gggcgagcag cccaccactg tgcctccccc tatcgacctg tccatccccc acgtgtggat 20100 gcccccccag accactcctc acggctggac cgagtcccac accacctccg gactgcaccg 20160 tccccacttc aaccagacct gcatcctgtt cgacggtcac gacctgctgt tctccaccgt 20220 gaccccctgc ctgcaccagg gcttctacct catcgacgag ctgcgttacg tgaagatcac 20280 cctgaccgag gatttcttcg tggtcaccgt gtccatcgac gacgacaccc ccatgctgct 20340 gatcttcggt cacctccccc gtgtgctgtt caaggctccc taccagcgtg acaacttcat 20400 cctgcgtcag accgagaagc acgagctgct ggtgctggtc aagaaggacc agctgaaccg 20460 tcactcttac ctgaaggacc ccgacttcct ggacgctgct ctggacttca actacctgga 20520 cctgtccgct ctgctgagga actccttcca ccgttacgct gtggacgtgc tgaagtccgg 20580 tcgttgccag atgctggacc gtcgtaccgt cgagatggct ttcgcttacg ccctggctct 20640 gttcgctgct gctcgtcaag aagaggctgg cgctcaggtg tccgtgcccc gtgctctgga 20700 ccgtcaggct gctctgctgc agatccaaga gttcatgatc acttgcctgt cccagacccc 20760 ccctcgtacc accctgctgc tgtaccccac cgctgtggac ctggctaagc gtgctctgtg 20820 gacccccaac cagatcaccg acatcacctc cctcgtgcgt ctggtgtaca tcctgtccaa 20880 gcagaaccag cagcacctga tcccccagtg ggctctgcgt cagatcgctg acttcgctct 20940 gaagctgcac aagacccacc tggcttcatt cctcagcgct ttcgctcgcc aagagctgta 21000 cctgatgggt tccctggtgc actccatgct ggtgcacacc accgagcgtc gcgagatctt 21060 catcgtggaa accggcctgt gctccctggc cgagctgtcc cacttcaccc agctgctggc 21120 tcacccccac cacgagtacc tgtccgacct gtacaccccc tgctcctctt ccggtcgtcg 21180 tgaccactcc ctggaacgtc tgacccgtct gttccccgac gctaccgtgc ctaccaccgt 21240 gcctgctgct ctgtccatcc tgtctaccat gcagccctcc accctggaaa ccttccccga 21300 cctgttctgc ctgcctctgg gcgagtcctt ctccgctctg accgtgtccg agcacgtgtc 21360 ctacgtggtc accaaccagt acctgatcaa gggcatctcc taccccgtgt ccaccaccgt 21420 cgtgggccag tccctgatca tcacccagac cgactcccag accaagtgcg agctgacccg 21480 taacatgcac accactcact ccatcaccgc tgctctgaac atctccctcg agaactgcgc 21540 tttctgccag tccgctctgt tggagtacga cgacactcag ggtgtcatca acatcatgta 21600 catgcacgac tccgacgacg tgctgttcgc tctggacccc tacaacgagg tggtggtgtc 21660 ctccccccgt acccactacc tgatgctgct gaagaacggc accgtgctgg aagtgaccga 21720 cgtggtggtg gacgctaccg accgtctgct gatgatgtcc gtgtacgctc tgtccgctat 21780 catcggcatc tacctgctgt accgtatgct gaagacctgc taaggcgcca agctttgtcg 21840 agaagtacta gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa 21900 aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta 21960 acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa 22020 ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt 22080 atcatgtctg gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga 22140 aaggaagctg agttggctgc tgccaccgct gagcaataac tatcataacc cctaggagat 22200 ccgaaccaga taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta 22260 gcttacgacg ctacacccag ttcccatcta ttttgtcact cttccctaaa taatccttaa 22320 aaactccatt tccacccctc ccagttccca actattttgt ccgcccaca 22369 <210> 42 <211> 25991 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 42 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgtggctagc tttgtttaac tttaagaagg agatacatct agaccggaat attaatagat 7200 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 7260 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 7320 gggcgcggat cccggtccga agcgcgcgga attcaaaggc ctacgtcgac gccaccatgg 7380 aatcccgtgg tcgtcgttgc cccgagatga tctccgtgct gggtcccatc tccggtcacg 7440 tcctgaaggc tgtgttctcc cgtggcgaca cccccgtgct gccccacgaa actcgtctgc 7500 tgcagaccgg tatccacgtg cgtgtgtccc agccctccct gatcctggtg tcccagtaca 7560 cccccgactc caccccttgc caccgcggag acaaccagct gcaggtccag cacacctact 7620 tcaccggttc cgaggtcgag aacgtgtccg tgaacgtgca caaccccacc ggtcgttcca 7680 tctgcccctc ccaagagccc atgtccatct acgtgtacgc tctgcccctg aagatgctga 7740 acatcccctc catcaacgtg caccactacc cctccgctgc tgagcgcaag caccgtcacc 7800 tccccgtggc tgacgctgtg atccacgctt ccggcaagca gatgtggcag gctcgtctga 7860 ccgtgtccgg cctggcttgg acccgtcagc agaaccagtg gaaggaaccc gacgtgtact 7920 acacctccgc tttcgtgttc cccaccaagg acgtggccct gcgtcacgtc gtgtgcgctc 7980 acgaactcgt gtgctccatg gaaaacaccc gtgctaccaa gatgcaagtg atcggcgacc 8040 agtacgtgaa ggtgtacctg gaatccttct gcgaggacgt gccctccggc aagctgttca 8100 tgcacgtgac cctgggttcc gacgtggaag aggacctgac catgacccgt aacccccagc 8160 ccttcatgcg tccccacgag cgtaacggtt tcaccgtgct gtgccccaag aacatgatca 8220 tcaagcccgg caagatctcc cacatcatgc tggacgtggc cttcacctcc cacgagcact 8280 tcggcctgct gtgccctaag tccatccccg gcctgtccat ctccggcaac ctgctgatga 8340 acggccagca gatcttcctg gaagtgcagg ctatccgtga aaccgtcgag ctgcgtcagt 8400 acgaccctgt ggctgctctg ttcttcttcg acatcgacct gctgctgcag cgtggtcccc 8460 agtactccga gcaccccacc ttcaccagcc agtaccgtat ccagggcaag ctggaatacc 8520 gtcacacctg ggaccgtcac gacgagggtg ctgctcaggg cgacgacgac gtgtggacct 8580 ccggttccga ctccgacgag gaactggtca ccaccgagcg caagaccccc cgtgtgaccg 8640 gtggtggtgc tatggctggt gcttccacct ccgctggtcg caagcgcaag tccgcttcct 8700 ccgctaccgc ttgcaccgct ggtgtcatga cccgtggtcg cctgaaggct gagtccaccg 8760 tggctcccga agaggacact gacgaggact ccgacaacga gatccacaac cccgctgtgt 8820 tcacctggcc cccctggcag gctggtatcc tggctcgtaa cctggtgccc atggtggcta 8880 ccgtgcaggg ccagaacctg aagtaccaag agttcttctg ggacgccaac gacatctacc 8940 gtatcttcgc tgagctggaa ggcgtgtggc agcccgctgc tcagcccaag cgtcgtcgtc 9000 accgtcagga cgctctgcct ggtccctgta tcgcttccac ccccaagaag caccgcggct 9060 aaaagcttgt cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt 9120 tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa 9180 ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca 9240 caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca 9300 tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga tccggctgct 9360 aacaaagccc gaaaggaagc tgagttggct gctgccaccg ctgagcaata actatcataa 9420 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 9480 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 9540 cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt cgccaccatg 9600 accatggacg agcagcagcc ccaggctgtg acccccgtgt acgtgggcgg tttcctggct 9660 cgttacgacc agtcccccga cgaggctgag ctgctgctgc cacgtgacgt ggtcgaacac 9720 tggctgcacg ctcagggcca gggacagcct tccctgtccg tggctctgcc cctgaacatc 9780 aaccacgacg acaccgctgt cgtgggtcac gtggccgcta tgcagtccgt gcgtgacggc 9840 ctgttctgcc tgggttgcgt gacctccccc cgtttcctgg aaatcgtgcg tcgtgcttcc 9900 gagaagtccg agctggtgtc ccgtggtccc gtgtccccac tgcagcccga caaggtggtc 9960 gagttcctgt ccggttccta cgctggcctg tccctgtcat cccgtcgttg cgacgacgtc 10020 gaggctgcta cctccctgag cggctccgag actaccccct tcaagcacgt ggccctgtgc 10080 tccgtgggtc gtaggcgtgg aaccctggct gtgtacggtc gtgaccccga gtgggtcacc 10140 cagcgtttcc ccgacctgac cgctgctgac cgtgacggac tgcgtgctca gtggcagcgt 10200 tgcggttcca ccgctgtgga cgcttccggc gaccccttcc gttccgactc ctacggcctg 10260 ctgggcaact ccgtggacgc tctgtacatc cgcgagcgtc tgcccaagct gcgttacgac 10320 aagcagctcg tgggtgtcac cgagcgcgag tcctacgtga aggcttccgt gtcccccgag 10380 gctgcttgcg acatcaaggc tgcttccgct gagcgttctg gcgacagccg ctcccaggct 10440 gctactcctg ctgctggtgc tcgtgtgccc tccagctccc catccccacc tgtcgagcct 10500 ccctcccccg tgcaacctcc tgctctgcct gcttccccct ccgtgctgcc tgctgagtcc 10560 agcccctccc tgtcaccctc tgagcctgct gaggctgcct ccatgtccca ccctctgagc 10620 gctgctgtga ctgctgctac cgctccccct ggtgctactg tggctggtgc ttcccccgct 10680 gtgccttccc tggcttggcc tcacgacggt gtctacctgc ccaaggacgc tttcttctcc 10740 ctgctgggcg cttcccgttc cgctgctccc gtgatgtacc ccggtgctgt ggctgctccc 10800 cccagcgctt cacctgctcc tctgcccctg ccctcctacc ccgcttccta cggtgctccc 10860 gtcgtgggtt acgaccagct ggctgctcgt cacttcgctg actacgtgga cccccactac 10920 cccggctggg gtcgtcgtta cgagcccgct ccttccctgc acccatccta ccctgtgccc 10980 cctcctccat cacccgctta ctaccgtcgt cgtgactccc ccggtggcat ggacgagcct 11040 ccatctggat gggagcgtta cgacggttcc caccgtggcc agtcccaaaa gcagcaccgt 11100 cacggtggtt ccggtggtca caacaagcgt cgcaaggaag ccgctgctgc atcctccagc 11160 tccgacgagg acctgagctt ccccggcgag gctgaacacg gtcgtgctcg caagcgtctg 11220 aagtcccacg tgaactccga cggaggtagc ggaggccacg ctggttccaa ccagcagcag 11280 caacagcgct acgacgagct gcgtgacgct atccacgagc tgaagcgtga cctgttcgct 11340 gctcgccagt cctccaccct gctgtctgct gctctgccag ctgccgcttc ttcctcccct 11400 accaccacca ccgtgtgcac ccctactggc gagctgacct ctggtggtgg cgagactccc 11460 accgctctgc tgtccggtgg tgctaaggtg gccgagcgtg ctcaggctgg tgtcgtgaac 11520 gcttcctgcc gtctggctac cgcttccggt tccgaggctg ccaccgctgg tccctctacc 11580 gctggttcct catcctgccc agcttccgtg gtgctggctg ccgctgctgc tcaagccgcc 11640 gctgcttcac agtccccccc aaaggatatg gtggacctga accgtcgtat cttcgtggct 11700 gctctgaaca agctcgagta ataaaagctt gtcgagaagt actagaggat cataatcagc 11760 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 11820 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 11880 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 11940 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 12000 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgggaata ttaatagatc 12060 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 12120 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 12180 ggcgcggatc cgccaccatg gctgctatgg aagctaacat cttctgcacc ttcgaccaca 12240 agctgtctat cgctgacgtg ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc 12300 cccagcgtct gcacctgatc aagcactacc agctgggcct gcaccagttc gtggaccaca 12360 cccgtggtta cgtgcgtctg cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc 12420 gtgtcgaggg caaccagatc ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc 12480 tgaacaccgg tcccgtgacc tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt 12540 tccacggtcc cctggctcgt gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc 12600 cctggatcgt gcccatgccc ctggctctgg aaatcaacca gcgcctgctg atcatgggcc 12660 tgttctccct ggaccgttcc tacgaagaag tgaaggctgc tgtccagcag ctgcagacca 12720 tcaccttccg tgacgctacc ttcaccatcc ccgaccccgt gatcgaccag cacctcctga 12780 tcgacatgaa gaccgcttgc ctgtccatgt ccatggtggc taacctggct tccgagctga 12840 ccatgaccta cgtccgcaag ctggctttgg aggactcttc catgctgctg gtcaagtgcc 12900 aagagctgct gatgcgtctg gaccgcgagc gttccgtggg cgagcctcgt actcccgctc 12960 gtcctcagca cgtgtccccc gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc 13020 tgcgtcagct ggacgacctg atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc 13080 cagacaacaa gtccgctacc tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa 13140 gtactagagg atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa 13200 cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt 13260 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 13320 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 13380 tgtctggatc tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg 13440 aagctgagtt ggctgctgcc accgctgagc aataactatc ataaccccta ggggcctcta 13500 aacgggtctt gaggggtttt ttgctgaaag gaggaactat atccggatct gaacaggagg 13560 gacagctgat agaaacagaa gccactggag cacctcaaaa acaccatcat acactaaatc 13620 agtaagttgg cagcatcacc cgacgcactt tgcgccgaat aaatacctgt gacggaagat 13680 cacttcgcag aataaataaa tcctggtgtc cctgttgata ccgggaagcc ctgggccaac 13740 ttttggcgaa aatgagacgt tgatcggcac gtaagaggtt ccaactttca ccataatgaa 13800 ataagatcac taccgggcgt attttttgag ttatcgagat tttcaggagc taaggaagct 13860 aaaatggaga aaaaaatcac tggatatacc accgttgata tatcccaatg gcatcgtaaa 13920 gaacattttg aggcatttca gtcagttgct caatgtacct ataaccagac cgttcagctg 13980 gatattacgg cctttttaaa gaccgtaaag aaaaataagc acaagtttta tccggccttt 14040 attcacattc ttgcccgcct gatgaatgct catccggaat tccgtatggc aatgaaagac 14100 ggtgagctgg tgatatggga tagtgttcac ccttgttaca ccgttttcca tgagcaaact 14160 gaaacgtttt catcgctctg gagtgaatac cacgacgatt tccggcagtt tctacacata 14220 tattcgcaag atgtggcgtg ttacggtgaa aacctggcct atttccctaa agggtttatt 14280 gagaatatgt ttttcgtctc agccaatccc tgggtgagtt tcaccagttt tgatttaaac 14340 gtggccaata tggacaactt cttcgccccc gttttcacca tgggcaaata ttatacgcaa 14400 ggcgacaagg tgctgatgcc gctggcgatt caggttcatc atgccgtttg tgatggcttc 14460 catgtcggca gaatgcttaa tgaattacaa cagtactgcg atgagtggca gggcggggcg 14520 taattttttt aaggcagtta ttggtgccct taaacgcctg gttgctacgc ctgaataagt 14580 gataataagc ggatgaatgg cagaaattcg aaagcaaatt cgacccggtc gtcggttcag 14640 ggcagggtcg ttaaatagcc gcttatgtct attgctggtt taccggttta ttgactaccg 14700 gaagcagtgt gaccgtgtgc ttctcaaatg cctgaggcca gtttgctcag gctctccccg 14760 tggaggtaat aattgacgat atgatcattt attctgcctc ccagctgaca ttcatccggg 14820 gtcagcaccg tttctgcgga ctggctttct acgtgttccg cttcctttag cagcccttgc 14880 gccctgagtg cttgcggcag cgtgaagcta attctgtcag ccgttaagtg ttcctgtgtc 14940 actcaaaatt gctttgagag gctctaaggg cttctcagtg cgttacatcc ctggcttgtt 15000 gtccacaacc gttaaacctt aaaagcttta aaagccttat atattctttt ttttcttata 15060 aaacttaaaa ccttagaggc tatttaagtt gctgatttat attaatttta ttgttcaaac 15120 atgagagctt agtacgtgaa acatgagagc ttagtacgtt agccatgaga gcttagtacg 15180 ttagccatga gggtttagtt cgttaaacat gagagcttag tacgttaaac atgagagctt 15240 agtacgtgaa acatgagagc ttagtacgta ctatcaacag gttgaactgc tgatcaacag 15300 atcctctacg cggccgcggt accataactt cgtatagcat acattatacg aagttatctg 15360 gtttaaacgt acccgtagtg gctatggcag ggcttgccgc cccgacgttg gctgcgagcc 15420 ctgggccttc acccgaactt gggggttggg gtggggaaaa ggaagaaacg cgggcgtatt 15480 ggtcccaatg gggtctcggt ggggtatcga cagagtgcca gccctgggac cgaaccccgc 15540 gtttatgaac aaacgaccca acacccgtgc gttttattct gtctttttat tgccgtcata 15600 gcgcgggttc cttccggtat tgtctccttc cgtgtttcag ttagcctccc ccatctcccg 15660 gtaccgcatg ctatgcatca gctgctagct tagcgagcgt ccacagcctg gggaccgtaa 15720 cgggagtgag cgggcaggtt cacacgggtc tgcttcagct cagggggcag gccagcgtag 15780 tacttgtcca ggtgacgcag cagggggggg tccagctggt gacgcaggca gaattccttc 15840 acagcgttgt acaggccgta gaacagggtg ataccctcgg gagcagcagc ggtggacacg 15900 ggcagacgca cagcacggtt ggtacgggta gcctcgttac ggatagccac caccacgttg 15960 aacagggagg ggggcaccag ctcgaaaccc agcacgtgtt cggtgaagat ggaacgaccg 16020 taggacagac gagtcaggtc gtaaccacgg cacaggtcgt ccacgcaagt gtacacagcg 16080 ggggaaccgt cgccgcactc ggagtaaccg cgcatcacgg tcatccaacg gggagcggtg 16140 tcggaggaca gcagggtcag cagagcacgc agctggtcgg ggttgttgta cagcagggcc 16200 agggtgtcca ggaaagcgtc gtccagcagc acggagttag cagcctcggg ggtcacggga 16260 cggtaacgga tcagctggga caggggaccg tccctacggg tcacgttgac caggggacgc 16320 agccaggact cgtacttgtc gccctggaac acctctccca gcaggcaacg acgggtcagc 16380 tcggggcact cagcgggcac cttctcagcc acggtgggag ccacggacac ggtagcggag 16440 gacacgatgg gcagcagcag gcagcaccac agcagagcca cgggaccggg ggagaaggag 16500 aaaccgcagt cgggacgacg gcacatggtg gctcgagatc ccgggtgatc aagtcttcgt 16560 cgagtgattg taaataaaat gtaatttaca gtatagtatt ttaattaata tacaaatgat 16620 ttgataataa ttcttattta actataatat attgtgttgg gttgaattaa aggtccgtat 16680 actagtatcg attcgcgacc tactccggaa tattaataga tcatggagat aattaaaatg 16740 ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa 16800 aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccacca 16860 tgtcccccaa gaacctgacc cccttcctga ccgctctgtg gctgctgctg ggccactccc 16920 gtgtgcctcg tgtgcgtgct gaggaatgct gcgagttcat caacgtgaac cacccccccg 16980 agcgctgcta cgacttcaag atgtgcaacc gtttcaccgt ggctctgcgt tgccccgacg 17040 gcgaagtgtg ctactccccc gaaaagaccg ctgagatccg tggtatcgtg accaccatga 17100 cccactccct gacccgtcag gtggtgcaca acaagctgac ctcttgcaac tacaaccccc 17160 tgtacctcga ggctgacggt cgtatccgtt gcggcaaggt caacgacaag gctcagtacc 17220 tgctgggtgc tgctggttcc gtgccctacc gttggatcaa cctcgagtac gacaagatca 17280 cccgtatcgt gggcctggac cagtacctcg agtccgtgaa gaagcacaag cgtctggacg 17340 tgtgccgtgc taagatgggt tacatgctgc agtaaaagct tgtcgagaag tactagagga 17400 tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc 17460 tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag 17520 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 17580 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct 17640 gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg 17700 gctgctgtgg ctagctttgt ttaactttaa gaaggagata catctagacc ggaatattaa 17760 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 17820 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 17880 ccatcgggcg cggatccgcc accatgctgc gtctgctgct gcgtcaccac ttccactgcc 17940 tgctgctgtg cgctgtgtgg gctaccccct gcctggcttc cccttggtcc accctgaccg 18000 ctaaccagaa cccctcccca ccctggtcca agctgaccta ctccaagccc cacgacgctg 18060 ctaccttcta ctgccccttc ctgtacccat ccccccctcg ttccccactg cagttctccg 18120 gtttccagcg tgtgctgacc ggtcccgagt gccgtaacga gactctgtac ctgctgtaca 18180 accgcgaggg ccagaccctg gtcgagaggt cctccacctg ggtcaagaag gtcatctggt 18240 acttgtccgg tcgtaaccag accatcctgc agcgtatgcc ccgtaccgct tccaagccct 18300 ccgacggcaa cgtgcagatc tccgtcgagg acgctaagat cttcggtgct cacatggtgc 18360 ccaagcagac caagctgctg cgtttcgtgg tcaacgacgg cacccgttac cagatgtgcg 18420 tgatgaagct cgagtcctgg gctcacgtgt tccgtgacta ctccgtgtcc ttccaagtgc 18480 gcctgacctt caccgaggct aacaaccaga cctacacctt ctgcacccac cccaacctga 18540 tcgtgtaaaa gcttgtcgag aagtactaga ggatcataat cagccatacc acatttgtag 18600 aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga 18660 atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata 18720 gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca 18780 aactcatcaa tgtatcttat catgtctgga tctgatcact gcttgagcct agaagatccg 18840 gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ggtgcctaat gagtgagcta 18900 actcacatta attgcccgga atattaatag atcatggaga taattaaaat gataaccatc 18960 tcgcaaataa ataagtattt tactgttttc gtaacagttt tgtaataaaa aaacctataa 19020 atattccgga ttattcatac cgtcccacca tcgggcgcgg atccgccacc atgcgtctgt 19080 gccgtgtgtg gctgtccgtg tgcctgtgcg ctgtggtgct gggccagtgc cagcgtgaaa 19140 ccgctgagaa gaacgactac taccgtgtgc cccactactg ggacgcttgc tcccgtgctc 19200 tgcccgacca gacccgttac aagtacgtcg agcagctggt ggacctgacc ctgaactacc 19260 actacgacgc ttcccacggc ctggacaact tcgacgtgct gaagcgtatc aacgtgaccg 19320 aggtgtccct gctgatctcc gacttccgtc gtcagaaccg tcgtggtggc accaacaagc 19380 gtaccacctt caacgctgct ggttccctgg ctccccacgc tcgttccctc gagttctccg 19440 tgcgtctgtt cgctaactaa aagcttgtcg agaagtacta gaggatcata atcagccata 19500 ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga 19560 aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca 19620 aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt 19680 gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc 19740 ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct 19800 gagcaataac tatcataacc cccggaatat taatagatca tggagataat taaaatgata 19860 accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac 19920 ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc cggtccgaag 19980 cgcgcggaat tcaaaggcct accgtcgacg ccaccatgga atcccgtatc tggtgcctgg 20040 tcgtgtgcgt gaacctgtgc atcgtgtgcc tgggtgctgc tgtgtcctcc tcctccaccc 20100 gtggcacctc cgctacccac tcccaccact cctcccacac cacctccgcc gctcactccc 20160 gttccggttc cgtgtcccag cgtgtgacct cctcccagac cgtgtcccac ggtgtcaacg 20220 agactatcta caacaccacc ctgaagtacg gcgacgtcgt gggtgtcaac accaccaagt 20280 acccctaccg tgtgtgctcc atggctcagg gcaccgacct gatccgtttc gagcgtaaca 20340 tcgtgtgcac ctccatgaag cccatcaacg aggacctgga cgagggtatc atggtggtgt 20400 acaagcgcaa catcgtggct cacaccttca aggtccgcgt gtaccagaag gtgctgacct 20460 tccgtcgttc ctacgcttac atccacacca cttacctgct gggttccaac accgagtacg 20520 tggcccctcc catgtgggag atccaccaca tcaactccca ctcccagtgc tactcctctt 20580 actcccgtgt gatcgctggc accgtgttcg tggcttacca ccgtgactcc tacgagaaca 20640 agaccatgca gctgatgccc gacgactact ccaacaccca ctccacccgt tacgtgaccg 20700 tgaaggacca gtggcactcc cgtggttcca cctggctgta ccgtgaaacc tgcaacctga 20760 actgcatggt caccatcacc accgctcgtt ccaagtaccc ttaccacttc ttcgctacct 20820 ccaccggcga cgtggtggac atctccccct tctacaacgg tactaaccgt aacgcttcct 20880 acttcggcga gaacgctgac aagttcttca tcttccccaa ctacaccatc gtgtccgact 20940 tcggtcgtcc caactccgct ctggaaaccc accgtctggt ggctttcttg gagcgtgctg 21000 actccgtgat ctcctgggac atccaggacg agaagaacgt gacctgccag ctgaccttct 21060 gggaggcttc cgagcgtacc atccgttccg aggctgagga ctcctaccac ttctccagcg 21120 ctaagatgac cgctaccttc ctgtccaaga aacaagaggt caacatgtcc gactccgccc 21180 tggactgcgt gcgtgacgag gctatcaaca agctgcagca gatcttcaac acctcctaca 21240 accagaccta cgagaagtac ggaaacgtgt ccgtgttcga gactaccggt ggcctggtgg 21300 tgttctggca gggtatcaag cagaagtccc tggtcgagct ggaacgtctg gctaaccgtt 21360 cctccctgaa cctgacccac aaccgtacca agcgttccac cgacggcaac aacgctactc 21420 acctgtccaa catggaatcc gtgcacaacc tggtgtacgc tcagctgcag ttcacctacg 21480 acaccctgcg cggttacatc aaccgtgctc tggctcagat cgctgaggct tggtgcgtgg 21540 accagcgtcg taccctggaa gtgttcaagg aactgtccaa gatcaacccc tccgctatcc 21600 tgtccgccat ctacaacaag cctatcgctg ctcgtttcat gggcgacgtg ctgggcctgg 21660 cttcctgcgt gaccatcaac cagacttccg tgaaggtgct gcgtgacatg aacgtgaagg 21720 aatcccccgg tcgttgctac tcccgtcccg tggtcatctt caacttcgct aactcctcct 21780 acgtgcagta cggccagctg ggcgaggaca acgagatcct gctgggcaac caccgtaccg 21840 aggaatgcca gctgccctcc ctgaagatct tcatcgctgg caactccgct tacgaatacg 21900 tggactacct gttcaagcgc atgatcgacc tgtcctccat ctctaccgtg gactccatga 21960 tcgctctgga catcgacccc ctggaaaaca ccgacttccg tgtgctggaa ctgtactccc 22020 agaaggaact gcgttccatc aacgtgttcg acctggaaga gatcatgcgc gagttcaact 22080 cctacaagca gcgtgttaag tacgtcgagg acaaggtggt ggaccccctg cccccctacc 22140 tgaagggact ggacgacctg atgtccggcc tgggagctgc cggcaaggct gtgggtgtcg 22200 ctatcggtgc tgtgggtggt gctgtggctt ccgtggtcga gggtgtcgcc accttcctga 22260 agaacccctt cggtgctttc accatcatcc tggtggctat cgctgtggtc atcatcatct 22320 acctgatcta cacccgtcag cgtcgtctgt gcatgcagcc cctgcagaac ctgttcccct 22380 acctggtgtc cgctgacggt actaccgtga cctccggcaa caccaaggac acctccctgc 22440 aggctccccc atcctacgag gaatccgtct acaactccgg tcgcaagggt cccggtcccc 22500 cttcctccga cgcttctacc gctgctcccc catacaccaa cgagcaggct taccagatgc 22560 tgctggctct cgtgcgtctg gacgctgagc agcgtgcaca gcagaacggc accgactccc 22620 tggacggcca gaccggaacc caggacaagg gccagaagcc caacctgctg gaccgtctgc 22680 gtcaccgcaa gaacggttac cgtcacctga aggactccga cgaggaagag aacgtctaag 22740 gcgcgccaag cttgtcgaga agtactagag atcataatca gccataccac atttgtagag 22800 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 22860 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 22920 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 22980 ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc 23040 tgctaacaaa gcccgaaagg aagctgggaa tattaataga tcatggagat aattaaaatg 23100 ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa 23160 aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccacca 23220 tgcgtcccgg cctgccctcc tacctgatcg tgctggctgt gtgcctgctg tcccacctcc 23280 tgtcctcccg ttacggtgct gaggctatct ccgagcccct ggacaaggct ttccacctcc 23340 tgctgaacac ctacggtcgt cctatccgtt tcctgcgcga gaacaccacc cagtgcacct 23400 acaactcctc cctgcgcaac tccaccgtcg tccgcgagaa cgctatctcc ttcaacttct 23460 tccagtccta caaccagtac tacgtgttcc acatgccccg ttgcctgttc gctggtcccc 23520 tggctgagca gttcctgaac caggtggacc tgaccgagac tctcgagcgt taccagcagc 23580 gtctgaacac ttacgctctg gtgtccaagg acctggcttc ctaccgttcc ttcagccagc 23640 agctgaaggc tcaggactcc ctgggcgagc agcccaccac tgtgcctccc cctatcgacc 23700 tgtccatccc ccacgtgtgg atgccccccc agaccactcc tcacggctgg accgagtccc 23760 acaccacctc cggactgcac cgtccccact tcaaccagac ctgcatcctg ttcgacggtc 23820 acgacctgct gttctccacc gtgaccccct gcctgcacca gggcttctac ctcatcgacg 23880 agctgcgtta cgtgaagatc accctgaccg aggatttctt cgtggtcacc gtgtccatcg 23940 acgacgacac ccccatgctg ctgatcttcg gtcacctccc ccgtgtgctg ttcaaggctc 24000 cctaccagcg tgacaacttc atcctgcgtc agaccgagaa gcacgagctg ctggtgctgg 24060 tcaagaagga ccagctgaac cgtcactctt acctgaagga ccccgacttc ctggacgctg 24120 ctctggactt caactacctg gacctgtccg ctctgctgag gaactccttc caccgttacg 24180 ctgtggacgt gctgaagtcc ggtcgttgcc agatgctgga ccgtcgtacc gtcgagatgg 24240 ctttcgctta cgccctggct ctgttcgctg ctgctcgtca agaagaggct ggcgctcagg 24300 tgtccgtgcc ccgtgctctg gaccgtcagg ctgctctgct gcagatccaa gagttcatga 24360 tcacttgcct gtcccagacc ccccctcgta ccaccctgct gctgtacccc accgctgtgg 24420 acctggctaa gcgtgctctg tggaccccca accagatcac cgacatcacc tccctcgtgc 24480 gtctggtgta catcctgtcc aagcagaacc agcagcacct gatcccccag tgggctctgc 24540 gtcagatcgc tgacttcgct ctgaagctgc acaagaccca cctggcttca ttcctcagcg 24600 ctttcgctcg ccaagagctg tacctgatgg gttccctggt gcactccatg ctggtgcaca 24660 ccaccgagcg tcgcgagatc ttcatcgtgg aaaccggcct gtgctccctg gccgagctgt 24720 cccacttcac ccagctgctg gctcaccccc accacgagta cctgtccgac ctgtacaccc 24780 cctgctcctc ttccggtcgt cgtgaccact ccctggaacg tctgacccgt ctgttccccg 24840 acgctaccgt gcctaccacc gtgcctgctg ctctgtccat cctgtctacc atgcagccct 24900 ccaccctgga aaccttcccc gacctgttct gcctgcctct gggcgagtcc ttctccgctc 24960 tgaccgtgtc cgagcacgtg tcctacgtgg tcaccaacca gtacctgatc aagggcatct 25020 cctaccccgt gtccaccacc gtcgtgggcc agtccctgat catcacccag accgactccc 25080 agaccaagtg cgagctgacc cgtaacatgc acaccactca ctccatcacc gctgctctga 25140 acatctccct cgagaactgc gctttctgcc agtccgctct gttggagtac gacgacactc 25200 agggtgtcat caacatcatg tacatgcacg actccgacga cgtgctgttc gctctggacc 25260 cctacaacga ggtggtggtg tcctcccccc gtacccacta cctgatgctg ctgaagaacg 25320 gcaccgtgct ggaagtgacc gacgtggtgg tggacgctac cgaccgtctg ctgatgatgt 25380 ccgtgtacgc tctgtccgct atcatcggca tctacctgct gtaccgtatg ctgaagacct 25440 gctaaggcgc caagctttgt cgagaagtac tagaggatca taatcagcca taccacattt 25500 gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa 25560 atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc 25620 aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 25680 tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga 25740 tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgccaccg ctgagcaata 25800 actatcataa cccctaggag atccgaacca gataagtgaa atctagttcc aaactatttt 25860 gtcattttta attttcgtat tagcttacga cgctacaccc agttcccatc tattttgtca 25920 ctcttcccta aataatcctt aaaaactcca tttccacccc tcccagttcc caactatttt 25980 gtccgcccac a 25991 <210> 43 <211> 25991 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 43 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgtggctagc tttgtttaac tttaagaagg agatacatct agaccggaat attaatagat 7200 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 7260 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 7320 gggcgcggat cccggtccga agcgcgcgga attcaaaggc ctacgtcgac gccaccatgg 7380 aatcccgtgg tcgtcgttgc cccgagatga tctccgtgct gggtcccatc tccggtcacg 7440 tcctgaaggc tgtgttctcc cgtggcgaca cccccgtgct gccccacgaa actcgtctgc 7500 tgcagaccgg tatccacgtg cgtgtgtccc agccctccct gatcctggtg tcccagtaca 7560 cccccgactc caccccttgc caccgcggag acaaccagct gcaggtccag cacacctact 7620 tcaccggttc cgaggtcgag aacgtgtccg tgaacgtgca caaccccacc ggtcgttcca 7680 tctgcccctc ccaagagccc atgtccatct acgtgtacgc tctgcccctg aagatgctga 7740 acatcccctc catcaacgtg caccactacc cctccgctgc tgagcgcaag caccgtcacc 7800 tccccgtggc tgacgctgtg atccacgctt ccggcaagca gatgtggcag gctcgtctga 7860 ccgtgtccgg cctggcttgg acccgtcagc agaaccagtg gaaggaaccc gacgtgtact 7920 acacctccgc tttcgtgttc cccaccaagg acgtggccct gcgtcacgtc gtgtgcgctc 7980 acgaactcgt gtgctccatg gaaaacaccc gtgctaccaa gatgcaagtg atcggcgacc 8040 agtacgtgaa ggtgtacctg gaatccttct gcgaggacgt gccctccggc aagctgttca 8100 tgcacgtgac cctgggttcc gacgtggaag aggacctgac catgacccgt aacccccagc 8160 ccttcatgcg tccccacgag cgtaacggtt tcaccgtgct gtgccccaag aacatgatca 8220 tcaagcccgg caagatctcc cacatcatgc tggacgtggc cttcacctcc cacgagcact 8280 tcggcctgct gtgccctaag tccatccccg gcctgtccat ctccggcaac ctgctgatga 8340 acggccagca gatcttcctg gaagtgcagg ctatccgtga aaccgtcgag ctgcgtcagt 8400 acgaccctgt ggctgctctg ttcttcttcg acatcgacct gctgctgcag cgtggtcccc 8460 agtactccga gcaccccacc ttcaccagcc agtaccgtat ccagggcaag ctggaatacc 8520 gtcacacctg ggaccgtcac gacgagggtg ctgctcaggg cgacgacgac gtgtggacct 8580 ccggttccga ctccgacgag gaactggtca ccaccgagcg caagaccccc cgtgtgaccg 8640 gtggtggtgc tatggctggt gcttccacct ccgctggtcg caagcgcaag tccgcttcct 8700 ccgctaccgc ttgcaccgct ggtgtcatga cccgtggtcg cctgaaggct gagtccaccg 8760 tggctcccga agaggacact gacgaggact ccgacaacga gatccacaac cccgctgtgt 8820 tcacctggcc cccctggcag gctggtatcc tggctcgtaa cctggtgccc atggtggcta 8880 ccgtgcaggg ccagaacctg aagtaccaag agttcttctg ggacgccaac gacatctacc 8940 gtatcttcgc tgagctggaa ggcgtgtggc agcccgctgc tcagcccaag cgtcgtcgtc 9000 accgtcagga cgctctgcct ggtccctgta tcgcttccac ccccaagaag caccgcggct 9060 aaaagcttgt cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt 9120 tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa 9180 ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca 9240 caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca 9300 tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga tccggctgct 9360 aacaaagccc gaaaggaagc tgagttggct gctgccaccg ctgagcaata actatcataa 9420 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 9480 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 9540 cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt cgccaccatg 9600 accatggacg agcagcagcc ccaggctgtg acccccgtgt acgtgggcgg tttcctggct 9660 cgttacgacc agtcccccga cgaggctgag ctgctgctgc cacgtgacgt ggtcgaacac 9720 tggctgcacg ctcagggcca gggacagcct tccctgtccg tggctctgcc cctgaacatc 9780 aaccacgacg acaccgctgt cgtgggtcac gtggccgcta tgcagtccgt gcgtgacggc 9840 ctgttctgcc tgggttgcgt gacctccccc cgtttcctgg aaatcgtgcg tcgtgcttcc 9900 gagaagtccg agctggtgtc ccgtggtccc gtgtccccac tgcagcccga caaggtggtc 9960 gagttcctgt ccggttccta cgctggcctg tccctgtcat cccgtcgttg cgacgacgtc 10020 gaggctgcta cctccctgag cggctccgag actaccccct tcaagcacgt ggccctgtgc 10080 tccgtgggtc gtaggcgtgg aaccctggct gtgtacggtc gtgaccccga gtgggtcacc 10140 cagcgtttcc ccgacctgac cgctgctgac cgtgacggac tgcgtgctca gtggcagcgt 10200 tgcggttcca ccgctgtgga cgcttccggc gaccccttcc gttccgactc ctacggcctg 10260 ctgggcaact ccgtggacgc tctgtacatc cgcgagcgtc tgcccaagct gcgttacgac 10320 aagcagctcg tgggtgtcac cgagcgcgag tcctacgtga aggcttccgt gtcccccgag 10380 gctgcttgcg acatcaaggc tgcttccgct gagcgttctg gcgacagccg ctcccaggct 10440 gctactcctg ctgctggtgc tcgtgtgccc tccagctccc catccccacc tgtcgagcct 10500 ccctcccccg tgcaacctcc tgctctgcct gcttccccct ccgtgctgcc tgctgagtcc 10560 agcccctccc tgtcaccctc tgagcctgct gaggctgcct ccatgtccca ccctctgagc 10620 gctgctgtga ctgctgctac cgctccccct ggtgctactg tggctggtgc ttcccccgct 10680 gtgccttccc tggcttggcc tcacgacggt gtctacctgc ccaaggacgc tttcttctcc 10740 ctgctgggcg cttcccgttc cgctgctccc gtgatgtacc ccggtgctgt ggctgctccc 10800 cccagcgctt cacctgctcc tctgcccctg ccctcctacc ccgcttccta cggtgctccc 10860 gtcgtgggtt acgaccagct ggctgctcgt cacttcgctg actacgtgga cccccactac 10920 cccggctggg gtcgtcgtta cgagcccgct ccttccctgc acccatccta ccctgtgccc 10980 cctcctccat cacccgctta ctaccgtcgt cgtgactccc ccggtggcat ggacgagcct 11040 ccatctggat gggagcgtta cgacggttcc caccgtggcc agtcccaaaa gcagcaccgt 11100 cacggtggtt ccggtggtca caacaagcgt cgcaaggaag ccgctgctgc atcctccagc 11160 tccgacgagg acctgagctt ccccggcgag gctgaacacg gtcgtgctcg caagcgtctg 11220 aagtcccacg tgaactccga cggaggtagc ggaggccacg ctggttccaa ccagcagcag 11280 caacagcgct acgacgagct gcgtgacgct atccacgagc tgaagcgtga cctgttcgct 11340 gctcgccagt cctccaccct gctgtctgct gctctgccag ctgccgcttc ttcctcccct 11400 accaccacca ccgtgtgcac ccctactggc gagctgacct ctggtggtgg cgagactccc 11460 accgctctgc tgtccggtgg tgctaaggtg gccgagcgtg ctcaggctgg tgtcgtgaac 11520 gcttcctgcc gtctggctac cgcttccggt tccgaggctg ccaccgctgg tccctctacc 11580 gctggttcct catcctgccc agcttccgtg gtgctggctg ccgctgctgc tcaagccgcc 11640 gctgcttcac agtccccccc aaaggatatg gtggacctga accgtcgtat cttcgtggct 11700 gctctgaaca agctcgagta ataaaagctt gtcgagaagt actagaggat cataatcagc 11760 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 11820 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 11880 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 11940 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 12000 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgggaata ttaatagatc 12060 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 12120 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 12180 ggcgcggatc cgccaccatg gctgctatgg aagctaacat cttctgcacc ttcgaccaca 12240 agctgtctat cgctgacgtg ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc 12300 cccagcgtct gcacctgatc aagcactacc agctgggcct gcaccagttc gtggaccaca 12360 cccgtggtta cgtgcgtctg cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc 12420 gtgtcgaggg caaccagatc ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc 12480 tgaacaccgg tcccgtgacc tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt 12540 tccacggtcc cctggctcgt gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc 12600 cctggatcgt gcccatgccc ctggctctgg aaatcaacca gcgcctgctg atcatgggcc 12660 tgttctccct ggaccgttcc tacgaagaag tgaaggctgc tgtccagcag ctgcagacca 12720 tcaccttccg tgacgctacc ttcaccatcc ccgaccccgt gatcgaccag cacctcctga 12780 tcgacatgaa gaccgcttgc ctgtccatgt ccatggtggc taacctggct tccgagctga 12840 ccatgaccta cgtccgcaag ctggctttgg aggactcttc catgctgctg gtcaagtgcc 12900 aagagctgct gatgcgtctg gaccgcgagc gttccgtggg cgagcctcgt actcccgctc 12960 gtcctcagca cgtgtccccc gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc 13020 tgcgtcagct ggacgacctg atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc 13080 cagacaacaa gtccgctacc tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa 13140 gtactagagg atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa 13200 cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt 13260 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 13320 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 13380 tgtctggatc tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg 13440 aagctgagtt ggctgctgcc accgctgagc aataactatc ataaccccta ggggcctcta 13500 aacgggtctt gaggggtttt ttgctgaaag gaggaactat atccggatct gaacaggagg 13560 gacagctgat agaaacagaa gccactggag cacctcaaaa acaccatcat acactaaatc 13620 agtaagttgg cagcatcacc cgacgcactt tgcgccgaat aaatacctgt gacggaagat 13680 cacttcgcag aataaataaa tcctggtgtc cctgttgata ccgggaagcc ctgggccaac 13740 ttttggcgaa aatgagacgt tgatcggcac gtaagaggtt ccaactttca ccataatgaa 13800 ataagatcac taccgggcgt attttttgag ttatcgagat tttcaggagc taaggaagct 13860 aaaatggaga aaaaaatcac tggatatacc accgttgata tatcccaatg gcatcgtaaa 13920 gaacattttg aggcatttca gtcagttgct caatgtacct ataaccagac cgttcagctg 13980 gatattacgg cctttttaaa gaccgtaaag aaaaataagc acaagtttta tccggccttt 14040 attcacattc ttgcccgcct gatgaatgct catccggaat tccgtatggc aatgaaagac 14100 ggtgagctgg tgatatggga tagtgttcac ccttgttaca ccgttttcca tgagcaaact 14160 gaaacgtttt catcgctctg gagtgaatac cacgacgatt tccggcagtt tctacacata 14220 tattcgcaag atgtggcgtg ttacggtgaa aacctggcct atttccctaa agggtttatt 14280 gagaatatgt ttttcgtctc agccaatccc tgggtgagtt tcaccagttt tgatttaaac 14340 gtggccaata tggacaactt cttcgccccc gttttcacca tgggcaaata ttatacgcaa 14400 ggcgacaagg tgctgatgcc gctggcgatt caggttcatc atgccgtttg tgatggcttc 14460 catgtcggca gaatgcttaa tgaattacaa cagtactgcg atgagtggca gggcggggcg 14520 taattttttt aaggcagtta ttggtgccct taaacgcctg gttgctacgc ctgaataagt 14580 gataataagc ggatgaatgg cagaaattcg aaagcaaatt cgacccggtc gtcggttcag 14640 ggcagggtcg ttaaatagcc gcttatgtct attgctggtt taccggttta ttgactaccg 14700 gaagcagtgt gaccgtgtgc ttctcaaatg cctgaggcca gtttgctcag gctctccccg 14760 tggaggtaat aattgacgat atgatcattt attctgcctc ccagctgaca ttcatccggg 14820 gtcagcaccg tttctgcgga ctggctttct acgtgttccg cttcctttag cagcccttgc 14880 gccctgagtg cttgcggcag cgtgaagcta attctgtcag ccgttaagtg ttcctgtgtc 14940 actcaaaatt gctttgagag gctctaaggg cttctcagtg cgttacatcc ctggcttgtt 15000 gtccacaacc gttaaacctt aaaagcttta aaagccttat atattctttt ttttcttata 15060 aaacttaaaa ccttagaggc tatttaagtt gctgatttat attaatttta ttgttcaaac 15120 atgagagctt agtacgtgaa acatgagagc ttagtacgtt agccatgaga gcttagtacg 15180 ttagccatga gggtttagtt cgttaaacat gagagcttag tacgttaaac atgagagctt 15240 agtacgtgaa acatgagagc ttagtacgta ctatcaacag gttgaactgc tgatcaacag 15300 atcctctacg cggccgcggt accataactt cgtatagcat acattatacg aagttatctg 15360 gtttaaacgt acccgtagtg gctatggcag ggcttgccgc cccgacgttg gctgcgagcc 15420 ctgggccttc acccgaactt gggggttggg gtggggaaaa ggaagaaacg cgggcgtatt 15480 ggtcccaatg gggtctcggt ggggtatcga cagagtgcca gccctgggac cgaaccccgc 15540 gtttatgaac aaacgaccca acacccgtgc gttttattct gtctttttat tgccgtcata 15600 gcgcgggttc cttccggtat tgtctccttc cgtgtttcag ttagcctccc ccatctcccg 15660 gtaccgcatg ctatgcatca gctgctagct tagcgagcgt ccacagcctg gggaccgtaa 15720 cgggagtgag cgggcaggtt cacacgggtc tgcttcagct cagggggcag gccagcgtag 15780 tacttgtcca ggtgacgcag cagggggggg tccagctggt gacgcaggca gaattccttc 15840 acagcgttgt acaggccgta gaacagggtg ataccctcgg gagcagcagc ggtggacacg 15900 ggcagacgca cagcacggtt ggtacgggta gcctcgttac ggatagccac caccacgttg 15960 aacagggagg ggggcaccag ctcgaaaccc agcacgtgtt cggtgaagat ggaacgaccg 16020 taggacagac gagtcaggtc gtaaccacgg cacaggtcgt ccacgcaagt gtacacagcg 16080 ggggaaccgt cgccgcactc ggagtaaccg cgcatcacgg tcatccaacg gggagcggtg 16140 tcggaggaca gcagggtcag cagagcacgc agctggtcgg ggttgttgta cagcagggcc 16200 agggtgtcca ggaaagcgtc gtccagcagc acggagttag cagcctcggg ggtcacggga 16260 cggtaacgga tcagctggga caggggaccg tccctacggg tcacgttgac caggggacgc 16320 agccaggact cgtacttgtc gccctggaac acctctccca gcaggcaacg acgggtcagc 16380 tcggggcact cagcgggcac cttctcagcc acggtgggag ccacggacac ggtagcggag 16440 gacacgatgg gcagcagcag gcagcaccac agcagagcca cgggaccggg ggagaaggag 16500 aaaccgcagt cgggacgacg gcacatggtg gctcgagatc ccgggtgatc aagtcttcgt 16560 cgagtgattg taaataaaat gtaatttaca gtatagtatt ttaattaata tacaaatgat 16620 ttgataataa ttcttattta actataatat attgtgttgg gttgaattaa aggtccgtat 16680 actagtatcg attcgcgacc tactccggaa tattaataga tcatggagat aattaaaatg 16740 ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa 16800 aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccacca 16860 tgaactccaa ggacctgacc cccttcctga ccaccctgtg gctgctgctg gaccactccc 16920 gtgtgcctcg tgtgcgtgct gaggaatgct gcgaagtgat caacgtgaac cacccccccg 16980 agcgctgcta cgacttcaag atgtgcaacc tgttcaccgt ggctctgcgt tgccccgacg 17040 gcgaagtgtg ctactccccc gaaaagaccg ctgagatccg tggtatcgtg accaccatga 17100 cccactccct gacccgtcaa gtgatccaca acaagctgac cagctgcaac tacaaccccc 17160 tgtacctcga ggctgacggt cgtatccgtt gcggcaaggt gtccgacaag gctcagtacc 17220 tgctgggtgc tgctggttcc gtgccctacc gttggatcaa cctcgagtac gacaagatca 17280 cccgtatcgt gggcctggac cagtacctcg agtccgtgaa gaagcacaag cgtctggacg 17340 tgtgccgtgc taagatgggt tacatgctgc agtaaaagct tgtcgagaag tactagagga 17400 tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc 17460 tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag 17520 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 17580 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct 17640 gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg 17700 gctgctgtgg ctagctttgt ttaactttaa gaaggagata catctagacc ggaatattaa 17760 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 17820 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 17880 ccatcgggcg cggatccgcc accatgctgc gtctgctgct gcgtcaccac ttccactgcc 17940 tgctgctgtg cgctgtgtgg gctaccccct gcctggcttc cccttggtcc accctgaccg 18000 ctaaccagaa cccctcccca ccctggtcca agctgaccta ctccaagccc cacgacgctg 18060 ctaccttcta ctgccccttc ctgtacccat ccccccctcg ttccccactg cagttctccg 18120 gtttccagcg tgtgctgacc ggtcccgagt gccgtaacga gactctgtac ctgctgtaca 18180 accgcgaggg ccagaccctg gtcgagaggt cctccacctg ggtcaagaag gtcatctggt 18240 acttgtccgg tcgtaaccag accatcctgc agcgtatgcc ccgtaccgct tccaagccct 18300 ccgacggcaa cgtgcagatc tccgtcgagg acgctaagat cttcggtgct cacatggtgc 18360 ccaagcagac caagctgctg cgtttcgtgg tcaacgacgg cacccgttac cagatgtgcg 18420 tgatgaagct cgagtcctgg gctcacgtgt tccgtgacta ctccgtgtcc ttccaagtgc 18480 gcctgacctt caccgaggct aacaaccaga cctacacctt ctgcacccac cccaacctga 18540 tcgtgtaaaa gcttgtcgag aagtactaga ggatcataat cagccatacc acatttgtag 18600 aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga 18660 atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata 18720 gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca 18780 aactcatcaa tgtatcttat catgtctgga tctgatcact gcttgagcct agaagatccg 18840 gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ggtgcctaat gagtgagcta 18900 actcacatta attgcccgga atattaatag atcatggaga taattaaaat gataaccatc 18960 tcgcaaataa ataagtattt tactgttttc gtaacagttt tgtaataaaa aaacctataa 19020 atattccgga ttattcatac cgtcccacca tcgggcgcgg atccgccacc atgcgtctgt 19080 gccgtgtgtg gctgtccgtg tgcctgtgcg ctgtggtgct gggccagtgc cagcgtgaaa 19140 ccgctgagaa gaacgactac taccgtgtgc cccactactg ggacgcttgc tcccgtgctc 19200 tgcccgacca gacccgttac aagtacgtcg agcagctggt ggacctgacc ctgaactacc 19260 actacgacgc ttcccacggc ctggacaact tcgacgtgct gaagcgtatc aacgtgaccg 19320 aggtgtccct gctgatctcc gacttccgtc gtcagaaccg tcgtggtggc accaacaagc 19380 gtaccacctt caacgctgct ggttccctgg ctccccacgc tcgttccctc gagttctccg 19440 tgcgtctgtt cgctaactaa aagcttgtcg agaagtacta gaggatcata atcagccata 19500 ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga 19560 aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca 19620 aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt 19680 gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc 19740 ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct 19800 gagcaataac tatcataacc cccggaatat taatagatca tggagataat taaaatgata 19860 accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac 19920 ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc cggtccgaag 19980 cgcgcggaat tcaaaggcct accgtcgacg ccaccatgga atcccgtatc tggtgcctgg 20040 tcgtgtgcgt gaacctgtgc atcgtgtgcc tgggtgctgc tgtgtcctcc tcctccaccc 20100 gtggcacctc cgctacccac tcccaccact cctcccacac cacctccgcc gctcactccc 20160 gttccggttc cgtgtcccag cgtgtgacct cctcccagac cgtgtcccac ggtgtcaacg 20220 agactatcta caacaccacc ctgaagtacg gcgacgtcgt gggtgtcaac accaccaagt 20280 acccctaccg tgtgtgctcc atggctcagg gcaccgacct gatccgtttc gagcgtaaca 20340 tcgtgtgcac ctccatgaag cccatcaacg aggacctgga cgagggtatc atggtggtgt 20400 acaagcgcaa catcgtggct cacaccttca aggtccgcgt gtaccagaag gtgctgacct 20460 tccgtcgttc ctacgcttac atccacacca cttacctgct gggttccaac accgagtacg 20520 tggcccctcc catgtgggag atccaccaca tcaactccca ctcccagtgc tactcctctt 20580 actcccgtgt gatcgctggc accgtgttcg tggcttacca ccgtgactcc tacgagaaca 20640 agaccatgca gctgatgccc gacgactact ccaacaccca ctccacccgt tacgtgaccg 20700 tgaaggacca gtggcactcc cgtggttcca cctggctgta ccgtgaaacc tgcaacctga 20760 actgcatggt caccatcacc accgctcgtt ccaagtaccc ttaccacttc ttcgctacct 20820 ccaccggcga cgtggtggac atctccccct tctacaacgg tactaaccgt aacgcttcct 20880 acttcggcga gaacgctgac aagttcttca tcttccccaa ctacaccatc gtgtccgact 20940 tcggtcgtcc caactccgct ctggaaaccc accgtctggt ggctttcttg gagcgtgctg 21000 actccgtgat ctcctgggac atccaggacg agaagaacgt gacctgccag ctgaccttct 21060 gggaggcttc cgagcgtacc atccgttccg aggctgagga ctcctaccac ttctccagcg 21120 ctaagatgac cgctaccttc ctgtccaaga aacaagaggt caacatgtcc gactccgccc 21180 tggactgcgt gcgtgacgag gctatcaaca agctgcagca gatcttcaac acctcctaca 21240 accagaccta cgagaagtac ggaaacgtgt ccgtgttcga gactaccggt ggcctggtgg 21300 tgttctggca gggtatcaag cagaagtccc tggtcgagct ggaacgtctg gctaaccgtt 21360 cctccctgaa cctgacccac aaccgtacca agcgttccac cgacggcaac aacgctactc 21420 acctgtccaa catggaatcc gtgcacaacc tggtgtacgc tcagctgcag ttcacctacg 21480 acaccctgcg cggttacatc aaccgtgctc tggctcagat cgctgaggct tggtgcgtgg 21540 accagcgtcg taccctggaa gtgttcaagg aactgtccaa gatcaacccc tccgctatcc 21600 tgtccgccat ctacaacaag cctatcgctg ctcgtttcat gggcgacgtg ctgggcctgg 21660 cttcctgcgt gaccatcaac cagacttccg tgaaggtgct gcgtgacatg aacgtgaagg 21720 aatcccccgg tcgttgctac tcccgtcccg tggtcatctt caacttcgct aactcctcct 21780 acgtgcagta cggccagctg ggcgaggaca acgagatcct gctgggcaac caccgtaccg 21840 aggaatgcca gctgccctcc ctgaagatct tcatcgctgg caactccgct tacgaatacg 21900 tggactacct gttcaagcgc atgatcgacc tgtcctccat ctctaccgtg gactccatga 21960 tcgctctgga catcgacccc ctggaaaaca ccgacttccg tgtgctggaa ctgtactccc 22020 agaaggaact gcgttccatc aacgtgttcg acctggaaga gatcatgcgc gagttcaact 22080 cctacaagca gcgtgttaag tacgtcgagg acaaggtggt ggaccccctg cccccctacc 22140 tgaagggact ggacgacctg atgtccggcc tgggagctgc cggcaaggct gtgggtgtcg 22200 ctatcggtgc tgtgggtggt gctgtggctt ccgtggtcga gggtgtcgcc accttcctga 22260 agaacccctt cggtgctttc accatcatcc tggtggctat cgctgtggtc atcatcatct 22320 acctgatcta cacccgtcag cgtcgtctgt gcatgcagcc cctgcagaac ctgttcccct 22380 acctggtgtc cgctgacggt actaccgtga cctccggcaa caccaaggac acctccctgc 22440 aggctccccc atcctacgag gaatccgtct acaactccgg tcgcaagggt cccggtcccc 22500 cttcctccga cgcttctacc gctgctcccc catacaccaa cgagcaggct taccagatgc 22560 tgctggctct cgtgcgtctg gacgctgagc agcgtgcaca gcagaacggc accgactccc 22620 tggacggcca gaccggaacc caggacaagg gccagaagcc caacctgctg gaccgtctgc 22680 gtcaccgcaa gaacggttac cgtcacctga aggactccga cgaggaagag aacgtctaag 22740 gcgcgccaag cttgtcgaga agtactagag atcataatca gccataccac atttgtagag 22800 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 22860 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 22920 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 22980 ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc 23040 tgctaacaaa gcccgaaagg aagctgggaa tattaataga tcatggagat aattaaaatg 23100 ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa 23160 aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccacca 23220 tgcgtcccgg cctgccctcc tacctgatcg tgctggctgt gtgcctgctg tcccacctcc 23280 tgtcctcccg ttacggtgct gaggctatct ccgagcccct ggacaaggct ttccacctcc 23340 tgctgaacac ctacggtcgt cctatccgtt tcctgcgcga gaacaccacc cagtgcacct 23400 acaactcctc cctgcgcaac tccaccgtcg tccgcgagaa cgctatctcc ttcaacttct 23460 tccagtccta caaccagtac tacgtgttcc acatgccccg ttgcctgttc gctggtcccc 23520 tggctgagca gttcctgaac caggtggacc tgaccgagac tctcgagcgt taccagcagc 23580 gtctgaacac ttacgctctg gtgtccaagg acctggcttc ctaccgttcc ttcagccagc 23640 agctgaaggc tcaggactcc ctgggcgagc agcccaccac tgtgcctccc cctatcgacc 23700 tgtccatccc ccacgtgtgg atgccccccc agaccactcc tcacggctgg accgagtccc 23760 acaccacctc cggactgcac cgtccccact tcaaccagac ctgcatcctg ttcgacggtc 23820 acgacctgct gttctccacc gtgaccccct gcctgcacca gggcttctac ctcatcgacg 23880 agctgcgtta cgtgaagatc accctgaccg aggatttctt cgtggtcacc gtgtccatcg 23940 acgacgacac ccccatgctg ctgatcttcg gtcacctccc ccgtgtgctg ttcaaggctc 24000 cctaccagcg tgacaacttc atcctgcgtc agaccgagaa gcacgagctg ctggtgctgg 24060 tcaagaagga ccagctgaac cgtcactctt acctgaagga ccccgacttc ctggacgctg 24120 ctctggactt caactacctg gacctgtccg ctctgctgag gaactccttc caccgttacg 24180 ctgtggacgt gctgaagtcc ggtcgttgcc agatgctgga ccgtcgtacc gtcgagatgg 24240 ctttcgctta cgccctggct ctgttcgctg ctgctcgtca agaagaggct ggcgctcagg 24300 tgtccgtgcc ccgtgctctg gaccgtcagg ctgctctgct gcagatccaa gagttcatga 24360 tcacttgcct gtcccagacc ccccctcgta ccaccctgct gctgtacccc accgctgtgg 24420 acctggctaa gcgtgctctg tggaccccca accagatcac cgacatcacc tccctcgtgc 24480 gtctggtgta catcctgtcc aagcagaacc agcagcacct gatcccccag tgggctctgc 24540 gtcagatcgc tgacttcgct ctgaagctgc acaagaccca cctggcttca ttcctcagcg 24600 ctttcgctcg ccaagagctg tacctgatgg gttccctggt gcactccatg ctggtgcaca 24660 ccaccgagcg tcgcgagatc ttcatcgtgg aaaccggcct gtgctccctg gccgagctgt 24720 cccacttcac ccagctgctg gctcaccccc accacgagta cctgtccgac ctgtacaccc 24780 cctgctcctc ttccggtcgt cgtgaccact ccctggaacg tctgacccgt ctgttccccg 24840 acgctaccgt gcctaccacc gtgcctgctg ctctgtccat cctgtctacc atgcagccct 24900 ccaccctgga aaccttcccc gacctgttct gcctgcctct gggcgagtcc ttctccgctc 24960 tgaccgtgtc cgagcacgtg tcctacgtgg tcaccaacca gtacctgatc aagggcatct 25020 cctaccccgt gtccaccacc gtcgtgggcc agtccctgat catcacccag accgactccc 25080 agaccaagtg cgagctgacc cgtaacatgc acaccactca ctccatcacc gctgctctga 25140 acatctccct cgagaactgc gctttctgcc agtccgctct gttggagtac gacgacactc 25200 agggtgtcat caacatcatg tacatgcacg actccgacga cgtgctgttc gctctggacc 25260 cctacaacga ggtggtggtg tcctcccccc gtacccacta cctgatgctg ctgaagaacg 25320 gcaccgtgct ggaagtgacc gacgtggtgg tggacgctac cgaccgtctg ctgatgatgt 25380 ccgtgtacgc tctgtccgct atcatcggca tctacctgct gtaccgtatg ctgaagacct 25440 gctaaggcgc caagctttgt cgagaagtac tagaggatca taatcagcca taccacattt 25500 gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa 25560 atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc 25620 aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 25680 tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga 25740 tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgccaccg ctgagcaata 25800 actatcataa cccctaggag atccgaacca gataagtgaa atctagttcc aaactatttt 25860 gtcattttta attttcgtat tagcttacga cgctacaccc agttcccatc tattttgtca 25920 ctcttcccta aataatcctt aaaaactcca tttccacccc tcccagttcc caactatttt 25980 gtccgcccac a 25991 <210> 44 <211> 26012 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 44 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgtggctagc tttgtttaac tttaagaagg agatacatct agaccggaat attaatagat 7200 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 7260 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 7320 gggcgcggat cccggtccga agcgcgcgga attcaaaggc ctacgtcgac gccaccatgg 7380 aatcccgtgg tcgtcgttgc cccgagatga tctccgtgct gggtcccatc tccggtcacg 7440 tcctgaaggc tgtgttctcc cgtggcgaca cccccgtgct gccccacgaa actcgtctgc 7500 tgcagaccgg tatccacgtg cgtgtgtccc agccctccct gatcctggtg tcccagtaca 7560 cccccgactc caccccttgc caccgcggag acaaccagct gcaggtccag cacacctact 7620 tcaccggttc cgaggtcgag aacgtgtccg tgaacgtgca caaccccacc ggtcgttcca 7680 tctgcccctc ccaagagccc atgtccatct acgtgtacgc tctgcccctg aagatgctga 7740 acatcccctc catcaacgtg caccactacc cctccgctgc tgagcgcaag caccgtcacc 7800 tccccgtggc tgacgctgtg atccacgctt ccggcaagca gatgtggcag gctcgtctga 7860 ccgtgtccgg cctggcttgg acccgtcagc agaaccagtg gaaggaaccc gacgtgtact 7920 acacctccgc tttcgtgttc cccaccaagg acgtggccct gcgtcacgtc gtgtgcgctc 7980 acgaactcgt gtgctccatg gaaaacaccc gtgctaccaa gatgcaagtg atcggcgacc 8040 agtacgtgaa ggtgtacctg gaatccttct gcgaggacgt gccctccggc aagctgttca 8100 tgcacgtgac cctgggttcc gacgtggaag aggacctgac catgacccgt aacccccagc 8160 ccttcatgcg tccccacgag cgtaacggtt tcaccgtgct gtgccccaag aacatgatca 8220 tcaagcccgg caagatctcc cacatcatgc tggacgtggc cttcacctcc cacgagcact 8280 tcggcctgct gtgccctaag tccatccccg gcctgtccat ctccggcaac ctgctgatga 8340 acggccagca gatcttcctg gaagtgcagg ctatccgtga aaccgtcgag ctgcgtcagt 8400 acgaccctgt ggctgctctg ttcttcttcg acatcgacct gctgctgcag cgtggtcccc 8460 agtactccga gcaccccacc ttcaccagcc agtaccgtat ccagggcaag ctggaatacc 8520 gtcacacctg ggaccgtcac gacgagggtg ctgctcaggg cgacgacgac gtgtggacct 8580 ccggttccga ctccgacgag gaactggtca ccaccgagcg caagaccccc cgtgtgaccg 8640 gtggtggtgc tatggctggt gcttccacct ccgctggtcg caagcgcaag tccgcttcct 8700 ccgctaccgc ttgcaccgct ggtgtcatga cccgtggtcg cctgaaggct gagtccaccg 8760 tggctcccga agaggacact gacgaggact ccgacaacga gatccacaac cccgctgtgt 8820 tcacctggcc cccctggcag gctggtatcc tggctcgtaa cctggtgccc atggtggcta 8880 ccgtgcaggg ccagaacctg aagtaccaag agttcttctg ggacgccaac gacatctacc 8940 gtatcttcgc tgagctggaa ggcgtgtggc agcccgctgc tcagcccaag cgtcgtcgtc 9000 accgtcagga cgctctgcct ggtccctgta tcgcttccac ccccaagaag caccgcggct 9060 aaaagcttgt cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt 9120 tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa 9180 ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca 9240 caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca 9300 tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga tccggctgct 9360 aacaaagccc gaaaggaagc tgagttggct gctgccaccg ctgagcaata actatcataa 9420 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 9480 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 9540 cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt cgccaccatg 9600 accatggacg agcagcagcc ccaggctgtg acccccgtgt acgtgggcgg tttcctggct 9660 cgttacgacc agtcccccga cgaggctgag ctgctgctgc cacgtgacgt ggtcgaacac 9720 tggctgcacg ctcagggcca gggacagcct tccctgtccg tggctctgcc cctgaacatc 9780 aaccacgacg acaccgctgt cgtgggtcac gtggccgcta tgcagtccgt gcgtgacggc 9840 ctgttctgcc tgggttgcgt gacctccccc cgtttcctgg aaatcgtgcg tcgtgcttcc 9900 gagaagtccg agctggtgtc ccgtggtccc gtgtccccac tgcagcccga caaggtggtc 9960 gagttcctgt ccggttccta cgctggcctg tccctgtcat cccgtcgttg cgacgacgtc 10020 gaggctgcta cctccctgag cggctccgag actaccccct tcaagcacgt ggccctgtgc 10080 tccgtgggtc gtaggcgtgg aaccctggct gtgtacggtc gtgaccccga gtgggtcacc 10140 cagcgtttcc ccgacctgac cgctgctgac cgtgacggac tgcgtgctca gtggcagcgt 10200 tgcggttcca ccgctgtgga cgcttccggc gaccccttcc gttccgactc ctacggcctg 10260 ctgggcaact ccgtggacgc tctgtacatc cgcgagcgtc tgcccaagct gcgttacgac 10320 aagcagctcg tgggtgtcac cgagcgcgag tcctacgtga aggcttccgt gtcccccgag 10380 gctgcttgcg acatcaaggc tgcttccgct gagcgttctg gcgacagccg ctcccaggct 10440 gctactcctg ctgctggtgc tcgtgtgccc tccagctccc catccccacc tgtcgagcct 10500 ccctcccccg tgcaacctcc tgctctgcct gcttccccct ccgtgctgcc tgctgagtcc 10560 agcccctccc tgtcaccctc tgagcctgct gaggctgcct ccatgtccca ccctctgagc 10620 gctgctgtga ctgctgctac cgctccccct ggtgctactg tggctggtgc ttcccccgct 10680 gtgccttccc tggcttggcc tcacgacggt gtctacctgc ccaaggacgc tttcttctcc 10740 ctgctgggcg cttcccgttc cgctgctccc gtgatgtacc ccggtgctgt ggctgctccc 10800 cccagcgctt cacctgctcc tctgcccctg ccctcctacc ccgcttccta cggtgctccc 10860 gtcgtgggtt acgaccagct ggctgctcgt cacttcgctg actacgtgga cccccactac 10920 cccggctggg gtcgtcgtta cgagcccgct ccttccctgc acccatccta ccctgtgccc 10980 cctcctccat cacccgctta ctaccgtcgt cgtgactccc ccggtggcat ggacgagcct 11040 ccatctggat gggagcgtta cgacggttcc caccgtggcc agtcccaaaa gcagcaccgt 11100 cacggtggtt ccggtggtca caacaagcgt cgcaaggaag ccgctgctgc atcctccagc 11160 tccgacgagg acctgagctt ccccggcgag gctgaacacg gtcgtgctcg caagcgtctg 11220 aagtcccacg tgaactccga cggaggtagc ggaggccacg ctggttccaa ccagcagcag 11280 caacagcgct acgacgagct gcgtgacgct atccacgagc tgaagcgtga cctgttcgct 11340 gctcgccagt cctccaccct gctgtctgct gctctgccag ctgccgcttc ttcctcccct 11400 accaccacca ccgtgtgcac ccctactggc gagctgacct ctggtggtgg cgagactccc 11460 accgctctgc tgtccggtgg tgctaaggtg gccgagcgtg ctcaggctgg tgtcgtgaac 11520 gcttcctgcc gtctggctac cgcttccggt tccgaggctg ccaccgctgg tccctctacc 11580 gctggttcct catcctgccc agcttccgtg gtgctggctg ccgctgctgc tcaagccgcc 11640 gctgcttcac agtccccccc aaaggatatg gtggacctga accgtcgtat cttcgtggct 11700 gctctgaaca agctcgagta ataaaagctt gtcgagaagt actagaggat cataatcagc 11760 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 11820 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 11880 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 11940 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 12000 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgggaata ttaatagatc 12060 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 12120 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 12180 ggcgcggatc cgccaccatg gctgctatgg aagctaacat cttctgcacc ttcgaccaca 12240 agctgtctat cgctgacgtg ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc 12300 cccagcgtct gcacctgatc aagcactacc agctgggcct gcaccagttc gtggaccaca 12360 cccgtggtta cgtgcgtctg cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc 12420 gtgtcgaggg caaccagatc ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc 12480 tgaacaccgg tcccgtgacc tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt 12540 tccacggtcc cctggctcgt gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc 12600 cctggatcgt gcccatgccc ctggctctgg aaatcaacca gcgcctgctg atcatgggcc 12660 tgttctccct ggaccgttcc tacgaagaag tgaaggctgc tgtccagcag ctgcagacca 12720 tcaccttccg tgacgctacc ttcaccatcc ccgaccccgt gatcgaccag cacctcctga 12780 tcgacatgaa gaccgcttgc ctgtccatgt ccatggtggc taacctggct tccgagctga 12840 ccatgaccta cgtccgcaag ctggctttgg aggactcttc catgctgctg gtcaagtgcc 12900 aagagctgct gatgcgtctg gaccgcgagc gttccgtggg cgagcctcgt actcccgctc 12960 gtcctcagca cgtgtccccc gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc 13020 tgcgtcagct ggacgacctg atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc 13080 cagacaacaa gtccgctacc tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa 13140 gtactagagg atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa 13200 cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt 13260 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 13320 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 13380 tgtctggatc tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg 13440 aagctgagtt ggctgctgcc accgctgagc aataactatc ataaccccta ggggcctcta 13500 aacgggtctt gaggggtttt ttgctgaaag gaggaactat atccggatct gaacaggagg 13560 gacagctgat agaaacagaa gccactggag cacctcaaaa acaccatcat acactaaatc 13620 agtaagttgg cagcatcacc cgacgcactt tgcgccgaat aaatacctgt gacggaagat 13680 cacttcgcag aataaataaa tcctggtgtc cctgttgata ccgggaagcc ctgggccaac 13740 ttttggcgaa aatgagacgt tgatcggcac gtaagaggtt ccaactttca ccataatgaa 13800 ataagatcac taccgggcgt attttttgag ttatcgagat tttcaggagc taaggaagct 13860 aaaatggaga aaaaaatcac tggatatacc accgttgata tatcccaatg gcatcgtaaa 13920 gaacattttg aggcatttca gtcagttgct caatgtacct ataaccagac cgttcagctg 13980 gatattacgg cctttttaaa gaccgtaaag aaaaataagc acaagtttta tccggccttt 14040 attcacattc ttgcccgcct gatgaatgct catccggaat tccgtatggc aatgaaagac 14100 ggtgagctgg tgatatggga tagtgttcac ccttgttaca ccgttttcca tgagcaaact 14160 gaaacgtttt catcgctctg gagtgaatac cacgacgatt tccggcagtt tctacacata 14220 tattcgcaag atgtggcgtg ttacggtgaa aacctggcct atttccctaa agggtttatt 14280 gagaatatgt ttttcgtctc agccaatccc tgggtgagtt tcaccagttt tgatttaaac 14340 gtggccaata tggacaactt cttcgccccc gttttcacca tgggcaaata ttatacgcaa 14400 ggcgacaagg tgctgatgcc gctggcgatt caggttcatc atgccgtttg tgatggcttc 14460 catgtcggca gaatgcttaa tgaattacaa cagtactgcg atgagtggca gggcggggcg 14520 taattttttt aaggcagtta ttggtgccct taaacgcctg gttgctacgc ctgaataagt 14580 gataataagc ggatgaatgg cagaaattcg aaagcaaatt cgacccggtc gtcggttcag 14640 ggcagggtcg ttaaatagcc gcttatgtct attgctggtt taccggttta ttgactaccg 14700 gaagcagtgt gaccgtgtgc ttctcaaatg cctgaggcca gtttgctcag gctctccccg 14760 tggaggtaat aattgacgat atgatcattt attctgcctc ccagctgaca ttcatccggg 14820 gtcagcaccg tttctgcgga ctggctttct acgtgttccg cttcctttag cagcccttgc 14880 gccctgagtg cttgcggcag cgtgaagcta attctgtcag ccgttaagtg ttcctgtgtc 14940 actcaaaatt gctttgagag gctctaaggg cttctcagtg cgttacatcc ctggcttgtt 15000 gtccacaacc gttaaacctt aaaagcttta aaagccttat atattctttt ttttcttata 15060 aaacttaaaa ccttagaggc tatttaagtt gctgatttat attaatttta ttgttcaaac 15120 atgagagctt agtacgtgaa acatgagagc ttagtacgtt agccatgaga gcttagtacg 15180 ttagccatga gggtttagtt cgttaaacat gagagcttag tacgttaaac atgagagctt 15240 agtacgtgaa acatgagagc ttagtacgta ctatcaacag gttgaactgc tgatcaacag 15300 atcctctacg cggccgcggt accataactt cgtatagcat acattatacg aagttatctg 15360 gtttaaacgt acccgtagtg gctatggcag ggcttgccgc cccgacgttg gctgcgagcc 15420 ctgggccttc acccgaactt gggggttggg gtggggaaaa ggaagaaacg cgggcgtatt 15480 ggtcccaatg gggtctcggt ggggtatcga cagagtgcca gccctgggac cgaaccccgc 15540 gtttatgaac aaacgaccca acacccgtgc gttttattct gtctttttat tgccgtcata 15600 gcgcgggttc cttccggtat tgtctccttc cgtgtttcag ttagcctccc ccatctcccg 15660 gtaccgcatg ctatgcatca gctgctagct tagcgagcgt ccacagcctg gggaccgtaa 15720 cgggagtgag cgggcaggtt cacacgggtc tgcttcagct cagggggcag gccagcgtag 15780 tacttgtcca ggtgacgcag cagggggggg tccagctggt gacgcaggca gaattccttc 15840 acagcgttgt acaggccgta gaacagggtg ataccctcgg gagcagcagc ggtggacacg 15900 ggcagacgca cagcacggtt ggtacgggta gcctcgttac ggatagccac caccacgttg 15960 aacagggagg ggggcaccag ctcgaaaccc agcacgtgtt cggtgaagat ggaacgaccg 16020 taggacagac gagtcaggtc gtaaccacgg cacaggtcgt ccacgcaagt gtacacagcg 16080 ggggaaccgt cgccgcactc ggagtaaccg cgcatcacgg tcatccaacg gggagcggtg 16140 tcggaggaca gcagggtcag cagagcacgc agctggtcgg ggttgttgta cagcagggcc 16200 agggtgtcca ggaaagcgtc gtccagcagc acggagttag cagcctcggg ggtcacggga 16260 cggtaacgga tcagctggga caggggaccg tccctacggg tcacgttgac caggggacgc 16320 agccaggact cgtacttgtc gccctggaac acctctccca gcaggcaacg acgggtcagc 16380 tcggggcact cagcgggcac cttctcagcc acggtgggag ccacggacac ggtagcggag 16440 gacacgatgg gcagcagcag gcagcaccac agcagagcca cgggaccggg ggagaaggag 16500 aaaccgcagt cgggacgacg gcacatggtg gctcgagatc ccgggtgatc aagtcttcgt 16560 cgagtgattg taaataaaat gtaatttaca gtatagtatt ttaattaata tacaaatgat 16620 ttgataataa ttcttattta actataatat attgtgttgg gttgaattaa aggtccgtat 16680 actagtatcg attcgcgacc tactccggaa tattaataga tcatggagat aattaaaatg 16740 ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa 16800 aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccacca 16860 tgaactccaa ggacctgacc cccttcctga ccaccctgtg gctgctgctg gaccactccc 16920 gtgtgcctcg tgtgcgtgct gaggaatgct gcgaagtgat caacgtgaac cacccccccg 16980 agcgctgcta cgacttcaag atgtgcaacc tgttcaccgt ggctctgcgt tgccccgacg 17040 gcgaagtgtg ctactccccc gaaaagaccg ctgagatccg tggtatcgtg accaccatga 17100 cccactccct gacccgtcaa gtgatccaca acaagctgac cagctgcaac tacaaccccc 17160 tgtacctcga ggctgacggt cgtatccgtt gcggcaaggt gtccgacaag gctcagtacc 17220 tgctgggtgc tgctggttcc gtgccctacc gttggatcaa cctcgagtac gacaagatca 17280 cccgtatcgt gggcctggac cagtacctcg agtccgtgaa gaagcacaag cgtctggacg 17340 tgtgccgtgc taagatgggt tacatgctgc agtaaaagct tgtcgagaag tactagagga 17400 tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc 17460 tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag 17520 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 17580 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct 17640 gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg 17700 gctgctgtgg ctagctttgt ttaactttaa gaaggagata catctagacc ggaatattaa 17760 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 17820 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 17880 ccatcgggcg cggatccgcc accatgctgc gtctgctgct gcgtcaccac ttccactgcc 17940 tgctgctgtg cgctgtgtgg gctaccccct gcctggcttc cccctggttc accctgaccg 18000 ctaaccagaa cccctcccca ccctggtcca agctgaccta ccccaagccc cacgacgctg 18060 ctaccttcta ctgccccttc ctgtacccat ccccacctcg ttccccatcc cagttctccg 18120 gtttccagcg tgtgtccacc ggtcccgagt gccgtaacga gactctgtac ctgctgtaca 18180 accgcgaggg ccagaccctg gtcgagaggt cctccacctg ggtcaagaag gtcatctggt 18240 acttgtccgg tcgtaaccag accatcctgc agcgtatgcc ccgtaccgct tccaagccct 18300 ccgacggcaa cgtgcagatc tccgtcgagg acgctaagat cttcggtgct cacatggtgc 18360 ccaagcagac caagctgctg cgtttcgtgg tcaacgacgg cacccgttac cagatgtgcg 18420 tgatgaagct ggaatcctgg gctcacgtgt tccgtgacta ctccgtgtcc ttccaagtgc 18480 gcctgacctt caccgaggct aacaaccaga cctacacctt ctgcacccac cccaacctga 18540 tcgtgtaagt cgacaagctt gtcgagaagt actagaggat cataatcagc cataccacat 18600 ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata 18660 aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa 18720 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 18780 tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa 18840 gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgggtg cctaatgagt 18900 gagctaactc acattaattg cccggaatat taatagatca tggagataat taaaatgata 18960 accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta ataaaaaaac 19020 ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc gccaccggat 19080 ccgccaccat gcgtctgtgc cgtgtgtggc tgtccgtgtg cctgtgcgct gtggtgctgg 19140 gacagtgcca gcgtgaaacc gctgagaaga acgactacta ccgtgtgccc cactactggg 19200 acgcttgctc ccgtgctctg cccgaccaga cccgttacaa gtacgtcgag cagctggtgg 19260 acctgaccct gaactaccac tacgacgctt cccacggcct ggacaacttc gacgtgctga 19320 agcgtatcaa cgtgaccgag gtgtccctgc tgatctccga cttccgtcgt cagaaccgtc 19380 gtggtggcac caacaagcgt accaccttca acgctgctgg ttccctggct ccccacgctc 19440 gttccttgga gttctccgtg cgtctgttcg ccaactaata aaagcttgtc gagaagtact 19500 agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc 19560 cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta 19620 ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat 19680 ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct 19740 ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg aaaggaagct 19800 gagttggctg ctgccaccgc tgagcaataa ctatcataac ccccggaata ttaatagatc 19860 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 19920 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 19980 ggcgcggatc ccggtccgaa gcgcgcggaa ttcaaaggcc taccgtcgac gccaccatgg 20040 aatcccgtat ctggtgcctg gtcgtgtgcg tgaacctgtg catcgtgtgc ctgggtgctg 20100 ctgtgtcctc ctcctccacc cgtggcacct ccgctaccca ctcccaccac tcctcccaca 20160 ccacctccgc cgctcactcc cgttccggtt ccgtgtccca gcgtgtgacc tcctcccaga 20220 ccgtgtccca cggtgtcaac gagactatct acaacaccac cctgaagtac ggcgacgtcg 20280 tgggtgtcaa caccaccaag tacccctacc gtgtgtgctc catggctcag ggcaccgacc 20340 tgatccgttt cgagcgtaac atcgtgtgca cctccatgaa gcccatcaac gaggacctgg 20400 acgagggtat catggtggtg tacaagcgca acatcgtggc tcacaccttc aaggtccgcg 20460 tgtaccagaa ggtgctgacc ttccgtcgtt cctacgctta catccacacc acttacctgc 20520 tgggttccaa caccgagtac gtggcccctc ccatgtggga gatccaccac atcaactccc 20580 actcccagtg ctactcctct tactcccgtg tgatcgctgg caccgtgttc gtggcttacc 20640 accgtgactc ctacgagaac aagaccatgc agctgatgcc cgacgactac tccaacaccc 20700 actccacccg ttacgtgacc gtgaaggacc agtggcactc ccgtggttcc acctggctgt 20760 accgtgaaac ctgcaacctg aactgcatgg tcaccatcac caccgctcgt tccaagtacc 20820 cttaccactt cttcgctacc tccaccggcg acgtggtgga catctccccc ttctacaacg 20880 gtactaaccg taacgcttcc tacttcggcg agaacgctga caagttcttc atcttcccca 20940 actacaccat cgtgtccgac ttcggtcgtc ccaactccgc tctggaaacc caccgtctgg 21000 tggctttctt ggagcgtgct gactccgtga tctcctggga catccaggac gagaagaacg 21060 tgacctgcca gctgaccttc tgggaggctt ccgagcgtac catccgttcc gaggctgagg 21120 actcctacca cttctccagc gctaagatga ccgctacctt cctgtccaag aaacaagagg 21180 tcaacatgtc cgactccgcc ctggactgcg tgcgtgacga ggctatcaac aagctgcagc 21240 agatcttcaa cacctcctac aaccagacct acgagaagta cggaaacgtg tccgtgttcg 21300 agactaccgg tggcctggtg gtgttctggc agggtatcaa gcagaagtcc ctggtcgagc 21360 tggaacgtct ggctaaccgt tcctccctga acctgaccca caaccgtacc aagcgttcca 21420 ccgacggcaa caacgctact cacctgtcca acatggaatc cgtgcacaac ctggtgtacg 21480 ctcagctgca gttcacctac gacaccctgc gcggttacat caaccgtgct ctggctcaga 21540 tcgctgaggc ttggtgcgtg gaccagcgtc gtaccctgga agtgttcaag gaactgtcca 21600 agatcaaccc ctccgctatc ctgtccgcca tctacaacaa gcctatcgct gctcgtttca 21660 tgggcgacgt gctgggcctg gcttcctgcg tgaccatcaa ccagacttcc gtgaaggtgc 21720 tgcgtgacat gaacgtgaag gaatcccccg gtcgttgcta ctcccgtccc gtggtcatct 21780 tcaacttcgc taactcctcc tacgtgcagt acggccagct gggcgaggac aacgagatcc 21840 tgctgggcaa ccaccgtacc gaggaatgcc agctgccctc cctgaagatc ttcatcgctg 21900 gcaactccgc ttacgaatac gtggactacc tgttcaagcg catgatcgac ctgtcctcca 21960 tctctaccgt ggactccatg atcgctctgg acatcgaccc cctggaaaac accgacttcc 22020 gtgtgctgga actgtactcc cagaaggaac tgcgttccat caacgtgttc gacctggaag 22080 agatcatgcg cgagttcaac tcctacaagc agcgtgttaa gtacgtcgag gacaaggtgg 22140 tggaccccct gcccccctac ctgaagggac tggacgacct gatgtccggc ctgggagctg 22200 ccggcaaggc tgtgggtgtc gctatcggtg ctgtgggtgg tgctgtggct tccgtggtcg 22260 agggtgtcgc caccttcctg aagaacccct tcggtgcttt caccatcatc ctggtggcta 22320 tcgctgtggt catcatcatc tacctgatct acacccgtca gcgtcgtctg tgcatgcagc 22380 ccctgcagaa cctgttcccc tacctggtgt ccgctgacgg tactaccgtg acctccggca 22440 acaccaagga cacctccctg caggctcccc catcctacga ggaatccgtc tacaactccg 22500 gtcgcaaggg tcccggtccc ccttcctccg acgcttctac cgctgctccc ccatacacca 22560 acgagcaggc ttaccagatg ctgctggctc tcgtgcgtct ggacgctgag cagcgtgcac 22620 agcagaacgg caccgactcc ctggacggcc agaccggaac ccaggacaag ggccagaagc 22680 ccaacctgct ggaccgtctg cgtcaccgca agaacggtta ccgtcacctg aaggactccg 22740 acgaggaaga gaacgtctaa ggcgcgccaa gcttgtcgag aagtactaga gatcataatc 22800 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 22860 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 22920 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 22980 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 23040 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctggga atattaatag 23100 atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc 23160 gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca 23220 tcgggcgcgg atccgccacc atgcgtcccg gcctgccctc ctacctgatc gtgctggctg 23280 tgtgcctgct gtcccacctc ctgtcctccc gttacggtgc tgaggctatc tccgagcccc 23340 tggacaaggc tttccacctc ctgctgaaca cctacggtcg tcctatccgt ttcctgcgcg 23400 agaacaccac ccagtgcacc tacaactcct ccctgcgcaa ctccaccgtc gtccgcgaga 23460 acgctatctc cttcaacttc ttccagtcct acaaccagta ctacgtgttc cacatgcccc 23520 gttgcctgtt cgctggtccc ctggctgagc agttcctgaa ccaggtggac ctgaccgaga 23580 ctctcgagcg ttaccagcag cgtctgaaca cttacgctct ggtgtccaag gacctggctt 23640 cctaccgttc cttcagccag cagctgaagg ctcaggactc cctgggcgag cagcccacca 23700 ctgtgcctcc ccctatcgac ctgtccatcc cccacgtgtg gatgcccccc cagaccactc 23760 ctcacggctg gaccgagtcc cacaccacct ccggactgca ccgtccccac ttcaaccaga 23820 cctgcatcct gttcgacggt cacgacctgc tgttctccac cgtgaccccc tgcctgcacc 23880 agggcttcta cctcatcgac gagctgcgtt acgtgaagat caccctgacc gaggatttct 23940 tcgtggtcac cgtgtccatc gacgacgaca cccccatgct gctgatcttc ggtcacctcc 24000 cccgtgtgct gttcaaggct ccctaccagc gtgacaactt catcctgcgt cagaccgaga 24060 agcacgagct gctggtgctg gtcaagaagg accagctgaa ccgtcactct tacctgaagg 24120 accccgactt cctggacgct gctctggact tcaactacct ggacctgtcc gctctgctga 24180 ggaactcctt ccaccgttac gctgtggacg tgctgaagtc cggtcgttgc cagatgctgg 24240 accgtcgtac cgtcgagatg gctttcgctt acgccctggc tctgttcgct gctgctcgtc 24300 aagaagaggc tggcgctcag gtgtccgtgc cccgtgctct ggaccgtcag gctgctctgc 24360 tgcagatcca agagttcatg atcacttgcc tgtcccagac cccccctcgt accaccctgc 24420 tgctgtaccc caccgctgtg gacctggcta agcgtgctct gtggaccccc aaccagatca 24480 ccgacatcac ctccctcgtg cgtctggtgt acatcctgtc caagcagaac cagcagcacc 24540 tgatccccca gtgggctctg cgtcagatcg ctgacttcgc tctgaagctg cacaagaccc 24600 acctggcttc attcctcagc gctttcgctc gccaagagct gtacctgatg ggttccctgg 24660 tgcactccat gctggtgcac accaccgagc gtcgcgagat cttcatcgtg gaaaccggcc 24720 tgtgctccct ggccgagctg tcccacttca cccagctgct ggctcacccc caccacgagt 24780 acctgtccga cctgtacacc ccctgctcct cttccggtcg tcgtgaccac tccctggaac 24840 gtctgacccg tctgttcccc gacgctaccg tgcctaccac cgtgcctgct gctctgtcca 24900 tcctgtctac catgcagccc tccaccctgg aaaccttccc cgacctgttc tgcctgcctc 24960 tgggcgagtc cttctccgct ctgaccgtgt ccgagcacgt gtcctacgtg gtcaccaacc 25020 agtacctgat caagggcatc tcctaccccg tgtccaccac cgtcgtgggc cagtccctga 25080 tcatcaccca gaccgactcc cagaccaagt gcgagctgac ccgtaacatg cacaccactc 25140 actccatcac cgctgctctg aacatctccc tcgagaactg cgctttctgc cagtccgctc 25200 tgttggagta cgacgacact cagggtgtca tcaacatcat gtacatgcac gactccgacg 25260 acgtgctgtt cgctctggac ccctacaacg aggtggtggt gtcctccccc cgtacccact 25320 acctgatgct gctgaagaac ggcaccgtgc tggaagtgac cgacgtggtg gtggacgcta 25380 ccgaccgtct gctgatgatg tccgtgtacg ctctgtccgc tatcatcggc atctacctgc 25440 tgtaccgtat gctgaagacc tgctaaggcg ccaagctttg tcgagaagta ctagaggatc 25500 ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc 25560 cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct 25620 tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 25680 ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga 25740 tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc 25800 tgctgccacc gctgagcaat aactatcata acccctagga gatccgaacc agataagtga 25860 aatctagttc caaactattt tgtcattttt aattttcgta ttagcttacg acgctacacc 25920 cagttcccat ctattttgtc actcttccct aaataatcct taaaaactcc atttccaccc 25980 ctcccagttc ccaactattt tgtccgccca ca 26012 <210> 45 <211> 29499 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 45 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgcccaccgc tgagcaataa ctatcataac ccccggaata ttaatagatc atggagataa 7200 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 7260 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 7320 cgccaccatg gctgctatgg aagctaacat cttctgcacc ttcgaccaca agctgtctat 7380 cgctgacgtg ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc cccagcgtct 7440 gcacctgatc aagcactacc agctgggcct gcaccagttc gtggaccaca cccgtggtta 7500 cgtgcgtctg cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc gtgtcgaggg 7560 caaccagatc ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc tgaacaccgg 7620 tcccgtgacc tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt tccacggtcc 7680 cctggctcgt gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc cctggatcgt 7740 gcccatgccc ctggctctgg aaatcaacca gcgcctgctg atcatgggcc tgttctccct 7800 ggaccgttcc tacgaagaag tgaaggctgc tgtccagcag ctgcagacca tcaccttccg 7860 tgacgctacc ttcaccatcc ccgaccccgt gatcgaccag cacctcctga tcgacatgaa 7920 gaccgcttgc ctgtccatgt ccatggtggc taacctggct tccgagctga ccatgaccta 7980 cgtccgcaag ctggctttgg aggactcttc catgctgctg gtcaagtgcc aagagctgct 8040 gatgcgtctg gaccgcgagc gttccgtggg cgagcctcgt actcccgctc gtcctcagca 8100 cgtgtccccc gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc tgcgtcagct 8160 ggacgacctg atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc cagacaacaa 8220 gtccgctacc tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa gtactagagg 8280 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 8340 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 8400 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 8460 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 8520 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 8580 ggctgctgcc accgctgagc aataactatc ataacccccg gaatattaat agatcatgga 8640 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 8700 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 8760 ggatcccggt ccgaagcgcg cggaattcaa aggcctgcca ccatggaaat gaacaaggtg 8820 ctgcatcagg atctggtgca ggctacccgt cgtatcctga agctgggccc ctccgagctg 8880 cgtgtgaccg acgctggcct gatctgcaag aaccccaact actccgtgtg cgacgctatg 8940 ctcaagaccg acaccgtgta ctgcgtcgag tacctgctgt cctactggga gtcccgtacc 9000 gaccacgtgc cctgcttcat cttcaagaac accggttgcg ctgtgtccct gtgctgcttc 9060 gtgcgtgctc ccgtgaagct ggtgtcccct gctcgtcacg tgggcgagtt caacgtgctg 9120 aaggtcaacg agtccctgat cgtgaccctg aaggacatcg aggaaatcaa gccctccgct 9180 tacggtgtcc tgactaagtg cgtcgtccgc aagtccaact ccgcttccgt gttcaacatc 9240 gagctgatcg ctttcggtcc cgagaacgag ggcgagtacg agaacctgct gcgcgagctg 9300 tacgctaaga aggctgcttc cacctccctg gctgtgcgta accacgtgac cgtgtcctcc 9360 cactccggtt ccggtccctc cctgtggcgt gctcgtatgt ccgctgctct gacccgtacc 9420 gctggcaagc gctcctccag gactgctagc cctccaccac cacctcctcg tcaccctagc 9480 tgctctccca ctatggtggc tgctggtgga gctgctgctg gtcctagacc tccccctcct 9540 cctatggctg ctggatcctg gcgtctgtgc cgttgcgagg cttgcatggg ccgttgcggt 9600 tgcgcttccg agggcgacgc tgacgaggaa gaggaagagt tgctggctct ggctggcgag 9660 ggcaaggctg ctgctgccgc tgccggtcaa gacgtcggtg gttccgctcg tcgtcccctc 9720 gaggaacacg tgtcccgtcg tcgtggtgtc tccacccacc accgtcaccc cccttcccca 9780 ccttgcgctc cctccctgga acgtaccggt taccgttggg ctccttcctc ctggtggcgc 9840 gctcgttctg gtccttcccg tccccagtcc ggtccctggc tgcctgctcg tttcgctacc 9900 ctgggtcccc tggtcctggc tctgctgttg gtgctggccc tgctgtggcg tggtcacggt 9960 caatccccca gccccacccg ttccgctcac cgtgactaaa agcttgtcga gaagtactag 10020 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 10080 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 10140 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 10200 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 10260 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 10320 gttggctgct gtggctagct ttgtttaact ttaagaagga gatacatcta gaaatattaa 10380 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 10440 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 10500 ccatcgggcg cggatcccgg tccgaagcgc gcggaattca aaggcctacg tcgacgccac 10560 catgtccaac accgctcccg gtcccaccgt ggctaacaag cgtgacgaga agcaccgtca 10620 cgtggtcaac gtggtgctcg agctgcccac cgagatctcc gaggctaccc accccgtgct 10680 ggctaccatg ctgtccaagt acacccgtat gtcctccctg ttcaacgaca agtgcgcttt 10740 caagctggac ctgctgcgta tggtggctgt gtcccgtacc cgtcgctaaa agcttgtcga 10800 gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa 10860 aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa 10920 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 10980 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 11040 tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa 11100 aggaagctga gttggctgct gggtgcctaa tgagtgagct aactcacatt aattgcccgg 11160 aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt 11220 ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata 11280 ccgtcccacc atcgggcgcg gatcccggtc cgaagcgcgc ggaattcgcc accatggacg 11340 ctcgtgctgt ggctaagcgt ccccgtgacc ccgctgacga ggacaacgag ctggtcaccg 11400 ctctgaaggc taagcgtgaa gtgaacacca tctccgtgcg ttacctgtac cacgctgacc 11460 accaggctct gaccgctcgt ttcttcgtgc ccgagggcct ggtcgagttc gaggctcagc 11520 ccggtgctct gctgatccgt atggaaaccg gttgcgactc cccccgtcac ctgtacatct 11580 ccctgtacct gctgggtatc cgtgcttcca acgtgtccgc ttccacccgt tgcctgctcg 11640 agtccgtgta caccgcttcc gctgctcgtg ctgctctgca gtggctggac ctgggtcccc 11700 acctcctgca ccgtcgtctg gaaaccctgg gttgcgtcaa gaccgtgtcc ctgggtatca 11760 cctccctgct gacctgcgtg atgcgcggct acctgtacaa caccctcaag accgaggtgt 11820 tcgctctgat gatccccaag gacatgtacc tgacctggga ggaaacccgc ggtcgtctgc 11880 agtacgtgta cctgatcatc gtgtacgact acgacggtcc cgagactcgt cccggtatct 11940 acgtgctgac ctcctctatc gctcactggc agaccctggt ggacgtggcc cgtggaaagt 12000 tcgctcgtga acgctgctcc ttcgtgaacc gtcgtatcac ccgtccccgt cagatccccc 12060 tgtgcaccgg tgtcatccaa aagctgggct ggtgcctggc tgacgacatc cacacctcat 12120 tcctcgtgca caaggaactg aagctgtccg tcgtgcgtct ggacaacttc tccgtcgagc 12180 tgggcgactt ccgcgagttc gtgcagctgt tgaattttga ccttcttaag cttgcgggag 12240 acgtcgagtc caaccctggg cccatggaat cccgtggtcg tcgttgcccc gagatgatct 12300 ccgtgctggg tcccatctcc ggtcacgtcc tgaaggctgt gttctcccgt ggcgacaccc 12360 ccgtgctgcc ccacgaaact cgtctgctgc agaccggtat ccacgtgcgt gtgtcccagc 12420 cctccctgat cctggtgtcc cagtacaccc ccgactccac cccttgccac cgcggagaca 12480 accagctgca ggtccagcac acctacttca ccggttccga ggtcgagaac gtgtccgtga 12540 acgtgcacaa ccccaccggt cgttccatct gcccctccca agagcccatg tccatctacg 12600 tgtacgctct gcccctgaag atgctgaaca tcccctccat caacgtgcac cactacccct 12660 ccgctgctga gcgcaagcac cgtcacctcc ccgtggctga cgctgtgatc cacgcttccg 12720 gcaagcagat gtggcaggct cgtctgaccg tgtccggcct ggcttggacc cgtcagcaga 12780 accagtggaa ggaacccgac gtgtactaca cctccgcttt cgtgttcccc accaaggacg 12840 tggccctgcg tcacgtcgtg tgcgctcacg aactcgtgtg ctccatggaa aacacccgtg 12900 ctaccaagat gcaagtgatc ggcgaccagt acgtgaaggt gtacctggaa tccttctgcg 12960 aggacgtgcc ctccggcaag ctgttcatgc acgtgaccct gggttccgac gtggaagagg 13020 acctgaccat gacccgtaac ccccagccct tcatgcgtcc ccacgagcgt aacggtttca 13080 ccgtgctgtg ccccaagaac atgatcatca agcccggcaa gatctcccac atcatgctgg 13140 acgtggcctt cacctcccac gagcacttcg gcctgctgtg ccctaagtcc atccccggcc 13200 tgtccatctc cggcaacctg ctgatgaacg gccagcagat cttcctggaa gtgcaggcta 13260 tccgtgaaac cgtcgagctg cgtcagtacg accctgtggc tgctctgttc ttcttcgaca 13320 tcgacctgct gctgcagcgt ggtccccagt actccgagca ccccaccttc accagccagt 13380 accgtatcca gggcaagctg gaataccgtc acacctggga ccgtcacgac gagggtgctg 13440 ctcagggcga cgacgacgtg tggacctccg gttccgactc cgacgaggaa ctggtcacca 13500 ccgagcgcaa gaccccccgt gtgaccggtg gtggtgctat ggctggtgct tccacctccg 13560 ctggtcgcaa gcgcaagtcc gcttcctccg ctaccgcttg caccgctggt gtcatgaccc 13620 gtggtcgcct gaaggctgag tccaccgtgg ctcccgaaga ggacactgac gaggactccg 13680 acaacgagat ccacaacccc gctgtgttca cctggccccc ctggcaggct ggtatcctgg 13740 ctcgtaacct ggtgcccatg gtggctaccg tgcagggcca gaacctgaag taccaagagt 13800 tcttctggga cgccaacgac atctaccgta tcttcgctga gctggaaggc gtgtggcagc 13860 ccgctgctca gcccaagcgt cgtcgtcacc gtcaggacgc tctgcctggt ccctgtatcg 13920 cttccacccc caagaagcac cgcggctaaa agcttgtcga gaagtactag aggatcataa 13980 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 14040 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 14100 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 14160 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 14220 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 14280 gtggctagct ttgtttaact ttaagaagga gatacatcta gacctgcagg ccggaatatt 14340 aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg 14400 ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc 14460 caccatcggg cgcggatccc ggtccgaagc gcgcggaatt cgccaccatg accatggacg 14520 agcagcagcc ccaggctgtg acccccgtgt acgtgggcgg tttcctggct cgttacgacc 14580 agtcccccga cgaggctgag ctgctgctgc cacgtgacgt ggtcgaacac tggctgcacg 14640 ctcagggcca gggacagcct tccctgtccg tggctctgcc cctgaacatc aaccacgacg 14700 acaccgctgt cgtgggtcac gtggccgcta tgcagtccgt gcgtgacggc ctgttctgcc 14760 tgggttgcgt gacctccccc cgtttcctgg aaatcgtgcg tcgtgcttcc gagaagtccg 14820 agctggtgtc ccgtggtccc gtgtccccac tgcagcccga caaggtggtc gagttcctgt 14880 ccggttccta cgctggcctg tccctgtcat cccgtcgttg cgacgacgtc gaggctgcta 14940 cctccctgag cggctccgag actaccccct tcaagcacgt ggccctgtgc tccgtgggtc 15000 gtaggcgtgg aaccctggct gtgtacggtc gtgaccccga gtgggtcacc cagcgtttcc 15060 ccgacctgac cgctgctgac cgtgacggac tgcgtgctca gtggcagcgt tgcggttcca 15120 ccgctgtgga cgcttccggc gaccccttcc gttccgactc ctacggcctg ctgggcaact 15180 ccgtggacgc tctgtacatc cgcgagcgtc tgcccaagct gcgttacgac aagcagctcg 15240 tgggtgtcac cgagcgcgag tcctacgtga aggcttccgt gtcccccgag gctgcttgcg 15300 acatcaaggc tgcttccgct gagcgttctg gcgacagccg ctcccaggct gctactcctg 15360 ctgctggtgc tcgtgtgccc tccagctccc catccccacc tgtcgagcct ccctcccccg 15420 tgcaacctcc tgctctgcct gcttccccct ccgtgctgcc tgctgagtcc agcccctccc 15480 tgtcaccctc tgagcctgct gaggctgcct ccatgtccca ccctctgagc gctgctgtga 15540 ctgctgctac cgctccccct ggtgctactg tggctggtgc ttcccccgct gtgccttccc 15600 tggcttggcc tcacgacggt gtctacctgc ccaaggacgc tttcttctcc ctgctgggcg 15660 cttcccgttc cgctgctccc gtgatgtacc ccggtgctgt ggctgctccc cccagcgctt 15720 cacctgctcc tctgcccctg ccctcctacc ccgcttccta cggtgctccc gtcgtgggtt 15780 acgaccagct ggctgctcgt cacttcgctg actacgtgga cccccactac cccggctggg 15840 gtcgtcgtta cgagcccgct ccttccctgc acccatccta ccctgtgccc cctcctccat 15900 cacccgctta ctaccgtcgt cgtgactccc ccggtggcat ggacgagcct ccatctggat 15960 gggagcgtta cgacggttcc caccgtggcc agtcccaaaa gcagcaccgt cacggtggtt 16020 ccggtggtca caacaagcgt cgcaaggaag ccgctgctgc atcctccagc tccgacgagg 16080 acctgagctt ccccggcgag gctgaacacg gtcgtgctcg caagcgtctg aagtcccacg 16140 tgaactccga cggaggtagc ggaggccacg ctggttccaa ccagcagcag caacagcgct 16200 acgacgagct gcgtgacgct atccacgagc tgaagcgtga cctgttcgct gctcgccagt 16260 cctccaccct gctgtctgct gctctgccag ctgccgcttc ttcctcccct accaccacca 16320 ccgtgtgcac ccctactggc gagctgacct ctggtggtgg cgagactccc accgctctgc 16380 tgtccggtgg tgctaaggtg gccgagcgtg ctcaggctgg tgtcgtgaac gcttcctgcc 16440 gtctggctac cgcttccggt tccgaggctg ccaccgctgg tccctctacc gctggttcct 16500 catcctgccc agcttccgtg gtgctggctg ccgctgctgc tcaagccgcc gctgcttcac 16560 agtccccccc aaaggatatg gtggacctga accgtcgtat cttcgtggct gctctgaaca 16620 agctcgagta ataaaagctt gtcgagaagt actagaggat cataatcagc cataccacat 16680 ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata 16740 aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa 16800 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 16860 tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa 16920 gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 16980 taactatcat aacccctagg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga 17040 ggaactatat ccggatctga acaggaggga cagctgatag aaacagaagc cactggagca 17100 cctcaaaaac accatcatac actaaatcag taagttggca gcatcacccg acgcactttg 17160 cgccgaataa atacctgtga cggaagatca cttcgcagaa taaataaatc ctggtgtccc 17220 tgttgatacc gggaagccct gggccaactt ttggcgaaaa tgagacgttg atcggcacgt 17280 aagaggttcc aactttcacc ataatgaaat aagatcacta ccgggcgtat tttttgagtt 17340 atcgagattt tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac 17400 cgttgatata tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca 17460 atgtacctat aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa 17520 aaataagcac aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca 17580 tccggaattc cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc 17640 ttgttacacc gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca 17700 cgacgatttc cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa 17760 cctggcctat ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg 17820 ggtgagtttc accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt 17880 tttcaccatg ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca 17940 ggttcatcat gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca 18000 gtactgcgat gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta 18060 aacgcctggt tgctacgcct gaataagtga taataagcgg atgaatggca gaaattcgaa 18120 agcaaattcg acccggtcgt cggttcaggg cagggtcgtt aaatagccgc ttatgtctat 18180 tgctggttta ccggtttatt gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc 18240 tgaggccagt ttgctcaggc tctccccgtg gaggtaataa ttgacgatat gatcatttat 18300 tctgcctccc agctgacatt catccggggt cagcaccgtt tctgcggact ggctttctac 18360 gtgttccgct tcctttagca gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat 18420 tctgtcagcc gttaagtgtt cctgtgtcac tcaaaattgc tttgagaggc tctaagggct 18480 tctcagtgcg ttacatccct ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa 18540 agccttatat attctttttt ttcttataaa acttaaaacc ttagaggcta tttaagttgc 18600 tgatttatat taattttatt gttcaaacat gagagcttag tacgtgaaac atgagagctt 18660 agtacgttag ccatgagagc ttagtacgtt agccatgagg gtttagttcg ttaaacatga 18720 gagcttagta cgttaaacat gagagcttag tacgtgaaac atgagagctt agtacgtact 18780 atcaacaggt tgaactgctg atcaacagat cctctacgcg gccgcggtac cataacttcg 18840 tatagcatac attatacgaa gttatctggt ttaaacgtac ccgtagtggc tatggcaggg 18900 cttgccgccc cgacgttggc tgcgagccct gggccttcac ccgaacttgg gggttggggt 18960 ggggaaaagg aagaaacgcg ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca 19020 gagtgccagc cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt 19080 tttattctgt ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg 19140 tgtttcagtt agcctccccc atctcccggt accgcatgct atgcatcagc tgctagctta 19200 gcgagcgtcc acagcctggg gaccgtaacg ggagtgagcg ggcaggttca cacgggtctg 19260 cttcagctca gggggcaggc cagcgtagta cttgtccagg tgacgcagca ggggggggtc 19320 cagctggtga cgcaggcaga attccttcac agcgttgtac aggccgtaga acagggtgat 19380 accctcggga gcagcagcgg tggacacggg cagacgcaca gcacggttgg tacgggtagc 19440 ctcgttacgg atagccacca ccacgttgaa cagggagggg ggcaccagct cgaaacccag 19500 cacgtgttcg gtgaagatgg aacgaccgta ggacagacga gtcaggtcgt aaccacggca 19560 caggtcgtcc acgcaagtgt acacagcggg ggaaccgtcg ccgcactcgg agtaaccgcg 19620 catcacggtc atccaacggg gagcggtgtc ggaggacagc agggtcagca gagcacgcag 19680 ctggtcgggg ttgttgtaca gcagggccag ggtgtccagg aaagcgtcgt ccagcagcac 19740 ggagttagca gcctcggggg tcacgggacg gtaacggatc agctgggaca ggggaccgtc 19800 cctacgggtc acgttgacca ggggacgcag ccaggactcg tacttgtcgc cctggaacac 19860 ctctcccagc aggcaacgac gggtcagctc ggggcactca gcgggcacct tctcagccac 19920 ggtgggagcc acggacacgg tagcggagga cacgatgggc agcagcaggc agcaccacag 19980 cagagccacg ggaccggggg agaaggagaa accgcagtcg ggacgacggc acatggtggc 20040 tcgagatccc gggtgatcaa gtcttcgtcg agtgattgta aataaaatgt aatttacagt 20100 atagtatttt aattaatata caaatgattt gataataatt cttatttaac tataatatat 20160 tgtgttgggt tgaattaaag gtccgtatac tagtatcgat tcgcgaccta ctccggaata 20220 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 20280 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 20340 cccaccatcg ggcgcggatc cgccaccatg tcccccaaga acctgacccc cttcctgacc 20400 gctctgtggc tgctgctggg ccactcccgt gtgcctcgtg tgcgtgctga ggaatgctgc 20460 gagttcatca acgtgaacca cccccccgag cgctgctacg acttcaagat gtgcaaccgt 20520 ttcaccgtgg ctctgcgttg ccccgacggc gaagtgtgct actcccccga aaagaccgct 20580 gagatccgtg gtatcgtgac caccatgacc cactccctga cccgtcaggt ggtgcacaac 20640 aagctgacct cttgcaacta caaccccctg tacctcgagg ctgacggtcg tatccgttgc 20700 ggcaaggtca acgacaaggc tcagtacctg ctgggtgctg ctggttccgt gccctaccgt 20760 tggatcaacc tcgagtacga caagatcacc cgtatcgtgg gcctggacca gtacctcgag 20820 tccgtgaaga agcacaagcg tctggacgtg tgccgtgcta agatgggtta catgctgcag 20880 taaaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt 20940 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 21000 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 21060 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 21120 atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc 21180 taacaaagcc cgaaaggaag ctgagttggc tgctgtggct agctttgttt aactttaaga 21240 aggagataca tctagaccgg aatattaata gatcatggag ataattaaaa tgataaccat 21300 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 21360 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgctgcgt 21420 ctgctgctgc gtcaccactt ccactgcctg ctgctgtgcg ctgtgtgggc taccccctgc 21480 ctggcttccc cttggtccac cctgaccgct aaccagaacc cctccccacc ctggtccaag 21540 ctgacctact ccaagcccca cgacgctgct accttctact gccccttcct gtacccatcc 21600 ccccctcgtt ccccactgca gttctccggt ttccagcgtg tgctgaccgg tcccgagtgc 21660 cgtaacgaga ctctgtacct gctgtacaac cgcgagggcc agaccctggt cgagaggtcc 21720 tccacctggg tcaagaaggt catctggtac ttgtccggtc gtaaccagac catcctgcag 21780 cgtatgcccc gtaccgcttc caagccctcc gacggcaacg tgcagatctc cgtcgaggac 21840 gctaagatct tcggtgctca catggtgccc aagcagacca agctgctgcg tttcgtggtc 21900 aacgacggca cccgttacca gatgtgcgtg atgaagctcg agtcctgggc tcacgtgttc 21960 cgtgactact ccgtgtcctt ccaagtgcgc ctgaccttca ccgaggctaa caaccagacc 22020 tacaccttct gcacccaccc caacctgatc gtgtaaaagc ttgtcgagaa gtactagagg 22080 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 22140 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 22200 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 22260 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 22320 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 22380 ggctgctggg tgcctaatga gtgagctaac tcacattaat tgcccggaat attaatagat 22440 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 22500 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 22560 gggcgcggat ccgccaccat gcgtctgtgc cgtgtgtggc tgtccgtgtg cctgtgcgct 22620 gtggtgctgg gccagtgcca gcgtgaaacc gctgagaaga acgactacta ccgtgtgccc 22680 cactactggg acgcttgctc ccgtgctctg cccgaccaga cccgttacaa gtacgtcgag 22740 cagctggtgg acctgaccct gaactaccac tacgacgctt cccacggcct ggacaacttc 22800 gacgtgctga agcgtatcaa cgtgaccgag gtgtccctgc tgatctccga cttccgtcgt 22860 cagaaccgtc gtggtggcac caacaagcgt accaccttca acgctgctgg ttccctggct 22920 ccccacgctc gttccctcga gttctccgtg cgtctgttcg ctaactaaaa gcttgtcgag 22980 aagtactaga ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa 23040 aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac 23100 ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 23160 aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat 23220 catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca aagcccgaaa 23280 ggaagctgag ttggctgctg ccaccgctga gcaataacta tcataacccc cggaatatta 23340 atagatcatg gagataatta aaatgataac catctcgcaa ataaataagt attttactgt 23400 tttcgtaaca gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc 23460 accatcgggc gcggatcccg gtccgaagcg cgcggaattc aaaggcctac cgtcgacgcc 23520 accatggaat cccgtatctg gtgcctggtc gtgtgcgtga acctgtgcat cgtgtgcctg 23580 ggtgctgctg tgtcctcctc ctccacccgt ggcacctccg ctacccactc ccaccactcc 23640 tcccacacca cctccgccgc tcactcccgt tccggttccg tgtcccagcg tgtgacctcc 23700 tcccagaccg tgtcccacgg tgtcaacgag actatctaca acaccaccct gaagtacggc 23760 gacgtcgtgg gtgtcaacac caccaagtac ccctaccgtg tgtgctccat ggctcagggc 23820 accgacctga tccgtttcga gcgtaacatc gtgtgcacct ccatgaagcc catcaacgag 23880 gacctggacg agggtatcat ggtggtgtac aagcgcaaca tcgtggctca caccttcaag 23940 gtccgcgtgt accagaaggt gctgaccttc cgtcgttcct acgcttacat ccacaccact 24000 tacctgctgg gttccaacac cgagtacgtg gcccctccca tgtgggagat ccaccacatc 24060 aactcccact cccagtgcta ctcctcttac tcccgtgtga tcgctggcac cgtgttcgtg 24120 gcttaccacc gtgactccta cgagaacaag accatgcagc tgatgcccga cgactactcc 24180 aacacccact ccacccgtta cgtgaccgtg aaggaccagt ggcactcccg tggttccacc 24240 tggctgtacc gtgaaacctg caacctgaac tgcatggtca ccatcaccac cgctcgttcc 24300 aagtaccctt accacttctt cgctacctcc accggcgacg tggtggacat ctcccccttc 24360 tacaacggta ctaaccgtaa cgcttcctac ttcggcgaga acgctgacaa gttcttcatc 24420 ttccccaact acaccatcgt gtccgacttc ggtcgtccca actccgctct ggaaacccac 24480 cgtctggtgg ctttcttgga gcgtgctgac tccgtgatct cctgggacat ccaggacgag 24540 aagaacgtga cctgccagct gaccttctgg gaggcttccg agcgtaccat ccgttccgag 24600 gctgaggact cctaccactt ctccagcgct aagatgaccg ctaccttcct gtccaagaaa 24660 caagaggtca acatgtccga ctccgccctg gactgcgtgc gtgacgaggc tatcaacaag 24720 ctgcagcaga tcttcaacac ctcctacaac cagacctacg agaagtacgg aaacgtgtcc 24780 gtgttcgaga ctaccggtgg cctggtggtg ttctggcagg gtatcaagca gaagtccctg 24840 gtcgagctgg aacgtctggc taaccgttcc tccctgaacc tgacccacaa ccgtaccaag 24900 cgttccaccg acggcaacaa cgctactcac ctgtccaaca tggaatccgt gcacaacctg 24960 gtgtacgctc agctgcagtt cacctacgac accctgcgcg gttacatcaa ccgtgctctg 25020 gctcagatcg ctgaggcttg gtgcgtggac cagcgtcgta ccctggaagt gttcaaggaa 25080 ctgtccaaga tcaacccctc cgctatcctg tccgccatct acaacaagcc tatcgctgct 25140 cgtttcatgg gcgacgtgct gggcctggct tcctgcgtga ccatcaacca gacttccgtg 25200 aaggtgctgc gtgacatgaa cgtgaaggaa tcccccggtc gttgctactc ccgtcccgtg 25260 gtcatcttca acttcgctaa ctcctcctac gtgcagtacg gccagctggg cgaggacaac 25320 gagatcctgc tgggcaacca ccgtaccgag gaatgccagc tgccctccct gaagatcttc 25380 atcgctggca actccgctta cgaatacgtg gactacctgt tcaagcgcat gatcgacctg 25440 tcctccatct ctaccgtgga ctccatgatc gctctggaca tcgaccccct ggaaaacacc 25500 gacttccgtg tgctggaact gtactcccag aaggaactgc gttccatcaa cgtgttcgac 25560 ctggaagaga tcatgcgcga gttcaactcc tacaagcagc gtgttaagta cgtcgaggac 25620 aaggtggtgg accccctgcc cccctacctg aagggactgg acgacctgat gtccggcctg 25680 ggagctgccg gcaaggctgt gggtgtcgct atcggtgctg tgggtggtgc tgtggcttcc 25740 gtggtcgagg gtgtcgccac cttcctgaag aaccccttcg gtgctttcac catcatcctg 25800 gtggctatcg ctgtggtcat catcatctac ctgatctaca cccgtcagcg tcgtctgtgc 25860 atgcagcccc tgcagaacct gttcccctac ctggtgtccg ctgacggtac taccgtgacc 25920 tccggcaaca ccaaggacac ctccctgcag gctcccccat cctacgagga atccgtctac 25980 aactccggtc gcaagggtcc cggtccccct tcctccgacg cttctaccgc tgctccccca 26040 tacaccaacg agcaggctta ccagatgctg ctggctctcg tgcgtctgga cgctgagcag 26100 cgtgcacagc agaacggcac cgactccctg gacggccaga ccggaaccca ggacaagggc 26160 cagaagccca acctgctgga ccgtctgcgt caccgcaaga acggttaccg tcacctgaag 26220 gactccgacg aggaagagaa cgtctaaggc gcgccaagct tgtcgagaag tactagagat 26280 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 26340 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 26400 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 26460 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 26520 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgggaata 26580 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 26640 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 26700 cccaccatcg ggcgcggatc cgccaccatg cgtcccggcc tgccctccta cctgatcgtg 26760 ctggctgtgt gcctgctgtc ccacctcctg tcctcccgtt acggtgctga ggctatctcc 26820 gagcccctgg acaaggcttt ccacctcctg ctgaacacct acggtcgtcc tatccgtttc 26880 ctgcgcgaga acaccaccca gtgcacctac aactcctccc tgcgcaactc caccgtcgtc 26940 cgcgagaacg ctatctcctt caacttcttc cagtcctaca accagtacta cgtgttccac 27000 atgccccgtt gcctgttcgc tggtcccctg gctgagcagt tcctgaacca ggtggacctg 27060 accgagactc tcgagcgtta ccagcagcgt ctgaacactt acgctctggt gtccaaggac 27120 ctggcttcct accgttcctt cagccagcag ctgaaggctc aggactccct gggcgagcag 27180 cccaccactg tgcctccccc tatcgacctg tccatccccc acgtgtggat gcccccccag 27240 accactcctc acggctggac cgagtcccac accacctccg gactgcaccg tccccacttc 27300 aaccagacct gcatcctgtt cgacggtcac gacctgctgt tctccaccgt gaccccctgc 27360 ctgcaccagg gcttctacct catcgacgag ctgcgttacg tgaagatcac cctgaccgag 27420 gatttcttcg tggtcaccgt gtccatcgac gacgacaccc ccatgctgct gatcttcggt 27480 cacctccccc gtgtgctgtt caaggctccc taccagcgtg acaacttcat cctgcgtcag 27540 accgagaagc acgagctgct ggtgctggtc aagaaggacc agctgaaccg tcactcttac 27600 ctgaaggacc ccgacttcct ggacgctgct ctggacttca actacctgga cctgtccgct 27660 ctgctgagga actccttcca ccgttacgct gtggacgtgc tgaagtccgg tcgttgccag 27720 atgctggacc gtcgtaccgt cgagatggct ttcgcttacg ccctggctct gttcgctgct 27780 gctcgtcaag aagaggctgg cgctcaggtg tccgtgcccc gtgctctgga ccgtcaggct 27840 gctctgctgc agatccaaga gttcatgatc acttgcctgt cccagacccc ccctcgtacc 27900 accctgctgc tgtaccccac cgctgtggac ctggctaagc gtgctctgtg gacccccaac 27960 cagatcaccg acatcacctc cctcgtgcgt ctggtgtaca tcctgtccaa gcagaaccag 28020 cagcacctga tcccccagtg ggctctgcgt cagatcgctg acttcgctct gaagctgcac 28080 aagacccacc tggcttcatt cctcagcgct ttcgctcgcc aagagctgta cctgatgggt 28140 tccctggtgc actccatgct ggtgcacacc accgagcgtc gcgagatctt catcgtggaa 28200 accggcctgt gctccctggc cgagctgtcc cacttcaccc agctgctggc tcacccccac 28260 cacgagtacc tgtccgacct gtacaccccc tgctcctctt ccggtcgtcg tgaccactcc 28320 ctggaacgtc tgacccgtct gttccccgac gctaccgtgc ctaccaccgt gcctgctgct 28380 ctgtccatcc tgtctaccat gcagccctcc accctggaaa ccttccccga cctgttctgc 28440 ctgcctctgg gcgagtcctt ctccgctctg accgtgtccg agcacgtgtc ctacgtggtc 28500 accaaccagt acctgatcaa gggcatctcc taccccgtgt ccaccaccgt cgtgggccag 28560 tccctgatca tcacccagac cgactcccag accaagtgcg agctgacccg taacatgcac 28620 accactcact ccatcaccgc tgctctgaac atctccctcg agaactgcgc tttctgccag 28680 tccgctctgt tggagtacga cgacactcag ggtgtcatca acatcatgta catgcacgac 28740 tccgacgacg tgctgttcgc tctggacccc tacaacgagg tggtggtgtc ctccccccgt 28800 acccactacc tgatgctgct gaagaacggc accgtgctgg aagtgaccga cgtggtggtg 28860 gacgctaccg accgtctgct gatgatgtcc gtgtacgctc tgtccgctat catcggcatc 28920 tacctgctgt accgtatgct gaagacctgc taaggcgcca agctttgtcg agaagtacta 28980 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 29040 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 29100 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 29160 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 29220 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 29280 agttggctgc tgccaccgct gagcaataac tatcataacc cctaggagat ccgaaccaga 29340 taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta gcttacgacg 29400 ctacacccag ttcccatcta ttttgtcact cttccctaaa taatccttaa aaactccatt 29460 tccacccctc ccagttccca actattttgt ccgcccaca 29499 <210> 46 <211> 29499 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 46 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgcccaccgc tgagcaataa ctatcataac ccccggaata ttaatagatc atggagataa 7200 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 7260 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 7320 cgccaccatg gctgctatgg aagctaacat cttctgcacc ttcgaccaca agctgtctat 7380 cgctgacgtg ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc cccagcgtct 7440 gcacctgatc aagcactacc agctgggcct gcaccagttc gtggaccaca cccgtggtta 7500 cgtgcgtctg cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc gtgtcgaggg 7560 caaccagatc ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc tgaacaccgg 7620 tcccgtgacc tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt tccacggtcc 7680 cctggctcgt gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc cctggatcgt 7740 gcccatgccc ctggctctgg aaatcaacca gcgcctgctg atcatgggcc tgttctccct 7800 ggaccgttcc tacgaagaag tgaaggctgc tgtccagcag ctgcagacca tcaccttccg 7860 tgacgctacc ttcaccatcc ccgaccccgt gatcgaccag cacctcctga tcgacatgaa 7920 gaccgcttgc ctgtccatgt ccatggtggc taacctggct tccgagctga ccatgaccta 7980 cgtccgcaag ctggctttgg aggactcttc catgctgctg gtcaagtgcc aagagctgct 8040 gatgcgtctg gaccgcgagc gttccgtggg cgagcctcgt actcccgctc gtcctcagca 8100 cgtgtccccc gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc tgcgtcagct 8160 ggacgacctg atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc cagacaacaa 8220 gtccgctacc tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa gtactagagg 8280 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 8340 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 8400 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 8460 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 8520 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 8580 ggctgctgcc accgctgagc aataactatc ataacccccg gaatattaat agatcatgga 8640 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 8700 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 8760 ggatcccggt ccgaagcgcg cggaattcaa aggcctgcca ccatggaaat gaacaaggtg 8820 ctgcatcagg atctggtgca ggctacccgt cgtatcctga agctgggccc ctccgagctg 8880 cgtgtgaccg acgctggcct gatctgcaag aaccccaact actccgtgtg cgacgctatg 8940 ctcaagaccg acaccgtgta ctgcgtcgag tacctgctgt cctactggga gtcccgtacc 9000 gaccacgtgc cctgcttcat cttcaagaac accggttgcg ctgtgtccct gtgctgcttc 9060 gtgcgtgctc ccgtgaagct ggtgtcccct gctcgtcacg tgggcgagtt caacgtgctg 9120 aaggtcaacg agtccctgat cgtgaccctg aaggacatcg aggaaatcaa gccctccgct 9180 tacggtgtcc tgactaagtg cgtcgtccgc aagtccaact ccgcttccgt gttcaacatc 9240 gagctgatcg ctttcggtcc cgagaacgag ggcgagtacg agaacctgct gcgcgagctg 9300 tacgctaaga aggctgcttc cacctccctg gctgtgcgta accacgtgac cgtgtcctcc 9360 cactccggtt ccggtccctc cctgtggcgt gctcgtatgt ccgctgctct gacccgtacc 9420 gctggcaagc gctcctccag gactgctagc cctccaccac cacctcctcg tcaccctagc 9480 tgctctccca ctatggtggc tgctggtgga gctgctgctg gtcctagacc tccccctcct 9540 cctatggctg ctggatcctg gcgtctgtgc cgttgcgagg cttgcatggg ccgttgcggt 9600 tgcgcttccg agggcgacgc tgacgaggaa gaggaagagt tgctggctct ggctggcgag 9660 ggcaaggctg ctgctgccgc tgccggtcaa gacgtcggtg gttccgctcg tcgtcccctc 9720 gaggaacacg tgtcccgtcg tcgtggtgtc tccacccacc accgtcaccc cccttcccca 9780 ccttgcgctc cctccctgga acgtaccggt taccgttggg ctccttcctc ctggtggcgc 9840 gctcgttctg gtccttcccg tccccagtcc ggtccctggc tgcctgctcg tttcgctacc 9900 ctgggtcccc tggtcctggc tctgctgttg gtgctggccc tgctgtggcg tggtcacggt 9960 caatccccca gccccacccg ttccgctcac cgtgactaaa agcttgtcga gaagtactag 10020 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 10080 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 10140 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 10200 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 10260 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 10320 gttggctgct gtggctagct ttgtttaact ttaagaagga gatacatcta gaaatattaa 10380 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 10440 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 10500 ccatcgggcg cggatcccgg tccgaagcgc gcggaattca aaggcctacg tcgacgccac 10560 catgtccaac accgctcccg gtcccaccgt ggctaacaag cgtgacgaga agcaccgtca 10620 cgtggtcaac gtggtgctcg agctgcccac cgagatctcc gaggctaccc accccgtgct 10680 ggctaccatg ctgtccaagt acacccgtat gtcctccctg ttcaacgaca agtgcgcttt 10740 caagctggac ctgctgcgta tggtggctgt gtcccgtacc cgtcgctaaa agcttgtcga 10800 gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa 10860 aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa 10920 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 10980 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 11040 tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa 11100 aggaagctga gttggctgct gggtgcctaa tgagtgagct aactcacatt aattgcccgg 11160 aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt 11220 ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata 11280 ccgtcccacc atcgggcgcg gatcccggtc cgaagcgcgc ggaattcgcc accatggacg 11340 ctcgtgctgt ggctaagcgt ccccgtgacc ccgctgacga ggacaacgag ctggtcaccg 11400 ctctgaaggc taagcgtgaa gtgaacacca tctccgtgcg ttacctgtac cacgctgacc 11460 accaggctct gaccgctcgt ttcttcgtgc ccgagggcct ggtcgagttc gaggctcagc 11520 ccggtgctct gctgatccgt atggaaaccg gttgcgactc cccccgtcac ctgtacatct 11580 ccctgtacct gctgggtatc cgtgcttcca acgtgtccgc ttccacccgt tgcctgctcg 11640 agtccgtgta caccgcttcc gctgctcgtg ctgctctgca gtggctggac ctgggtcccc 11700 acctcctgca ccgtcgtctg gaaaccctgg gttgcgtcaa gaccgtgtcc ctgggtatca 11760 cctccctgct gacctgcgtg atgcgcggct acctgtacaa caccctcaag accgaggtgt 11820 tcgctctgat gatccccaag gacatgtacc tgacctggga ggaaacccgc ggtcgtctgc 11880 agtacgtgta cctgatcatc gtgtacgact acgacggtcc cgagactcgt cccggtatct 11940 acgtgctgac ctcctctatc gctcactggc agaccctggt ggacgtggcc cgtggaaagt 12000 tcgctcgtga acgctgctcc ttcgtgaacc gtcgtatcac ccgtccccgt cagatccccc 12060 tgtgcaccgg tgtcatccaa aagctgggct ggtgcctggc tgacgacatc cacacctcat 12120 tcctcgtgca caaggaactg aagctgtccg tcgtgcgtct ggacaacttc tccgtcgagc 12180 tgggcgactt ccgcgagttc gtgcagctgt tgaattttga ccttcttaag cttgcgggag 12240 acgtcgagtc caaccctggg cccatggaat cccgtggtcg tcgttgcccc gagatgatct 12300 ccgtgctggg tcccatctcc ggtcacgtcc tgaaggctgt gttctcccgt ggcgacaccc 12360 ccgtgctgcc ccacgaaact cgtctgctgc agaccggtat ccacgtgcgt gtgtcccagc 12420 cctccctgat cctggtgtcc cagtacaccc ccgactccac cccttgccac cgcggagaca 12480 accagctgca ggtccagcac acctacttca ccggttccga ggtcgagaac gtgtccgtga 12540 acgtgcacaa ccccaccggt cgttccatct gcccctccca agagcccatg tccatctacg 12600 tgtacgctct gcccctgaag atgctgaaca tcccctccat caacgtgcac cactacccct 12660 ccgctgctga gcgcaagcac cgtcacctcc ccgtggctga cgctgtgatc cacgcttccg 12720 gcaagcagat gtggcaggct cgtctgaccg tgtccggcct ggcttggacc cgtcagcaga 12780 accagtggaa ggaacccgac gtgtactaca cctccgcttt cgtgttcccc accaaggacg 12840 tggccctgcg tcacgtcgtg tgcgctcacg aactcgtgtg ctccatggaa aacacccgtg 12900 ctaccaagat gcaagtgatc ggcgaccagt acgtgaaggt gtacctggaa tccttctgcg 12960 aggacgtgcc ctccggcaag ctgttcatgc acgtgaccct gggttccgac gtggaagagg 13020 acctgaccat gacccgtaac ccccagccct tcatgcgtcc ccacgagcgt aacggtttca 13080 ccgtgctgtg ccccaagaac atgatcatca agcccggcaa gatctcccac atcatgctgg 13140 acgtggcctt cacctcccac gagcacttcg gcctgctgtg ccctaagtcc atccccggcc 13200 tgtccatctc cggcaacctg ctgatgaacg gccagcagat cttcctggaa gtgcaggcta 13260 tccgtgaaac cgtcgagctg cgtcagtacg accctgtggc tgctctgttc ttcttcgaca 13320 tcgacctgct gctgcagcgt ggtccccagt actccgagca ccccaccttc accagccagt 13380 accgtatcca gggcaagctg gaataccgtc acacctggga ccgtcacgac gagggtgctg 13440 ctcagggcga cgacgacgtg tggacctccg gttccgactc cgacgaggaa ctggtcacca 13500 ccgagcgcaa gaccccccgt gtgaccggtg gtggtgctat ggctggtgct tccacctccg 13560 ctggtcgcaa gcgcaagtcc gcttcctccg ctaccgcttg caccgctggt gtcatgaccc 13620 gtggtcgcct gaaggctgag tccaccgtgg ctcccgaaga ggacactgac gaggactccg 13680 acaacgagat ccacaacccc gctgtgttca cctggccccc ctggcaggct ggtatcctgg 13740 ctcgtaacct ggtgcccatg gtggctaccg tgcagggcca gaacctgaag taccaagagt 13800 tcttctggga cgccaacgac atctaccgta tcttcgctga gctggaaggc gtgtggcagc 13860 ccgctgctca gcccaagcgt cgtcgtcacc gtcaggacgc tctgcctggt ccctgtatcg 13920 cttccacccc caagaagcac cgcggctaaa agcttgtcga gaagtactag aggatcataa 13980 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 14040 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 14100 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 14160 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 14220 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 14280 gtggctagct ttgtttaact ttaagaagga gatacatcta gacctgcagg ccggaatatt 14340 aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg 14400 ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc 14460 caccatcggg cgcggatccc ggtccgaagc gcgcggaatt cgccaccatg accatggacg 14520 agcagcagcc ccaggctgtg acccccgtgt acgtgggcgg tttcctggct cgttacgacc 14580 agtcccccga cgaggctgag ctgctgctgc cacgtgacgt ggtcgaacac tggctgcacg 14640 ctcagggcca gggacagcct tccctgtccg tggctctgcc cctgaacatc aaccacgacg 14700 acaccgctgt cgtgggtcac gtggccgcta tgcagtccgt gcgtgacggc ctgttctgcc 14760 tgggttgcgt gacctccccc cgtttcctgg aaatcgtgcg tcgtgcttcc gagaagtccg 14820 agctggtgtc ccgtggtccc gtgtccccac tgcagcccga caaggtggtc gagttcctgt 14880 ccggttccta cgctggcctg tccctgtcat cccgtcgttg cgacgacgtc gaggctgcta 14940 cctccctgag cggctccgag actaccccct tcaagcacgt ggccctgtgc tccgtgggtc 15000 gtaggcgtgg aaccctggct gtgtacggtc gtgaccccga gtgggtcacc cagcgtttcc 15060 ccgacctgac cgctgctgac cgtgacggac tgcgtgctca gtggcagcgt tgcggttcca 15120 ccgctgtgga cgcttccggc gaccccttcc gttccgactc ctacggcctg ctgggcaact 15180 ccgtggacgc tctgtacatc cgcgagcgtc tgcccaagct gcgttacgac aagcagctcg 15240 tgggtgtcac cgagcgcgag tcctacgtga aggcttccgt gtcccccgag gctgcttgcg 15300 acatcaaggc tgcttccgct gagcgttctg gcgacagccg ctcccaggct gctactcctg 15360 ctgctggtgc tcgtgtgccc tccagctccc catccccacc tgtcgagcct ccctcccccg 15420 tgcaacctcc tgctctgcct gcttccccct ccgtgctgcc tgctgagtcc agcccctccc 15480 tgtcaccctc tgagcctgct gaggctgcct ccatgtccca ccctctgagc gctgctgtga 15540 ctgctgctac cgctccccct ggtgctactg tggctggtgc ttcccccgct gtgccttccc 15600 tggcttggcc tcacgacggt gtctacctgc ccaaggacgc tttcttctcc ctgctgggcg 15660 cttcccgttc cgctgctccc gtgatgtacc ccggtgctgt ggctgctccc cccagcgctt 15720 cacctgctcc tctgcccctg ccctcctacc ccgcttccta cggtgctccc gtcgtgggtt 15780 acgaccagct ggctgctcgt cacttcgctg actacgtgga cccccactac cccggctggg 15840 gtcgtcgtta cgagcccgct ccttccctgc acccatccta ccctgtgccc cctcctccat 15900 cacccgctta ctaccgtcgt cgtgactccc ccggtggcat ggacgagcct ccatctggat 15960 gggagcgtta cgacggttcc caccgtggcc agtcccaaaa gcagcaccgt cacggtggtt 16020 ccggtggtca caacaagcgt cgcaaggaag ccgctgctgc atcctccagc tccgacgagg 16080 acctgagctt ccccggcgag gctgaacacg gtcgtgctcg caagcgtctg aagtcccacg 16140 tgaactccga cggaggtagc ggaggccacg ctggttccaa ccagcagcag caacagcgct 16200 acgacgagct gcgtgacgct atccacgagc tgaagcgtga cctgttcgct gctcgccagt 16260 cctccaccct gctgtctgct gctctgccag ctgccgcttc ttcctcccct accaccacca 16320 ccgtgtgcac ccctactggc gagctgacct ctggtggtgg cgagactccc accgctctgc 16380 tgtccggtgg tgctaaggtg gccgagcgtg ctcaggctgg tgtcgtgaac gcttcctgcc 16440 gtctggctac cgcttccggt tccgaggctg ccaccgctgg tccctctacc gctggttcct 16500 catcctgccc agcttccgtg gtgctggctg ccgctgctgc tcaagccgcc gctgcttcac 16560 agtccccccc aaaggatatg gtggacctga accgtcgtat cttcgtggct gctctgaaca 16620 agctcgagta ataaaagctt gtcgagaagt actagaggat cataatcagc cataccacat 16680 ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata 16740 aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa 16800 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 16860 tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa 16920 gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 16980 taactatcat aacccctagg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga 17040 ggaactatat ccggatctga acaggaggga cagctgatag aaacagaagc cactggagca 17100 cctcaaaaac accatcatac actaaatcag taagttggca gcatcacccg acgcactttg 17160 cgccgaataa atacctgtga cggaagatca cttcgcagaa taaataaatc ctggtgtccc 17220 tgttgatacc gggaagccct gggccaactt ttggcgaaaa tgagacgttg atcggcacgt 17280 aagaggttcc aactttcacc ataatgaaat aagatcacta ccgggcgtat tttttgagtt 17340 atcgagattt tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac 17400 cgttgatata tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca 17460 atgtacctat aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa 17520 aaataagcac aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca 17580 tccggaattc cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc 17640 ttgttacacc gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca 17700 cgacgatttc cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa 17760 cctggcctat ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg 17820 ggtgagtttc accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt 17880 tttcaccatg ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca 17940 ggttcatcat gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca 18000 gtactgcgat gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta 18060 aacgcctggt tgctacgcct gaataagtga taataagcgg atgaatggca gaaattcgaa 18120 agcaaattcg acccggtcgt cggttcaggg cagggtcgtt aaatagccgc ttatgtctat 18180 tgctggttta ccggtttatt gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc 18240 tgaggccagt ttgctcaggc tctccccgtg gaggtaataa ttgacgatat gatcatttat 18300 tctgcctccc agctgacatt catccggggt cagcaccgtt tctgcggact ggctttctac 18360 gtgttccgct tcctttagca gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat 18420 tctgtcagcc gttaagtgtt cctgtgtcac tcaaaattgc tttgagaggc tctaagggct 18480 tctcagtgcg ttacatccct ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa 18540 agccttatat attctttttt ttcttataaa acttaaaacc ttagaggcta tttaagttgc 18600 tgatttatat taattttatt gttcaaacat gagagcttag tacgtgaaac atgagagctt 18660 agtacgttag ccatgagagc ttagtacgtt agccatgagg gtttagttcg ttaaacatga 18720 gagcttagta cgttaaacat gagagcttag tacgtgaaac atgagagctt agtacgtact 18780 atcaacaggt tgaactgctg atcaacagat cctctacgcg gccgcggtac cataacttcg 18840 tatagcatac attatacgaa gttatctggt ttaaacgtac ccgtagtggc tatggcaggg 18900 cttgccgccc cgacgttggc tgcgagccct gggccttcac ccgaacttgg gggttggggt 18960 ggggaaaagg aagaaacgcg ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca 19020 gagtgccagc cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt 19080 tttattctgt ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg 19140 tgtttcagtt agcctccccc atctcccggt accgcatgct atgcatcagc tgctagctta 19200 gcgagcgtcc acagcctggg gaccgtaacg ggagtgagcg ggcaggttca cacgggtctg 19260 cttcagctca gggggcaggc cagcgtagta cttgtccagg tgacgcagca ggggggggtc 19320 cagctggtga cgcaggcaga attccttcac agcgttgtac aggccgtaga acagggtgat 19380 accctcggga gcagcagcgg tggacacggg cagacgcaca gcacggttgg tacgggtagc 19440 ctcgttacgg atagccacca ccacgttgaa cagggagggg ggcaccagct cgaaacccag 19500 cacgtgttcg gtgaagatgg aacgaccgta ggacagacga gtcaggtcgt aaccacggca 19560 caggtcgtcc acgcaagtgt acacagcggg ggaaccgtcg ccgcactcgg agtaaccgcg 19620 catcacggtc atccaacggg gagcggtgtc ggaggacagc agggtcagca gagcacgcag 19680 ctggtcgggg ttgttgtaca gcagggccag ggtgtccagg aaagcgtcgt ccagcagcac 19740 ggagttagca gcctcggggg tcacgggacg gtaacggatc agctgggaca ggggaccgtc 19800 cctacgggtc acgttgacca ggggacgcag ccaggactcg tacttgtcgc cctggaacac 19860 ctctcccagc aggcaacgac gggtcagctc ggggcactca gcgggcacct tctcagccac 19920 ggtgggagcc acggacacgg tagcggagga cacgatgggc agcagcaggc agcaccacag 19980 cagagccacg ggaccggggg agaaggagaa accgcagtcg ggacgacggc acatggtggc 20040 tcgagatccc gggtgatcaa gtcttcgtcg agtgattgta aataaaatgt aatttacagt 20100 atagtatttt aattaatata caaatgattt gataataatt cttatttaac tataatatat 20160 tgtgttgggt tgaattaaag gtccgtatac tagtatcgat tcgcgaccta ctccggaata 20220 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 20280 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 20340 cccaccatcg ggcgcggatc cgccaccatg aactccaagg acctgacccc cttcctgacc 20400 accctgtggc tgctgctgga ccactcccgt gtgcctcgtg tgcgtgctga ggaatgctgc 20460 gaagtgatca acgtgaacca cccccccgag cgctgctacg acttcaagat gtgcaacctg 20520 ttcaccgtgg ctctgcgttg ccccgacggc gaagtgtgct actcccccga aaagaccgct 20580 gagatccgtg gtatcgtgac caccatgacc cactccctga cccgtcaagt gatccacaac 20640 aagctgacca gctgcaacta caaccccctg tacctcgagg ctgacggtcg tatccgttgc 20700 ggcaaggtgt ccgacaaggc tcagtacctg ctgggtgctg ctggttccgt gccctaccgt 20760 tggatcaacc tcgagtacga caagatcacc cgtatcgtgg gcctggacca gtacctcgag 20820 tccgtgaaga agcacaagcg tctggacgtg tgccgtgcta agatgggtta catgctgcag 20880 taaaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt 20940 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 21000 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 21060 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 21120 atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc 21180 taacaaagcc cgaaaggaag ctgagttggc tgctgtggct agctttgttt aactttaaga 21240 aggagataca tctagaccgg aatattaata gatcatggag ataattaaaa tgataaccat 21300 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 21360 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgctgcgt 21420 ctgctgctgc gtcaccactt ccactgcctg ctgctgtgcg ctgtgtgggc taccccctgc 21480 ctggcttccc cttggtccac cctgaccgct aaccagaacc cctccccacc ctggtccaag 21540 ctgacctact ccaagcccca cgacgctgct accttctact gccccttcct gtacccatcc 21600 ccccctcgtt ccccactgca gttctccggt ttccagcgtg tgctgaccgg tcccgagtgc 21660 cgtaacgaga ctctgtacct gctgtacaac cgcgagggcc agaccctggt cgagaggtcc 21720 tccacctggg tcaagaaggt catctggtac ttgtccggtc gtaaccagac catcctgcag 21780 cgtatgcccc gtaccgcttc caagccctcc gacggcaacg tgcagatctc cgtcgaggac 21840 gctaagatct tcggtgctca catggtgccc aagcagacca agctgctgcg tttcgtggtc 21900 aacgacggca cccgttacca gatgtgcgtg atgaagctcg agtcctgggc tcacgtgttc 21960 cgtgactact ccgtgtcctt ccaagtgcgc ctgaccttca ccgaggctaa caaccagacc 22020 tacaccttct gcacccaccc caacctgatc gtgtaaaagc ttgtcgagaa gtactagagg 22080 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 22140 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 22200 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 22260 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 22320 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 22380 ggctgctggg tgcctaatga gtgagctaac tcacattaat tgcccggaat attaatagat 22440 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 22500 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 22560 gggcgcggat ccgccaccat gcgtctgtgc cgtgtgtggc tgtccgtgtg cctgtgcgct 22620 gtggtgctgg gccagtgcca gcgtgaaacc gctgagaaga acgactacta ccgtgtgccc 22680 cactactggg acgcttgctc ccgtgctctg cccgaccaga cccgttacaa gtacgtcgag 22740 cagctggtgg acctgaccct gaactaccac tacgacgctt cccacggcct ggacaacttc 22800 gacgtgctga agcgtatcaa cgtgaccgag gtgtccctgc tgatctccga cttccgtcgt 22860 cagaaccgtc gtggtggcac caacaagcgt accaccttca acgctgctgg ttccctggct 22920 ccccacgctc gttccctcga gttctccgtg cgtctgttcg ctaactaaaa gcttgtcgag 22980 aagtactaga ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa 23040 aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac 23100 ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 23160 aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat 23220 catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca aagcccgaaa 23280 ggaagctgag ttggctgctg ccaccgctga gcaataacta tcataacccc cggaatatta 23340 atagatcatg gagataatta aaatgataac catctcgcaa ataaataagt attttactgt 23400 tttcgtaaca gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc 23460 accatcgggc gcggatcccg gtccgaagcg cgcggaattc aaaggcctac cgtcgacgcc 23520 accatggaat cccgtatctg gtgcctggtc gtgtgcgtga acctgtgcat cgtgtgcctg 23580 ggtgctgctg tgtcctcctc ctccacccgt ggcacctccg ctacccactc ccaccactcc 23640 tcccacacca cctccgccgc tcactcccgt tccggttccg tgtcccagcg tgtgacctcc 23700 tcccagaccg tgtcccacgg tgtcaacgag actatctaca acaccaccct gaagtacggc 23760 gacgtcgtgg gtgtcaacac caccaagtac ccctaccgtg tgtgctccat ggctcagggc 23820 accgacctga tccgtttcga gcgtaacatc gtgtgcacct ccatgaagcc catcaacgag 23880 gacctggacg agggtatcat ggtggtgtac aagcgcaaca tcgtggctca caccttcaag 23940 gtccgcgtgt accagaaggt gctgaccttc cgtcgttcct acgcttacat ccacaccact 24000 tacctgctgg gttccaacac cgagtacgtg gcccctccca tgtgggagat ccaccacatc 24060 aactcccact cccagtgcta ctcctcttac tcccgtgtga tcgctggcac cgtgttcgtg 24120 gcttaccacc gtgactccta cgagaacaag accatgcagc tgatgcccga cgactactcc 24180 aacacccact ccacccgtta cgtgaccgtg aaggaccagt ggcactcccg tggttccacc 24240 tggctgtacc gtgaaacctg caacctgaac tgcatggtca ccatcaccac cgctcgttcc 24300 aagtaccctt accacttctt cgctacctcc accggcgacg tggtggacat ctcccccttc 24360 tacaacggta ctaaccgtaa cgcttcctac ttcggcgaga acgctgacaa gttcttcatc 24420 ttccccaact acaccatcgt gtccgacttc ggtcgtccca actccgctct ggaaacccac 24480 cgtctggtgg ctttcttgga gcgtgctgac tccgtgatct cctgggacat ccaggacgag 24540 aagaacgtga cctgccagct gaccttctgg gaggcttccg agcgtaccat ccgttccgag 24600 gctgaggact cctaccactt ctccagcgct aagatgaccg ctaccttcct gtccaagaaa 24660 caagaggtca acatgtccga ctccgccctg gactgcgtgc gtgacgaggc tatcaacaag 24720 ctgcagcaga tcttcaacac ctcctacaac cagacctacg agaagtacgg aaacgtgtcc 24780 gtgttcgaga ctaccggtgg cctggtggtg ttctggcagg gtatcaagca gaagtccctg 24840 gtcgagctgg aacgtctggc taaccgttcc tccctgaacc tgacccacaa ccgtaccaag 24900 cgttccaccg acggcaacaa cgctactcac ctgtccaaca tggaatccgt gcacaacctg 24960 gtgtacgctc agctgcagtt cacctacgac accctgcgcg gttacatcaa ccgtgctctg 25020 gctcagatcg ctgaggcttg gtgcgtggac cagcgtcgta ccctggaagt gttcaaggaa 25080 ctgtccaaga tcaacccctc cgctatcctg tccgccatct acaacaagcc tatcgctgct 25140 cgtttcatgg gcgacgtgct gggcctggct tcctgcgtga ccatcaacca gacttccgtg 25200 aaggtgctgc gtgacatgaa cgtgaaggaa tcccccggtc gttgctactc ccgtcccgtg 25260 gtcatcttca acttcgctaa ctcctcctac gtgcagtacg gccagctggg cgaggacaac 25320 gagatcctgc tgggcaacca ccgtaccgag gaatgccagc tgccctccct gaagatcttc 25380 atcgctggca actccgctta cgaatacgtg gactacctgt tcaagcgcat gatcgacctg 25440 tcctccatct ctaccgtgga ctccatgatc gctctggaca tcgaccccct ggaaaacacc 25500 gacttccgtg tgctggaact gtactcccag aaggaactgc gttccatcaa cgtgttcgac 25560 ctggaagaga tcatgcgcga gttcaactcc tacaagcagc gtgttaagta cgtcgaggac 25620 aaggtggtgg accccctgcc cccctacctg aagggactgg acgacctgat gtccggcctg 25680 ggagctgccg gcaaggctgt gggtgtcgct atcggtgctg tgggtggtgc tgtggcttcc 25740 gtggtcgagg gtgtcgccac cttcctgaag aaccccttcg gtgctttcac catcatcctg 25800 gtggctatcg ctgtggtcat catcatctac ctgatctaca cccgtcagcg tcgtctgtgc 25860 atgcagcccc tgcagaacct gttcccctac ctggtgtccg ctgacggtac taccgtgacc 25920 tccggcaaca ccaaggacac ctccctgcag gctcccccat cctacgagga atccgtctac 25980 aactccggtc gcaagggtcc cggtccccct tcctccgacg cttctaccgc tgctccccca 26040 tacaccaacg agcaggctta ccagatgctg ctggctctcg tgcgtctgga cgctgagcag 26100 cgtgcacagc agaacggcac cgactccctg gacggccaga ccggaaccca ggacaagggc 26160 cagaagccca acctgctgga ccgtctgcgt caccgcaaga acggttaccg tcacctgaag 26220 gactccgacg aggaagagaa cgtctaaggc gcgccaagct tgtcgagaag tactagagat 26280 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 26340 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 26400 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 26460 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 26520 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgggaata 26580 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 26640 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 26700 cccaccatcg ggcgcggatc cgccaccatg cgtcccggcc tgccctccta cctgatcgtg 26760 ctggctgtgt gcctgctgtc ccacctcctg tcctcccgtt acggtgctga ggctatctcc 26820 gagcccctgg acaaggcttt ccacctcctg ctgaacacct acggtcgtcc tatccgtttc 26880 ctgcgcgaga acaccaccca gtgcacctac aactcctccc tgcgcaactc caccgtcgtc 26940 cgcgagaacg ctatctcctt caacttcttc cagtcctaca accagtacta cgtgttccac 27000 atgccccgtt gcctgttcgc tggtcccctg gctgagcagt tcctgaacca ggtggacctg 27060 accgagactc tcgagcgtta ccagcagcgt ctgaacactt acgctctggt gtccaaggac 27120 ctggcttcct accgttcctt cagccagcag ctgaaggctc aggactccct gggcgagcag 27180 cccaccactg tgcctccccc tatcgacctg tccatccccc acgtgtggat gcccccccag 27240 accactcctc acggctggac cgagtcccac accacctccg gactgcaccg tccccacttc 27300 aaccagacct gcatcctgtt cgacggtcac gacctgctgt tctccaccgt gaccccctgc 27360 ctgcaccagg gcttctacct catcgacgag ctgcgttacg tgaagatcac cctgaccgag 27420 gatttcttcg tggtcaccgt gtccatcgac gacgacaccc ccatgctgct gatcttcggt 27480 cacctccccc gtgtgctgtt caaggctccc taccagcgtg acaacttcat cctgcgtcag 27540 accgagaagc acgagctgct ggtgctggtc aagaaggacc agctgaaccg tcactcttac 27600 ctgaaggacc ccgacttcct ggacgctgct ctggacttca actacctgga cctgtccgct 27660 ctgctgagga actccttcca ccgttacgct gtggacgtgc tgaagtccgg tcgttgccag 27720 atgctggacc gtcgtaccgt cgagatggct ttcgcttacg ccctggctct gttcgctgct 27780 gctcgtcaag aagaggctgg cgctcaggtg tccgtgcccc gtgctctgga ccgtcaggct 27840 gctctgctgc agatccaaga gttcatgatc acttgcctgt cccagacccc ccctcgtacc 27900 accctgctgc tgtaccccac cgctgtggac ctggctaagc gtgctctgtg gacccccaac 27960 cagatcaccg acatcacctc cctcgtgcgt ctggtgtaca tcctgtccaa gcagaaccag 28020 cagcacctga tcccccagtg ggctctgcgt cagatcgctg acttcgctct gaagctgcac 28080 aagacccacc tggcttcatt cctcagcgct ttcgctcgcc aagagctgta cctgatgggt 28140 tccctggtgc actccatgct ggtgcacacc accgagcgtc gcgagatctt catcgtggaa 28200 accggcctgt gctccctggc cgagctgtcc cacttcaccc agctgctggc tcacccccac 28260 cacgagtacc tgtccgacct gtacaccccc tgctcctctt ccggtcgtcg tgaccactcc 28320 ctggaacgtc tgacccgtct gttccccgac gctaccgtgc ctaccaccgt gcctgctgct 28380 ctgtccatcc tgtctaccat gcagccctcc accctggaaa ccttccccga cctgttctgc 28440 ctgcctctgg gcgagtcctt ctccgctctg accgtgtccg agcacgtgtc ctacgtggtc 28500 accaaccagt acctgatcaa gggcatctcc taccccgtgt ccaccaccgt cgtgggccag 28560 tccctgatca tcacccagac cgactcccag accaagtgcg agctgacccg taacatgcac 28620 accactcact ccatcaccgc tgctctgaac atctccctcg agaactgcgc tttctgccag 28680 tccgctctgt tggagtacga cgacactcag ggtgtcatca acatcatgta catgcacgac 28740 tccgacgacg tgctgttcgc tctggacccc tacaacgagg tggtggtgtc ctccccccgt 28800 acccactacc tgatgctgct gaagaacggc accgtgctgg aagtgaccga cgtggtggtg 28860 gacgctaccg accgtctgct gatgatgtcc gtgtacgctc tgtccgctat catcggcatc 28920 tacctgctgt accgtatgct gaagacctgc taaggcgcca agctttgtcg agaagtacta 28980 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 29040 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 29100 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 29160 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 29220 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 29280 agttggctgc tgccaccgct gagcaataac tatcataacc cctaggagat ccgaaccaga 29340 taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta gcttacgacg 29400 ctacacccag ttcccatcta ttttgtcact cttccctaaa taatccttaa aaactccatt 29460 tccacccctc ccagttccca actattttgt ccgcccaca 29499 <210> 47 <211> 29520 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 47 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgcccaccgc tgagcaataa ctatcataac ccccggaata ttaatagatc atggagataa 7200 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 7260 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 7320 cgccaccatg gctgctatgg aagctaacat cttctgcacc ttcgaccaca agctgtctat 7380 cgctgacgtg ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc cccagcgtct 7440 gcacctgatc aagcactacc agctgggcct gcaccagttc gtggaccaca cccgtggtta 7500 cgtgcgtctg cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc gtgtcgaggg 7560 caaccagatc ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc tgaacaccgg 7620 tcccgtgacc tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt tccacggtcc 7680 cctggctcgt gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc cctggatcgt 7740 gcccatgccc ctggctctgg aaatcaacca gcgcctgctg atcatgggcc tgttctccct 7800 ggaccgttcc tacgaagaag tgaaggctgc tgtccagcag ctgcagacca tcaccttccg 7860 tgacgctacc ttcaccatcc ccgaccccgt gatcgaccag cacctcctga tcgacatgaa 7920 gaccgcttgc ctgtccatgt ccatggtggc taacctggct tccgagctga ccatgaccta 7980 cgtccgcaag ctggctttgg aggactcttc catgctgctg gtcaagtgcc aagagctgct 8040 gatgcgtctg gaccgcgagc gttccgtggg cgagcctcgt actcccgctc gtcctcagca 8100 cgtgtccccc gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc tgcgtcagct 8160 ggacgacctg atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc cagacaacaa 8220 gtccgctacc tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa gtactagagg 8280 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 8340 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 8400 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 8460 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 8520 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 8580 ggctgctgcc accgctgagc aataactatc ataacccccg gaatattaat agatcatgga 8640 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 8700 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 8760 ggatcccggt ccgaagcgcg cggaattcaa aggcctgcca ccatggaaat gaacaaggtg 8820 ctgcatcagg atctggtgca ggctacccgt cgtatcctga agctgggccc ctccgagctg 8880 cgtgtgaccg acgctggcct gatctgcaag aaccccaact actccgtgtg cgacgctatg 8940 ctcaagaccg acaccgtgta ctgcgtcgag tacctgctgt cctactggga gtcccgtacc 9000 gaccacgtgc cctgcttcat cttcaagaac accggttgcg ctgtgtccct gtgctgcttc 9060 gtgcgtgctc ccgtgaagct ggtgtcccct gctcgtcacg tgggcgagtt caacgtgctg 9120 aaggtcaacg agtccctgat cgtgaccctg aaggacatcg aggaaatcaa gccctccgct 9180 tacggtgtcc tgactaagtg cgtcgtccgc aagtccaact ccgcttccgt gttcaacatc 9240 gagctgatcg ctttcggtcc cgagaacgag ggcgagtacg agaacctgct gcgcgagctg 9300 tacgctaaga aggctgcttc cacctccctg gctgtgcgta accacgtgac cgtgtcctcc 9360 cactccggtt ccggtccctc cctgtggcgt gctcgtatgt ccgctgctct gacccgtacc 9420 gctggcaagc gctcctccag gactgctagc cctccaccac cacctcctcg tcaccctagc 9480 tgctctccca ctatggtggc tgctggtgga gctgctgctg gtcctagacc tccccctcct 9540 cctatggctg ctggatcctg gcgtctgtgc cgttgcgagg cttgcatggg ccgttgcggt 9600 tgcgcttccg agggcgacgc tgacgaggaa gaggaagagt tgctggctct ggctggcgag 9660 ggcaaggctg ctgctgccgc tgccggtcaa gacgtcggtg gttccgctcg tcgtcccctc 9720 gaggaacacg tgtcccgtcg tcgtggtgtc tccacccacc accgtcaccc cccttcccca 9780 ccttgcgctc cctccctgga acgtaccggt taccgttggg ctccttcctc ctggtggcgc 9840 gctcgttctg gtccttcccg tccccagtcc ggtccctggc tgcctgctcg tttcgctacc 9900 ctgggtcccc tggtcctggc tctgctgttg gtgctggccc tgctgtggcg tggtcacggt 9960 caatccccca gccccacccg ttccgctcac cgtgactaaa agcttgtcga gaagtactag 10020 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 10080 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 10140 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 10200 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 10260 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 10320 gttggctgct gtggctagct ttgtttaact ttaagaagga gatacatcta gaaatattaa 10380 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 10440 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 10500 ccatcgggcg cggatcccgg tccgaagcgc gcggaattca aaggcctacg tcgacgccac 10560 catgtccaac accgctcccg gtcccaccgt ggctaacaag cgtgacgaga agcaccgtca 10620 cgtggtcaac gtggtgctcg agctgcccac cgagatctcc gaggctaccc accccgtgct 10680 ggctaccatg ctgtccaagt acacccgtat gtcctccctg ttcaacgaca agtgcgcttt 10740 caagctggac ctgctgcgta tggtggctgt gtcccgtacc cgtcgctaaa agcttgtcga 10800 gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa 10860 aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa 10920 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 10980 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 11040 tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa 11100 aggaagctga gttggctgct gggtgcctaa tgagtgagct aactcacatt aattgcccgg 11160 aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt 11220 ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata 11280 ccgtcccacc atcgggcgcg gatcccggtc cgaagcgcgc ggaattcgcc accatggacg 11340 ctcgtgctgt ggctaagcgt ccccgtgacc ccgctgacga ggacaacgag ctggtcaccg 11400 ctctgaaggc taagcgtgaa gtgaacacca tctccgtgcg ttacctgtac cacgctgacc 11460 accaggctct gaccgctcgt ttcttcgtgc ccgagggcct ggtcgagttc gaggctcagc 11520 ccggtgctct gctgatccgt atggaaaccg gttgcgactc cccccgtcac ctgtacatct 11580 ccctgtacct gctgggtatc cgtgcttcca acgtgtccgc ttccacccgt tgcctgctcg 11640 agtccgtgta caccgcttcc gctgctcgtg ctgctctgca gtggctggac ctgggtcccc 11700 acctcctgca ccgtcgtctg gaaaccctgg gttgcgtcaa gaccgtgtcc ctgggtatca 11760 cctccctgct gacctgcgtg atgcgcggct acctgtacaa caccctcaag accgaggtgt 11820 tcgctctgat gatccccaag gacatgtacc tgacctggga ggaaacccgc ggtcgtctgc 11880 agtacgtgta cctgatcatc gtgtacgact acgacggtcc cgagactcgt cccggtatct 11940 acgtgctgac ctcctctatc gctcactggc agaccctggt ggacgtggcc cgtggaaagt 12000 tcgctcgtga acgctgctcc ttcgtgaacc gtcgtatcac ccgtccccgt cagatccccc 12060 tgtgcaccgg tgtcatccaa aagctgggct ggtgcctggc tgacgacatc cacacctcat 12120 tcctcgtgca caaggaactg aagctgtccg tcgtgcgtct ggacaacttc tccgtcgagc 12180 tgggcgactt ccgcgagttc gtgcagctgt tgaattttga ccttcttaag cttgcgggag 12240 acgtcgagtc caaccctggg cccatggaat cccgtggtcg tcgttgcccc gagatgatct 12300 ccgtgctggg tcccatctcc ggtcacgtcc tgaaggctgt gttctcccgt ggcgacaccc 12360 ccgtgctgcc ccacgaaact cgtctgctgc agaccggtat ccacgtgcgt gtgtcccagc 12420 cctccctgat cctggtgtcc cagtacaccc ccgactccac cccttgccac cgcggagaca 12480 accagctgca ggtccagcac acctacttca ccggttccga ggtcgagaac gtgtccgtga 12540 acgtgcacaa ccccaccggt cgttccatct gcccctccca agagcccatg tccatctacg 12600 tgtacgctct gcccctgaag atgctgaaca tcccctccat caacgtgcac cactacccct 12660 ccgctgctga gcgcaagcac cgtcacctcc ccgtggctga cgctgtgatc cacgcttccg 12720 gcaagcagat gtggcaggct cgtctgaccg tgtccggcct ggcttggacc cgtcagcaga 12780 accagtggaa ggaacccgac gtgtactaca cctccgcttt cgtgttcccc accaaggacg 12840 tggccctgcg tcacgtcgtg tgcgctcacg aactcgtgtg ctccatggaa aacacccgtg 12900 ctaccaagat gcaagtgatc ggcgaccagt acgtgaaggt gtacctggaa tccttctgcg 12960 aggacgtgcc ctccggcaag ctgttcatgc acgtgaccct gggttccgac gtggaagagg 13020 acctgaccat gacccgtaac ccccagccct tcatgcgtcc ccacgagcgt aacggtttca 13080 ccgtgctgtg ccccaagaac atgatcatca agcccggcaa gatctcccac atcatgctgg 13140 acgtggcctt cacctcccac gagcacttcg gcctgctgtg ccctaagtcc atccccggcc 13200 tgtccatctc cggcaacctg ctgatgaacg gccagcagat cttcctggaa gtgcaggcta 13260 tccgtgaaac cgtcgagctg cgtcagtacg accctgtggc tgctctgttc ttcttcgaca 13320 tcgacctgct gctgcagcgt ggtccccagt actccgagca ccccaccttc accagccagt 13380 accgtatcca gggcaagctg gaataccgtc acacctggga ccgtcacgac gagggtgctg 13440 ctcagggcga cgacgacgtg tggacctccg gttccgactc cgacgaggaa ctggtcacca 13500 ccgagcgcaa gaccccccgt gtgaccggtg gtggtgctat ggctggtgct tccacctccg 13560 ctggtcgcaa gcgcaagtcc gcttcctccg ctaccgcttg caccgctggt gtcatgaccc 13620 gtggtcgcct gaaggctgag tccaccgtgg ctcccgaaga ggacactgac gaggactccg 13680 acaacgagat ccacaacccc gctgtgttca cctggccccc ctggcaggct ggtatcctgg 13740 ctcgtaacct ggtgcccatg gtggctaccg tgcagggcca gaacctgaag taccaagagt 13800 tcttctggga cgccaacgac atctaccgta tcttcgctga gctggaaggc gtgtggcagc 13860 ccgctgctca gcccaagcgt cgtcgtcacc gtcaggacgc tctgcctggt ccctgtatcg 13920 cttccacccc caagaagcac cgcggctaaa agcttgtcga gaagtactag aggatcataa 13980 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 14040 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 14100 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 14160 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 14220 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 14280 gtggctagct ttgtttaact ttaagaagga gatacatcta gacctgcagg ccggaatatt 14340 aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg 14400 ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc 14460 caccatcggg cgcggatccc ggtccgaagc gcgcggaatt cgccaccatg accatggacg 14520 agcagcagcc ccaggctgtg acccccgtgt acgtgggcgg tttcctggct cgttacgacc 14580 agtcccccga cgaggctgag ctgctgctgc cacgtgacgt ggtcgaacac tggctgcacg 14640 ctcagggcca gggacagcct tccctgtccg tggctctgcc cctgaacatc aaccacgacg 14700 acaccgctgt cgtgggtcac gtggccgcta tgcagtccgt gcgtgacggc ctgttctgcc 14760 tgggttgcgt gacctccccc cgtttcctgg aaatcgtgcg tcgtgcttcc gagaagtccg 14820 agctggtgtc ccgtggtccc gtgtccccac tgcagcccga caaggtggtc gagttcctgt 14880 ccggttccta cgctggcctg tccctgtcat cccgtcgttg cgacgacgtc gaggctgcta 14940 cctccctgag cggctccgag actaccccct tcaagcacgt ggccctgtgc tccgtgggtc 15000 gtaggcgtgg aaccctggct gtgtacggtc gtgaccccga gtgggtcacc cagcgtttcc 15060 ccgacctgac cgctgctgac cgtgacggac tgcgtgctca gtggcagcgt tgcggttcca 15120 ccgctgtgga cgcttccggc gaccccttcc gttccgactc ctacggcctg ctgggcaact 15180 ccgtggacgc tctgtacatc cgcgagcgtc tgcccaagct gcgttacgac aagcagctcg 15240 tgggtgtcac cgagcgcgag tcctacgtga aggcttccgt gtcccccgag gctgcttgcg 15300 acatcaaggc tgcttccgct gagcgttctg gcgacagccg ctcccaggct gctactcctg 15360 ctgctggtgc tcgtgtgccc tccagctccc catccccacc tgtcgagcct ccctcccccg 15420 tgcaacctcc tgctctgcct gcttccccct ccgtgctgcc tgctgagtcc agcccctccc 15480 tgtcaccctc tgagcctgct gaggctgcct ccatgtccca ccctctgagc gctgctgtga 15540 ctgctgctac cgctccccct ggtgctactg tggctggtgc ttcccccgct gtgccttccc 15600 tggcttggcc tcacgacggt gtctacctgc ccaaggacgc tttcttctcc ctgctgggcg 15660 cttcccgttc cgctgctccc gtgatgtacc ccggtgctgt ggctgctccc cccagcgctt 15720 cacctgctcc tctgcccctg ccctcctacc ccgcttccta cggtgctccc gtcgtgggtt 15780 acgaccagct ggctgctcgt cacttcgctg actacgtgga cccccactac cccggctggg 15840 gtcgtcgtta cgagcccgct ccttccctgc acccatccta ccctgtgccc cctcctccat 15900 cacccgctta ctaccgtcgt cgtgactccc ccggtggcat ggacgagcct ccatctggat 15960 gggagcgtta cgacggttcc caccgtggcc agtcccaaaa gcagcaccgt cacggtggtt 16020 ccggtggtca caacaagcgt cgcaaggaag ccgctgctgc atcctccagc tccgacgagg 16080 acctgagctt ccccggcgag gctgaacacg gtcgtgctcg caagcgtctg aagtcccacg 16140 tgaactccga cggaggtagc ggaggccacg ctggttccaa ccagcagcag caacagcgct 16200 acgacgagct gcgtgacgct atccacgagc tgaagcgtga cctgttcgct gctcgccagt 16260 cctccaccct gctgtctgct gctctgccag ctgccgcttc ttcctcccct accaccacca 16320 ccgtgtgcac ccctactggc gagctgacct ctggtggtgg cgagactccc accgctctgc 16380 tgtccggtgg tgctaaggtg gccgagcgtg ctcaggctgg tgtcgtgaac gcttcctgcc 16440 gtctggctac cgcttccggt tccgaggctg ccaccgctgg tccctctacc gctggttcct 16500 catcctgccc agcttccgtg gtgctggctg ccgctgctgc tcaagccgcc gctgcttcac 16560 agtccccccc aaaggatatg gtggacctga accgtcgtat cttcgtggct gctctgaaca 16620 agctcgagta ataaaagctt gtcgagaagt actagaggat cataatcagc cataccacat 16680 ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata 16740 aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa 16800 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 16860 tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa 16920 gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 16980 taactatcat aacccctagg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga 17040 ggaactatat ccggatctga acaggaggga cagctgatag aaacagaagc cactggagca 17100 cctcaaaaac accatcatac actaaatcag taagttggca gcatcacccg acgcactttg 17160 cgccgaataa atacctgtga cggaagatca cttcgcagaa taaataaatc ctggtgtccc 17220 tgttgatacc gggaagccct gggccaactt ttggcgaaaa tgagacgttg atcggcacgt 17280 aagaggttcc aactttcacc ataatgaaat aagatcacta ccgggcgtat tttttgagtt 17340 atcgagattt tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac 17400 cgttgatata tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca 17460 atgtacctat aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa 17520 aaataagcac aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca 17580 tccggaattc cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc 17640 ttgttacacc gttttccatg agcaaactga aacgttttca tcgctctgga gtgaatacca 17700 cgacgatttc cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa 17760 cctggcctat ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg 17820 ggtgagtttc accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt 17880 tttcaccatg ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca 17940 ggttcatcat gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca 18000 gtactgcgat gagtggcagg gcggggcgta atttttttaa ggcagttatt ggtgccctta 18060 aacgcctggt tgctacgcct gaataagtga taataagcgg atgaatggca gaaattcgaa 18120 agcaaattcg acccggtcgt cggttcaggg cagggtcgtt aaatagccgc ttatgtctat 18180 tgctggttta ccggtttatt gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc 18240 tgaggccagt ttgctcaggc tctccccgtg gaggtaataa ttgacgatat gatcatttat 18300 tctgcctccc agctgacatt catccggggt cagcaccgtt tctgcggact ggctttctac 18360 gtgttccgct tcctttagca gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat 18420 tctgtcagcc gttaagtgtt cctgtgtcac tcaaaattgc tttgagaggc tctaagggct 18480 tctcagtgcg ttacatccct ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa 18540 agccttatat attctttttt ttcttataaa acttaaaacc ttagaggcta tttaagttgc 18600 tgatttatat taattttatt gttcaaacat gagagcttag tacgtgaaac atgagagctt 18660 agtacgttag ccatgagagc ttagtacgtt agccatgagg gtttagttcg ttaaacatga 18720 gagcttagta cgttaaacat gagagcttag tacgtgaaac atgagagctt agtacgtact 18780 atcaacaggt tgaactgctg atcaacagat cctctacgcg gccgcggtac cataacttcg 18840 tatagcatac attatacgaa gttatctggt ttaaacgtac ccgtagtggc tatggcaggg 18900 cttgccgccc cgacgttggc tgcgagccct gggccttcac ccgaacttgg gggttggggt 18960 ggggaaaagg aagaaacgcg ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca 19020 gagtgccagc cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt 19080 tttattctgt ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg 19140 tgtttcagtt agcctccccc atctcccggt accgcatgct atgcatcagc tgctagctta 19200 gcgagcgtcc acagcctggg gaccgtaacg ggagtgagcg ggcaggttca cacgggtctg 19260 cttcagctca gggggcaggc cagcgtagta cttgtccagg tgacgcagca ggggggggtc 19320 cagctggtga cgcaggcaga attccttcac agcgttgtac aggccgtaga acagggtgat 19380 accctcggga gcagcagcgg tggacacggg cagacgcaca gcacggttgg tacgggtagc 19440 ctcgttacgg atagccacca ccacgttgaa cagggagggg ggcaccagct cgaaacccag 19500 cacgtgttcg gtgaagatgg aacgaccgta ggacagacga gtcaggtcgt aaccacggca 19560 caggtcgtcc acgcaagtgt acacagcggg ggaaccgtcg ccgcactcgg agtaaccgcg 19620 catcacggtc atccaacggg gagcggtgtc ggaggacagc agggtcagca gagcacgcag 19680 ctggtcgggg ttgttgtaca gcagggccag ggtgtccagg aaagcgtcgt ccagcagcac 19740 ggagttagca gcctcggggg tcacgggacg gtaacggatc agctgggaca ggggaccgtc 19800 cctacgggtc acgttgacca ggggacgcag ccaggactcg tacttgtcgc cctggaacac 19860 ctctcccagc aggcaacgac gggtcagctc ggggcactca gcgggcacct tctcagccac 19920 ggtgggagcc acggacacgg tagcggagga cacgatgggc agcagcaggc agcaccacag 19980 cagagccacg ggaccggggg agaaggagaa accgcagtcg ggacgacggc acatggtggc 20040 tcgagatccc gggtgatcaa gtcttcgtcg agtgattgta aataaaatgt aatttacagt 20100 atagtatttt aattaatata caaatgattt gataataatt cttatttaac tataatatat 20160 tgtgttgggt tgaattaaag gtccgtatac tagtatcgat tcgcgaccta ctccggaata 20220 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 20280 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 20340 cccaccatcg ggcgcggatc cgccaccatg aactccaagg acctgacccc cttcctgacc 20400 accctgtggc tgctgctgga ccactcccgt gtgcctcgtg tgcgtgctga ggaatgctgc 20460 gaagtgatca acgtgaacca cccccccgag cgctgctacg acttcaagat gtgcaacctg 20520 ttcaccgtgg ctctgcgttg ccccgacggc gaagtgtgct actcccccga aaagaccgct 20580 gagatccgtg gtatcgtgac caccatgacc cactccctga cccgtcaagt gatccacaac 20640 aagctgacca gctgcaacta caaccccctg tacctcgagg ctgacggtcg tatccgttgc 20700 ggcaaggtgt ccgacaaggc tcagtacctg ctgggtgctg ctggttccgt gccctaccgt 20760 tggatcaacc tcgagtacga caagatcacc cgtatcgtgg gcctggacca gtacctcgag 20820 tccgtgaaga agcacaagcg tctggacgtg tgccgtgcta agatgggtta catgctgcag 20880 taaaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt 20940 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 21000 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 21060 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 21120 atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc 21180 taacaaagcc cgaaaggaag ctgagttggc tgctgtggct agctttgttt aactttaaga 21240 aggagataca tctagaccgg aatattaata gatcatggag ataattaaaa tgataaccat 21300 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 21360 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgctgcgt 21420 ctgctgctgc gtcaccactt ccactgcctg ctgctgtgcg ctgtgtgggc taccccctgc 21480 ctggcttccc cctggttcac cctgaccgct aaccagaacc cctccccacc ctggtccaag 21540 ctgacctacc ccaagcccca cgacgctgct accttctact gccccttcct gtacccatcc 21600 ccacctcgtt ccccatccca gttctccggt ttccagcgtg tgtccaccgg tcccgagtgc 21660 cgtaacgaga ctctgtacct gctgtacaac cgcgagggcc agaccctggt cgagaggtcc 21720 tccacctggg tcaagaaggt catctggtac ttgtccggtc gtaaccagac catcctgcag 21780 cgtatgcccc gtaccgcttc caagccctcc gacggcaacg tgcagatctc cgtcgaggac 21840 gctaagatct tcggtgctca catggtgccc aagcagacca agctgctgcg tttcgtggtc 21900 aacgacggca cccgttacca gatgtgcgtg atgaagctgg aatcctgggc tcacgtgttc 21960 cgtgactact ccgtgtcctt ccaagtgcgc ctgaccttca ccgaggctaa caaccagacc 22020 tacaccttct gcacccaccc caacctgatc gtgtaagtcg acaagcttgt cgagaagtac 22080 tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc 22140 ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 22200 attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 22260 tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 22320 tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc 22380 tgagttggct gctgggtgcc taatgagtga gctaactcac attaattgcc cggaatatta 22440 atagatcatg gagataatta aaatgataac catctcgcaa ataaataagt attttactgt 22500 tttcgtaaca gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc 22560 accatcgggc gcggatccgc caccggatcc gccaccatgc gtctgtgccg tgtgtggctg 22620 tccgtgtgcc tgtgcgctgt ggtgctggga cagtgccagc gtgaaaccgc tgagaagaac 22680 gactactacc gtgtgcccca ctactgggac gcttgctccc gtgctctgcc cgaccagacc 22740 cgttacaagt acgtcgagca gctggtggac ctgaccctga actaccacta cgacgcttcc 22800 cacggcctgg acaacttcga cgtgctgaag cgtatcaacg tgaccgaggt gtccctgctg 22860 atctccgact tccgtcgtca gaaccgtcgt ggtggcacca acaagcgtac caccttcaac 22920 gctgctggtt ccctggctcc ccacgctcgt tccttggagt tctccgtgcg tctgttcgcc 22980 aactaataaa agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta 23040 gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 23100 aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat 23160 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 23220 aaactcatca atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc 23280 ggctgctaac aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact 23340 atcataaccc ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca 23400 aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt 23460 ccggattatt cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt 23520 caaaggccta ccgtcgacgc caccatggaa tcccgtatct ggtgcctggt cgtgtgcgtg 23580 aacctgtgca tcgtgtgcct gggtgctgct gtgtcctcct cctccacccg tggcacctcc 23640 gctacccact cccaccactc ctcccacacc acctccgccg ctcactcccg ttccggttcc 23700 gtgtcccagc gtgtgacctc ctcccagacc gtgtcccacg gtgtcaacga gactatctac 23760 aacaccaccc tgaagtacgg cgacgtcgtg ggtgtcaaca ccaccaagta cccctaccgt 23820 gtgtgctcca tggctcaggg caccgacctg atccgtttcg agcgtaacat cgtgtgcacc 23880 tccatgaagc ccatcaacga ggacctggac gagggtatca tggtggtgta caagcgcaac 23940 atcgtggctc acaccttcaa ggtccgcgtg taccagaagg tgctgacctt ccgtcgttcc 24000 tacgcttaca tccacaccac ttacctgctg ggttccaaca ccgagtacgt ggcccctccc 24060 atgtgggaga tccaccacat caactcccac tcccagtgct actcctctta ctcccgtgtg 24120 atcgctggca ccgtgttcgt ggcttaccac cgtgactcct acgagaacaa gaccatgcag 24180 ctgatgcccg acgactactc caacacccac tccacccgtt acgtgaccgt gaaggaccag 24240 tggcactccc gtggttccac ctggctgtac cgtgaaacct gcaacctgaa ctgcatggtc 24300 accatcacca ccgctcgttc caagtaccct taccacttct tcgctacctc caccggcgac 24360 gtggtggaca tctccccctt ctacaacggt actaaccgta acgcttccta cttcggcgag 24420 aacgctgaca agttcttcat cttccccaac tacaccatcg tgtccgactt cggtcgtccc 24480 aactccgctc tggaaaccca ccgtctggtg gctttcttgg agcgtgctga ctccgtgatc 24540 tcctgggaca tccaggacga gaagaacgtg acctgccagc tgaccttctg ggaggcttcc 24600 gagcgtacca tccgttccga ggctgaggac tcctaccact tctccagcgc taagatgacc 24660 gctaccttcc tgtccaagaa acaagaggtc aacatgtccg actccgccct ggactgcgtg 24720 cgtgacgagg ctatcaacaa gctgcagcag atcttcaaca cctcctacaa ccagacctac 24780 gagaagtacg gaaacgtgtc cgtgttcgag actaccggtg gcctggtggt gttctggcag 24840 ggtatcaagc agaagtccct ggtcgagctg gaacgtctgg ctaaccgttc ctccctgaac 24900 ctgacccaca accgtaccaa gcgttccacc gacggcaaca acgctactca cctgtccaac 24960 atggaatccg tgcacaacct ggtgtacgct cagctgcagt tcacctacga caccctgcgc 25020 ggttacatca accgtgctct ggctcagatc gctgaggctt ggtgcgtgga ccagcgtcgt 25080 accctggaag tgttcaagga actgtccaag atcaacccct ccgctatcct gtccgccatc 25140 tacaacaagc ctatcgctgc tcgtttcatg ggcgacgtgc tgggcctggc ttcctgcgtg 25200 accatcaacc agacttccgt gaaggtgctg cgtgacatga acgtgaagga atcccccggt 25260 cgttgctact cccgtcccgt ggtcatcttc aacttcgcta actcctccta cgtgcagtac 25320 ggccagctgg gcgaggacaa cgagatcctg ctgggcaacc accgtaccga ggaatgccag 25380 ctgccctccc tgaagatctt catcgctggc aactccgctt acgaatacgt ggactacctg 25440 ttcaagcgca tgatcgacct gtcctccatc tctaccgtgg actccatgat cgctctggac 25500 atcgaccccc tggaaaacac cgacttccgt gtgctggaac tgtactccca gaaggaactg 25560 cgttccatca acgtgttcga cctggaagag atcatgcgcg agttcaactc ctacaagcag 25620 cgtgttaagt acgtcgagga caaggtggtg gaccccctgc ccccctacct gaagggactg 25680 gacgacctga tgtccggcct gggagctgcc ggcaaggctg tgggtgtcgc tatcggtgct 25740 gtgggtggtg ctgtggcttc cgtggtcgag ggtgtcgcca ccttcctgaa gaaccccttc 25800 ggtgctttca ccatcatcct ggtggctatc gctgtggtca tcatcatcta cctgatctac 25860 acccgtcagc gtcgtctgtg catgcagccc ctgcagaacc tgttccccta cctggtgtcc 25920 gctgacggta ctaccgtgac ctccggcaac accaaggaca cctccctgca ggctccccca 25980 tcctacgagg aatccgtcta caactccggt cgcaagggtc ccggtccccc ttcctccgac 26040 gcttctaccg ctgctccccc atacaccaac gagcaggctt accagatgct gctggctctc 26100 gtgcgtctgg acgctgagca gcgtgcacag cagaacggca ccgactccct ggacggccag 26160 accggaaccc aggacaaggg ccagaagccc aacctgctgg accgtctgcg tcaccgcaag 26220 aacggttacc gtcacctgaa ggactccgac gaggaagaga acgtctaagg cgcgccaagc 26280 ttgtcgagaa gtactagaga tcataatcag ccataccaca tttgtagagg ttttacttgc 26340 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 26400 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 26460 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 26520 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 26580 cccgaaagga agctgggaat attaatagat catggagata attaaaatga taaccatctc 26640 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 26700 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat gcgtcccggc 26760 ctgccctcct acctgatcgt gctggctgtg tgcctgctgt cccacctcct gtcctcccgt 26820 tacggtgctg aggctatctc cgagcccctg gacaaggctt tccacctcct gctgaacacc 26880 tacggtcgtc ctatccgttt cctgcgcgag aacaccaccc agtgcaccta caactcctcc 26940 ctgcgcaact ccaccgtcgt ccgcgagaac gctatctcct tcaacttctt ccagtcctac 27000 aaccagtact acgtgttcca catgccccgt tgcctgttcg ctggtcccct ggctgagcag 27060 ttcctgaacc aggtggacct gaccgagact ctcgagcgtt accagcagcg tctgaacact 27120 tacgctctgg tgtccaagga cctggcttcc taccgttcct tcagccagca gctgaaggct 27180 caggactccc tgggcgagca gcccaccact gtgcctcccc ctatcgacct gtccatcccc 27240 cacgtgtgga tgccccccca gaccactcct cacggctgga ccgagtccca caccacctcc 27300 ggactgcacc gtccccactt caaccagacc tgcatcctgt tcgacggtca cgacctgctg 27360 ttctccaccg tgaccccctg cctgcaccag ggcttctacc tcatcgacga gctgcgttac 27420 gtgaagatca ccctgaccga ggatttcttc gtggtcaccg tgtccatcga cgacgacacc 27480 cccatgctgc tgatcttcgg tcacctcccc cgtgtgctgt tcaaggctcc ctaccagcgt 27540 gacaacttca tcctgcgtca gaccgagaag cacgagctgc tggtgctggt caagaaggac 27600 cagctgaacc gtcactctta cctgaaggac cccgacttcc tggacgctgc tctggacttc 27660 aactacctgg acctgtccgc tctgctgagg aactccttcc accgttacgc tgtggacgtg 27720 ctgaagtccg gtcgttgcca gatgctggac cgtcgtaccg tcgagatggc tttcgcttac 27780 gccctggctc tgttcgctgc tgctcgtcaa gaagaggctg gcgctcaggt gtccgtgccc 27840 cgtgctctgg accgtcaggc tgctctgctg cagatccaag agttcatgat cacttgcctg 27900 tcccagaccc cccctcgtac caccctgctg ctgtacccca ccgctgtgga cctggctaag 27960 cgtgctctgt ggacccccaa ccagatcacc gacatcacct ccctcgtgcg tctggtgtac 28020 atcctgtcca agcagaacca gcagcacctg atcccccagt gggctctgcg tcagatcgct 28080 gacttcgctc tgaagctgca caagacccac ctggcttcat tcctcagcgc tttcgctcgc 28140 caagagctgt acctgatggg ttccctggtg cactccatgc tggtgcacac caccgagcgt 28200 cgcgagatct tcatcgtgga aaccggcctg tgctccctgg ccgagctgtc ccacttcacc 28260 cagctgctgg ctcaccccca ccacgagtac ctgtccgacc tgtacacccc ctgctcctct 28320 tccggtcgtc gtgaccactc cctggaacgt ctgacccgtc tgttccccga cgctaccgtg 28380 cctaccaccg tgcctgctgc tctgtccatc ctgtctacca tgcagccctc caccctggaa 28440 accttccccg acctgttctg cctgcctctg ggcgagtcct tctccgctct gaccgtgtcc 28500 gagcacgtgt cctacgtggt caccaaccag tacctgatca agggcatctc ctaccccgtg 28560 tccaccaccg tcgtgggcca gtccctgatc atcacccaga ccgactccca gaccaagtgc 28620 gagctgaccc gtaacatgca caccactcac tccatcaccg ctgctctgaa catctccctc 28680 gagaactgcg ctttctgcca gtccgctctg ttggagtacg acgacactca gggtgtcatc 28740 aacatcatgt acatgcacga ctccgacgac gtgctgttcg ctctggaccc ctacaacgag 28800 gtggtggtgt cctccccccg tacccactac ctgatgctgc tgaagaacgg caccgtgctg 28860 gaagtgaccg acgtggtggt ggacgctacc gaccgtctgc tgatgatgtc cgtgtacgct 28920 ctgtccgcta tcatcggcat ctacctgctg taccgtatgc tgaagacctg ctaaggcgcc 28980 aagctttgtc gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt 29040 acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat 29100 tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 29160 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 29220 caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta 29280 acaaagcccg aaaggaagct gagttggctg ctgccaccgc tgagcaataa ctatcataac 29340 ccctaggaga tccgaaccag ataagtgaaa tctagttcca aactattttg tcatttttaa 29400 ttttcgtatt agcttacgac gctacaccca gttcccatct attttgtcac tcttccctaa 29460 ataatcctta aaaactccat ttccacccct cccagttccc aactattttg tccgcccaca 29520 <210> 48 <211> 15042 <212> DNA <213> Artificial <220> <223> Synthetic sequence <400> 48 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttactgcagc caccaccaca gggagttcag ggtggacagg 2400 ttcacagcac gacggtgctc agggggggtc aggttgccgt aggtggagga ctgcaggctg 2460 aagttacgga tctcagacag gaacagcagg gagtccaggt agtcccacat ggggtcgatg 2520 aaggtgcgct ggaaacgggt ggatggggag gtgggggtgg tcttgttgtt gtcggaagca 2580 gtctcgttct cgacgggcat ggtgtcgttg tagtacaggg aggacatgtc cagggtgccg 2640 tagatggtgt agggagtctc gttacggatc agcacgtgag tgttcttcat gaactcggac 2700 acagcggtac ggttacggtt gggcttgcag aagggctcgt cacggtaacg cagggtggtg 2760 tacacccagg tagccaggtc cttcagctga gtggtcagga tagacttcat gaagttctcg 2820 tcgggacggt aaccgatggt agaggtgggg atacgggtgg gcacgatggg ggagtaggtc 2880 acgttggtgg aaacgttgaa gatggtggag gtgtaggagg agtagggggt agtagtgctg 2940 acgcgggact tcttggagat ggacttcacg ggagcctgct tgcgcttcag cttgcgcatg 3000 gtgttcttca gcttggtgga gttgatgtac ttgggcacac ggaagatgtt acgggacata 3060 gcgttgacca ggtagaagga acgggtgcag ttgcgctgag cgtaacgcag cagcagagca 3120 gccaggccca ggaagtagat agtctgggag tccacgttga ccttggaggg gcccacgtac 3180 agcttggtgt tccaacgggg cacgttgaag aacatggggt tgaaggtggt gaagttgccg 3240 cagttttcct cgccggtgtt gttacgacgg gacacgttca gcatctcgga caggcaggtc 3300 atggagggga tggtgccgca agagggggga cggaaggtga tcttctggcc ggtgtggttg 3360 tactcggagt acacgtactt agcgggcttg cgcagctggg tggtgtggaa gtcgaaccac 3420 aggtgggtga tggagtggtt acggatggga ccagccagga tggagttggg ggggaactgc 3480 ttcatctcga cggtgatgtt gtacagcttc tgctggctgg ggaaggtgaa gaacttgtag 3540 tagtcgccgg tcttggaagc cagctcttgc aggatacgca gcttcagctg gcgttcctct 3600 tccttagcct tctgggactt cacacggaaa cgagccacag cgatcttgca gttgatgaag 3660 ctgaacagca ggaaggtcag ggacatcagg aagaacaggt tgaacacgcc acgcatctcg 3720 cccttgcgac ccatggtggc ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 3780 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 3840 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 3900 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 3960 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 4020 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat ggaaaactgg 4080 tccgctctgg aactgctgcc caaggtcgga atccctaccg acttcctgac ccacgtcaag 4140 acctccgctg gcgaggaaat gttcgaggct ctgaggatct actacggcga cgaccccgag 4200 cgttacaaca tccacttcga ggctatcttc ggcaccttct gcaaccgtct ggaatgggtg 4260 tacttcctga cttccggcct ggctgctgct gctcacgcta tcaagttcca cgacctgaac 4320 aagctgacca ccggcaagat gctgttccac gtgcaagtgc cccgtgtggc ttccggtgct 4380 ggcctgccta cctcccgtca gaccaccatc atggtcacca agtactccga gaagtccccc 4440 atcaccatcc ctttcgagct gtccgctgct tgcctgactt acctgcgtga aaccttcgag 4500 ggcaccatcc tggacaagat cctgaacgtc gaggctatgc acaccgtgct gcgtgctctg 4560 aagaacaccg ctgacgctat ggaacgtggc ctgatccaca gcttcctcca gaccctgctg 4620 aggaaggctc ccccctactt cgtggtgcag accctggtcg agaacgctac cctggctcgt 4680 caggctctga accgtatcca gcgctccaac atcctgcagt ccttcaaggc taagatgctg 4740 gctaccctgt tcctgctgaa ccgtacccgt gaccgtgact acgtgctgaa gttcctgacc 4800 cgtctggctg aggctgctac cgactccatc ctcgacaacc ctactaccta caccacctcc 4860 tccggtgcta agatctccgg tgtcatggtg tccaccgcta acgtgatgca gatcatcatg 4920 tccctgctgt cctcccacat cactaaggaa accgtgtccg ctcccgctac ctacggcaac 4980 ttcgtgctgt cccccgagaa cgctgtgacc gctatctcct accactctat cctggctgac 5040 ttcaactcct acaaggctca cctgacctcc ggccagcccc acctccccaa cgactccctg 5100 agccaggctg gtgctcactc cctgaccccc ctgtccatgg acgtgatccg tctgggcgaa 5160 aagaccgtga tcatggaaaa cctgcgtcgc gtgtacaaga acaccgacac caaggacccc 5220 ctggaacgta acgtggacct gaccttcttc ttccccgtgg gcctgtacct gcccgaggac 5280 cgtggttaca ccaccgtcga gtccaaggtc aagctgaacg acaccgtgcg taacgctctg 5340 cccaccaccg cttacctgct gaacagggac cgtgctgtgc aaaagatcga cttcgtggac 5400 gctctcaaga ccctgtgcca ccccgtgctg cacgagcctg ctccatgcct gcaggctttc 5460 accgagcgtg gtcccccatc cgagcccgct atgcagcgtc tgctggaatg ccgtttccag 5520 caagagccca tgggtggtgc tgctcgtcgt atcccccact tctaccgtgt gcgccgcgag 5580 gtgccccgta ccgtgaacga gatgaagcag gacttcgtgg tcaccgactt ctacaaggtt 5640 ggaaacatca ccctgtacac cgagctgcac cctttcttcg acttcaccca ctgccaagag 5700 aactccgaga ctgtggctct gtgcaccccc cgtatcgtga tcggcaacct gcccgacggc 5760 ctggctcccg gtcccttcca cgagctgagg acctgggaga tcatggaaca catgcgcctg 5820 cgtcccccac ccgactacga ggaaaccctg cgtctgttca agaccaccgt gacctccccc 5880 aactaccccg agctgtgcta cctggtggac gtgctggtgc acggcaacgc tgacgctttc 5940 ctgctgatcc gcgctttcat cgctcgttgc atcgtgaaca tgttccacac ccgtcagctg 6000 ctggtgttcg ctcactccta cgctctggtc accctgatcg ctgagcacct ggctgacggt 6060 gctctgcccc cccagctcct gttccactac cgtaacctgg tggctgtgct gcgcctggtc 6120 acccgtatct ccgctctgcc cggcctgaac aacggccagc tggctgagga acccctgtcc 6180 gcttacgtga acgctctgca cgaccacagg ctgtggcccc ccttcgtgac ccacctccct 6240 cgtaacatgg aaggtgtcca ggtggtggct gatcgtcagc ccctgaaccc cgctaacatc 6300 gaggctcgtc accacggtgt ctccgacgtg ccccgtctgg gtgctatgga cgctgacgag 6360 cccctgttcg tggacgacta ccgtgctacc gacgacgagt ggaccctgca aaaggtgttc 6420 tacctgtgcc tgatccccgc tatgaccaac aaccgtgctt gcggcctggg cctgaacctc 6480 aagactctgc tggtggacct gttctaccgt cccgccttcc tgctcatgcc cgctgctacc 6540 gctgtgtcca cctccggcac cacctccaag gaatccacct ctggtgtcac ccccgaggac 6600 tccgtggctg ctcagcgtca ggctgtgggc gagatgctga ccgagctggt cgaggacgtg 6660 gccaccgacg ctcacacccc tctgctgcag gcttgccgcg agctgttcct ggctgtgcag 6720 ttcgtgggcg agcacgtgaa ggtgctggaa gtgcgtgctc ccctggacca cgctcagagg 6780 cagggactgc ccgacttcat ctcccgtcag catgtgctgt acaacggttg ctgcgtcgtg 6840 accgctccta agaccctgat cgagtactcc ctgcccgtgc ccttccaccg tttctactcc 6900 aaccccacca tctgcgctgc tctgtccgac gacatcaagc gttacgtgac cgagttcccc 6960 cactaccata gacacgatgg tggtttcccc ctgcccaccg ctttcgctca cgagtaccac 7020 aactggctgc gtagcccctt ctcccgttac tccgctacct gccccaacgt gctgcactcc 7080 gtgatgaccc tggctgctat gctgtacaag atctcccccg tgtccctggt gctgcagacc 7140 aaggctcaca tccaccccgg tttcgctctg accgctgtgc gtaccgacac cttcgaggtg 7200 gacatgctgc tgtactccgg caagtcctgc acctccgtca tcatcaacaa ccccatcgtg 7260 accaaggaag agagggacat ctccaccacc taccacgtga cccagaacat caacaccgtg 7320 gacatgggcc tgggttacac ctccaacact tgcgtggcct acgtgaaccg cgtccgcacc 7380 gacatgggtg tccgtgtgca ggacctgttc cgtgtgttcc ccatgaacgt gtaccgccac 7440 gatgaggtgg accgttggat caggcacgct gctggcgtcg agcgtcccca gctgctggac 7500 accgagacta tctccatgct gaccttcggt tccatgtccg agcgcaacgc tgctgctacc 7560 gtgcacggcc agaaggctgt ctgcgagctg atcctgaccc ctgtgactat ggacgtgaac 7620 tacttcaaga tcaccaacaa ccctcgtggt cgtgcttcct gcatgctggg cgtggacccc 7680 tacgacaccg aggctgccac caaggctatc tacgaccacc gcgaggctga cgctcagacc 7740 ttcgctgcta cccacaaccc atgggcttcc caggctggtt gcctgtccga cgtcctgtac 7800 aacacccgtc accgcgagcg tctgggctac aactccaagt tctactcccc ctgcgctcag 7860 tacttcaaca ccgaggaaat catcgctgcc aacaagaccc tcttcaagac catcgacgag 7920 tacctgctgc gcgctaagga ctgcatccgt ggcgacaccg acactcagta cgtgtgcgtc 7980 gagggaaccg agcagctgat cgagaaccct tgccgtctga cccaagaggc tctgcccatc 8040 ctgtccacca ccaccctggc tctgatggaa actaagctga agggtggcgc tggtgctttc 8100 gctacctccg agactcactt cggcaactac gtcgtgggag agatcatccc cctgcagcag 8160 tccatgctgt tcaacagcta agagctcaag cttgtcgaga agtactagag gatcataatc 8220 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 8280 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 8340 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 8400 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 8460 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgt 8520 ggctagcttt gtttaacttt aagaaggaga tacatctaga ccggaatatt aatagatcat 8580 ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac 8640 agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg 8700 cgcggatccc ggtccgaagc gcgcggaatt caaaggccta cgtcgacgcc accatggaat 8760 cccgtggtcg tcgttgcccc gagatgatct ccgtgctggg tcccatctcc ggtcacgtcc 8820 tgaaggctgt gttctcccgt ggcgacaccc ccgtgctgcc ccacgaaact cgtctgctgc 8880 agaccggtat ccacgtgcgt gtgtcccagc cctccctgat cctggtgtcc cagtacaccc 8940 ccgactccac cccttgccac cgcggagaca accagctgca ggtccagcac acctacttca 9000 ccggttccga ggtcgagaac gtgtccgtga acgtgcacaa ccccaccggt cgttccatct 9060 gcccctccca agagcccatg tccatctacg tgtacgctct gcccctgaag atgctgaaca 9120 tcccctccat caacgtgcac cactacccct ccgctgctga gcgcaagcac cgtcacctcc 9180 ccgtggctga cgctgtgatc cacgcttccg gcaagcagat gtggcaggct cgtctgaccg 9240 tgtccggcct ggcttggacc cgtcagcaga accagtggaa ggaacccgac gtgtactaca 9300 cctccgcttt cgtgttcccc accaaggacg tggccctgcg tcacgtcgtg tgcgctcacg 9360 aactcgtgtg ctccatggaa aacacccgtg ctaccaagat gcaagtgatc ggcgaccagt 9420 acgtgaaggt gtacctggaa tccttctgcg aggacgtgcc ctccggcaag ctgttcatgc 9480 acgtgaccct gggttccgac gtggaagagg acctgaccat gacccgtaac ccccagccct 9540 tcatgcgtcc ccacgagcgt aacggtttca ccgtgctgtg ccccaagaac atgatcatca 9600 agcccggcaa gatctcccac atcatgctgg acgtggcctt cacctcccac gagcacttcg 9660 gcctgctgtg ccctaagtcc atccccggcc tgtccatctc cggcaacctg ctgatgaacg 9720 gccagcagat cttcctggaa gtgcaggcta tccgtgaaac cgtcgagctg cgtcagtacg 9780 accctgtggc tgctctgttc ttcttcgaca tcgacctgct gctgcagcgt ggtccccagt 9840 actccgagca ccccaccttc accagccagt accgtatcca gggcaagctg gaataccgtc 9900 acacctggga ccgtcacgac gagggtgctg ctcagggcga cgacgacgtg tggacctccg 9960 gttccgactc cgacgaggaa ctggtcacca ccgagcgcaa gaccccccgt gtgaccggtg 10020 gtggtgctat ggctggtgct tccacctccg ctggtcgcaa gcgcaagtcc gcttcctccg 10080 ctaccgcttg caccgctggt gtcatgaccc gtggtcgcct gaaggctgag tccaccgtgg 10140 ctcccgaaga ggacactgac gaggactccg acaacgagat ccacaacccc gctgtgttca 10200 cctggccccc ctggcaggct ggtatcctgg ctcgtaacct ggtgcccatg gtggctaccg 10260 tgcagggcca gaacctgaag taccaagagt tcttctggga cgccaacgac atctaccgta 10320 tcttcgctga gctggaaggc gtgtggcagc ccgctgctca gcccaagcgt cgtcgtcacc 10380 gtcaggacgc tctgcctggt ccctgtatcg cttccacccc caagaagcac cgcggctaaa 10440 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 10500 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 10560 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 10620 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 10680 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 10740 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccg 10800 gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat 10860 tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat 10920 accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcgc caccatgacc 10980 atggacgagc agcagcccca ggctgtgacc cccgtgtacg tgggcggttt cctggctcgt 11040 tacgaccagt cccccgacga ggctgagctg ctgctgccac gtgacgtggt cgaacactgg 11100 ctgcacgctc agggccaggg acagccttcc ctgtccgtgg ctctgcccct gaacatcaac 11160 cacgacgaca ccgctgtcgt gggtcacgtg gccgctatgc agtccgtgcg tgacggcctg 11220 ttctgcctgg gttgcgtgac ctccccccgt ttcctggaaa tcgtgcgtcg tgcttccgag 11280 aagtccgagc tggtgtcccg tggtcccgtg tccccactgc agcccgacaa ggtggtcgag 11340 ttcctgtccg gttcctacgc tggcctgtcc ctgtcatccc gtcgttgcga cgacgtcgag 11400 gctgctacct ccctgagcgg ctccgagact acccccttca agcacgtggc cctgtgctcc 11460 gtgggtcgta ggcgtggaac cctggctgtg tacggtcgtg accccgagtg ggtcacccag 11520 cgtttccccg acctgaccgc tgctgaccgt gacggactgc gtgctcagtg gcagcgttgc 11580 ggttccaccg ctgtggacgc ttccggcgac cccttccgtt ccgactccta cggcctgctg 11640 ggcaactccg tggacgctct gtacatccgc gagcgtctgc ccaagctgcg ttacgacaag 11700 cagctcgtgg gtgtcaccga gcgcgagtcc tacgtgaagg cttccgtgtc ccccgaggct 11760 gcttgcgaca tcaaggctgc ttccgctgag cgttctggcg acagccgctc ccaggctgct 11820 actcctgctg ctggtgctcg tgtgccctcc agctccccat ccccacctgt cgagcctccc 11880 tcccccgtgc aacctcctgc tctgcctgct tccccctccg tgctgcctgc tgagtccagc 11940 ccctccctgt caccctctga gcctgctgag gctgcctcca tgtcccaccc tctgagcgct 12000 gctgtgactg ctgctaccgc tccccctggt gctactgtgg ctggtgcttc ccccgctgtg 12060 ccttccctgg cttggcctca cgacggtgtc tacctgccca aggacgcttt cttctccctg 12120 ctgggcgctt cccgttccgc tgctcccgtg atgtaccccg gtgctgtggc tgctcccccc 12180 agcgcttcac ctgctcctct gcccctgccc tcctaccccg cttcctacgg tgctcccgtc 12240 gtgggttacg accagctggc tgctcgtcac ttcgctgact acgtggaccc ccactacccc 12300 ggctggggtc gtcgttacga gcccgctcct tccctgcacc catcctaccc tgtgccccct 12360 cctccatcac ccgcttacta ccgtcgtcgt gactcccccg gtggcatgga cgagcctcca 12420 tctggatggg agcgttacga cggttcccac cgtggccagt cccaaaagca gcaccgtcac 12480 ggtggttccg gtggtcacaa caagcgtcgc aaggaagccg ctgctgcatc ctccagctcc 12540 gacgaggacc tgagcttccc cggcgaggct gaacacggtc gtgctcgcaa gcgtctgaag 12600 tcccacgtga actccgacgg aggtagcgga ggccacgctg gttccaacca gcagcagcaa 12660 cagcgctacg acgagctgcg tgacgctatc cacgagctga agcgtgacct gttcgctgct 12720 cgccagtcct ccaccctgct gtctgctgct ctgccagctg ccgcttcttc ctcccctacc 12780 accaccaccg tgtgcacccc tactggcgag ctgacctctg gtggtggcga gactcccacc 12840 gctctgctgt ccggtggtgc taaggtggcc gagcgtgctc aggctggtgt cgtgaacgct 12900 tcctgccgtc tggctaccgc ttccggttcc gaggctgcca ccgctggtcc ctctaccgct 12960 ggttcctcat cctgcccagc ttccgtggtg ctggctgccg ctgctgctca agccgccgct 13020 gcttcacagt cccccccaaa ggatatggtg gacctgaacc gtcgtatctt cgtggctgct 13080 ctgaacaagc tcgagtaata aaagcttgtc gagaagtact agaggatcat aatcagccat 13140 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 13200 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 13260 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 13320 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 13380 cctagaagat ccggctgcta acaaagcccg aaaggaagct gggaatatta atagatcatg 13440 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 13500 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 13560 gcggatccgc caccatggct gctatggaag ctaacatctt ctgcaccttc gaccacaagc 13620 tgtctatcgc tgacgtgggc aagctgacca agctggtggc tgctgtggtg cccatccccc 13680 agcgtctgca cctgatcaag cactaccagc tgggcctgca ccagttcgtg gaccacaccc 13740 gtggttacgt gcgtctgcgt ggcctgctgc gtaacatgac cctgaccctg atgcgtcgtg 13800 tcgagggcaa ccagatcctg ctgcacgtgc ccacccacgg cctgctgtac accgtgctga 13860 acaccggtcc cgtgacctgg gagaagggcg acgctctgtg cgtgctgccc cccctgttcc 13920 acggtcccct ggctcgtgaa aacctgttga ccctgggcca gtgggagctg gtgctgccct 13980 ggatcgtgcc catgcccctg gctctggaaa tcaaccagcg cctgctgatc atgggcctgt 14040 tctccctgga ccgttcctac gaagaagtga aggctgctgt ccagcagctg cagaccatca 14100 ccttccgtga cgctaccttc accatccccg accccgtgat cgaccagcac ctcctgatcg 14160 acatgaagac cgcttgcctg tccatgtcca tggtggctaa cctggcttcc gagctgacca 14220 tgacctacgt ccgcaagctg gctttggagg actcttccat gctgctggtc aagtgccaag 14280 agctgctgat gcgtctggac cgcgagcgtt ccgtgggcga gcctcgtact cccgctcgtc 14340 ctcagcacgt gtcccccgac gacgagatcg ctcgtctgtc cgctctgttc gtgatgctgc 14400 gtcagctgga cgacctgatc cgcgagcagg tcgtgttcac cgtgtgcgac gtgagcccag 14460 acaacaagtc cgctacctgc atcttcaagg gctaaggcgc gccaagcttg tcgagaagta 14520 ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 14580 cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 14640 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 14700 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 14760 ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag 14820 ctgagttggc tgctgccacc gctgagcaat aactatcata acccctagga gatccgaacc 14880 agataagtga aatctagttc caaactattt tgtcattttt aattttcgta ttagcttacg 14940 acgctacacc cagttcccat ctattttgtc actcttccct aaataatcct taaaaactcc 15000 atttccaccc ctcccagttc ccaactattt tgtccgccca ca 15042 <210> 49 <211> 27364 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 49 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttac tgcagccacc accacaggga gttcagggtg gacaggttca 2400 cagcacgacg gtgctcaggg ggggtcaggt tgccgtaggt ggaggactgc aggctgaagt 2460 tacggatctc agacaggaac agcagggagt ccaggtagtc ccacatgggg tcgatgaagg 2520 tgcgctggaa acgggtggat ggggaggtgg gggtggtctt gttgttgtcg gaagcagtct 2580 cgttctcgac gggcatggtg tcgttgtagt acagggagga catgtccagg gtgccgtaga 2640 tggtgtaggg agtctcgtta cggatcagca cgtgagtgtt cttcatgaac tcggacacag 2700 cggtacggtt acggttgggc ttgcagaagg gctcgtcacg gtaacgcagg gtggtgtaca 2760 cccaggtagc caggtccttc agctgagtgg tcaggataga cttcatgaag ttctcgtcgg 2820 gacggtaacc gatggtagag gtggggatac gggtgggcac gatgggggag taggtcacgt 2880 tggtggaaac gttgaagatg gtggaggtgt aggaggagta gggggtagta gtgctgacgc 2940 gggacttctt ggagatggac ttcacgggag cctgcttgcg cttcagcttg cgcatggtgt 3000 tcttcagctt ggtggagttg atgtacttgg gcacacggaa gatgttacgg gacatagcgt 3060 tgaccaggta gaaggaacgg gtgcagttgc gctgagcgta acgcagcagc agagcagcca 3120 ggcccaggaa gtagatagtc tgggagtcca cgttgacctt ggaggggccc acgtacagct 3180 tggtgttcca acggggcacg ttgaagaaca tggggttgaa ggtggtgaag ttgccgcagt 3240 tttcctcgcc ggtgttgtta cgacgggaca cgttcagcat ctcggacagg caggtcatgg 3300 aggggatggt gccgcaagag gggggacgga aggtgatctt ctggccggtg tggttgtact 3360 cggagtacac gtacttagcg ggcttgcgca gctgggtggt gtggaagtcg aaccacaggt 3420 gggtgatgga gtggttacgg atgggaccag ccaggatgga gttggggggg aactgcttca 3480 tctcgacggt gatgttgtac agcttctgct ggctggggaa ggtgaagaac ttgtagtagt 3540 cgccggtctt ggaagccagc tcttgcagga tacgcagctt cagctggcgt tcctcttcct 3600 tagccttctg ggacttcaca cggaaacgag ccacagcgat cttgcagttg atgaagctga 3660 acagcaggaa ggtcagggac atcaggaaga acaggttgaa cacgccacgc atctcgccct 3720 tgcgacccat ggtggcctcg agatcccggg tgatcaagtc ttcgtcgagt gattgtaaat 3780 aaaatgtaat ttacagtata gtattttaat taatatacaa atgatttgat aataattctt 3840 atttaactat aatatattgt gttgggttga attaaaggtc cgtatactag tatcgattcg 3900 cgacctactc cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa 3960 ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc 4020 cggattattc ataccgtccc accatcgggc gcggatccgc caccatggaa aactggtccg 4080 ctctggaact gctgcccaag gtcggaatcc ctaccgactt cctgacccac gtcaagacct 4140 ccgctggcga ggaaatgttc gaggctctga ggatctacta cggcgacgac cccgagcgtt 4200 acaacatcca cttcgaggct atcttcggca ccttctgcaa ccgtctggaa tgggtgtact 4260 tcctgacttc cggcctggct gctgctgctc acgctatcaa gttccacgac ctgaacaagc 4320 tgaccaccgg caagatgctg ttccacgtgc aagtgccccg tgtggcttcc ggtgctggcc 4380 tgcctacctc ccgtcagacc accatcatgg tcaccaagta ctccgagaag tcccccatca 4440 ccatcccttt cgagctgtcc gctgcttgcc tgacttacct gcgtgaaacc ttcgagggca 4500 ccatcctgga caagatcctg aacgtcgagg ctatgcacac cgtgctgcgt gctctgaaga 4560 acaccgctga cgctatggaa cgtggcctga tccacagctt cctccagacc ctgctgagga 4620 aggctccccc ctacttcgtg gtgcagaccc tggtcgagaa cgctaccctg gctcgtcagg 4680 ctctgaaccg tatccagcgc tccaacatcc tgcagtcctt caaggctaag atgctggcta 4740 ccctgttcct gctgaaccgt acccgtgacc gtgactacgt gctgaagttc ctgacccgtc 4800 tggctgaggc tgctaccgac tccatcctcg acaaccctac tacctacacc acctcctccg 4860 gtgctaagat ctccggtgtc atggtgtcca ccgctaacgt gatgcagatc atcatgtccc 4920 tgctgtcctc ccacatcact aaggaaaccg tgtccgctcc cgctacctac ggcaacttcg 4980 tgctgtcccc cgagaacgct gtgaccgcta tctcctacca ctctatcctg gctgacttca 5040 actcctacaa ggctcacctg acctccggcc agccccacct ccccaacgac tccctgagcc 5100 aggctggtgc tcactccctg acccccctgt ccatggacgt gatccgtctg ggcgaaaaga 5160 ccgtgatcat ggaaaacctg cgtcgcgtgt acaagaacac cgacaccaag gaccccctgg 5220 aacgtaacgt ggacctgacc ttcttcttcc ccgtgggcct gtacctgccc gaggaccgtg 5280 gttacaccac cgtcgagtcc aaggtcaagc tgaacgacac cgtgcgtaac gctctgccca 5340 ccaccgctta cctgctgaac agggaccgtg ctgtgcaaaa gatcgacttc gtggacgctc 5400 tcaagaccct gtgccacccc gtgctgcacg agcctgctcc atgcctgcag gctttcaccg 5460 agcgtggtcc cccatccgag cccgctatgc agcgtctgct ggaatgccgt ttccagcaag 5520 agcccatggg tggtgctgct cgtcgtatcc cccacttcta ccgtgtgcgc cgcgaggtgc 5580 cccgtaccgt gaacgagatg aagcaggact tcgtggtcac cgacttctac aaggttggaa 5640 acatcaccct gtacaccgag ctgcaccctt tcttcgactt cacccactgc caagagaact 5700 ccgagactgt ggctctgtgc accccccgta tcgtgatcgg caacctgccc gacggcctgg 5760 ctcccggtcc cttccacgag ctgaggacct gggagatcat ggaacacatg cgcctgcgtc 5820 ccccacccga ctacgaggaa accctgcgtc tgttcaagac caccgtgacc tcccccaact 5880 accccgagct gtgctacctg gtggacgtgc tggtgcacgg caacgctgac gctttcctgc 5940 tgatccgcgc tttcatcgct cgttgcatcg tgaacatgtt ccacacccgt cagctgctgg 6000 tgttcgctca ctcctacgct ctggtcaccc tgatcgctga gcacctggct gacggtgctc 6060 tgccccccca gctcctgttc cactaccgta acctggtggc tgtgctgcgc ctggtcaccc 6120 gtatctccgc tctgcccggc ctgaacaacg gccagctggc tgaggaaccc ctgtccgctt 6180 acgtgaacgc tctgcacgac cacaggctgt ggcccccctt cgtgacccac ctccctcgta 6240 acatggaagg tgtccaggtg gtggctgatc gtcagcccct gaaccccgct aacatcgagg 6300 ctcgtcacca cggtgtctcc gacgtgcccc gtctgggtgc tatggacgct gacgagcccc 6360 tgttcgtgga cgactaccgt gctaccgacg acgagtggac cctgcaaaag gtgttctacc 6420 tgtgcctgat ccccgctatg accaacaacc gtgcttgcgg cctgggcctg aacctcaaga 6480 ctctgctggt ggacctgttc taccgtcccg ccttcctgct catgcccgct gctaccgctg 6540 tgtccacctc cggcaccacc tccaaggaat ccacctctgg tgtcaccccc gaggactccg 6600 tggctgctca gcgtcaggct gtgggcgaga tgctgaccga gctggtcgag gacgtggcca 6660 ccgacgctca cacccctctg ctgcaggctt gccgcgagct gttcctggct gtgcagttcg 6720 tgggcgagca cgtgaaggtg ctggaagtgc gtgctcccct ggaccacgct cagaggcagg 6780 gactgcccga cttcatctcc cgtcagcatg tgctgtacaa cggttgctgc gtcgtgaccg 6840 ctcctaagac cctgatcgag tactccctgc ccgtgccctt ccaccgtttc tactccaacc 6900 ccaccatctg cgctgctctg tccgacgaca tcaagcgtta cgtgaccgag ttcccccact 6960 accatagaca cgatggtggt ttccccctgc ccaccgcttt cgctcacgag taccacaact 7020 ggctgcgtag ccccttctcc cgttactccg ctacctgccc caacgtgctg cactccgtga 7080 tgaccctggc tgctatgctg tacaagatct cccccgtgtc cctggtgctg cagaccaagg 7140 ctcacatcca ccccggtttc gctctgaccg ctgtgcgtac cgacaccttc gaggtggaca 7200 tgctgctgta ctccggcaag tcctgcacct ccgtcatcat caacaacccc atcgtgacca 7260 aggaagagag ggacatctcc accacctacc acgtgaccca gaacatcaac accgtggaca 7320 tgggcctggg ttacacctcc aacacttgcg tggcctacgt gaaccgcgtc cgcaccgaca 7380 tgggtgtccg tgtgcaggac ctgttccgtg tgttccccat gaacgtgtac cgccacgatg 7440 aggtggaccg ttggatcagg cacgctgctg gcgtcgagcg tccccagctg ctggacaccg 7500 agactatctc catgctgacc ttcggttcca tgtccgagcg caacgctgct gctaccgtgc 7560 acggccagaa ggctgtctgc gagctgatcc tgacccctgt gactatggac gtgaactact 7620 tcaagatcac caacaaccct cgtggtcgtg cttcctgcat gctgggcgtg gacccctacg 7680 acaccgaggc tgccaccaag gctatctacg accaccgcga ggctgacgct cagaccttcg 7740 ctgctaccca caacccatgg gcttcccagg ctggttgcct gtccgacgtc ctgtacaaca 7800 cccgtcaccg cgagcgtctg ggctacaact ccaagttcta ctccccctgc gctcagtact 7860 tcaacaccga ggaaatcatc gctgccaaca agaccctctt caagaccatc gacgagtacc 7920 tgctgcgcgc taaggactgc atccgtggcg acaccgacac tcagtacgtg tgcgtcgagg 7980 gaaccgagca gctgatcgag aacccttgcc gtctgaccca agaggctctg cccatcctgt 8040 ccaccaccac cctggctctg atggaaacta agctgaaggg tggcgctggt gctttcgcta 8100 cctccgagac tcacttcggc aactacgtcg tgggagagat catccccctg cagcagtcca 8160 tgctgttcaa cagctaagag ctcaagcttg tcgagaagta ctagaggatc ataatcagcc 8220 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 8280 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 8340 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 8400 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 8460 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgtggct 8520 agctttgttt aactttaaga aggagataca tctagaccgg aatattaata gatcatggag 8580 ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt 8640 ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg 8700 gatcccggtc cgaagcgcgc ggaattcaaa ggcctacgtc gacgccacca tggaatcccg 8760 tggtcgtcgt tgccccgaga tgatctccgt gctgggtccc atctccggtc acgtcctgaa 8820 ggctgtgttc tcccgtggcg acacccccgt gctgccccac gaaactcgtc tgctgcagac 8880 cggtatccac gtgcgtgtgt cccagccctc cctgatcctg gtgtcccagt acacccccga 8940 ctccacccct tgccaccgcg gagacaacca gctgcaggtc cagcacacct acttcaccgg 9000 ttccgaggtc gagaacgtgt ccgtgaacgt gcacaacccc accggtcgtt ccatctgccc 9060 ctcccaagag cccatgtcca tctacgtgta cgctctgccc ctgaagatgc tgaacatccc 9120 ctccatcaac gtgcaccact acccctccgc tgctgagcgc aagcaccgtc acctccccgt 9180 ggctgacgct gtgatccacg cttccggcaa gcagatgtgg caggctcgtc tgaccgtgtc 9240 cggcctggct tggacccgtc agcagaacca gtggaaggaa cccgacgtgt actacacctc 9300 cgctttcgtg ttccccacca aggacgtggc cctgcgtcac gtcgtgtgcg ctcacgaact 9360 cgtgtgctcc atggaaaaca cccgtgctac caagatgcaa gtgatcggcg accagtacgt 9420 gaaggtgtac ctggaatcct tctgcgagga cgtgccctcc ggcaagctgt tcatgcacgt 9480 gaccctgggt tccgacgtgg aagaggacct gaccatgacc cgtaaccccc agcccttcat 9540 gcgtccccac gagcgtaacg gtttcaccgt gctgtgcccc aagaacatga tcatcaagcc 9600 cggcaagatc tcccacatca tgctggacgt ggccttcacc tcccacgagc acttcggcct 9660 gctgtgccct aagtccatcc ccggcctgtc catctccggc aacctgctga tgaacggcca 9720 gcagatcttc ctggaagtgc aggctatccg tgaaaccgtc gagctgcgtc agtacgaccc 9780 tgtggctgct ctgttcttct tcgacatcga cctgctgctg cagcgtggtc cccagtactc 9840 cgagcacccc accttcacca gccagtaccg tatccagggc aagctggaat accgtcacac 9900 ctgggaccgt cacgacgagg gtgctgctca gggcgacgac gacgtgtgga cctccggttc 9960 cgactccgac gaggaactgg tcaccaccga gcgcaagacc ccccgtgtga ccggtggtgg 10020 tgctatggct ggtgcttcca cctccgctgg tcgcaagcgc aagtccgctt cctccgctac 10080 cgcttgcacc gctggtgtca tgacccgtgg tcgcctgaag gctgagtcca ccgtggctcc 10140 cgaagaggac actgacgagg actccgacaa cgagatccac aaccccgctg tgttcacctg 10200 gcccccctgg caggctggta tcctggctcg taacctggtg cccatggtgg ctaccgtgca 10260 gggccagaac ctgaagtacc aagagttctt ctgggacgcc aacgacatct accgtatctt 10320 cgctgagctg gaaggcgtgt ggcagcccgc tgctcagccc aagcgtcgtc gtcaccgtca 10380 ggacgctctg cctggtccct gtatcgcttc cacccccaag aagcaccgcg gctaaaagct 10440 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 10500 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 10560 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 10620 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 10680 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 10740 cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca taaccggaat 10800 attaatagat catggagata attaaaatga taaccatctc gcaaataaat aagtatttta 10860 ctgttttcgt aacagttttg taataaaaaa acctataaat attccggatt attcataccg 10920 tcccaccatc gggcgcggat cccggtccga agcgcgcgga attcgccacc atgaccatgg 10980 acgagcagca gccccaggct gtgacccccg tgtacgtggg cggtttcctg gctcgttacg 11040 accagtcccc cgacgaggct gagctgctgc tgccacgtga cgtggtcgaa cactggctgc 11100 acgctcaggg ccagggacag ccttccctgt ccgtggctct gcccctgaac atcaaccacg 11160 acgacaccgc tgtcgtgggt cacgtggccg ctatgcagtc cgtgcgtgac ggcctgttct 11220 gcctgggttg cgtgacctcc ccccgtttcc tggaaatcgt gcgtcgtgct tccgagaagt 11280 ccgagctggt gtcccgtggt cccgtgtccc cactgcagcc cgacaaggtg gtcgagttcc 11340 tgtccggttc ctacgctggc ctgtccctgt catcccgtcg ttgcgacgac gtcgaggctg 11400 ctacctccct gagcggctcc gagactaccc ccttcaagca cgtggccctg tgctccgtgg 11460 gtcgtaggcg tggaaccctg gctgtgtacg gtcgtgaccc cgagtgggtc acccagcgtt 11520 tccccgacct gaccgctgct gaccgtgacg gactgcgtgc tcagtggcag cgttgcggtt 11580 ccaccgctgt ggacgcttcc ggcgacccct tccgttccga ctcctacggc ctgctgggca 11640 actccgtgga cgctctgtac atccgcgagc gtctgcccaa gctgcgttac gacaagcagc 11700 tcgtgggtgt caccgagcgc gagtcctacg tgaaggcttc cgtgtccccc gaggctgctt 11760 gcgacatcaa ggctgcttcc gctgagcgtt ctggcgacag ccgctcccag gctgctactc 11820 ctgctgctgg tgctcgtgtg ccctccagct ccccatcccc acctgtcgag cctccctccc 11880 ccgtgcaacc tcctgctctg cctgcttccc cctccgtgct gcctgctgag tccagcccct 11940 ccctgtcacc ctctgagcct gctgaggctg cctccatgtc ccaccctctg agcgctgctg 12000 tgactgctgc taccgctccc cctggtgcta ctgtggctgg tgcttccccc gctgtgcctt 12060 ccctggcttg gcctcacgac ggtgtctacc tgcccaagga cgctttcttc tccctgctgg 12120 gcgcttcccg ttccgctgct cccgtgatgt accccggtgc tgtggctgct ccccccagcg 12180 cttcacctgc tcctctgccc ctgccctcct accccgcttc ctacggtgct cccgtcgtgg 12240 gttacgacca gctggctgct cgtcacttcg ctgactacgt ggacccccac taccccggct 12300 ggggtcgtcg ttacgagccc gctccttccc tgcacccatc ctaccctgtg ccccctcctc 12360 catcacccgc ttactaccgt cgtcgtgact cccccggtgg catggacgag cctccatctg 12420 gatgggagcg ttacgacggt tcccaccgtg gccagtccca aaagcagcac cgtcacggtg 12480 gttccggtgg tcacaacaag cgtcgcaagg aagccgctgc tgcatcctcc agctccgacg 12540 aggacctgag cttccccggc gaggctgaac acggtcgtgc tcgcaagcgt ctgaagtccc 12600 acgtgaactc cgacggaggt agcggaggcc acgctggttc caaccagcag cagcaacagc 12660 gctacgacga gctgcgtgac gctatccacg agctgaagcg tgacctgttc gctgctcgcc 12720 agtcctccac cctgctgtct gctgctctgc cagctgccgc ttcttcctcc cctaccacca 12780 ccaccgtgtg cacccctact ggcgagctga cctctggtgg tggcgagact cccaccgctc 12840 tgctgtccgg tggtgctaag gtggccgagc gtgctcaggc tggtgtcgtg aacgcttcct 12900 gccgtctggc taccgcttcc ggttccgagg ctgccaccgc tggtccctct accgctggtt 12960 cctcatcctg cccagcttcc gtggtgctgg ctgccgctgc tgctcaagcc gccgctgctt 13020 cacagtcccc cccaaaggat atggtggacc tgaaccgtcg tatcttcgtg gctgctctga 13080 acaagctcga gtaataaaag cttgtcgaga agtactagag gatcataatc agccatacca 13140 catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac 13200 ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat 13260 aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg 13320 gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta 13380 gaagatccgg ctgctaacaa agcccgaaag gaagctggga atattaatag atcatggaga 13440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 13500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 13560 atccgccacc atggctgcta tggaagctaa catcttctgc accttcgacc acaagctgtc 13620 tatcgctgac gtgggcaagc tgaccaagct ggtggctgct gtggtgccca tcccccagcg 13680 tctgcacctg atcaagcact accagctggg cctgcaccag ttcgtggacc acacccgtgg 13740 ttacgtgcgt ctgcgtggcc tgctgcgtaa catgaccctg accctgatgc gtcgtgtcga 13800 gggcaaccag atcctgctgc acgtgcccac ccacggcctg ctgtacaccg tgctgaacac 13860 cggtcccgtg acctgggaga agggcgacgc tctgtgcgtg ctgccccccc tgttccacgg 13920 tcccctggct cgtgaaaacc tgttgaccct gggccagtgg gagctggtgc tgccctggat 13980 cgtgcccatg cccctggctc tggaaatcaa ccagcgcctg ctgatcatgg gcctgttctc 14040 cctggaccgt tcctacgaag aagtgaaggc tgctgtccag cagctgcaga ccatcacctt 14100 ccgtgacgct accttcacca tccccgaccc cgtgatcgac cagcacctcc tgatcgacat 14160 gaagaccgct tgcctgtcca tgtccatggt ggctaacctg gcttccgagc tgaccatgac 14220 ctacgtccgc aagctggctt tggaggactc ttccatgctg ctggtcaagt gccaagagct 14280 gctgatgcgt ctggaccgcg agcgttccgt gggcgagcct cgtactcccg ctcgtcctca 14340 gcacgtgtcc cccgacgacg agatcgctcg tctgtccgct ctgttcgtga tgctgcgtca 14400 gctggacgac ctgatccgcg agcaggtcgt gttcaccgtg tgcgacgtga gcccagacaa 14460 caagtccgct acctgcatct tcaagggcta aggcgcgcca agcttgtcga gaagtactag 14520 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 14580 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 14640 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 14700 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 14760 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 14820 gttggctgct gccaccgctg agcaataact atcataaccc ctaggggcct ctaaacgggt 14880 cttgaggggt tttttgctga aaggaggaac tatatccgga tctgaacagg agggacagct 14940 gatagaaaca gaagccactg gagcacctca aaaacaccat catacactaa atcagtaagt 15000 tggcagcatc acccgacgca ctttgcgccg aataaatacc tgtgacggaa gatcacttcg 15060 cagaataaat aaatcctggt gtccctgttg ataccgggaa gccctgggcc aacttttggc 15120 gaaaatgaga cgttgatcgg cacgtaagag gttccaactt tcaccataat gaaataagat 15180 cactaccggg cgtatttttt gagttatcga gattttcagg agctaaggaa gctaaaatgg 15240 agaaaaaaat cactggatat accaccgttg atatatccca atggcatcgt aaagaacatt 15300 ttgaggcatt tcagtcagtt gctcaatgta cctataacca gaccgttcag ctggatatta 15360 cggccttttt aaagaccgta aagaaaaata agcacaagtt ttatccggcc tttattcaca 15420 ttcttgcccg cctgatgaat gctcatccgg aattccgtat ggcaatgaaa gacggtgagc 15480 tggtgatatg ggatagtgtt cacccttgtt acaccgtttt ccatgagcaa actgaaacgt 15540 tttcatcgct ctggagtgaa taccacgacg atttccggca gtttctacac atatattcgc 15600 aagatgtggc gtgttacggt gaaaacctgg cctatttccc taaagggttt attgagaata 15660 tgtttttcgt ctcagccaat ccctgggtga gtttcaccag ttttgattta aacgtggcca 15720 atatggacaa cttcttcgcc cccgttttca ccatgggcaa atattatacg caaggcgaca 15780 aggtgctgat gccgctggcg attcaggttc atcatgccgt ttgtgatggc ttccatgtcg 15840 gcagaatgct taatgaatta caacagtact gcgatgagtg gcagggcggg gcgtaatttt 15900 tttaaggcag ttattggtgc ccttaaacgc ctggttgcta cgcctgaata agtgataata 15960 agcggatgaa tggcagaaat tcgaaagcaa attcgacccg gtcgtcggtt cagggcaggg 16020 tcgttaaata gccgcttatg tctattgctg gtttaccggt ttattgacta ccggaagcag 16080 tgtgaccgtg tgcttctcaa atgcctgagg ccagtttgct caggctctcc ccgtggaggt 16140 aataattgac gatatgatca tttattctgc ctcccagctg acattcatcc ggggtcagca 16200 ccgtttctgc ggactggctt tctacgtgtt ccgcttcctt tagcagccct tgcgccctga 16260 gtgcttgcgg cagcgtgaag ctaattctgt cagccgttaa gtgttcctgt gtcactcaaa 16320 attgctttga gaggctctaa gggcttctca gtgcgttaca tccctggctt gttgtccaca 16380 accgttaaac cttaaaagct ttaaaagcct tatatattct tttttttctt ataaaactta 16440 aaaccttaga ggctatttaa gttgctgatt tatattaatt ttattgttca aacatgagag 16500 cttagtacgt gaaacatgag agcttagtac gttagccatg agagcttagt acgttagcca 16560 tgagggttta gttcgttaaa catgagagct tagtacgtta aacatgagag cttagtacgt 16620 gaaacatgag agcttagtac gtactatcaa caggttgaac tgctgatcaa cagatcctct 16680 acgcggccgc ggtaccataa cttcgtatag catacattat acgaagttat ctggtttaaa 16740 cgtacccgta gtggctatgg cagggcttgc cgccccgacg ttggctgcga gccctgggcc 16800 ttcacccgaa cttgggggtt ggggtgggga aaaggaagaa acgcgggcgt attggtccca 16860 atggggtctc ggtggggtat cgacagagtg ccagccctgg gaccgaaccc cgcgtttatg 16920 aacaaacgac ccaacacccg tgcgttttat tctgtctttt tattgccgtc atagcgcggg 16980 ttccttccgg tattgtctcc ttccgtgttt cagttagcct cccccatctc ccggtaccgc 17040 atgctatgca tcagctgcta gcttagcgag cgtccacagc ctggggaccg taacgggagt 17100 gagcgggcag gttcacacgg gtctgcttca gctcaggggg caggccagcg tagtacttgt 17160 ccaggtgacg cagcaggggg gggtccagct ggtgacgcag gcagaattcc ttcacagcgt 17220 tgtacaggcc gtagaacagg gtgataccct cgggagcagc agcggtggac acgggcagac 17280 gcacagcacg gttggtacgg gtagcctcgt tacggatagc caccaccacg ttgaacaggg 17340 aggggggcac cagctcgaaa cccagcacgt gttcggtgaa gatggaacga ccgtaggaca 17400 gacgagtcag gtcgtaacca cggcacaggt cgtccacgca agtgtacaca gcgggggaac 17460 cgtcgccgca ctcggagtaa ccgcgcatca cggtcatcca acggggagcg gtgtcggagg 17520 acagcagggt cagcagagca cgcagctggt cggggttgtt gtacagcagg gccagggtgt 17580 ccaggaaagc gtcgtccagc agcacggagt tagcagcctc gggggtcacg ggacggtaac 17640 ggatcagctg ggacagggga ccgtccctac gggtcacgtt gaccagggga cgcagccagg 17700 actcgtactt gtcgccctgg aacacctctc ccagcaggca acgacgggtc agctcggggc 17760 actcagcggg caccttctca gccacggtgg gagccacgga cacggtagcg gaggacacga 17820 tgggcagcag caggcagcac cacagcagag ccacgggacc gggggagaag gagaaaccgc 17880 agtcgggacg acggcacatg gtggctcgag atcccgggtg atcaagtctt cgtcgagtga 17940 ttgtaaataa aatgtaattt acagtatagt attttaatta atatacaaat gatttgataa 18000 taattcttat ttaactataa tatattgtgt tgggttgaat taaaggtccg tatactagta 18060 tcgattcgcg acctactccg gaatattaat agatcatgga gataattaaa atgataacca 18120 tctcgcaaat aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat 18180 aaatattccg gattattcat accgtcccac catcgggcgc ggatccgcca ccatgtcccc 18240 caagaacctg acccccttcc tgaccgctct gtggctgctg ctgggccact cccgtgtgcc 18300 tcgtgtgcgt gctgaggaat gctgcgagtt catcaacgtg aaccaccccc ccgagcgctg 18360 ctacgacttc aagatgtgca accgtttcac cgtggctctg cgttgccccg acggcgaagt 18420 gtgctactcc cccgaaaaga ccgctgagat ccgtggtatc gtgaccacca tgacccactc 18480 cctgacccgt caggtggtgc acaacaagct gacctcttgc aactacaacc ccctgtacct 18540 cgaggctgac ggtcgtatcc gttgcggcaa ggtcaacgac aaggctcagt acctgctggg 18600 tgctgctggt tccgtgccct accgttggat caacctcgag tacgacaaga tcacccgtat 18660 cgtgggcctg gaccagtacc tcgagtccgt gaagaagcac aagcgtctgg acgtgtgccg 18720 tgctaagatg ggttacatgc tgcagtaaaa gcttgtcgag aagtactaga ggatcataat 18780 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 18840 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 18900 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 18960 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 19020 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 19080 tggctagctt tgtttaactt taagaaggag atacatctag accggaatat taatagatca 19140 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 19200 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 19260 gcgcggatcc gccaccatgc tgcgtctgct gctgcgtcac cacttccact gcctgctgct 19320 gtgcgctgtg tgggctaccc cctgcctggc ttccccttgg tccaccctga ccgctaacca 19380 gaacccctcc ccaccctggt ccaagctgac ctactccaag ccccacgacg ctgctacctt 19440 ctactgcccc ttcctgtacc catccccccc tcgttcccca ctgcagttct ccggtttcca 19500 gcgtgtgctg accggtcccg agtgccgtaa cgagactctg tacctgctgt acaaccgcga 19560 gggccagacc ctggtcgaga ggtcctccac ctgggtcaag aaggtcatct ggtacttgtc 19620 cggtcgtaac cagaccatcc tgcagcgtat gccccgtacc gcttccaagc cctccgacgg 19680 caacgtgcag atctccgtcg aggacgctaa gatcttcggt gctcacatgg tgcccaagca 19740 gaccaagctg ctgcgtttcg tggtcaacga cggcacccgt taccagatgt gcgtgatgaa 19800 gctcgagtcc tgggctcacg tgttccgtga ctactccgtg tccttccaag tgcgcctgac 19860 cttcaccgag gctaacaacc agacctacac cttctgcacc caccccaacc tgatcgtgta 19920 aaagcttgtc gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt 19980 acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat 20040 tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 20100 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 20160 caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta 20220 acaaagcccg aaaggaagct gagttggctg ctgggtgcct aatgagtgag ctaactcaca 20280 ttaattgccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 20340 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 20400 ggattattca taccgtccca ccatcgggcg cggatccgcc accatgcgtc tgtgccgtgt 20460 gtggctgtcc gtgtgcctgt gcgctgtggt gctgggccag tgccagcgtg aaaccgctga 20520 gaagaacgac tactaccgtg tgccccacta ctgggacgct tgctcccgtg ctctgcccga 20580 ccagacccgt tacaagtacg tcgagcagct ggtggacctg accctgaact accactacga 20640 cgcttcccac ggcctggaca acttcgacgt gctgaagcgt atcaacgtga ccgaggtgtc 20700 cctgctgatc tccgacttcc gtcgtcagaa ccgtcgtggt ggcaccaaca agcgtaccac 20760 cttcaacgct gctggttccc tggctcccca cgctcgttcc ctcgagttct ccgtgcgtct 20820 gttcgctaac taaaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt 20880 tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa 20940 aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag 21000 caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt 21060 gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag 21120 atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat 21180 aactatcata acccccggaa tattaataga tcatggagat aattaaaatg ataaccatct 21240 cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa 21300 tattccggat tattcatacc gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg 21360 aattcaaagg cctaccgtcg acgccaccat ggaatcccgt atctggtgcc tggtcgtgtg 21420 cgtgaacctg tgcatcgtgt gcctgggtgc tgctgtgtcc tcctcctcca cccgtggcac 21480 ctccgctacc cactcccacc actcctccca caccacctcc gccgctcact cccgttccgg 21540 ttccgtgtcc cagcgtgtga cctcctccca gaccgtgtcc cacggtgtca acgagactat 21600 ctacaacacc accctgaagt acggcgacgt cgtgggtgtc aacaccacca agtaccccta 21660 ccgtgtgtgc tccatggctc agggcaccga cctgatccgt ttcgagcgta acatcgtgtg 21720 cacctccatg aagcccatca acgaggacct ggacgagggt atcatggtgg tgtacaagcg 21780 caacatcgtg gctcacacct tcaaggtccg cgtgtaccag aaggtgctga ccttccgtcg 21840 ttcctacgct tacatccaca ccacttacct gctgggttcc aacaccgagt acgtggcccc 21900 tcccatgtgg gagatccacc acatcaactc ccactcccag tgctactcct cttactcccg 21960 tgtgatcgct ggcaccgtgt tcgtggctta ccaccgtgac tcctacgaga acaagaccat 22020 gcagctgatg cccgacgact actccaacac ccactccacc cgttacgtga ccgtgaagga 22080 ccagtggcac tcccgtggtt ccacctggct gtaccgtgaa acctgcaacc tgaactgcat 22140 ggtcaccatc accaccgctc gttccaagta cccttaccac ttcttcgcta cctccaccgg 22200 cgacgtggtg gacatctccc ccttctacaa cggtactaac cgtaacgctt cctacttcgg 22260 cgagaacgct gacaagttct tcatcttccc caactacacc atcgtgtccg acttcggtcg 22320 tcccaactcc gctctggaaa cccaccgtct ggtggctttc ttggagcgtg ctgactccgt 22380 gatctcctgg gacatccagg acgagaagaa cgtgacctgc cagctgacct tctgggaggc 22440 ttccgagcgt accatccgtt ccgaggctga ggactcctac cacttctcca gcgctaagat 22500 gaccgctacc ttcctgtcca agaaacaaga ggtcaacatg tccgactccg ccctggactg 22560 cgtgcgtgac gaggctatca acaagctgca gcagatcttc aacacctcct acaaccagac 22620 ctacgagaag tacggaaacg tgtccgtgtt cgagactacc ggtggcctgg tggtgttctg 22680 gcagggtatc aagcagaagt ccctggtcga gctggaacgt ctggctaacc gttcctccct 22740 gaacctgacc cacaaccgta ccaagcgttc caccgacggc aacaacgcta ctcacctgtc 22800 caacatggaa tccgtgcaca acctggtgta cgctcagctg cagttcacct acgacaccct 22860 gcgcggttac atcaaccgtg ctctggctca gatcgctgag gcttggtgcg tggaccagcg 22920 tcgtaccctg gaagtgttca aggaactgtc caagatcaac ccctccgcta tcctgtccgc 22980 catctacaac aagcctatcg ctgctcgttt catgggcgac gtgctgggcc tggcttcctg 23040 cgtgaccatc aaccagactt ccgtgaaggt gctgcgtgac atgaacgtga aggaatcccc 23100 cggtcgttgc tactcccgtc ccgtggtcat cttcaacttc gctaactcct cctacgtgca 23160 gtacggccag ctgggcgagg acaacgagat cctgctgggc aaccaccgta ccgaggaatg 23220 ccagctgccc tccctgaaga tcttcatcgc tggcaactcc gcttacgaat acgtggacta 23280 cctgttcaag cgcatgatcg acctgtcctc catctctacc gtggactcca tgatcgctct 23340 ggacatcgac cccctggaaa acaccgactt ccgtgtgctg gaactgtact cccagaagga 23400 actgcgttcc atcaacgtgt tcgacctgga agagatcatg cgcgagttca actcctacaa 23460 gcagcgtgtt aagtacgtcg aggacaaggt ggtggacccc ctgcccccct acctgaaggg 23520 actggacgac ctgatgtccg gcctgggagc tgccggcaag gctgtgggtg tcgctatcgg 23580 tgctgtgggt ggtgctgtgg cttccgtggt cgagggtgtc gccaccttcc tgaagaaccc 23640 cttcggtgct ttcaccatca tcctggtggc tatcgctgtg gtcatcatca tctacctgat 23700 ctacacccgt cagcgtcgtc tgtgcatgca gcccctgcag aacctgttcc cctacctggt 23760 gtccgctgac ggtactaccg tgacctccgg caacaccaag gacacctccc tgcaggctcc 23820 cccatcctac gaggaatccg tctacaactc cggtcgcaag ggtcccggtc ccccttcctc 23880 cgacgcttct accgctgctc ccccatacac caacgagcag gcttaccaga tgctgctggc 23940 tctcgtgcgt ctggacgctg agcagcgtgc acagcagaac ggcaccgact ccctggacgg 24000 ccagaccgga acccaggaca agggccagaa gcccaacctg ctggaccgtc tgcgtcaccg 24060 caagaacggt taccgtcacc tgaaggactc cgacgaggaa gagaacgtct aaggcgcgcc 24120 aagcttgtcg agaagtacta gagatcataa tcagccatac cacatttgta gaggttttac 24180 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 24240 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 24300 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 24360 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 24420 aaagcccgaa aggaagctgg gaatattaat agatcatgga gataattaaa atgataacca 24480 tctcgcaaat aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat 24540 aaatattccg gattattcat accgtcccac catcgggcgc ggatccgcca ccatgcgtcc 24600 cggcctgccc tcctacctga tcgtgctggc tgtgtgcctg ctgtcccacc tcctgtcctc 24660 ccgttacggt gctgaggcta tctccgagcc cctggacaag gctttccacc tcctgctgaa 24720 cacctacggt cgtcctatcc gtttcctgcg cgagaacacc acccagtgca cctacaactc 24780 ctccctgcgc aactccaccg tcgtccgcga gaacgctatc tccttcaact tcttccagtc 24840 ctacaaccag tactacgtgt tccacatgcc ccgttgcctg ttcgctggtc ccctggctga 24900 gcagttcctg aaccaggtgg acctgaccga gactctcgag cgttaccagc agcgtctgaa 24960 cacttacgct ctggtgtcca aggacctggc ttcctaccgt tccttcagcc agcagctgaa 25020 ggctcaggac tccctgggcg agcagcccac cactgtgcct ccccctatcg acctgtccat 25080 cccccacgtg tggatgcccc cccagaccac tcctcacggc tggaccgagt cccacaccac 25140 ctccggactg caccgtcccc acttcaacca gacctgcatc ctgttcgacg gtcacgacct 25200 gctgttctcc accgtgaccc cctgcctgca ccagggcttc tacctcatcg acgagctgcg 25260 ttacgtgaag atcaccctga ccgaggattt cttcgtggtc accgtgtcca tcgacgacga 25320 cacccccatg ctgctgatct tcggtcacct cccccgtgtg ctgttcaagg ctccctacca 25380 gcgtgacaac ttcatcctgc gtcagaccga gaagcacgag ctgctggtgc tggtcaagaa 25440 ggaccagctg aaccgtcact cttacctgaa ggaccccgac ttcctggacg ctgctctgga 25500 cttcaactac ctggacctgt ccgctctgct gaggaactcc ttccaccgtt acgctgtgga 25560 cgtgctgaag tccggtcgtt gccagatgct ggaccgtcgt accgtcgaga tggctttcgc 25620 ttacgccctg gctctgttcg ctgctgctcg tcaagaagag gctggcgctc aggtgtccgt 25680 gccccgtgct ctggaccgtc aggctgctct gctgcagatc caagagttca tgatcacttg 25740 cctgtcccag accccccctc gtaccaccct gctgctgtac cccaccgctg tggacctggc 25800 taagcgtgct ctgtggaccc ccaaccagat caccgacatc acctccctcg tgcgtctggt 25860 gtacatcctg tccaagcaga accagcagca cctgatcccc cagtgggctc tgcgtcagat 25920 cgctgacttc gctctgaagc tgcacaagac ccacctggct tcattcctca gcgctttcgc 25980 tcgccaagag ctgtacctga tgggttccct ggtgcactcc atgctggtgc acaccaccga 26040 gcgtcgcgag atcttcatcg tggaaaccgg cctgtgctcc ctggccgagc tgtcccactt 26100 cacccagctg ctggctcacc cccaccacga gtacctgtcc gacctgtaca ccccctgctc 26160 ctcttccggt cgtcgtgacc actccctgga acgtctgacc cgtctgttcc ccgacgctac 26220 cgtgcctacc accgtgcctg ctgctctgtc catcctgtct accatgcagc cctccaccct 26280 ggaaaccttc cccgacctgt tctgcctgcc tctgggcgag tccttctccg ctctgaccgt 26340 gtccgagcac gtgtcctacg tggtcaccaa ccagtacctg atcaagggca tctcctaccc 26400 cgtgtccacc accgtcgtgg gccagtccct gatcatcacc cagaccgact cccagaccaa 26460 gtgcgagctg acccgtaaca tgcacaccac tcactccatc accgctgctc tgaacatctc 26520 cctcgagaac tgcgctttct gccagtccgc tctgttggag tacgacgaca ctcagggtgt 26580 catcaacatc atgtacatgc acgactccga cgacgtgctg ttcgctctgg acccctacaa 26640 cgaggtggtg gtgtcctccc cccgtaccca ctacctgatg ctgctgaaga acggcaccgt 26700 gctggaagtg accgacgtgg tggtggacgc taccgaccgt ctgctgatga tgtccgtgta 26760 cgctctgtcc gctatcatcg gcatctacct gctgtaccgt atgctgaaga cctgctaagg 26820 cgccaagctt tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg 26880 ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg 26940 caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca 27000 tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac 27060 tcatcaatgt atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct 27120 gctaacaaag cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca 27180 taacccctag gagatccgaa ccagataagt gaaatctagt tccaaactat tttgtcattt 27240 ttaattttcg tattagctta cgacgctaca cccagttccc atctattttg tcactcttcc 27300 ctaaataatc cttaaaaact ccatttccac ccctcccagt tcccaactat tttgtccgcc 27360 caca 27364 <210> 50 <211> 27364 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 50 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttac tgcagccacc accacaggga gttcagggtg gacaggttca 2400 cagcacgacg gtgctcaggg ggggtcaggt tgccgtaggt ggaggactgc aggctgaagt 2460 tacggatctc agacaggaac agcagggagt ccaggtagtc ccacatgggg tcgatgaagg 2520 tgcgctggaa acgggtggat ggggaggtgg gggtggtctt gttgttgtcg gaagcagtct 2580 cgttctcgac gggcatggtg tcgttgtagt acagggagga catgtccagg gtgccgtaga 2640 tggtgtaggg agtctcgtta cggatcagca cgtgagtgtt cttcatgaac tcggacacag 2700 cggtacggtt acggttgggc ttgcagaagg gctcgtcacg gtaacgcagg gtggtgtaca 2760 cccaggtagc caggtccttc agctgagtgg tcaggataga cttcatgaag ttctcgtcgg 2820 gacggtaacc gatggtagag gtggggatac gggtgggcac gatgggggag taggtcacgt 2880 tggtggaaac gttgaagatg gtggaggtgt aggaggagta gggggtagta gtgctgacgc 2940 gggacttctt ggagatggac ttcacgggag cctgcttgcg cttcagcttg cgcatggtgt 3000 tcttcagctt ggtggagttg atgtacttgg gcacacggaa gatgttacgg gacatagcgt 3060 tgaccaggta gaaggaacgg gtgcagttgc gctgagcgta acgcagcagc agagcagcca 3120 ggcccaggaa gtagatagtc tgggagtcca cgttgacctt ggaggggccc acgtacagct 3180 tggtgttcca acggggcacg ttgaagaaca tggggttgaa ggtggtgaag ttgccgcagt 3240 tttcctcgcc ggtgttgtta cgacgggaca cgttcagcat ctcggacagg caggtcatgg 3300 aggggatggt gccgcaagag gggggacgga aggtgatctt ctggccggtg tggttgtact 3360 cggagtacac gtacttagcg ggcttgcgca gctgggtggt gtggaagtcg aaccacaggt 3420 gggtgatgga gtggttacgg atgggaccag ccaggatgga gttggggggg aactgcttca 3480 tctcgacggt gatgttgtac agcttctgct ggctggggaa ggtgaagaac ttgtagtagt 3540 cgccggtctt ggaagccagc tcttgcagga tacgcagctt cagctggcgt tcctcttcct 3600 tagccttctg ggacttcaca cggaaacgag ccacagcgat cttgcagttg atgaagctga 3660 acagcaggaa ggtcagggac atcaggaaga acaggttgaa cacgccacgc atctcgccct 3720 tgcgacccat ggtggcctcg agatcccggg tgatcaagtc ttcgtcgagt gattgtaaat 3780 aaaatgtaat ttacagtata gtattttaat taatatacaa atgatttgat aataattctt 3840 atttaactat aatatattgt gttgggttga attaaaggtc cgtatactag tatcgattcg 3900 cgacctactc cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa 3960 ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc 4020 cggattattc ataccgtccc accatcgggc gcggatccgc caccatggaa aactggtccg 4080 ctctggaact gctgcccaag gtcggaatcc ctaccgactt cctgacccac gtcaagacct 4140 ccgctggcga ggaaatgttc gaggctctga ggatctacta cggcgacgac cccgagcgtt 4200 acaacatcca cttcgaggct atcttcggca ccttctgcaa ccgtctggaa tgggtgtact 4260 tcctgacttc cggcctggct gctgctgctc acgctatcaa gttccacgac ctgaacaagc 4320 tgaccaccgg caagatgctg ttccacgtgc aagtgccccg tgtggcttcc ggtgctggcc 4380 tgcctacctc ccgtcagacc accatcatgg tcaccaagta ctccgagaag tcccccatca 4440 ccatcccttt cgagctgtcc gctgcttgcc tgacttacct gcgtgaaacc ttcgagggca 4500 ccatcctgga caagatcctg aacgtcgagg ctatgcacac cgtgctgcgt gctctgaaga 4560 acaccgctga cgctatggaa cgtggcctga tccacagctt cctccagacc ctgctgagga 4620 aggctccccc ctacttcgtg gtgcagaccc tggtcgagaa cgctaccctg gctcgtcagg 4680 ctctgaaccg tatccagcgc tccaacatcc tgcagtcctt caaggctaag atgctggcta 4740 ccctgttcct gctgaaccgt acccgtgacc gtgactacgt gctgaagttc ctgacccgtc 4800 tggctgaggc tgctaccgac tccatcctcg acaaccctac tacctacacc acctcctccg 4860 gtgctaagat ctccggtgtc atggtgtcca ccgctaacgt gatgcagatc atcatgtccc 4920 tgctgtcctc ccacatcact aaggaaaccg tgtccgctcc cgctacctac ggcaacttcg 4980 tgctgtcccc cgagaacgct gtgaccgcta tctcctacca ctctatcctg gctgacttca 5040 actcctacaa ggctcacctg acctccggcc agccccacct ccccaacgac tccctgagcc 5100 aggctggtgc tcactccctg acccccctgt ccatggacgt gatccgtctg ggcgaaaaga 5160 ccgtgatcat ggaaaacctg cgtcgcgtgt acaagaacac cgacaccaag gaccccctgg 5220 aacgtaacgt ggacctgacc ttcttcttcc ccgtgggcct gtacctgccc gaggaccgtg 5280 gttacaccac cgtcgagtcc aaggtcaagc tgaacgacac cgtgcgtaac gctctgccca 5340 ccaccgctta cctgctgaac agggaccgtg ctgtgcaaaa gatcgacttc gtggacgctc 5400 tcaagaccct gtgccacccc gtgctgcacg agcctgctcc atgcctgcag gctttcaccg 5460 agcgtggtcc cccatccgag cccgctatgc agcgtctgct ggaatgccgt ttccagcaag 5520 agcccatggg tggtgctgct cgtcgtatcc cccacttcta ccgtgtgcgc cgcgaggtgc 5580 cccgtaccgt gaacgagatg aagcaggact tcgtggtcac cgacttctac aaggttggaa 5640 acatcaccct gtacaccgag ctgcaccctt tcttcgactt cacccactgc caagagaact 5700 ccgagactgt ggctctgtgc accccccgta tcgtgatcgg caacctgccc gacggcctgg 5760 ctcccggtcc cttccacgag ctgaggacct gggagatcat ggaacacatg cgcctgcgtc 5820 ccccacccga ctacgaggaa accctgcgtc tgttcaagac caccgtgacc tcccccaact 5880 accccgagct gtgctacctg gtggacgtgc tggtgcacgg caacgctgac gctttcctgc 5940 tgatccgcgc tttcatcgct cgttgcatcg tgaacatgtt ccacacccgt cagctgctgg 6000 tgttcgctca ctcctacgct ctggtcaccc tgatcgctga gcacctggct gacggtgctc 6060 tgccccccca gctcctgttc cactaccgta acctggtggc tgtgctgcgc ctggtcaccc 6120 gtatctccgc tctgcccggc ctgaacaacg gccagctggc tgaggaaccc ctgtccgctt 6180 acgtgaacgc tctgcacgac cacaggctgt ggcccccctt cgtgacccac ctccctcgta 6240 acatggaagg tgtccaggtg gtggctgatc gtcagcccct gaaccccgct aacatcgagg 6300 ctcgtcacca cggtgtctcc gacgtgcccc gtctgggtgc tatggacgct gacgagcccc 6360 tgttcgtgga cgactaccgt gctaccgacg acgagtggac cctgcaaaag gtgttctacc 6420 tgtgcctgat ccccgctatg accaacaacc gtgcttgcgg cctgggcctg aacctcaaga 6480 ctctgctggt ggacctgttc taccgtcccg ccttcctgct catgcccgct gctaccgctg 6540 tgtccacctc cggcaccacc tccaaggaat ccacctctgg tgtcaccccc gaggactccg 6600 tggctgctca gcgtcaggct gtgggcgaga tgctgaccga gctggtcgag gacgtggcca 6660 ccgacgctca cacccctctg ctgcaggctt gccgcgagct gttcctggct gtgcagttcg 6720 tgggcgagca cgtgaaggtg ctggaagtgc gtgctcccct ggaccacgct cagaggcagg 6780 gactgcccga cttcatctcc cgtcagcatg tgctgtacaa cggttgctgc gtcgtgaccg 6840 ctcctaagac cctgatcgag tactccctgc ccgtgccctt ccaccgtttc tactccaacc 6900 ccaccatctg cgctgctctg tccgacgaca tcaagcgtta cgtgaccgag ttcccccact 6960 accatagaca cgatggtggt ttccccctgc ccaccgcttt cgctcacgag taccacaact 7020 ggctgcgtag ccccttctcc cgttactccg ctacctgccc caacgtgctg cactccgtga 7080 tgaccctggc tgctatgctg tacaagatct cccccgtgtc cctggtgctg cagaccaagg 7140 ctcacatcca ccccggtttc gctctgaccg ctgtgcgtac cgacaccttc gaggtggaca 7200 tgctgctgta ctccggcaag tcctgcacct ccgtcatcat caacaacccc atcgtgacca 7260 aggaagagag ggacatctcc accacctacc acgtgaccca gaacatcaac accgtggaca 7320 tgggcctggg ttacacctcc aacacttgcg tggcctacgt gaaccgcgtc cgcaccgaca 7380 tgggtgtccg tgtgcaggac ctgttccgtg tgttccccat gaacgtgtac cgccacgatg 7440 aggtggaccg ttggatcagg cacgctgctg gcgtcgagcg tccccagctg ctggacaccg 7500 agactatctc catgctgacc ttcggttcca tgtccgagcg caacgctgct gctaccgtgc 7560 acggccagaa ggctgtctgc gagctgatcc tgacccctgt gactatggac gtgaactact 7620 tcaagatcac caacaaccct cgtggtcgtg cttcctgcat gctgggcgtg gacccctacg 7680 acaccgaggc tgccaccaag gctatctacg accaccgcga ggctgacgct cagaccttcg 7740 ctgctaccca caacccatgg gcttcccagg ctggttgcct gtccgacgtc ctgtacaaca 7800 cccgtcaccg cgagcgtctg ggctacaact ccaagttcta ctccccctgc gctcagtact 7860 tcaacaccga ggaaatcatc gctgccaaca agaccctctt caagaccatc gacgagtacc 7920 tgctgcgcgc taaggactgc atccgtggcg acaccgacac tcagtacgtg tgcgtcgagg 7980 gaaccgagca gctgatcgag aacccttgcc gtctgaccca agaggctctg cccatcctgt 8040 ccaccaccac cctggctctg atggaaacta agctgaaggg tggcgctggt gctttcgcta 8100 cctccgagac tcacttcggc aactacgtcg tgggagagat catccccctg cagcagtcca 8160 tgctgttcaa cagctaagag ctcaagcttg tcgagaagta ctagaggatc ataatcagcc 8220 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 8280 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 8340 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 8400 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 8460 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgtggct 8520 agctttgttt aactttaaga aggagataca tctagaccgg aatattaata gatcatggag 8580 ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt 8640 ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg 8700 gatcccggtc cgaagcgcgc ggaattcaaa ggcctacgtc gacgccacca tggaatcccg 8760 tggtcgtcgt tgccccgaga tgatctccgt gctgggtccc atctccggtc acgtcctgaa 8820 ggctgtgttc tcccgtggcg acacccccgt gctgccccac gaaactcgtc tgctgcagac 8880 cggtatccac gtgcgtgtgt cccagccctc cctgatcctg gtgtcccagt acacccccga 8940 ctccacccct tgccaccgcg gagacaacca gctgcaggtc cagcacacct acttcaccgg 9000 ttccgaggtc gagaacgtgt ccgtgaacgt gcacaacccc accggtcgtt ccatctgccc 9060 ctcccaagag cccatgtcca tctacgtgta cgctctgccc ctgaagatgc tgaacatccc 9120 ctccatcaac gtgcaccact acccctccgc tgctgagcgc aagcaccgtc acctccccgt 9180 ggctgacgct gtgatccacg cttccggcaa gcagatgtgg caggctcgtc tgaccgtgtc 9240 cggcctggct tggacccgtc agcagaacca gtggaaggaa cccgacgtgt actacacctc 9300 cgctttcgtg ttccccacca aggacgtggc cctgcgtcac gtcgtgtgcg ctcacgaact 9360 cgtgtgctcc atggaaaaca cccgtgctac caagatgcaa gtgatcggcg accagtacgt 9420 gaaggtgtac ctggaatcct tctgcgagga cgtgccctcc ggcaagctgt tcatgcacgt 9480 gaccctgggt tccgacgtgg aagaggacct gaccatgacc cgtaaccccc agcccttcat 9540 gcgtccccac gagcgtaacg gtttcaccgt gctgtgcccc aagaacatga tcatcaagcc 9600 cggcaagatc tcccacatca tgctggacgt ggccttcacc tcccacgagc acttcggcct 9660 gctgtgccct aagtccatcc ccggcctgtc catctccggc aacctgctga tgaacggcca 9720 gcagatcttc ctggaagtgc aggctatccg tgaaaccgtc gagctgcgtc agtacgaccc 9780 tgtggctgct ctgttcttct tcgacatcga cctgctgctg cagcgtggtc cccagtactc 9840 cgagcacccc accttcacca gccagtaccg tatccagggc aagctggaat accgtcacac 9900 ctgggaccgt cacgacgagg gtgctgctca gggcgacgac gacgtgtgga cctccggttc 9960 cgactccgac gaggaactgg tcaccaccga gcgcaagacc ccccgtgtga ccggtggtgg 10020 tgctatggct ggtgcttcca cctccgctgg tcgcaagcgc aagtccgctt cctccgctac 10080 cgcttgcacc gctggtgtca tgacccgtgg tcgcctgaag gctgagtcca ccgtggctcc 10140 cgaagaggac actgacgagg actccgacaa cgagatccac aaccccgctg tgttcacctg 10200 gcccccctgg caggctggta tcctggctcg taacctggtg cccatggtgg ctaccgtgca 10260 gggccagaac ctgaagtacc aagagttctt ctgggacgcc aacgacatct accgtatctt 10320 cgctgagctg gaaggcgtgt ggcagcccgc tgctcagccc aagcgtcgtc gtcaccgtca 10380 ggacgctctg cctggtccct gtatcgcttc cacccccaag aagcaccgcg gctaaaagct 10440 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 10500 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 10560 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 10620 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 10680 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 10740 cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca taaccggaat 10800 attaatagat catggagata attaaaatga taaccatctc gcaaataaat aagtatttta 10860 ctgttttcgt aacagttttg taataaaaaa acctataaat attccggatt attcataccg 10920 tcccaccatc gggcgcggat cccggtccga agcgcgcgga attcgccacc atgaccatgg 10980 acgagcagca gccccaggct gtgacccccg tgtacgtggg cggtttcctg gctcgttacg 11040 accagtcccc cgacgaggct gagctgctgc tgccacgtga cgtggtcgaa cactggctgc 11100 acgctcaggg ccagggacag ccttccctgt ccgtggctct gcccctgaac atcaaccacg 11160 acgacaccgc tgtcgtgggt cacgtggccg ctatgcagtc cgtgcgtgac ggcctgttct 11220 gcctgggttg cgtgacctcc ccccgtttcc tggaaatcgt gcgtcgtgct tccgagaagt 11280 ccgagctggt gtcccgtggt cccgtgtccc cactgcagcc cgacaaggtg gtcgagttcc 11340 tgtccggttc ctacgctggc ctgtccctgt catcccgtcg ttgcgacgac gtcgaggctg 11400 ctacctccct gagcggctcc gagactaccc ccttcaagca cgtggccctg tgctccgtgg 11460 gtcgtaggcg tggaaccctg gctgtgtacg gtcgtgaccc cgagtgggtc acccagcgtt 11520 tccccgacct gaccgctgct gaccgtgacg gactgcgtgc tcagtggcag cgttgcggtt 11580 ccaccgctgt ggacgcttcc ggcgacccct tccgttccga ctcctacggc ctgctgggca 11640 actccgtgga cgctctgtac atccgcgagc gtctgcccaa gctgcgttac gacaagcagc 11700 tcgtgggtgt caccgagcgc gagtcctacg tgaaggcttc cgtgtccccc gaggctgctt 11760 gcgacatcaa ggctgcttcc gctgagcgtt ctggcgacag ccgctcccag gctgctactc 11820 ctgctgctgg tgctcgtgtg ccctccagct ccccatcccc acctgtcgag cctccctccc 11880 ccgtgcaacc tcctgctctg cctgcttccc cctccgtgct gcctgctgag tccagcccct 11940 ccctgtcacc ctctgagcct gctgaggctg cctccatgtc ccaccctctg agcgctgctg 12000 tgactgctgc taccgctccc cctggtgcta ctgtggctgg tgcttccccc gctgtgcctt 12060 ccctggcttg gcctcacgac ggtgtctacc tgcccaagga cgctttcttc tccctgctgg 12120 gcgcttcccg ttccgctgct cccgtgatgt accccggtgc tgtggctgct ccccccagcg 12180 cttcacctgc tcctctgccc ctgccctcct accccgcttc ctacggtgct cccgtcgtgg 12240 gttacgacca gctggctgct cgtcacttcg ctgactacgt ggacccccac taccccggct 12300 ggggtcgtcg ttacgagccc gctccttccc tgcacccatc ctaccctgtg ccccctcctc 12360 catcacccgc ttactaccgt cgtcgtgact cccccggtgg catggacgag cctccatctg 12420 gatgggagcg ttacgacggt tcccaccgtg gccagtccca aaagcagcac cgtcacggtg 12480 gttccggtgg tcacaacaag cgtcgcaagg aagccgctgc tgcatcctcc agctccgacg 12540 aggacctgag cttccccggc gaggctgaac acggtcgtgc tcgcaagcgt ctgaagtccc 12600 acgtgaactc cgacggaggt agcggaggcc acgctggttc caaccagcag cagcaacagc 12660 gctacgacga gctgcgtgac gctatccacg agctgaagcg tgacctgttc gctgctcgcc 12720 agtcctccac cctgctgtct gctgctctgc cagctgccgc ttcttcctcc cctaccacca 12780 ccaccgtgtg cacccctact ggcgagctga cctctggtgg tggcgagact cccaccgctc 12840 tgctgtccgg tggtgctaag gtggccgagc gtgctcaggc tggtgtcgtg aacgcttcct 12900 gccgtctggc taccgcttcc ggttccgagg ctgccaccgc tggtccctct accgctggtt 12960 cctcatcctg cccagcttcc gtggtgctgg ctgccgctgc tgctcaagcc gccgctgctt 13020 cacagtcccc cccaaaggat atggtggacc tgaaccgtcg tatcttcgtg gctgctctga 13080 acaagctcga gtaataaaag cttgtcgaga agtactagag gatcataatc agccatacca 13140 catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac 13200 ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat 13260 aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg 13320 gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta 13380 gaagatccgg ctgctaacaa agcccgaaag gaagctggga atattaatag atcatggaga 13440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 13500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 13560 atccgccacc atggctgcta tggaagctaa catcttctgc accttcgacc acaagctgtc 13620 tatcgctgac gtgggcaagc tgaccaagct ggtggctgct gtggtgccca tcccccagcg 13680 tctgcacctg atcaagcact accagctggg cctgcaccag ttcgtggacc acacccgtgg 13740 ttacgtgcgt ctgcgtggcc tgctgcgtaa catgaccctg accctgatgc gtcgtgtcga 13800 gggcaaccag atcctgctgc acgtgcccac ccacggcctg ctgtacaccg tgctgaacac 13860 cggtcccgtg acctgggaga agggcgacgc tctgtgcgtg ctgccccccc tgttccacgg 13920 tcccctggct cgtgaaaacc tgttgaccct gggccagtgg gagctggtgc tgccctggat 13980 cgtgcccatg cccctggctc tggaaatcaa ccagcgcctg ctgatcatgg gcctgttctc 14040 cctggaccgt tcctacgaag aagtgaaggc tgctgtccag cagctgcaga ccatcacctt 14100 ccgtgacgct accttcacca tccccgaccc cgtgatcgac cagcacctcc tgatcgacat 14160 gaagaccgct tgcctgtcca tgtccatggt ggctaacctg gcttccgagc tgaccatgac 14220 ctacgtccgc aagctggctt tggaggactc ttccatgctg ctggtcaagt gccaagagct 14280 gctgatgcgt ctggaccgcg agcgttccgt gggcgagcct cgtactcccg ctcgtcctca 14340 gcacgtgtcc cccgacgacg agatcgctcg tctgtccgct ctgttcgtga tgctgcgtca 14400 gctggacgac ctgatccgcg agcaggtcgt gttcaccgtg tgcgacgtga gcccagacaa 14460 caagtccgct acctgcatct tcaagggcta aggcgcgcca agcttgtcga gaagtactag 14520 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 14580 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 14640 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 14700 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 14760 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 14820 gttggctgct gccaccgctg agcaataact atcataaccc ctaggggcct ctaaacgggt 14880 cttgaggggt tttttgctga aaggaggaac tatatccgga tctgaacagg agggacagct 14940 gatagaaaca gaagccactg gagcacctca aaaacaccat catacactaa atcagtaagt 15000 tggcagcatc acccgacgca ctttgcgccg aataaatacc tgtgacggaa gatcacttcg 15060 cagaataaat aaatcctggt gtccctgttg ataccgggaa gccctgggcc aacttttggc 15120 gaaaatgaga cgttgatcgg cacgtaagag gttccaactt tcaccataat gaaataagat 15180 cactaccggg cgtatttttt gagttatcga gattttcagg agctaaggaa gctaaaatgg 15240 agaaaaaaat cactggatat accaccgttg atatatccca atggcatcgt aaagaacatt 15300 ttgaggcatt tcagtcagtt gctcaatgta cctataacca gaccgttcag ctggatatta 15360 cggccttttt aaagaccgta aagaaaaata agcacaagtt ttatccggcc tttattcaca 15420 ttcttgcccg cctgatgaat gctcatccgg aattccgtat ggcaatgaaa gacggtgagc 15480 tggtgatatg ggatagtgtt cacccttgtt acaccgtttt ccatgagcaa actgaaacgt 15540 tttcatcgct ctggagtgaa taccacgacg atttccggca gtttctacac atatattcgc 15600 aagatgtggc gtgttacggt gaaaacctgg cctatttccc taaagggttt attgagaata 15660 tgtttttcgt ctcagccaat ccctgggtga gtttcaccag ttttgattta aacgtggcca 15720 atatggacaa cttcttcgcc cccgttttca ccatgggcaa atattatacg caaggcgaca 15780 aggtgctgat gccgctggcg attcaggttc atcatgccgt ttgtgatggc ttccatgtcg 15840 gcagaatgct taatgaatta caacagtact gcgatgagtg gcagggcggg gcgtaatttt 15900 tttaaggcag ttattggtgc ccttaaacgc ctggttgcta cgcctgaata agtgataata 15960 agcggatgaa tggcagaaat tcgaaagcaa attcgacccg gtcgtcggtt cagggcaggg 16020 tcgttaaata gccgcttatg tctattgctg gtttaccggt ttattgacta ccggaagcag 16080 tgtgaccgtg tgcttctcaa atgcctgagg ccagtttgct caggctctcc ccgtggaggt 16140 aataattgac gatatgatca tttattctgc ctcccagctg acattcatcc ggggtcagca 16200 ccgtttctgc ggactggctt tctacgtgtt ccgcttcctt tagcagccct tgcgccctga 16260 gtgcttgcgg cagcgtgaag ctaattctgt cagccgttaa gtgttcctgt gtcactcaaa 16320 attgctttga gaggctctaa gggcttctca gtgcgttaca tccctggctt gttgtccaca 16380 accgttaaac cttaaaagct ttaaaagcct tatatattct tttttttctt ataaaactta 16440 aaaccttaga ggctatttaa gttgctgatt tatattaatt ttattgttca aacatgagag 16500 cttagtacgt gaaacatgag agcttagtac gttagccatg agagcttagt acgttagcca 16560 tgagggttta gttcgttaaa catgagagct tagtacgtta aacatgagag cttagtacgt 16620 gaaacatgag agcttagtac gtactatcaa caggttgaac tgctgatcaa cagatcctct 16680 acgcggccgc ggtaccataa cttcgtatag catacattat acgaagttat ctggtttaaa 16740 cgtacccgta gtggctatgg cagggcttgc cgccccgacg ttggctgcga gccctgggcc 16800 ttcacccgaa cttgggggtt ggggtgggga aaaggaagaa acgcgggcgt attggtccca 16860 atggggtctc ggtggggtat cgacagagtg ccagccctgg gaccgaaccc cgcgtttatg 16920 aacaaacgac ccaacacccg tgcgttttat tctgtctttt tattgccgtc atagcgcggg 16980 ttccttccgg tattgtctcc ttccgtgttt cagttagcct cccccatctc ccggtaccgc 17040 atgctatgca tcagctgcta gcttagcgag cgtccacagc ctggggaccg taacgggagt 17100 gagcgggcag gttcacacgg gtctgcttca gctcaggggg caggccagcg tagtacttgt 17160 ccaggtgacg cagcaggggg gggtccagct ggtgacgcag gcagaattcc ttcacagcgt 17220 tgtacaggcc gtagaacagg gtgataccct cgggagcagc agcggtggac acgggcagac 17280 gcacagcacg gttggtacgg gtagcctcgt tacggatagc caccaccacg ttgaacaggg 17340 aggggggcac cagctcgaaa cccagcacgt gttcggtgaa gatggaacga ccgtaggaca 17400 gacgagtcag gtcgtaacca cggcacaggt cgtccacgca agtgtacaca gcgggggaac 17460 cgtcgccgca ctcggagtaa ccgcgcatca cggtcatcca acggggagcg gtgtcggagg 17520 acagcagggt cagcagagca cgcagctggt cggggttgtt gtacagcagg gccagggtgt 17580 ccaggaaagc gtcgtccagc agcacggagt tagcagcctc gggggtcacg ggacggtaac 17640 ggatcagctg ggacagggga ccgtccctac gggtcacgtt gaccagggga cgcagccagg 17700 actcgtactt gtcgccctgg aacacctctc ccagcaggca acgacgggtc agctcggggc 17760 actcagcggg caccttctca gccacggtgg gagccacgga cacggtagcg gaggacacga 17820 tgggcagcag caggcagcac cacagcagag ccacgggacc gggggagaag gagaaaccgc 17880 agtcgggacg acggcacatg gtggctcgag atcccgggtg atcaagtctt cgtcgagtga 17940 ttgtaaataa aatgtaattt acagtatagt attttaatta atatacaaat gatttgataa 18000 taattcttat ttaactataa tatattgtgt tgggttgaat taaaggtccg tatactagta 18060 tcgattcgcg acctactccg gaatattaat agatcatgga gataattaaa atgataacca 18120 tctcgcaaat aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat 18180 aaatattccg gattattcat accgtcccac catcgggcgc ggatccgcca ccatgaactc 18240 caaggacctg acccccttcc tgaccaccct gtggctgctg ctggaccact cccgtgtgcc 18300 tcgtgtgcgt gctgaggaat gctgcgaagt gatcaacgtg aaccaccccc ccgagcgctg 18360 ctacgacttc aagatgtgca acctgttcac cgtggctctg cgttgccccg acggcgaagt 18420 gtgctactcc cccgaaaaga ccgctgagat ccgtggtatc gtgaccacca tgacccactc 18480 cctgacccgt caagtgatcc acaacaagct gaccagctgc aactacaacc ccctgtacct 18540 cgaggctgac ggtcgtatcc gttgcggcaa ggtgtccgac aaggctcagt acctgctggg 18600 tgctgctggt tccgtgccct accgttggat caacctcgag tacgacaaga tcacccgtat 18660 cgtgggcctg gaccagtacc tcgagtccgt gaagaagcac aagcgtctgg acgtgtgccg 18720 tgctaagatg ggttacatgc tgcagtaaaa gcttgtcgag aagtactaga ggatcataat 18780 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 18840 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 18900 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 18960 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 19020 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 19080 tggctagctt tgtttaactt taagaaggag atacatctag accggaatat taatagatca 19140 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 19200 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 19260 gcgcggatcc gccaccatgc tgcgtctgct gctgcgtcac cacttccact gcctgctgct 19320 gtgcgctgtg tgggctaccc cctgcctggc ttccccttgg tccaccctga ccgctaacca 19380 gaacccctcc ccaccctggt ccaagctgac ctactccaag ccccacgacg ctgctacctt 19440 ctactgcccc ttcctgtacc catccccccc tcgttcccca ctgcagttct ccggtttcca 19500 gcgtgtgctg accggtcccg agtgccgtaa cgagactctg tacctgctgt acaaccgcga 19560 gggccagacc ctggtcgaga ggtcctccac ctgggtcaag aaggtcatct ggtacttgtc 19620 cggtcgtaac cagaccatcc tgcagcgtat gccccgtacc gcttccaagc cctccgacgg 19680 caacgtgcag atctccgtcg aggacgctaa gatcttcggt gctcacatgg tgcccaagca 19740 gaccaagctg ctgcgtttcg tggtcaacga cggcacccgt taccagatgt gcgtgatgaa 19800 gctcgagtcc tgggctcacg tgttccgtga ctactccgtg tccttccaag tgcgcctgac 19860 cttcaccgag gctaacaacc agacctacac cttctgcacc caccccaacc tgatcgtgta 19920 aaagcttgtc gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt 19980 acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat 20040 tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 20100 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 20160 caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta 20220 acaaagcccg aaaggaagct gagttggctg ctgggtgcct aatgagtgag ctaactcaca 20280 ttaattgccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 20340 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 20400 ggattattca taccgtccca ccatcgggcg cggatccgcc accatgcgtc tgtgccgtgt 20460 gtggctgtcc gtgtgcctgt gcgctgtggt gctgggccag tgccagcgtg aaaccgctga 20520 gaagaacgac tactaccgtg tgccccacta ctgggacgct tgctcccgtg ctctgcccga 20580 ccagacccgt tacaagtacg tcgagcagct ggtggacctg accctgaact accactacga 20640 cgcttcccac ggcctggaca acttcgacgt gctgaagcgt atcaacgtga ccgaggtgtc 20700 cctgctgatc tccgacttcc gtcgtcagaa ccgtcgtggt ggcaccaaca agcgtaccac 20760 cttcaacgct gctggttccc tggctcccca cgctcgttcc ctcgagttct ccgtgcgtct 20820 gttcgctaac taaaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt 20880 tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa 20940 aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag 21000 caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt 21060 gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag 21120 atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat 21180 aactatcata acccccggaa tattaataga tcatggagat aattaaaatg ataaccatct 21240 cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa 21300 tattccggat tattcatacc gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg 21360 aattcaaagg cctaccgtcg acgccaccat ggaatcccgt atctggtgcc tggtcgtgtg 21420 cgtgaacctg tgcatcgtgt gcctgggtgc tgctgtgtcc tcctcctcca cccgtggcac 21480 ctccgctacc cactcccacc actcctccca caccacctcc gccgctcact cccgttccgg 21540 ttccgtgtcc cagcgtgtga cctcctccca gaccgtgtcc cacggtgtca acgagactat 21600 ctacaacacc accctgaagt acggcgacgt cgtgggtgtc aacaccacca agtaccccta 21660 ccgtgtgtgc tccatggctc agggcaccga cctgatccgt ttcgagcgta acatcgtgtg 21720 cacctccatg aagcccatca acgaggacct ggacgagggt atcatggtgg tgtacaagcg 21780 caacatcgtg gctcacacct tcaaggtccg cgtgtaccag aaggtgctga ccttccgtcg 21840 ttcctacgct tacatccaca ccacttacct gctgggttcc aacaccgagt acgtggcccc 21900 tcccatgtgg gagatccacc acatcaactc ccactcccag tgctactcct cttactcccg 21960 tgtgatcgct ggcaccgtgt tcgtggctta ccaccgtgac tcctacgaga acaagaccat 22020 gcagctgatg cccgacgact actccaacac ccactccacc cgttacgtga ccgtgaagga 22080 ccagtggcac tcccgtggtt ccacctggct gtaccgtgaa acctgcaacc tgaactgcat 22140 ggtcaccatc accaccgctc gttccaagta cccttaccac ttcttcgcta cctccaccgg 22200 cgacgtggtg gacatctccc ccttctacaa cggtactaac cgtaacgctt cctacttcgg 22260 cgagaacgct gacaagttct tcatcttccc caactacacc atcgtgtccg acttcggtcg 22320 tcccaactcc gctctggaaa cccaccgtct ggtggctttc ttggagcgtg ctgactccgt 22380 gatctcctgg gacatccagg acgagaagaa cgtgacctgc cagctgacct tctgggaggc 22440 ttccgagcgt accatccgtt ccgaggctga ggactcctac cacttctcca gcgctaagat 22500 gaccgctacc ttcctgtcca agaaacaaga ggtcaacatg tccgactccg ccctggactg 22560 cgtgcgtgac gaggctatca acaagctgca gcagatcttc aacacctcct acaaccagac 22620 ctacgagaag tacggaaacg tgtccgtgtt cgagactacc ggtggcctgg tggtgttctg 22680 gcagggtatc aagcagaagt ccctggtcga gctggaacgt ctggctaacc gttcctccct 22740 gaacctgacc cacaaccgta ccaagcgttc caccgacggc aacaacgcta ctcacctgtc 22800 caacatggaa tccgtgcaca acctggtgta cgctcagctg cagttcacct acgacaccct 22860 gcgcggttac atcaaccgtg ctctggctca gatcgctgag gcttggtgcg tggaccagcg 22920 tcgtaccctg gaagtgttca aggaactgtc caagatcaac ccctccgcta tcctgtccgc 22980 catctacaac aagcctatcg ctgctcgttt catgggcgac gtgctgggcc tggcttcctg 23040 cgtgaccatc aaccagactt ccgtgaaggt gctgcgtgac atgaacgtga aggaatcccc 23100 cggtcgttgc tactcccgtc ccgtggtcat cttcaacttc gctaactcct cctacgtgca 23160 gtacggccag ctgggcgagg acaacgagat cctgctgggc aaccaccgta ccgaggaatg 23220 ccagctgccc tccctgaaga tcttcatcgc tggcaactcc gcttacgaat acgtggacta 23280 cctgttcaag cgcatgatcg acctgtcctc catctctacc gtggactcca tgatcgctct 23340 ggacatcgac cccctggaaa acaccgactt ccgtgtgctg gaactgtact cccagaagga 23400 actgcgttcc atcaacgtgt tcgacctgga agagatcatg cgcgagttca actcctacaa 23460 gcagcgtgtt aagtacgtcg aggacaaggt ggtggacccc ctgcccccct acctgaaggg 23520 actggacgac ctgatgtccg gcctgggagc tgccggcaag gctgtgggtg tcgctatcgg 23580 tgctgtgggt ggtgctgtgg cttccgtggt cgagggtgtc gccaccttcc tgaagaaccc 23640 cttcggtgct ttcaccatca tcctggtggc tatcgctgtg gtcatcatca tctacctgat 23700 ctacacccgt cagcgtcgtc tgtgcatgca gcccctgcag aacctgttcc cctacctggt 23760 gtccgctgac ggtactaccg tgacctccgg caacaccaag gacacctccc tgcaggctcc 23820 cccatcctac gaggaatccg tctacaactc cggtcgcaag ggtcccggtc ccccttcctc 23880 cgacgcttct accgctgctc ccccatacac caacgagcag gcttaccaga tgctgctggc 23940 tctcgtgcgt ctggacgctg agcagcgtgc acagcagaac ggcaccgact ccctggacgg 24000 ccagaccgga acccaggaca agggccagaa gcccaacctg ctggaccgtc tgcgtcaccg 24060 caagaacggt taccgtcacc tgaaggactc cgacgaggaa gagaacgtct aaggcgcgcc 24120 aagcttgtcg agaagtacta gagatcataa tcagccatac cacatttgta gaggttttac 24180 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 24240 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 24300 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 24360 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 24420 aaagcccgaa aggaagctgg gaatattaat agatcatgga gataattaaa atgataacca 24480 tctcgcaaat aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat 24540 aaatattccg gattattcat accgtcccac catcgggcgc ggatccgcca ccatgcgtcc 24600 cggcctgccc tcctacctga tcgtgctggc tgtgtgcctg ctgtcccacc tcctgtcctc 24660 ccgttacggt gctgaggcta tctccgagcc cctggacaag gctttccacc tcctgctgaa 24720 cacctacggt cgtcctatcc gtttcctgcg cgagaacacc acccagtgca cctacaactc 24780 ctccctgcgc aactccaccg tcgtccgcga gaacgctatc tccttcaact tcttccagtc 24840 ctacaaccag tactacgtgt tccacatgcc ccgttgcctg ttcgctggtc ccctggctga 24900 gcagttcctg aaccaggtgg acctgaccga gactctcgag cgttaccagc agcgtctgaa 24960 cacttacgct ctggtgtcca aggacctggc ttcctaccgt tccttcagcc agcagctgaa 25020 ggctcaggac tccctgggcg agcagcccac cactgtgcct ccccctatcg acctgtccat 25080 cccccacgtg tggatgcccc cccagaccac tcctcacggc tggaccgagt cccacaccac 25140 ctccggactg caccgtcccc acttcaacca gacctgcatc ctgttcgacg gtcacgacct 25200 gctgttctcc accgtgaccc cctgcctgca ccagggcttc tacctcatcg acgagctgcg 25260 ttacgtgaag atcaccctga ccgaggattt cttcgtggtc accgtgtcca tcgacgacga 25320 cacccccatg ctgctgatct tcggtcacct cccccgtgtg ctgttcaagg ctccctacca 25380 gcgtgacaac ttcatcctgc gtcagaccga gaagcacgag ctgctggtgc tggtcaagaa 25440 ggaccagctg aaccgtcact cttacctgaa ggaccccgac ttcctggacg ctgctctgga 25500 cttcaactac ctggacctgt ccgctctgct gaggaactcc ttccaccgtt acgctgtgga 25560 cgtgctgaag tccggtcgtt gccagatgct ggaccgtcgt accgtcgaga tggctttcgc 25620 ttacgccctg gctctgttcg ctgctgctcg tcaagaagag gctggcgctc aggtgtccgt 25680 gccccgtgct ctggaccgtc aggctgctct gctgcagatc caagagttca tgatcacttg 25740 cctgtcccag accccccctc gtaccaccct gctgctgtac cccaccgctg tggacctggc 25800 taagcgtgct ctgtggaccc ccaaccagat caccgacatc acctccctcg tgcgtctggt 25860 gtacatcctg tccaagcaga accagcagca cctgatcccc cagtgggctc tgcgtcagat 25920 cgctgacttc gctctgaagc tgcacaagac ccacctggct tcattcctca gcgctttcgc 25980 tcgccaagag ctgtacctga tgggttccct ggtgcactcc atgctggtgc acaccaccga 26040 gcgtcgcgag atcttcatcg tggaaaccgg cctgtgctcc ctggccgagc tgtcccactt 26100 cacccagctg ctggctcacc cccaccacga gtacctgtcc gacctgtaca ccccctgctc 26160 ctcttccggt cgtcgtgacc actccctgga acgtctgacc cgtctgttcc ccgacgctac 26220 cgtgcctacc accgtgcctg ctgctctgtc catcctgtct accatgcagc cctccaccct 26280 ggaaaccttc cccgacctgt tctgcctgcc tctgggcgag tccttctccg ctctgaccgt 26340 gtccgagcac gtgtcctacg tggtcaccaa ccagtacctg atcaagggca tctcctaccc 26400 cgtgtccacc accgtcgtgg gccagtccct gatcatcacc cagaccgact cccagaccaa 26460 gtgcgagctg acccgtaaca tgcacaccac tcactccatc accgctgctc tgaacatctc 26520 cctcgagaac tgcgctttct gccagtccgc tctgttggag tacgacgaca ctcagggtgt 26580 catcaacatc atgtacatgc acgactccga cgacgtgctg ttcgctctgg acccctacaa 26640 cgaggtggtg gtgtcctccc cccgtaccca ctacctgatg ctgctgaaga acggcaccgt 26700 gctggaagtg accgacgtgg tggtggacgc taccgaccgt ctgctgatga tgtccgtgta 26760 cgctctgtcc gctatcatcg gcatctacct gctgtaccgt atgctgaaga cctgctaagg 26820 cgccaagctt tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg 26880 ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg 26940 caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca 27000 tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac 27060 tcatcaatgt atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct 27120 gctaacaaag cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca 27180 taacccctag gagatccgaa ccagataagt gaaatctagt tccaaactat tttgtcattt 27240 ttaattttcg tattagctta cgacgctaca cccagttccc atctattttg tcactcttcc 27300 ctaaataatc cttaaaaact ccatttccac ccctcccagt tcccaactat tttgtccgcc 27360 caca 27364 <210> 51 <211> 27385 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 51 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttac tgcagccacc accacaggga gttcagggtg gacaggttca 2400 cagcacgacg gtgctcaggg ggggtcaggt tgccgtaggt ggaggactgc aggctgaagt 2460 tacggatctc agacaggaac agcagggagt ccaggtagtc ccacatgggg tcgatgaagg 2520 tgcgctggaa acgggtggat ggggaggtgg gggtggtctt gttgttgtcg gaagcagtct 2580 cgttctcgac gggcatggtg tcgttgtagt acagggagga catgtccagg gtgccgtaga 2640 tggtgtaggg agtctcgtta cggatcagca cgtgagtgtt cttcatgaac tcggacacag 2700 cggtacggtt acggttgggc ttgcagaagg gctcgtcacg gtaacgcagg gtggtgtaca 2760 cccaggtagc caggtccttc agctgagtgg tcaggataga cttcatgaag ttctcgtcgg 2820 gacggtaacc gatggtagag gtggggatac gggtgggcac gatgggggag taggtcacgt 2880 tggtggaaac gttgaagatg gtggaggtgt aggaggagta gggggtagta gtgctgacgc 2940 gggacttctt ggagatggac ttcacgggag cctgcttgcg cttcagcttg cgcatggtgt 3000 tcttcagctt ggtggagttg atgtacttgg gcacacggaa gatgttacgg gacatagcgt 3060 tgaccaggta gaaggaacgg gtgcagttgc gctgagcgta acgcagcagc agagcagcca 3120 ggcccaggaa gtagatagtc tgggagtcca cgttgacctt ggaggggccc acgtacagct 3180 tggtgttcca acggggcacg ttgaagaaca tggggttgaa ggtggtgaag ttgccgcagt 3240 tttcctcgcc ggtgttgtta cgacgggaca cgttcagcat ctcggacagg caggtcatgg 3300 aggggatggt gccgcaagag gggggacgga aggtgatctt ctggccggtg tggttgtact 3360 cggagtacac gtacttagcg ggcttgcgca gctgggtggt gtggaagtcg aaccacaggt 3420 gggtgatgga gtggttacgg atgggaccag ccaggatgga gttggggggg aactgcttca 3480 tctcgacggt gatgttgtac agcttctgct ggctggggaa ggtgaagaac ttgtagtagt 3540 cgccggtctt ggaagccagc tcttgcagga tacgcagctt cagctggcgt tcctcttcct 3600 tagccttctg ggacttcaca cggaaacgag ccacagcgat cttgcagttg atgaagctga 3660 acagcaggaa ggtcagggac atcaggaaga acaggttgaa cacgccacgc atctcgccct 3720 tgcgacccat ggtggcctcg agatcccggg tgatcaagtc ttcgtcgagt gattgtaaat 3780 aaaatgtaat ttacagtata gtattttaat taatatacaa atgatttgat aataattctt 3840 atttaactat aatatattgt gttgggttga attaaaggtc cgtatactag tatcgattcg 3900 cgacctactc cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa 3960 ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc 4020 cggattattc ataccgtccc accatcgggc gcggatccgc caccatggaa aactggtccg 4080 ctctggaact gctgcccaag gtcggaatcc ctaccgactt cctgacccac gtcaagacct 4140 ccgctggcga ggaaatgttc gaggctctga ggatctacta cggcgacgac cccgagcgtt 4200 acaacatcca cttcgaggct atcttcggca ccttctgcaa ccgtctggaa tgggtgtact 4260 tcctgacttc cggcctggct gctgctgctc acgctatcaa gttccacgac ctgaacaagc 4320 tgaccaccgg caagatgctg ttccacgtgc aagtgccccg tgtggcttcc ggtgctggcc 4380 tgcctacctc ccgtcagacc accatcatgg tcaccaagta ctccgagaag tcccccatca 4440 ccatcccttt cgagctgtcc gctgcttgcc tgacttacct gcgtgaaacc ttcgagggca 4500 ccatcctgga caagatcctg aacgtcgagg ctatgcacac cgtgctgcgt gctctgaaga 4560 acaccgctga cgctatggaa cgtggcctga tccacagctt cctccagacc ctgctgagga 4620 aggctccccc ctacttcgtg gtgcagaccc tggtcgagaa cgctaccctg gctcgtcagg 4680 ctctgaaccg tatccagcgc tccaacatcc tgcagtcctt caaggctaag atgctggcta 4740 ccctgttcct gctgaaccgt acccgtgacc gtgactacgt gctgaagttc ctgacccgtc 4800 tggctgaggc tgctaccgac tccatcctcg acaaccctac tacctacacc acctcctccg 4860 gtgctaagat ctccggtgtc atggtgtcca ccgctaacgt gatgcagatc atcatgtccc 4920 tgctgtcctc ccacatcact aaggaaaccg tgtccgctcc cgctacctac ggcaacttcg 4980 tgctgtcccc cgagaacgct gtgaccgcta tctcctacca ctctatcctg gctgacttca 5040 actcctacaa ggctcacctg acctccggcc agccccacct ccccaacgac tccctgagcc 5100 aggctggtgc tcactccctg acccccctgt ccatggacgt gatccgtctg ggcgaaaaga 5160 ccgtgatcat ggaaaacctg cgtcgcgtgt acaagaacac cgacaccaag gaccccctgg 5220 aacgtaacgt ggacctgacc ttcttcttcc ccgtgggcct gtacctgccc gaggaccgtg 5280 gttacaccac cgtcgagtcc aaggtcaagc tgaacgacac cgtgcgtaac gctctgccca 5340 ccaccgctta cctgctgaac agggaccgtg ctgtgcaaaa gatcgacttc gtggacgctc 5400 tcaagaccct gtgccacccc gtgctgcacg agcctgctcc atgcctgcag gctttcaccg 5460 agcgtggtcc cccatccgag cccgctatgc agcgtctgct ggaatgccgt ttccagcaag 5520 agcccatggg tggtgctgct cgtcgtatcc cccacttcta ccgtgtgcgc cgcgaggtgc 5580 cccgtaccgt gaacgagatg aagcaggact tcgtggtcac cgacttctac aaggttggaa 5640 acatcaccct gtacaccgag ctgcaccctt tcttcgactt cacccactgc caagagaact 5700 ccgagactgt ggctctgtgc accccccgta tcgtgatcgg caacctgccc gacggcctgg 5760 ctcccggtcc cttccacgag ctgaggacct gggagatcat ggaacacatg cgcctgcgtc 5820 ccccacccga ctacgaggaa accctgcgtc tgttcaagac caccgtgacc tcccccaact 5880 accccgagct gtgctacctg gtggacgtgc tggtgcacgg caacgctgac gctttcctgc 5940 tgatccgcgc tttcatcgct cgttgcatcg tgaacatgtt ccacacccgt cagctgctgg 6000 tgttcgctca ctcctacgct ctggtcaccc tgatcgctga gcacctggct gacggtgctc 6060 tgccccccca gctcctgttc cactaccgta acctggtggc tgtgctgcgc ctggtcaccc 6120 gtatctccgc tctgcccggc ctgaacaacg gccagctggc tgaggaaccc ctgtccgctt 6180 acgtgaacgc tctgcacgac cacaggctgt ggcccccctt cgtgacccac ctccctcgta 6240 acatggaagg tgtccaggtg gtggctgatc gtcagcccct gaaccccgct aacatcgagg 6300 ctcgtcacca cggtgtctcc gacgtgcccc gtctgggtgc tatggacgct gacgagcccc 6360 tgttcgtgga cgactaccgt gctaccgacg acgagtggac cctgcaaaag gtgttctacc 6420 tgtgcctgat ccccgctatg accaacaacc gtgcttgcgg cctgggcctg aacctcaaga 6480 ctctgctggt ggacctgttc taccgtcccg ccttcctgct catgcccgct gctaccgctg 6540 tgtccacctc cggcaccacc tccaaggaat ccacctctgg tgtcaccccc gaggactccg 6600 tggctgctca gcgtcaggct gtgggcgaga tgctgaccga gctggtcgag gacgtggcca 6660 ccgacgctca cacccctctg ctgcaggctt gccgcgagct gttcctggct gtgcagttcg 6720 tgggcgagca cgtgaaggtg ctggaagtgc gtgctcccct ggaccacgct cagaggcagg 6780 gactgcccga cttcatctcc cgtcagcatg tgctgtacaa cggttgctgc gtcgtgaccg 6840 ctcctaagac cctgatcgag tactccctgc ccgtgccctt ccaccgtttc tactccaacc 6900 ccaccatctg cgctgctctg tccgacgaca tcaagcgtta cgtgaccgag ttcccccact 6960 accatagaca cgatggtggt ttccccctgc ccaccgcttt cgctcacgag taccacaact 7020 ggctgcgtag ccccttctcc cgttactccg ctacctgccc caacgtgctg cactccgtga 7080 tgaccctggc tgctatgctg tacaagatct cccccgtgtc cctggtgctg cagaccaagg 7140 ctcacatcca ccccggtttc gctctgaccg ctgtgcgtac cgacaccttc gaggtggaca 7200 tgctgctgta ctccggcaag tcctgcacct ccgtcatcat caacaacccc atcgtgacca 7260 aggaagagag ggacatctcc accacctacc acgtgaccca gaacatcaac accgtggaca 7320 tgggcctggg ttacacctcc aacacttgcg tggcctacgt gaaccgcgtc cgcaccgaca 7380 tgggtgtccg tgtgcaggac ctgttccgtg tgttccccat gaacgtgtac cgccacgatg 7440 aggtggaccg ttggatcagg cacgctgctg gcgtcgagcg tccccagctg ctggacaccg 7500 agactatctc catgctgacc ttcggttcca tgtccgagcg caacgctgct gctaccgtgc 7560 acggccagaa ggctgtctgc gagctgatcc tgacccctgt gactatggac gtgaactact 7620 tcaagatcac caacaaccct cgtggtcgtg cttcctgcat gctgggcgtg gacccctacg 7680 acaccgaggc tgccaccaag gctatctacg accaccgcga ggctgacgct cagaccttcg 7740 ctgctaccca caacccatgg gcttcccagg ctggttgcct gtccgacgtc ctgtacaaca 7800 cccgtcaccg cgagcgtctg ggctacaact ccaagttcta ctccccctgc gctcagtact 7860 tcaacaccga ggaaatcatc gctgccaaca agaccctctt caagaccatc gacgagtacc 7920 tgctgcgcgc taaggactgc atccgtggcg acaccgacac tcagtacgtg tgcgtcgagg 7980 gaaccgagca gctgatcgag aacccttgcc gtctgaccca agaggctctg cccatcctgt 8040 ccaccaccac cctggctctg atggaaacta agctgaaggg tggcgctggt gctttcgcta 8100 cctccgagac tcacttcggc aactacgtcg tgggagagat catccccctg cagcagtcca 8160 tgctgttcaa cagctaagag ctcaagcttg tcgagaagta ctagaggatc ataatcagcc 8220 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 8280 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 8340 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 8400 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 8460 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgtggct 8520 agctttgttt aactttaaga aggagataca tctagaccgg aatattaata gatcatggag 8580 ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt 8640 ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg 8700 gatcccggtc cgaagcgcgc ggaattcaaa ggcctacgtc gacgccacca tggaatcccg 8760 tggtcgtcgt tgccccgaga tgatctccgt gctgggtccc atctccggtc acgtcctgaa 8820 ggctgtgttc tcccgtggcg acacccccgt gctgccccac gaaactcgtc tgctgcagac 8880 cggtatccac gtgcgtgtgt cccagccctc cctgatcctg gtgtcccagt acacccccga 8940 ctccacccct tgccaccgcg gagacaacca gctgcaggtc cagcacacct acttcaccgg 9000 ttccgaggtc gagaacgtgt ccgtgaacgt gcacaacccc accggtcgtt ccatctgccc 9060 ctcccaagag cccatgtcca tctacgtgta cgctctgccc ctgaagatgc tgaacatccc 9120 ctccatcaac gtgcaccact acccctccgc tgctgagcgc aagcaccgtc acctccccgt 9180 ggctgacgct gtgatccacg cttccggcaa gcagatgtgg caggctcgtc tgaccgtgtc 9240 cggcctggct tggacccgtc agcagaacca gtggaaggaa cccgacgtgt actacacctc 9300 cgctttcgtg ttccccacca aggacgtggc cctgcgtcac gtcgtgtgcg ctcacgaact 9360 cgtgtgctcc atggaaaaca cccgtgctac caagatgcaa gtgatcggcg accagtacgt 9420 gaaggtgtac ctggaatcct tctgcgagga cgtgccctcc ggcaagctgt tcatgcacgt 9480 gaccctgggt tccgacgtgg aagaggacct gaccatgacc cgtaaccccc agcccttcat 9540 gcgtccccac gagcgtaacg gtttcaccgt gctgtgcccc aagaacatga tcatcaagcc 9600 cggcaagatc tcccacatca tgctggacgt ggccttcacc tcccacgagc acttcggcct 9660 gctgtgccct aagtccatcc ccggcctgtc catctccggc aacctgctga tgaacggcca 9720 gcagatcttc ctggaagtgc aggctatccg tgaaaccgtc gagctgcgtc agtacgaccc 9780 tgtggctgct ctgttcttct tcgacatcga cctgctgctg cagcgtggtc cccagtactc 9840 cgagcacccc accttcacca gccagtaccg tatccagggc aagctggaat accgtcacac 9900 ctgggaccgt cacgacgagg gtgctgctca gggcgacgac gacgtgtgga cctccggttc 9960 cgactccgac gaggaactgg tcaccaccga gcgcaagacc ccccgtgtga ccggtggtgg 10020 tgctatggct ggtgcttcca cctccgctgg tcgcaagcgc aagtccgctt cctccgctac 10080 cgcttgcacc gctggtgtca tgacccgtgg tcgcctgaag gctgagtcca ccgtggctcc 10140 cgaagaggac actgacgagg actccgacaa cgagatccac aaccccgctg tgttcacctg 10200 gcccccctgg caggctggta tcctggctcg taacctggtg cccatggtgg ctaccgtgca 10260 gggccagaac ctgaagtacc aagagttctt ctgggacgcc aacgacatct accgtatctt 10320 cgctgagctg gaaggcgtgt ggcagcccgc tgctcagccc aagcgtcgtc gtcaccgtca 10380 ggacgctctg cctggtccct gtatcgcttc cacccccaag aagcaccgcg gctaaaagct 10440 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 10500 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 10560 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 10620 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 10680 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 10740 cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca taaccggaat 10800 attaatagat catggagata attaaaatga taaccatctc gcaaataaat aagtatttta 10860 ctgttttcgt aacagttttg taataaaaaa acctataaat attccggatt attcataccg 10920 tcccaccatc gggcgcggat cccggtccga agcgcgcgga attcgccacc atgaccatgg 10980 acgagcagca gccccaggct gtgacccccg tgtacgtggg cggtttcctg gctcgttacg 11040 accagtcccc cgacgaggct gagctgctgc tgccacgtga cgtggtcgaa cactggctgc 11100 acgctcaggg ccagggacag ccttccctgt ccgtggctct gcccctgaac atcaaccacg 11160 acgacaccgc tgtcgtgggt cacgtggccg ctatgcagtc cgtgcgtgac ggcctgttct 11220 gcctgggttg cgtgacctcc ccccgtttcc tggaaatcgt gcgtcgtgct tccgagaagt 11280 ccgagctggt gtcccgtggt cccgtgtccc cactgcagcc cgacaaggtg gtcgagttcc 11340 tgtccggttc ctacgctggc ctgtccctgt catcccgtcg ttgcgacgac gtcgaggctg 11400 ctacctccct gagcggctcc gagactaccc ccttcaagca cgtggccctg tgctccgtgg 11460 gtcgtaggcg tggaaccctg gctgtgtacg gtcgtgaccc cgagtgggtc acccagcgtt 11520 tccccgacct gaccgctgct gaccgtgacg gactgcgtgc tcagtggcag cgttgcggtt 11580 ccaccgctgt ggacgcttcc ggcgacccct tccgttccga ctcctacggc ctgctgggca 11640 actccgtgga cgctctgtac atccgcgagc gtctgcccaa gctgcgttac gacaagcagc 11700 tcgtgggtgt caccgagcgc gagtcctacg tgaaggcttc cgtgtccccc gaggctgctt 11760 gcgacatcaa ggctgcttcc gctgagcgtt ctggcgacag ccgctcccag gctgctactc 11820 ctgctgctgg tgctcgtgtg ccctccagct ccccatcccc acctgtcgag cctccctccc 11880 ccgtgcaacc tcctgctctg cctgcttccc cctccgtgct gcctgctgag tccagcccct 11940 ccctgtcacc ctctgagcct gctgaggctg cctccatgtc ccaccctctg agcgctgctg 12000 tgactgctgc taccgctccc cctggtgcta ctgtggctgg tgcttccccc gctgtgcctt 12060 ccctggcttg gcctcacgac ggtgtctacc tgcccaagga cgctttcttc tccctgctgg 12120 gcgcttcccg ttccgctgct cccgtgatgt accccggtgc tgtggctgct ccccccagcg 12180 cttcacctgc tcctctgccc ctgccctcct accccgcttc ctacggtgct cccgtcgtgg 12240 gttacgacca gctggctgct cgtcacttcg ctgactacgt ggacccccac taccccggct 12300 ggggtcgtcg ttacgagccc gctccttccc tgcacccatc ctaccctgtg ccccctcctc 12360 catcacccgc ttactaccgt cgtcgtgact cccccggtgg catggacgag cctccatctg 12420 gatgggagcg ttacgacggt tcccaccgtg gccagtccca aaagcagcac cgtcacggtg 12480 gttccggtgg tcacaacaag cgtcgcaagg aagccgctgc tgcatcctcc agctccgacg 12540 aggacctgag cttccccggc gaggctgaac acggtcgtgc tcgcaagcgt ctgaagtccc 12600 acgtgaactc cgacggaggt agcggaggcc acgctggttc caaccagcag cagcaacagc 12660 gctacgacga gctgcgtgac gctatccacg agctgaagcg tgacctgttc gctgctcgcc 12720 agtcctccac cctgctgtct gctgctctgc cagctgccgc ttcttcctcc cctaccacca 12780 ccaccgtgtg cacccctact ggcgagctga cctctggtgg tggcgagact cccaccgctc 12840 tgctgtccgg tggtgctaag gtggccgagc gtgctcaggc tggtgtcgtg aacgcttcct 12900 gccgtctggc taccgcttcc ggttccgagg ctgccaccgc tggtccctct accgctggtt 12960 cctcatcctg cccagcttcc gtggtgctgg ctgccgctgc tgctcaagcc gccgctgctt 13020 cacagtcccc cccaaaggat atggtggacc tgaaccgtcg tatcttcgtg gctgctctga 13080 acaagctcga gtaataaaag cttgtcgaga agtactagag gatcataatc agccatacca 13140 catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac 13200 ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat 13260 aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg 13320 gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta 13380 gaagatccgg ctgctaacaa agcccgaaag gaagctggga atattaatag atcatggaga 13440 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 13500 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 13560 atccgccacc atggctgcta tggaagctaa catcttctgc accttcgacc acaagctgtc 13620 tatcgctgac gtgggcaagc tgaccaagct ggtggctgct gtggtgccca tcccccagcg 13680 tctgcacctg atcaagcact accagctggg cctgcaccag ttcgtggacc acacccgtgg 13740 ttacgtgcgt ctgcgtggcc tgctgcgtaa catgaccctg accctgatgc gtcgtgtcga 13800 gggcaaccag atcctgctgc acgtgcccac ccacggcctg ctgtacaccg tgctgaacac 13860 cggtcccgtg acctgggaga agggcgacgc tctgtgcgtg ctgccccccc tgttccacgg 13920 tcccctggct cgtgaaaacc tgttgaccct gggccagtgg gagctggtgc tgccctggat 13980 cgtgcccatg cccctggctc tggaaatcaa ccagcgcctg ctgatcatgg gcctgttctc 14040 cctggaccgt tcctacgaag aagtgaaggc tgctgtccag cagctgcaga ccatcacctt 14100 ccgtgacgct accttcacca tccccgaccc cgtgatcgac cagcacctcc tgatcgacat 14160 gaagaccgct tgcctgtcca tgtccatggt ggctaacctg gcttccgagc tgaccatgac 14220 ctacgtccgc aagctggctt tggaggactc ttccatgctg ctggtcaagt gccaagagct 14280 gctgatgcgt ctggaccgcg agcgttccgt gggcgagcct cgtactcccg ctcgtcctca 14340 gcacgtgtcc cccgacgacg agatcgctcg tctgtccgct ctgttcgtga tgctgcgtca 14400 gctggacgac ctgatccgcg agcaggtcgt gttcaccgtg tgcgacgtga gcccagacaa 14460 caagtccgct acctgcatct tcaagggcta aggcgcgcca agcttgtcga gaagtactag 14520 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 14580 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 14640 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 14700 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 14760 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 14820 gttggctgct gccaccgctg agcaataact atcataaccc ctaggggcct ctaaacgggt 14880 cttgaggggt tttttgctga aaggaggaac tatatccgga tctgaacagg agggacagct 14940 gatagaaaca gaagccactg gagcacctca aaaacaccat catacactaa atcagtaagt 15000 tggcagcatc acccgacgca ctttgcgccg aataaatacc tgtgacggaa gatcacttcg 15060 cagaataaat aaatcctggt gtccctgttg ataccgggaa gccctgggcc aacttttggc 15120 gaaaatgaga cgttgatcgg cacgtaagag gttccaactt tcaccataat gaaataagat 15180 cactaccggg cgtatttttt gagttatcga gattttcagg agctaaggaa gctaaaatgg 15240 agaaaaaaat cactggatat accaccgttg atatatccca atggcatcgt aaagaacatt 15300 ttgaggcatt tcagtcagtt gctcaatgta cctataacca gaccgttcag ctggatatta 15360 cggccttttt aaagaccgta aagaaaaata agcacaagtt ttatccggcc tttattcaca 15420 ttcttgcccg cctgatgaat gctcatccgg aattccgtat ggcaatgaaa gacggtgagc 15480 tggtgatatg ggatagtgtt cacccttgtt acaccgtttt ccatgagcaa actgaaacgt 15540 tttcatcgct ctggagtgaa taccacgacg atttccggca gtttctacac atatattcgc 15600 aagatgtggc gtgttacggt gaaaacctgg cctatttccc taaagggttt attgagaata 15660 tgtttttcgt ctcagccaat ccctgggtga gtttcaccag ttttgattta aacgtggcca 15720 atatggacaa cttcttcgcc cccgttttca ccatgggcaa atattatacg caaggcgaca 15780 aggtgctgat gccgctggcg attcaggttc atcatgccgt ttgtgatggc ttccatgtcg 15840 gcagaatgct taatgaatta caacagtact gcgatgagtg gcagggcggg gcgtaatttt 15900 tttaaggcag ttattggtgc ccttaaacgc ctggttgcta cgcctgaata agtgataata 15960 agcggatgaa tggcagaaat tcgaaagcaa attcgacccg gtcgtcggtt cagggcaggg 16020 tcgttaaata gccgcttatg tctattgctg gtttaccggt ttattgacta ccggaagcag 16080 tgtgaccgtg tgcttctcaa atgcctgagg ccagtttgct caggctctcc ccgtggaggt 16140 aataattgac gatatgatca tttattctgc ctcccagctg acattcatcc ggggtcagca 16200 ccgtttctgc ggactggctt tctacgtgtt ccgcttcctt tagcagccct tgcgccctga 16260 gtgcttgcgg cagcgtgaag ctaattctgt cagccgttaa gtgttcctgt gtcactcaaa 16320 attgctttga gaggctctaa gggcttctca gtgcgttaca tccctggctt gttgtccaca 16380 accgttaaac cttaaaagct ttaaaagcct tatatattct tttttttctt ataaaactta 16440 aaaccttaga ggctatttaa gttgctgatt tatattaatt ttattgttca aacatgagag 16500 cttagtacgt gaaacatgag agcttagtac gttagccatg agagcttagt acgttagcca 16560 tgagggttta gttcgttaaa catgagagct tagtacgtta aacatgagag cttagtacgt 16620 gaaacatgag agcttagtac gtactatcaa caggttgaac tgctgatcaa cagatcctct 16680 acgcggccgc ggtaccataa cttcgtatag catacattat acgaagttat ctggtttaaa 16740 cgtacccgta gtggctatgg cagggcttgc cgccccgacg ttggctgcga gccctgggcc 16800 ttcacccgaa cttgggggtt ggggtgggga aaaggaagaa acgcgggcgt attggtccca 16860 atggggtctc ggtggggtat cgacagagtg ccagccctgg gaccgaaccc cgcgtttatg 16920 aacaaacgac ccaacacccg tgcgttttat tctgtctttt tattgccgtc atagcgcggg 16980 ttccttccgg tattgtctcc ttccgtgttt cagttagcct cccccatctc ccggtaccgc 17040 atgctatgca tcagctgcta gcttagcgag cgtccacagc ctggggaccg taacgggagt 17100 gagcgggcag gttcacacgg gtctgcttca gctcaggggg caggccagcg tagtacttgt 17160 ccaggtgacg cagcaggggg gggtccagct ggtgacgcag gcagaattcc ttcacagcgt 17220 tgtacaggcc gtagaacagg gtgataccct cgggagcagc agcggtggac acgggcagac 17280 gcacagcacg gttggtacgg gtagcctcgt tacggatagc caccaccacg ttgaacaggg 17340 aggggggcac cagctcgaaa cccagcacgt gttcggtgaa gatggaacga ccgtaggaca 17400 gacgagtcag gtcgtaacca cggcacaggt cgtccacgca agtgtacaca gcgggggaac 17460 cgtcgccgca ctcggagtaa ccgcgcatca cggtcatcca acggggagcg gtgtcggagg 17520 acagcagggt cagcagagca cgcagctggt cggggttgtt gtacagcagg gccagggtgt 17580 ccaggaaagc gtcgtccagc agcacggagt tagcagcctc gggggtcacg ggacggtaac 17640 ggatcagctg ggacagggga ccgtccctac gggtcacgtt gaccagggga cgcagccagg 17700 actcgtactt gtcgccctgg aacacctctc ccagcaggca acgacgggtc agctcggggc 17760 actcagcggg caccttctca gccacggtgg gagccacgga cacggtagcg gaggacacga 17820 tgggcagcag caggcagcac cacagcagag ccacgggacc gggggagaag gagaaaccgc 17880 agtcgggacg acggcacatg gtggctcgag atcccgggtg atcaagtctt cgtcgagtga 17940 ttgtaaataa aatgtaattt acagtatagt attttaatta atatacaaat gatttgataa 18000 taattcttat ttaactataa tatattgtgt tgggttgaat taaaggtccg tatactagta 18060 tcgattcgcg acctactccg gaatattaat agatcatgga gataattaaa atgataacca 18120 tctcgcaaat aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat 18180 aaatattccg gattattcat accgtcccac catcgggcgc ggatccgcca ccatgaactc 18240 caaggacctg acccccttcc tgaccaccct gtggctgctg ctggaccact cccgtgtgcc 18300 tcgtgtgcgt gctgaggaat gctgcgaagt gatcaacgtg aaccaccccc ccgagcgctg 18360 ctacgacttc aagatgtgca acctgttcac cgtggctctg cgttgccccg acggcgaagt 18420 gtgctactcc cccgaaaaga ccgctgagat ccgtggtatc gtgaccacca tgacccactc 18480 cctgacccgt caagtgatcc acaacaagct gaccagctgc aactacaacc ccctgtacct 18540 cgaggctgac ggtcgtatcc gttgcggcaa ggtgtccgac aaggctcagt acctgctggg 18600 tgctgctggt tccgtgccct accgttggat caacctcgag tacgacaaga tcacccgtat 18660 cgtgggcctg gaccagtacc tcgagtccgt gaagaagcac aagcgtctgg acgtgtgccg 18720 tgctaagatg ggttacatgc tgcagtaaaa gcttgtcgag aagtactaga ggatcataat 18780 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 18840 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 18900 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 18960 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 19020 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 19080 tggctagctt tgtttaactt taagaaggag atacatctag accggaatat taatagatca 19140 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 19200 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 19260 gcgcggatcc gccaccatgc tgcgtctgct gctgcgtcac cacttccact gcctgctgct 19320 gtgcgctgtg tgggctaccc cctgcctggc ttccccctgg ttcaccctga ccgctaacca 19380 gaacccctcc ccaccctggt ccaagctgac ctaccccaag ccccacgacg ctgctacctt 19440 ctactgcccc ttcctgtacc catccccacc tcgttcccca tcccagttct ccggtttcca 19500 gcgtgtgtcc accggtcccg agtgccgtaa cgagactctg tacctgctgt acaaccgcga 19560 gggccagacc ctggtcgaga ggtcctccac ctgggtcaag aaggtcatct ggtacttgtc 19620 cggtcgtaac cagaccatcc tgcagcgtat gccccgtacc gcttccaagc cctccgacgg 19680 caacgtgcag atctccgtcg aggacgctaa gatcttcggt gctcacatgg tgcccaagca 19740 gaccaagctg ctgcgtttcg tggtcaacga cggcacccgt taccagatgt gcgtgatgaa 19800 gctggaatcc tgggctcacg tgttccgtga ctactccgtg tccttccaag tgcgcctgac 19860 cttcaccgag gctaacaacc agacctacac cttctgcacc caccccaacc tgatcgtgta 19920 agtcgacaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 19980 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 20040 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 20100 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 20160 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 20220 ctgctaacaa agcccgaaag gaagctgagt tggctgctgg gtgcctaatg agtgagctaa 20280 ctcacattaa ttgcccggaa tattaataga tcatggagat aattaaaatg ataaccatct 20340 cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa 20400 tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccaccg gatccgccac 20460 catgcgtctg tgccgtgtgt ggctgtccgt gtgcctgtgc gctgtggtgc tgggacagtg 20520 ccagcgtgaa accgctgaga agaacgacta ctaccgtgtg ccccactact gggacgcttg 20580 ctcccgtgct ctgcccgacc agacccgtta caagtacgtc gagcagctgg tggacctgac 20640 cctgaactac cactacgacg cttcccacgg cctggacaac ttcgacgtgc tgaagcgtat 20700 caacgtgacc gaggtgtccc tgctgatctc cgacttccgt cgtcagaacc gtcgtggtgg 20760 caccaacaag cgtaccacct tcaacgctgc tggttccctg gctccccacg ctcgttcctt 20820 ggagttctcc gtgcgtctgt tcgccaacta ataaaagctt gtcgagaagt actagaggat 20880 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 20940 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 21000 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 21060 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 21120 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 21180 ctgctgccac cgctgagcaa taactatcat aacccccgga atattaatag atcatggaga 21240 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 21300 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 21360 atcccggtcc gaagcgcgcg gaattcaaag gcctaccgtc gacgccacca tggaatcccg 21420 tatctggtgc ctggtcgtgt gcgtgaacct gtgcatcgtg tgcctgggtg ctgctgtgtc 21480 ctcctcctcc acccgtggca cctccgctac ccactcccac cactcctccc acaccacctc 21540 cgccgctcac tcccgttccg gttccgtgtc ccagcgtgtg acctcctccc agaccgtgtc 21600 ccacggtgtc aacgagacta tctacaacac caccctgaag tacggcgacg tcgtgggtgt 21660 caacaccacc aagtacccct accgtgtgtg ctccatggct cagggcaccg acctgatccg 21720 tttcgagcgt aacatcgtgt gcacctccat gaagcccatc aacgaggacc tggacgaggg 21780 tatcatggtg gtgtacaagc gcaacatcgt ggctcacacc ttcaaggtcc gcgtgtacca 21840 gaaggtgctg accttccgtc gttcctacgc ttacatccac accacttacc tgctgggttc 21900 caacaccgag tacgtggccc ctcccatgtg ggagatccac cacatcaact cccactccca 21960 gtgctactcc tcttactccc gtgtgatcgc tggcaccgtg ttcgtggctt accaccgtga 22020 ctcctacgag aacaagacca tgcagctgat gcccgacgac tactccaaca cccactccac 22080 ccgttacgtg accgtgaagg accagtggca ctcccgtggt tccacctggc tgtaccgtga 22140 aacctgcaac ctgaactgca tggtcaccat caccaccgct cgttccaagt acccttacca 22200 cttcttcgct acctccaccg gcgacgtggt ggacatctcc cccttctaca acggtactaa 22260 ccgtaacgct tcctacttcg gcgagaacgc tgacaagttc ttcatcttcc ccaactacac 22320 catcgtgtcc gacttcggtc gtcccaactc cgctctggaa acccaccgtc tggtggcttt 22380 cttggagcgt gctgactccg tgatctcctg ggacatccag gacgagaaga acgtgacctg 22440 ccagctgacc ttctgggagg cttccgagcg taccatccgt tccgaggctg aggactccta 22500 ccacttctcc agcgctaaga tgaccgctac cttcctgtcc aagaaacaag aggtcaacat 22560 gtccgactcc gccctggact gcgtgcgtga cgaggctatc aacaagctgc agcagatctt 22620 caacacctcc tacaaccaga cctacgagaa gtacggaaac gtgtccgtgt tcgagactac 22680 cggtggcctg gtggtgttct ggcagggtat caagcagaag tccctggtcg agctggaacg 22740 tctggctaac cgttcctccc tgaacctgac ccacaaccgt accaagcgtt ccaccgacgg 22800 caacaacgct actcacctgt ccaacatgga atccgtgcac aacctggtgt acgctcagct 22860 gcagttcacc tacgacaccc tgcgcggtta catcaaccgt gctctggctc agatcgctga 22920 ggcttggtgc gtggaccagc gtcgtaccct ggaagtgttc aaggaactgt ccaagatcaa 22980 cccctccgct atcctgtccg ccatctacaa caagcctatc gctgctcgtt tcatgggcga 23040 cgtgctgggc ctggcttcct gcgtgaccat caaccagact tccgtgaagg tgctgcgtga 23100 catgaacgtg aaggaatccc ccggtcgttg ctactcccgt cccgtggtca tcttcaactt 23160 cgctaactcc tcctacgtgc agtacggcca gctgggcgag gacaacgaga tcctgctggg 23220 caaccaccgt accgaggaat gccagctgcc ctccctgaag atcttcatcg ctggcaactc 23280 cgcttacgaa tacgtggact acctgttcaa gcgcatgatc gacctgtcct ccatctctac 23340 cgtggactcc atgatcgctc tggacatcga ccccctggaa aacaccgact tccgtgtgct 23400 ggaactgtac tcccagaagg aactgcgttc catcaacgtg ttcgacctgg aagagatcat 23460 gcgcgagttc aactcctaca agcagcgtgt taagtacgtc gaggacaagg tggtggaccc 23520 cctgcccccc tacctgaagg gactggacga cctgatgtcc ggcctgggag ctgccggcaa 23580 ggctgtgggt gtcgctatcg gtgctgtggg tggtgctgtg gcttccgtgg tcgagggtgt 23640 cgccaccttc ctgaagaacc ccttcggtgc tttcaccatc atcctggtgg ctatcgctgt 23700 ggtcatcatc atctacctga tctacacccg tcagcgtcgt ctgtgcatgc agcccctgca 23760 gaacctgttc ccctacctgg tgtccgctga cggtactacc gtgacctccg gcaacaccaa 23820 ggacacctcc ctgcaggctc ccccatccta cgaggaatcc gtctacaact ccggtcgcaa 23880 gggtcccggt cccccttcct ccgacgcttc taccgctgct cccccataca ccaacgagca 23940 ggcttaccag atgctgctgg ctctcgtgcg tctggacgct gagcagcgtg cacagcagaa 24000 cggcaccgac tccctggacg gccagaccgg aacccaggac aagggccaga agcccaacct 24060 gctggaccgt ctgcgtcacc gcaagaacgg ttaccgtcac ctgaaggact ccgacgagga 24120 agagaacgtc taaggcgcgc caagcttgtc gagaagtact agagatcata atcagccata 24180 ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga 24240 aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca 24300 aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt 24360 gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc 24420 ctagaagatc cggctgctaa caaagcccga aaggaagctg ggaatattaa tagatcatgg 24480 agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag 24540 ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg 24600 cggatccgcc accatgcgtc ccggcctgcc ctcctacctg atcgtgctgg ctgtgtgcct 24660 gctgtcccac ctcctgtcct cccgttacgg tgctgaggct atctccgagc ccctggacaa 24720 ggctttccac ctcctgctga acacctacgg tcgtcctatc cgtttcctgc gcgagaacac 24780 cacccagtgc acctacaact cctccctgcg caactccacc gtcgtccgcg agaacgctat 24840 ctccttcaac ttcttccagt cctacaacca gtactacgtg ttccacatgc cccgttgcct 24900 gttcgctggt cccctggctg agcagttcct gaaccaggtg gacctgaccg agactctcga 24960 gcgttaccag cagcgtctga acacttacgc tctggtgtcc aaggacctgg cttcctaccg 25020 ttccttcagc cagcagctga aggctcagga ctccctgggc gagcagccca ccactgtgcc 25080 tccccctatc gacctgtcca tcccccacgt gtggatgccc ccccagacca ctcctcacgg 25140 ctggaccgag tcccacacca cctccggact gcaccgtccc cacttcaacc agacctgcat 25200 cctgttcgac ggtcacgacc tgctgttctc caccgtgacc ccctgcctgc accagggctt 25260 ctacctcatc gacgagctgc gttacgtgaa gatcaccctg accgaggatt tcttcgtggt 25320 caccgtgtcc atcgacgacg acacccccat gctgctgatc ttcggtcacc tcccccgtgt 25380 gctgttcaag gctccctacc agcgtgacaa cttcatcctg cgtcagaccg agaagcacga 25440 gctgctggtg ctggtcaaga aggaccagct gaaccgtcac tcttacctga aggaccccga 25500 cttcctggac gctgctctgg acttcaacta cctggacctg tccgctctgc tgaggaactc 25560 cttccaccgt tacgctgtgg acgtgctgaa gtccggtcgt tgccagatgc tggaccgtcg 25620 taccgtcgag atggctttcg cttacgccct ggctctgttc gctgctgctc gtcaagaaga 25680 ggctggcgct caggtgtccg tgccccgtgc tctggaccgt caggctgctc tgctgcagat 25740 ccaagagttc atgatcactt gcctgtccca gaccccccct cgtaccaccc tgctgctgta 25800 ccccaccgct gtggacctgg ctaagcgtgc tctgtggacc cccaaccaga tcaccgacat 25860 cacctccctc gtgcgtctgg tgtacatcct gtccaagcag aaccagcagc acctgatccc 25920 ccagtgggct ctgcgtcaga tcgctgactt cgctctgaag ctgcacaaga cccacctggc 25980 ttcattcctc agcgctttcg ctcgccaaga gctgtacctg atgggttccc tggtgcactc 26040 catgctggtg cacaccaccg agcgtcgcga gatcttcatc gtggaaaccg gcctgtgctc 26100 cctggccgag ctgtcccact tcacccagct gctggctcac ccccaccacg agtacctgtc 26160 cgacctgtac accccctgct cctcttccgg tcgtcgtgac cactccctgg aacgtctgac 26220 ccgtctgttc cccgacgcta ccgtgcctac caccgtgcct gctgctctgt ccatcctgtc 26280 taccatgcag ccctccaccc tggaaacctt ccccgacctg ttctgcctgc ctctgggcga 26340 gtccttctcc gctctgaccg tgtccgagca cgtgtcctac gtggtcacca accagtacct 26400 gatcaagggc atctcctacc ccgtgtccac caccgtcgtg ggccagtccc tgatcatcac 26460 ccagaccgac tcccagacca agtgcgagct gacccgtaac atgcacacca ctcactccat 26520 caccgctgct ctgaacatct ccctcgagaa ctgcgctttc tgccagtccg ctctgttgga 26580 gtacgacgac actcagggtg tcatcaacat catgtacatg cacgactccg acgacgtgct 26640 gttcgctctg gacccctaca acgaggtggt ggtgtcctcc ccccgtaccc actacctgat 26700 gctgctgaag aacggcaccg tgctggaagt gaccgacgtg gtggtggacg ctaccgaccg 26760 tctgctgatg atgtccgtgt acgctctgtc cgctatcatc ggcatctacc tgctgtaccg 26820 tatgctgaag acctgctaag gcgccaagct ttgtcgagaa gtactagagg atcataatca 26880 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 26940 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 27000 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 27060 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 27120 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc 27180 accgctgagc aataactatc ataaccccta ggagatccga accagataag tgaaatctag 27240 ttccaaacta ttttgtcatt tttaattttc gtattagctt acgacgctac acccagttcc 27300 catctatttt gtcactcttc cctaaataat ccttaaaaac tccatttcca cccctcccag 27360 ttcccaacta ttttgtccgc ccaca 27385 <210> 52 <211> 18550 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 52 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttactgcagc caccaccaca gggagttcag ggtggacagg 2400 ttcacagcac gacggtgctc agggggggtc aggttgccgt aggtggagga ctgcaggctg 2460 aagttacgga tctcagacag gaacagcagg gagtccaggt agtcccacat ggggtcgatg 2520 aaggtgcgct ggaaacgggt ggatggggag gtgggggtgg tcttgttgtt gtcggaagca 2580 gtctcgttct cgacgggcat ggtgtcgttg tagtacaggg aggacatgtc cagggtgccg 2640 tagatggtgt agggagtctc gttacggatc agcacgtgag tgttcttcat gaactcggac 2700 acagcggtac ggttacggtt gggcttgcag aagggctcgt cacggtaacg cagggtggtg 2760 tacacccagg tagccaggtc cttcagctga gtggtcagga tagacttcat gaagttctcg 2820 tcgggacggt aaccgatggt agaggtgggg atacgggtgg gcacgatggg ggagtaggtc 2880 acgttggtgg aaacgttgaa gatggtggag gtgtaggagg agtagggggt agtagtgctg 2940 acgcgggact tcttggagat ggacttcacg ggagcctgct tgcgcttcag cttgcgcatg 3000 gtgttcttca gcttggtgga gttgatgtac ttgggcacac ggaagatgtt acgggacata 3060 gcgttgacca ggtagaagga acgggtgcag ttgcgctgag cgtaacgcag cagcagagca 3120 gccaggccca ggaagtagat agtctgggag tccacgttga ccttggaggg gcccacgtac 3180 agcttggtgt tccaacgggg cacgttgaag aacatggggt tgaaggtggt gaagttgccg 3240 cagttttcct cgccggtgtt gttacgacgg gacacgttca gcatctcgga caggcaggtc 3300 atggagggga tggtgccgca agagggggga cggaaggtga tcttctggcc ggtgtggttg 3360 tactcggagt acacgtactt agcgggcttg cgcagctggg tggtgtggaa gtcgaaccac 3420 aggtgggtga tggagtggtt acggatggga ccagccagga tggagttggg ggggaactgc 3480 ttcatctcga cggtgatgtt gtacagcttc tgctggctgg ggaaggtgaa gaacttgtag 3540 tagtcgccgg tcttggaagc cagctcttgc aggatacgca gcttcagctg gcgttcctct 3600 tccttagcct tctgggactt cacacggaaa cgagccacag cgatcttgca gttgatgaag 3660 ctgaacagca ggaaggtcag ggacatcagg aagaacaggt tgaacacgcc acgcatctcg 3720 cccttgcgac ccatggtggc ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 3780 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 3840 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 3900 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 3960 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 4020 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat ggaaaactgg 4080 tccgctctgg aactgctgcc caaggtcgga atccctaccg acttcctgac ccacgtcaag 4140 acctccgctg gcgaggaaat gttcgaggct ctgaggatct actacggcga cgaccccgag 4200 cgttacaaca tccacttcga ggctatcttc ggcaccttct gcaaccgtct ggaatgggtg 4260 tacttcctga cttccggcct ggctgctgct gctcacgcta tcaagttcca cgacctgaac 4320 aagctgacca ccggcaagat gctgttccac gtgcaagtgc cccgtgtggc ttccggtgct 4380 ggcctgccta cctcccgtca gaccaccatc atggtcacca agtactccga gaagtccccc 4440 atcaccatcc ctttcgagct gtccgctgct tgcctgactt acctgcgtga aaccttcgag 4500 ggcaccatcc tggacaagat cctgaacgtc gaggctatgc acaccgtgct gcgtgctctg 4560 aagaacaccg ctgacgctat ggaacgtggc ctgatccaca gcttcctcca gaccctgctg 4620 aggaaggctc ccccctactt cgtggtgcag accctggtcg agaacgctac cctggctcgt 4680 caggctctga accgtatcca gcgctccaac atcctgcagt ccttcaaggc taagatgctg 4740 gctaccctgt tcctgctgaa ccgtacccgt gaccgtgact acgtgctgaa gttcctgacc 4800 cgtctggctg aggctgctac cgactccatc ctcgacaacc ctactaccta caccacctcc 4860 tccggtgcta agatctccgg tgtcatggtg tccaccgcta acgtgatgca gatcatcatg 4920 tccctgctgt cctcccacat cactaaggaa accgtgtccg ctcccgctac ctacggcaac 4980 ttcgtgctgt cccccgagaa cgctgtgacc gctatctcct accactctat cctggctgac 5040 ttcaactcct acaaggctca cctgacctcc ggccagcccc acctccccaa cgactccctg 5100 agccaggctg gtgctcactc cctgaccccc ctgtccatgg acgtgatccg tctgggcgaa 5160 aagaccgtga tcatggaaaa cctgcgtcgc gtgtacaaga acaccgacac caaggacccc 5220 ctggaacgta acgtggacct gaccttcttc ttccccgtgg gcctgtacct gcccgaggac 5280 cgtggttaca ccaccgtcga gtccaaggtc aagctgaacg acaccgtgcg taacgctctg 5340 cccaccaccg cttacctgct gaacagggac cgtgctgtgc aaaagatcga cttcgtggac 5400 gctctcaaga ccctgtgcca ccccgtgctg cacgagcctg ctccatgcct gcaggctttc 5460 accgagcgtg gtcccccatc cgagcccgct atgcagcgtc tgctggaatg ccgtttccag 5520 caagagccca tgggtggtgc tgctcgtcgt atcccccact tctaccgtgt gcgccgcgag 5580 gtgccccgta ccgtgaacga gatgaagcag gacttcgtgg tcaccgactt ctacaaggtt 5640 ggaaacatca ccctgtacac cgagctgcac cctttcttcg acttcaccca ctgccaagag 5700 aactccgaga ctgtggctct gtgcaccccc cgtatcgtga tcggcaacct gcccgacggc 5760 ctggctcccg gtcccttcca cgagctgagg acctgggaga tcatggaaca catgcgcctg 5820 cgtcccccac ccgactacga ggaaaccctg cgtctgttca agaccaccgt gacctccccc 5880 aactaccccg agctgtgcta cctggtggac gtgctggtgc acggcaacgc tgacgctttc 5940 ctgctgatcc gcgctttcat cgctcgttgc atcgtgaaca tgttccacac ccgtcagctg 6000 ctggtgttcg ctcactccta cgctctggtc accctgatcg ctgagcacct ggctgacggt 6060 gctctgcccc cccagctcct gttccactac cgtaacctgg tggctgtgct gcgcctggtc 6120 acccgtatct ccgctctgcc cggcctgaac aacggccagc tggctgagga acccctgtcc 6180 gcttacgtga acgctctgca cgaccacagg ctgtggcccc ccttcgtgac ccacctccct 6240 cgtaacatgg aaggtgtcca ggtggtggct gatcgtcagc ccctgaaccc cgctaacatc 6300 gaggctcgtc accacggtgt ctccgacgtg ccccgtctgg gtgctatgga cgctgacgag 6360 cccctgttcg tggacgacta ccgtgctacc gacgacgagt ggaccctgca aaaggtgttc 6420 tacctgtgcc tgatccccgc tatgaccaac aaccgtgctt gcggcctggg cctgaacctc 6480 aagactctgc tggtggacct gttctaccgt cccgccttcc tgctcatgcc cgctgctacc 6540 gctgtgtcca cctccggcac cacctccaag gaatccacct ctggtgtcac ccccgaggac 6600 tccgtggctg ctcagcgtca ggctgtgggc gagatgctga ccgagctggt cgaggacgtg 6660 gccaccgacg ctcacacccc tctgctgcag gcttgccgcg agctgttcct ggctgtgcag 6720 ttcgtgggcg agcacgtgaa ggtgctggaa gtgcgtgctc ccctggacca cgctcagagg 6780 cagggactgc ccgacttcat ctcccgtcag catgtgctgt acaacggttg ctgcgtcgtg 6840 accgctccta agaccctgat cgagtactcc ctgcccgtgc ccttccaccg tttctactcc 6900 aaccccacca tctgcgctgc tctgtccgac gacatcaagc gttacgtgac cgagttcccc 6960 cactaccata gacacgatgg tggtttcccc ctgcccaccg ctttcgctca cgagtaccac 7020 aactggctgc gtagcccctt ctcccgttac tccgctacct gccccaacgt gctgcactcc 7080 gtgatgaccc tggctgctat gctgtacaag atctcccccg tgtccctggt gctgcagacc 7140 aaggctcaca tccaccccgg tttcgctctg accgctgtgc gtaccgacac cttcgaggtg 7200 gacatgctgc tgtactccgg caagtcctgc acctccgtca tcatcaacaa ccccatcgtg 7260 accaaggaag agagggacat ctccaccacc taccacgtga cccagaacat caacaccgtg 7320 gacatgggcc tgggttacac ctccaacact tgcgtggcct acgtgaaccg cgtccgcacc 7380 gacatgggtg tccgtgtgca ggacctgttc cgtgtgttcc ccatgaacgt gtaccgccac 7440 gatgaggtgg accgttggat caggcacgct gctggcgtcg agcgtcccca gctgctggac 7500 accgagacta tctccatgct gaccttcggt tccatgtccg agcgcaacgc tgctgctacc 7560 gtgcacggcc agaaggctgt ctgcgagctg atcctgaccc ctgtgactat ggacgtgaac 7620 tacttcaaga tcaccaacaa ccctcgtggt cgtgcttcct gcatgctggg cgtggacccc 7680 tacgacaccg aggctgccac caaggctatc tacgaccacc gcgaggctga cgctcagacc 7740 ttcgctgcta cccacaaccc atgggcttcc caggctggtt gcctgtccga cgtcctgtac 7800 aacacccgtc accgcgagcg tctgggctac aactccaagt tctactcccc ctgcgctcag 7860 tacttcaaca ccgaggaaat catcgctgcc aacaagaccc tcttcaagac catcgacgag 7920 tacctgctgc gcgctaagga ctgcatccgt ggcgacaccg acactcagta cgtgtgcgtc 7980 gagggaaccg agcagctgat cgagaaccct tgccgtctga cccaagaggc tctgcccatc 8040 ctgtccacca ccaccctggc tctgatggaa actaagctga agggtggcgc tggtgctttc 8100 gctacctccg agactcactt cggcaactac gtcgtgggag agatcatccc cctgcagcag 8160 tccatgctgt tcaacagcta agagctcaag cttgtcgaga agtactagag gatcataatc 8220 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 8280 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 8340 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 8400 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 8460 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgc 8520 ccaccgctga gcaataacta tcataacccc cggaatatta atagatcatg gagataatta 8580 aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca gttttgtaat 8640 aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc gcggatccgc 8700 caccatggct gctatggaag ctaacatctt ctgcaccttc gaccacaagc tgtctatcgc 8760 tgacgtgggc aagctgacca agctggtggc tgctgtggtg cccatccccc agcgtctgca 8820 cctgatcaag cactaccagc tgggcctgca ccagttcgtg gaccacaccc gtggttacgt 8880 gcgtctgcgt ggcctgctgc gtaacatgac cctgaccctg atgcgtcgtg tcgagggcaa 8940 ccagatcctg ctgcacgtgc ccacccacgg cctgctgtac accgtgctga acaccggtcc 9000 cgtgacctgg gagaagggcg acgctctgtg cgtgctgccc cccctgttcc acggtcccct 9060 ggctcgtgaa aacctgttga ccctgggcca gtgggagctg gtgctgccct ggatcgtgcc 9120 catgcccctg gctctggaaa tcaaccagcg cctgctgatc atgggcctgt tctccctgga 9180 ccgttcctac gaagaagtga aggctgctgt ccagcagctg cagaccatca ccttccgtga 9240 cgctaccttc accatccccg accccgtgat cgaccagcac ctcctgatcg acatgaagac 9300 cgcttgcctg tccatgtcca tggtggctaa cctggcttcc gagctgacca tgacctacgt 9360 ccgcaagctg gctttggagg actcttccat gctgctggtc aagtgccaag agctgctgat 9420 gcgtctggac cgcgagcgtt ccgtgggcga gcctcgtact cccgctcgtc ctcagcacgt 9480 gtcccccgac gacgagatcg ctcgtctgtc cgctctgttc gtgatgctgc gtcagctgga 9540 cgacctgatc cgcgagcagg tcgtgttcac cgtgtgcgac gtgagcccag acaacaagtc 9600 cgctacctgc atcttcaagg gctaaggcgc gccaagcttg tcgagaagta ctagaggatc 9660 ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc 9720 cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct 9780 tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 9840 ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga 9900 tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc 9960 tgctgccacc gctgagcaat aactatcata acccccggaa tattaataga tcatggagat 10020 aattaaaatg ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt 10080 gtaataaaaa aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga 10140 tcccggtccg aagcgcgcgg aattcaaagg cctgccacca tggaaatgaa caaggtgctg 10200 catcaggatc tggtgcaggc tacccgtcgt atcctgaagc tgggcccctc cgagctgcgt 10260 gtgaccgacg ctggcctgat ctgcaagaac cccaactact ccgtgtgcga cgctatgctc 10320 aagaccgaca ccgtgtactg cgtcgagtac ctgctgtcct actgggagtc ccgtaccgac 10380 cacgtgccct gcttcatctt caagaacacc ggttgcgctg tgtccctgtg ctgcttcgtg 10440 cgtgctcccg tgaagctggt gtcccctgct cgtcacgtgg gcgagttcaa cgtgctgaag 10500 gtcaacgagt ccctgatcgt gaccctgaag gacatcgagg aaatcaagcc ctccgcttac 10560 ggtgtcctga ctaagtgcgt cgtccgcaag tccaactccg cttccgtgtt caacatcgag 10620 ctgatcgctt tcggtcccga gaacgagggc gagtacgaga acctgctgcg cgagctgtac 10680 gctaagaagg ctgcttccac ctccctggct gtgcgtaacc acgtgaccgt gtcctcccac 10740 tccggttccg gtccctccct gtggcgtgct cgtatgtccg ctgctctgac ccgtaccgct 10800 ggcaagcgct cctccaggac tgctagccct ccaccaccac ctcctcgtca ccctagctgc 10860 tctcccacta tggtggctgc tggtggagct gctgctggtc ctagacctcc ccctcctcct 10920 atggctgctg gatcctggcg tctgtgccgt tgcgaggctt gcatgggccg ttgcggttgc 10980 gcttccgagg gcgacgctga cgaggaagag gaagagttgc tggctctggc tggcgagggc 11040 aaggctgctg ctgccgctgc cggtcaagac gtcggtggtt ccgctcgtcg tcccctcgag 11100 gaacacgtgt cccgtcgtcg tggtgtctcc acccaccacc gtcacccccc ttccccacct 11160 tgcgctccct ccctggaacg taccggttac cgttgggctc cttcctcctg gtggcgcgct 11220 cgttctggtc cttcccgtcc ccagtccggt ccctggctgc ctgctcgttt cgctaccctg 11280 ggtcccctgg tcctggctct gctgttggtg ctggccctgc tgtggcgtgg tcacggtcaa 11340 tcccccagcc ccacccgttc cgctcaccgt gactaaaagc ttgtcgagaa gtactagagg 11400 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 11460 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 11520 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 11580 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 11640 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 11700 ggctgctgtg gctagctttg tttaacttta agaaggagat acatctagaa atattaatag 11760 atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc 11820 gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca 11880 tcgggcgcgg atcccggtcc gaagcgcgcg gaattcaaag gcctacgtcg acgccaccat 11940 gtccaacacc gctcccggtc ccaccgtggc taacaagcgt gacgagaagc accgtcacgt 12000 ggtcaacgtg gtgctcgagc tgcccaccga gatctccgag gctacccacc ccgtgctggc 12060 taccatgctg tccaagtaca cccgtatgtc ctccctgttc aacgacaagt gcgctttcaa 12120 gctggacctg ctgcgtatgg tggctgtgtc ccgtacccgt cgctaaaagc ttgtcgagaa 12180 gtactagagg atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa 12240 cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt 12300 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 12360 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 12420 tgtctggatc tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg 12480 aagctgagtt ggctgctggg tgcctaatga gtgagctaac tcacattaat tgcccggaat 12540 attaatagat catggagata attaaaatga taaccatctc gcaaataaat aagtatttta 12600 ctgttttcgt aacagttttg taataaaaaa acctataaat attccggatt attcataccg 12660 tcccaccatc gggcgcggat cccggtccga agcgcgcgga attcgccacc atggacgctc 12720 gtgctgtggc taagcgtccc cgtgaccccg ctgacgagga caacgagctg gtcaccgctc 12780 tgaaggctaa gcgtgaagtg aacaccatct ccgtgcgtta cctgtaccac gctgaccacc 12840 aggctctgac cgctcgtttc ttcgtgcccg agggcctggt cgagttcgag gctcagcccg 12900 gtgctctgct gatccgtatg gaaaccggtt gcgactcccc ccgtcacctg tacatctccc 12960 tgtacctgct gggtatccgt gcttccaacg tgtccgcttc cacccgttgc ctgctcgagt 13020 ccgtgtacac cgcttccgct gctcgtgctg ctctgcagtg gctggacctg ggtccccacc 13080 tcctgcaccg tcgtctggaa accctgggtt gcgtcaagac cgtgtccctg ggtatcacct 13140 ccctgctgac ctgcgtgatg cgcggctacc tgtacaacac cctcaagacc gaggtgttcg 13200 ctctgatgat ccccaaggac atgtacctga cctgggagga aacccgcggt cgtctgcagt 13260 acgtgtacct gatcatcgtg tacgactacg acggtcccga gactcgtccc ggtatctacg 13320 tgctgacctc ctctatcgct cactggcaga ccctggtgga cgtggcccgt ggaaagttcg 13380 ctcgtgaacg ctgctccttc gtgaaccgtc gtatcacccg tccccgtcag atccccctgt 13440 gcaccggtgt catccaaaag ctgggctggt gcctggctga cgacatccac acctcattcc 13500 tcgtgcacaa ggaactgaag ctgtccgtcg tgcgtctgga caacttctcc gtcgagctgg 13560 gcgacttccg cgagttcgtg cagctgttga attttgacct tcttaagctt gcgggagacg 13620 tcgagtccaa ccctgggccc atggaatccc gtggtcgtcg ttgccccgag atgatctccg 13680 tgctgggtcc catctccggt cacgtcctga aggctgtgtt ctcccgtggc gacacccccg 13740 tgctgcccca cgaaactcgt ctgctgcaga ccggtatcca cgtgcgtgtg tcccagccct 13800 ccctgatcct ggtgtcccag tacacccccg actccacccc ttgccaccgc ggagacaacc 13860 agctgcaggt ccagcacacc tacttcaccg gttccgaggt cgagaacgtg tccgtgaacg 13920 tgcacaaccc caccggtcgt tccatctgcc cctcccaaga gcccatgtcc atctacgtgt 13980 acgctctgcc cctgaagatg ctgaacatcc cctccatcaa cgtgcaccac tacccctccg 14040 ctgctgagcg caagcaccgt cacctccccg tggctgacgc tgtgatccac gcttccggca 14100 agcagatgtg gcaggctcgt ctgaccgtgt ccggcctggc ttggacccgt cagcagaacc 14160 agtggaagga acccgacgtg tactacacct ccgctttcgt gttccccacc aaggacgtgg 14220 ccctgcgtca cgtcgtgtgc gctcacgaac tcgtgtgctc catggaaaac acccgtgcta 14280 ccaagatgca agtgatcggc gaccagtacg tgaaggtgta cctggaatcc ttctgcgagg 14340 acgtgccctc cggcaagctg ttcatgcacg tgaccctggg ttccgacgtg gaagaggacc 14400 tgaccatgac ccgtaacccc cagcccttca tgcgtcccca cgagcgtaac ggtttcaccg 14460 tgctgtgccc caagaacatg atcatcaagc ccggcaagat ctcccacatc atgctggacg 14520 tggccttcac ctcccacgag cacttcggcc tgctgtgccc taagtccatc cccggcctgt 14580 ccatctccgg caacctgctg atgaacggcc agcagatctt cctggaagtg caggctatcc 14640 gtgaaaccgt cgagctgcgt cagtacgacc ctgtggctgc tctgttcttc ttcgacatcg 14700 acctgctgct gcagcgtggt ccccagtact ccgagcaccc caccttcacc agccagtacc 14760 gtatccaggg caagctggaa taccgtcaca cctgggaccg tcacgacgag ggtgctgctc 14820 agggcgacga cgacgtgtgg acctccggtt ccgactccga cgaggaactg gtcaccaccg 14880 agcgcaagac cccccgtgtg accggtggtg gtgctatggc tggtgcttcc acctccgctg 14940 gtcgcaagcg caagtccgct tcctccgcta ccgcttgcac cgctggtgtc atgacccgtg 15000 gtcgcctgaa ggctgagtcc accgtggctc ccgaagagga cactgacgag gactccgaca 15060 acgagatcca caaccccgct gtgttcacct ggcccccctg gcaggctggt atcctggctc 15120 gtaacctggt gcccatggtg gctaccgtgc agggccagaa cctgaagtac caagagttct 15180 tctgggacgc caacgacatc taccgtatct tcgctgagct ggaaggcgtg tggcagcccg 15240 ctgctcagcc caagcgtcgt cgtcaccgtc aggacgctct gcctggtccc tgtatcgctt 15300 ccacccccaa gaagcaccgc ggctaaaagc ttgtcgagaa gtactagagg atcataatca 15360 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 15420 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 15480 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 15540 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 15600 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgtg 15660 gctagctttg tttaacttta agaaggagat acatctagac ctgcaggccg gaatattaat 15720 agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt 15780 tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac 15840 catcgggcgc ggatcccggt ccgaagcgcg cggaattcgc caccatgacc atggacgagc 15900 agcagcccca ggctgtgacc cccgtgtacg tgggcggttt cctggctcgt tacgaccagt 15960 cccccgacga ggctgagctg ctgctgccac gtgacgtggt cgaacactgg ctgcacgctc 16020 agggccaggg acagccttcc ctgtccgtgg ctctgcccct gaacatcaac cacgacgaca 16080 ccgctgtcgt gggtcacgtg gccgctatgc agtccgtgcg tgacggcctg ttctgcctgg 16140 gttgcgtgac ctccccccgt ttcctggaaa tcgtgcgtcg tgcttccgag aagtccgagc 16200 tggtgtcccg tggtcccgtg tccccactgc agcccgacaa ggtggtcgag ttcctgtccg 16260 gttcctacgc tggcctgtcc ctgtcatccc gtcgttgcga cgacgtcgag gctgctacct 16320 ccctgagcgg ctccgagact acccccttca agcacgtggc cctgtgctcc gtgggtcgta 16380 ggcgtggaac cctggctgtg tacggtcgtg accccgagtg ggtcacccag cgtttccccg 16440 acctgaccgc tgctgaccgt gacggactgc gtgctcagtg gcagcgttgc ggttccaccg 16500 ctgtggacgc ttccggcgac cccttccgtt ccgactccta cggcctgctg ggcaactccg 16560 tggacgctct gtacatccgc gagcgtctgc ccaagctgcg ttacgacaag cagctcgtgg 16620 gtgtcaccga gcgcgagtcc tacgtgaagg cttccgtgtc ccccgaggct gcttgcgaca 16680 tcaaggctgc ttccgctgag cgttctggcg acagccgctc ccaggctgct actcctgctg 16740 ctggtgctcg tgtgccctcc agctccccat ccccacctgt cgagcctccc tcccccgtgc 16800 aacctcctgc tctgcctgct tccccctccg tgctgcctgc tgagtccagc ccctccctgt 16860 caccctctga gcctgctgag gctgcctcca tgtcccaccc tctgagcgct gctgtgactg 16920 ctgctaccgc tccccctggt gctactgtgg ctggtgcttc ccccgctgtg ccttccctgg 16980 cttggcctca cgacggtgtc tacctgccca aggacgcttt cttctccctg ctgggcgctt 17040 cccgttccgc tgctcccgtg atgtaccccg gtgctgtggc tgctcccccc agcgcttcac 17100 ctgctcctct gcccctgccc tcctaccccg cttcctacgg tgctcccgtc gtgggttacg 17160 accagctggc tgctcgtcac ttcgctgact acgtggaccc ccactacccc ggctggggtc 17220 gtcgttacga gcccgctcct tccctgcacc catcctaccc tgtgccccct cctccatcac 17280 ccgcttacta ccgtcgtcgt gactcccccg gtggcatgga cgagcctcca tctggatggg 17340 agcgttacga cggttcccac cgtggccagt cccaaaagca gcaccgtcac ggtggttccg 17400 gtggtcacaa caagcgtcgc aaggaagccg ctgctgcatc ctccagctcc gacgaggacc 17460 tgagcttccc cggcgaggct gaacacggtc gtgctcgcaa gcgtctgaag tcccacgtga 17520 actccgacgg aggtagcgga ggccacgctg gttccaacca gcagcagcaa cagcgctacg 17580 acgagctgcg tgacgctatc cacgagctga agcgtgacct gttcgctgct cgccagtcct 17640 ccaccctgct gtctgctgct ctgccagctg ccgcttcttc ctcccctacc accaccaccg 17700 tgtgcacccc tactggcgag ctgacctctg gtggtggcga gactcccacc gctctgctgt 17760 ccggtggtgc taaggtggcc gagcgtgctc aggctggtgt cgtgaacgct tcctgccgtc 17820 tggctaccgc ttccggttcc gaggctgcca ccgctggtcc ctctaccgct ggttcctcat 17880 cctgcccagc ttccgtggtg ctggctgccg ctgctgctca agccgccgct gcttcacagt 17940 cccccccaaa ggatatggtg gacctgaacc gtcgtatctt cgtggctgct ctgaacaagc 18000 tcgagtaata aaagcttgtc gagaagtact agaggatcat aatcagccat accacatttg 18060 tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa 18120 tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca 18180 atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt 18240 ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat 18300 ccggctgcta acaaagcccg aaaggaagct gagttggctg ctgccaccgc tgagcaataa 18360 ctatcataac ccctaggaga tccgaaccag ataagtgaaa tctagttcca aactattttg 18420 tcatttttaa ttttcgtatt agcttacgac gctacaccca gttcccatct attttgtcac 18480 tcttccctaa ataatcctta aaaactccat ttccacccct cccagttccc aactattttg 18540 tccgcccaca 18550 <210> 53 <211> 30872 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 53 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttac tgcagccacc accacaggga gttcagggtg gacaggttca 2400 cagcacgacg gtgctcaggg ggggtcaggt tgccgtaggt ggaggactgc aggctgaagt 2460 tacggatctc agacaggaac agcagggagt ccaggtagtc ccacatgggg tcgatgaagg 2520 tgcgctggaa acgggtggat ggggaggtgg gggtggtctt gttgttgtcg gaagcagtct 2580 cgttctcgac gggcatggtg tcgttgtagt acagggagga catgtccagg gtgccgtaga 2640 tggtgtaggg agtctcgtta cggatcagca cgtgagtgtt cttcatgaac tcggacacag 2700 cggtacggtt acggttgggc ttgcagaagg gctcgtcacg gtaacgcagg gtggtgtaca 2760 cccaggtagc caggtccttc agctgagtgg tcaggataga cttcatgaag ttctcgtcgg 2820 gacggtaacc gatggtagag gtggggatac gggtgggcac gatgggggag taggtcacgt 2880 tggtggaaac gttgaagatg gtggaggtgt aggaggagta gggggtagta gtgctgacgc 2940 gggacttctt ggagatggac ttcacgggag cctgcttgcg cttcagcttg cgcatggtgt 3000 tcttcagctt ggtggagttg atgtacttgg gcacacggaa gatgttacgg gacatagcgt 3060 tgaccaggta gaaggaacgg gtgcagttgc gctgagcgta acgcagcagc agagcagcca 3120 ggcccaggaa gtagatagtc tgggagtcca cgttgacctt ggaggggccc acgtacagct 3180 tggtgttcca acggggcacg ttgaagaaca tggggttgaa ggtggtgaag ttgccgcagt 3240 tttcctcgcc ggtgttgtta cgacgggaca cgttcagcat ctcggacagg caggtcatgg 3300 aggggatggt gccgcaagag gggggacgga aggtgatctt ctggccggtg tggttgtact 3360 cggagtacac gtacttagcg ggcttgcgca gctgggtggt gtggaagtcg aaccacaggt 3420 gggtgatgga gtggttacgg atgggaccag ccaggatgga gttggggggg aactgcttca 3480 tctcgacggt gatgttgtac agcttctgct ggctggggaa ggtgaagaac ttgtagtagt 3540 cgccggtctt ggaagccagc tcttgcagga tacgcagctt cagctggcgt tcctcttcct 3600 tagccttctg ggacttcaca cggaaacgag ccacagcgat cttgcagttg atgaagctga 3660 acagcaggaa ggtcagggac atcaggaaga acaggttgaa cacgccacgc atctcgccct 3720 tgcgacccat ggtggcctcg agatcccggg tgatcaagtc ttcgtcgagt gattgtaaat 3780 aaaatgtaat ttacagtata gtattttaat taatatacaa atgatttgat aataattctt 3840 atttaactat aatatattgt gttgggttga attaaaggtc cgtatactag tatcgattcg 3900 cgacctactc cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa 3960 ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc 4020 cggattattc ataccgtccc accatcgggc gcggatccgc caccatggaa aactggtccg 4080 ctctggaact gctgcccaag gtcggaatcc ctaccgactt cctgacccac gtcaagacct 4140 ccgctggcga ggaaatgttc gaggctctga ggatctacta cggcgacgac cccgagcgtt 4200 acaacatcca cttcgaggct atcttcggca ccttctgcaa ccgtctggaa tgggtgtact 4260 tcctgacttc cggcctggct gctgctgctc acgctatcaa gttccacgac ctgaacaagc 4320 tgaccaccgg caagatgctg ttccacgtgc aagtgccccg tgtggcttcc ggtgctggcc 4380 tgcctacctc ccgtcagacc accatcatgg tcaccaagta ctccgagaag tcccccatca 4440 ccatcccttt cgagctgtcc gctgcttgcc tgacttacct gcgtgaaacc ttcgagggca 4500 ccatcctgga caagatcctg aacgtcgagg ctatgcacac cgtgctgcgt gctctgaaga 4560 acaccgctga cgctatggaa cgtggcctga tccacagctt cctccagacc ctgctgagga 4620 aggctccccc ctacttcgtg gtgcagaccc tggtcgagaa cgctaccctg gctcgtcagg 4680 ctctgaaccg tatccagcgc tccaacatcc tgcagtcctt caaggctaag atgctggcta 4740 ccctgttcct gctgaaccgt acccgtgacc gtgactacgt gctgaagttc ctgacccgtc 4800 tggctgaggc tgctaccgac tccatcctcg acaaccctac tacctacacc acctcctccg 4860 gtgctaagat ctccggtgtc atggtgtcca ccgctaacgt gatgcagatc atcatgtccc 4920 tgctgtcctc ccacatcact aaggaaaccg tgtccgctcc cgctacctac ggcaacttcg 4980 tgctgtcccc cgagaacgct gtgaccgcta tctcctacca ctctatcctg gctgacttca 5040 actcctacaa ggctcacctg acctccggcc agccccacct ccccaacgac tccctgagcc 5100 aggctggtgc tcactccctg acccccctgt ccatggacgt gatccgtctg ggcgaaaaga 5160 ccgtgatcat ggaaaacctg cgtcgcgtgt acaagaacac cgacaccaag gaccccctgg 5220 aacgtaacgt ggacctgacc ttcttcttcc ccgtgggcct gtacctgccc gaggaccgtg 5280 gttacaccac cgtcgagtcc aaggtcaagc tgaacgacac cgtgcgtaac gctctgccca 5340 ccaccgctta cctgctgaac agggaccgtg ctgtgcaaaa gatcgacttc gtggacgctc 5400 tcaagaccct gtgccacccc gtgctgcacg agcctgctcc atgcctgcag gctttcaccg 5460 agcgtggtcc cccatccgag cccgctatgc agcgtctgct ggaatgccgt ttccagcaag 5520 agcccatggg tggtgctgct cgtcgtatcc cccacttcta ccgtgtgcgc cgcgaggtgc 5580 cccgtaccgt gaacgagatg aagcaggact tcgtggtcac cgacttctac aaggttggaa 5640 acatcaccct gtacaccgag ctgcaccctt tcttcgactt cacccactgc caagagaact 5700 ccgagactgt ggctctgtgc accccccgta tcgtgatcgg caacctgccc gacggcctgg 5760 ctcccggtcc cttccacgag ctgaggacct gggagatcat ggaacacatg cgcctgcgtc 5820 ccccacccga ctacgaggaa accctgcgtc tgttcaagac caccgtgacc tcccccaact 5880 accccgagct gtgctacctg gtggacgtgc tggtgcacgg caacgctgac gctttcctgc 5940 tgatccgcgc tttcatcgct cgttgcatcg tgaacatgtt ccacacccgt cagctgctgg 6000 tgttcgctca ctcctacgct ctggtcaccc tgatcgctga gcacctggct gacggtgctc 6060 tgccccccca gctcctgttc cactaccgta acctggtggc tgtgctgcgc ctggtcaccc 6120 gtatctccgc tctgcccggc ctgaacaacg gccagctggc tgaggaaccc ctgtccgctt 6180 acgtgaacgc tctgcacgac cacaggctgt ggcccccctt cgtgacccac ctccctcgta 6240 acatggaagg tgtccaggtg gtggctgatc gtcagcccct gaaccccgct aacatcgagg 6300 ctcgtcacca cggtgtctcc gacgtgcccc gtctgggtgc tatggacgct gacgagcccc 6360 tgttcgtgga cgactaccgt gctaccgacg acgagtggac cctgcaaaag gtgttctacc 6420 tgtgcctgat ccccgctatg accaacaacc gtgcttgcgg cctgggcctg aacctcaaga 6480 ctctgctggt ggacctgttc taccgtcccg ccttcctgct catgcccgct gctaccgctg 6540 tgtccacctc cggcaccacc tccaaggaat ccacctctgg tgtcaccccc gaggactccg 6600 tggctgctca gcgtcaggct gtgggcgaga tgctgaccga gctggtcgag gacgtggcca 6660 ccgacgctca cacccctctg ctgcaggctt gccgcgagct gttcctggct gtgcagttcg 6720 tgggcgagca cgtgaaggtg ctggaagtgc gtgctcccct ggaccacgct cagaggcagg 6780 gactgcccga cttcatctcc cgtcagcatg tgctgtacaa cggttgctgc gtcgtgaccg 6840 ctcctaagac cctgatcgag tactccctgc ccgtgccctt ccaccgtttc tactccaacc 6900 ccaccatctg cgctgctctg tccgacgaca tcaagcgtta cgtgaccgag ttcccccact 6960 accatagaca cgatggtggt ttccccctgc ccaccgcttt cgctcacgag taccacaact 7020 ggctgcgtag ccccttctcc cgttactccg ctacctgccc caacgtgctg cactccgtga 7080 tgaccctggc tgctatgctg tacaagatct cccccgtgtc cctggtgctg cagaccaagg 7140 ctcacatcca ccccggtttc gctctgaccg ctgtgcgtac cgacaccttc gaggtggaca 7200 tgctgctgta ctccggcaag tcctgcacct ccgtcatcat caacaacccc atcgtgacca 7260 aggaagagag ggacatctcc accacctacc acgtgaccca gaacatcaac accgtggaca 7320 tgggcctggg ttacacctcc aacacttgcg tggcctacgt gaaccgcgtc cgcaccgaca 7380 tgggtgtccg tgtgcaggac ctgttccgtg tgttccccat gaacgtgtac cgccacgatg 7440 aggtggaccg ttggatcagg cacgctgctg gcgtcgagcg tccccagctg ctggacaccg 7500 agactatctc catgctgacc ttcggttcca tgtccgagcg caacgctgct gctaccgtgc 7560 acggccagaa ggctgtctgc gagctgatcc tgacccctgt gactatggac gtgaactact 7620 tcaagatcac caacaaccct cgtggtcgtg cttcctgcat gctgggcgtg gacccctacg 7680 acaccgaggc tgccaccaag gctatctacg accaccgcga ggctgacgct cagaccttcg 7740 ctgctaccca caacccatgg gcttcccagg ctggttgcct gtccgacgtc ctgtacaaca 7800 cccgtcaccg cgagcgtctg ggctacaact ccaagttcta ctccccctgc gctcagtact 7860 tcaacaccga ggaaatcatc gctgccaaca agaccctctt caagaccatc gacgagtacc 7920 tgctgcgcgc taaggactgc atccgtggcg acaccgacac tcagtacgtg tgcgtcgagg 7980 gaaccgagca gctgatcgag aacccttgcc gtctgaccca agaggctctg cccatcctgt 8040 ccaccaccac cctggctctg atggaaacta agctgaaggg tggcgctggt gctttcgcta 8100 cctccgagac tcacttcggc aactacgtcg tgggagagat catccccctg cagcagtcca 8160 tgctgttcaa cagctaagag ctcaagcttg tcgagaagta ctagaggatc ataatcagcc 8220 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 8280 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 8340 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 8400 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 8460 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgcccac 8520 cgctgagcaa taactatcat aacccccgga atattaatag atcatggaga taattaaaat 8580 gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt tgtaataaaa 8640 aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg atccgccacc 8700 atggctgcta tggaagctaa catcttctgc accttcgacc acaagctgtc tatcgctgac 8760 gtgggcaagc tgaccaagct ggtggctgct gtggtgccca tcccccagcg tctgcacctg 8820 atcaagcact accagctggg cctgcaccag ttcgtggacc acacccgtgg ttacgtgcgt 8880 ctgcgtggcc tgctgcgtaa catgaccctg accctgatgc gtcgtgtcga gggcaaccag 8940 atcctgctgc acgtgcccac ccacggcctg ctgtacaccg tgctgaacac cggtcccgtg 9000 acctgggaga agggcgacgc tctgtgcgtg ctgccccccc tgttccacgg tcccctggct 9060 cgtgaaaacc tgttgaccct gggccagtgg gagctggtgc tgccctggat cgtgcccatg 9120 cccctggctc tggaaatcaa ccagcgcctg ctgatcatgg gcctgttctc cctggaccgt 9180 tcctacgaag aagtgaaggc tgctgtccag cagctgcaga ccatcacctt ccgtgacgct 9240 accttcacca tccccgaccc cgtgatcgac cagcacctcc tgatcgacat gaagaccgct 9300 tgcctgtcca tgtccatggt ggctaacctg gcttccgagc tgaccatgac ctacgtccgc 9360 aagctggctt tggaggactc ttccatgctg ctggtcaagt gccaagagct gctgatgcgt 9420 ctggaccgcg agcgttccgt gggcgagcct cgtactcccg ctcgtcctca gcacgtgtcc 9480 cccgacgacg agatcgctcg tctgtccgct ctgttcgtga tgctgcgtca gctggacgac 9540 ctgatccgcg agcaggtcgt gttcaccgtg tgcgacgtga gcccagacaa caagtccgct 9600 acctgcatct tcaagggcta aggcgcgcca agcttgtcga gaagtactag aggatcataa 9660 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 9720 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 9780 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 9840 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 9900 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 9960 gccaccgctg agcaataact atcataaccc ccggaatatt aatagatcat ggagataatt 10020 aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa 10080 taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccc 10140 ggtccgaagc gcgcggaatt caaaggcctg ccaccatgga aatgaacaag gtgctgcatc 10200 aggatctggt gcaggctacc cgtcgtatcc tgaagctggg cccctccgag ctgcgtgtga 10260 ccgacgctgg cctgatctgc aagaacccca actactccgt gtgcgacgct atgctcaaga 10320 ccgacaccgt gtactgcgtc gagtacctgc tgtcctactg ggagtcccgt accgaccacg 10380 tgccctgctt catcttcaag aacaccggtt gcgctgtgtc cctgtgctgc ttcgtgcgtg 10440 ctcccgtgaa gctggtgtcc cctgctcgtc acgtgggcga gttcaacgtg ctgaaggtca 10500 acgagtccct gatcgtgacc ctgaaggaca tcgaggaaat caagccctcc gcttacggtg 10560 tcctgactaa gtgcgtcgtc cgcaagtcca actccgcttc cgtgttcaac atcgagctga 10620 tcgctttcgg tcccgagaac gagggcgagt acgagaacct gctgcgcgag ctgtacgcta 10680 agaaggctgc ttccacctcc ctggctgtgc gtaaccacgt gaccgtgtcc tcccactccg 10740 gttccggtcc ctccctgtgg cgtgctcgta tgtccgctgc tctgacccgt accgctggca 10800 agcgctcctc caggactgct agccctccac caccacctcc tcgtcaccct agctgctctc 10860 ccactatggt ggctgctggt ggagctgctg ctggtcctag acctccccct cctcctatgg 10920 ctgctggatc ctggcgtctg tgccgttgcg aggcttgcat gggccgttgc ggttgcgctt 10980 ccgagggcga cgctgacgag gaagaggaag agttgctggc tctggctggc gagggcaagg 11040 ctgctgctgc cgctgccggt caagacgtcg gtggttccgc tcgtcgtccc ctcgaggaac 11100 acgtgtcccg tcgtcgtggt gtctccaccc accaccgtca ccccccttcc ccaccttgcg 11160 ctccctccct ggaacgtacc ggttaccgtt gggctccttc ctcctggtgg cgcgctcgtt 11220 ctggtccttc ccgtccccag tccggtccct ggctgcctgc tcgtttcgct accctgggtc 11280 ccctggtcct ggctctgctg ttggtgctgg ccctgctgtg gcgtggtcac ggtcaatccc 11340 ccagccccac ccgttccgct caccgtgact aaaagcttgt cgagaagtac tagaggatca 11400 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 11460 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 11520 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 11580 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 11640 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 11700 gctgtggcta gctttgttta actttaagaa ggagatacat ctagaaatat taatagatca 11760 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 11820 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 11880 gcgcggatcc cggtccgaag cgcgcggaat tcaaaggcct acgtcgacgc caccatgtcc 11940 aacaccgctc ccggtcccac cgtggctaac aagcgtgacg agaagcaccg tcacgtggtc 12000 aacgtggtgc tcgagctgcc caccgagatc tccgaggcta cccaccccgt gctggctacc 12060 atgctgtcca agtacacccg tatgtcctcc ctgttcaacg acaagtgcgc tttcaagctg 12120 gacctgctgc gtatggtggc tgtgtcccgt acccgtcgct aaaagcttgt cgagaagtac 12180 tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc 12240 ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 12300 attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 12360 tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 12420 tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc 12480 tgagttggct gctgggtgcc taatgagtga gctaactcac attaattgcc cggaatatta 12540 atagatcatg gagataatta aaatgataac catctcgcaa ataaataagt attttactgt 12600 tttcgtaaca gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc 12660 accatcgggc gcggatcccg gtccgaagcg cgcggaattc gccaccatgg acgctcgtgc 12720 tgtggctaag cgtccccgtg accccgctga cgaggacaac gagctggtca ccgctctgaa 12780 ggctaagcgt gaagtgaaca ccatctccgt gcgttacctg taccacgctg accaccaggc 12840 tctgaccgct cgtttcttcg tgcccgaggg cctggtcgag ttcgaggctc agcccggtgc 12900 tctgctgatc cgtatggaaa ccggttgcga ctccccccgt cacctgtaca tctccctgta 12960 cctgctgggt atccgtgctt ccaacgtgtc cgcttccacc cgttgcctgc tcgagtccgt 13020 gtacaccgct tccgctgctc gtgctgctct gcagtggctg gacctgggtc cccacctcct 13080 gcaccgtcgt ctggaaaccc tgggttgcgt caagaccgtg tccctgggta tcacctccct 13140 gctgacctgc gtgatgcgcg gctacctgta caacaccctc aagaccgagg tgttcgctct 13200 gatgatcccc aaggacatgt acctgacctg ggaggaaacc cgcggtcgtc tgcagtacgt 13260 gtacctgatc atcgtgtacg actacgacgg tcccgagact cgtcccggta tctacgtgct 13320 gacctcctct atcgctcact ggcagaccct ggtggacgtg gcccgtggaa agttcgctcg 13380 tgaacgctgc tccttcgtga accgtcgtat cacccgtccc cgtcagatcc ccctgtgcac 13440 cggtgtcatc caaaagctgg gctggtgcct ggctgacgac atccacacct cattcctcgt 13500 gcacaaggaa ctgaagctgt ccgtcgtgcg tctggacaac ttctccgtcg agctgggcga 13560 cttccgcgag ttcgtgcagc tgttgaattt tgaccttctt aagcttgcgg gagacgtcga 13620 gtccaaccct gggcccatgg aatcccgtgg tcgtcgttgc cccgagatga tctccgtgct 13680 gggtcccatc tccggtcacg tcctgaaggc tgtgttctcc cgtggcgaca cccccgtgct 13740 gccccacgaa actcgtctgc tgcagaccgg tatccacgtg cgtgtgtccc agccctccct 13800 gatcctggtg tcccagtaca cccccgactc caccccttgc caccgcggag acaaccagct 13860 gcaggtccag cacacctact tcaccggttc cgaggtcgag aacgtgtccg tgaacgtgca 13920 caaccccacc ggtcgttcca tctgcccctc ccaagagccc atgtccatct acgtgtacgc 13980 tctgcccctg aagatgctga acatcccctc catcaacgtg caccactacc cctccgctgc 14040 tgagcgcaag caccgtcacc tccccgtggc tgacgctgtg atccacgctt ccggcaagca 14100 gatgtggcag gctcgtctga ccgtgtccgg cctggcttgg acccgtcagc agaaccagtg 14160 gaaggaaccc gacgtgtact acacctccgc tttcgtgttc cccaccaagg acgtggccct 14220 gcgtcacgtc gtgtgcgctc acgaactcgt gtgctccatg gaaaacaccc gtgctaccaa 14280 gatgcaagtg atcggcgacc agtacgtgaa ggtgtacctg gaatccttct gcgaggacgt 14340 gccctccggc aagctgttca tgcacgtgac cctgggttcc gacgtggaag aggacctgac 14400 catgacccgt aacccccagc ccttcatgcg tccccacgag cgtaacggtt tcaccgtgct 14460 gtgccccaag aacatgatca tcaagcccgg caagatctcc cacatcatgc tggacgtggc 14520 cttcacctcc cacgagcact tcggcctgct gtgccctaag tccatccccg gcctgtccat 14580 ctccggcaac ctgctgatga acggccagca gatcttcctg gaagtgcagg ctatccgtga 14640 aaccgtcgag ctgcgtcagt acgaccctgt ggctgctctg ttcttcttcg acatcgacct 14700 gctgctgcag cgtggtcccc agtactccga gcaccccacc ttcaccagcc agtaccgtat 14760 ccagggcaag ctggaatacc gtcacacctg ggaccgtcac gacgagggtg ctgctcaggg 14820 cgacgacgac gtgtggacct ccggttccga ctccgacgag gaactggtca ccaccgagcg 14880 caagaccccc cgtgtgaccg gtggtggtgc tatggctggt gcttccacct ccgctggtcg 14940 caagcgcaag tccgcttcct ccgctaccgc ttgcaccgct ggtgtcatga cccgtggtcg 15000 cctgaaggct gagtccaccg tggctcccga agaggacact gacgaggact ccgacaacga 15060 gatccacaac cccgctgtgt tcacctggcc cccctggcag gctggtatcc tggctcgtaa 15120 cctggtgccc atggtggcta ccgtgcaggg ccagaacctg aagtaccaag agttcttctg 15180 ggacgccaac gacatctacc gtatcttcgc tgagctggaa ggcgtgtggc agcccgctgc 15240 tcagcccaag cgtcgtcgtc accgtcagga cgctctgcct ggtccctgta tcgcttccac 15300 ccccaagaag caccgcggct aaaagcttgt cgagaagtac tagaggatca taatcagcca 15360 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 15420 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 15480 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 15540 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 15600 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 15660 gctttgttta actttaagaa ggagatacat ctagacctgc aggccggaat attaatagat 15720 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 15780 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 15840 gggcgcggat cccggtccga agcgcgcgga attcgccacc atgaccatgg acgagcagca 15900 gccccaggct gtgacccccg tgtacgtggg cggtttcctg gctcgttacg accagtcccc 15960 cgacgaggct gagctgctgc tgccacgtga cgtggtcgaa cactggctgc acgctcaggg 16020 ccagggacag ccttccctgt ccgtggctct gcccctgaac atcaaccacg acgacaccgc 16080 tgtcgtgggt cacgtggccg ctatgcagtc cgtgcgtgac ggcctgttct gcctgggttg 16140 cgtgacctcc ccccgtttcc tggaaatcgt gcgtcgtgct tccgagaagt ccgagctggt 16200 gtcccgtggt cccgtgtccc cactgcagcc cgacaaggtg gtcgagttcc tgtccggttc 16260 ctacgctggc ctgtccctgt catcccgtcg ttgcgacgac gtcgaggctg ctacctccct 16320 gagcggctcc gagactaccc ccttcaagca cgtggccctg tgctccgtgg gtcgtaggcg 16380 tggaaccctg gctgtgtacg gtcgtgaccc cgagtgggtc acccagcgtt tccccgacct 16440 gaccgctgct gaccgtgacg gactgcgtgc tcagtggcag cgttgcggtt ccaccgctgt 16500 ggacgcttcc ggcgacccct tccgttccga ctcctacggc ctgctgggca actccgtgga 16560 cgctctgtac atccgcgagc gtctgcccaa gctgcgttac gacaagcagc tcgtgggtgt 16620 caccgagcgc gagtcctacg tgaaggcttc cgtgtccccc gaggctgctt gcgacatcaa 16680 ggctgcttcc gctgagcgtt ctggcgacag ccgctcccag gctgctactc ctgctgctgg 16740 tgctcgtgtg ccctccagct ccccatcccc acctgtcgag cctccctccc ccgtgcaacc 16800 tcctgctctg cctgcttccc cctccgtgct gcctgctgag tccagcccct ccctgtcacc 16860 ctctgagcct gctgaggctg cctccatgtc ccaccctctg agcgctgctg tgactgctgc 16920 taccgctccc cctggtgcta ctgtggctgg tgcttccccc gctgtgcctt ccctggcttg 16980 gcctcacgac ggtgtctacc tgcccaagga cgctttcttc tccctgctgg gcgcttcccg 17040 ttccgctgct cccgtgatgt accccggtgc tgtggctgct ccccccagcg cttcacctgc 17100 tcctctgccc ctgccctcct accccgcttc ctacggtgct cccgtcgtgg gttacgacca 17160 gctggctgct cgtcacttcg ctgactacgt ggacccccac taccccggct ggggtcgtcg 17220 ttacgagccc gctccttccc tgcacccatc ctaccctgtg ccccctcctc catcacccgc 17280 ttactaccgt cgtcgtgact cccccggtgg catggacgag cctccatctg gatgggagcg 17340 ttacgacggt tcccaccgtg gccagtccca aaagcagcac cgtcacggtg gttccggtgg 17400 tcacaacaag cgtcgcaagg aagccgctgc tgcatcctcc agctccgacg aggacctgag 17460 cttccccggc gaggctgaac acggtcgtgc tcgcaagcgt ctgaagtccc acgtgaactc 17520 cgacggaggt agcggaggcc acgctggttc caaccagcag cagcaacagc gctacgacga 17580 gctgcgtgac gctatccacg agctgaagcg tgacctgttc gctgctcgcc agtcctccac 17640 cctgctgtct gctgctctgc cagctgccgc ttcttcctcc cctaccacca ccaccgtgtg 17700 cacccctact ggcgagctga cctctggtgg tggcgagact cccaccgctc tgctgtccgg 17760 tggtgctaag gtggccgagc gtgctcaggc tggtgtcgtg aacgcttcct gccgtctggc 17820 taccgcttcc ggttccgagg ctgccaccgc tggtccctct accgctggtt cctcatcctg 17880 cccagcttcc gtggtgctgg ctgccgctgc tgctcaagcc gccgctgctt cacagtcccc 17940 cccaaaggat atggtggacc tgaaccgtcg tatcttcgtg gctgctctga acaagctcga 18000 gtaataaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 18060 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 18120 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 18180 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 18240 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 18300 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 18360 cataacccct aggggcctct aaacgggtct tgaggggttt tttgctgaaa ggaggaacta 18420 tatccggatc tgaacaggag ggacagctga tagaaacaga agccactgga gcacctcaaa 18480 aacaccatca tacactaaat cagtaagttg gcagcatcac ccgacgcact ttgcgccgaa 18540 taaatacctg tgacggaaga tcacttcgca gaataaataa atcctggtgt ccctgttgat 18600 accgggaagc cctgggccaa cttttggcga aaatgagacg ttgatcggca cgtaagaggt 18660 tccaactttc accataatga aataagatca ctaccgggcg tattttttga gttatcgaga 18720 ttttcaggag ctaaggaagc taaaatggag aaaaaaatca ctggatatac caccgttgat 18780 atatcccaat ggcatcgtaa agaacatttt gaggcatttc agtcagttgc tcaatgtacc 18840 tataaccaga ccgttcagct ggatattacg gcctttttaa agaccgtaaa gaaaaataag 18900 cacaagtttt atccggcctt tattcacatt cttgcccgcc tgatgaatgc tcatccggaa 18960 ttccgtatgg caatgaaaga cggtgagctg gtgatatggg atagtgttca cccttgttac 19020 accgttttcc atgagcaaac tgaaacgttt tcatcgctct ggagtgaata ccacgacgat 19080 ttccggcagt ttctacacat atattcgcaa gatgtggcgt gttacggtga aaacctggcc 19140 tatttcccta aagggtttat tgagaatatg tttttcgtct cagccaatcc ctgggtgagt 19200 ttcaccagtt ttgatttaaa cgtggccaat atggacaact tcttcgcccc cgttttcacc 19260 atgggcaaat attatacgca aggcgacaag gtgctgatgc cgctggcgat tcaggttcat 19320 catgccgttt gtgatggctt ccatgtcggc agaatgctta atgaattaca acagtactgc 19380 gatgagtggc agggcggggc gtaatttttt taaggcagtt attggtgccc ttaaacgcct 19440 ggttgctacg cctgaataag tgataataag cggatgaatg gcagaaattc gaaagcaaat 19500 tcgacccggt cgtcggttca gggcagggtc gttaaatagc cgcttatgtc tattgctggt 19560 ttaccggttt attgactacc ggaagcagtg tgaccgtgtg cttctcaaat gcctgaggcc 19620 agtttgctca ggctctcccc gtggaggtaa taattgacga tatgatcatt tattctgcct 19680 cccagctgac attcatccgg ggtcagcacc gtttctgcgg actggctttc tacgtgttcc 19740 gcttccttta gcagcccttg cgccctgagt gcttgcggca gcgtgaagct aattctgtca 19800 gccgttaagt gttcctgtgt cactcaaaat tgctttgaga ggctctaagg gcttctcagt 19860 gcgttacatc cctggcttgt tgtccacaac cgttaaacct taaaagcttt aaaagcctta 19920 tatattcttt tttttcttat aaaacttaaa accttagagg ctatttaagt tgctgattta 19980 tattaatttt attgttcaaa catgagagct tagtacgtga aacatgagag cttagtacgt 20040 tagccatgag agcttagtac gttagccatg agggtttagt tcgttaaaca tgagagctta 20100 gtacgttaaa catgagagct tagtacgtga aacatgagag cttagtacgt actatcaaca 20160 ggttgaactg ctgatcaaca gatcctctac gcggccgcgg taccataact tcgtatagca 20220 tacattatac gaagttatct ggtttaaacg tacccgtagt ggctatggca gggcttgccg 20280 ccccgacgtt ggctgcgagc cctgggcctt cacccgaact tgggggttgg ggtggggaaa 20340 aggaagaaac gcgggcgtat tggtcccaat ggggtctcgg tggggtatcg acagagtgcc 20400 agccctggga ccgaaccccg cgtttatgaa caaacgaccc aacacccgtg cgttttattc 20460 tgtcttttta ttgccgtcat agcgcgggtt ccttccggta ttgtctcctt ccgtgtttca 20520 gttagcctcc cccatctccc ggtaccgcat gctatgcatc agctgctagc ttagcgagcg 20580 tccacagcct ggggaccgta acgggagtga gcgggcaggt tcacacgggt ctgcttcagc 20640 tcagggggca ggccagcgta gtacttgtcc aggtgacgca gcaggggggg gtccagctgg 20700 tgacgcaggc agaattcctt cacagcgttg tacaggccgt agaacagggt gataccctcg 20760 ggagcagcag cggtggacac gggcagacgc acagcacggt tggtacgggt agcctcgtta 20820 cggatagcca ccaccacgtt gaacagggag gggggcacca gctcgaaacc cagcacgtgt 20880 tcggtgaaga tggaacgacc gtaggacaga cgagtcaggt cgtaaccacg gcacaggtcg 20940 tccacgcaag tgtacacagc gggggaaccg tcgccgcact cggagtaacc gcgcatcacg 21000 gtcatccaac ggggagcggt gtcggaggac agcagggtca gcagagcacg cagctggtcg 21060 gggttgttgt acagcagggc cagggtgtcc aggaaagcgt cgtccagcag cacggagtta 21120 gcagcctcgg gggtcacggg acggtaacgg atcagctggg acaggggacc gtccctacgg 21180 gtcacgttga ccaggggacg cagccaggac tcgtacttgt cgccctggaa cacctctccc 21240 agcaggcaac gacgggtcag ctcggggcac tcagcgggca ccttctcagc cacggtggga 21300 gccacggaca cggtagcgga ggacacgatg ggcagcagca ggcagcacca cagcagagcc 21360 acgggaccgg gggagaagga gaaaccgcag tcgggacgac ggcacatggt ggctcgagat 21420 cccgggtgat caagtcttcg tcgagtgatt gtaaataaaa tgtaatttac agtatagtat 21480 tttaattaat atacaaatga tttgataata attcttattt aactataata tattgtgttg 21540 ggttgaatta aaggtccgta tactagtatc gattcgcgac ctactccgga atattaatag 21600 atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc 21660 gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca 21720 tcgggcgcgg atccgccacc atgtccccca agaacctgac ccccttcctg accgctctgt 21780 ggctgctgct gggccactcc cgtgtgcctc gtgtgcgtgc tgaggaatgc tgcgagttca 21840 tcaacgtgaa ccaccccccc gagcgctgct acgacttcaa gatgtgcaac cgtttcaccg 21900 tggctctgcg ttgccccgac ggcgaagtgt gctactcccc cgaaaagacc gctgagatcc 21960 gtggtatcgt gaccaccatg acccactccc tgacccgtca ggtggtgcac aacaagctga 22020 cctcttgcaa ctacaacccc ctgtacctcg aggctgacgg tcgtatccgt tgcggcaagg 22080 tcaacgacaa ggctcagtac ctgctgggtg ctgctggttc cgtgccctac cgttggatca 22140 acctcgagta cgacaagatc acccgtatcg tgggcctgga ccagtacctc gagtccgtga 22200 agaagcacaa gcgtctggac gtgtgccgtg ctaagatggg ttacatgctg cagtaaaagc 22260 ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag gttttacttg 22320 ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg 22380 ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt 22440 tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg 22500 tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc tgctaacaaa 22560 gcccgaaagg aagctgagtt ggctgctgtg gctagctttg tttaacttta agaaggagat 22620 acatctagac cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa 22680 ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc 22740 cggattattc ataccgtccc accatcgggc gcggatccgc caccatgctg cgtctgctgc 22800 tgcgtcacca cttccactgc ctgctgctgt gcgctgtgtg ggctaccccc tgcctggctt 22860 ccccttggtc caccctgacc gctaaccaga acccctcccc accctggtcc aagctgacct 22920 actccaagcc ccacgacgct gctaccttct actgcccctt cctgtaccca tccccccctc 22980 gttccccact gcagttctcc ggtttccagc gtgtgctgac cggtcccgag tgccgtaacg 23040 agactctgta cctgctgtac aaccgcgagg gccagaccct ggtcgagagg tcctccacct 23100 gggtcaagaa ggtcatctgg tacttgtccg gtcgtaacca gaccatcctg cagcgtatgc 23160 cccgtaccgc ttccaagccc tccgacggca acgtgcagat ctccgtcgag gacgctaaga 23220 tcttcggtgc tcacatggtg cccaagcaga ccaagctgct gcgtttcgtg gtcaacgacg 23280 gcacccgtta ccagatgtgc gtgatgaagc tcgagtcctg ggctcacgtg ttccgtgact 23340 actccgtgtc cttccaagtg cgcctgacct tcaccgaggc taacaaccag acctacacct 23400 tctgcaccca ccccaacctg atcgtgtaaa agcttgtcga gaagtactag aggatcataa 23460 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 23520 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 23580 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 23640 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 23700 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 23760 gggtgcctaa tgagtgagct aactcacatt aattgcccgg aatattaata gatcatggag 23820 ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt 23880 ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg 23940 gatccgccac catgcgtctg tgccgtgtgt ggctgtccgt gtgcctgtgc gctgtggtgc 24000 tgggccagtg ccagcgtgaa accgctgaga agaacgacta ctaccgtgtg ccccactact 24060 gggacgcttg ctcccgtgct ctgcccgacc agacccgtta caagtacgtc gagcagctgg 24120 tggacctgac cctgaactac cactacgacg cttcccacgg cctggacaac ttcgacgtgc 24180 tgaagcgtat caacgtgacc gaggtgtccc tgctgatctc cgacttccgt cgtcagaacc 24240 gtcgtggtgg caccaacaag cgtaccacct tcaacgctgc tggttccctg gctccccacg 24300 ctcgttccct cgagttctcc gtgcgtctgt tcgctaacta aaagcttgtc gagaagtact 24360 agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc 24420 cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta 24480 ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat 24540 ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct 24600 ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg aaaggaagct 24660 gagttggctg ctgccaccgc tgagcaataa ctatcataac ccccggaata ttaatagatc 24720 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 24780 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 24840 ggcgcggatc ccggtccgaa gcgcgcggaa ttcaaaggcc taccgtcgac gccaccatgg 24900 aatcccgtat ctggtgcctg gtcgtgtgcg tgaacctgtg catcgtgtgc ctgggtgctg 24960 ctgtgtcctc ctcctccacc cgtggcacct ccgctaccca ctcccaccac tcctcccaca 25020 ccacctccgc cgctcactcc cgttccggtt ccgtgtccca gcgtgtgacc tcctcccaga 25080 ccgtgtccca cggtgtcaac gagactatct acaacaccac cctgaagtac ggcgacgtcg 25140 tgggtgtcaa caccaccaag tacccctacc gtgtgtgctc catggctcag ggcaccgacc 25200 tgatccgttt cgagcgtaac atcgtgtgca cctccatgaa gcccatcaac gaggacctgg 25260 acgagggtat catggtggtg tacaagcgca acatcgtggc tcacaccttc aaggtccgcg 25320 tgtaccagaa ggtgctgacc ttccgtcgtt cctacgctta catccacacc acttacctgc 25380 tgggttccaa caccgagtac gtggcccctc ccatgtggga gatccaccac atcaactccc 25440 actcccagtg ctactcctct tactcccgtg tgatcgctgg caccgtgttc gtggcttacc 25500 accgtgactc ctacgagaac aagaccatgc agctgatgcc cgacgactac tccaacaccc 25560 actccacccg ttacgtgacc gtgaaggacc agtggcactc ccgtggttcc acctggctgt 25620 accgtgaaac ctgcaacctg aactgcatgg tcaccatcac caccgctcgt tccaagtacc 25680 cttaccactt cttcgctacc tccaccggcg acgtggtgga catctccccc ttctacaacg 25740 gtactaaccg taacgcttcc tacttcggcg agaacgctga caagttcttc atcttcccca 25800 actacaccat cgtgtccgac ttcggtcgtc ccaactccgc tctggaaacc caccgtctgg 25860 tggctttctt ggagcgtgct gactccgtga tctcctggga catccaggac gagaagaacg 25920 tgacctgcca gctgaccttc tgggaggctt ccgagcgtac catccgttcc gaggctgagg 25980 actcctacca cttctccagc gctaagatga ccgctacctt cctgtccaag aaacaagagg 26040 tcaacatgtc cgactccgcc ctggactgcg tgcgtgacga ggctatcaac aagctgcagc 26100 agatcttcaa cacctcctac aaccagacct acgagaagta cggaaacgtg tccgtgttcg 26160 agactaccgg tggcctggtg gtgttctggc agggtatcaa gcagaagtcc ctggtcgagc 26220 tggaacgtct ggctaaccgt tcctccctga acctgaccca caaccgtacc aagcgttcca 26280 ccgacggcaa caacgctact cacctgtcca acatggaatc cgtgcacaac ctggtgtacg 26340 ctcagctgca gttcacctac gacaccctgc gcggttacat caaccgtgct ctggctcaga 26400 tcgctgaggc ttggtgcgtg gaccagcgtc gtaccctgga agtgttcaag gaactgtcca 26460 agatcaaccc ctccgctatc ctgtccgcca tctacaacaa gcctatcgct gctcgtttca 26520 tgggcgacgt gctgggcctg gcttcctgcg tgaccatcaa ccagacttcc gtgaaggtgc 26580 tgcgtgacat gaacgtgaag gaatcccccg gtcgttgcta ctcccgtccc gtggtcatct 26640 tcaacttcgc taactcctcc tacgtgcagt acggccagct gggcgaggac aacgagatcc 26700 tgctgggcaa ccaccgtacc gaggaatgcc agctgccctc cctgaagatc ttcatcgctg 26760 gcaactccgc ttacgaatac gtggactacc tgttcaagcg catgatcgac ctgtcctcca 26820 tctctaccgt ggactccatg atcgctctgg acatcgaccc cctggaaaac accgacttcc 26880 gtgtgctgga actgtactcc cagaaggaac tgcgttccat caacgtgttc gacctggaag 26940 agatcatgcg cgagttcaac tcctacaagc agcgtgttaa gtacgtcgag gacaaggtgg 27000 tggaccccct gcccccctac ctgaagggac tggacgacct gatgtccggc ctgggagctg 27060 ccggcaaggc tgtgggtgtc gctatcggtg ctgtgggtgg tgctgtggct tccgtggtcg 27120 agggtgtcgc caccttcctg aagaacccct tcggtgcttt caccatcatc ctggtggcta 27180 tcgctgtggt catcatcatc tacctgatct acacccgtca gcgtcgtctg tgcatgcagc 27240 ccctgcagaa cctgttcccc tacctggtgt ccgctgacgg tactaccgtg acctccggca 27300 acaccaagga cacctccctg caggctcccc catcctacga ggaatccgtc tacaactccg 27360 gtcgcaaggg tcccggtccc ccttcctccg acgcttctac cgctgctccc ccatacacca 27420 acgagcaggc ttaccagatg ctgctggctc tcgtgcgtct ggacgctgag cagcgtgcac 27480 agcagaacgg caccgactcc ctggacggcc agaccggaac ccaggacaag ggccagaagc 27540 ccaacctgct ggaccgtctg cgtcaccgca agaacggtta ccgtcacctg aaggactccg 27600 acgaggaaga gaacgtctaa ggcgcgccaa gcttgtcgag aagtactaga gatcataatc 27660 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 27720 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 27780 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 27840 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 27900 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctggga atattaatag 27960 atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc 28020 gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca 28080 tcgggcgcgg atccgccacc atgcgtcccg gcctgccctc ctacctgatc gtgctggctg 28140 tgtgcctgct gtcccacctc ctgtcctccc gttacggtgc tgaggctatc tccgagcccc 28200 tggacaaggc tttccacctc ctgctgaaca cctacggtcg tcctatccgt ttcctgcgcg 28260 agaacaccac ccagtgcacc tacaactcct ccctgcgcaa ctccaccgtc gtccgcgaga 28320 acgctatctc cttcaacttc ttccagtcct acaaccagta ctacgtgttc cacatgcccc 28380 gttgcctgtt cgctggtccc ctggctgagc agttcctgaa ccaggtggac ctgaccgaga 28440 ctctcgagcg ttaccagcag cgtctgaaca cttacgctct ggtgtccaag gacctggctt 28500 cctaccgttc cttcagccag cagctgaagg ctcaggactc cctgggcgag cagcccacca 28560 ctgtgcctcc ccctatcgac ctgtccatcc cccacgtgtg gatgcccccc cagaccactc 28620 ctcacggctg gaccgagtcc cacaccacct ccggactgca ccgtccccac ttcaaccaga 28680 cctgcatcct gttcgacggt cacgacctgc tgttctccac cgtgaccccc tgcctgcacc 28740 agggcttcta cctcatcgac gagctgcgtt acgtgaagat caccctgacc gaggatttct 28800 tcgtggtcac cgtgtccatc gacgacgaca cccccatgct gctgatcttc ggtcacctcc 28860 cccgtgtgct gttcaaggct ccctaccagc gtgacaactt catcctgcgt cagaccgaga 28920 agcacgagct gctggtgctg gtcaagaagg accagctgaa ccgtcactct tacctgaagg 28980 accccgactt cctggacgct gctctggact tcaactacct ggacctgtcc gctctgctga 29040 ggaactcctt ccaccgttac gctgtggacg tgctgaagtc cggtcgttgc cagatgctgg 29100 accgtcgtac cgtcgagatg gctttcgctt acgccctggc tctgttcgct gctgctcgtc 29160 aagaagaggc tggcgctcag gtgtccgtgc cccgtgctct ggaccgtcag gctgctctgc 29220 tgcagatcca agagttcatg atcacttgcc tgtcccagac cccccctcgt accaccctgc 29280 tgctgtaccc caccgctgtg gacctggcta agcgtgctct gtggaccccc aaccagatca 29340 ccgacatcac ctccctcgtg cgtctggtgt acatcctgtc caagcagaac cagcagcacc 29400 tgatccccca gtgggctctg cgtcagatcg ctgacttcgc tctgaagctg cacaagaccc 29460 acctggcttc attcctcagc gctttcgctc gccaagagct gtacctgatg ggttccctgg 29520 tgcactccat gctggtgcac accaccgagc gtcgcgagat cttcatcgtg gaaaccggcc 29580 tgtgctccct ggccgagctg tcccacttca cccagctgct ggctcacccc caccacgagt 29640 acctgtccga cctgtacacc ccctgctcct cttccggtcg tcgtgaccac tccctggaac 29700 gtctgacccg tctgttcccc gacgctaccg tgcctaccac cgtgcctgct gctctgtcca 29760 tcctgtctac catgcagccc tccaccctgg aaaccttccc cgacctgttc tgcctgcctc 29820 tgggcgagtc cttctccgct ctgaccgtgt ccgagcacgt gtcctacgtg gtcaccaacc 29880 agtacctgat caagggcatc tcctaccccg tgtccaccac cgtcgtgggc cagtccctga 29940 tcatcaccca gaccgactcc cagaccaagt gcgagctgac ccgtaacatg cacaccactc 30000 actccatcac cgctgctctg aacatctccc tcgagaactg cgctttctgc cagtccgctc 30060 tgttggagta cgacgacact cagggtgtca tcaacatcat gtacatgcac gactccgacg 30120 acgtgctgtt cgctctggac ccctacaacg aggtggtggt gtcctccccc cgtacccact 30180 acctgatgct gctgaagaac ggcaccgtgc tggaagtgac cgacgtggtg gtggacgcta 30240 ccgaccgtct gctgatgatg tccgtgtacg ctctgtccgc tatcatcggc atctacctgc 30300 tgtaccgtat gctgaagacc tgctaaggcg ccaagctttg tcgagaagta ctagaggatc 30360 ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc 30420 cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct 30480 tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 30540 ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga 30600 tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc 30660 tgctgccacc gctgagcaat aactatcata acccctagga gatccgaacc agataagtga 30720 aatctagttc caaactattt tgtcattttt aattttcgta ttagcttacg acgctacacc 30780 cagttcccat ctattttgtc actcttccct aaataatcct taaaaactcc atttccaccc 30840 ctcccagttc ccaactattt tgtccgccca ca 30872 <210> 54 <211> 30871 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 54 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttac tgcagccacc accacaggga gttcagggtg gacaggttca 2400 cagcacgacg gtgctcaggg ggggtcaggt tgccgtaggt ggaggactgc aggctgaagt 2460 tacggatctc agacaggaac agcagggagt ccaggtagtc ccacatgggg tcgatgaagg 2520 tgcgctggaa acgggtggat ggggaggtgg gggtggtctt gttgttgtcg gaagcagtct 2580 cgttctcgac gggcatggtg tcgttgtagt acagggagga catgtccagg gtgccgtaga 2640 tggtgtaggg agtctcgtta cggatcagca cgtgagtgtt cttcatgaac tcggacacag 2700 cggtacggtt acggttgggc ttgcagaagg gctcgtcacg gtaacgcagg gtggtgtaca 2760 cccaggtagc caggtccttc agctgagtgg tcaggataga cttcatgaag ttctcgtcgg 2820 gacggtaacc gatggtagag gtggggatac gggtgggcac gatgggggag taggtcacgt 2880 tggtggaaac gttgaagatg gtggaggtgt aggaggagta gggggtagta gtgctgacgc 2940 gggacttctt ggagatggac ttcacgggag cctgcttgcg cttcagcttg cgcatggtgt 3000 tcttcagctt ggtggagttg atgtacttgg gcacacggaa gatgttacgg gacatagcgt 3060 tgaccaggta gaaggaacgg gtgcagttgc gctgagcgta acgcagcagc agagcagcca 3120 ggcccaggaa gtagatagtc tgggagtcca cgttgacctt ggaggggccc acgtacagct 3180 tggtgttcca acggggcacg ttgaagaaca tggggttgaa ggtggtgaag ttgccgcagt 3240 tttcctcgcc ggtgttgtta cgacgggaca cgttcagcat ctcggacagg caggtcatgg 3300 aggggatggt gccgcaagag gggggacgga aggtgatctt ctggccggtg tggttgtact 3360 cggagtacac gtacttagcg ggcttgcgca gctgggtggt gtggaagtcg aaccacaggt 3420 gggtgatgga gtggttacgg atgggaccag ccaggatgga gttggggggg aactgcttca 3480 tctcgacggt gatgttgtac agcttctgct ggctggggaa ggtgaagaac ttgtagtagt 3540 cgccggtctt ggaagccagc tcttgcagga tacgcagctt cagctggcgt tcctcttcct 3600 tagccttctg ggacttcaca cggaaacgag ccacagcgat cttgcagttg atgaagctga 3660 acagcaggaa ggtcagggac atcaggaaga acaggttgaa cacgccacgc atctcgccct 3720 tgcgacccat ggtggcctcg agatcccggg tgatcaagtc ttcgtcgagt gattgtaaat 3780 aaaatgtaat ttacagtata gtattttaat taatatacaa atgatttgat aataattctt 3840 atttaactat aatatattgt gttgggttga attaaaggtc cgtatactag tatcgattcg 3900 cgacctactc cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa 3960 ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc 4020 cggattattc ataccgtccc accatcgggc gcggatccgc caccatggaa aactggtccg 4080 ctctggaact gctgcccaag gtcggaatcc ctaccgactt cctgacccac gtcaagacct 4140 ccgctggcga ggaaatgttc gaggctctga ggatctacta cggcgacgac cccgagcgtt 4200 acaacatcca cttcgaggct atcttcggca ccttctgcaa ccgtctggaa tgggtgtact 4260 tcctgacttc cggcctggct gctgctgctc acgctatcaa gttccacgac ctgaacaagc 4320 tgaccaccgg caagatgctg ttccacgtgc aagtgccccg tgtggcttcc ggtgctggcc 4380 tgcctacctc ccgtcagacc accatcatgg tcaccaagta ctccgagaag tcccccatca 4440 ccatcccttt cgagctgtcc gctgcttgcc tgacttacct gcgtgaaacc ttcgagggca 4500 ccatcctgga caagatcctg aacgtcgagg ctatgcacac cgtgctgcgt gctctgaaga 4560 acaccgctga cgctatggaa cgtggcctga tccacagctt cctccagacc ctgctgagga 4620 aggctccccc ctacttcgtg gtgcagaccc tggtcgagaa cgctaccctg gctcgtcagg 4680 ctctgaaccg tatccagcgc tccaacatcc tgcagtcctt caaggctaag atgctggcta 4740 ccctgttcct gctgaaccgt acccgtgacc gtgactacgt gctgaagttc ctgacccgtc 4800 tggctgaggc tgctaccgac tccatcctcg acaaccctac tacctacacc acctcctccg 4860 gtgctaagat ctccggtgtc atggtgtcca ccgctaacgt gatgcagatc atcatgtccc 4920 tgctgtcctc ccacatcact aaggaaaccg tgtccgctcc cgctacctac ggcaacttcg 4980 tgctgtcccc cgagaacgct gtgaccgcta tctcctacca ctctatcctg gctgacttca 5040 actcctacaa ggctcacctg acctccggcc agccccacct ccccaacgac tccctgagcc 5100 aggctggtgc tcactccctg acccccctgt ccatggacgt gatccgtctg ggcgaaaaga 5160 ccgtgatcat ggaaaacctg cgtcgcgtgt acaagaacac cgacaccaag gaccccctgg 5220 aacgtaacgt ggacctgacc ttcttcttcc ccgtgggcct gtacctgccc gaggaccgtg 5280 gttacaccac cgtcgagtcc aaggtcaagc tgaacgacac cgtgcgtaac gctctgccca 5340 ccaccgctta cctgctgaac agggaccgtg ctgtgcaaaa gatcgacttc gtggacgctc 5400 tcaagaccct gtgccacccc gtgctgcacg agcctgctcc atgcctgcag gctttcaccg 5460 agcgtggtcc cccatccgag cccgctatgc agcgtctgct ggaatgccgt ttccagcaag 5520 agcccatggg tggtgctgct cgtcgtatcc cccacttcta ccgtgtgcgc cgcgaggtgc 5580 cccgtaccgt gaacgagatg aagcaggact tcgtggtcac cgacttctac aaggttggaa 5640 acatcaccct gtacaccgag ctgcaccctt tcttcgactt cacccactgc caagagaact 5700 ccgagactgt ggctctgtgc accccccgta tcgtgatcgg caacctgccc gacggcctgg 5760 ctcccggtcc cttccacgag ctgaggacct gggagatcat ggaacacatg cgcctgcgtc 5820 ccccacccga ctacgaggaa accctgcgtc tgttcaagac caccgtgacc tcccccaact 5880 accccgagct gtgctacctg gtggacgtgc tggtgcacgg caacgctgac gctttcctgc 5940 tgatccgcgc tttcatcgct cgttgcatcg tgaacatgtt ccacacccgt cagctgctgg 6000 tgttcgctca ctcctacgct ctggtcaccc tgatcgctga gcacctggct gacggtgctc 6060 tgccccccca gctcctgttc cactaccgta acctggtggc tgtgctgcgc ctggtcaccc 6120 gtatctccgc tctgcccggc ctgaacaacg gccagctggc tgaggaaccc ctgtccgctt 6180 acgtgaacgc tctgcacgac cacaggctgt ggcccccctt cgtgacccac ctccctcgta 6240 acatggaagg tgtccaggtg gtggctgatc gtcagcccct gaaccccgct aacatcgagg 6300 ctcgtcacca cggtgtctcc gacgtgcccc gtctgggtgc tatggacgct gacgagcccc 6360 tgttcgtgga cgactaccgt gctaccgacg acgagtggac cctgcaaaag gtgttctacc 6420 tgtgcctgat ccccgctatg accaacaacc gtgcttgcgg cctgggcctg aacctcaaga 6480 ctctgctggt ggacctgttc taccgtcccg ccttcctgct catgcccgct gctaccgctg 6540 tgtccacctc cggcaccacc tccaaggaat ccacctctgg tgtcaccccc gaggactccg 6600 tggctgctca gcgtcaggct gtgggcgaga tgctgaccga gctggtcgag gacgtggcca 6660 ccgacgctca cacccctctg ctgcaggctt gccgcgagct gttcctggct gtgcagttcg 6720 tgggcgagca cgtgaaggtg ctggaagtgc gtgctcccct ggaccacgct cagaggcagg 6780 gactgcccga cttcatctcc cgtcagcatg tgctgtacaa cggttgctgc gtcgtgaccg 6840 ctcctaagac cctgatcgag tactccctgc ccgtgccctt ccaccgtttc tactccaacc 6900 ccaccatctg cgctgctctg tccgacgaca tcaagcgtta cgtgaccgag ttcccccact 6960 accatagaca cgatggtggt ttccccctgc ccaccgcttt cgctcacgag taccacaact 7020 ggctgcgtag ccccttctcc cgttactccg ctacctgccc caacgtgctg cactccgtga 7080 tgaccctggc tgctatgctg tacaagatct cccccgtgtc cctggtgctg cagaccaagg 7140 ctcacatcca ccccggtttc gctctgaccg ctgtgcgtac cgacaccttc gaggtggaca 7200 tgctgctgta ctccggcaag tcctgcacct ccgtcatcat caacaacccc atcgtgacca 7260 aggaagagag ggacatctcc accacctacc acgtgaccca gaacatcaac accgtggaca 7320 tgggcctggg ttacacctcc aacacttgcg tggcctacgt gaaccgcgtc cgcaccgaca 7380 tgggtgtccg tgtgcaggac ctgttccgtg tgttccccat gaacgtgtac cgccacgatg 7440 aggtggaccg ttggatcagg cacgctgctg gcgtcgagcg tccccagctg ctggacaccg 7500 agactatctc catgctgacc ttcggttcca tgtccgagcg caacgctgct gctaccgtgc 7560 acggccagaa ggctgtctgc gagctgatcc tgacccctgt gactatggac gtgaactact 7620 tcaagatcac caacaaccct cgtggtcgtg cttcctgcat gctgggcgtg gacccctacg 7680 acaccgaggc tgccaccaag gctatctacg accaccgcga ggctgacgct cagaccttcg 7740 ctgctaccca caacccatgg gcttcccagg ctggttgcct gtccgacgtc ctgtacaaca 7800 cccgtcaccg cgagcgtctg ggctacaact ccaagttcta ctccccctgc gctcagtact 7860 tcaacaccga ggaaatcatc gctgccaaca agaccctctt caagaccatc gacgagtacc 7920 tgctgcgcgc taaggactgc atccgtggcg acaccgacac tcagtacgtg tgcgtcgagg 7980 gaaccgagca gctgatcgag aacccttgcc gtctgaccca agaggctctg cccatcctgt 8040 ccaccaccac cctggctctg atggaaacta agctgaaggg tggcgctggt gctttcgcta 8100 cctccgagac tcacttcggc aactacgtcg tgggagagat catccccctg cagcagtcca 8160 tgctgttcaa cagctaagag ctcaagcttg tcgagaagta ctagaggatc ataatcagcc 8220 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 8280 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 8340 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 8400 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 8460 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgcccac 8520 cgctgagcaa taactatcat aacccccgga atattaatag atcatggaga taattaaaat 8580 gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt tgtaataaaa 8640 aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg atccgccacc 8700 atggctgcta tggaagctaa catcttctgc accttcgacc acaagctgtc tatcgctgac 8760 gtgggcaagc tgaccaagct ggtggctgct gtggtgccca tcccccagcg tctgcacctg 8820 atcaagcact accagctggg cctgcaccag ttcgtggacc acacccgtgg ttacgtgcgt 8880 ctgcgtggcc tgctgcgtaa catgaccctg accctgatgc gtcgtgtcga gggcaaccag 8940 atcctgctgc acgtgcccac ccacggcctg ctgtacaccg tgctgaacac cggtcccgtg 9000 acctgggaga agggcgacgc tctgtgcgtg ctgccccccc tgttccacgg tcccctggct 9060 cgtgaaaacc tgttgaccct gggccagtgg gagctggtgc tgccctggat cgtgcccatg 9120 cccctggctc tggaaatcaa ccagcgcctg ctgatcatgg gcctgttctc cctggaccgt 9180 tcctacgaag aagtgaaggc tgctgtccag cagctgcaga ccatcacctt ccgtgacgct 9240 accttcacca tccccgaccc cgtgatcgac cagcacctcc tgatcgacat gaagaccgct 9300 tgcctgtcca tgtccatggt ggctaacctg gcttccgagc tgaccatgac ctacgtccgc 9360 aagctggctt tggaggactc ttccatgctg ctggtcaagt gccaagagct gctgatgcgt 9420 ctggaccgcg agcgttccgt gggcgagcct cgtactcccg ctcgtcctca gcacgtgtcc 9480 cccgacgacg agatcgctcg tctgtccgct ctgttcgtga tgctgcgtca gctggacgac 9540 ctgatccgcg agcaggtcgt gttcaccgtg tgcgacgtga gcccagacaa caagtccgct 9600 acctgcatct tcaagggcta aggcgcgcca agcttgtcga gaagtactag aggatcataa 9660 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 9720 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 9780 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 9840 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 9900 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 9960 gccaccgctg agcaataact atcataaccc ccggaatatt aatagatcat ggagataatt 10020 aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa 10080 taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccc 10140 ggtccgaagc gcgcggaatt caaaggcctg ccaccatgga aatgaacaag gtgctgcatc 10200 aggatctggt gcaggctacc cgtcgtatcc tgaagctggg cccctccgag ctgcgtgtga 10260 ccgacgctgg cctgatctgc aagaacccca actactccgt gtgcgacgct atgctcaaga 10320 ccgacaccgt gtactgcgtc gagtacctgc tgtcctactg ggagtcccgt accgaccacg 10380 tgccctgctt catcttcaag aacaccggtt gcgctgtgtc cctgtgctgc ttcgtgcgtg 10440 ctcccgtgaa gctggtgtcc cctgctcgtc acgtgggcga gttcaacgtg ctgaaggtca 10500 acgagtccct gatcgtgacc ctgaaggaca tcgaggaaat caagccctcc gcttacggtg 10560 tcctgactaa gtgcgtcgtc cgcaagtcca actccgcttc cgtgttcaac atcgagctga 10620 tcgctttcgg tcccgagaac gagggcgagt acgagaacct gctgcgcgag ctgtacgcta 10680 agaaggctgc ttccacctcc ctggctgtgc gtaaccacgt gaccgtgtcc tcccactccg 10740 gttccggtcc ctccctgtgg cgtgctcgta tgtccgctgc tctgacccgt accgctggca 10800 agcgctcctc caggactgct agccctccac caccacctcc tcgtcaccct agctgctctc 10860 ccactatggt ggctgctggt ggagctgctg ctggtcctag acctccccct cctcctatgg 10920 ctgctggatc ctggcgtctg tgccgttgcg aggcttgcat gggccgttgc ggttgcgctt 10980 ccgagggcga cgctgacgag gaagaggaag agttgctggc tctggctggc gagggcaagg 11040 ctgctgctgc cgctgccggt caagacgtcg gtggttccgc tcgtcgtccc ctcgaggaac 11100 acgtgtcccg tcgtcgtggt gtctccaccc accaccgtca ccccccttcc ccaccttgcg 11160 ctccctccct ggaacgtacc ggttaccgtt gggctccttc ctcctggtgg cgcgctcgtt 11220 ctggtccttc ccgtccccag tccggtccct ggctgcctgc tcgtttcgct accctgggtc 11280 ccctggtcct ggctctgctg ttggtgctgg ccctgctgtg gcgtggtcac ggtcaatccc 11340 ccagccccac ccgttccgct caccgtgact aaaagcttgt cgagaagtac tagaggatca 11400 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 11460 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 11520 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 11580 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 11640 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 11700 gctgtggcta gctttgttta actttaagaa ggagatacat ctagaaatat taatagatca 11760 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 11820 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 11880 gcgcggatcc cggtccgaag cgcgcggaat tcaaaggcct acgtcgacgc caccatgtcc 11940 aacaccgctc ccggtcccac cgtggctaac aagcgtgacg agaagcaccg tcacgtggtc 12000 aacgtggtgc tcgagctgcc caccgagatc tccgaggcta cccaccccgt gctggctacc 12060 atgctgtcca agtacacccg tatgtcctcc ctgttcaacg acaagtgcgc tttcaagctg 12120 gacctgctgc gtatggtggc tgtgtcccgt acccgtcgct aaaagcttgt cgagaagtac 12180 tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc 12240 ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 12300 attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 12360 tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 12420 tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc 12480 tgagttggct gctgggtgcc taatgagtga gctaactcac attaattgcc cggaatatta 12540 atagatcatg gagataatta aaatgataac catctcgcaa ataaataagt attttactgt 12600 tttcgtaaca gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc 12660 accatcgggc gcggatcccg gtccgaagcg cgcggaattc gccaccatgg acgctcgtgc 12720 tgtggctaag cgtccccgtg accccgctga cgaggacaac gagctggtca ccgctctgaa 12780 ggctaagcgt gaagtgaaca ccatctccgt gcgttacctg taccacgctg accaccaggc 12840 tctgaccgct cgtttcttcg tgcccgaggg cctggtcgag ttcgaggctc agcccggtgc 12900 tctgctgatc cgtatggaaa ccggttgcga ctccccccgt cacctgtaca tctccctgta 12960 cctgctgggt atccgtgctt ccaacgtgtc cgcttccacc cgttgcctgc tcgagtccgt 13020 gtacaccgct tccgctgctc gtgctgctct gcagtggctg gacctgggtc cccacctcct 13080 gcaccgtcgt ctggaaaccc tgggttgcgt caagaccgtg tccctgggta tcacctccct 13140 gctgacctgc gtgatgcgcg gctacctgta caacaccctc aagaccgagg tgttcgctct 13200 gatgatcccc aaggacatgt acctgacctg ggaggaaacc cgcggtcgtc tgcagtacgt 13260 gtacctgatc atcgtgtacg actacgacgg tcccgagact cgtcccggta tctacgtgct 13320 gacctcctct atcgctcact ggcagaccct ggtggacgtg gcccgtggaa agttcgctcg 13380 tgaacgctgc tccttcgtga accgtcgtat cacccgtccc cgtcagatcc ccctgtgcac 13440 cggtgtcatc caaaagctgg gctggtgcct ggctgacgac atccacacct cattcctcgt 13500 gcacaaggaa ctgaagctgt ccgtcgtgcg tctggacaac ttctccgtcg agctgggcga 13560 cttccgcgag ttcgtgcagc tgttgaattt tgaccttctt aagcttgcgg gagacgtcga 13620 gtccaaccct gggcccatgg aatcccgtgg tcgtcgttgc cccgagatga tctccgtgct 13680 gggtcccatc tccggtcacg tcctgaaggc tgtgttctcc cgtggcgaca cccccgtgct 13740 gccccacgaa actcgtctgc tgcagaccgg tatccacgtg cgtgtgtccc agccctccct 13800 gatcctggtg tcccagtaca cccccgactc caccccttgc caccgcggag acaaccagct 13860 gcaggtccag cacacctact tcaccggttc cgaggtcgag aacgtgtccg tgaacgtgca 13920 caaccccacc ggtcgttcca tctgcccctc ccaagagccc atgtccatct acgtgtacgc 13980 tctgcccctg aagatgctga acatcccctc catcaacgtg caccactacc cctccgctgc 14040 tgagcgcaag caccgtcacc tccccgtggc tgacgctgtg atccacgctt ccggcaagca 14100 gatgtggcag gctcgtctga ccgtgtccgg cctggcttgg acccgtcagc agaaccagtg 14160 gaaggaaccc gacgtgtact acacctccgc tttcgtgttc cccaccaagg acgtggccct 14220 gcgtcacgtc gtgtgcgctc acgaactcgt gtgctccatg gaaaacaccc gtgctaccaa 14280 gatgcaagtg atcggcgacc agtacgtgaa ggtgtacctg gaatccttct gcgaggacgt 14340 gccctccggc aagctgttca tgcacgtgac cctgggttcc gacgtggaag aggacctgac 14400 catgacccgt aacccccagc ccttcatgcg tccccacgag cgtaacggtt tcaccgtgct 14460 gtgccccaag aacatgatca tcaagcccgg caagatctcc cacatcatgc tggacgtggc 14520 cttcacctcc cacgagcact tcggcctgct gtgccctaag tccatccccg gcctgtccat 14580 ctccggcaac ctgctgatga acggccagca gatcttcctg gaagtgcagg ctatccgtga 14640 aaccgtcgag ctgcgtcagt acgaccctgt ggctgctctg ttcttcttcg acatcgacct 14700 gctgctgcag cgtggtcccc agtactccga gcaccccacc ttcaccagcc agtaccgtat 14760 ccagggcaag ctggaatacc gtcacacctg ggaccgtcac gacgagggtg ctgctcaggg 14820 cgacgacgac gtgtggacct ccggttccga ctccgacgag gaactggtca ccaccgagcg 14880 caagaccccc cgtgtgaccg gtggtggtgc tatggctggt gcttccacct ccgctggtcg 14940 caagcgcaag tccgcttcct ccgctaccgc ttgcaccgct ggtgtcatga cccgtggtcg 15000 cctgaaggct gagtccaccg tggctcccga agaggacact gacgaggact ccgacaacga 15060 gatccacaac cccgctgtgt tcacctggcc cccctggcag gctggtatcc tggctcgtaa 15120 cctggtgccc atggtggcta ccgtgcaggg ccagaacctg aagtaccaag agttcttctg 15180 ggacgccaac gacatctacc gtatcttcgc tgagctggaa ggcgtgtggc agcccgctgc 15240 tcagcccaag cgtcgtcgtc accgtcagga cgctctgcct ggtccctgta tcgcttccac 15300 ccccaagaag caccgcggct aaaagcttgt cgagaagtac tagaggatca taatcagcca 15360 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 15420 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 15480 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 15540 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 15600 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 15660 gctttgttta actttaagaa ggagatacat ctagacctgc aggccggaat attaatagat 15720 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 15780 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 15840 gggcgcggat cccggtccga agcgcgcgga attcgccacc atgaccatgg acgagcagca 15900 gccccaggct gtgacccccg tgtacgtggg cggtttcctg gctcgttacg accagtcccc 15960 cgacgaggct gagctgctgc tgccacgtga cgtggtcgaa cactggctgc acgctcaggg 16020 ccagggacag ccttccctgt ccgtggctct gcccctgaac atcaaccacg acgacaccgc 16080 tgtcgtgggt cacgtggccg ctatgcagtc cgtgcgtgac ggcctgttct gcctgggttg 16140 cgtgacctcc ccccgtttcc tggaaatcgt gcgtcgtgct tccgagaagt ccgagctggt 16200 gtcccgtggt cccgtgtccc cactgcagcc cgacaaggtg gtcgagttcc tgtccggttc 16260 ctacgctggc ctgtccctgt catcccgtcg ttgcgacgac gtcgaggctg ctacctccct 16320 gagcggctcc gagactaccc ccttcaagca cgtggccctg tgctccgtgg gtcgtaggcg 16380 tggaaccctg gctgtgtacg gtcgtgaccc cgagtgggtc acccagcgtt tccccgacct 16440 gaccgctgct gaccgtgacg gactgcgtgc tcagtggcag cgttgcggtt ccaccgctgt 16500 ggacgcttcc ggcgacccct tccgttccga ctcctacggc ctgctgggca actccgtgga 16560 cgctctgtac atccgcgagc gtctgcccaa gctgcgttac gacaagcagc tcgtgggtgt 16620 caccgagcgc gagtcctacg tgaaggcttc cgtgtccccc gaggctgctt gcgacatcaa 16680 ggctgcttcc gctgagcgtt ctggcgacag ccgctcccag gctgctactc ctgctgctgg 16740 tgctcgtgtg ccctccagct ccccatcccc acctgtcgag cctccctccc ccgtgcaacc 16800 tcctgctctg cctgcttccc cctccgtgct gcctgctgag tccagcccct ccctgtcacc 16860 ctctgagcct gctgaggctg cctccatgtc ccaccctctg agcgctgctg tgactgctgc 16920 taccgctccc cctggtgcta ctgtggctgg tgcttccccc gctgtgcctt ccctggcttg 16980 gcctcacgac ggtgtctacc tgcccaagga cgctttcttc tccctgctgg gcgcttcccg 17040 ttccgctgct cccgtgatgt accccggtgc tgtggctgct ccccccagcg cttcacctgc 17100 tcctctgccc ctgccctcct accccgcttc ctacggtgct cccgtcgtgg gttacgacca 17160 gctggctgct cgtcacttcg ctgactacgt ggacccccac taccccggct ggggtcgtcg 17220 ttacgagccc gctccttccc tgcacccatc ctaccctgtg ccccctcctc catcacccgc 17280 ttactaccgt cgtcgtgact cccccggtgg catggacgag cctccatctg gatgggagcg 17340 ttacgacggt tcccaccgtg gccagtccca aaagcagcac cgtcacggtg gttccggtgg 17400 tcacaacaag cgtcgcaagg aagccgctgc tgcatcctcc agctccgacg aggacctgag 17460 cttccccggc gaggctgaac acggtcgtgc tcgcaagcgt ctgaagtccc acgtgaactc 17520 cgacggaggt agcggaggcc acgctggttc caaccagcag cagcaacagc gctacgacga 17580 gctgcgtgac gctatccacg agctgaagcg tgacctgttc gctgctcgcc agtcctccac 17640 cctgctgtct gctgctctgc cagctgccgc ttcttcctcc cctaccacca ccaccgtgtg 17700 cacccctact ggcgagctga cctctggtgg tggcgagact cccaccgctc tgctgtccgg 17760 tggtgctaag gtggccgagc gtgctcaggc tggtgtcgtg aacgcttcct gccgtctggc 17820 taccgcttcc ggttccgagg ctgccaccgc tggtccctct accgctggtt cctcatcctg 17880 cccagcttcc gtggtgctgg ctgccgctgc tgctcaagcc gccgctgctt cacagtcccc 17940 cccaaaggat atggtggacc tgaaccgtcg tatcttcgtg gctgctctga acaagctcga 18000 gtaataaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 18060 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 18120 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 18180 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 18240 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 18300 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 18360 cataacccct aggggcctct aaacgggtct tgaggggttt tttgctgaaa ggaggaacta 18420 tatccggatc tgaacaggag ggacagctga tagaaacaga agccactgga gcacctcaaa 18480 aacaccatca tacactaaat cagtaagttg gcagcatcac ccgacgcact ttgcgccgaa 18540 taaatacctg tgacggaaga tcacttcgca gaataaataa atcctggtgt ccctgttgat 18600 accgggaagc cctgggccaa cttttggcga aaatgagacg ttgatcggca cgtaagaggt 18660 tccaactttc accataatga aataagatca ctaccgggcg tattttttga gttatcgaga 18720 ttttcaggag ctaaggaagc taaaatggag aaaaaaatca ctggatatac caccgttgat 18780 atatcccaat ggcatcgtaa agaacatttt gaggcatttc agtcagttgc tcaatgtacc 18840 tataaccaga ccgttcagct ggatattacg gcctttttaa agaccgtaaa gaaaaataag 18900 cacaagtttt atccggcctt tattcacatt cttgcccgcc tgatgaatgc tcatccggaa 18960 ttccgtatgg caatgaaaga cggtgagctg gtgatatggg atagtgttca cccttgttac 19020 accgttttcc atgagcaaac tgaaacgttt tcatcgctct ggagtgaata ccacgacgat 19080 ttccggcagt ttctacacat atattcgcaa gatgtggcgt gttacggtga aaacctggcc 19140 tatttcccta aagggtttat tgagaatatg tttttcgtct cagccaatcc ctgggtgagt 19200 ttcaccagtt ttgatttaaa cgtggccaat atggacaact tcttcgcccc cgttttcacc 19260 atgggcaaat attatacgca aggcgacaag gtgctgatgc cgctggcgat tcaggttcat 19320 catgccgttt gtgatggctt ccatgtcggc agaatgctta atgaattaca acagtactgc 19380 gatgagtggc agggcggggc gtaatttttt taaggcagtt attggtgccc ttaaacgcct 19440 ggttgctacg cctgaataag tgataataag cggatgaatg gcagaaattc gaaagcaaat 19500 tcgacccggt cgtcggttca gggcagggtc gttaaatagc cgcttatgtc tattgctggt 19560 ttaccggttt attgactacc ggaagcagtg tgaccgtgtg cttctcaaat gcctgaggcc 19620 agtttgctca ggctctcccc gtggaggtaa taattgacga tatgatcatt tattctgcct 19680 cccagctgac attcatccgg ggtcagcacc gtttctgcgg actggctttc tacgtgttcc 19740 gcttccttta gcagcccttg cgccctgagt gcttgcggca gcgtgaagct aattctgtca 19800 gccgttaagt gttcctgtgt cactcaaaat tgctttgaga ggctctaagg gcttctcagt 19860 gcgttacatc cctggcttgt tgtccacaac cgttaaacct taaaagcttt aaaagcctta 19920 tatattcttt tttttcttat aaaacttaaa accttagagg ctatttaagt tgctgattta 19980 tattaatttt attgttcaaa catgagagct tagtacgtga aacatgagag cttagtacgt 20040 tagccatgag agcttagtac gttagccatg agggtttagt tcgttaaaca tgagagctta 20100 gtacgttaaa catgagagct tagtacgtga aacatgagag cttagtacgt actatcaaca 20160 ggttgaactg ctgatcaaca gatcctctac gcggccgcgg taccataact tcgtatagca 20220 tacattatac gaagttatct ggtttaaacg tacccgtagt ggctatggca gggcttgccg 20280 ccccgacgtt ggctgcgagc cctgggcctt cacccgaact tgggggttgg ggtggggaaa 20340 aggaagaaac gcgggcgtat tggtcccaat ggggtctcgg tggggtatcg acagagtgcc 20400 agccctggga ccgaaccccg cgtttatgaa caaacgaccc aacacccgtg cgttttattc 20460 tgtcttttta ttgccgtcat agcgcgggtt ccttccggta ttgtctcctt ccgtgtttca 20520 gttagcctcc cccatctccc ggtaccgcat gctatgcatc agctgctagc ttagcgagcg 20580 tccacagcct ggggaccgta acgggagtga gcgggcaggt tcacacgggt ctgcttcagc 20640 tcagggggca ggccagcgta gtacttgtcc aggtgacgca gcaggggggg gtccagctgg 20700 tgacgcaggc agaattcctt cacagcgttg tacaggccgt agaacagggt gataccctcg 20760 ggagcagcag cggtggacac gggcagacgc acagcacggt tggtacgggt agcctcgtta 20820 cggatagcca ccaccacgtt gaacagggag gggggcacca gctcgaaacc cagcacgtgt 20880 tcggtgaaga tggaacgacc gtaggacaga cgagtcaggt cgtaaccacg gcacaggtcg 20940 tccacgcaag tgtacacagc gggggaaccg tcgccgcact cggagtaacc gcgcatcacg 21000 gtcatccaac ggggagcggt gtcggaggac agcagggtca gcagagcacg cagctggtcg 21060 gggttgttgt acagcagggc cagggtgtcc aggaaagcgt cgtccagcag cacggagtta 21120 gcagcctcgg gggtcacggg acggtaacgg atcagctggg acaggggacc gtccctacgg 21180 gtcacgttga ccaggggacg cagccaggac tcgtacttgt cgccctggaa cacctctccc 21240 agcaggcaac gacgggtcag ctcggggcac tcagcgggca ccttctcagc cacggtggga 21300 gccacggaca cggtagcgga ggacacgatg ggcagcagca ggcagcacca cagcagagcc 21360 acgggaccgg gggagaagga gaaaccgcag tcgggacgac ggcacatggt ggctcgagat 21420 cccgggtgat caagtcttcg tcgagtgatt gtaaataaaa tgtaatttac agtatagtat 21480 tttaattaat atacaaatga tttgataata attcttattt aactataata tattgtgttg 21540 ggttgaatta aaggtccgta tactagtatc gattcgcgac ctactccgga atattaatag 21600 atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc 21660 gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca 21720 tcgggcgcgg atccgccacc atgaactcca aggacctgac ccccttcctg accaccctgt 21780 ggctgctgct ggaccactcc cgtgtgcctc gtgtgcgtgc tgaggaatgc tgcgaagtga 21840 tcaacgtgaa ccaccccccc gagcgctgct acgacttcaa gatgtgcaac ctgttcaccg 21900 tggctctgcg ttgccccgac ggcgaagtgt gctactcccc cgaaaagacc gctgagatcc 21960 gtggtatcgt gaccaccatg acccactccc tgacccgtca agtgatccac aacaagctga 22020 ccagctgcaa ctacaacccc ctgtacctcg aggctgacgg tcgtatccgt tgcggcaagg 22080 tgtccgacaa ggctcagtac ctgctgggtg ctgctggttc cgtgccctac cgttggatca 22140 acctcgagta cgacaagatc acccgtatcg tgggcctgga ccagtacctc gagtccgtga 22200 agaagcacaa gcgtctggac gtgtgccgtg ctaagatggg ttacatgctg cagtaaaagc 22260 ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag gttttacttg 22320 ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg 22380 ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt 22440 tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg 22500 tatcttatca tgtctggatt gatcactgct tgagcctaga agatccggct gctaacaaag 22560 cccgaaagga agctgagttg gctgctgtgg ctagctttgt ttaactttaa gaaggagata 22620 catctagacc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 22680 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 22740 ggattattca taccgtccca ccatcgggcg cggatccgcc accatgctgc gtctgctgct 22800 gcgtcaccac ttccactgcc tgctgctgtg cgctgtgtgg gctaccccct gcctggcttc 22860 cccttggtcc accctgaccg ctaaccagaa cccctcccca ccctggtcca agctgaccta 22920 ctccaagccc cacgacgctg ctaccttcta ctgccccttc ctgtacccat ccccccctcg 22980 ttccccactg cagttctccg gtttccagcg tgtgctgacc ggtcccgagt gccgtaacga 23040 gactctgtac ctgctgtaca accgcgaggg ccagaccctg gtcgagaggt cctccacctg 23100 ggtcaagaag gtcatctggt acttgtccgg tcgtaaccag accatcctgc agcgtatgcc 23160 ccgtaccgct tccaagccct ccgacggcaa cgtgcagatc tccgtcgagg acgctaagat 23220 cttcggtgct cacatggtgc ccaagcagac caagctgctg cgtttcgtgg tcaacgacgg 23280 cacccgttac cagatgtgcg tgatgaagct cgagtcctgg gctcacgtgt tccgtgacta 23340 ctccgtgtcc ttccaagtgc gcctgacctt caccgaggct aacaaccaga cctacacctt 23400 ctgcacccac cccaacctga tcgtgtaaaa gcttgtcgag aagtactaga ggatcataat 23460 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 23520 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 23580 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 23640 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 23700 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 23760 ggtgcctaat gagtgagcta actcacatta attgcccgga atattaatag atcatggaga 23820 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 23880 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 23940 atccgccacc atgcgtctgt gccgtgtgtg gctgtccgtg tgcctgtgcg ctgtggtgct 24000 gggccagtgc cagcgtgaaa ccgctgagaa gaacgactac taccgtgtgc cccactactg 24060 ggacgcttgc tcccgtgctc tgcccgacca gacccgttac aagtacgtcg agcagctggt 24120 ggacctgacc ctgaactacc actacgacgc ttcccacggc ctggacaact tcgacgtgct 24180 gaagcgtatc aacgtgaccg aggtgtccct gctgatctcc gacttccgtc gtcagaaccg 24240 tcgtggtggc accaacaagc gtaccacctt caacgctgct ggttccctgg ctccccacgc 24300 tcgttccctc gagttctccg tgcgtctgtt cgctaactaa aagcttgtcg agaagtacta 24360 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 24420 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 24480 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 24540 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 24600 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 24660 agttggctgc tgccaccgct gagcaataac tatcataacc cccggaatat taatagatca 24720 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 24780 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 24840 gcgcggatcc cggtccgaag cgcgcggaat tcaaaggcct accgtcgacg ccaccatgga 24900 atcccgtatc tggtgcctgg tcgtgtgcgt gaacctgtgc atcgtgtgcc tgggtgctgc 24960 tgtgtcctcc tcctccaccc gtggcacctc cgctacccac tcccaccact cctcccacac 25020 cacctccgcc gctcactccc gttccggttc cgtgtcccag cgtgtgacct cctcccagac 25080 cgtgtcccac ggtgtcaacg agactatcta caacaccacc ctgaagtacg gcgacgtcgt 25140 gggtgtcaac accaccaagt acccctaccg tgtgtgctcc atggctcagg gcaccgacct 25200 gatccgtttc gagcgtaaca tcgtgtgcac ctccatgaag cccatcaacg aggacctgga 25260 cgagggtatc atggtggtgt acaagcgcaa catcgtggct cacaccttca aggtccgcgt 25320 gtaccagaag gtgctgacct tccgtcgttc ctacgcttac atccacacca cttacctgct 25380 gggttccaac accgagtacg tggcccctcc catgtgggag atccaccaca tcaactccca 25440 ctcccagtgc tactcctctt actcccgtgt gatcgctggc accgtgttcg tggcttacca 25500 ccgtgactcc tacgagaaca agaccatgca gctgatgccc gacgactact ccaacaccca 25560 ctccacccgt tacgtgaccg tgaaggacca gtggcactcc cgtggttcca cctggctgta 25620 ccgtgaaacc tgcaacctga actgcatggt caccatcacc accgctcgtt ccaagtaccc 25680 ttaccacttc ttcgctacct ccaccggcga cgtggtggac atctccccct tctacaacgg 25740 tactaaccgt aacgcttcct acttcggcga gaacgctgac aagttcttca tcttccccaa 25800 ctacaccatc gtgtccgact tcggtcgtcc caactccgct ctggaaaccc accgtctggt 25860 ggctttcttg gagcgtgctg actccgtgat ctcctgggac atccaggacg agaagaacgt 25920 gacctgccag ctgaccttct gggaggcttc cgagcgtacc atccgttccg aggctgagga 25980 ctcctaccac ttctccagcg ctaagatgac cgctaccttc ctgtccaaga aacaagaggt 26040 caacatgtcc gactccgccc tggactgcgt gcgtgacgag gctatcaaca agctgcagca 26100 gatcttcaac acctcctaca accagaccta cgagaagtac ggaaacgtgt ccgtgttcga 26160 gactaccggt ggcctggtgg tgttctggca gggtatcaag cagaagtccc tggtcgagct 26220 ggaacgtctg gctaaccgtt cctccctgaa cctgacccac aaccgtacca agcgttccac 26280 cgacggcaac aacgctactc acctgtccaa catggaatcc gtgcacaacc tggtgtacgc 26340 tcagctgcag ttcacctacg acaccctgcg cggttacatc aaccgtgctc tggctcagat 26400 cgctgaggct tggtgcgtgg accagcgtcg taccctggaa gtgttcaagg aactgtccaa 26460 gatcaacccc tccgctatcc tgtccgccat ctacaacaag cctatcgctg ctcgtttcat 26520 gggcgacgtg ctgggcctgg cttcctgcgt gaccatcaac cagacttccg tgaaggtgct 26580 gcgtgacatg aacgtgaagg aatcccccgg tcgttgctac tcccgtcccg tggtcatctt 26640 caacttcgct aactcctcct acgtgcagta cggccagctg ggcgaggaca acgagatcct 26700 gctgggcaac caccgtaccg aggaatgcca gctgccctcc ctgaagatct tcatcgctgg 26760 caactccgct tacgaatacg tggactacct gttcaagcgc atgatcgacc tgtcctccat 26820 ctctaccgtg gactccatga tcgctctgga catcgacccc ctggaaaaca ccgacttccg 26880 tgtgctggaa ctgtactccc agaaggaact gcgttccatc aacgtgttcg acctggaaga 26940 gatcatgcgc gagttcaact cctacaagca gcgtgttaag tacgtcgagg acaaggtggt 27000 ggaccccctg cccccctacc tgaagggact ggacgacctg atgtccggcc tgggagctgc 27060 cggcaaggct gtgggtgtcg ctatcggtgc tgtgggtggt gctgtggctt ccgtggtcga 27120 gggtgtcgcc accttcctga agaacccctt cggtgctttc accatcatcc tggtggctat 27180 cgctgtggtc atcatcatct acctgatcta cacccgtcag cgtcgtctgt gcatgcagcc 27240 cctgcagaac ctgttcccct acctggtgtc cgctgacggt actaccgtga cctccggcaa 27300 caccaaggac acctccctgc aggctccccc atcctacgag gaatccgtct acaactccgg 27360 tcgcaagggt cccggtcccc cttcctccga cgcttctacc gctgctcccc catacaccaa 27420 cgagcaggct taccagatgc tgctggctct cgtgcgtctg gacgctgagc agcgtgcaca 27480 gcagaacggc accgactccc tggacggcca gaccggaacc caggacaagg gccagaagcc 27540 caacctgctg gaccgtctgc gtcaccgcaa gaacggttac cgtcacctga aggactccga 27600 cgaggaagag aacgtctaag gcgcgccaag cttgtcgaga agtactagag atcataatca 27660 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 27720 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 27780 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 27840 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 27900 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgggaa tattaataga 27960 tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt actgttttcg 28020 taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc gtcccaccat 28080 cgggcgcgga tccgccacca tgcgtcccgg cctgccctcc tacctgatcg tgctggctgt 28140 gtgcctgctg tcccacctcc tgtcctcccg ttacggtgct gaggctatct ccgagcccct 28200 ggacaaggct ttccacctcc tgctgaacac ctacggtcgt cctatccgtt tcctgcgcga 28260 gaacaccacc cagtgcacct acaactcctc cctgcgcaac tccaccgtcg tccgcgagaa 28320 cgctatctcc ttcaacttct tccagtccta caaccagtac tacgtgttcc acatgccccg 28380 ttgcctgttc gctggtcccc tggctgagca gttcctgaac caggtggacc tgaccgagac 28440 tctcgagcgt taccagcagc gtctgaacac ttacgctctg gtgtccaagg acctggcttc 28500 ctaccgttcc ttcagccagc agctgaaggc tcaggactcc ctgggcgagc agcccaccac 28560 tgtgcctccc cctatcgacc tgtccatccc ccacgtgtgg atgccccccc agaccactcc 28620 tcacggctgg accgagtccc acaccacctc cggactgcac cgtccccact tcaaccagac 28680 ctgcatcctg ttcgacggtc acgacctgct gttctccacc gtgaccccct gcctgcacca 28740 gggcttctac ctcatcgacg agctgcgtta cgtgaagatc accctgaccg aggatttctt 28800 cgtggtcacc gtgtccatcg acgacgacac ccccatgctg ctgatcttcg gtcacctccc 28860 ccgtgtgctg ttcaaggctc cctaccagcg tgacaacttc atcctgcgtc agaccgagaa 28920 gcacgagctg ctggtgctgg tcaagaagga ccagctgaac cgtcactctt acctgaagga 28980 ccccgacttc ctggacgctg ctctggactt caactacctg gacctgtccg ctctgctgag 29040 gaactccttc caccgttacg ctgtggacgt gctgaagtcc ggtcgttgcc agatgctgga 29100 ccgtcgtacc gtcgagatgg ctttcgctta cgccctggct ctgttcgctg ctgctcgtca 29160 agaagaggct ggcgctcagg tgtccgtgcc ccgtgctctg gaccgtcagg ctgctctgct 29220 gcagatccaa gagttcatga tcacttgcct gtcccagacc ccccctcgta ccaccctgct 29280 gctgtacccc accgctgtgg acctggctaa gcgtgctctg tggaccccca accagatcac 29340 cgacatcacc tccctcgtgc gtctggtgta catcctgtcc aagcagaacc agcagcacct 29400 gatcccccag tgggctctgc gtcagatcgc tgacttcgct ctgaagctgc acaagaccca 29460 cctggcttca ttcctcagcg ctttcgctcg ccaagagctg tacctgatgg gttccctggt 29520 gcactccatg ctggtgcaca ccaccgagcg tcgcgagatc ttcatcgtgg aaaccggcct 29580 gtgctccctg gccgagctgt cccacttcac ccagctgctg gctcaccccc accacgagta 29640 cctgtccgac ctgtacaccc cctgctcctc ttccggtcgt cgtgaccact ccctggaacg 29700 tctgacccgt ctgttccccg acgctaccgt gcctaccacc gtgcctgctg ctctgtccat 29760 cctgtctacc atgcagccct ccaccctgga aaccttcccc gacctgttct gcctgcctct 29820 gggcgagtcc ttctccgctc tgaccgtgtc cgagcacgtg tcctacgtgg tcaccaacca 29880 gtacctgatc aagggcatct cctaccccgt gtccaccacc gtcgtgggcc agtccctgat 29940 catcacccag accgactccc agaccaagtg cgagctgacc cgtaacatgc acaccactca 30000 ctccatcacc gctgctctga acatctccct cgagaactgc gctttctgcc agtccgctct 30060 gttggagtac gacgacactc agggtgtcat caacatcatg tacatgcacg actccgacga 30120 cgtgctgttc gctctggacc cctacaacga ggtggtggtg tcctcccccc gtacccacta 30180 cctgatgctg ctgaagaacg gcaccgtgct ggaagtgacc gacgtggtgg tggacgctac 30240 cgaccgtctg ctgatgatgt ccgtgtacgc tctgtccgct atcatcggca tctacctgct 30300 gtaccgtatg ctgaagacct gctaaggcgc caagctttgt cgagaagtac tagaggatca 30360 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 30420 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 30480 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 30540 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 30600 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 30660 gctgccaccg ctgagcaata actatcataa cccctaggag atccgaacca gataagtgaa 30720 atctagttcc aaactatttt gtcattttta attttcgtat tagcttacga cgctacaccc 30780 agttcccatc tattttgtca ctcttcccta aataatcctt aaaaactcca tttccacccc 30840 tcccagttcc caactatttt gtccgcccac a 30871 <210> 55 <211> 32059 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 55 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttac tgcagccacc accacaggga gttcagggtg gacaggttca 2400 cagcacgacg gtgctcaggg ggggtcaggt tgccgtaggt ggaggactgc aggctgaagt 2460 tacggatctc agacaggaac agcagggagt ccaggtagtc ccacatgggg tcgatgaagg 2520 tgcgctggaa acgggtggat ggggaggtgg gggtggtctt gttgttgtcg gaagcagtct 2580 cgttctcgac gggcatggtg tcgttgtagt acagggagga catgtccagg gtgccgtaga 2640 tggtgtaggg agtctcgtta cggatcagca cgtgagtgtt cttcatgaac tcggacacag 2700 cggtacggtt acggttgggc ttgcagaagg gctcgtcacg gtaacgcagg gtggtgtaca 2760 cccaggtagc caggtccttc agctgagtgg tcaggataga cttcatgaag ttctcgtcgg 2820 gacggtaacc gatggtagag gtggggatac gggtgggcac gatgggggag taggtcacgt 2880 tggtggaaac gttgaagatg gtggaggtgt aggaggagta gggggtagta gtgctgacgc 2940 gggacttctt ggagatggac ttcacgggag cctgcttgcg cttcagcttg cgcatggtgt 3000 tcttcagctt ggtggagttg atgtacttgg gcacacggaa gatgttacgg gacatagcgt 3060 tgaccaggta gaaggaacgg gtgcagttgc gctgagcgta acgcagcagc agagcagcca 3120 ggcccaggaa gtagatagtc tgggagtcca cgttgacctt ggaggggccc acgtacagct 3180 tggtgttcca acggggcacg ttgaagaaca tggggttgaa ggtggtgaag ttgccgcagt 3240 tttcctcgcc ggtgttgtta cgacgggaca cgttcagcat ctcggacagg caggtcatgg 3300 aggggatggt gccgcaagag gggggacgga aggtgatctt ctggccggtg tggttgtact 3360 cggagtacac gtacttagcg ggcttgcgca gctgggtggt gtggaagtcg aaccacaggt 3420 gggtgatgga gtggttacgg atgggaccag ccaggatgga gttggggggg aactgcttca 3480 tctcgacggt gatgttgtac agcttctgct ggctggggaa ggtgaagaac ttgtagtagt 3540 cgccggtctt ggaagccagc tcttgcagga tacgcagctt cagctggcgt tcctcttcct 3600 tagccttctg ggacttcaca cggaaacgag ccacagcgat cttgcagttg atgaagctga 3660 acagcaggaa ggtcagggac atcaggaaga acaggttgaa cacgccacgc atctcgccct 3720 tgcgacccat ggtggcctcg agatcccggg tgatcaagtc ttcgtcgagt gattgtaaat 3780 aaaatgtaat ttacagtata gtattttaat taatatacaa atgatttgat aataattctt 3840 atttaactat aatatattgt gttgggttga attaaaggtc cgtatactag tatcgattcg 3900 cgacctactc cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa 3960 ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc 4020 cggattattc ataccgtccc accatcgggc gcggatccgc caccatggaa aactggtccg 4080 ctctggaact gctgcccaag gtcggaatcc ctaccgactt cctgacccac gtcaagacct 4140 ccgctggcga ggaaatgttc gaggctctga ggatctacta cggcgacgac cccgagcgtt 4200 acaacatcca cttcgaggct atcttcggca ccttctgcaa ccgtctggaa tgggtgtact 4260 tcctgacttc cggcctggct gctgctgctc acgctatcaa gttccacgac ctgaacaagc 4320 tgaccaccgg caagatgctg ttccacgtgc aagtgccccg tgtggcttcc ggtgctggcc 4380 tgcctacctc ccgtcagacc accatcatgg tcaccaagta ctccgagaag tcccccatca 4440 ccatcccttt cgagctgtcc gctgcttgcc tgacttacct gcgtgaaacc ttcgagggca 4500 ccatcctgga caagatcctg aacgtcgagg ctatgcacac cgtgctgcgt gctctgaaga 4560 acaccgctga cgctatggaa cgtggcctga tccacagctt cctccagacc ctgctgagga 4620 aggctccccc ctacttcgtg gtgcagaccc tggtcgagaa cgctaccctg gctcgtcagg 4680 ctctgaaccg tatccagcgc tccaacatcc tgcagtcctt caaggctaag atgctggcta 4740 ccctgttcct gctgaaccgt acccgtgacc gtgactacgt gctgaagttc ctgacccgtc 4800 tggctgaggc tgctaccgac tccatcctcg acaaccctac tacctacacc acctcctccg 4860 gtgctaagat ctccggtgtc atggtgtcca ccgctaacgt gatgcagatc atcatgtccc 4920 tgctgtcctc ccacatcact aaggaaaccg tgtccgctcc cgctacctac ggcaacttcg 4980 tgctgtcccc cgagaacgct gtgaccgcta tctcctacca ctctatcctg gctgacttca 5040 actcctacaa ggctcacctg acctccggcc agccccacct ccccaacgac tccctgagcc 5100 aggctggtgc tcactccctg acccccctgt ccatggacgt gatccgtctg ggcgaaaaga 5160 ccgtgatcat ggaaaacctg cgtcgcgtgt acaagaacac cgacaccaag gaccccctgg 5220 aacgtaacgt ggacctgacc ttcttcttcc ccgtgggcct gtacctgccc gaggaccgtg 5280 gttacaccac cgtcgagtcc aaggtcaagc tgaacgacac cgtgcgtaac gctctgccca 5340 ccaccgctta cctgctgaac agggaccgtg ctgtgcaaaa gatcgacttc gtggacgctc 5400 tcaagaccct gtgccacccc gtgctgcacg agcctgctcc atgcctgcag gctttcaccg 5460 agcgtggtcc cccatccgag cccgctatgc agcgtctgct ggaatgccgt ttccagcaag 5520 agcccatggg tggtgctgct cgtcgtatcc cccacttcta ccgtgtgcgc cgcgaggtgc 5580 cccgtaccgt gaacgagatg aagcaggact tcgtggtcac cgacttctac aaggttggaa 5640 acatcaccct gtacaccgag ctgcaccctt tcttcgactt cacccactgc caagagaact 5700 ccgagactgt ggctctgtgc accccccgta tcgtgatcgg caacctgccc gacggcctgg 5760 ctcccggtcc cttccacgag ctgaggacct gggagatcat ggaacacatg cgcctgcgtc 5820 ccccacccga ctacgaggaa accctgcgtc tgttcaagac caccgtgacc tcccccaact 5880 accccgagct gtgctacctg gtggacgtgc tggtgcacgg caacgctgac gctttcctgc 5940 tgatccgcgc tttcatcgct cgttgcatcg tgaacatgtt ccacacccgt cagctgctgg 6000 tgttcgctca ctcctacgct ctggtcaccc tgatcgctga gcacctggct gacggtgctc 6060 tgccccccca gctcctgttc cactaccgta acctggtggc tgtgctgcgc ctggtcaccc 6120 gtatctccgc tctgcccggc ctgaacaacg gccagctggc tgaggaaccc ctgtccgctt 6180 acgtgaacgc tctgcacgac cacaggctgt ggcccccctt cgtgacccac ctccctcgta 6240 acatggaagg tgtccaggtg gtggctgatc gtcagcccct gaaccccgct aacatcgagg 6300 ctcgtcacca cggtgtctcc gacgtgcccc gtctgggtgc tatggacgct gacgagcccc 6360 tgttcgtgga cgactaccgt gctaccgacg acgagtggac cctgcaaaag gtgttctacc 6420 tgtgcctgat ccccgctatg accaacaacc gtgcttgcgg cctgggcctg aacctcaaga 6480 ctctgctggt ggacctgttc taccgtcccg ccttcctgct catgcccgct gctaccgctg 6540 tgtccacctc cggcaccacc tccaaggaat ccacctctgg tgtcaccccc gaggactccg 6600 tggctgctca gcgtcaggct gtgggcgaga tgctgaccga gctggtcgag gacgtggcca 6660 ccgacgctca cacccctctg ctgcaggctt gccgcgagct gttcctggct gtgcagttcg 6720 tgggcgagca cgtgaaggtg ctggaagtgc gtgctcccct ggaccacgct cagaggcagg 6780 gactgcccga cttcatctcc cgtcagcatg tgctgtacaa cggttgctgc gtcgtgaccg 6840 ctcctaagac cctgatcgag tactccctgc ccgtgccctt ccaccgtttc tactccaacc 6900 ccaccatctg cgctgctctg tccgacgaca tcaagcgtta cgtgaccgag ttcccccact 6960 accatagaca cgatggtggt ttccccctgc ccaccgcttt cgctcacgag taccacaact 7020 ggctgcgtag ccccttctcc cgttactccg ctacctgccc caacgtgctg cactccgtga 7080 tgaccctggc tgctatgctg tacaagatct cccccgtgtc cctggtgctg cagaccaagg 7140 ctcacatcca ccccggtttc gctctgaccg ctgtgcgtac cgacaccttc gaggtggaca 7200 tgctgctgta ctccggcaag tcctgcacct ccgtcatcat caacaacccc atcgtgacca 7260 aggaagagag ggacatctcc accacctacc acgtgaccca gaacatcaac accgtggaca 7320 tgggcctggg ttacacctcc aacacttgcg tggcctacgt gaaccgcgtc cgcaccgaca 7380 tgggtgtccg tgtgcaggac ctgttccgtg tgttccccat gaacgtgtac cgccacgatg 7440 aggtggaccg ttggatcagg cacgctgctg gcgtcgagcg tccccagctg ctggacaccg 7500 agactatctc catgctgacc ttcggttcca tgtccgagcg caacgctgct gctaccgtgc 7560 acggccagaa ggctgtctgc gagctgatcc tgacccctgt gactatggac gtgaactact 7620 tcaagatcac caacaaccct cgtggtcgtg cttcctgcat gctgggcgtg gacccctacg 7680 acaccgaggc tgccaccaag gctatctacg accaccgcga ggctgacgct cagaccttcg 7740 ctgctaccca caacccatgg gcttcccagg ctggttgcct gtccgacgtc ctgtacaaca 7800 cccgtcaccg cgagcgtctg ggctacaact ccaagttcta ctccccctgc gctcagtact 7860 tcaacaccga ggaaatcatc gctgccaaca agaccctctt caagaccatc gacgagtacc 7920 tgctgcgcgc taaggactgc atccgtggcg acaccgacac tcagtacgtg tgcgtcgagg 7980 gaaccgagca gctgatcgag aacccttgcc gtctgaccca agaggctctg cccatcctgt 8040 ccaccaccac cctggctctg atggaaacta agctgaaggg tggcgctggt gctttcgcta 8100 cctccgagac tcacttcggc aactacgtcg tgggagagat catccccctg cagcagtcca 8160 tgctgttcaa cagctaagag ctcaagcttg tcgagaagta ctagaggatc ataatcagcc 8220 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 8280 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 8340 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 8400 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 8460 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgcccac 8520 cgctgagcaa taactatcat aacccccgga atattaatag atcatggaga taattaaaat 8580 gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt tgtaataaaa 8640 aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg atccgccacc 8700 atggctgcta tggaagctaa catcttctgc accttcgacc acaagctgtc tatcgctgac 8760 gtgggcaagc tgaccaagct ggtggctgct gtggtgccca tcccccagcg tctgcacctg 8820 atcaagcact accagctggg cctgcaccag ttcgtggacc acacccgtgg ttacgtgcgt 8880 ctgcgtggcc tgctgcgtaa catgaccctg accctgatgc gtcgtgtcga gggcaaccag 8940 atcctgctgc acgtgcccac ccacggcctg ctgtacaccg tgctgaacac cggtcccgtg 9000 acctgggaga agggcgacgc tctgtgcgtg ctgccccccc tgttccacgg tcccctggct 9060 cgtgaaaacc tgttgaccct gggccagtgg gagctggtgc tgccctggat cgtgcccatg 9120 cccctggctc tggaaatcaa ccagcgcctg ctgatcatgg gcctgttctc cctggaccgt 9180 tcctacgaag aagtgaaggc tgctgtccag cagctgcaga ccatcacctt ccgtgacgct 9240 accttcacca tccccgaccc cgtgatcgac cagcacctcc tgatcgacat gaagaccgct 9300 tgcctgtcca tgtccatggt ggctaacctg gcttccgagc tgaccatgac ctacgtccgc 9360 aagctggctt tggaggactc ttccatgctg ctggtcaagt gccaagagct gctgatgcgt 9420 ctggaccgcg agcgttccgt gggcgagcct cgtactcccg ctcgtcctca gcacgtgtcc 9480 cccgacgacg agatcgctcg tctgtccgct ctgttcgtga tgctgcgtca gctggacgac 9540 ctgatccgcg agcaggtcgt gttcaccgtg tgcgacgtga gcccagacaa caagtccgct 9600 acctgcatct tcaagggcta aggcgcgcca agcttgtcga gaagtactag aggatcataa 9660 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 9720 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 9780 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 9840 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 9900 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 9960 gccaccgctg agcaataact atcataaccc ccggaatatt aatagatcat ggagataatt 10020 aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa 10080 taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccc 10140 ggtccgaagc gcgcggaatt caaaggcctg ccaccatgga aatgaacaag gtgctgcatc 10200 aggatctggt gcaggctacc cgtcgtatcc tgaagctggg cccctccgag ctgcgtgtga 10260 ccgacgctgg cctgatctgc aagaacccca actactccgt gtgcgacgct atgctcaaga 10320 ccgacaccgt gtactgcgtc gagtacctgc tgtcctactg ggagtcccgt accgaccacg 10380 tgccctgctt catcttcaag aacaccggtt gcgctgtgtc cctgtgctgc ttcgtgcgtg 10440 ctcccgtgaa gctggtgtcc cctgctcgtc acgtgggcga gttcaacgtg ctgaaggtca 10500 acgagtccct gatcgtgacc ctgaaggaca tcgaggaaat caagccctcc gcttacggtg 10560 tcctgactaa gtgcgtcgtc cgcaagtcca actccgcttc cgtgttcaac atcgagctga 10620 tcgctttcgg tcccgagaac gagggcgagt acgagaacct gctgcgcgag ctgtacgcta 10680 agaaggctgc ttccacctcc ctggctgtgc gtaaccacgt gaccgtgtcc tcccactccg 10740 gttccggtcc ctccctgtgg cgtgctcgta tgtccgctgc tctgacccgt accgctggca 10800 agcgctcctc caggactgct agccctccac caccacctcc tcgtcaccct agctgctctc 10860 ccactatggt ggctgctggt ggagctgctg ctggtcctag acctccccct cctcctatgg 10920 ctgctggatc ctggcgtctg tgccgttgcg aggcttgcat gggccgttgc ggttgcgctt 10980 ccgagggcga cgctgacgag gaagaggaag agttgctggc tctggctggc gagggcaagg 11040 ctgctgctgc cgctgccggt caagacgtcg gtggttccgc tcgtcgtccc ctcgaggaac 11100 acgtgtcccg tcgtcgtggt gtctccaccc accaccgtca ccccccttcc ccaccttgcg 11160 ctccctccct ggaacgtacc ggttaccgtt gggctccttc ctcctggtgg cgcgctcgtt 11220 ctggtccttc ccgtccccag tccggtccct ggctgcctgc tcgtttcgct accctgggtc 11280 ccctggtcct ggctctgctg ttggtgctgg ccctgctgtg gcgtggtcac ggtcaatccc 11340 ccagccccac ccgttccgct caccgtgact aaaagcttgt cgagaagtac tagaggatca 11400 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 11460 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 11520 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 11580 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 11640 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 11700 gctgtggcta gctttgttta actttaagaa ggagatacat ctagaaatat taatagatca 11760 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 11820 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 11880 gcgcggatcc cggtccgaag cgcgcggaat tcaaaggcct acgtcgacgc caccatgtcc 11940 aacaccgctc ccggtcccac cgtggctaac aagcgtgacg agaagcaccg tcacgtggtc 12000 aacgtggtgc tcgagctgcc caccgagatc tccgaggcta cccaccccgt gctggctacc 12060 atgctgtcca agtacacccg tatgtcctcc ctgttcaacg acaagtgcgc tttcaagctg 12120 gacctgctgc gtatggtggc tgtgtcccgt acccgtcgct aaaagcttgt cgagaagtac 12180 tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc 12240 ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 12300 attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 12360 tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 12420 tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc 12480 tgagttggct gctgggtgcc taatgagtga gctaactcac attaattgcc cggaatatta 12540 atagatcatg gagataatta aaatgataac catctcgcaa ataaataagt attttactgt 12600 tttcgtaaca gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc 12660 accatcgggc gcggatcccg gtccgaagcg cgcggaattc gccaccatgg acgctcgtgc 12720 tgtggctaag cgtccccgtg accccgctga cgaggacaac gagctggtca ccgctctgaa 12780 ggctaagcgt gaagtgaaca ccatctccgt gcgttacctg taccacgctg accaccaggc 12840 tctgaccgct cgtttcttcg tgcccgaggg cctggtcgag ttcgaggctc agcccggtgc 12900 tctgctgatc cgtatggaaa ccggttgcga ctccccccgt cacctgtaca tctccctgta 12960 cctgctgggt atccgtgctt ccaacgtgtc cgcttccacc cgttgcctgc tcgagtccgt 13020 gtacaccgct tccgctgctc gtgctgctct gcagtggctg gacctgggtc cccacctcct 13080 gcaccgtcgt ctggaaaccc tgggttgcgt caagaccgtg tccctgggta tcacctccct 13140 gctgacctgc gtgatgcgcg gctacctgta caacaccctc aagaccgagg tgttcgctct 13200 gatgatcccc aaggacatgt acctgacctg ggaggaaacc cgcggtcgtc tgcagtacgt 13260 gtacctgatc atcgtgtacg actacgacgg tcccgagact cgtcccggta tctacgtgct 13320 gacctcctct atcgctcact ggcagaccct ggtggacgtg gcccgtggaa agttcgctcg 13380 tgaacgctgc tccttcgtga accgtcgtat cacccgtccc cgtcagatcc ccctgtgcac 13440 cggtgtcatc caaaagctgg gctggtgcct ggctgacgac atccacacct cattcctcgt 13500 gcacaaggaa ctgaagctgt ccgtcgtgcg tctggacaac ttctccgtcg agctgggcga 13560 cttccgcgag ttcgtgcagc tgttgaattt tgaccttctt aagcttgcgg gagacgtcga 13620 gtccaaccct gggcccatgg aatcccgtgg tcgtcgttgc cccgagatga tctccgtgct 13680 gggtcccatc tccggtcacg tcctgaaggc tgtgttctcc cgtggcgaca cccccgtgct 13740 gccccacgaa actcgtctgc tgcagaccgg tatccacgtg cgtgtgtccc agccctccct 13800 gatcctggtg tcccagtaca cccccgactc caccccttgc caccgcggag acaaccagct 13860 gcaggtccag cacacctact tcaccggttc cgaggtcgag aacgtgtccg tgaacgtgca 13920 caaccccacc ggtcgttcca tctgcccctc ccaagagccc atgtccatct acgtgtacgc 13980 tctgcccctg aagatgctga acatcccctc catcaacgtg caccactacc cctccgctgc 14040 tgagcgcaag caccgtcacc tccccgtggc tgacgctgtg atccacgctt ccggcaagca 14100 gatgtggcag gctcgtctga ccgtgtccgg cctggcttgg acccgtcagc agaaccagtg 14160 gaaggaaccc gacgtgtact acacctccgc tttcgtgttc cccaccaagg acgtggccct 14220 gcgtcacgtc gtgtgcgctc acgaactcgt gtgctccatg gaaaacaccc gtgctaccaa 14280 gatgcaagtg atcggcgacc agtacgtgaa ggtgtacctg gaatccttct gcgaggacgt 14340 gccctccggc aagctgttca tgcacgtgac cctgggttcc gacgtggaag aggacctgac 14400 catgacccgt aacccccagc ccttcatgcg tccccacgag cgtaacggtt tcaccgtgct 14460 gtgccccaag aacatgatca tcaagcccgg caagatctcc cacatcatgc tggacgtggc 14520 cttcacctcc cacgagcact tcggcctgct gtgccctaag tccatccccg gcctgtccat 14580 ctccggcaac ctgctgatga acggccagca gatcttcctg gaagtgcagg ctatccgtga 14640 aaccgtcgag ctgcgtcagt acgaccctgt ggctgctctg ttcttcttcg acatcgacct 14700 gctgctgcag cgtggtcccc agtactccga gcaccccacc ttcaccagcc agtaccgtat 14760 ccagggcaag ctggaatacc gtcacacctg ggaccgtcac gacgagggtg ctgctcaggg 14820 cgacgacgac gtgtggacct ccggttccga ctccgacgag gaactggtca ccaccgagcg 14880 caagaccccc cgtgtgaccg gtggtggtgc tatggctggt gcttccacct ccgctggtcg 14940 caagcgcaag tccgcttcct ccgctaccgc ttgcaccgct ggtgtcatga cccgtggtcg 15000 cctgaaggct gagtccaccg tggctcccga agaggacact gacgaggact ccgacaacga 15060 gatccacaac cccgctgtgt tcacctggcc cccctggcag gctggtatcc tggctcgtaa 15120 cctggtgccc atggtggcta ccgtgcaggg ccagaacctg aagtaccaag agttcttctg 15180 ggacgccaac gacatctacc gtatcttcgc tgagctggaa ggcgtgtggc agcccgctgc 15240 tcagcccaag cgtcgtcgtc accgtcagga cgctctgcct ggtccctgta tcgcttccac 15300 ccccaagaag caccgcggct aaaagcttgt cgagaagtac tagaggatca taatcagcca 15360 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 15420 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 15480 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 15540 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 15600 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta 15660 gctttgttta actttaagaa ggagatacat ctagacctgc aggccggaat attaatagat 15720 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 15780 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 15840 gggcgcggat cccggtccga agcgcgcgga attcgccacc atgaccatgg acgagcagca 15900 gccccaggct gtgacccccg tgtacgtggg cggtttcctg gctcgttacg accagtcccc 15960 cgacgaggct gagctgctgc tgccacgtga cgtggtcgaa cactggctgc acgctcaggg 16020 ccagggacag ccttccctgt ccgtggctct gcccctgaac atcaaccacg acgacaccgc 16080 tgtcgtgggt cacgtggccg ctatgcagtc cgtgcgtgac ggcctgttct gcctgggttg 16140 cgtgacctcc ccccgtttcc tggaaatcgt gcgtcgtgct tccgagaagt ccgagctggt 16200 gtcccgtggt cccgtgtccc cactgcagcc cgacaaggtg gtcgagttcc tgtccggttc 16260 ctacgctggc ctgtccctgt catcccgtcg ttgcgacgac gtcgaggctg ctacctccct 16320 gagcggctcc gagactaccc ccttcaagca cgtggccctg tgctccgtgg gtcgtaggcg 16380 tggaaccctg gctgtgtacg gtcgtgaccc cgagtgggtc acccagcgtt tccccgacct 16440 gaccgctgct gaccgtgacg gactgcgtgc tcagtggcag cgttgcggtt ccaccgctgt 16500 ggacgcttcc ggcgacccct tccgttccga ctcctacggc ctgctgggca actccgtgga 16560 cgctctgtac atccgcgagc gtctgcccaa gctgcgttac gacaagcagc tcgtgggtgt 16620 caccgagcgc gagtcctacg tgaaggcttc cgtgtccccc gaggctgctt gcgacatcaa 16680 ggctgcttcc gctgagcgtt ctggcgacag ccgctcccag gctgctactc ctgctgctgg 16740 tgctcgtgtg ccctccagct ccccatcccc acctgtcgag cctccctccc ccgtgcaacc 16800 tcctgctctg cctgcttccc cctccgtgct gcctgctgag tccagcccct ccctgtcacc 16860 ctctgagcct gctgaggctg cctccatgtc ccaccctctg agcgctgctg tgactgctgc 16920 taccgctccc cctggtgcta ctgtggctgg tgcttccccc gctgtgcctt ccctggcttg 16980 gcctcacgac ggtgtctacc tgcccaagga cgctttcttc tccctgctgg gcgcttcccg 17040 ttccgctgct cccgtgatgt accccggtgc tgtggctgct ccccccagcg cttcacctgc 17100 tcctctgccc ctgccctcct accccgcttc ctacggtgct cccgtcgtgg gttacgacca 17160 gctggctgct cgtcacttcg ctgactacgt ggacccccac taccccggct ggggtcgtcg 17220 ttacgagccc gctccttccc tgcacccatc ctaccctgtg ccccctcctc catcacccgc 17280 ttactaccgt cgtcgtgact cccccggtgg catggacgag cctccatctg gatgggagcg 17340 ttacgacggt tcccaccgtg gccagtccca aaagcagcac cgtcacggtg gttccggtgg 17400 tcacaacaag cgtcgcaagg aagccgctgc tgcatcctcc agctccgacg aggacctgag 17460 cttccccggc gaggctgaac acggtcgtgc tcgcaagcgt ctgaagtccc acgtgaactc 17520 cgacggaggt agcggaggcc acgctggttc caaccagcag cagcaacagc gctacgacga 17580 gctgcgtgac gctatccacg agctgaagcg tgacctgttc gctgctcgcc agtcctccac 17640 cctgctgtct gctgctctgc cagctgccgc ttcttcctcc cctaccacca ccaccgtgtg 17700 cacccctact ggcgagctga cctctggtgg tggcgagact cccaccgctc tgctgtccgg 17760 tggtgctaag gtggccgagc gtgctcaggc tggtgtcgtg aacgcttcct gccgtctggc 17820 taccgcttcc ggttccgagg ctgccaccgc tggtccctct accgctggtt cctcatcctg 17880 cccagcttcc gtggtgctgg ctgccgctgc tgctcaagcc gccgctgctt cacagtcccc 17940 cccaaaggat atggtggacc tgaaccgtcg tatcttcgtg gctgctctga acaagctcga 18000 gtaataaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 18060 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 18120 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 18180 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 18240 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 18300 ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag caataactat 18360 cataacccct aggggcctct aaacgggtct tgaggggttt tttgctgaaa ggaggaacta 18420 tatccggatc tgaacaggag ggacagctga tagaaacaga agccactgga gcacctcaaa 18480 aacaccatca tacactaaat cagtaagttg gcagcatcac ccgacgcact ttgcgccgaa 18540 taaatacctg tgacggaaga tcacttcgca gaataaataa atcctggtgt ccctgttgat 18600 accgggaagc cctgggccaa cttttggcga aaatgagacg ttgatcggca cgtaagaggt 18660 tccaactttc accataatga aataagatca ctaccgggcg tattttttga gttatcgaga 18720 ttttcaggag ctaaggaagc taaaatggag aaaaaaatca ctggatatac caccgttgat 18780 atatcccaat ggcatcgtaa agaacatttt gaggcatttc agtcagttgc tcaatgtacc 18840 tataaccaga ccgttcagct ggatattacg gcctttttaa agaccgtaaa gaaaaataag 18900 cacaagtttt atccggcctt tattcacatt cttgcccgcc tgatgaatgc tcatccggaa 18960 ttccgtatgg caatgaaaga cggtgagctg gtgatatggg atagtgttca cccttgttac 19020 accgttttcc atgagcaaac tgaaacgttt tcatcgctct ggagtgaata ccacgacgat 19080 ttccggcagt ttctacacat atattcgcaa gatgtggcgt gttacggtga aaacctggcc 19140 tatttcccta aagggtttat tgagaatatg tttttcgtct cagccaatcc ctgggtgagt 19200 ttcaccagtt ttgatttaaa cgtggccaat atggacaact tcttcgcccc cgttttcacc 19260 atgggcaaat attatacgca aggcgacaag gtgctgatgc cgctggcgat tcaggttcat 19320 catgccgttt gtgatggctt ccatgtcggc agaatgctta atgaattaca acagtactgc 19380 gatgagtggc agggcggggc gtaatttttt taaggcagtt attggtgccc ttaaacgcct 19440 ggttgctacg cctgaataag tgataataag cggatgaatg gcagaaattc gaaagcaaat 19500 tcgacccggt cgtcggttca gggcagggtc gttaaatagc cgcttatgtc tattgctggt 19560 ttaccggttt attgactacc ggaagcagtg tgaccgtgtg cttctcaaat gcctgaggcc 19620 agtttgctca ggctctcccc gtggaggtaa taattgacga tatgatcatt tattctgcct 19680 cccagctgac attcatccgg ggtcagcacc gtttctgcgg actggctttc tacgtgttcc 19740 gcttccttta gcagcccttg cgccctgagt gcttgcggca gcgtgaagct aattctgtca 19800 gccgttaagt gttcctgtgt cactcaaaat tgctttgaga ggctctaagg gcttctcagt 19860 gcgttacatc cctggcttgt tgtccacaac cgttaaacct taaaagcttt aaaagcctta 19920 tatattcttt tttttcttat aaaacttaaa accttagagg ctatttaagt tgctgattta 19980 tattaatttt attgttcaaa catgagagct tagtacgtga aacatgagag cttagtacgt 20040 tagccatgag agcttagtac gttagccatg agggtttagt tcgttaaaca tgagagctta 20100 gtacgttaaa catgagagct tagtacgtga aacatgagag cttagtacgt actatcaaca 20160 ggttgaactg ctgatcaaca gatcctctac gcggccgcgg taccataact tcgtatagca 20220 tacattatac gaagttatct ggtttaaacg tacccgtagt ggctatggca gggcttgccg 20280 ccccgacgtt ggctgcgagc cctgggcctt cacccgaact tgggggttgg ggtggggaaa 20340 aggaagaaac gcgggcgtat tggtcccaat ggggtctcgg tggggtatcg acagagtgcc 20400 agccctggga ccgaaccccg cgtttatgaa caaacgaccc aacacccgtg cgttttattc 20460 tgtcttttta ttgccgtcat agcgcgggtt ccttccggta ttgtctcctt ccgtgtttca 20520 gttagcctcc cccatctccc ggtaccgcat gctatgcatc agctgctagc ttagcgagcg 20580 tccacagcct ggggaccgta acgggagtga gcgggcaggt tcacacgggt ctgcttcagc 20640 tcagggggca ggccagcgta gtacttgtcc aggtgacgca gcaggggggg gtccagctgg 20700 tgacgcaggc agaattcctt cacagcgttg tacaggccgt agaacagggt gataccctcg 20760 ggagcagcag cggtggacac gggcagacgc acagcacggt tggtacgggt agcctcgtta 20820 cggatagcca ccaccacgtt gaacagggag gggggcacca gctcgaaacc cagcacgtgt 20880 tcggtgaaga tggaacgacc gtaggacaga cgagtcaggt cgtaaccacg gcacaggtcg 20940 tccacgcaag tgtacacagc gggggaaccg tcgccgcact cggagtaacc gcgcatcacg 21000 gtcatccaac ggggagcggt gtcggaggac agcagggtca gcagagcacg cagctggtcg 21060 gggttgttgt acagcagggc cagggtgtcc aggaaagcgt cgtccagcag cacggagtta 21120 gcagcctcgg gggtcacggg acggtaacgg atcagctggg acaggggacc gtccctacgg 21180 gtcacgttga ccaggggacg cagccaggac tcgtacttgt cgccctggaa cacctctccc 21240 agcaggcaac gacgggtcag ctcggggcac tcagcgggca ccttctcagc cacggtggga 21300 gccacggaca cggtagcgga ggacacgatg ggcagcagca ggcagcacca cagcagagcc 21360 acgggaccgg gggagaagga gaaaccgcag tcgggacgac ggcacatggt ggctcgagat 21420 cccgggtgat caagtcttcg tcgagtgatt gtaaataaaa tgtaatttac agtatagtat 21480 tttaattaat atacaaatga tttgataata attcttattt aactataata tattgtgttg 21540 ggttgaatta aaggtccgta tactagtatc gattcgcgac ctactccgga atattaatag 21600 atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc 21660 gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca 21720 tcgggcgcgg atccgccacc atgaactcca aggacctgac ccccttcctg accaccctgt 21780 ggctgctgct ggaccactcc cgtgtgcctc gtgtgcgtgc tgaggaatgc tgcgaagtga 21840 tcaacgtgaa ccaccccccc gagcgctgct acgacttcaa gatgtgcaac ctgttcaccg 21900 tggctctgcg ttgccccgac ggcgaagtgt gctactcccc cgaaaagacc gctgagatcc 21960 gtggtatcgt gaccaccatg acccactccc tgacccgtca agtgatccac aacaagctga 22020 ccagctgcaa ctacaacccc ctgtacctcg aggctgacgg tcgtatccgt tgcggcaagg 22080 tgtccgacaa ggctcagtac ctgctgggtg ctgctggttc cgtgccctac cgttggatca 22140 acctcgagta cgacaagatc acccgtatcg tgggcctgga ccagtacctc gagtccgtga 22200 agaagcacaa gcgtctggac gtgtgccgtg ctaagatggg ttacatgctg cagtaaaagc 22260 ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag gttttacttg 22320 ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg 22380 ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt 22440 tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg 22500 tatcttatca tgtctggatt gatcactgct tgagcctaga agatccggct gctaacaaag 22560 cccgaaagga agctgagttg gctgctgtgg ctagctttgt ttaactttaa gaaggagata 22620 catctagacc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 22680 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 22740 ggattattca taccgtccca ccatcgggcg cggatccgcc accatgctgc gtctgctgct 22800 gcgtcaccac ttccactgcc tgctgctgtg cgctgtgtgg gctaccccct gcctggcttc 22860 cccttggtcc accctgaccg ctaaccagaa cccctcccca ccctggtcca agctgaccta 22920 ctccaagccc cacgacgctg ctaccttcta ctgccccttc ctgtacccat ccccccctcg 22980 ttccccactg cagttctccg gtttccagcg tgtgctgacc ggtcccgagt gccgtaacga 23040 gactctgtac ctgctgtaca accgcgaggg ccagaccctg gtcgagaggt cctccacctg 23100 ggtcaagaag gtcatctggt acttgtccgg tcgtaaccag accatcctgc agcgtatgcc 23160 ccgtaccgct tccaagccct ccgacggcaa cgtgcagatc tccgtcgagg acgctaagat 23220 cttcggtgct cacatggtgc ccaagcagac caagctgctg cgtttcgtgg tcaacgacgg 23280 cacccgttac cagatgtgcg tgatgaagct cgagtcctgg gctcacgtgt tccgtgacta 23340 ctccgtgtcc ttccaagtgc gcctgacctt caccgaggct aacaaccaga cctacacctt 23400 ctgcacccac cccaacctga tcgtgtaaaa gcttgtcgag aagtactaga ggatcataat 23460 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 23520 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 23580 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 23640 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 23700 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 23760 ggtgcctaat gagtgagcta actcacatta attgcccgga atattaatag atcatggaga 23820 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 23880 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 23940 atccgccacc atgctgcgtc tgctgctgcg tcaccacttc cactgcctgc tgctgtgcgc 24000 tgtgtgggct accccctgcc tggcttcccc ctggttcacc ctgaccgcta accagaaccc 24060 ctccccaccc tggtccaagc tgacctaccc caagccccac gacgctgcta ccttctactg 24120 ccccttcctg tacccatccc cacctcgttc cccatcccag ttctccggtt tccagcgtgt 24180 gtccaccggt cccgagtgcc gtaacgagac tctgtacctg ctgtacaacc gcgagggcca 24240 gaccctggtc gagaggtcct ccacctgggt caagaaggtc atctggtact tgtccggtcg 24300 taaccagacc atcctgcagc gtatgccccg taccgcttcc aagccctccg acggcaacgt 24360 gcagatctcc gtcgaggacg ctaagatctt cggtgctcac atggtgccca agcagaccaa 24420 gctgctgcgt ttcgtggtca acgacggcac ccgttaccag atgtgcgtga tgaagctgga 24480 atcctgggct cacgtgttcc gtgactactc cgtgtccttc caagtgcgcc tgaccttcac 24540 cgaggctaac aaccagacct acaccttctg cacccacccc aacctgatcg tgtaagtcga 24600 caagcttgtc gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt 24660 acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat 24720 tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 24780 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 24840 caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta 24900 acaaagcccg aaaggaagct gagttggctg ctgggtgcct aatgagtgag ctaactcaca 24960 ttaattgccc ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa 25020 taaataagta ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc 25080 ggattattca taccgtccca ccatcgggcg cggatccgcc accggatccg ccaccatgcg 25140 tctgtgccgt gtgtggctgt ccgtgtgcct gtgcgctgtg gtgctgggac agtgccagcg 25200 tgaaaccgct gagaagaacg actactaccg tgtgccccac tactgggacg cttgctcccg 25260 tgctctgccc gaccagaccc gttacaagta cgtcgagcag ctggtggacc tgaccctgaa 25320 ctaccactac gacgcttccc acggcctgga caacttcgac gtgctgaagc gtatcaacgt 25380 gaccgaggtg tccctgctga tctccgactt ccgtcgtcag aaccgtcgtg gtggcaccaa 25440 caagcgtacc accttcaacg ctgctggttc cctggctccc cacgctcgtt ccttggagtt 25500 ctccgtgcgt ctgttcgcca actaataaaa gcttgtcgag aagtactaga ggatcataat 25560 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 25620 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 25680 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 25740 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 25800 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 25860 ccaccgctga gcaataacta tcataacccc cggaatatta atagatcatg gagataatta 25920 aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca gttttgtaat 25980 aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc gcggatcccg 26040 gtccgaagcg cgcggaattc aaaggcctac cgtcgacgcc accatggaat cccgtatctg 26100 gtgcctggtc gtgtgcgtga acctgtgcat cgtgtgcctg ggtgctgctg tgtcctcctc 26160 ctccacccgt ggcacctccg ctacccactc ccaccactcc tcccacacca cctccgccgc 26220 tcactcccgt tccggttccg tgtcccagcg tgtgacctcc tcccagaccg tgtcccacgg 26280 tgtcaacgag actatctaca acaccaccct gaagtacggc gacgtcgtgg gtgtcaacac 26340 caccaagtac ccctaccgtg tgtgctccat ggctcagggc accgacctga tccgtttcga 26400 gcgtaacatc gtgtgcacct ccatgaagcc catcaacgag gacctggacg agggtatcat 26460 ggtggtgtac aagcgcaaca tcgtggctca caccttcaag gtccgcgtgt accagaaggt 26520 gctgaccttc cgtcgttcct acgcttacat ccacaccact tacctgctgg gttccaacac 26580 cgagtacgtg gcccctccca tgtgggagat ccaccacatc aactcccact cccagtgcta 26640 ctcctcttac tcccgtgtga tcgctggcac cgtgttcgtg gcttaccacc gtgactccta 26700 cgagaacaag accatgcagc tgatgcccga cgactactcc aacacccact ccacccgtta 26760 cgtgaccgtg aaggaccagt ggcactcccg tggttccacc tggctgtacc gtgaaacctg 26820 caacctgaac tgcatggtca ccatcaccac cgctcgttcc aagtaccctt accacttctt 26880 cgctacctcc accggcgacg tggtggacat ctcccccttc tacaacggta ctaaccgtaa 26940 cgcttcctac ttcggcgaga acgctgacaa gttcttcatc ttccccaact acaccatcgt 27000 gtccgacttc ggtcgtccca actccgctct ggaaacccac cgtctggtgg ctttcttgga 27060 gcgtgctgac tccgtgatct cctgggacat ccaggacgag aagaacgtga cctgccagct 27120 gaccttctgg gaggcttccg agcgtaccat ccgttccgag gctgaggact cctaccactt 27180 ctccagcgct aagatgaccg ctaccttcct gtccaagaaa caagaggtca acatgtccga 27240 ctccgccctg gactgcgtgc gtgacgaggc tatcaacaag ctgcagcaga tcttcaacac 27300 ctcctacaac cagacctacg agaagtacgg aaacgtgtcc gtgttcgaga ctaccggtgg 27360 cctggtggtg ttctggcagg gtatcaagca gaagtccctg gtcgagctgg aacgtctggc 27420 taaccgttcc tccctgaacc tgacccacaa ccgtaccaag cgttccaccg acggcaacaa 27480 cgctactcac ctgtccaaca tggaatccgt gcacaacctg gtgtacgctc agctgcagtt 27540 cacctacgac accctgcgcg gttacatcaa ccgtgctctg gctcagatcg ctgaggcttg 27600 gtgcgtggac cagcgtcgta ccctggaagt gttcaaggaa ctgtccaaga tcaacccctc 27660 cgctatcctg tccgccatct acaacaagcc tatcgctgct cgtttcatgg gcgacgtgct 27720 gggcctggct tcctgcgtga ccatcaacca gacttccgtg aaggtgctgc gtgacatgaa 27780 cgtgaaggaa tcccccggtc gttgctactc ccgtcccgtg gtcatcttca acttcgctaa 27840 ctcctcctac gtgcagtacg gccagctggg cgaggacaac gagatcctgc tgggcaacca 27900 ccgtaccgag gaatgccagc tgccctccct gaagatcttc atcgctggca actccgctta 27960 cgaatacgtg gactacctgt tcaagcgcat gatcgacctg tcctccatct ctaccgtgga 28020 ctccatgatc gctctggaca tcgaccccct ggaaaacacc gacttccgtg tgctggaact 28080 gtactcccag aaggaactgc gttccatcaa cgtgttcgac ctggaagaga tcatgcgcga 28140 gttcaactcc tacaagcagc gtgttaagta cgtcgaggac aaggtggtgg accccctgcc 28200 cccctacctg aagggactgg acgacctgat gtccggcctg ggagctgccg gcaaggctgt 28260 gggtgtcgct atcggtgctg tgggtggtgc tgtggcttcc gtggtcgagg gtgtcgccac 28320 cttcctgaag aaccccttcg gtgctttcac catcatcctg gtggctatcg ctgtggtcat 28380 catcatctac ctgatctaca cccgtcagcg tcgtctgtgc atgcagcccc tgcagaacct 28440 gttcccctac ctggtgtccg ctgacggtac taccgtgacc tccggcaaca ccaaggacac 28500 ctccctgcag gctcccccat cctacgagga atccgtctac aactccggtc gcaagggtcc 28560 cggtccccct tcctccgacg cttctaccgc tgctccccca tacaccaacg agcaggctta 28620 ccagatgctg ctggctctcg tgcgtctgga cgctgagcag cgtgcacagc agaacggcac 28680 cgactccctg gacggccaga ccggaaccca ggacaagggc cagaagccca acctgctgga 28740 ccgtctgcgt caccgcaaga acggttaccg tcacctgaag gactccgacg aggaagagaa 28800 cgtctaaggc gcgccaagct tgtcgagaag tactagagat cataatcagc cataccacat 28860 ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata 28920 aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa 28980 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 29040 tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa 29100 gatccggctg ctaacaaagc ccgaaaggaa gctgggaata ttaatagatc atggagataa 29160 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 29220 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 29280 cgccaccatg cgtcccggcc tgccctccta cctgatcgtg ctggctgtgt gcctgctgtc 29340 ccacctcctg tcctcccgtt acggtgctga ggctatctcc gagcccctgg acaaggcttt 29400 ccacctcctg ctgaacacct acggtcgtcc tatccgtttc ctgcgcgaga acaccaccca 29460 gtgcacctac aactcctccc tgcgcaactc caccgtcgtc cgcgagaacg ctatctcctt 29520 caacttcttc cagtcctaca accagtacta cgtgttccac atgccccgtt gcctgttcgc 29580 tggtcccctg gctgagcagt tcctgaacca ggtggacctg accgagactc tcgagcgtta 29640 ccagcagcgt ctgaacactt acgctctggt gtccaaggac ctggcttcct accgttcctt 29700 cagccagcag ctgaaggctc aggactccct gggcgagcag cccaccactg tgcctccccc 29760 tatcgacctg tccatccccc acgtgtggat gcccccccag accactcctc acggctggac 29820 cgagtcccac accacctccg gactgcaccg tccccacttc aaccagacct gcatcctgtt 29880 cgacggtcac gacctgctgt tctccaccgt gaccccctgc ctgcaccagg gcttctacct 29940 catcgacgag ctgcgttacg tgaagatcac cctgaccgag gatttcttcg tggtcaccgt 30000 gtccatcgac gacgacaccc ccatgctgct gatcttcggt cacctccccc gtgtgctgtt 30060 caaggctccc taccagcgtg acaacttcat cctgcgtcag accgagaagc acgagctgct 30120 ggtgctggtc aagaaggacc agctgaaccg tcactcttac ctgaaggacc ccgacttcct 30180 ggacgctgct ctggacttca actacctgga cctgtccgct ctgctgagga actccttcca 30240 ccgttacgct gtggacgtgc tgaagtccgg tcgttgccag atgctggacc gtcgtaccgt 30300 cgagatggct ttcgcttacg ccctggctct gttcgctgct gctcgtcaag aagaggctgg 30360 cgctcaggtg tccgtgcccc gtgctctgga ccgtcaggct gctctgctgc agatccaaga 30420 gttcatgatc acttgcctgt cccagacccc ccctcgtacc accctgctgc tgtaccccac 30480 cgctgtggac ctggctaagc gtgctctgtg gacccccaac cagatcaccg acatcacctc 30540 cctcgtgcgt ctggtgtaca tcctgtccaa gcagaaccag cagcacctga tcccccagtg 30600 ggctctgcgt cagatcgctg acttcgctct gaagctgcac aagacccacc tggcttcatt 30660 cctcagcgct ttcgctcgcc aagagctgta cctgatgggt tccctggtgc actccatgct 30720 ggtgcacacc accgagcgtc gcgagatctt catcgtggaa accggcctgt gctccctggc 30780 cgagctgtcc cacttcaccc agctgctggc tcacccccac cacgagtacc tgtccgacct 30840 gtacaccccc tgctcctctt ccggtcgtcg tgaccactcc ctggaacgtc tgacccgtct 30900 gttccccgac gctaccgtgc ctaccaccgt gcctgctgct ctgtccatcc tgtctaccat 30960 gcagccctcc accctggaaa ccttccccga cctgttctgc ctgcctctgg gcgagtcctt 31020 ctccgctctg accgtgtccg agcacgtgtc ctacgtggtc accaaccagt acctgatcaa 31080 gggcatctcc taccccgtgt ccaccaccgt cgtgggccag tccctgatca tcacccagac 31140 cgactcccag accaagtgcg agctgacccg taacatgcac accactcact ccatcaccgc 31200 tgctctgaac atctccctcg agaactgcgc tttctgccag tccgctctgt tggagtacga 31260 cgacactcag ggtgtcatca acatcatgta catgcacgac tccgacgacg tgctgttcgc 31320 tctggacccc tacaacgagg tggtggtgtc ctccccccgt acccactacc tgatgctgct 31380 gaagaacggc accgtgctgg aagtgaccga cgtggtggtg gacgctaccg accgtctgct 31440 gatgatgtcc gtgtacgctc tgtccgctat catcggcatc tacctgctgt accgtatgct 31500 gaagacctgc taaggcgcca agctttgtcg agaagtacta gaggatcata atcagccata 31560 ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga 31620 aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca 31680 aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt 31740 gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc 31800 ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct 31860 gagcaataac tatcataacc cctaggagat ccgaaccaga taagtgaaat ctagttccaa 31920 actattttgt catttttaat tttcgtatta gcttacgacg ctacacccag ttcccatcta 31980 ttttgtcact cttccctaaa taatccttaa aaactccatt tccacccctc ccagttccca 32040 actattttgt ccgcccaca 32059 <210> 56 <211> 27327 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 56 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgcccaccgc tgagcaataa ctatcataac ccccggaata ttaatagatc atggagataa 7200 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 7260 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 7320 cgccaccatg gctgctatgg aagctaacat cttctgcacc ttcgaccaca agctgtctat 7380 cgctgacgtg ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc cccagcgtct 7440 gcacctgatc aagcactacc agctgggcct gcaccagttc gtggaccaca cccgtggtta 7500 cgtgcgtctg cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc gtgtcgaggg 7560 caaccagatc ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc tgaacaccgg 7620 tcccgtgacc tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt tccacggtcc 7680 cctggctcgt gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc cctggatcgt 7740 gcccatgccc ctggctctgg aaatcaacca gcgcctgctg atcatgggcc tgttctccct 7800 ggaccgttcc tacgaagaag tgaaggctgc tgtccagcag ctgcagacca tcaccttccg 7860 tgacgctacc ttcaccatcc ccgaccccgt gatcgaccag cacctcctga tcgacatgaa 7920 gaccgcttgc ctgtccatgt ccatggtggc taacctggct tccgagctga ccatgaccta 7980 cgtccgcaag ctggctttgg aggactcttc catgctgctg gtcaagtgcc aagagctgct 8040 gatgcgtctg gaccgcgagc gttccgtggg cgagcctcgt actcccgctc gtcctcagca 8100 cgtgtccccc gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc tgcgtcagct 8160 ggacgacctg atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc cagacaacaa 8220 gtccgctacc tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa gtactagagg 8280 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 8340 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 8400 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 8460 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 8520 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 8580 ggctgctgcc accgctgagc aataactatc ataacccccg gaatattaat agatcatgga 8640 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 8700 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 8760 ggatcccggt ccgaagcgcg cggaattcaa aggcctgcca ccatggaaat gaacaaggtg 8820 ctgcatcagg atctggtgca ggctacccgt cgtatcctga agctgggccc ctccgagctg 8880 cgtgtgaccg acgctggcct gatctgcaag aaccccaact actccgtgtg cgacgctatg 8940 ctcaagaccg acaccgtgta ctgcgtcgag tacctgctgt cctactggga gtcccgtacc 9000 gaccacgtgc cctgcttcat cttcaagaac accggttgcg ctgtgtccct gtgctgcttc 9060 gtgcgtgctc ccgtgaagct ggtgtcccct gctcgtcacg tgggcgagtt caacgtgctg 9120 aaggtcaacg agtccctgat cgtgaccctg aaggacatcg aggaaatcaa gccctccgct 9180 tacggtgtcc tgactaagtg cgtcgtccgc aagtccaact ccgcttccgt gttcaacatc 9240 gagctgatcg ctttcggtcc cgagaacgag ggcgagtacg agaacctgct gcgcgagctg 9300 tacgctaaga aggctgcttc cacctccctg gctgtgcgta accacgtgac cgtgtcctcc 9360 cactccggtt ccggtccctc cctgtggcgt gctcgtatgt ccgctgctct gacccgtacc 9420 gctggcaagc gctcctccag gactgctagc cctccaccac cacctcctcg tcaccctagc 9480 tgctctccca ctatggtggc tgctggtgga gctgctgctg gtcctagacc tccccctcct 9540 cctatggctg ctggatcctg gcgtctgtgc cgttgcgagg cttgcatggg ccgttgcggt 9600 tgcgcttccg agggcgacgc tgacgaggaa gaggaagagt tgctggctct ggctggcgag 9660 ggcaaggctg ctgctgccgc tgccggtcaa gacgtcggtg gttccgctcg tcgtcccctc 9720 gaggaacacg tgtcccgtcg tcgtggtgtc tccacccacc accgtcaccc cccttcccca 9780 ccttgcgctc cctccctgga acgtaccggt taccgttggg ctccttcctc ctggtggcgc 9840 gctcgttctg gtccttcccg tccccagtcc ggtccctggc tgcctgctcg tttcgctacc 9900 ctgggtcccc tggtcctggc tctgctgttg gtgctggccc tgctgtggcg tggtcacggt 9960 caatccccca gccccacccg ttccgctcac cgtgactaaa agcttgtcga gaagtactag 10020 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 10080 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 10140 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 10200 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 10260 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 10320 gttggctgct gtggctagct ttgtttaact ttaagaagga gatacatcta gaaatattaa 10380 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 10440 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 10500 ccatcgggcg cggatcccgg tccgaagcgc gcggaattca aaggcctacg tcgacgccac 10560 catgtccaac accgctcccg gtcccaccgt ggctaacaag cgtgacgaga agcaccgtca 10620 cgtggtcaac gtggtgctcg agctgcccac cgagatctcc gaggctaccc accccgtgct 10680 ggctaccatg ctgtccaagt acacccgtat gtcctccctg ttcaacgaca agtgcgcttt 10740 caagctggac ctgctgcgta tggtggctgt gtcccgtacc cgtcgctaaa agcttgtcga 10800 gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa 10860 aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa 10920 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 10980 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 11040 tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa 11100 aggaagctga gttggctgct gggtgcctaa tgagtgagct aactcacatt aattgcccgg 11160 aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt 11220 ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata 11280 ccgtcccacc atcgggcgcg gatcccggtc cgaagcgcgc ggaattcgcc accatggacg 11340 ctcgtgctgt ggctaagcgt ccccgtgacc ccgctgacga ggacaacgag ctggtcaccg 11400 ctctgaaggc taagcgtgaa gtgaacacca tctccgtgcg ttacctgtac cacgctgacc 11460 accaggctct gaccgctcgt ttcttcgtgc ccgagggcct ggtcgagttc gaggctcagc 11520 ccggtgctct gctgatccgt atggaaaccg gttgcgactc cccccgtcac ctgtacatct 11580 ccctgtacct gctgggtatc cgtgcttcca acgtgtccgc ttccacccgt tgcctgctcg 11640 agtccgtgta caccgcttcc gctgctcgtg ctgctctgca gtggctggac ctgggtcccc 11700 acctcctgca ccgtcgtctg gaaaccctgg gttgcgtcaa gaccgtgtcc ctgggtatca 11760 cctccctgct gacctgcgtg atgcgcggct acctgtacaa caccctcaag accgaggtgt 11820 tcgctctgat gatccccaag gacatgtacc tgacctggga ggaaacccgc ggtcgtctgc 11880 agtacgtgta cctgatcatc gtgtacgact acgacggtcc cgagactcgt cccggtatct 11940 acgtgctgac ctcctctatc gctcactggc agaccctggt ggacgtggcc cgtggaaagt 12000 tcgctcgtga acgctgctcc ttcgtgaacc gtcgtatcac ccgtccccgt cagatccccc 12060 tgtgcaccgg tgtcatccaa aagctgggct ggtgcctggc tgacgacatc cacacctcat 12120 tcctcgtgca caaggaactg aagctgtccg tcgtgcgtct ggacaacttc tccgtcgagc 12180 tgggcgactt ccgcgagttc gtgtaaaagc ttgtcgagaa gtactagagg atcataatca 12240 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 12300 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 12360 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 12420 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 12480 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc 12540 accgctgagc aataactatc ataaccccta ggggcctcta aacgggtctt gaggggtttt 12600 ttgctgaaag gaggaactat atccggatct gaacaggagg gacagctgat agaaacagaa 12660 gccactggag cacctcaaaa acaccatcat acactaaatc agtaagttgg cagcatcacc 12720 cgacgcactt tgcgccgaat aaatacctgt gacggaagat cacttcgcag aataaataaa 12780 tcctggtgtc cctgttgata ccgggaagcc ctgggccaac ttttggcgaa aatgagacgt 12840 tgatcggcac gtaagaggtt ccaactttca ccataatgaa ataagatcac taccgggcgt 12900 attttttgag ttatcgagat tttcaggagc taaggaagct aaaatggaga aaaaaatcac 12960 tggatatacc accgttgata tatcccaatg gcatcgtaaa gaacattttg aggcatttca 13020 gtcagttgct caatgtacct ataaccagac cgttcagctg gatattacgg cctttttaaa 13080 gaccgtaaag aaaaataagc acaagtttta tccggccttt attcacattc ttgcccgcct 13140 gatgaatgct catccggaat tccgtatggc aatgaaagac ggtgagctgg tgatatggga 13200 tagtgttcac ccttgttaca ccgttttcca tgagcaaact gaaacgtttt catcgctctg 13260 gagtgaatac cacgacgatt tccggcagtt tctacacata tattcgcaag atgtggcgtg 13320 ttacggtgaa aacctggcct atttccctaa agggtttatt gagaatatgt ttttcgtctc 13380 agccaatccc tgggtgagtt tcaccagttt tgatttaaac gtggccaata tggacaactt 13440 cttcgccccc gttttcacca tgggcaaata ttatacgcaa ggcgacaagg tgctgatgcc 13500 gctggcgatt caggttcatc atgccgtttg tgatggcttc catgtcggca gaatgcttaa 13560 tgaattacaa cagtactgcg atgagtggca gggcggggcg taattttttt aaggcagtta 13620 ttggtgccct taaacgcctg gttgctacgc ctgaataagt gataataagc ggatgaatgg 13680 cagaaattcg aaagcaaatt cgacccggtc gtcggttcag ggcagggtcg ttaaatagcc 13740 gcttatgtct attgctggtt taccggttta ttgactaccg gaagcagtgt gaccgtgtgc 13800 ttctcaaatg cctgaggcca gtttgctcag gctctccccg tggaggtaat aattgacgat 13860 atgatcattt attctgcctc ccagctgaca ttcatccggg gtcagcaccg tttctgcgga 13920 ctggctttct acgtgttccg cttcctttag cagcccttgc gccctgagtg cttgcggcag 13980 cgtgaagcta attctgtcag ccgttaagtg ttcctgtgtc actcaaaatt gctttgagag 14040 gctctaaggg cttctcagtg cgttacatcc ctggcttgtt gtccacaacc gttaaacctt 14100 aaaagcttta aaagccttat atattctttt ttttcttata aaacttaaaa ccttagaggc 14160 tatttaagtt gctgatttat attaatttta ttgttcaaac atgagagctt agtacgtgaa 14220 acatgagagc ttagtacgtt agccatgaga gcttagtacg ttagccatga gggtttagtt 14280 cgttaaacat gagagcttag tacgttaaac atgagagctt agtacgtgaa acatgagagc 14340 ttagtacgta ctatcaacag gttgaactgc tgatcaacag atcctctacg cggccgcggt 14400 accataactt cgtatagcat acattatacg aagttatctg gtttaaacgt acccgtagtg 14460 gctatggcag ggcttgccgc cccgacgttg gctgcgagcc ctgggccttc acccgaactt 14520 gggggttggg gtggggaaaa ggaagaaacg cgggcgtatt ggtcccaatg gggtctcggt 14580 ggggtatcga cagagtgcca gccctgggac cgaaccccgc gtttatgaac aaacgaccca 14640 acacccgtgc gttttattct gtctttttat tgccgtcata gcgcgggttc cttccggtat 14700 tgtctccttc cgtgtttcag ttagcctccc ccatctcccg gtaccgcatg ctatgcatca 14760 gctgctagct tagcgagcgt ccacagcctg gggaccgtaa cgggagtgag cgggcaggtt 14820 cacacgggtc tgcttcagct cagggggcag gccagcgtag tacttgtcca ggtgacgcag 14880 cagggggggg tccagctggt gacgcaggca gaattccttc acagcgttgt acaggccgta 14940 gaacagggtg ataccctcgg gagcagcagc ggtggacacg ggcagacgca cagcacggtt 15000 ggtacgggta gcctcgttac ggatagccac caccacgttg aacagggagg ggggcaccag 15060 ctcgaaaccc agcacgtgtt cggtgaagat ggaacgaccg taggacagac gagtcaggtc 15120 gtaaccacgg cacaggtcgt ccacgcaagt gtacacagcg ggggaaccgt cgccgcactc 15180 ggagtaaccg cgcatcacgg tcatccaacg gggagcggtg tcggaggaca gcagggtcag 15240 cagagcacgc agctggtcgg ggttgttgta cagcagggcc agggtgtcca ggaaagcgtc 15300 gtccagcagc acggagttag cagcctcggg ggtcacggga cggtaacgga tcagctggga 15360 caggggaccg tccctacggg tcacgttgac caggggacgc agccaggact cgtacttgtc 15420 gccctggaac acctctccca gcaggcaacg acgggtcagc tcggggcact cagcgggcac 15480 cttctcagcc acggtgggag ccacggacac ggtagcggag gacacgatgg gcagcagcag 15540 gcagcaccac agcagagcca cgggaccggg ggagaaggag aaaccgcagt cgggacgacg 15600 gcacatggtg gctcgagatc ccgggtgatc aagtcttcgt cgagtgattg taaataaaat 15660 gtaatttaca gtatagtatt ttaattaata tacaaatgat ttgataataa ttcttattta 15720 actataatat attgtgttgg gttgaattaa aggtccgtat actagtatcg attcgcgacc 15780 tactccggaa tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa 15840 taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat 15900 tattcatacc gtcccaccat cgggcgcgga tccgccacca tgtcccccaa gaacctgacc 15960 cccttcctga ccgctctgtg gctgctgctg ggccactccc gtgtgcctcg tgtgcgtgct 16020 gaggaatgct gcgagttcat caacgtgaac cacccccccg agcgctgcta cgacttcaag 16080 atgtgcaacc gtttcaccgt ggctctgcgt tgccccgacg gcgaagtgtg ctactccccc 16140 gaaaagaccg ctgagatccg tggtatcgtg accaccatga cccactccct gacccgtcag 16200 gtggtgcaca acaagctgac ctcttgcaac tacaaccccc tgtacctcga ggctgacggt 16260 cgtatccgtt gcggcaaggt caacgacaag gctcagtacc tgctgggtgc tgctggttcc 16320 gtgccctacc gttggatcaa cctcgagtac gacaagatca cccgtatcgt gggcctggac 16380 cagtacctcg agtccgtgaa gaagcacaag cgtctggacg tgtgccgtgc taagatgggt 16440 tacatgctgc agtaaaagct tgtcgagaag tactagagga tcataatcag ccataccaca 16500 tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat 16560 aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa 16620 agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt 16680 ttgtccaaac tcatcaatgt atcttatcat gtctggatct gatcactgct tgagcctaga 16740 agatccggct gctaacaaag cccgaaagga agctgagttg gctgctgtgg ctagctttgt 16800 ttaactttaa gaaggagata catctagacc ggaatattaa tagatcatgg agataattaa 16860 aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag ttttgtaata 16920 aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg cggatccgcc 16980 accatgctgc gtctgctgct gcgtcaccac ttccactgcc tgctgctgtg cgctgtgtgg 17040 gctaccccct gcctggcttc cccttggtcc accctgaccg ctaaccagaa cccctcccca 17100 ccctggtcca agctgaccta ctccaagccc cacgacgctg ctaccttcta ctgccccttc 17160 ctgtacccat ccccccctcg ttccccactg cagttctccg gtttccagcg tgtgctgacc 17220 ggtcccgagt gccgtaacga gactctgtac ctgctgtaca accgcgaggg ccagaccctg 17280 gtcgagaggt cctccacctg ggtcaagaag gtcatctggt acttgtccgg tcgtaaccag 17340 accatcctgc agcgtatgcc ccgtaccgct tccaagccct ccgacggcaa cgtgcagatc 17400 tccgtcgagg acgctaagat cttcggtgct cacatggtgc ccaagcagac caagctgctg 17460 cgtttcgtgg tcaacgacgg cacccgttac cagatgtgcg tgatgaagct cgagtcctgg 17520 gctcacgtgt tccgtgacta ctccgtgtcc ttccaagtgc gcctgacctt caccgaggct 17580 aacaaccaga cctacacctt ctgcacccac cccaacctga tcgtgtaaaa gcttgtcgag 17640 aagtactaga ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa 17700 aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac 17760 ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 17820 aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat 17880 catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca aagcccgaaa 17940 ggaagctgag ttggctgctg ggtgcctaat gagtgagcta actcacatta attgcccgga 18000 atattaatag atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt 18060 tactgttttc gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac 18120 cgtcccacca tcgggcgcgg atccgccacc atgcgtctgt gccgtgtgtg gctgtccgtg 18180 tgcctgtgcg ctgtggtgct gggccagtgc cagcgtgaaa ccgctgagaa gaacgactac 18240 taccgtgtgc cccactactg ggacgcttgc tcccgtgctc tgcccgacca gacccgttac 18300 aagtacgtcg agcagctggt ggacctgacc ctgaactacc actacgacgc ttcccacggc 18360 ctggacaact tcgacgtgct gaagcgtatc aacgtgaccg aggtgtccct gctgatctcc 18420 gacttccgtc gtcagaaccg tcgtggtggc accaacaagc gtaccacctt caacgctgct 18480 ggttccctgg ctccccacgc tcgttccctc gagttctccg tgcgtctgtt cgctaactaa 18540 aagcttgtcg agaagtacta gaggatcata atcagccata ccacatttgt agaggtttta 18600 cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 18660 gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 18720 aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 18780 aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctagaagatc cggctgctaa 18840 caaagcccga aaggaagctg agttggctgc tgccaccgct gagcaataac tatcataacc 18900 cccggaatat taatagatca tggagataat taaaatgata accatctcgc aaataaataa 18960 gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat tccggattat 19020 tcataccgtc ccaccatcgg gcgcggatcc cggtccgaag cgcgcggaat tcaaaggcct 19080 accgtcgacg ccaccatgga atcccgtatc tggtgcctgg tcgtgtgcgt gaacctgtgc 19140 atcgtgtgcc tgggtgctgc tgtgtcctcc tcctccaccc gtggcacctc cgctacccac 19200 tcccaccact cctcccacac cacctccgcc gctcactccc gttccggttc cgtgtcccag 19260 cgtgtgacct cctcccagac cgtgtcccac ggtgtcaacg agactatcta caacaccacc 19320 ctgaagtacg gcgacgtcgt gggtgtcaac accaccaagt acccctaccg tgtgtgctcc 19380 atggctcagg gcaccgacct gatccgtttc gagcgtaaca tcgtgtgcac ctccatgaag 19440 cccatcaacg aggacctgga cgagggtatc atggtggtgt acaagcgcaa catcgtggct 19500 cacaccttca aggtccgcgt gtaccagaag gtgctgacct tccgtcgttc ctacgcttac 19560 atccacacca cttacctgct gggttccaac accgagtacg tggcccctcc catgtgggag 19620 atccaccaca tcaactccca ctcccagtgc tactcctctt actcccgtgt gatcgctggc 19680 accgtgttcg tggcttacca ccgtgactcc tacgagaaca agaccatgca gctgatgccc 19740 gacgactact ccaacaccca ctccacccgt tacgtgaccg tgaaggacca gtggcactcc 19800 cgtggttcca cctggctgta ccgtgaaacc tgcaacctga actgcatggt caccatcacc 19860 accgctcgtt ccaagtaccc ttaccacttc ttcgctacct ccaccggcga cgtggtggac 19920 atctccccct tctacaacgg tactaaccgt aacgcttcct acttcggcga gaacgctgac 19980 aagttcttca tcttccccaa ctacaccatc gtgtccgact tcggtcgtcc caactccgct 20040 ctggaaaccc accgtctggt ggctttcttg gagcgtgctg actccgtgat ctcctgggac 20100 atccaggacg agaagaacgt gacctgccag ctgaccttct gggaggcttc cgagcgtacc 20160 atccgttccg aggctgagga ctcctaccac ttctccagcg ctaagatgac cgctaccttc 20220 ctgtccaaga aacaagaggt caacatgtcc gactccgccc tggactgcgt gcgtgacgag 20280 gctatcaaca agctgcagca gatcttcaac acctcctaca accagaccta cgagaagtac 20340 ggaaacgtgt ccgtgttcga gactaccggt ggcctggtgg tgttctggca gggtatcaag 20400 cagaagtccc tggtcgagct ggaacgtctg gctaaccgtt cctccctgaa cctgacccac 20460 aaccgtacca agcgttccac cgacggcaac aacgctactc acctgtccaa catggaatcc 20520 gtgcacaacc tggtgtacgc tcagctgcag ttcacctacg acaccctgcg cggttacatc 20580 aaccgtgctc tggctcagat cgctgaggct tggtgcgtgg accagcgtcg taccctggaa 20640 gtgttcaagg aactgtccaa gatcaacccc tccgctatcc tgtccgccat ctacaacaag 20700 cctatcgctg ctcgtttcat gggcgacgtg ctgggcctgg cttcctgcgt gaccatcaac 20760 cagacttccg tgaaggtgct gcgtgacatg aacgtgaagg aatcccccgg tcgttgctac 20820 tcccgtcccg tggtcatctt caacttcgct aactcctcct acgtgcagta cggccagctg 20880 ggcgaggaca acgagatcct gctgggcaac caccgtaccg aggaatgcca gctgccctcc 20940 ctgaagatct tcatcgctgg caactccgct tacgaatacg tggactacct gttcaagcgc 21000 atgatcgacc tgtcctccat ctctaccgtg gactccatga tcgctctgga catcgacccc 21060 ctggaaaaca ccgacttccg tgtgctggaa ctgtactccc agaaggaact gcgttccatc 21120 aacgtgttcg acctggaaga gatcatgcgc gagttcaact cctacaagca gcgtgttaag 21180 tacgtcgagg acaaggtggt ggaccccctg cccccctacc tgaagggact ggacgacctg 21240 atgtccggcc tgggagctgc cggcaaggct gtgggtgtcg ctatcggtgc tgtgggtggt 21300 gctgtggctt ccgtggtcga gggtgtcgcc accttcctga agaacccctt cggtgctttc 21360 accatcatcc tggtggctat cgctgtggtc atcatcatct acctgatcta cacccgtcag 21420 cgtcgtctgt gcatgcagcc cctgcagaac ctgttcccct acctggtgtc cgctgacggt 21480 actaccgtga cctccggcaa caccaaggac acctccctgc aggctccccc atcctacgag 21540 gaatccgtct acaactccgg tcgcaagggt cccggtcccc cttcctccga cgcttctacc 21600 gctgctcccc catacaccaa cgagcaggct taccagatgc tgctggctct cgtgcgtctg 21660 gacgctgagc agcgtgcaca gcagaacggc accgactccc tggacggcca gaccggaacc 21720 caggacaagg gccagaagcc caacctgctg gaccgtctgc gtcaccgcaa gaacggttac 21780 cgtcacctga aggactccga cgaggaagag aacgtctaag gcgcgccaag cttgtcgaga 21840 agtactagag atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa 21900 cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt 21960 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 22020 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 22080 tgtctggatc tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg 22140 aagctgggaa tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa 22200 taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat 22260 tattcatacc gtcccaccat cgggcgcgga tccgccacca tgcgtcccgg cctgccctcc 22320 tacctgatcg tgctggctgt gtgcctgctg tcccacctcc tgtcctcccg ttacggtgct 22380 gaggctatct ccgagcccct ggacaaggct ttccacctcc tgctgaacac ctacggtcgt 22440 cctatccgtt tcctgcgcga gaacaccacc cagtgcacct acaactcctc cctgcgcaac 22500 tccaccgtcg tccgcgagaa cgctatctcc ttcaacttct tccagtccta caaccagtac 22560 tacgtgttcc acatgccccg ttgcctgttc gctggtcccc tggctgagca gttcctgaac 22620 caggtggacc tgaccgagac tctcgagcgt taccagcagc gtctgaacac ttacgctctg 22680 gtgtccaagg acctggcttc ctaccgttcc ttcagccagc agctgaaggc tcaggactcc 22740 ctgggcgagc agcccaccac tgtgcctccc cctatcgacc tgtccatccc ccacgtgtgg 22800 atgccccccc agaccactcc tcacggctgg accgagtccc acaccacctc cggactgcac 22860 cgtccccact tcaaccagac ctgcatcctg ttcgacggtc acgacctgct gttctccacc 22920 gtgaccccct gcctgcacca gggcttctac ctcatcgacg agctgcgtta cgtgaagatc 22980 accctgaccg aggatttctt cgtggtcacc gtgtccatcg acgacgacac ccccatgctg 23040 ctgatcttcg gtcacctccc ccgtgtgctg ttcaaggctc cctaccagcg tgacaacttc 23100 atcctgcgtc agaccgagaa gcacgagctg ctggtgctgg tcaagaagga ccagctgaac 23160 cgtcactctt acctgaagga ccccgacttc ctggacgctg ctctggactt caactacctg 23220 gacctgtccg ctctgctgag gaactccttc caccgttacg ctgtggacgt gctgaagtcc 23280 ggtcgttgcc agatgctgga ccgtcgtacc gtcgagatgg ctttcgctta cgccctggct 23340 ctgttcgctg ctgctcgtca agaagaggct ggcgctcagg tgtccgtgcc ccgtgctctg 23400 gaccgtcagg ctgctctgct gcagatccaa gagttcatga tcacttgcct gtcccagacc 23460 ccccctcgta ccaccctgct gctgtacccc accgctgtgg acctggctaa gcgtgctctg 23520 tggaccccca accagatcac cgacatcacc tccctcgtgc gtctggtgta catcctgtcc 23580 aagcagaacc agcagcacct gatcccccag tgggctctgc gtcagatcgc tgacttcgct 23640 ctgaagctgc acaagaccca cctggcttca ttcctcagcg ctttcgctcg ccaagagctg 23700 tacctgatgg gttccctggt gcactccatg ctggtgcaca ccaccgagcg tcgcgagatc 23760 ttcatcgtgg aaaccggcct gtgctccctg gccgagctgt cccacttcac ccagctgctg 23820 gctcaccccc accacgagta cctgtccgac ctgtacaccc cctgctcctc ttccggtcgt 23880 cgtgaccact ccctggaacg tctgacccgt ctgttccccg acgctaccgt gcctaccacc 23940 gtgcctgctg ctctgtccat cctgtctacc atgcagccct ccaccctgga aaccttcccc 24000 gacctgttct gcctgcctct gggcgagtcc ttctccgctc tgaccgtgtc cgagcacgtg 24060 tcctacgtgg tcaccaacca gtacctgatc aagggcatct cctaccccgt gtccaccacc 24120 gtcgtgggcc agtccctgat catcacccag accgactccc agaccaagtg cgagctgacc 24180 cgtaacatgc acaccactca ctccatcacc gctgctctga acatctccct cgagaactgc 24240 gctttctgcc agtccgctct gttggagtac gacgacactc agggtgtcat caacatcatg 24300 tacatgcacg actccgacga cgtgctgttc gctctggacc cctacaacga ggtggtggtg 24360 tcctcccccc gtacccacta cctgatgctg ctgaagaacg gcaccgtgct ggaagtgacc 24420 gacgtggtgg tggacgctac cgaccgtctg ctgatgatgt ccgtgtacgc tctgtccgct 24480 atcatcggca tctacctgct gtaccgtatg ctgaagacct gctaaggcgc caagctttgt 24540 cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt 24600 aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt 24660 taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 24720 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 24780 ttatcatgtc tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc 24840 gaaaggaagc tgagttggct gctgctgagt agtgcgcgag caaaatttaa gctacaacaa 24900 ggcacgcgtc cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa 24960 ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc 25020 cggattattc ataccgtccc accatcgggc gcggatcccg gtccgaagcg cgcggaattc 25080 aaaggcctac gtcgacgcca ccatggaatc ccgtggtcgt cgttgccccg agatgatctc 25140 cgtgctgggt cccatctccg gtcacgtcct gaaggctgtg ttctcccgtg gcgacacccc 25200 cgtgctgccc cacgaaactc gtctgctgca gaccggtatc cacgtgcgtg tgtcccagcc 25260 ctccctgatc ctggtgtccc agtacacccc cgactccacc ccttgccacc gcggagacaa 25320 ccagctgcag gtccagcaca cctacttcac cggttccgag gtcgagaacg tgtccgtgaa 25380 cgtgcacaac cccaccggtc gttccatctg cccctcccaa gagcccatgt ccatctacgt 25440 gtacgctctg cccctgaaga tgctgaacat cccctccatc aacgtgcacc actacccctc 25500 cgctgctgag cgcaagcacc gtcacctccc cgtggctgac gctgtgatcc acgcttccgg 25560 caagcagatg tggcaggctc gtctgaccgt gtccggcctg gcttggaccc gtcagcagaa 25620 ccagtggaag gaacccgacg tgtactacac ctccgctttc gtgttcccca ccaaggacgt 25680 ggccctgcgt cacgtcgtgt gcgctcacga actcgtgtgc tccatggaaa acacccgtgc 25740 taccaagatg caagtgatcg gcgaccagta cgtgaaggtg tacctggaat ccttctgcga 25800 ggacgtgccc tccggcaagc tgttcatgca cgtgaccctg ggttccgacg tggaagagga 25860 cctgaccatg acccgtaacc cccagccctt catgcgtccc cacgagcgta acggtttcac 25920 cgtgctgtgc cccaagaaca tgatcatcaa gcccggcaag atctcccaca tcatgctgga 25980 cgtggccttc acctcccacg agcacttcgg cctgctgtgc cctaagtcca tccccggcct 26040 gtccatctcc ggcaacctgc tgatgaacgg ccagcagatc ttcctggaag tgcaggctat 26100 ccgtgaaacc gtcgagctgc gtcagtacga ccctgtggct gctctgttct tcttcgacat 26160 cgacctgctg ctgcagcgtg gtccccagta ctccgagcac cccaccttca ccagccagta 26220 ccgtatccag ggcaagctgg aataccgtca cacctgggac cgtcacgacg agggtgctgc 26280 tcagggcgac gacgacgtgt ggacctccgg ttccgactcc gacgaggaac tggtcaccac 26340 cgagcgcaag accccccgtg tgaccggtgg tggtgctatg gctggtgctt ccacctccgc 26400 tggtcgcaag cgcaagtccg cttcctccgc taccgcttgc accgctggtg tcatgacccg 26460 tggtcgcctg aaggctgagt ccaccgtggc tcccgaagag gacactgacg aggactccga 26520 caacgagatc cacaaccccg ctgtgttcac ctggcccccc tggcaggctg gtatcctggc 26580 tcgtaacctg gtgcccatgg tggctaccgt gcagggccag aacctgaagt accaagagtt 26640 cttctgggac gccaacgaca tctaccgtat cttcgctgag ctggaaggcg tgtggcagcc 26700 cgctgctcag cccaagcgtc gtcgtcaccg tcaggacgct ctgcctggtc cctgtatcgc 26760 ttccaccccc aagaagcacc gcggctaaaa gcttgtcgag aagtactaga ggatcataat 26820 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 26880 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 26940 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 27000 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 27060 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 27120 ccaccgctga gcaataacta tcataacccc taggagatcc gaaccagata agtgaaatct 27180 agttccaaac tattttgtca tttttaattt tcgtattagc ttacgacgct acacccagtt 27240 cccatctatt ttgtcactct tccctaaata atccttaaaa actccatttc cacccctccc 27300 agttcccaac tattttgtcc gcccaca 27327 <210> 57 <211> 26483 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 57 ttaggtggcg gtacttgggt cgatatcaaa gtgcatcact tcttcccgta tgcccaactt 60 tgtatagaga gccactgcgg gatcgtcacc gtaatctgct tgcacgtaga tcacataagc 120 accaagcgcg ttggcctcat gcttgaggag attgatgagc gcggtggcaa tgccctgcct 180 ccggtgctcg ccggagactg cgagatcata gatatagatc tcactacgcg gctgctcaaa 240 cttgggcaga acgtaagccg cgagagcgcc aacaaccgct tcttggtcga aggcagcaag 300 cgcgatgaat gtcttactac ggagcaagtt cccgaggtaa tcggagtccg gctgatgttg 360 ggagtaggtg gctacgtctc cgaactcacg accgaaaaga tcaagagcag cccgcatgga 420 tttgacttgg tcagggccga gcctacatgt gcgaatgatg cccatacttg agccacctaa 480 ctttgtttta gggcgactgc cctgctgcgt aacatcgttg ctgctgcgta acatcgttgc 540 tgctccataa catcaaacat cgacccacgg cgtaacgcgc ttgctgcttg gatgcccgag 600 gcatagactg tacaaaaaaa cagtcataac aagccatgaa aaccgccact gcgccgttac 660 caccgctgcg ttcggtcaag gttctggacc agttgcgtga gcgcatacgc tacttgcatt 720 acagtttacg aaccgaacag gcttatgtca actgggtttg tgccttcatc cgtttccacg 780 gtgtgcgtca cccggcaacc ttgggcagca gcgaagtcga ggcatttctg tcctggctgg 840 cgaacgagcg caaggtttcg gtctccacgc atcgtcaggc attggcggcc ttgctgttct 900 tctacggcaa ggtgctgtgc acggatctgc ccttgcttca ggagatcggt agacctcggc 960 cgtcgcggcg cttgccggtg gtgctgaccc cggatgaagt ggttcgcatc ctcggttttc 1020 tggaaggcga gcatcgtttg ttcgcccagg actctagcta tagttctagt ggttggctac 1080 agctttgttt gtactatcaa caggttgaac tgctgatcaa cagatcctct acgcggccgc 1140 ggtaccataa cttcgtatag catacattat acgaagttat ctggtttaaa cgtacccgta 1200 gtggctatgg cagggcttgc cgccccgacg ttggctgcga gccctgggcc ttcacccgaa 1260 cttgggggtt ggggtgggga aaaggaagaa acgcgggcgt attggtccca atggggtctc 1320 ggtggggtat cgacagagtg ccagccctgg gaccgaaccc cgcgtttatg aacaaacgac 1380 ccaacacccg tgcgttttat tctgtctttt tattgccgtc atagcgcggg ttccttccgg 1440 tattgtctcc ttccgtgttt cagttagcct cccccatctc ccggtaccgc atgctatgca 1500 tcagctgcta gcaccatggc tcgagatccc gggtgatcaa gtcttcgtcg agtgattgta 1560 aataaaatgt aatttacagt atagtatttt aattaatata caaatgattt gataataatt 1620 cttatttaac tataatatat tgtgttgggt tgaattaaag gtccgtatac tagtatcgat 1680 tcgcgaccta ctccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg 1740 caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata 1800 ttccggatta ttcataccgt cccaccatcg ggcgcggatc cgccaccatg gaaaactggt 1860 ccgctctgga actgctgccc aaggtcggaa tccctaccga cttcctgacc cacgtcaaga 1920 cctccgctgg cgaggaaatg ttcgaggctc tgaggatcta ctacggcgac gaccccgagc 1980 gttacaacat ccacttcgag gctatcttcg gcaccttctg caaccgtctg gaatgggtgt 2040 acttcctgac ttccggcctg gctgctgctg ctcacgctat caagttccac gacctgaaca 2100 agctgaccac cggcaagatg ctgttccacg tgcaagtgcc ccgtgtggct tccggtgctg 2160 gcctgcctac ctcccgtcag accaccatca tggtcaccaa gtactccgag aagtccccca 2220 tcaccatccc tttcgagctg tccgctgctt gcctgactta cctgcgtgaa accttcgagg 2280 gcaccatcct ggacaagatc ctgaacgtcg aggctatgca caccgtgctg cgtgctctga 2340 agaacaccgc tgacgctatg gaacgtggcc tgatccacag cttcctccag accctgctga 2400 ggaaggctcc cccctacttc gtggtgcaga ccctggtcga gaacgctacc ctggctcgtc 2460 aggctctgaa ccgtatccag cgctccaaca tcctgcagtc cttcaaggct aagatgctgg 2520 ctaccctgtt cctgctgaac cgtacccgtg accgtgacta cgtgctgaag ttcctgaccc 2580 gtctggctga ggctgctacc gactccatcc tcgacaaccc tactacctac accacctcct 2640 ccggtgctaa gatctccggt gtcatggtgt ccaccgctaa cgtgatgcag atcatcatgt 2700 ccctgctgtc ctcccacatc actaaggaaa ccgtgtccgc tcccgctacc tacggcaact 2760 tcgtgctgtc ccccgagaac gctgtgaccg ctatctccta ccactctatc ctggctgact 2820 tcaactccta caaggctcac ctgacctccg gccagcccca cctccccaac gactccctga 2880 gccaggctgg tgctcactcc ctgacccccc tgtccatgga cgtgatccgt ctgggcgaaa 2940 agaccgtgat catggaaaac ctgcgtcgcg tgtacaagaa caccgacacc aaggaccccc 3000 tggaacgtaa cgtggacctg accttcttct tccccgtggg cctgtacctg cccgaggacc 3060 gtggttacac caccgtcgag tccaaggtca agctgaacga caccgtgcgt aacgctctgc 3120 ccaccaccgc ttacctgctg aacagggacc gtgctgtgca aaagatcgac ttcgtggacg 3180 ctctcaagac cctgtgccac cccgtgctgc acgagcctgc tccatgcctg caggctttca 3240 ccgagcgtgg tcccccatcc gagcccgcta tgcagcgtct gctggaatgc cgtttccagc 3300 aagagcccat gggtggtgct gctcgtcgta tcccccactt ctaccgtgtg cgccgcgagg 3360 tgccccgtac cgtgaacgag atgaagcagg acttcgtggt caccgacttc tacaaggttg 3420 gaaacatcac cctgtacacc gagctgcacc ctttcttcga cttcacccac tgccaagaga 3480 actccgagac tgtggctctg tgcacccccc gtatcgtgat cggcaacctg cccgacggcc 3540 tggctcccgg tcccttccac gagctgagga cctgggagat catggaacac atgcgcctgc 3600 gtcccccacc cgactacgag gaaaccctgc gtctgttcaa gaccaccgtg acctccccca 3660 actaccccga gctgtgctac ctggtggacg tgctggtgca cggcaacgct gacgctttcc 3720 tgctgatccg cgctttcatc gctcgttgca tcgtgaacat gttccacacc cgtcagctgc 3780 tggtgttcgc tcactcctac gctctggtca ccctgatcgc tgagcacctg gctgacggtg 3840 ctctgccccc ccagctcctg ttccactacc gtaacctggt ggctgtgctg cgcctggtca 3900 cccgtatctc cgctctgccc ggcctgaaca acggccagct ggctgaggaa cccctgtccg 3960 cttacgtgaa cgctctgcac gaccacaggc tgtggccccc cttcgtgacc cacctccctc 4020 gtaacatgga aggtgtccag gtggtggctg atcgtcagcc cctgaacccc gctaacatcg 4080 aggctcgtca ccacggtgtc tccgacgtgc cccgtctggg tgctatggac gctgacgagc 4140 ccctgttcgt ggacgactac cgtgctaccg acgacgagtg gaccctgcaa aaggtgttct 4200 acctgtgcct gatccccgct atgaccaaca accgtgcttg cggcctgggc ctgaacctca 4260 agactctgct ggtggacctg ttctaccgtc ccgccttcct gctcatgccc gctgctaccg 4320 ctgtgtccac ctccggcacc acctccaagg aatccacctc tggtgtcacc cccgaggact 4380 ccgtggctgc tcagcgtcag gctgtgggcg agatgctgac cgagctggtc gaggacgtgg 4440 ccaccgacgc tcacacccct ctgctgcagg cttgccgcga gctgttcctg gctgtgcagt 4500 tcgtgggcga gcacgtgaag gtgctggaag tgcgtgctcc cctggaccac gctcagaggc 4560 agggactgcc cgacttcatc tcccgtcagc atgtgctgta caacggttgc tgcgtcgtga 4620 ccgctcctaa gaccctgatc gagtactccc tgcccgtgcc cttccaccgt ttctactcca 4680 accccaccat ctgcgctgct ctgtccgacg acatcaagcg ttacgtgacc gagttccccc 4740 actaccatag acacgatggt ggtttccccc tgcccaccgc tttcgctcac gagtaccaca 4800 actggctgcg tagccccttc tcccgttact ccgctacctg ccccaacgtg ctgcactccg 4860 tgatgaccct ggctgctatg ctgtacaaga tctcccccgt gtccctggtg ctgcagacca 4920 aggctcacat ccaccccggt ttcgctctga ccgctgtgcg taccgacacc ttcgaggtgg 4980 acatgctgct gtactccggc aagtcctgca cctccgtcat catcaacaac cccatcgtga 5040 ccaaggaaga gagggacatc tccaccacct accacgtgac ccagaacatc aacaccgtgg 5100 acatgggcct gggttacacc tccaacactt gcgtggccta cgtgaaccgc gtccgcaccg 5160 acatgggtgt ccgtgtgcag gacctgttcc gtgtgttccc catgaacgtg taccgccacg 5220 atgaggtgga ccgttggatc aggcacgctg ctggcgtcga gcgtccccag ctgctggaca 5280 ccgagactat ctccatgctg accttcggtt ccatgtccga gcgcaacgct gctgctaccg 5340 tgcacggcca gaaggctgtc tgcgagctga tcctgacccc tgtgactatg gacgtgaact 5400 acttcaagat caccaacaac cctcgtggtc gtgcttcctg catgctgggc gtggacccct 5460 acgacaccga ggctgccacc aaggctatct acgaccaccg cgaggctgac gctcagacct 5520 tcgctgctac ccacaaccca tgggcttccc aggctggttg cctgtccgac gtcctgtaca 5580 acacccgtca ccgcgagcgt ctgggctaca actccaagtt ctactccccc tgcgctcagt 5640 acttcaacac cgaggaaatc atcgctgcca acaagaccct cttcaagacc atcgacgagt 5700 acctgctgcg cgctaaggac tgcatccgtg gcgacaccga cactcagtac gtgtgcgtcg 5760 agggaaccga gcagctgatc gagaaccctt gccgtctgac ccaagaggct ctgcccatcc 5820 tgtccaccac caccctggct ctgatggaaa ctaagctgaa gggtggcgct ggtgctttcg 5880 ctacctccga gactcacttc ggcaactacg tcgtgggaga gatcatcccc ctgcagcagt 5940 ccatgctgtt caacagctaa gagctcaagc ttgtcgagaa gtactagagg atcataatca 6000 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 6060 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 6120 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 6180 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 6240 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc 6300 caccgctgag caataactat cataaccccc ggaatattaa tagatcatgg agataattaa 6360 aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag ttttgtaata 6420 aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg cggatccgcc 6480 accatggctg ctatggaagc taacatcttc tgcaccttcg accacaagct gtctatcgct 6540 gacgtgggca agctgaccaa gctggtggct gctgtggtgc ccatccccca gcgtctgcac 6600 ctgatcaagc actaccagct gggcctgcac cagttcgtgg accacacccg tggttacgtg 6660 cgtctgcgtg gcctgctgcg taacatgacc ctgaccctga tgcgtcgtgt cgagggcaac 6720 cagatcctgc tgcacgtgcc cacccacggc ctgctgtaca ccgtgctgaa caccggtccc 6780 gtgacctggg agaagggcga cgctctgtgc gtgctgcccc ccctgttcca cggtcccctg 6840 gctcgtgaaa acctgttgac cctgggccag tgggagctgg tgctgccctg gatcgtgccc 6900 atgcccctgg ctctggaaat caaccagcgc ctgctgatca tgggcctgtt ctccctggac 6960 cgttcctacg aagaagtgaa ggctgctgtc cagcagctgc agaccatcac cttccgtgac 7020 gctaccttca ccatccccga ccccgtgatc gaccagcacc tcctgatcga catgaagacc 7080 gcttgcctgt ccatgtccat ggtggctaac ctggcttccg agctgaccat gacctacgtc 7140 cgcaagctgg ctttggagga ctcttccatg ctgctggtca agtgccaaga gctgctgatg 7200 cgtctggacc gcgagcgttc cgtgggcgag cctcgtactc ccgctcgtcc tcagcacgtg 7260 tcccccgacg acgagatcgc tcgtctgtcc gctctgttcg tgatgctgcg tcagctggac 7320 gacctgatcc gcgagcaggt cgtgttcacc gtgtgcgacg tgagcccaga caacaagtcc 7380 gctacctgca tcttcaaggg ctaaggcgcg ccaagcttgt cgagaagtac tagaggatca 7440 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 7500 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 7560 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 7620 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 7680 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 7740 gctgccaccg ctgagcaata actatcataa cccccggaat attaatagat catggagata 7800 attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt aacagttttg 7860 taataaaaaa acctataaat attccggatt attcataccg tcccaccatc gggcgcggat 7920 cccggtccga agcgcgcgga attcaaaggc ctgccaccat ggaaatgaac aaggtgctgc 7980 atcaggatct ggtgcaggct acccgtcgta tcctgaagct gggcccctcc gagctgcgtg 8040 tgaccgacgc tggcctgatc tgcaagaacc ccaactactc cgtgtgcgac gctatgctca 8100 agaccgacac cgtgtactgc gtcgagtacc tgctgtccta ctgggagtcc cgtaccgacc 8160 acgtgccctg cttcatcttc aagaacaccg gttgcgctgt gtccctgtgc tgcttcgtgc 8220 gtgctcccgt gaagctggtg tcccctgctc gtcacgtggg cgagttcaac gtgctgaagg 8280 tcaacgagtc cctgatcgtg accctgaagg acatcgagga aatcaagccc tccgcttacg 8340 gtgtcctgac taagtgcgtc gtccgcaagt ccaactccgc ttccgtgttc aacatcgagc 8400 tgatcgcttt cggtcccgag aacgagggcg agtacgagaa cctgctgcgc gagctgtacg 8460 ctaagaaggc tgcttccacc tccctggctg tgcgtaacca cgtgaccgtg tcctcccact 8520 ccggttccgg tccctccctg tggcgtgctc gtatgtccgc tgctctgacc cgtaccgctg 8580 gcaagcgctc ctccaggact gctagccctc caccaccacc tcctcgtcac cctagctgct 8640 ctcccactat ggtggctgct ggtggagctg ctgctggtcc tagacctccc cctcctccta 8700 tggctgctgg atcctggcgt ctgtgccgtt gcgaggcttg catgggccgt tgcggttgcg 8760 cttccgaggg cgacgctgac gaggaagagg aagagttgct ggctctggct ggcgagggca 8820 aggctgctgc tgccgctgcc ggtcaagacg tcggtggttc cgctcgtcgt cccctcgagg 8880 aacacgtgtc ccgtcgtcgt ggtgtctcca cccaccaccg tcacccccct tccccacctt 8940 gcgctccctc cctggaacgt accggttacc gttgggctcc ttcctcctgg tggcgcgctc 9000 gttctggtcc ttcccgtccc cagtccggtc cctggctgcc tgctcgtttc gctaccctgg 9060 gtcccctggt cctggctctg ctgttggtgc tggccctgct gtggcgtggt cacggtcaat 9120 cccccagccc cacccgttcc gctcaccgtg actaaaagct tgtcgagaag tactagagga 9180 tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc 9240 tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag 9300 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 9360 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct 9420 gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga agctgagttg 9480 gctgctgtgg ctagctttgt ttaactttaa gaaggagata catctagaaa tattaataga 9540 tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt actgttttcg 9600 taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc gtcccaccat 9660 cgggcgcgga tcccggtccg aagcgcgcgg aattcaaagg cctacgtcga cgccaccatg 9720 tccaacaccg ctcccggtcc caccgtggct aacaagcgtg acgagaagca ccgtcacgtg 9780 gtcaacgtgg tgctcgagct gcccaccgag atctccgagg ctacccaccc cgtgctggct 9840 accatgctgt ccaagtacac ccgtatgtcc tccctgttca acgacaagtg cgctttcaag 9900 ctggacctgc tgcgtatggt ggctgtgtcc cgtacccgtc gctaaaagct tgtcgagaag 9960 tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac 10020 ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg 10080 tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa 10140 gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat 10200 gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga 10260 agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt gcccggaata 10320 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 10380 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 10440 cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcgccacca tggacgctcg 10500 tgctgtggct aagcgtcccc gtgaccccgc tgacgaggac aacgagctgg tcaccgctct 10560 gaaggctaag cgtgaagtga acaccatctc cgtgcgttac ctgtaccacg ctgaccacca 10620 ggctctgacc gctcgtttct tcgtgcccga gggcctggtc gagttcgagg ctcagcccgg 10680 tgctctgctg atccgtatgg aaaccggttg cgactccccc cgtcacctgt acatctccct 10740 gtacctgctg ggtatccgtg cttccaacgt gtccgcttcc acccgttgcc tgctcgagtc 10800 cgtgtacacc gcttccgctg ctcgtgctgc tctgcagtgg ctggacctgg gtccccacct 10860 cctgcaccgt cgtctggaaa ccctgggttg cgtcaagacc gtgtccctgg gtatcacctc 10920 cctgctgacc tgcgtgatgc gcggctacct gtacaacacc ctcaagaccg aggtgttcgc 10980 tctgatgatc cccaaggaca tgtacctgac ctgggaggaa acccgcggtc gtctgcagta 11040 cgtgtacctg atcatcgtgt acgactacga cggtcccgag actcgtcccg gtatctacgt 11100 gctgacctcc tctatcgctc actggcagac cctggtggac gtggcccgtg gaaagttcgc 11160 tcgtgaacgc tgctccttcg tgaaccgtcg tatcacccgt ccccgtcaga tccccctgtg 11220 caccggtgtc atccaaaagc tgggctggtg cctggctgac gacatccaca cctcattcct 11280 cgtgcacaag gaactgaagc tgtccgtcgt gcgtctggac aacttctccg tcgagctggg 11340 cgacttccgc gagttcgtgt aaaagcttgt cgagaagtac tagaggatca taatcagcca 11400 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 11460 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 11520 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 11580 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 11640 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgccaccg 11700 ctgagcaata actatcataa cccctagggg cctctaaacg ggtcttgagg ggttttttgc 11760 tgaaaggagg aactatatcc ggatctgaac aggagggaca gctgatagaa acagaagcca 11820 ctggagcacc tcaaaaacac catcatacac taaatcagta agttggcagc atcacccgac 11880 gcactttgcg ccgaataaat acctgtgacg gaagatcact tcgcagaata aataaatcct 11940 ggtgtccctg ttgataccgg gaagccctgg gccaactttt ggcgaaaatg agacgttgat 12000 cggcacgtaa gaggttccaa ctttcaccat aatgaaataa gatcactacc gggcgtattt 12060 tttgagttat cgagattttc aggagctaag gaagctaaaa tggagaaaaa aatcactgga 12120 tataccaccg ttgatatatc ccaatggcat cgtaaagaac attttgaggc atttcagtca 12180 gttgctcaat gtacctataa ccagaccgtt cagctggata ttacggcctt tttaaagacc 12240 gtaaagaaaa ataagcacaa gttttatccg gcctttattc acattcttgc ccgcctgatg 12300 aatgctcatc cggaattccg tatggcaatg aaagacggtg agctggtgat atgggatagt 12360 gttcaccctt gttacaccgt tttccatgag caaactgaaa cgttttcatc gctctggagt 12420 gaataccacg acgatttccg gcagtttcta cacatatatt cgcaagatgt ggcgtgttac 12480 ggtgaaaacc tggcctattt ccctaaaggg tttattgaga atatgttttt cgtctcagcc 12540 aatccctggg tgagtttcac cagttttgat ttaaacgtgg ccaatatgga caacttcttc 12600 gcccccgttt tcaccatggg caaatattat acgcaaggcg acaaggtgct gatgccgctg 12660 gcgattcagg ttcatcatgc cgtttgtgat ggcttccatg tcggcagaat gcttaatgaa 12720 ttacaacagt actgcgatga gtggcagggc ggggcgtaat ttttttaagg cagttattgg 12780 tgcccttaaa cgcctggttg ctacgcctga ataagtgata ataagcggat gaatggcaga 12840 aattcgaaag caaattcgac ccggtcgtcg gttcagggca gggtcgttaa atagccgctt 12900 atgtctattg ctggtttacc ggtttattga ctaccggaag cagtgtgacc gtgtgcttct 12960 caaatgcctg aggccagttt gctcaggctc tccccgtgga ggtaataatt gacgatatga 13020 tcatttattc tgcctcccag ctgacattca tccggggtca gcaccgtttc tgcggactgg 13080 ctttctacgt gttccgcttc ctttagcagc ccttgcgccc tgagtgcttg cggcagcgtg 13140 aagctaattc tgtcagccgt taagtgttcc tgtgtcactc aaaattgctt tgagaggctc 13200 taagggcttc tcagtgcgtt acatccctgg cttgttgtcc acaaccgtta aaccttaaaa 13260 gctttaaaag ccttatatat tctttttttt cttataaaac ttaaaacctt agaggctatt 13320 taagttgctg atttatatta attttattgt tcaaacatga gagcttagta cgtgaaacat 13380 gagagcttag tacgttagcc atgagagctt agtacgttag ccatgagggt ttagttcgtt 13440 aaacatgaga gcttagtacg ttaaacatga gagcttagta cgtgaaacat gagagcttag 13500 tacgtactat caacaggttg aactgctgat caacagatcc tctacgcggc cgcggtacca 13560 taacttcgta tagcatacat tatacgaagt tatctggttt aaacgtaccc gtagtggcta 13620 tggcagggct tgccgccccg acgttggctg cgagccctgg gccttcaccc gaacttgggg 13680 gttggggtgg ggaaaaggaa gaaacgcggg cgtattggtc ccaatggggt ctcggtgggg 13740 tatcgacaga gtgccagccc tgggaccgaa ccccgcgttt atgaacaaac gacccaacac 13800 ccgtgcgttt tattctgtct ttttattgcc gtcatagcgc gggttccttc cggtattgtc 13860 tccttccgtg tttcagttag cctcccccat ctcccggtac cgcatgctat gcatcagctg 13920 ctagcttagc gagcgtccac agcctgggga ccgtaacggg agtgagcggg caggttcaca 13980 cgggtctgct tcagctcagg gggcaggcca gcgtagtact tgtccaggtg acgcagcagg 14040 ggggggtcca gctggtgacg caggcagaat tccttcacag cgttgtacag gccgtagaac 14100 agggtgatac cctcgggagc agcagcggtg gacacgggca gacgcacagc acggttggta 14160 cgggtagcct cgttacggat agccaccacc acgttgaaca gggagggggg caccagctcg 14220 aaacccagca cgtgttcggt gaagatggaa cgaccgtagg acagacgagt caggtcgtaa 14280 ccacggcaca ggtcgtccac gcaagtgtac acagcggggg aaccgtcgcc gcactcggag 14340 taaccgcgca tcacggtcat ccaacgggga gcggtgtcgg aggacagcag ggtcagcaga 14400 gcacgcagct ggtcggggtt gttgtacagc agggccaggg tgtccaggaa agcgtcgtcc 14460 agcagcacgg agttagcagc ctcgggggtc acgggacggt aacggatcag ctgggacagg 14520 ggaccgtccc tacgggtcac gttgaccagg ggacgcagcc aggactcgta cttgtcgccc 14580 tggaacacct ctcccagcag gcaacgacgg gtcagctcgg ggcactcagc gggcaccttc 14640 tcagccacgg tgggagccac ggacacggta gcggaggaca cgatgggcag cagcaggcag 14700 caccacagca gagccacggg accgggggag aaggagaaac cgcagtcggg acgacggcac 14760 atggtggctc gagatcccgg gtgatcaagt cttcgtcgag tgattgtaaa taaaatgtaa 14820 tttacagtat agtattttaa ttaatataca aatgatttga taataattct tatttaacta 14880 taatatattg tgttgggttg aattaaaggt ccgtatacta gtatcgattc gcgacctact 14940 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 15000 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 15060 cataccgtcc caccatcggg cgcggatccg ccaccatgaa ctccaaggac ctgaccccct 15120 tcctgaccac cctgtggctg ctgctggacc actcccgtgt gcctcgtgtg cgtgctgagg 15180 aatgctgcga agtgatcaac gtgaaccacc cccccgagcg ctgctacgac ttcaagatgt 15240 gcaacctgtt caccgtggct ctgcgttgcc ccgacggcga agtgtgctac tcccccgaaa 15300 agaccgctga gatccgtggt atcgtgacca ccatgaccca ctccctgacc cgtcaagtga 15360 tccacaacaa gctgaccagc tgcaactaca accccctgta cctcgaggct gacggtcgta 15420 tccgttgcgg caaggtgtcc gacaaggctc agtacctgct gggtgctgct ggttccgtgc 15480 cctaccgttg gatcaacctc gagtacgaca agatcacccg tatcgtgggc ctggaccagt 15540 acctcgagtc cgtgaagaag cacaagcgtc tggacgtgtg ccgtgctaag atgggttaca 15600 tgctgcagta aaagcttgtc gagaagtact agaggatcat aatcagccat accacatttg 15660 tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa 15720 tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca 15780 atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt 15840 ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat 15900 ccggctgcta acaaagcccg aaaggaagct gagttggctg ctgtggctag ctttgtttaa 15960 ctttaagaag gagatacatc tagaccggaa tattaataga tcatggagat aattaaaatg 16020 ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa 16080 aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccacca 16140 tgctgcgtct gctgctgcgt caccacttcc actgcctgct gctgtgcgct gtgtgggcta 16200 ccccctgcct ggcttcccct tggtccaccc tgaccgctaa ccagaacccc tccccaccct 16260 ggtccaagct gacctactcc aagccccacg acgctgctac cttctactgc cccttcctgt 16320 acccatcccc ccctcgttcc ccactgcagt tctccggttt ccagcgtgtg ctgaccggtc 16380 ccgagtgccg taacgagact ctgtacctgc tgtacaaccg cgagggccag accctggtcg 16440 agaggtcctc cacctgggtc aagaaggtca tctggtactt gtccggtcgt aaccagacca 16500 tcctgcagcg tatgccccgt accgcttcca agccctccga cggcaacgtg cagatctccg 16560 tcgaggacgc taagatcttc ggtgctcaca tggtgcccaa gcagaccaag ctgctgcgtt 16620 tcgtggtcaa cgacggcacc cgttaccaga tgtgcgtgat gaagctcgag tcctgggctc 16680 acgtgttccg tgactactcc gtgtccttcc aagtgcgcct gaccttcacc gaggctaaca 16740 accagaccta caccttctgc acccacccca acctgatcgt gtaaaagctt gtcgagaagt 16800 actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc 16860 tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt 16920 ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag 16980 catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg 17040 tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa 17100 gctgagttgg ctgctgggtg cctaatgagt gagctaactc acattaattg cccggaatat 17160 taatagatca tggagataat taaaatgata accatctcgc aaataaataa gtattttact 17220 gttttcgtaa cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc 17280 ccaccatcgg gcgcggatcc gccaccatgc gtctgtgccg tgtgtggctg tccgtgtgcc 17340 tgtgcgctgt ggtgctgggc cagtgccagc gtgaaaccgc tgagaagaac gactactacc 17400 gtgtgcccca ctactgggac gcttgctccc gtgctctgcc cgaccagacc cgttacaagt 17460 acgtcgagca gctggtggac ctgaccctga actaccacta cgacgcttcc cacggcctgg 17520 acaacttcga cgtgctgaag cgtatcaacg tgaccgaggt gtccctgctg atctccgact 17580 tccgtcgtca gaaccgtcgt ggtggcacca acaagcgtac caccttcaac gctgctggtt 17640 ccctggctcc ccacgctcgt tccctcgagt tctccgtgcg tctgttcgct aactaaaagc 17700 ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag gttttacttg 17760 ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg 17820 ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt 17880 tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg 17940 tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc tgctaacaaa 18000 gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactatc ataacccccg 18060 gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat 18120 tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat 18180 accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcaa aggcctaccg 18240 tcgacgccac catggaatcc cgtatctggt gcctggtcgt gtgcgtgaac ctgtgcatcg 18300 tgtgcctggg tgctgctgtg tcctcctcct ccacccgtgg cacctccgct acccactccc 18360 accactcctc ccacaccacc tccgccgctc actcccgttc cggttccgtg tcccagcgtg 18420 tgacctcctc ccagaccgtg tcccacggtg tcaacgagac tatctacaac accaccctga 18480 agtacggcga cgtcgtgggt gtcaacacca ccaagtaccc ctaccgtgtg tgctccatgg 18540 ctcagggcac cgacctgatc cgtttcgagc gtaacatcgt gtgcacctcc atgaagccca 18600 tcaacgagga cctggacgag ggtatcatgg tggtgtacaa gcgcaacatc gtggctcaca 18660 ccttcaaggt ccgcgtgtac cagaaggtgc tgaccttccg tcgttcctac gcttacatcc 18720 acaccactta cctgctgggt tccaacaccg agtacgtggc ccctcccatg tgggagatcc 18780 accacatcaa ctcccactcc cagtgctact cctcttactc ccgtgtgatc gctggcaccg 18840 tgttcgtggc ttaccaccgt gactcctacg agaacaagac catgcagctg atgcccgacg 18900 actactccaa cacccactcc acccgttacg tgaccgtgaa ggaccagtgg cactcccgtg 18960 gttccacctg gctgtaccgt gaaacctgca acctgaactg catggtcacc atcaccaccg 19020 ctcgttccaa gtacccttac cacttcttcg ctacctccac cggcgacgtg gtggacatct 19080 cccccttcta caacggtact aaccgtaacg cttcctactt cggcgagaac gctgacaagt 19140 tcttcatctt ccccaactac accatcgtgt ccgacttcgg tcgtcccaac tccgctctgg 19200 aaacccaccg tctggtggct ttcttggagc gtgctgactc cgtgatctcc tgggacatcc 19260 aggacgagaa gaacgtgacc tgccagctga ccttctggga ggcttccgag cgtaccatcc 19320 gttccgaggc tgaggactcc taccacttct ccagcgctaa gatgaccgct accttcctgt 19380 ccaagaaaca agaggtcaac atgtccgact ccgccctgga ctgcgtgcgt gacgaggcta 19440 tcaacaagct gcagcagatc ttcaacacct cctacaacca gacctacgag aagtacggaa 19500 acgtgtccgt gttcgagact accggtggcc tggtggtgtt ctggcagggt atcaagcaga 19560 agtccctggt cgagctggaa cgtctggcta accgttcctc cctgaacctg acccacaacc 19620 gtaccaagcg ttccaccgac ggcaacaacg ctactcacct gtccaacatg gaatccgtgc 19680 acaacctggt gtacgctcag ctgcagttca cctacgacac cctgcgcggt tacatcaacc 19740 gtgctctggc tcagatcgct gaggcttggt gcgtggacca gcgtcgtacc ctggaagtgt 19800 tcaaggaact gtccaagatc aacccctccg ctatcctgtc cgccatctac aacaagccta 19860 tcgctgctcg tttcatgggc gacgtgctgg gcctggcttc ctgcgtgacc atcaaccaga 19920 cttccgtgaa ggtgctgcgt gacatgaacg tgaaggaatc ccccggtcgt tgctactccc 19980 gtcccgtggt catcttcaac ttcgctaact cctcctacgt gcagtacggc cagctgggcg 20040 aggacaacga gatcctgctg ggcaaccacc gtaccgagga atgccagctg ccctccctga 20100 agatcttcat cgctggcaac tccgcttacg aatacgtgga ctacctgttc aagcgcatga 20160 tcgacctgtc ctccatctct accgtggact ccatgatcgc tctggacatc gaccccctgg 20220 aaaacaccga cttccgtgtg ctggaactgt actcccagaa ggaactgcgt tccatcaacg 20280 tgttcgacct ggaagagatc atgcgcgagt tcaactccta caagcagcgt gttaagtacg 20340 tcgaggacaa ggtggtggac cccctgcccc cctacctgaa gggactggac gacctgatgt 20400 ccggcctggg agctgccggc aaggctgtgg gtgtcgctat cggtgctgtg ggtggtgctg 20460 tggcttccgt ggtcgagggt gtcgccacct tcctgaagaa ccccttcggt gctttcacca 20520 tcatcctggt ggctatcgct gtggtcatca tcatctacct gatctacacc cgtcagcgtc 20580 gtctgtgcat gcagcccctg cagaacctgt tcccctacct ggtgtccgct gacggtacta 20640 ccgtgacctc cggcaacacc aaggacacct ccctgcaggc tcccccatcc tacgaggaat 20700 ccgtctacaa ctccggtcgc aagggtcccg gtcccccttc ctccgacgct tctaccgctg 20760 ctcccccata caccaacgag caggcttacc agatgctgct ggctctcgtg cgtctggacg 20820 ctgagcagcg tgcacagcag aacggcaccg actccctgga cggccagacc ggaacccagg 20880 acaagggcca gaagcccaac ctgctggacc gtctgcgtca ccgcaagaac ggttaccgtc 20940 acctgaagga ctccgacgag gaagagaacg tctaaggcgc gccaagcttg tcgagaagta 21000 ctagagatca taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc 21060 ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 21120 attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 21180 tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 21240 tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc 21300 tgggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 21360 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 21420 cataccgtcc caccatcggg cgcggatccg ccaccatgcg tcccggcctg ccctcctacc 21480 tgatcgtgct ggctgtgtgc ctgctgtccc acctcctgtc ctcccgttac ggtgctgagg 21540 ctatctccga gcccctggac aaggctttcc acctcctgct gaacacctac ggtcgtccta 21600 tccgtttcct gcgcgagaac accacccagt gcacctacaa ctcctccctg cgcaactcca 21660 ccgtcgtccg cgagaacgct atctccttca acttcttcca gtcctacaac cagtactacg 21720 tgttccacat gccccgttgc ctgttcgctg gtcccctggc tgagcagttc ctgaaccagg 21780 tggacctgac cgagactctc gagcgttacc agcagcgtct gaacacttac gctctggtgt 21840 ccaaggacct ggcttcctac cgttccttca gccagcagct gaaggctcag gactccctgg 21900 gcgagcagcc caccactgtg cctcccccta tcgacctgtc catcccccac gtgtggatgc 21960 ccccccagac cactcctcac ggctggaccg agtcccacac cacctccgga ctgcaccgtc 22020 cccacttcaa ccagacctgc atcctgttcg acggtcacga cctgctgttc tccaccgtga 22080 ccccctgcct gcaccagggc ttctacctca tcgacgagct gcgttacgtg aagatcaccc 22140 tgaccgagga tttcttcgtg gtcaccgtgt ccatcgacga cgacaccccc atgctgctga 22200 tcttcggtca cctcccccgt gtgctgttca aggctcccta ccagcgtgac aacttcatcc 22260 tgcgtcagac cgagaagcac gagctgctgg tgctggtcaa gaaggaccag ctgaaccgtc 22320 actcttacct gaaggacccc gacttcctgg acgctgctct ggacttcaac tacctggacc 22380 tgtccgctct gctgaggaac tccttccacc gttacgctgt ggacgtgctg aagtccggtc 22440 gttgccagat gctggaccgt cgtaccgtcg agatggcttt cgcttacgcc ctggctctgt 22500 tcgctgctgc tcgtcaagaa gaggctggcg ctcaggtgtc cgtgccccgt gctctggacc 22560 gtcaggctgc tctgctgcag atccaagagt tcatgatcac ttgcctgtcc cagacccccc 22620 ctcgtaccac cctgctgctg taccccaccg ctgtggacct ggctaagcgt gctctgtgga 22680 cccccaacca gatcaccgac atcacctccc tcgtgcgtct ggtgtacatc ctgtccaagc 22740 agaaccagca gcacctgatc ccccagtggg ctctgcgtca gatcgctgac ttcgctctga 22800 agctgcacaa gacccacctg gcttcattcc tcagcgcttt cgctcgccaa gagctgtacc 22860 tgatgggttc cctggtgcac tccatgctgg tgcacaccac cgagcgtcgc gagatcttca 22920 tcgtggaaac cggcctgtgc tccctggccg agctgtccca cttcacccag ctgctggctc 22980 acccccacca cgagtacctg tccgacctgt acaccccctg ctcctcttcc ggtcgtcgtg 23040 accactccct ggaacgtctg acccgtctgt tccccgacgc taccgtgcct accaccgtgc 23100 ctgctgctct gtccatcctg tctaccatgc agccctccac cctggaaacc ttccccgacc 23160 tgttctgcct gcctctgggc gagtccttct ccgctctgac cgtgtccgag cacgtgtcct 23220 acgtggtcac caaccagtac ctgatcaagg gcatctccta ccccgtgtcc accaccgtcg 23280 tgggccagtc cctgatcatc acccagaccg actcccagac caagtgcgag ctgacccgta 23340 acatgcacac cactcactcc atcaccgctg ctctgaacat ctccctcgag aactgcgctt 23400 tctgccagtc cgctctgttg gagtacgacg acactcaggg tgtcatcaac atcatgtaca 23460 tgcacgactc cgacgacgtg ctgttcgctc tggaccccta caacgaggtg gtggtgtcct 23520 ccccccgtac ccactacctg atgctgctga agaacggcac cgtgctggaa gtgaccgacg 23580 tggtggtgga cgctaccgac cgtctgctga tgatgtccgt gtacgctctg tccgctatca 23640 tcggcatcta cctgctgtac cgtatgctga agacctgcta aggcgccaag ctttgtcgag 23700 aagtactaga ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa 23760 aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac 23820 ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 23880 aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat 23940 catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca aagcccgaaa 24000 ggaagctgag ttggctgctg ctgagtagtg cgcgagcaaa atttaagcta caacaaggca 24060 cgcgtccgga atattaatag atcatggaga taattaaaat gataaccatc tcgcaaataa 24120 ataagtattt tactgttttc gtaacagttt tgtaataaaa aaacctataa atattccgga 24180 ttattcatac cgtcccacca tcgggcgcgg atcccggtcc gaagcgcgcg gaattcaaag 24240 gcctacgtcg acgccaccat ggaatcccgt ggtcgtcgtt gccccgagat gatctccgtg 24300 ctgggtccca tctccggtca cgtcctgaag gctgtgttct cccgtggcga cacccccgtg 24360 ctgccccacg aaactcgtct gctgcagacc ggtatccacg tgcgtgtgtc ccagccctcc 24420 ctgatcctgg tgtcccagta cacccccgac tccacccctt gccaccgcgg agacaaccag 24480 ctgcaggtcc agcacaccta cttcaccggt tccgaggtcg agaacgtgtc cgtgaacgtg 24540 cacaacccca ccggtcgttc catctgcccc tcccaagagc ccatgtccat ctacgtgtac 24600 gctctgcccc tgaagatgct gaacatcccc tccatcaacg tgcaccacta cccctccgct 24660 gctgagcgca agcaccgtca cctccccgtg gctgacgctg tgatccacgc ttccggcaag 24720 cagatgtggc aggctcgtct gaccgtgtcc ggcctggctt ggacccgtca gcagaaccag 24780 tggaaggaac ccgacgtgta ctacacctcc gctttcgtgt tccccaccaa ggacgtggcc 24840 ctgcgtcacg tcgtgtgcgc tcacgaactc gtgtgctcca tggaaaacac ccgtgctacc 24900 aagatgcaag tgatcggcga ccagtacgtg aaggtgtacc tggaatcctt ctgcgaggac 24960 gtgccctccg gcaagctgtt catgcacgtg accctgggtt ccgacgtgga agaggacctg 25020 accatgaccc gtaaccccca gcccttcatg cgtccccacg agcgtaacgg tttcaccgtg 25080 ctgtgcccca agaacatgat catcaagccc ggcaagatct cccacatcat gctggacgtg 25140 gccttcacct cccacgagca cttcggcctg ctgtgcccta agtccatccc cggcctgtcc 25200 atctccggca acctgctgat gaacggccag cagatcttcc tggaagtgca ggctatccgt 25260 gaaaccgtcg agctgcgtca gtacgaccct gtggctgctc tgttcttctt cgacatcgac 25320 ctgctgctgc agcgtggtcc ccagtactcc gagcacccca ccttcaccag ccagtaccgt 25380 atccagggca agctggaata ccgtcacacc tgggaccgtc acgacgaggg tgctgctcag 25440 ggcgacgacg acgtgtggac ctccggttcc gactccgacg aggaactggt caccaccgag 25500 cgcaagaccc cccgtgtgac cggtggtggt gctatggctg gtgcttccac ctccgctggt 25560 cgcaagcgca agtccgcttc ctccgctacc gcttgcaccg ctggtgtcat gacccgtggt 25620 cgcctgaagg ctgagtccac cgtggctccc gaagaggaca ctgacgagga ctccgacaac 25680 gagatccaca accccgctgt gttcacctgg cccccctggc aggctggtat cctggctcgt 25740 aacctggtgc ccatggtggc taccgtgcag ggccagaacc tgaagtacca agagttcttc 25800 tgggacgcca acgacatcta ccgtatcttc gctgagctgg aaggcgtgtg gcagcccgct 25860 gctcagccca agcgtcgtcg tcaccgtcag gacgctctgc ctggtccctg tatcgcttcc 25920 acccccaaga agcaccgcgg ctaaaagctt gtcgagaagt actagaggat cataatcagc 25980 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 26040 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 26100 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 26160 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 26220 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac 26280 cgctgagcaa taactatcat aacccctagg agatccgaac cagataagtg aaatctagtt 26340 ccaaactatt ttgtcatttt taattttcgt attagcttac gacgctacac ccagttccca 26400 tctattttgt cactcttccc taaataatcc ttaaaaactc catttccacc cctcccagtt 26460 cccaactatt ttgtccgccc aca 26483 <210> 58 <211> 27348 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 58 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgcccaccgc tgagcaataa ctatcataac ccccggaata ttaatagatc atggagataa 7200 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 7260 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 7320 cgccaccatg gctgctatgg aagctaacat cttctgcacc ttcgaccaca agctgtctat 7380 cgctgacgtg ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc cccagcgtct 7440 gcacctgatc aagcactacc agctgggcct gcaccagttc gtggaccaca cccgtggtta 7500 cgtgcgtctg cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc gtgtcgaggg 7560 caaccagatc ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc tgaacaccgg 7620 tcccgtgacc tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt tccacggtcc 7680 cctggctcgt gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc cctggatcgt 7740 gcccatgccc ctggctctgg aaatcaacca gcgcctgctg atcatgggcc tgttctccct 7800 ggaccgttcc tacgaagaag tgaaggctgc tgtccagcag ctgcagacca tcaccttccg 7860 tgacgctacc ttcaccatcc ccgaccccgt gatcgaccag cacctcctga tcgacatgaa 7920 gaccgcttgc ctgtccatgt ccatggtggc taacctggct tccgagctga ccatgaccta 7980 cgtccgcaag ctggctttgg aggactcttc catgctgctg gtcaagtgcc aagagctgct 8040 gatgcgtctg gaccgcgagc gttccgtggg cgagcctcgt actcccgctc gtcctcagca 8100 cgtgtccccc gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc tgcgtcagct 8160 ggacgacctg atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc cagacaacaa 8220 gtccgctacc tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa gtactagagg 8280 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 8340 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 8400 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 8460 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 8520 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 8580 ggctgctgcc accgctgagc aataactatc ataacccccg gaatattaat agatcatgga 8640 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 8700 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 8760 ggatcccggt ccgaagcgcg cggaattcaa aggcctgcca ccatggaaat gaacaaggtg 8820 ctgcatcagg atctggtgca ggctacccgt cgtatcctga agctgggccc ctccgagctg 8880 cgtgtgaccg acgctggcct gatctgcaag aaccccaact actccgtgtg cgacgctatg 8940 ctcaagaccg acaccgtgta ctgcgtcgag tacctgctgt cctactggga gtcccgtacc 9000 gaccacgtgc cctgcttcat cttcaagaac accggttgcg ctgtgtccct gtgctgcttc 9060 gtgcgtgctc ccgtgaagct ggtgtcccct gctcgtcacg tgggcgagtt caacgtgctg 9120 aaggtcaacg agtccctgat cgtgaccctg aaggacatcg aggaaatcaa gccctccgct 9180 tacggtgtcc tgactaagtg cgtcgtccgc aagtccaact ccgcttccgt gttcaacatc 9240 gagctgatcg ctttcggtcc cgagaacgag ggcgagtacg agaacctgct gcgcgagctg 9300 tacgctaaga aggctgcttc cacctccctg gctgtgcgta accacgtgac cgtgtcctcc 9360 cactccggtt ccggtccctc cctgtggcgt gctcgtatgt ccgctgctct gacccgtacc 9420 gctggcaagc gctcctccag gactgctagc cctccaccac cacctcctcg tcaccctagc 9480 tgctctccca ctatggtggc tgctggtgga gctgctgctg gtcctagacc tccccctcct 9540 cctatggctg ctggatcctg gcgtctgtgc cgttgcgagg cttgcatggg ccgttgcggt 9600 tgcgcttccg agggcgacgc tgacgaggaa gaggaagagt tgctggctct ggctggcgag 9660 ggcaaggctg ctgctgccgc tgccggtcaa gacgtcggtg gttccgctcg tcgtcccctc 9720 gaggaacacg tgtcccgtcg tcgtggtgtc tccacccacc accgtcaccc cccttcccca 9780 ccttgcgctc cctccctgga acgtaccggt taccgttggg ctccttcctc ctggtggcgc 9840 gctcgttctg gtccttcccg tccccagtcc ggtccctggc tgcctgctcg tttcgctacc 9900 ctgggtcccc tggtcctggc tctgctgttg gtgctggccc tgctgtggcg tggtcacggt 9960 caatccccca gccccacccg ttccgctcac cgtgactaaa agcttgtcga gaagtactag 10020 aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca 10080 cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt 10140 gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 10200 ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 10260 atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga 10320 gttggctgct gtggctagct ttgtttaact ttaagaagga gatacatcta gaaatattaa 10380 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 10440 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 10500 ccatcgggcg cggatcccgg tccgaagcgc gcggaattca aaggcctacg tcgacgccac 10560 catgtccaac accgctcccg gtcccaccgt ggctaacaag cgtgacgaga agcaccgtca 10620 cgtggtcaac gtggtgctcg agctgcccac cgagatctcc gaggctaccc accccgtgct 10680 ggctaccatg ctgtccaagt acacccgtat gtcctccctg ttcaacgaca agtgcgcttt 10740 caagctggac ctgctgcgta tggtggctgt gtcccgtacc cgtcgctaaa agcttgtcga 10800 gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa 10860 aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa 10920 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 10980 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 11040 tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa 11100 aggaagctga gttggctgct gggtgcctaa tgagtgagct aactcacatt aattgcccgg 11160 aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt 11220 ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata 11280 ccgtcccacc atcgggcgcg gatcccggtc cgaagcgcgc ggaattcgcc accatggacg 11340 ctcgtgctgt ggctaagcgt ccccgtgacc ccgctgacga ggacaacgag ctggtcaccg 11400 ctctgaaggc taagcgtgaa gtgaacacca tctccgtgcg ttacctgtac cacgctgacc 11460 accaggctct gaccgctcgt ttcttcgtgc ccgagggcct ggtcgagttc gaggctcagc 11520 ccggtgctct gctgatccgt atggaaaccg gttgcgactc cccccgtcac ctgtacatct 11580 ccctgtacct gctgggtatc cgtgcttcca acgtgtccgc ttccacccgt tgcctgctcg 11640 agtccgtgta caccgcttcc gctgctcgtg ctgctctgca gtggctggac ctgggtcccc 11700 acctcctgca ccgtcgtctg gaaaccctgg gttgcgtcaa gaccgtgtcc ctgggtatca 11760 cctccctgct gacctgcgtg atgcgcggct acctgtacaa caccctcaag accgaggtgt 11820 tcgctctgat gatccccaag gacatgtacc tgacctggga ggaaacccgc ggtcgtctgc 11880 agtacgtgta cctgatcatc gtgtacgact acgacggtcc cgagactcgt cccggtatct 11940 acgtgctgac ctcctctatc gctcactggc agaccctggt ggacgtggcc cgtggaaagt 12000 tcgctcgtga acgctgctcc ttcgtgaacc gtcgtatcac ccgtccccgt cagatccccc 12060 tgtgcaccgg tgtcatccaa aagctgggct ggtgcctggc tgacgacatc cacacctcat 12120 tcctcgtgca caaggaactg aagctgtccg tcgtgcgtct ggacaacttc tccgtcgagc 12180 tgggcgactt ccgcgagttc gtgtaaaagc ttgtcgagaa gtactagagg atcataatca 12240 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 12300 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 12360 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 12420 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 12480 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc 12540 accgctgagc aataactatc ataaccccta ggggcctcta aacgggtctt gaggggtttt 12600 ttgctgaaag gaggaactat atccggatct gaacaggagg gacagctgat agaaacagaa 12660 gccactggag cacctcaaaa acaccatcat acactaaatc agtaagttgg cagcatcacc 12720 cgacgcactt tgcgccgaat aaatacctgt gacggaagat cacttcgcag aataaataaa 12780 tcctggtgtc cctgttgata ccgggaagcc ctgggccaac ttttggcgaa aatgagacgt 12840 tgatcggcac gtaagaggtt ccaactttca ccataatgaa ataagatcac taccgggcgt 12900 attttttgag ttatcgagat tttcaggagc taaggaagct aaaatggaga aaaaaatcac 12960 tggatatacc accgttgata tatcccaatg gcatcgtaaa gaacattttg aggcatttca 13020 gtcagttgct caatgtacct ataaccagac cgttcagctg gatattacgg cctttttaaa 13080 gaccgtaaag aaaaataagc acaagtttta tccggccttt attcacattc ttgcccgcct 13140 gatgaatgct catccggaat tccgtatggc aatgaaagac ggtgagctgg tgatatggga 13200 tagtgttcac ccttgttaca ccgttttcca tgagcaaact gaaacgtttt catcgctctg 13260 gagtgaatac cacgacgatt tccggcagtt tctacacata tattcgcaag atgtggcgtg 13320 ttacggtgaa aacctggcct atttccctaa agggtttatt gagaatatgt ttttcgtctc 13380 agccaatccc tgggtgagtt tcaccagttt tgatttaaac gtggccaata tggacaactt 13440 cttcgccccc gttttcacca tgggcaaata ttatacgcaa ggcgacaagg tgctgatgcc 13500 gctggcgatt caggttcatc atgccgtttg tgatggcttc catgtcggca gaatgcttaa 13560 tgaattacaa cagtactgcg atgagtggca gggcggggcg taattttttt aaggcagtta 13620 ttggtgccct taaacgcctg gttgctacgc ctgaataagt gataataagc ggatgaatgg 13680 cagaaattcg aaagcaaatt cgacccggtc gtcggttcag ggcagggtcg ttaaatagcc 13740 gcttatgtct attgctggtt taccggttta ttgactaccg gaagcagtgt gaccgtgtgc 13800 ttctcaaatg cctgaggcca gtttgctcag gctctccccg tggaggtaat aattgacgat 13860 atgatcattt attctgcctc ccagctgaca ttcatccggg gtcagcaccg tttctgcgga 13920 ctggctttct acgtgttccg cttcctttag cagcccttgc gccctgagtg cttgcggcag 13980 cgtgaagcta attctgtcag ccgttaagtg ttcctgtgtc actcaaaatt gctttgagag 14040 gctctaaggg cttctcagtg cgttacatcc ctggcttgtt gtccacaacc gttaaacctt 14100 aaaagcttta aaagccttat atattctttt ttttcttata aaacttaaaa ccttagaggc 14160 tatttaagtt gctgatttat attaatttta ttgttcaaac atgagagctt agtacgtgaa 14220 acatgagagc ttagtacgtt agccatgaga gcttagtacg ttagccatga gggtttagtt 14280 cgttaaacat gagagcttag tacgttaaac atgagagctt agtacgtgaa acatgagagc 14340 ttagtacgta ctatcaacag gttgaactgc tgatcaacag atcctctacg cggccgcggt 14400 accataactt cgtatagcat acattatacg aagttatctg gtttaaacgt acccgtagtg 14460 gctatggcag ggcttgccgc cccgacgttg gctgcgagcc ctgggccttc acccgaactt 14520 gggggttggg gtggggaaaa ggaagaaacg cgggcgtatt ggtcccaatg gggtctcggt 14580 ggggtatcga cagagtgcca gccctgggac cgaaccccgc gtttatgaac aaacgaccca 14640 acacccgtgc gttttattct gtctttttat tgccgtcata gcgcgggttc cttccggtat 14700 tgtctccttc cgtgtttcag ttagcctccc ccatctcccg gtaccgcatg ctatgcatca 14760 gctgctagct tagcgagcgt ccacagcctg gggaccgtaa cgggagtgag cgggcaggtt 14820 cacacgggtc tgcttcagct cagggggcag gccagcgtag tacttgtcca ggtgacgcag 14880 cagggggggg tccagctggt gacgcaggca gaattccttc acagcgttgt acaggccgta 14940 gaacagggtg ataccctcgg gagcagcagc ggtggacacg ggcagacgca cagcacggtt 15000 ggtacgggta gcctcgttac ggatagccac caccacgttg aacagggagg ggggcaccag 15060 ctcgaaaccc agcacgtgtt cggtgaagat ggaacgaccg taggacagac gagtcaggtc 15120 gtaaccacgg cacaggtcgt ccacgcaagt gtacacagcg ggggaaccgt cgccgcactc 15180 ggagtaaccg cgcatcacgg tcatccaacg gggagcggtg tcggaggaca gcagggtcag 15240 cagagcacgc agctggtcgg ggttgttgta cagcagggcc agggtgtcca ggaaagcgtc 15300 gtccagcagc acggagttag cagcctcggg ggtcacggga cggtaacgga tcagctggga 15360 caggggaccg tccctacggg tcacgttgac caggggacgc agccaggact cgtacttgtc 15420 gccctggaac acctctccca gcaggcaacg acgggtcagc tcggggcact cagcgggcac 15480 cttctcagcc acggtgggag ccacggacac ggtagcggag gacacgatgg gcagcagcag 15540 gcagcaccac agcagagcca cgggaccggg ggagaaggag aaaccgcagt cgggacgacg 15600 gcacatggtg gctcgagatc ccgggtgatc aagtcttcgt cgagtgattg taaataaaat 15660 gtaatttaca gtatagtatt ttaattaata tacaaatgat ttgataataa ttcttattta 15720 actataatat attgtgttgg gttgaattaa aggtccgtat actagtatcg attcgcgacc 15780 tactccggaa tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa 15840 taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat 15900 tattcatacc gtcccaccat cgggcgcgga tccgccacca tgaactccaa ggacctgacc 15960 cccttcctga ccaccctgtg gctgctgctg gaccactccc gtgtgcctcg tgtgcgtgct 16020 gaggaatgct gcgaagtgat caacgtgaac cacccccccg agcgctgcta cgacttcaag 16080 atgtgcaacc tgttcaccgt ggctctgcgt tgccccgacg gcgaagtgtg ctactccccc 16140 gaaaagaccg ctgagatccg tggtatcgtg accaccatga cccactccct gacccgtcaa 16200 gtgatccaca acaagctgac cagctgcaac tacaaccccc tgtacctcga ggctgacggt 16260 cgtatccgtt gcggcaaggt gtccgacaag gctcagtacc tgctgggtgc tgctggttcc 16320 gtgccctacc gttggatcaa cctcgagtac gacaagatca cccgtatcgt gggcctggac 16380 cagtacctcg agtccgtgaa gaagcacaag cgtctggacg tgtgccgtgc taagatgggt 16440 tacatgctgc agtaaaagct tgtcgagaag tactagagga tcataatcag ccataccaca 16500 tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat 16560 aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa 16620 agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt 16680 ttgtccaaac tcatcaatgt atcttatcat gtctggatct gatcactgct tgagcctaga 16740 agatccggct gctaacaaag cccgaaagga agctgagttg gctgctgtgg ctagctttgt 16800 ttaactttaa gaaggagata catctagacc ggaatattaa tagatcatgg agataattaa 16860 aatgataacc atctcgcaaa taaataagta ttttactgtt ttcgtaacag ttttgtaata 16920 aaaaaaccta taaatattcc ggattattca taccgtccca ccatcgggcg cggatccgcc 16980 accatgctgc gtctgctgct gcgtcaccac ttccactgcc tgctgctgtg cgctgtgtgg 17040 gctaccccct gcctggcttc cccctggttc accctgaccg ctaaccagaa cccctcccca 17100 ccctggtcca agctgaccta ccccaagccc cacgacgctg ctaccttcta ctgccccttc 17160 ctgtacccat ccccacctcg ttccccatcc cagttctccg gtttccagcg tgtgtccacc 17220 ggtcccgagt gccgtaacga gactctgtac ctgctgtaca accgcgaggg ccagaccctg 17280 gtcgagaggt cctccacctg ggtcaagaag gtcatctggt acttgtccgg tcgtaaccag 17340 accatcctgc agcgtatgcc ccgtaccgct tccaagccct ccgacggcaa cgtgcagatc 17400 tccgtcgagg acgctaagat cttcggtgct cacatggtgc ccaagcagac caagctgctg 17460 cgtttcgtgg tcaacgacgg cacccgttac cagatgtgcg tgatgaagct ggaatcctgg 17520 gctcacgtgt tccgtgacta ctccgtgtcc ttccaagtgc gcctgacctt caccgaggct 17580 aacaaccaga cctacacctt ctgcacccac cccaacctga tcgtgtaagt cgacaagctt 17640 gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct 17700 ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt 17760 gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc 17820 acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta 17880 tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc 17940 ccgaaaggaa gctgagttgg ctgctgggtg cctaatgagt gagctaactc acattaattg 18000 cccggaatat taatagatca tggagataat taaaatgata accatctcgc aaataaataa 18060 gtattttact gttttcgtaa cagttttgta ataaaaaaac ctataaatat tccggattat 18120 tcataccgtc ccaccatcgg gcgcggatcc gccaccggat ccgccaccat gcgtctgtgc 18180 cgtgtgtggc tgtccgtgtg cctgtgcgct gtggtgctgg gacagtgcca gcgtgaaacc 18240 gctgagaaga acgactacta ccgtgtgccc cactactggg acgcttgctc ccgtgctctg 18300 cccgaccaga cccgttacaa gtacgtcgag cagctggtgg acctgaccct gaactaccac 18360 tacgacgctt cccacggcct ggacaacttc gacgtgctga agcgtatcaa cgtgaccgag 18420 gtgtccctgc tgatctccga cttccgtcgt cagaaccgtc gtggtggcac caacaagcgt 18480 accaccttca acgctgctgg ttccctggct ccccacgctc gttccttgga gttctccgtg 18540 cgtctgttcg ccaactaata aaagcttgtc gagaagtact agaggatcat aatcagccat 18600 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 18660 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 18720 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 18780 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 18840 cctagaagat ccggctgcta acaaagcccg aaaggaagct gagttggctg ctgccaccgc 18900 tgagcaataa ctatcataac ccccggaata ttaatagatc atggagataa ttaaaatgat 18960 aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa 19020 cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc ccggtccgaa 19080 gcgcgcggaa ttcaaaggcc taccgtcgac gccaccatgg aatcccgtat ctggtgcctg 19140 gtcgtgtgcg tgaacctgtg catcgtgtgc ctgggtgctg ctgtgtcctc ctcctccacc 19200 cgtggcacct ccgctaccca ctcccaccac tcctcccaca ccacctccgc cgctcactcc 19260 cgttccggtt ccgtgtccca gcgtgtgacc tcctcccaga ccgtgtccca cggtgtcaac 19320 gagactatct acaacaccac cctgaagtac ggcgacgtcg tgggtgtcaa caccaccaag 19380 tacccctacc gtgtgtgctc catggctcag ggcaccgacc tgatccgttt cgagcgtaac 19440 atcgtgtgca cctccatgaa gcccatcaac gaggacctgg acgagggtat catggtggtg 19500 tacaagcgca acatcgtggc tcacaccttc aaggtccgcg tgtaccagaa ggtgctgacc 19560 ttccgtcgtt cctacgctta catccacacc acttacctgc tgggttccaa caccgagtac 19620 gtggcccctc ccatgtggga gatccaccac atcaactccc actcccagtg ctactcctct 19680 tactcccgtg tgatcgctgg caccgtgttc gtggcttacc accgtgactc ctacgagaac 19740 aagaccatgc agctgatgcc cgacgactac tccaacaccc actccacccg ttacgtgacc 19800 gtgaaggacc agtggcactc ccgtggttcc acctggctgt accgtgaaac ctgcaacctg 19860 aactgcatgg tcaccatcac caccgctcgt tccaagtacc cttaccactt cttcgctacc 19920 tccaccggcg acgtggtgga catctccccc ttctacaacg gtactaaccg taacgcttcc 19980 tacttcggcg agaacgctga caagttcttc atcttcccca actacaccat cgtgtccgac 20040 ttcggtcgtc ccaactccgc tctggaaacc caccgtctgg tggctttctt ggagcgtgct 20100 gactccgtga tctcctggga catccaggac gagaagaacg tgacctgcca gctgaccttc 20160 tgggaggctt ccgagcgtac catccgttcc gaggctgagg actcctacca cttctccagc 20220 gctaagatga ccgctacctt cctgtccaag aaacaagagg tcaacatgtc cgactccgcc 20280 ctggactgcg tgcgtgacga ggctatcaac aagctgcagc agatcttcaa cacctcctac 20340 aaccagacct acgagaagta cggaaacgtg tccgtgttcg agactaccgg tggcctggtg 20400 gtgttctggc agggtatcaa gcagaagtcc ctggtcgagc tggaacgtct ggctaaccgt 20460 tcctccctga acctgaccca caaccgtacc aagcgttcca ccgacggcaa caacgctact 20520 cacctgtcca acatggaatc cgtgcacaac ctggtgtacg ctcagctgca gttcacctac 20580 gacaccctgc gcggttacat caaccgtgct ctggctcaga tcgctgaggc ttggtgcgtg 20640 gaccagcgtc gtaccctgga agtgttcaag gaactgtcca agatcaaccc ctccgctatc 20700 ctgtccgcca tctacaacaa gcctatcgct gctcgtttca tgggcgacgt gctgggcctg 20760 gcttcctgcg tgaccatcaa ccagacttcc gtgaaggtgc tgcgtgacat gaacgtgaag 20820 gaatcccccg gtcgttgcta ctcccgtccc gtggtcatct tcaacttcgc taactcctcc 20880 tacgtgcagt acggccagct gggcgaggac aacgagatcc tgctgggcaa ccaccgtacc 20940 gaggaatgcc agctgccctc cctgaagatc ttcatcgctg gcaactccgc ttacgaatac 21000 gtggactacc tgttcaagcg catgatcgac ctgtcctcca tctctaccgt ggactccatg 21060 atcgctctgg acatcgaccc cctggaaaac accgacttcc gtgtgctgga actgtactcc 21120 cagaaggaac tgcgttccat caacgtgttc gacctggaag agatcatgcg cgagttcaac 21180 tcctacaagc agcgtgttaa gtacgtcgag gacaaggtgg tggaccccct gcccccctac 21240 ctgaagggac tggacgacct gatgtccggc ctgggagctg ccggcaaggc tgtgggtgtc 21300 gctatcggtg ctgtgggtgg tgctgtggct tccgtggtcg agggtgtcgc caccttcctg 21360 aagaacccct tcggtgcttt caccatcatc ctggtggcta tcgctgtggt catcatcatc 21420 tacctgatct acacccgtca gcgtcgtctg tgcatgcagc ccctgcagaa cctgttcccc 21480 tacctggtgt ccgctgacgg tactaccgtg acctccggca acaccaagga cacctccctg 21540 caggctcccc catcctacga ggaatccgtc tacaactccg gtcgcaaggg tcccggtccc 21600 ccttcctccg acgcttctac cgctgctccc ccatacacca acgagcaggc ttaccagatg 21660 ctgctggctc tcgtgcgtct ggacgctgag cagcgtgcac agcagaacgg caccgactcc 21720 ctggacggcc agaccggaac ccaggacaag ggccagaagc ccaacctgct ggaccgtctg 21780 cgtcaccgca agaacggtta ccgtcacctg aaggactccg acgaggaaga gaacgtctaa 21840 ggcgcgccaa gcttgtcgag aagtactaga gatcataatc agccatacca catttgtaga 21900 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 21960 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 22020 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 22080 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 22140 ctgctaacaa agcccgaaag gaagctggga atattaatag atcatggaga taattaaaat 22200 gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt tgtaataaaa 22260 aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg atccgccacc 22320 atgcgtcccg gcctgccctc ctacctgatc gtgctggctg tgtgcctgct gtcccacctc 22380 ctgtcctccc gttacggtgc tgaggctatc tccgagcccc tggacaaggc tttccacctc 22440 ctgctgaaca cctacggtcg tcctatccgt ttcctgcgcg agaacaccac ccagtgcacc 22500 tacaactcct ccctgcgcaa ctccaccgtc gtccgcgaga acgctatctc cttcaacttc 22560 ttccagtcct acaaccagta ctacgtgttc cacatgcccc gttgcctgtt cgctggtccc 22620 ctggctgagc agttcctgaa ccaggtggac ctgaccgaga ctctcgagcg ttaccagcag 22680 cgtctgaaca cttacgctct ggtgtccaag gacctggctt cctaccgttc cttcagccag 22740 cagctgaagg ctcaggactc cctgggcgag cagcccacca ctgtgcctcc ccctatcgac 22800 ctgtccatcc cccacgtgtg gatgcccccc cagaccactc ctcacggctg gaccgagtcc 22860 cacaccacct ccggactgca ccgtccccac ttcaaccaga cctgcatcct gttcgacggt 22920 cacgacctgc tgttctccac cgtgaccccc tgcctgcacc agggcttcta cctcatcgac 22980 gagctgcgtt acgtgaagat caccctgacc gaggatttct tcgtggtcac cgtgtccatc 23040 gacgacgaca cccccatgct gctgatcttc ggtcacctcc cccgtgtgct gttcaaggct 23100 ccctaccagc gtgacaactt catcctgcgt cagaccgaga agcacgagct gctggtgctg 23160 gtcaagaagg accagctgaa ccgtcactct tacctgaagg accccgactt cctggacgct 23220 gctctggact tcaactacct ggacctgtcc gctctgctga ggaactcctt ccaccgttac 23280 gctgtggacg tgctgaagtc cggtcgttgc cagatgctgg accgtcgtac cgtcgagatg 23340 gctttcgctt acgccctggc tctgttcgct gctgctcgtc aagaagaggc tggcgctcag 23400 gtgtccgtgc cccgtgctct ggaccgtcag gctgctctgc tgcagatcca agagttcatg 23460 atcacttgcc tgtcccagac cccccctcgt accaccctgc tgctgtaccc caccgctgtg 23520 gacctggcta agcgtgctct gtggaccccc aaccagatca ccgacatcac ctccctcgtg 23580 cgtctggtgt acatcctgtc caagcagaac cagcagcacc tgatccccca gtgggctctg 23640 cgtcagatcg ctgacttcgc tctgaagctg cacaagaccc acctggcttc attcctcagc 23700 gctttcgctc gccaagagct gtacctgatg ggttccctgg tgcactccat gctggtgcac 23760 accaccgagc gtcgcgagat cttcatcgtg gaaaccggcc tgtgctccct ggccgagctg 23820 tcccacttca cccagctgct ggctcacccc caccacgagt acctgtccga cctgtacacc 23880 ccctgctcct cttccggtcg tcgtgaccac tccctggaac gtctgacccg tctgttcccc 23940 gacgctaccg tgcctaccac cgtgcctgct gctctgtcca tcctgtctac catgcagccc 24000 tccaccctgg aaaccttccc cgacctgttc tgcctgcctc tgggcgagtc cttctccgct 24060 ctgaccgtgt ccgagcacgt gtcctacgtg gtcaccaacc agtacctgat caagggcatc 24120 tcctaccccg tgtccaccac cgtcgtgggc cagtccctga tcatcaccca gaccgactcc 24180 cagaccaagt gcgagctgac ccgtaacatg cacaccactc actccatcac cgctgctctg 24240 aacatctccc tcgagaactg cgctttctgc cagtccgctc tgttggagta cgacgacact 24300 cagggtgtca tcaacatcat gtacatgcac gactccgacg acgtgctgtt cgctctggac 24360 ccctacaacg aggtggtggt gtcctccccc cgtacccact acctgatgct gctgaagaac 24420 ggcaccgtgc tggaagtgac cgacgtggtg gtggacgcta ccgaccgtct gctgatgatg 24480 tccgtgtacg ctctgtccgc tatcatcggc atctacctgc tgtaccgtat gctgaagacc 24540 tgctaaggcg ccaagctttg tcgagaagta ctagaggatc ataatcagcc ataccacatt 24600 tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa 24660 aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag 24720 caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt 24780 gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag 24840 atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgctgag tagtgcgcga 24900 gcaaaattta agctacaaca aggcacgcgt ccggaatatt aatagatcat ggagataatt 24960 aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa 25020 taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccc 25080 ggtccgaagc gcgcggaatt caaaggccta cgtcgacgcc accatggaat cccgtggtcg 25140 tcgttgcccc gagatgatct ccgtgctggg tcccatctcc ggtcacgtcc tgaaggctgt 25200 gttctcccgt ggcgacaccc ccgtgctgcc ccacgaaact cgtctgctgc agaccggtat 25260 ccacgtgcgt gtgtcccagc cctccctgat cctggtgtcc cagtacaccc ccgactccac 25320 cccttgccac cgcggagaca accagctgca ggtccagcac acctacttca ccggttccga 25380 ggtcgagaac gtgtccgtga acgtgcacaa ccccaccggt cgttccatct gcccctccca 25440 agagcccatg tccatctacg tgtacgctct gcccctgaag atgctgaaca tcccctccat 25500 caacgtgcac cactacccct ccgctgctga gcgcaagcac cgtcacctcc ccgtggctga 25560 cgctgtgatc cacgcttccg gcaagcagat gtggcaggct cgtctgaccg tgtccggcct 25620 ggcttggacc cgtcagcaga accagtggaa ggaacccgac gtgtactaca cctccgcttt 25680 cgtgttcccc accaaggacg tggccctgcg tcacgtcgtg tgcgctcacg aactcgtgtg 25740 ctccatggaa aacacccgtg ctaccaagat gcaagtgatc ggcgaccagt acgtgaaggt 25800 gtacctggaa tccttctgcg aggacgtgcc ctccggcaag ctgttcatgc acgtgaccct 25860 gggttccgac gtggaagagg acctgaccat gacccgtaac ccccagccct tcatgcgtcc 25920 ccacgagcgt aacggtttca ccgtgctgtg ccccaagaac atgatcatca agcccggcaa 25980 gatctcccac atcatgctgg acgtggcctt cacctcccac gagcacttcg gcctgctgtg 26040 ccctaagtcc atccccggcc tgtccatctc cggcaacctg ctgatgaacg gccagcagat 26100 cttcctggaa gtgcaggcta tccgtgaaac cgtcgagctg cgtcagtacg accctgtggc 26160 tgctctgttc ttcttcgaca tcgacctgct gctgcagcgt ggtccccagt actccgagca 26220 ccccaccttc accagccagt accgtatcca gggcaagctg gaataccgtc acacctggga 26280 ccgtcacgac gagggtgctg ctcagggcga cgacgacgtg tggacctccg gttccgactc 26340 cgacgaggaa ctggtcacca ccgagcgcaa gaccccccgt gtgaccggtg gtggtgctat 26400 ggctggtgct tccacctccg ctggtcgcaa gcgcaagtcc gcttcctccg ctaccgcttg 26460 caccgctggt gtcatgaccc gtggtcgcct gaaggctgag tccaccgtgg ctcccgaaga 26520 ggacactgac gaggactccg acaacgagat ccacaacccc gctgtgttca cctggccccc 26580 ctggcaggct ggtatcctgg ctcgtaacct ggtgcccatg gtggctaccg tgcagggcca 26640 gaacctgaag taccaagagt tcttctggga cgccaacgac atctaccgta tcttcgctga 26700 gctggaaggc gtgtggcagc ccgctgctca gcccaagcgt cgtcgtcacc gtcaggacgc 26760 tctgcctggt ccctgtatcg cttccacccc caagaagcac cgcggctaaa agcttgtcga 26820 gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa 26880 aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa 26940 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 27000 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 27060 tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa 27120 aggaagctga gttggctgct gccaccgctg agcaataact atcataaccc ctaggagatc 27180 cgaaccagat aagtgaaatc tagttccaaa ctattttgtc atttttaatt ttcgtattag 27240 cttacgacgc tacacccagt tcccatctat tttgtcactc ttccctaaat aatccttaaa 27300 aactccattt ccacccctcc cagttcccaa ctattttgtc cgcccaca 27348 <210> 59 <211> 11787 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 59 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2700 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2760 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2820 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2880 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2940 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 3000 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 3060 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 3120 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 3180 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 3240 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 3300 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 3360 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 3420 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3480 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3540 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3600 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3660 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3720 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3780 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3840 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3900 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3960 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 4020 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 4080 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 4140 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 4200 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 4260 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 4320 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 4380 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 4440 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4500 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4560 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4620 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4680 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4740 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4800 ctggaagtga ccgacgtggt ggtggacgct accgactccg gcgccggaag cggcggaggg 4860 gggtctgggg ggggaggcag ccaccaccat caccaccacc atcactaaga attcaagctt 4920 gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct 4980 ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt 5040 gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc 5100 acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta 5160 tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc 5220 ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactatcat aacccctagg 5280 ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat ccggatctga 5340 acaggaggga cagctgatag aaacagaagc cactggagca cctcaaaaac accatcatac 5400 actaaatcag taagttggca gcatcacccg acgcactttg cgccgaataa atacctgtga 5460 cggaagatca cttcgcagaa taaataaatc ctggtgtccc tgttgatacc gggaagccct 5520 gggccaactt ttggcgaaaa tgagacgttg atcggcacgt aagaggttcc aactttcacc 5580 ataatgaaat aagatcacta ccgggcgtat tttttgagtt atcgagattt tcaggagcta 5640 aggaagctaa aatggagaaa aaaatcactg gatataccac cgttgatata tcccaatggc 5700 atcgtaaaga acattttgag gcatttcagt cagttgctca atgtacctat aaccagaccg 5760 ttcagctgga tattacggcc tttttaaaga ccgtaaagaa aaataagcac aagttttatc 5820 cggcctttat tcacattctt gcccgcctga tgaatgctca tccggaattc cgtatggcaa 5880 tgaaagacgg tgagctggtg atatgggata gtgttcaccc ttgttacacc gttttccatg 5940 agcaaactga aacgttttca tcgctctgga gtgaatacca cgacgatttc cggcagtttc 6000 tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa cctggcctat ttccctaaag 6060 ggtttattga gaatatgttt ttcgtctcag ccaatccctg ggtgagtttc accagttttg 6120 atttaaacgt ggccaatatg gacaacttct tcgcccccgt tttcaccatg ggcaaatatt 6180 atacgcaagg cgacaaggtg ctgatgccgc tggcgattca ggttcatcat gccgtttgtg 6240 atggcttcca tgtcggcaga atgcttaatg aattacaaca gtactgcgat gagtggcagg 6300 gcggggcgta atttttttaa ggcagttatt ggtgccctta aacgcctggt tgctacgcct 6360 gaataagtga taataagcgg atgaatggca gaaattcgaa agcaaattcg acccggtcgt 6420 cggttcaggg cagggtcgtt aaatagccgc ttatgtctat tgctggttta ccggtttatt 6480 gactaccgga agcagtgtga ccgtgtgctt ctcaaatgcc tgaggccagt ttgctcaggc 6540 tctccccgtg gaggtaataa ttgacgatat gatcatttat tctgcctccc agctgacatt 6600 catccggggt cagcaccgtt tctgcggact ggctttctac gtgttccgct tcctttagca 6660 gcccttgcgc cctgagtgct tgcggcagcg tgaagctaat tctgtcagcc gttaagtgtt 6720 cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg ttacatccct 6780 ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat attctttttt 6840 ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat taattttatt 6900 gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag ccatgagagc 6960 ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta cgttaaacat 7020 gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt tgaactgctg 7080 atcaacagat cctctacgcg gccgcggtac cataacttcg tatagcatac attatacgaa 7140 gttatctggt ttaaacgtac ccgtagtggc tatggcaggg cttgccgccc cgacgttggc 7200 tgcgagccct gggccttcac ccgaacttgg gggttggggt ggggaaaagg aagaaacgcg 7260 ggcgtattgg tcccaatggg gtctcggtgg ggtatcgaca gagtgccagc cctgggaccg 7320 aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt tttattctgt ctttttattg 7380 ccgtcatagc gcgggttcct tccggtattg tctccttccg tgtttcagtt agcctccccc 7440 atctcccggt accgcatgct atgcatcagc tgctagctta gcgagcgtcc acagcctggg 7500 gaccgtaacg ggagtgagcg ggcaggttca cacgggtctg cttcagctca gggggcaggc 7560 cagcgtagta cttgtccagg tgacgcagca ggggggggtc cagctggtga cgcaggcaga 7620 attccttcac agcgttgtac aggccgtaga acagggtgat accctcggga gcagcagcgg 7680 tggacacggg cagacgcaca gcacggttgg tacgggtagc ctcgttacgg atagccacca 7740 ccacgttgaa cagggagggg ggcaccagct cgaaacccag cacgtgttcg gtgaagatgg 7800 aacgaccgta ggacagacga gtcaggtcgt aaccacggca caggtcgtcc acgcaagtgt 7860 acacagcggg ggaaccgtcg ccgcactcgg agtaaccgcg catcacggtc atccaacggg 7920 gagcggtgtc ggaggacagc agggtcagca gagcacgcag ctggtcgggg ttgttgtaca 7980 gcagggccag ggtgtccagg aaagcgtcgt ccagcagcac ggagttagca gcctcggggg 8040 tcacgggacg gtaacggatc agctgggaca ggggaccgtc cctacgggtc acgttgacca 8100 ggggacgcag ccaggactcg tacttgtcgc cctggaacac ctctcccagc aggcaacgac 8160 gggtcagctc ggggcactca gcgggcacct tctcagccac ggtgggagcc acggacacgg 8220 tagcggagga cacgatgggc agcagcaggc agcaccacag cagagccacg ggaccggggg 8280 agaaggagaa accgcagtcg ggacgacggc acatggtggc tcgagatccc gggtgatcaa 8340 gtcttcgtcg agtgattgta aataaaatgt aatttacagt atagtatttt aattaatata 8400 caaatgattt gataataatt cttatttaac tataatatat tgtgttgggt tgaattaaag 8460 gtccgtatac tagtatcgat tcgcgaccta ctccggaata ttaatagatc atggagataa 8520 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 8580 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 8640 cgccaccatg tcccccaaga acctgacccc cttcctgacc gctctgtggc tgctgctggg 8700 ccactcccgt gtgcctcgtg tgcgtgctga ggaatgctgc gagttcatca acgtgaacca 8760 cccccccgag cgctgctacg acttcaagat gtgcaaccgt ttcaccgtgg ctctgcgttg 8820 ccccgacggc gaagtgtgct actcccccga aaagaccgct gagatccgtg gtatcgtgac 8880 caccatgacc cactccctga cccgtcaggt ggtgcacaac aagctgacct cttgcaacta 8940 caaccccctg tacctcgagg ctgacggtcg tatccgttgc ggcaaggtca acgacaaggc 9000 tcagtacctg ctgggtgctg ctggttccgt gccctaccgt tggatcaacc tcgagtacga 9060 caagatcacc cgtatcgtgg gcctggacca gtacctcgag tccgtgaaga agcacaagcg 9120 tctggacgtg tgccgtgcta agatgggtta catgctgcag taaaagcttg tcgagaagta 9180 ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 9240 cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 9300 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 9360 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 9420 ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag 9480 ctgagttggc tgctgtggct agctttgttt aactttaaga aggagataca tctagaccgg 9540 aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt 9600 ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata 9660 ccgtcccacc atcgggcgcg gatccgccac catgctgcgt ctgctgctgc gtcaccactt 9720 ccactgcctg ctgctgtgcg ctgtgtgggc taccccctgc ctggcttccc cttggtccac 9780 cctgaccgct aaccagaacc cctccccacc ctggtccaag ctgacctact ccaagcccca 9840 cgacgctgct accttctact gccccttcct gtacccatcc ccccctcgtt ccccactgca 9900 gttctccggt ttccagcgtg tgctgaccgg tcccgagtgc cgtaacgaga ctctgtacct 9960 gctgtacaac cgcgagggcc agaccctggt cgagaggtcc tccacctggg tcaagaaggt 10020 catctggtac ttgtccggtc gtaaccagac catcctgcag cgtatgcccc gtaccgcttc 10080 caagccctcc gacggcaacg tgcagatctc cgtcgaggac gctaagatct tcggtgctca 10140 catggtgccc aagcagacca agctgctgcg tttcgtggtc aacgacggca cccgttacca 10200 gatgtgcgtg atgaagctcg agtcctgggc tcacgtgttc cgtgactact ccgtgtcctt 10260 ccaagtgcgc ctgaccttca ccgaggctaa caaccagacc tacaccttct gcacccaccc 10320 caacctgatc gtgtaaaagc ttgtcgagaa gtactagagg atcataatca gccataccac 10380 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 10440 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 10500 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 10560 tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag 10620 aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctggg tgcctaatga 10680 gtgagctaac tcacattaat tgcccggaat attaatagat catggagata attaaaatga 10740 taaccatctc gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa 10800 acctataaat attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat 10860 gcgtctgtgc cgtgtgtggc tgtccgtgtg cctgtgcgct gtggtgctgg gccagtgcca 10920 gcgtgaaacc gctgagaaga acgactacta ccgtgtgccc cactactggg acgcttgctc 10980 ccgtgctctg cccgaccaga cccgttacaa gtacgtcgag cagctggtgg acctgaccct 11040 gaactaccac tacgacgctt cccacggcct ggacaacttc gacgtgctga agcgtatcaa 11100 cgtgaccgag gtgtccctgc tgatctccga cttccgtcgt cagaaccgtc gtggtggcac 11160 caacaagcgt accaccttca acgctgctgg ttccctggct ccccacgctc gttccctcga 11220 gttctccgtg cgtctgttcg ctaactaaaa gcttgtcgag aagtactaga ggatcataat 11280 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 11340 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 11400 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 11460 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 11520 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 11580 ccaccgctga gcaataacta tcataacccc taggagatcc gaaccagata agtgaaatct 11640 agttccaaac tattttgtca tttttaattt tcgtattagc ttacgacgct acacccagtt 11700 cccatctatt ttgtcactct tccctaaata atccttaaaa actccatttc cacccctccc 11760 agttcccaac tattttgtcc gcccaca 11787 <210> 60 <211> 11848 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 60 gttgttccag tttggaacaa gagtccacta ttaaagaacg tggactccaa cgtcaaaggg 60 cgaaaaaccg tctatcaggg cgatggccca ctacgtgaac catcacccta atcaagtttt 120 ttggggtcga ggtgccgtaa agcactaaat cggaacccta aagggagccc ccgatttaga 180 gcttgacggg gaaagccggc gaacgtggcg agaaaggaag ggaagaaagc gaaaggagcg 240 ggcgctaggg cgctggcaag tgtagcggtc acgctgcgcg taaccaccac acccgccgcg 300 cttaatgcgc cgctacaggg cgcgtccatt cgccattcag gctgcgcaac tgttgggaag 360 ggcgatcggt gcgggcctct tcgctattac gccagctggc gaaaggggga tgtgctgcaa 420 ggcgattaag ttgggtaacg ccagggtttt cccagtcacg acgttgtaaa acgacggcca 480 gtgcatagac cagccgcgta acctggcaaa atcggttacg gttgagtaat aaatggatgc 540 cctgcgtaag cgggtgtggg cggacaataa agtcttaaac tgaacaaaat agatctaaac 600 tatgacaata aagtcttaaa ctagacagaa tagttgtaaa ctgaaatcag tccagttatg 660 ctgtgaaaaa gcatactgga cttttgttat ggctaaagca aactcttcat tttctgaagt 720 gcaaattgcc cgtcgtatta aagaggggcg tggccaaggg catggtaaag actatattcg 780 cggcgttgtg acaatttacc gaacaactcc gcggccggga agccgatctc ggcttgaacg 840 aattgttagg tggcggtact tgggtcgata tcaaagtgca tcacttcttc ccgtatgccc 900 aactttgtat agagagccac tgcgggatcg tcaccgtaat ctgcttgcac gtagatcaca 960 taagcaccaa gcgcgttggc ctcatgcttg aggagattga tgagcgcggt ggcaatgccc 1020 tgcctccggt gctcgccgga gactgcgaga tcatagatat agatctcact acgcggctgc 1080 tcaaacttgg gcagaacgta agccgcgaga gcgccaacaa ccgcttcttg gtcgaaggca 1140 gcaagcgcga tgaatgtctt actacggagc aagttcccga ggtaatcgga gtccggctga 1200 tgttgggagt aggtggctac gtctccgaac tcacgaccga aaagatcaag agcagcccgc 1260 atggatttga cttggtcagg gccgagccta catgtgcgaa tgatgcccat acttgagcca 1320 cctaactttg ttttagggcg actgccctgc tgcgtaacat cgttgctgct gcgtaacatc 1380 gttgctgctc cataacatca aacatcgacc cacggcgtaa cgcgcttgct gcttggatgc 1440 ccgaggcata gactgtacaa aaaaacagtc ataacaagcc atgaaaaccg ccactgcgcc 1500 gttaccaccg ctgcgttcgg tcaaggttct ggaccagttg cgtgagcgca tacgctactt 1560 gcattacagt ttacgaaccg aacaggctta tgtcaactgg gtttgtgcct tcatccgttt 1620 ccacggtgtg cgtcacccgg caaccttggg cagcagcgaa gtcgaggcat ttctgtcctg 1680 gctggcgaac gagcgcaagg tttcggtctc cacgcatcgt caggcattgg cggccttgct 1740 gttcttctac ggcaaggtgc tgtgcacgga tctgcccttg cttcaggaga tcggtagacc 1800 tcggccgtcg cggcgcttgc cggtggtgct gaccccggat gaagtggttc gcatcctcgg 1860 ttttctggaa ggcgagcatc gtttgttcgc ccaggactct agctatagtt ctagtggttg 1920 gctacagctt tgtttgtact atcaacaggt tgaactgctg atcaacagat cctctacgcg 1980 gccgcggtac cataacttcg tatagcatac attatacgaa gttatctggt ttaaacgtac 2040 ccgtagtggc tatggcaggg cttgccgccc cgacgttggc tgcgagccct gggccttcac 2100 ccgaacttgg gggttggggt ggggaaaagg aagaaacgcg ggcgtattgg tcccaatggg 2160 gtctcggtgg ggtatcgaca gagtgccagc cctgggaccg aaccccgcgt ttatgaacaa 2220 acgacccaac acccgtgcgt tttattctgt ctttttattg ccgtcatagc gcgggttcct 2280 tccggtattg tctccttccg tgtttcagtt agcctccccc atctcccggt accgcatgct 2340 atgcatcagc tgctagcacc atggctcgag atcccgggtg atcaagtctt cgtcgagtga 2400 ttgtaaataa aatgtaattt acagtatagt attttaatta atatacaaat gatttgataa 2460 taattcttat ttaactataa tatattgtgt tgggttgaat taaaggtccg tatactagta 2520 tcgattcgcg acctactccg gaatattaat agatcatgga gataattaaa atgataacca 2580 tctcgcaaat aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat 2640 aaatattccg gattattcat accgtcccac catcgggcgc ggatccgcca ccatgcgtcc 2700 cggcctgccc tcctacctga tcgtgctggc tgtgtgcctg ctgtcccacc tcctgtcctc 2760 ccgttacggt gctgaggcta tctccgagcc cctggacaag gctttccacc tcctgctgaa 2820 cacctacggt cgtcctatcc gtttcctgcg cgagaacacc acccagtgca cctacaactc 2880 ctccctgcgc aactccaccg tcgtccgcga gaacgctatc tccttcaact tcttccagtc 2940 ctacaaccag tactacgtgt tccacatgcc ccgttgcctg ttcgctggtc ccctggctga 3000 gcagttcctg aaccaggtgg acctgaccga gactctcgag cgttaccagc agcgtctgaa 3060 cacttacgct ctggtgtcca aggacctggc ttcctaccgt tccttcagcc agcagctgaa 3120 ggctcaggac tccctgggcg agcagcccac cactgtgcct ccccctatcg acctgtccat 3180 cccccacgtg tggatgcccc cccagaccac tcctcacggc tggaccgagt cccacaccac 3240 ctccggactg caccgtcccc acttcaacca gacctgcatc ctgttcgacg gtcacgacct 3300 gctgttctcc accgtgaccc cctgcctgca ccagggcttc tacctcatcg acgagctgcg 3360 ttacgtgaag atcaccctga ccgaggattt cttcgtggtc accgtgtcca tcgacgacga 3420 cacccccatg ctgctgatct tcggtcacct cccccgtgtg ctgttcaagg ctccctacca 3480 gcgtgacaac ttcatcctgc gtcagaccga gaagcacgag ctgctggtgc tggtcaagaa 3540 ggaccagctg aaccgtcact cttacctgaa ggaccccgac ttcctggacg ctgctctgga 3600 cttcaactac ctggacctgt ccgctctgct gaggaactcc ttccaccgtt acgctgtgga 3660 cgtgctgaag tccggtcgtt gccagatgct ggaccgtcgt accgtcgaga tggctttcgc 3720 ttacgccctg gctctgttcg ctgctgctcg tcaagaagag gctggcgctc aggtgtccgt 3780 gccccgtgct ctggaccgtc aggctgctct gctgcagatc caagagttca tgatcacttg 3840 cctgtcccag accccccctc gtaccaccct gctgctgtac cccaccgctg tggacctggc 3900 taagcgtgct ctgtggaccc ccaaccagat caccgacatc acctccctcg tgcgtctggt 3960 gtacatcctg tccaagcaga accagcagca cctgatcccc cagtgggctc tgcgtcagat 4020 cgctgacttc gctctgaagc tgcacaagac ccacctggct tcattcctca gcgctttcgc 4080 tcgccaagag ctgtacctga tgggttccct ggtgcactcc atgctggtgc acaccaccga 4140 gcgtcgcgag atcttcatcg tggaaaccgg cctgtgctcc ctggccgagc tgtcccactt 4200 cacccagctg ctggctcacc cccaccacga gtacctgtcc gacctgtaca ccccctgctc 4260 ctcttccggt cgtcgtgacc actccctgga acgtctgacc cgtctgttcc ccgacgctac 4320 cgtgcctacc accgtgcctg ctgctctgtc catcctgtct accatgcagc cctccaccct 4380 ggaaaccttc cccgacctgt tctgcctgcc tctgggcgag tccttctccg ctctgaccgt 4440 gtccgagcac gtgtcctacg tggtcaccaa ccagtacctg atcaagggca tctcctaccc 4500 cgtgtccacc accgtcgtgg gccagtccct gatcatcacc cagaccgact cccagaccaa 4560 gtgcgagctg acccgtaaca tgcacaccac tcactccatc accgctgctc tgaacatctc 4620 cctcgagaac tgcgctttct gccagtccgc tctgttggag tacgacgaca ctcagggtgt 4680 catcaacatc atgtacatgc acgactccga cgacgtgctg ttcgctctgg acccctacaa 4740 cgaggtggtg gtgtcctccc cccgtaccca ctacctgatg ctgctgaaga acggcaccgt 4800 gctggaagtg accgacgtgg tggtggacgc taccgactcc ggcgccctgg aagttctgtt 4860 ccaggggccc ggcggaggta gctggagcca cccgcagttc gaaaaaggaa gcggcggagg 4920 ggggtctggg gggggaggca gccaccacca tcaccaccac catcactaag aattcaagct 4980 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 5040 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 5100 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 5160 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 5220 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 5280 cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca taacccctag 5340 gggcctctaa acgggtcttg aggggttttt tgctgaaagg aggaactata tccggatctg 5400 aacaggaggg acagctgata gaaacagaag ccactggagc acctcaaaaa caccatcata 5460 cactaaatca gtaagttggc agcatcaccc gacgcacttt gcgccgaata aatacctgtg 5520 acggaagatc acttcgcaga ataaataaat cctggtgtcc ctgttgatac cgggaagccc 5580 tgggccaact tttggcgaaa atgagacgtt gatcggcacg taagaggttc caactttcac 5640 cataatgaaa taagatcact accgggcgta ttttttgagt tatcgagatt ttcaggagct 5700 aaggaagcta aaatggagaa aaaaatcact ggatatacca ccgttgatat atcccaatgg 5760 catcgtaaag aacattttga ggcatttcag tcagttgctc aatgtaccta taaccagacc 5820 gttcagctgg atattacggc ctttttaaag accgtaaaga aaaataagca caagttttat 5880 ccggccttta ttcacattct tgcccgcctg atgaatgctc atccggaatt ccgtatggca 5940 atgaaagacg gtgagctggt gatatgggat agtgttcacc cttgttacac cgttttccat 6000 gagcaaactg aaacgttttc atcgctctgg agtgaatacc acgacgattt ccggcagttt 6060 ctacacatat attcgcaaga tgtggcgtgt tacggtgaaa acctggccta tttccctaaa 6120 gggtttattg agaatatgtt tttcgtctca gccaatccct gggtgagttt caccagtttt 6180 gatttaaacg tggccaatat ggacaacttc ttcgcccccg ttttcaccat gggcaaatat 6240 tatacgcaag gcgacaaggt gctgatgccg ctggcgattc aggttcatca tgccgtttgt 6300 gatggcttcc atgtcggcag aatgcttaat gaattacaac agtactgcga tgagtggcag 6360 ggcggggcgt aattttttta aggcagttat tggtgccctt aaacgcctgg ttgctacgcc 6420 tgaataagtg ataataagcg gatgaatggc agaaattcga aagcaaattc gacccggtcg 6480 tcggttcagg gcagggtcgt taaatagccg cttatgtcta ttgctggttt accggtttat 6540 tgactaccgg aagcagtgtg accgtgtgct tctcaaatgc ctgaggccag tttgctcagg 6600 ctctccccgt ggaggtaata attgacgata tgatcattta ttctgcctcc cagctgacat 6660 tcatccgggg tcagcaccgt ttctgcggac tggctttcta cgtgttccgc ttcctttagc 6720 agcccttgcg ccctgagtgc ttgcggcagc gtgaagctaa ttctgtcagc cgttaagtgt 6780 tcctgtgtca ctcaaaattg ctttgagagg ctctaagggc ttctcagtgc gttacatccc 6840 tggcttgttg tccacaaccg ttaaacctta aaagctttaa aagccttata tattcttttt 6900 tttcttataa aacttaaaac cttagaggct atttaagttg ctgatttata ttaattttat 6960 tgttcaaaca tgagagctta gtacgtgaaa catgagagct tagtacgtta gccatgagag 7020 cttagtacgt tagccatgag ggtttagttc gttaaacatg agagcttagt acgttaaaca 7080 tgagagctta gtacgtgaaa catgagagct tagtacgtac tatcaacagg ttgaactgct 7140 gatcaacaga tcctctacgc ggccgcggta ccataacttc gtatagcata cattatacga 7200 agttatctgg tttaaacgta cccgtagtgg ctatggcagg gcttgccgcc ccgacgttgg 7260 ctgcgagccc tgggccttca cccgaacttg ggggttgggg tggggaaaag gaagaaacgc 7320 gggcgtattg gtcccaatgg ggtctcggtg gggtatcgac agagtgccag ccctgggacc 7380 gaaccccgcg tttatgaaca aacgacccaa cacccgtgcg ttttattctg tctttttatt 7440 gccgtcatag cgcgggttcc ttccggtatt gtctccttcc gtgtttcagt tagcctcccc 7500 catctcccgg taccgcatgc tatgcatcag ctgctagctt agcgagcgtc cacagcctgg 7560 ggaccgtaac gggagtgagc gggcaggttc acacgggtct gcttcagctc agggggcagg 7620 ccagcgtagt acttgtccag gtgacgcagc aggggggggt ccagctggtg acgcaggcag 7680 aattccttca cagcgttgta caggccgtag aacagggtga taccctcggg agcagcagcg 7740 gtggacacgg gcagacgcac agcacggttg gtacgggtag cctcgttacg gatagccacc 7800 accacgttga acagggaggg gggcaccagc tcgaaaccca gcacgtgttc ggtgaagatg 7860 gaacgaccgt aggacagacg agtcaggtcg taaccacggc acaggtcgtc cacgcaagtg 7920 tacacagcgg gggaaccgtc gccgcactcg gagtaaccgc gcatcacggt catccaacgg 7980 ggagcggtgt cggaggacag cagggtcagc agagcacgca gctggtcggg gttgttgtac 8040 agcagggcca gggtgtccag gaaagcgtcg tccagcagca cggagttagc agcctcgggg 8100 gtcacgggac ggtaacggat cagctgggac aggggaccgt ccctacgggt cacgttgacc 8160 aggggacgca gccaggactc gtacttgtcg ccctggaaca cctctcccag caggcaacga 8220 cgggtcagct cggggcactc agcgggcacc ttctcagcca cggtgggagc cacggacacg 8280 gtagcggagg acacgatggg cagcagcagg cagcaccaca gcagagccac gggaccgggg 8340 gagaaggaga aaccgcagtc gggacgacgg cacatggtgg ctcgagatcc cgggtgatca 8400 agtcttcgtc gagtgattgt aaataaaatg taatttacag tatagtattt taattaatat 8460 acaaatgatt tgataataat tcttatttaa ctataatata ttgtgttggg ttgaattaaa 8520 ggtccgtata ctagtatcga ttcgcgacct actccggaat attaatagat catggagata 8580 attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt aacagttttg 8640 taataaaaaa acctataaat attccggatt attcataccg tcccaccatc gggcgcggat 8700 ccgccaccat gtcccccaag aacctgaccc ccttcctgac cgctctgtgg ctgctgctgg 8760 gccactcccg tgtgcctcgt gtgcgtgctg aggaatgctg cgagttcatc aacgtgaacc 8820 acccccccga gcgctgctac gacttcaaga tgtgcaaccg tttcaccgtg gctctgcgtt 8880 gccccgacgg cgaagtgtgc tactcccccg aaaagaccgc tgagatccgt ggtatcgtga 8940 ccaccatgac ccactccctg acccgtcagg tggtgcacaa caagctgacc tcttgcaact 9000 acaaccccct gtacctcgag gctgacggtc gtatccgttg cggcaaggtc aacgacaagg 9060 ctcagtacct gctgggtgct gctggttccg tgccctaccg ttggatcaac ctcgagtacg 9120 acaagatcac ccgtatcgtg ggcctggacc agtacctcga gtccgtgaag aagcacaagc 9180 gtctggacgt gtgccgtgct aagatgggtt acatgctgca gtaaaagctt gtcgagaagt 9240 actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc 9300 tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt 9360 ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag 9420 catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg 9480 tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa 9540 gctgagttgg ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaccg 9600 gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat 9660 tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat 9720 accgtcccac catcgggcgc ggatccgcca ccatgctgcg tctgctgctg cgtcaccact 9780 tccactgcct gctgctgtgc gctgtgtggg ctaccccctg cctggcttcc ccttggtcca 9840 ccctgaccgc taaccagaac ccctccccac cctggtccaa gctgacctac tccaagcccc 9900 acgacgctgc taccttctac tgccccttcc tgtacccatc cccccctcgt tccccactgc 9960 agttctccgg tttccagcgt gtgctgaccg gtcccgagtg ccgtaacgag actctgtacc 10020 tgctgtacaa ccgcgagggc cagaccctgg tcgagaggtc ctccacctgg gtcaagaagg 10080 tcatctggta cttgtccggt cgtaaccaga ccatcctgca gcgtatgccc cgtaccgctt 10140 ccaagccctc cgacggcaac gtgcagatct ccgtcgagga cgctaagatc ttcggtgctc 10200 acatggtgcc caagcagacc aagctgctgc gtttcgtggt caacgacggc acccgttacc 10260 agatgtgcgt gatgaagctc gagtcctggg ctcacgtgtt ccgtgactac tccgtgtcct 10320 tccaagtgcg cctgaccttc accgaggcta acaaccagac ctacaccttc tgcacccacc 10380 ccaacctgat cgtgtaaaag cttgtcgaga agtactagag gatcataatc agccatacca 10440 catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac 10500 ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat 10560 aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg 10620 gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta 10680 gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgg gtgcctaatg 10740 agtgagctaa ctcacattaa ttgcccggaa tattaataga tcatggagat aattaaaatg 10800 ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa 10860 aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccacca 10920 tgcgtctgtg ccgtgtgtgg ctgtccgtgt gcctgtgcgc tgtggtgctg ggccagtgcc 10980 agcgtgaaac cgctgagaag aacgactact accgtgtgcc ccactactgg gacgcttgct 11040 cccgtgctct gcccgaccag acccgttaca agtacgtcga gcagctggtg gacctgaccc 11100 tgaactacca ctacgacgct tcccacggcc tggacaactt cgacgtgctg aagcgtatca 11160 acgtgaccga ggtgtccctg ctgatctccg acttccgtcg tcagaaccgt cgtggtggca 11220 ccaacaagcg taccaccttc aacgctgctg gttccctggc tccccacgct cgttccctcg 11280 agttctccgt gcgtctgttc gctaactaaa agcttgtcga gaagtactag aggatcataa 11340 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 11400 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 11460 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 11520 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atctgatcac 11580 tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa aggaagctga gttggctgct 11640 gccaccgctg agcaataact atcataaccc ctaggagatc cgaaccagat aagtgaaatc 11700 tagttccaaa ctattttgtc atttttaatt ttcgtattag cttacgacgc tacacccagt 11760 tcccatctat tttgtcactc ttccctaaat aatccttaaa aactccattt ccacccctcc 11820 cagttcccaa ctattttgtc cgcccaca 11848 <210> 61 <211> 11811 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 61 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2700 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2760 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2820 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2880 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2940 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 3000 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 3060 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 3120 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 3180 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 3240 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 3300 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 3360 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 3420 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3480 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3540 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3600 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3660 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3720 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3780 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3840 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3900 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3960 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 4020 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 4080 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 4140 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 4200 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 4260 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 4320 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 4380 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 4440 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4500 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4560 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4620 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4680 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4740 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4800 ctggaagtga ccgacgtggt ggtggacgct accgactccg gcgccctgga agttctgttc 4860 caggggcccg gaagcggcgg aggggggtct ggggggggag gcagccacca ccatcaccac 4920 caccatcact aagaattcaa gcttgtcgag aagtactaga ggatcataat cagccatacc 4980 acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa 5040 cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa 5100 taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt 5160 ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact gcttgagcct 5220 agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ccaccgctga 5280 gcaataacta tcataacccc taggggcctc taaacgggtc ttgaggggtt ttttgctgaa 5340 aggaggaact atatccggat ctgaacagga gggacagctg atagaaacag aagccactgg 5400 agcacctcaa aaacaccatc atacactaaa tcagtaagtt ggcagcatca cccgacgcac 5460 tttgcgccga ataaatacct gtgacggaag atcacttcgc agaataaata aatcctggtg 5520 tccctgttga taccgggaag ccctgggcca acttttggcg aaaatgagac gttgatcggc 5580 acgtaagagg ttccaacttt caccataatg aaataagatc actaccgggc gtattttttg 5640 agttatcgag attttcagga gctaaggaag ctaaaatgga gaaaaaaatc actggatata 5700 ccaccgttga tatatcccaa tggcatcgta aagaacattt tgaggcattt cagtcagttg 5760 ctcaatgtac ctataaccag accgttcagc tggatattac ggccttttta aagaccgtaa 5820 agaaaaataa gcacaagttt tatccggcct ttattcacat tcttgcccgc ctgatgaatg 5880 ctcatccgga attccgtatg gcaatgaaag acggtgagct ggtgatatgg gatagtgttc 5940 acccttgtta caccgttttc catgagcaaa ctgaaacgtt ttcatcgctc tggagtgaat 6000 accacgacga tttccggcag tttctacaca tatattcgca agatgtggcg tgttacggtg 6060 aaaacctggc ctatttccct aaagggttta ttgagaatat gtttttcgtc tcagccaatc 6120 cctgggtgag tttcaccagt tttgatttaa acgtggccaa tatggacaac ttcttcgccc 6180 ccgttttcac catgggcaaa tattatacgc aaggcgacaa ggtgctgatg ccgctggcga 6240 ttcaggttca tcatgccgtt tgtgatggct tccatgtcgg cagaatgctt aatgaattac 6300 aacagtactg cgatgagtgg cagggcgggg cgtaattttt ttaaggcagt tattggtgcc 6360 cttaaacgcc tggttgctac gcctgaataa gtgataataa gcggatgaat ggcagaaatt 6420 cgaaagcaaa ttcgacccgg tcgtcggttc agggcagggt cgttaaatag ccgcttatgt 6480 ctattgctgg tttaccggtt tattgactac cggaagcagt gtgaccgtgt gcttctcaaa 6540 tgcctgaggc cagtttgctc aggctctccc cgtggaggta ataattgacg atatgatcat 6600 ttattctgcc tcccagctga cattcatccg gggtcagcac cgtttctgcg gactggcttt 6660 ctacgtgttc cgcttccttt agcagccctt gcgccctgag tgcttgcggc agcgtgaagc 6720 taattctgtc agccgttaag tgttcctgtg tcactcaaaa ttgctttgag aggctctaag 6780 ggcttctcag tgcgttacat ccctggcttg ttgtccacaa ccgttaaacc ttaaaagctt 6840 taaaagcctt atatattctt ttttttctta taaaacttaa aaccttagag gctatttaag 6900 ttgctgattt atattaattt tattgttcaa acatgagagc ttagtacgtg aaacatgaga 6960 gcttagtacg ttagccatga gagcttagta cgttagccat gagggtttag ttcgttaaac 7020 atgagagctt agtacgttaa acatgagagc ttagtacgtg aaacatgaga gcttagtacg 7080 tactatcaac aggttgaact gctgatcaac agatcctcta cgcggccgcg gtaccataac 7140 ttcgtatagc atacattata cgaagttatc tggtttaaac gtacccgtag tggctatggc 7200 agggcttgcc gccccgacgt tggctgcgag ccctgggcct tcacccgaac ttgggggttg 7260 gggtggggaa aaggaagaaa cgcgggcgta ttggtcccaa tggggtctcg gtggggtatc 7320 gacagagtgc cagccctggg accgaacccc gcgtttatga acaaacgacc caacacccgt 7380 gcgttttatt ctgtcttttt attgccgtca tagcgcgggt tccttccggt attgtctcct 7440 tccgtgtttc agttagcctc ccccatctcc cggtaccgca tgctatgcat cagctgctag 7500 cttagcgagc gtccacagcc tggggaccgt aacgggagtg agcgggcagg ttcacacggg 7560 tctgcttcag ctcagggggc aggccagcgt agtacttgtc caggtgacgc agcagggggg 7620 ggtccagctg gtgacgcagg cagaattcct tcacagcgtt gtacaggccg tagaacaggg 7680 tgataccctc gggagcagca gcggtggaca cgggcagacg cacagcacgg ttggtacggg 7740 tagcctcgtt acggatagcc accaccacgt tgaacaggga ggggggcacc agctcgaaac 7800 ccagcacgtg ttcggtgaag atggaacgac cgtaggacag acgagtcagg tcgtaaccac 7860 ggcacaggtc gtccacgcaa gtgtacacag cgggggaacc gtcgccgcac tcggagtaac 7920 cgcgcatcac ggtcatccaa cggggagcgg tgtcggagga cagcagggtc agcagagcac 7980 gcagctggtc ggggttgttg tacagcaggg ccagggtgtc caggaaagcg tcgtccagca 8040 gcacggagtt agcagcctcg ggggtcacgg gacggtaacg gatcagctgg gacaggggac 8100 cgtccctacg ggtcacgttg accaggggac gcagccagga ctcgtacttg tcgccctgga 8160 acacctctcc cagcaggcaa cgacgggtca gctcggggca ctcagcgggc accttctcag 8220 ccacggtggg agccacggac acggtagcgg aggacacgat gggcagcagc aggcagcacc 8280 acagcagagc cacgggaccg ggggagaagg agaaaccgca gtcgggacga cggcacatgg 8340 tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat tgtaaataaa atgtaattta 8400 cagtatagta ttttaattaa tatacaaatg atttgataat aattcttatt taactataat 8460 atattgtgtt gggttgaatt aaaggtccgt atactagtat cgattcgcga cctactccgg 8520 aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt 8580 ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata 8640 ccgtcccacc atcgggcgcg gatccgccac catgtccccc aagaacctga cccccttcct 8700 gaccgctctg tggctgctgc tgggccactc ccgtgtgcct cgtgtgcgtg ctgaggaatg 8760 ctgcgagttc atcaacgtga accacccccc cgagcgctgc tacgacttca agatgtgcaa 8820 ccgtttcacc gtggctctgc gttgccccga cggcgaagtg tgctactccc ccgaaaagac 8880 cgctgagatc cgtggtatcg tgaccaccat gacccactcc ctgacccgtc aggtggtgca 8940 caacaagctg acctcttgca actacaaccc cctgtacctc gaggctgacg gtcgtatccg 9000 ttgcggcaag gtcaacgaca aggctcagta cctgctgggt gctgctggtt ccgtgcccta 9060 ccgttggatc aacctcgagt acgacaagat cacccgtatc gtgggcctgg accagtacct 9120 cgagtccgtg aagaagcaca agcgtctgga cgtgtgccgt gctaagatgg gttacatgct 9180 gcagtaaaag cttgtcgaga agtactagag gatcataatc agccatacca catttgtaga 9240 ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa 9300 tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag 9360 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 9420 actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta gaagatccgg 9480 ctgctaacaa agcccgaaag gaagctgagt tggctgctgt ggctagcttt gtttaacttt 9540 aagaaggaga tacatctaga ccggaatatt aatagatcat ggagataatt aaaatgataa 9600 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 9660 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgct 9720 gcgtctgctg ctgcgtcacc acttccactg cctgctgctg tgcgctgtgt gggctacccc 9780 ctgcctggct tccccttggt ccaccctgac cgctaaccag aacccctccc caccctggtc 9840 caagctgacc tactccaagc cccacgacgc tgctaccttc tactgcccct tcctgtaccc 9900 atccccccct cgttccccac tgcagttctc cggtttccag cgtgtgctga ccggtcccga 9960 gtgccgtaac gagactctgt acctgctgta caaccgcgag ggccagaccc tggtcgagag 10020 gtcctccacc tgggtcaaga aggtcatctg gtacttgtcc ggtcgtaacc agaccatcct 10080 gcagcgtatg ccccgtaccg cttccaagcc ctccgacggc aacgtgcaga tctccgtcga 10140 ggacgctaag atcttcggtg ctcacatggt gcccaagcag accaagctgc tgcgtttcgt 10200 ggtcaacgac ggcacccgtt accagatgtg cgtgatgaag ctcgagtcct gggctcacgt 10260 gttccgtgac tactccgtgt ccttccaagt gcgcctgacc ttcaccgagg ctaacaacca 10320 gacctacacc ttctgcaccc accccaacct gatcgtgtaa aagcttgtcg agaagtacta 10380 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 10440 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 10500 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 10560 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 10620 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 10680 agttggctgc tgggtgccta atgagtgagc taactcacat taattgcccg gaatattaat 10740 agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt 10800 tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac 10860 catcgggcgc ggatccgcca ccatgcgtct gtgccgtgtg tggctgtccg tgtgcctgtg 10920 cgctgtggtg ctgggccagt gccagcgtga aaccgctgag aagaacgact actaccgtgt 10980 gccccactac tgggacgctt gctcccgtgc tctgcccgac cagacccgtt acaagtacgt 11040 cgagcagctg gtggacctga ccctgaacta ccactacgac gcttcccacg gcctggacaa 11100 cttcgacgtg ctgaagcgta tcaacgtgac cgaggtgtcc ctgctgatct ccgacttccg 11160 tcgtcagaac cgtcgtggtg gcaccaacaa gcgtaccacc ttcaacgctg ctggttccct 11220 ggctccccac gctcgttccc tcgagttctc cgtgcgtctg ttcgctaact aaaagcttgt 11280 cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt 11340 aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt 11400 taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 11460 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 11520 ttatcatgtc tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc 11580 gaaaggaagc tgagttggct gctgccaccg ctgagcaata actatcataa cccctaggag 11640 atccgaacca gataagtgaa atctagttcc aaactatttt gtcattttta attttcgtat 11700 tagcttacga cgctacaccc agttcccatc tattttgtca ctcttcccta aataatcctt 11760 aaaaactcca tttccacccc tcccagttcc caactatttt gtccgcccac a 11811 <210> 62 <211> 11841 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 62 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catgcgtccc 2700 ggcctgccct cctacctgat cgtgctggct gtgtgcctgc tgtcccacct cctgtcctcc 2760 cgttacggtg ctgaggctat ctccgagccc ctggacaagg ctttccacct cctgctgaac 2820 acctacggtc gtcctatccg tttcctgcgc gagaacacca cccagtgcac ctacaactcc 2880 tccctgcgca actccaccgt cgtccgcgag aacgctatct ccttcaactt cttccagtcc 2940 tacaaccagt actacgtgtt ccacatgccc cgttgcctgt tcgctggtcc cctggctgag 3000 cagttcctga accaggtgga cctgaccgag actctcgagc gttaccagca gcgtctgaac 3060 acttacgctc tggtgtccaa ggacctggct tcctaccgtt ccttcagcca gcagctgaag 3120 gctcaggact ccctgggcga gcagcccacc actgtgcctc cccctatcga cctgtccatc 3180 ccccacgtgt ggatgccccc ccagaccact cctcacggct ggaccgagtc ccacaccacc 3240 tccggactgc accgtcccca cttcaaccag acctgcatcc tgttcgacgg tcacgacctg 3300 ctgttctcca ccgtgacccc ctgcctgcac cagggcttct acctcatcga cgagctgcgt 3360 tacgtgaaga tcaccctgac cgaggatttc ttcgtggtca ccgtgtccat cgacgacgac 3420 acccccatgc tgctgatctt cggtcacctc ccccgtgtgc tgttcaaggc tccctaccag 3480 cgtgacaact tcatcctgcg tcagaccgag aagcacgagc tgctggtgct ggtcaagaag 3540 gaccagctga accgtcactc ttacctgaag gaccccgact tcctggacgc tgctctggac 3600 ttcaactacc tggacctgtc cgctctgctg aggaactcct tccaccgtta cgctgtggac 3660 gtgctgaagt ccggtcgttg ccagatgctg gaccgtcgta ccgtcgagat ggctttcgct 3720 tacgccctgg ctctgttcgc tgctgctcgt caagaagagg ctggcgctca ggtgtccgtg 3780 ccccgtgctc tggaccgtca ggctgctctg ctgcagatcc aagagttcat gatcacttgc 3840 ctgtcccaga ccccccctcg taccaccctg ctgctgtacc ccaccgctgt ggacctggct 3900 aagcgtgctc tgtggacccc caaccagatc accgacatca cctccctcgt gcgtctggtg 3960 tacatcctgt ccaagcagaa ccagcagcac ctgatccccc agtgggctct gcgtcagatc 4020 gctgacttcg ctctgaagct gcacaagacc cacctggctt cattcctcag cgctttcgct 4080 cgccaagagc tgtacctgat gggttccctg gtgcactcca tgctggtgca caccaccgag 4140 cgtcgcgaga tcttcatcgt ggaaaccggc ctgtgctccc tggccgagct gtcccacttc 4200 acccagctgc tggctcaccc ccaccacgag tacctgtccg acctgtacac cccctgctcc 4260 tcttccggtc gtcgtgacca ctccctggaa cgtctgaccc gtctgttccc cgacgctacc 4320 gtgcctacca ccgtgcctgc tgctctgtcc atcctgtcta ccatgcagcc ctccaccctg 4380 gaaaccttcc ccgacctgtt ctgcctgcct ctgggcgagt ccttctccgc tctgaccgtg 4440 tccgagcacg tgtcctacgt ggtcaccaac cagtacctga tcaagggcat ctcctacccc 4500 gtgtccacca ccgtcgtggg ccagtccctg atcatcaccc agaccgactc ccagaccaag 4560 tgcgagctga cccgtaacat gcacaccact cactccatca ccgctgctct gaacatctcc 4620 ctcgagaact gcgctttctg ccagtccgct ctgttggagt acgacgacac tcagggtgtc 4680 atcaacatca tgtacatgca cgactccgac gacgtgctgt tcgctctgga cccctacaac 4740 gaggtggtgg tgtcctcccc ccgtacccac tacctgatgc tgctgaagaa cggcaccgtg 4800 ctggaagtga ccgacgtggt ggtggacgct accgactccg gcgccctgga agttctgttc 4860 caggggcccc cggtccgaga gaacctgtac ttccaaggcg gaagcggcgg aggggggtct 4920 ggggggggag gcagccacca ccatcaccac caccatcact aagaattcaa gcttgtcgag 4980 aagtactaga ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa 5040 aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac 5100 ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 5160 aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat 5220 catgtctgga tctgatcact gcttgagcct agaagatccg gctgctaaca aagcccgaaa 5280 ggaagctgag ttggctgctg ccaccgctga gcaataacta tcataacccc taggggcctc 5340 taaacgggtc ttgaggggtt ttttgctgaa aggaggaact atatccggat ctgaacagga 5400 gggacagctg atagaaacag aagccactgg agcacctcaa aaacaccatc atacactaaa 5460 tcagtaagtt ggcagcatca cccgacgcac tttgcgccga ataaatacct gtgacggaag 5520 atcacttcgc agaataaata aatcctggtg tccctgttga taccgggaag ccctgggcca 5580 acttttggcg aaaatgagac gttgatcggc acgtaagagg ttccaacttt caccataatg 5640 aaataagatc actaccgggc gtattttttg agttatcgag attttcagga gctaaggaag 5700 ctaaaatgga gaaaaaaatc actggatata ccaccgttga tatatcccaa tggcatcgta 5760 aagaacattt tgaggcattt cagtcagttg ctcaatgtac ctataaccag accgttcagc 5820 tggatattac ggccttttta aagaccgtaa agaaaaataa gcacaagttt tatccggcct 5880 ttattcacat tcttgcccgc ctgatgaatg ctcatccgga attccgtatg gcaatgaaag 5940 acggtgagct ggtgatatgg gatagtgttc acccttgtta caccgttttc catgagcaaa 6000 ctgaaacgtt ttcatcgctc tggagtgaat accacgacga tttccggcag tttctacaca 6060 tatattcgca agatgtggcg tgttacggtg aaaacctggc ctatttccct aaagggttta 6120 ttgagaatat gtttttcgtc tcagccaatc cctgggtgag tttcaccagt tttgatttaa 6180 acgtggccaa tatggacaac ttcttcgccc ccgttttcac catgggcaaa tattatacgc 6240 aaggcgacaa ggtgctgatg ccgctggcga ttcaggttca tcatgccgtt tgtgatggct 6300 tccatgtcgg cagaatgctt aatgaattac aacagtactg cgatgagtgg cagggcgggg 6360 cgtaattttt ttaaggcagt tattggtgcc cttaaacgcc tggttgctac gcctgaataa 6420 gtgataataa gcggatgaat ggcagaaatt cgaaagcaaa ttcgacccgg tcgtcggttc 6480 agggcagggt cgttaaatag ccgcttatgt ctattgctgg tttaccggtt tattgactac 6540 cggaagcagt gtgaccgtgt gcttctcaaa tgcctgaggc cagtttgctc aggctctccc 6600 cgtggaggta ataattgacg atatgatcat ttattctgcc tcccagctga cattcatccg 6660 gggtcagcac cgtttctgcg gactggcttt ctacgtgttc cgcttccttt agcagccctt 6720 gcgccctgag tgcttgcggc agcgtgaagc taattctgtc agccgttaag tgttcctgtg 6780 tcactcaaaa ttgctttgag aggctctaag ggcttctcag tgcgttacat ccctggcttg 6840 ttgtccacaa ccgttaaacc ttaaaagctt taaaagcctt atatattctt ttttttctta 6900 taaaacttaa aaccttagag gctatttaag ttgctgattt atattaattt tattgttcaa 6960 acatgagagc ttagtacgtg aaacatgaga gcttagtacg ttagccatga gagcttagta 7020 cgttagccat gagggtttag ttcgttaaac atgagagctt agtacgttaa acatgagagc 7080 ttagtacgtg aaacatgaga gcttagtacg tactatcaac aggttgaact gctgatcaac 7140 agatcctcta cgcggccgcg gtaccataac ttcgtatagc atacattata cgaagttatc 7200 tggtttaaac gtacccgtag tggctatggc agggcttgcc gccccgacgt tggctgcgag 7260 ccctgggcct tcacccgaac ttgggggttg gggtggggaa aaggaagaaa cgcgggcgta 7320 ttggtcccaa tggggtctcg gtggggtatc gacagagtgc cagccctggg accgaacccc 7380 gcgtttatga acaaacgacc caacacccgt gcgttttatt ctgtcttttt attgccgtca 7440 tagcgcgggt tccttccggt attgtctcct tccgtgtttc agttagcctc ccccatctcc 7500 cggtaccgca tgctatgcat cagctgctag cttagcgagc gtccacagcc tggggaccgt 7560 aacgggagtg agcgggcagg ttcacacggg tctgcttcag ctcagggggc aggccagcgt 7620 agtacttgtc caggtgacgc agcagggggg ggtccagctg gtgacgcagg cagaattcct 7680 tcacagcgtt gtacaggccg tagaacaggg tgataccctc gggagcagca gcggtggaca 7740 cgggcagacg cacagcacgg ttggtacggg tagcctcgtt acggatagcc accaccacgt 7800 tgaacaggga ggggggcacc agctcgaaac ccagcacgtg ttcggtgaag atggaacgac 7860 cgtaggacag acgagtcagg tcgtaaccac ggcacaggtc gtccacgcaa gtgtacacag 7920 cgggggaacc gtcgccgcac tcggagtaac cgcgcatcac ggtcatccaa cggggagcgg 7980 tgtcggagga cagcagggtc agcagagcac gcagctggtc ggggttgttg tacagcaggg 8040 ccagggtgtc caggaaagcg tcgtccagca gcacggagtt agcagcctcg ggggtcacgg 8100 gacggtaacg gatcagctgg gacaggggac cgtccctacg ggtcacgttg accaggggac 8160 gcagccagga ctcgtacttg tcgccctgga acacctctcc cagcaggcaa cgacgggtca 8220 gctcggggca ctcagcgggc accttctcag ccacggtggg agccacggac acggtagcgg 8280 aggacacgat gggcagcagc aggcagcacc acagcagagc cacgggaccg ggggagaagg 8340 agaaaccgca gtcgggacga cggcacatgg tggctcgaga tcccgggtga tcaagtcttc 8400 gtcgagtgat tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg 8460 atttgataat aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt 8520 atactagtat cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa 8580 tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa 8640 aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac 8700 catgtccccc aagaacctga cccccttcct gaccgctctg tggctgctgc tgggccactc 8760 ccgtgtgcct cgtgtgcgtg ctgaggaatg ctgcgagttc atcaacgtga accacccccc 8820 cgagcgctgc tacgacttca agatgtgcaa ccgtttcacc gtggctctgc gttgccccga 8880 cggcgaagtg tgctactccc ccgaaaagac cgctgagatc cgtggtatcg tgaccaccat 8940 gacccactcc ctgacccgtc aggtggtgca caacaagctg acctcttgca actacaaccc 9000 cctgtacctc gaggctgacg gtcgtatccg ttgcggcaag gtcaacgaca aggctcagta 9060 cctgctgggt gctgctggtt ccgtgcccta ccgttggatc aacctcgagt acgacaagat 9120 cacccgtatc gtgggcctgg accagtacct cgagtccgtg aagaagcaca agcgtctgga 9180 cgtgtgccgt gctaagatgg gttacatgct gcagtaaaag cttgtcgaga agtactagag 9240 gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca 9300 cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc 9360 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 9420 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat 9480 ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt 9540 tggctgctgt ggctagcttt gtttaacttt aagaaggaga tacatctaga ccggaatatt 9600 aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg 9660 ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc 9720 caccatcggg cgcggatccg ccaccatgct gcgtctgctg ctgcgtcacc acttccactg 9780 cctgctgctg tgcgctgtgt gggctacccc ctgcctggct tccccttggt ccaccctgac 9840 cgctaaccag aacccctccc caccctggtc caagctgacc tactccaagc cccacgacgc 9900 tgctaccttc tactgcccct tcctgtaccc atccccccct cgttccccac tgcagttctc 9960 cggtttccag cgtgtgctga ccggtcccga gtgccgtaac gagactctgt acctgctgta 10020 caaccgcgag ggccagaccc tggtcgagag gtcctccacc tgggtcaaga aggtcatctg 10080 gtacttgtcc ggtcgtaacc agaccatcct gcagcgtatg ccccgtaccg cttccaagcc 10140 ctccgacggc aacgtgcaga tctccgtcga ggacgctaag atcttcggtg ctcacatggt 10200 gcccaagcag accaagctgc tgcgtttcgt ggtcaacgac ggcacccgtt accagatgtg 10260 cgtgatgaag ctcgagtcct gggctcacgt gttccgtgac tactccgtgt ccttccaagt 10320 gcgcctgacc ttcaccgagg ctaacaacca gacctacacc ttctgcaccc accccaacct 10380 gatcgtgtaa aagcttgtcg agaagtacta gaggatcata atcagccata ccacatttgt 10440 agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 10500 gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 10560 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 10620 caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctagaagatc 10680 cggctgctaa caaagcccga aaggaagctg agttggctgc tgggtgccta atgagtgagc 10740 taactcacat taattgcccg gaatattaat agatcatgga gataattaaa atgataacca 10800 tctcgcaaat aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat 10860 aaatattccg gattattcat accgtcccac catcgggcgc ggatccgcca ccatgcgtct 10920 gtgccgtgtg tggctgtccg tgtgcctgtg cgctgtggtg ctgggccagt gccagcgtga 10980 aaccgctgag aagaacgact actaccgtgt gccccactac tgggacgctt gctcccgtgc 11040 tctgcccgac cagacccgtt acaagtacgt cgagcagctg gtggacctga ccctgaacta 11100 ccactacgac gcttcccacg gcctggacaa cttcgacgtg ctgaagcgta tcaacgtgac 11160 cgaggtgtcc ctgctgatct ccgacttccg tcgtcagaac cgtcgtggtg gcaccaacaa 11220 gcgtaccacc ttcaacgctg ctggttccct ggctccccac gctcgttccc tcgagttctc 11280 cgtgcgtctg ttcgctaact aaaagcttgt cgagaagtac tagaggatca taatcagcca 11340 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 11400 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 11460 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 11520 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga 11580 gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgccaccg 11640 ctgagcaata actatcataa cccctaggag atccgaacca gataagtgaa atctagttcc 11700 aaactatttt gtcattttta attttcgtat tagcttacga cgctacaccc agttcccatc 11760 tattttgtca ctcttcccta aataatcctt aaaaactcca tttccacccc tcccagttcc 11820 caactatttt gtccgcccac a 11841 <210> 63 <211> 26 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 63 tgatttgata ataattctta tttaac 26 <210> 64 <211> 40 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 64 ggctagcttt gtttaacttt aagaaggaga tacatctaga 40 <210> 65 <211> 57 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 65 tgctgcccac cgctgagcaa taactatcat aacccccgga atattaatag atcatgg 57 <210> 66 <211> 21 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 66 gtagcgtcgt aagctaatac g 21 <210> 67 <211> 8806 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 67 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaaat attaatagat 7200 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 7260 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 7320 gggcgcggat ccgccaccat ggctgctatg gaagctaaca tcttctgcac cttcgaccac 7380 aagctgtcta tcgctgacgt gggcaagctg accaagctgg tggctgctgt ggtgcccatc 7440 ccccagcgtc tgcacctgat caagcactac cagctgggcc tgcaccagtt cgtggaccac 7500 acccgtggtt acgtgcgtct gcgtggcctg ctgcgtaaca tgaccctgac cctgatgcgt 7560 cgtgtcgagg gcaaccagat cctgctgcac gtgcccaccc acggcctgct gtacaccgtg 7620 ctgaacaccg gtcccgtgac ctgggagaag ggcgacgctc tgtgcgtgct gccccccctg 7680 ttccacggtc ccctggctcg tgaaaacctg ttgaccctgg gccagtggga gctggtgctg 7740 ccctggatcg tgcccatgcc cctggctctg gaaatcaacc agcgcctgct gatcatgggc 7800 ctgttctccc tggaccgttc ctacgaagaa gtgaaggctg ctgtccagca gctgcagacc 7860 atcaccttcc gtgacgctac cttcaccatc cccgaccccg tgatcgacca gcacctcctg 7920 atcgacatga agaccgcttg cctgtccatg tccatggtgg ctaacctggc ttccgagctg 7980 accatgacct acgtccgcaa gctggctttg gaggactctt ccatgctgct ggtcaagtgc 8040 caagagctgc tgatgcgtct ggaccgcgag cgttccgtgg gcgagcctcg tactcccgct 8100 cgtcctcagc acgtgtcccc cgacgacgag atcgctcgtc tgtccgctct gttcgtgatg 8160 ctgcgtcagc tggacgacct gatccgcgag caggtcgtgt tcaccgtgtg cgacgtgagc 8220 ccagacaaca agtccgctac ctgcatcttc aagggctaag gcgcgccaag cttgtcgaga 8280 agtactagag gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa 8340 acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact 8400 tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 8460 aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc 8520 atgtctggat ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag 8580 gaagctgagt tggctgctgc caccgctgag caataactat cataacccct aggagatccg 8640 aaccagataa gtgaaatcta gttccaaact attttgtcat ttttaatttt cgtattagct 8700 tacgacgcta cacccagttc ccatctattt tgtcactctt ccctaaataa tccttaaaaa 8760 ctccatttcc acccctccca gttcccaact attttgtccg cccaca 8806 <210> 68 <211> 14082 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 68 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttatcaatag cctttggtgg tggttgcagt aaagttctgg 2400 aaacagcaat gtcgtagtac gatacaaaaa gctcccatga gaatgagagc attaagcata 2460 gtccaccagg ccgcaaagct ggacagagaa agttcataca tatgcgatgt acaatgcgcc 2520 ttgtaaaaat cattgtgagc atgtggtctc atcacattgg ggtcgtgagt ggtggaaccg 2580 ggtttggtac tagtcgttga tgaagtcgta cttgtcaccg tagttgtact agttgtcgca 2640 gtagtcgttg ccttcacggt cgttgaggtg tgagtagagc tagagggact cggtgtgcta 2700 gcagtcgacg tatggttgga acttgccgct accgataaaa ccaaaagacc tagtactagt 2760 gtgttccact ccatggtggc ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 2820 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 2880 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 2940 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 3000 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 3060 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat ggaaaactgg 3120 tccgctctgg aactgctgcc caaggtcgga atccctaccg acttcctgac ccacgtcaag 3180 acctccgctg gcgaggaaat gttcgaggct ctgaggatct actacggcga cgaccccgag 3240 cgttacaaca tccacttcga ggctatcttc ggcaccttct gcaaccgtct ggaatgggtg 3300 tacttcctga cttccggcct ggctgctgct gctcacgcta tcaagttcca cgacctgaac 3360 aagctgacca ccggcaagat gctgttccac gtgcaagtgc cccgtgtggc ttccggtgct 3420 ggcctgccta cctcccgtca gaccaccatc atggtcacca agtactccga gaagtccccc 3480 atcaccatcc ctttcgagct gtccgctgct tgcctgactt acctgcgtga aaccttcgag 3540 ggcaccatcc tggacaagat cctgaacgtc gaggctatgc acaccgtgct gcgtgctctg 3600 aagaacaccg ctgacgctat ggaacgtggc ctgatccaca gcttcctcca gaccctgctg 3660 aggaaggctc ccccctactt cgtggtgcag accctggtcg agaacgctac cctggctcgt 3720 caggctctga accgtatcca gcgctccaac atcctgcagt ccttcaaggc taagatgctg 3780 gctaccctgt tcctgctgaa ccgtacccgt gaccgtgact acgtgctgaa gttcctgacc 3840 cgtctggctg aggctgctac cgactccatc ctcgacaacc ctactaccta caccacctcc 3900 tccggtgcta agatctccgg tgtcatggtg tccaccgcta acgtgatgca gatcatcatg 3960 tccctgctgt cctcccacat cactaaggaa accgtgtccg ctcccgctac ctacggcaac 4020 ttcgtgctgt cccccgagaa cgctgtgacc gctatctcct accactctat cctggctgac 4080 ttcaactcct acaaggctca cctgacctcc ggccagcccc acctccccaa cgactccctg 4140 agccaggctg gtgctcactc cctgaccccc ctgtccatgg acgtgatccg tctgggcgaa 4200 aagaccgtga tcatggaaaa cctgcgtcgc gtgtacaaga acaccgacac caaggacccc 4260 ctggaacgta acgtggacct gaccttcttc ttccccgtgg gcctgtacct gcccgaggac 4320 cgtggttaca ccaccgtcga gtccaaggtc aagctgaacg acaccgtgcg taacgctctg 4380 cccaccaccg cttacctgct gaacagggac cgtgctgtgc aaaagatcga cttcgtggac 4440 gctctcaaga ccctgtgcca ccccgtgctg cacgagcctg ctccatgcct gcaggctttc 4500 accgagcgtg gtcccccatc cgagcccgct atgcagcgtc tgctggaatg ccgtttccag 4560 caagagccca tgggtggtgc tgctcgtcgt atcccccact tctaccgtgt gcgccgcgag 4620 gtgccccgta ccgtgaacga gatgaagcag gacttcgtgg tcaccgactt ctacaaggtt 4680 ggaaacatca ccctgtacac cgagctgcac cctttcttcg acttcaccca ctgccaagag 4740 aactccgaga ctgtggctct gtgcaccccc cgtatcgtga tcggcaacct gcccgacggc 4800 ctggctcccg gtcccttcca cgagctgagg acctgggaga tcatggaaca catgcgcctg 4860 cgtcccccac ccgactacga ggaaaccctg cgtctgttca agaccaccgt gacctccccc 4920 aactaccccg agctgtgcta cctggtggac gtgctggtgc acggcaacgc tgacgctttc 4980 ctgctgatcc gcgctttcat cgctcgttgc atcgtgaaca tgttccacac ccgtcagctg 5040 ctggtgttcg ctcactccta cgctctggtc accctgatcg ctgagcacct ggctgacggt 5100 gctctgcccc cccagctcct gttccactac cgtaacctgg tggctgtgct gcgcctggtc 5160 acccgtatct ccgctctgcc cggcctgaac aacggccagc tggctgagga acccctgtcc 5220 gcttacgtga acgctctgca cgaccacagg ctgtggcccc ccttcgtgac ccacctccct 5280 cgtaacatgg aaggtgtcca ggtggtggct gatcgtcagc ccctgaaccc cgctaacatc 5340 gaggctcgtc accacggtgt ctccgacgtg ccccgtctgg gtgctatgga cgctgacgag 5400 cccctgttcg tggacgacta ccgtgctacc gacgacgagt ggaccctgca aaaggtgttc 5460 tacctgtgcc tgatccccgc tatgaccaac aaccgtgctt gcggcctggg cctgaacctc 5520 aagactctgc tggtggacct gttctaccgt cccgccttcc tgctcatgcc cgctgctacc 5580 gctgtgtcca cctccggcac cacctccaag gaatccacct ctggtgtcac ccccgaggac 5640 tccgtggctg ctcagcgtca ggctgtgggc gagatgctga ccgagctggt cgaggacgtg 5700 gccaccgacg ctcacacccc tctgctgcag gcttgccgcg agctgttcct ggctgtgcag 5760 ttcgtgggcg agcacgtgaa ggtgctggaa gtgcgtgctc ccctggacca cgctcagagg 5820 cagggactgc ccgacttcat ctcccgtcag catgtgctgt acaacggttg ctgcgtcgtg 5880 accgctccta agaccctgat cgagtactcc ctgcccgtgc ccttccaccg tttctactcc 5940 aaccccacca tctgcgctgc tctgtccgac gacatcaagc gttacgtgac cgagttcccc 6000 cactaccata gacacgatgg tggtttcccc ctgcccaccg ctttcgctca cgagtaccac 6060 aactggctgc gtagcccctt ctcccgttac tccgctacct gccccaacgt gctgcactcc 6120 gtgatgaccc tggctgctat gctgtacaag atctcccccg tgtccctggt gctgcagacc 6180 aaggctcaca tccaccccgg tttcgctctg accgctgtgc gtaccgacac cttcgaggtg 6240 gacatgctgc tgtactccgg caagtcctgc acctccgtca tcatcaacaa ccccatcgtg 6300 accaaggaag agagggacat ctccaccacc taccacgtga cccagaacat caacaccgtg 6360 gacatgggcc tgggttacac ctccaacact tgcgtggcct acgtgaaccg cgtccgcacc 6420 gacatgggtg tccgtgtgca ggacctgttc cgtgtgttcc ccatgaacgt gtaccgccac 6480 gatgaggtgg accgttggat caggcacgct gctggcgtcg agcgtcccca gctgctggac 6540 accgagacta tctccatgct gaccttcggt tccatgtccg agcgcaacgc tgctgctacc 6600 gtgcacggcc agaaggctgt ctgcgagctg atcctgaccc ctgtgactat ggacgtgaac 6660 tacttcaaga tcaccaacaa ccctcgtggt cgtgcttcct gcatgctggg cgtggacccc 6720 tacgacaccg aggctgccac caaggctatc tacgaccacc gcgaggctga cgctcagacc 6780 ttcgctgcta cccacaaccc atgggcttcc caggctggtt gcctgtccga cgtcctgtac 6840 aacacccgtc accgcgagcg tctgggctac aactccaagt tctactcccc ctgcgctcag 6900 tacttcaaca ccgaggaaat catcgctgcc aacaagaccc tcttcaagac catcgacgag 6960 tacctgctgc gcgctaagga ctgcatccgt ggcgacaccg acactcagta cgtgtgcgtc 7020 gagggaaccg agcagctgat cgagaaccct tgccgtctga cccaagaggc tctgcccatc 7080 ctgtccacca ccaccctggc tctgatggaa actaagctga agggtggcgc tggtgctttc 7140 gctacctccg agactcactt cggcaactac gtcgtgggag agatcatccc cctgcagcag 7200 tccatgctgt tcaacagcta agagctcaag cttgtcgaga agtactagag gatcataatc 7260 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 7320 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 7380 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 7440 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 7500 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgt 7560 ggctagcttt gtttaacttt aagaaggaga tacatctaga ccggaatatt aatagatcat 7620 ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac 7680 agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg 7740 cgcggatccc ggtccgaagc gcgcggaatt caaaggccta cgtcgacgcc accatggaat 7800 cccgtggtcg tcgttgcccc gagatgatct ccgtgctggg tcccatctcc ggtcacgtcc 7860 tgaaggctgt gttctcccgt ggcgacaccc ccgtgctgcc ccacgaaact cgtctgctgc 7920 agaccggtat ccacgtgcgt gtgtcccagc cctccctgat cctggtgtcc cagtacaccc 7980 ccgactccac cccttgccac cgcggagaca accagctgca ggtccagcac acctacttca 8040 ccggttccga ggtcgagaac gtgtccgtga acgtgcacaa ccccaccggt cgttccatct 8100 gcccctccca agagcccatg tccatctacg tgtacgctct gcccctgaag atgctgaaca 8160 tcccctccat caacgtgcac cactacccct ccgctgctga gcgcaagcac cgtcacctcc 8220 ccgtggctga cgctgtgatc cacgcttccg gcaagcagat gtggcaggct cgtctgaccg 8280 tgtccggcct ggcttggacc cgtcagcaga accagtggaa ggaacccgac gtgtactaca 8340 cctccgcttt cgtgttcccc accaaggacg tggccctgcg tcacgtcgtg tgcgctcacg 8400 aactcgtgtg ctccatggaa aacacccgtg ctaccaagat gcaagtgatc ggcgaccagt 8460 acgtgaaggt gtacctggaa tccttctgcg aggacgtgcc ctccggcaag ctgttcatgc 8520 acgtgaccct gggttccgac gtggaagagg acctgaccat gacccgtaac ccccagccct 8580 tcatgcgtcc ccacgagcgt aacggtttca ccgtgctgtg ccccaagaac atgatcatca 8640 agcccggcaa gatctcccac atcatgctgg acgtggcctt cacctcccac gagcacttcg 8700 gcctgctgtg ccctaagtcc atccccggcc tgtccatctc cggcaacctg ctgatgaacg 8760 gccagcagat cttcctggaa gtgcaggcta tccgtgaaac cgtcgagctg cgtcagtacg 8820 accctgtggc tgctctgttc ttcttcgaca tcgacctgct gctgcagcgt ggtccccagt 8880 actccgagca ccccaccttc accagccagt accgtatcca gggcaagctg gaataccgtc 8940 acacctggga ccgtcacgac gagggtgctg ctcagggcga cgacgacgtg tggacctccg 9000 gttccgactc cgacgaggaa ctggtcacca ccgagcgcaa gaccccccgt gtgaccggtg 9060 gtggtgctat ggctggtgct tccacctccg ctggtcgcaa gcgcaagtcc gcttcctccg 9120 ctaccgcttg caccgctggt gtcatgaccc gtggtcgcct gaaggctgag tccaccgtgg 9180 ctcccgaaga ggacactgac gaggactccg acaacgagat ccacaacccc gctgtgttca 9240 cctggccccc ctggcaggct ggtatcctgg ctcgtaacct ggtgcccatg gtggctaccg 9300 tgcagggcca gaacctgaag taccaagagt tcttctggga cgccaacgac atctaccgta 9360 tcttcgctga gctggaaggc gtgtggcagc ccgctgctca gcccaagcgt cgtcgtcacc 9420 gtcaggacgc tctgcctggt ccctgtatcg cttccacccc caagaagcac cgcggctaaa 9480 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 9540 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 9600 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 9660 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 9720 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 9780 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccg 9840 gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat 9900 tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat 9960 accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcgc caccatgacc 10020 atggacgagc agcagcccca ggctgtgacc cccgtgtacg tgggcggttt cctggctcgt 10080 tacgaccagt cccccgacga ggctgagctg ctgctgccac gtgacgtggt cgaacactgg 10140 ctgcacgctc agggccaggg acagccttcc ctgtccgtgg ctctgcccct gaacatcaac 10200 cacgacgaca ccgctgtcgt gggtcacgtg gccgctatgc agtccgtgcg tgacggcctg 10260 ttctgcctgg gttgcgtgac ctccccccgt ttcctggaaa tcgtgcgtcg tgcttccgag 10320 aagtccgagc tggtgtcccg tggtcccgtg tccccactgc agcccgacaa ggtggtcgag 10380 ttcctgtccg gttcctacgc tggcctgtcc ctgtcatccc gtcgttgcga cgacgtcgag 10440 gctgctacct ccctgagcgg ctccgagact acccccttca agcacgtggc cctgtgctcc 10500 gtgggtcgta ggcgtggaac cctggctgtg tacggtcgtg accccgagtg ggtcacccag 10560 cgtttccccg acctgaccgc tgctgaccgt gacggactgc gtgctcagtg gcagcgttgc 10620 ggttccaccg ctgtggacgc ttccggcgac cccttccgtt ccgactccta cggcctgctg 10680 ggcaactccg tggacgctct gtacatccgc gagcgtctgc ccaagctgcg ttacgacaag 10740 cagctcgtgg gtgtcaccga gcgcgagtcc tacgtgaagg cttccgtgtc ccccgaggct 10800 gcttgcgaca tcaaggctgc ttccgctgag cgttctggcg acagccgctc ccaggctgct 10860 actcctgctg ctggtgctcg tgtgccctcc agctccccat ccccacctgt cgagcctccc 10920 tcccccgtgc aacctcctgc tctgcctgct tccccctccg tgctgcctgc tgagtccagc 10980 ccctccctgt caccctctga gcctgctgag gctgcctcca tgtcccaccc tctgagcgct 11040 gctgtgactg ctgctaccgc tccccctggt gctactgtgg ctggtgcttc ccccgctgtg 11100 ccttccctgg cttggcctca cgacggtgtc tacctgccca aggacgcttt cttctccctg 11160 ctgggcgctt cccgttccgc tgctcccgtg atgtaccccg gtgctgtggc tgctcccccc 11220 agcgcttcac ctgctcctct gcccctgccc tcctaccccg cttcctacgg tgctcccgtc 11280 gtgggttacg accagctggc tgctcgtcac ttcgctgact acgtggaccc ccactacccc 11340 ggctggggtc gtcgttacga gcccgctcct tccctgcacc catcctaccc tgtgccccct 11400 cctccatcac ccgcttacta ccgtcgtcgt gactcccccg gtggcatgga cgagcctcca 11460 tctggatggg agcgttacga cggttcccac cgtggccagt cccaaaagca gcaccgtcac 11520 ggtggttccg gtggtcacaa caagcgtcgc aaggaagccg ctgctgcatc ctccagctcc 11580 gacgaggacc tgagcttccc cggcgaggct gaacacggtc gtgctcgcaa gcgtctgaag 11640 tcccacgtga actccgacgg aggtagcgga ggccacgctg gttccaacca gcagcagcaa 11700 cagcgctacg acgagctgcg tgacgctatc cacgagctga agcgtgacct gttcgctgct 11760 cgccagtcct ccaccctgct gtctgctgct ctgccagctg ccgcttcttc ctcccctacc 11820 accaccaccg tgtgcacccc tactggcgag ctgacctctg gtggtggcga gactcccacc 11880 gctctgctgt ccggtggtgc taaggtggcc gagcgtgctc aggctggtgt cgtgaacgct 11940 tcctgccgtc tggctaccgc ttccggttcc gaggctgcca ccgctggtcc ctctaccgct 12000 ggttcctcat cctgcccagc ttccgtggtg ctggctgccg ctgctgctca agccgccgct 12060 gcttcacagt cccccccaaa ggatatggtg gacctgaacc gtcgtatctt cgtggctgct 12120 ctgaacaagc tcgagtaata aaagcttgtc gagaagtact agaggatcat aatcagccat 12180 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 12240 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 12300 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 12360 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 12420 cctagaagat ccggctgcta acaaagcccg aaaggaagct gggaatatta atagatcatg 12480 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 12540 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 12600 gcggatccgc caccatggct gctatggaag ctaacatctt ctgcaccttc gaccacaagc 12660 tgtctatcgc tgacgtgggc aagctgacca agctggtggc tgctgtggtg cccatccccc 12720 agcgtctgca cctgatcaag cactaccagc tgggcctgca ccagttcgtg gaccacaccc 12780 gtggttacgt gcgtctgcgt ggcctgctgc gtaacatgac cctgaccctg atgcgtcgtg 12840 tcgagggcaa ccagatcctg ctgcacgtgc ccacccacgg cctgctgtac accgtgctga 12900 acaccggtcc cgtgacctgg gagaagggcg acgctctgtg cgtgctgccc cccctgttcc 12960 acggtcccct ggctcgtgaa aacctgttga ccctgggcca gtgggagctg gtgctgccct 13020 ggatcgtgcc catgcccctg gctctggaaa tcaaccagcg cctgctgatc atgggcctgt 13080 tctccctgga ccgttcctac gaagaagtga aggctgctgt ccagcagctg cagaccatca 13140 ccttccgtga cgctaccttc accatccccg accccgtgat cgaccagcac ctcctgatcg 13200 acatgaagac cgcttgcctg tccatgtcca tggtggctaa cctggcttcc gagctgacca 13260 tgacctacgt ccgcaagctg gctttggagg actcttccat gctgctggtc aagtgccaag 13320 agctgctgat gcgtctggac cgcgagcgtt ccgtgggcga gcctcgtact cccgctcgtc 13380 ctcagcacgt gtcccccgac gacgagatcg ctcgtctgtc cgctctgttc gtgatgctgc 13440 gtcagctgga cgacctgatc cgcgagcagg tcgtgttcac cgtgtgcgac gtgagcccag 13500 acaacaagtc cgctacctgc atcttcaagg gctaaggcgc gccaagcttg tcgagaagta 13560 ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 13620 cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 13680 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 13740 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 13800 ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag 13860 ctgagttggc tgctgccacc gctgagcaat aactatcata acccctagga gatccgaacc 13920 agataagtga aatctagttc caaactattt tgtcattttt aattttcgta ttagcttacg 13980 acgctacacc cagttcccat ctattttgtc actcttccct aaataatcct taaaaactcc 14040 atttccaccc ctcccagttc ccaactattt tgtccgccca ca 14082 <210> 69 <211> 14641 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 69 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaccg gaatattaat 7200 agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt 7260 tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac 7320 catcgggcgc ggatcccggt ccgaagcgcg cggaattcaa aggcctacgt cgacgccacc 7380 atggaatccc gtggtcgtcg ttgccccgag atgatctccg tgctgggtcc catctccggt 7440 cacgtcctga aggctgtgtt ctcccgtggc gacacccccg tgctgcccca cgaaactcgt 7500 ctgctgcaga ccggtatcca cgtgcgtgtg tcccagccct ccctgatcct ggtgtcccag 7560 tacacccccg actccacccc ttgccaccgc ggagacaacc agctgcaggt ccagcacacc 7620 tacttcaccg gttccgaggt cgagaacgtg tccgtgaacg tgcacaaccc caccggtcgt 7680 tccatctgcc cctcccaaga gcccatgtcc atctacgtgt acgctctgcc cctgaagatg 7740 ctgaacatcc cctccatcaa cgtgcaccac tacccctccg ctgctgagcg caagcaccgt 7800 cacctccccg tggctgacgc tgtgatccac gcttccggca agcagatgtg gcaggctcgt 7860 ctgaccgtgt ccggcctggc ttggacccgt cagcagaacc agtggaagga acccgacgtg 7920 tactacacct ccgctttcgt gttccccacc aaggacgtgg ccctgcgtca cgtcgtgtgc 7980 gctcacgaac tcgtgtgctc catggaaaac acccgtgcta ccaagatgca agtgatcggc 8040 gaccagtacg tgaaggtgta cctggaatcc ttctgcgagg acgtgccctc cggcaagctg 8100 ttcatgcacg tgaccctggg ttccgacgtg gaagaggacc tgaccatgac ccgtaacccc 8160 cagcccttca tgcgtcccca cgagcgtaac ggtttcaccg tgctgtgccc caagaacatg 8220 atcatcaagc ccggcaagat ctcccacatc atgctggacg tggccttcac ctcccacgag 8280 cacttcggcc tgctgtgccc taagtccatc cccggcctgt ccatctccgg caacctgctg 8340 atgaacggcc agcagatctt cctggaagtg caggctatcc gtgaaaccgt cgagctgcgt 8400 cagtacgacc ctgtggctgc tctgttcttc ttcgacatcg acctgctgct gcagcgtggt 8460 ccccagtact ccgagcaccc caccttcacc agccagtacc gtatccaggg caagctggaa 8520 taccgtcaca cctgggaccg tcacgacgag ggtgctgctc agggcgacga cgacgtgtgg 8580 acctccggtt ccgactccga cgaggaactg gtcaccaccg agcgcaagac cccccgtgtg 8640 accggtggtg gtgctatggc tggtgcttcc acctccgctg gtcgcaagcg caagtccgct 8700 tcctccgcta ccgcttgcac cgctggtgtc atgacccgtg gtcgcctgaa ggctgagtcc 8760 accgtggctc ccgaagagga cactgacgag gactccgaca acgagatcca caaccccgct 8820 gtgttcacct ggcccccctg gcaggctggt atcctggctc gtaacctggt gcccatggtg 8880 gctaccgtgc agggccagaa cctgaagtac caagagttct tctgggacgc caacgacatc 8940 taccgtatct tcgctgagct ggaaggcgtg tggcagcccg ctgctcagcc caagcgtcgt 9000 cgtcaccgtc aggacgctct gcctggtccc tgtatcgctt ccacccccaa gaagcaccgc 9060 ggctaaaagc ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag 9120 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 9180 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 9240 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 9300 ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc 9360 tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactatc 9420 ataaccggaa tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa 9480 taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat 9540 tattcatacc gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcgccac 9600 catgaccatg gacgagcagc agccccaggc tgtgaccccc gtgtacgtgg gcggtttcct 9660 ggctcgttac gaccagtccc ccgacgaggc tgagctgctg ctgccacgtg acgtggtcga 9720 acactggctg cacgctcagg gccagggaca gccttccctg tccgtggctc tgcccctgaa 9780 catcaaccac gacgacaccg ctgtcgtggg tcacgtggcc gctatgcagt ccgtgcgtga 9840 cggcctgttc tgcctgggtt gcgtgacctc cccccgtttc ctggaaatcg tgcgtcgtgc 9900 ttccgagaag tccgagctgg tgtcccgtgg tcccgtgtcc ccactgcagc ccgacaaggt 9960 ggtcgagttc ctgtccggtt cctacgctgg cctgtccctg tcatcccgtc gttgcgacga 10020 cgtcgaggct gctacctccc tgagcggctc cgagactacc cccttcaagc acgtggccct 10080 gtgctccgtg ggtcgtaggc gtggaaccct ggctgtgtac ggtcgtgacc ccgagtgggt 10140 cacccagcgt ttccccgacc tgaccgctgc tgaccgtgac ggactgcgtg ctcagtggca 10200 gcgttgcggt tccaccgctg tggacgcttc cggcgacccc ttccgttccg actcctacgg 10260 cctgctgggc aactccgtgg acgctctgta catccgcgag cgtctgccca agctgcgtta 10320 cgacaagcag ctcgtgggtg tcaccgagcg cgagtcctac gtgaaggctt ccgtgtcccc 10380 cgaggctgct tgcgacatca aggctgcttc cgctgagcgt tctggcgaca gccgctccca 10440 ggctgctact cctgctgctg gtgctcgtgt gccctccagc tccccatccc cacctgtcga 10500 gcctccctcc cccgtgcaac ctcctgctct gcctgcttcc ccctccgtgc tgcctgctga 10560 gtccagcccc tccctgtcac cctctgagcc tgctgaggct gcctccatgt cccaccctct 10620 gagcgctgct gtgactgctg ctaccgctcc ccctggtgct actgtggctg gtgcttcccc 10680 cgctgtgcct tccctggctt ggcctcacga cggtgtctac ctgcccaagg acgctttctt 10740 ctccctgctg ggcgcttccc gttccgctgc tcccgtgatg taccccggtg ctgtggctgc 10800 tccccccagc gcttcacctg ctcctctgcc cctgccctcc taccccgctt cctacggtgc 10860 tcccgtcgtg ggttacgacc agctggctgc tcgtcacttc gctgactacg tggaccccca 10920 ctaccccggc tggggtcgtc gttacgagcc cgctccttcc ctgcacccat cctaccctgt 10980 gccccctcct ccatcacccg cttactaccg tcgtcgtgac tcccccggtg gcatggacga 11040 gcctccatct ggatgggagc gttacgacgg ttcccaccgt ggccagtccc aaaagcagca 11100 ccgtcacggt ggttccggtg gtcacaacaa gcgtcgcaag gaagccgctg ctgcatcctc 11160 cagctccgac gaggacctga gcttccccgg cgaggctgaa cacggtcgtg ctcgcaagcg 11220 tctgaagtcc cacgtgaact ccgacggagg tagcggaggc cacgctggtt ccaaccagca 11280 gcagcaacag cgctacgacg agctgcgtga cgctatccac gagctgaagc gtgacctgtt 11340 cgctgctcgc cagtcctcca ccctgctgtc tgctgctctg ccagctgccg cttcttcctc 11400 ccctaccacc accaccgtgt gcacccctac tggcgagctg acctctggtg gtggcgagac 11460 tcccaccgct ctgctgtccg gtggtgctaa ggtggccgag cgtgctcagg ctggtgtcgt 11520 gaacgcttcc tgccgtctgg ctaccgcttc cggttccgag gctgccaccg ctggtccctc 11580 taccgctggt tcctcatcct gcccagcttc cgtggtgctg gctgccgctg ctgctcaagc 11640 cgccgctgct tcacagtccc ccccaaagga tatggtggac ctgaaccgtc gtatcttcgt 11700 ggctgctctg aacaagctcg agtaataaaa gcttgtcgag aagtactaga ggatcataat 11760 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 11820 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 11880 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 11940 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 12000 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctggg aatattaata 12060 gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt 12120 cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc 12180 atcgggcgcg gatccgccac catggctgct atggaagcta acatcttctg caccttcgac 12240 cacaagctgt ctatcgctga cgtgggcaag ctgaccaagc tggtggctgc tgtggtgccc 12300 atcccccagc gtctgcacct gatcaagcac taccagctgg gcctgcacca gttcgtggac 12360 cacacccgtg gttacgtgcg tctgcgtggc ctgctgcgta acatgaccct gaccctgatg 12420 cgtcgtgtcg agggcaacca gatcctgctg cacgtgccca cccacggcct gctgtacacc 12480 gtgctgaaca ccggtcccgt gacctgggag aagggcgacg ctctgtgcgt gctgcccccc 12540 ctgttccacg gtcccctggc tcgtgaaaac ctgttgaccc tgggccagtg ggagctggtg 12600 ctgccctgga tcgtgcccat gcccctggct ctggaaatca accagcgcct gctgatcatg 12660 ggcctgttct ccctggaccg ttcctacgaa gaagtgaagg ctgctgtcca gcagctgcag 12720 accatcacct tccgtgacgc taccttcacc atccccgacc ccgtgatcga ccagcacctc 12780 ctgatcgaca tgaagaccgc ttgcctgtcc atgtccatgg tggctaacct ggcttccgag 12840 ctgaccatga cctacgtccg caagctggct ttggaggact cttccatgct gctggtcaag 12900 tgccaagagc tgctgatgcg tctggaccgc gagcgttccg tgggcgagcc tcgtactccc 12960 gctcgtcctc agcacgtgtc ccccgacgac gagatcgctc gtctgtccgc tctgttcgtg 13020 atgctgcgtc agctggacga cctgatccgc gagcaggtcg tgttcaccgt gtgcgacgtg 13080 agcccagaca acaagtccgc tacctgcatc ttcaagggct aaggcgcgcc aagcttgtcg 13140 agaagtacta gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa 13200 aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta 13260 acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa 13320 ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt 13380 atcatgtctg gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga 13440 aaggaagctg agttggctgc tgctgagtag tgcgcgagca aaatttaagc tacaacaagg 13500 cacgcgtccg gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat 13560 aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg 13620 gattattcat accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcaa 13680 aggcctacat ggagtggaac acactagtac taggtctttt ggttttatcg gtagcggcaa 13740 gttccaacca tacgtcgact gctagcacac cgagtccctc tagctctact cacacctcaa 13800 cgaccgtgaa ggcaacgact actgcgacaa ctagtacaac tacggtgaca agtacgactt 13860 catcaacgac tagtaccaaa cccggttcca ccactcacga ccccaatgtg atgagaccac 13920 atgctcacaa tgatttttac aaggcgcatt gtacatcgca tatgtatgaa ctttctctgt 13980 ccagctttgc ggcctggtgg actatgctta atgctctcat tctcatggga gctttttgta 14040 tcgtactacg acattgctgt ttccagaact ttactgcaac caccaccaaa ggctattgat 14100 aaaagcttgt cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt 14160 tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa 14220 ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca 14280 caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca 14340 tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga tccggctgct 14400 aacaaagccc gaaaggaagc tgagttggct gctgccaccg ctgagcaata actatcataa 14460 cccctaggag atccgaacca gataagtgaa atctagttcc aaactatttt gtcattttta 14520 attttcgtat tagcttacga cgctacaccc agttcccatc tattttgtca ctcttcccta 14580 aataatcctt aaaaactcca tttccacccc tcccagttcc caactatttt gtccgcccac 14640 a 14641 <210> 70 <211> 14787 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 70 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttaggcgtcc tcgaagtcct cgtcgtcgtc gtcgtcctcc 2400 tcctcgcgca ggcggcggga ctccagggag tcgtggtggg acagggcggc cacctcctcg 2460 ccggaggcgg tggccagggc ctggtacttc acggagccgg agccgcggcc gcggaagtag 2520 cgcacggcgc ggcaggtggt gaacatggcc cagatgaaga acagcatgcc gaaggaccag 2580 gagatgccgg tgcggtactc gttggacagg aaggtgtcgt actgcacgat ggggtagatc 2640 aggccgcaca ggccgaagaa ggcgcccagg tggtagccga actgcacctt cacgtactgg 2700 aagaacacgg cctcgatcag caggaagtag atgatggaga tgatggcgta caccacgaac 2760 acggccagca ccatgtggcc ggtgcgcacg aagaagttgt tgccgaagcc gtagcacagg 2820 gccatggcca ccacggtggt gttgaagccc agggccacct ccaccaggtt cacgatcagg 2880 gtgcggaact gcacggtgcc cttcagcttg gggtgcaggc gggagaagaa gaacagggag 2940 cgcttgtagg agcggtactg ggtcaccatg gacacgttga agatggtcag gcagaagaag 3000 tgcacggcgg ccatgaaggc gatcatggag ggcaggcgga aggacatggt cagggtgaac 3060 agctggaagg tgtccatgga caggatgaac aggaaggcgg tcagggagtc gcccatgtag 3120 gagatgtcgc gggtggactg gttcagggac atgcccttgt ccttgcgcat ggagatcttg 3180 atccagcaca ccaggtagta gatggtcacg gccaggaaca ccagctgcat gaacacggcg 3240 tagcacacca gctgcacgga gtccaggaac agcatggggg tgtgcaggtg catcacgttg 3300 taggcggaca tgttcaggcg ctcgaagtcc accacgtggt agtacacgca ggggtagccc 3360 aggtggggga agttggacag caccaggtgc acggacacgt tcacgaaggt cagcaccatg 3420 aacacgatgg aggcggacca ggtgcgggtg ttcaccttgt ccacgtggga gggggccatg 3480 gtggcctcga gatcccgggt gatcaagtct tcgtcgagtg attgtaaata aaatgtaatt 3540 tacagtatag tattttaatt aatatacaaa tgatttgata ataattctta tttaactata 3600 atatattgtg ttgggttgaa ttaaaggtcc gtatactagt atcgattcgc gacctactcc 3660 ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta 3720 ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca 3780 taccgtccca ccatcgggcg cggatccgcc accatggaaa actggtccgc tctggaactg 3840 ctgcccaagg tcggaatccc taccgacttc ctgacccacg tcaagacctc cgctggcgag 3900 gaaatgttcg aggctctgag gatctactac ggcgacgacc ccgagcgtta caacatccac 3960 ttcgaggcta tcttcggcac cttctgcaac cgtctggaat gggtgtactt cctgacttcc 4020 ggcctggctg ctgctgctca cgctatcaag ttccacgacc tgaacaagct gaccaccggc 4080 aagatgctgt tccacgtgca agtgccccgt gtggcttccg gtgctggcct gcctacctcc 4140 cgtcagacca ccatcatggt caccaagtac tccgagaagt cccccatcac catccctttc 4200 gagctgtccg ctgcttgcct gacttacctg cgtgaaacct tcgagggcac catcctggac 4260 aagatcctga acgtcgaggc tatgcacacc gtgctgcgtg ctctgaagaa caccgctgac 4320 gctatggaac gtggcctgat ccacagcttc ctccagaccc tgctgaggaa ggctcccccc 4380 tacttcgtgg tgcagaccct ggtcgagaac gctaccctgg ctcgtcaggc tctgaaccgt 4440 atccagcgct ccaacatcct gcagtccttc aaggctaaga tgctggctac cctgttcctg 4500 ctgaaccgta cccgtgaccg tgactacgtg ctgaagttcc tgacccgtct ggctgaggct 4560 gctaccgact ccatcctcga caaccctact acctacacca cctcctccgg tgctaagatc 4620 tccggtgtca tggtgtccac cgctaacgtg atgcagatca tcatgtccct gctgtcctcc 4680 cacatcacta aggaaaccgt gtccgctccc gctacctacg gcaacttcgt gctgtccccc 4740 gagaacgctg tgaccgctat ctcctaccac tctatcctgg ctgacttcaa ctcctacaag 4800 gctcacctga cctccggcca gccccacctc cccaacgact ccctgagcca ggctggtgct 4860 cactccctga cccccctgtc catggacgtg atccgtctgg gcgaaaagac cgtgatcatg 4920 gaaaacctgc gtcgcgtgta caagaacacc gacaccaagg accccctgga acgtaacgtg 4980 gacctgacct tcttcttccc cgtgggcctg tacctgcccg aggaccgtgg ttacaccacc 5040 gtcgagtcca aggtcaagct gaacgacacc gtgcgtaacg ctctgcccac caccgcttac 5100 ctgctgaaca gggaccgtgc tgtgcaaaag atcgacttcg tggacgctct caagaccctg 5160 tgccaccccg tgctgcacga gcctgctcca tgcctgcagg ctttcaccga gcgtggtccc 5220 ccatccgagc ccgctatgca gcgtctgctg gaatgccgtt tccagcaaga gcccatgggt 5280 ggtgctgctc gtcgtatccc ccacttctac cgtgtgcgcc gcgaggtgcc ccgtaccgtg 5340 aacgagatga agcaggactt cgtggtcacc gacttctaca aggttggaaa catcaccctg 5400 tacaccgagc tgcacccttt cttcgacttc acccactgcc aagagaactc cgagactgtg 5460 gctctgtgca ccccccgtat cgtgatcggc aacctgcccg acggcctggc tcccggtccc 5520 ttccacgagc tgaggacctg ggagatcatg gaacacatgc gcctgcgtcc cccacccgac 5580 tacgaggaaa ccctgcgtct gttcaagacc accgtgacct cccccaacta ccccgagctg 5640 tgctacctgg tggacgtgct ggtgcacggc aacgctgacg ctttcctgct gatccgcgct 5700 ttcatcgctc gttgcatcgt gaacatgttc cacacccgtc agctgctggt gttcgctcac 5760 tcctacgctc tggtcaccct gatcgctgag cacctggctg acggtgctct gcccccccag 5820 ctcctgttcc actaccgtaa cctggtggct gtgctgcgcc tggtcacccg tatctccgct 5880 ctgcccggcc tgaacaacgg ccagctggct gaggaacccc tgtccgctta cgtgaacgct 5940 ctgcacgacc acaggctgtg gccccccttc gtgacccacc tccctcgtaa catggaaggt 6000 gtccaggtgg tggctgatcg tcagcccctg aaccccgcta acatcgaggc tcgtcaccac 6060 ggtgtctccg acgtgccccg tctgggtgct atggacgctg acgagcccct gttcgtggac 6120 gactaccgtg ctaccgacga cgagtggacc ctgcaaaagg tgttctacct gtgcctgatc 6180 cccgctatga ccaacaaccg tgcttgcggc ctgggcctga acctcaagac tctgctggtg 6240 gacctgttct accgtcccgc cttcctgctc atgcccgctg ctaccgctgt gtccacctcc 6300 ggcaccacct ccaaggaatc cacctctggt gtcacccccg aggactccgt ggctgctcag 6360 cgtcaggctg tgggcgagat gctgaccgag ctggtcgagg acgtggccac cgacgctcac 6420 acccctctgc tgcaggcttg ccgcgagctg ttcctggctg tgcagttcgt gggcgagcac 6480 gtgaaggtgc tggaagtgcg tgctcccctg gaccacgctc agaggcaggg actgcccgac 6540 ttcatctccc gtcagcatgt gctgtacaac ggttgctgcg tcgtgaccgc tcctaagacc 6600 ctgatcgagt actccctgcc cgtgcccttc caccgtttct actccaaccc caccatctgc 6660 gctgctctgt ccgacgacat caagcgttac gtgaccgagt tcccccacta ccatagacac 6720 gatggtggtt tccccctgcc caccgctttc gctcacgagt accacaactg gctgcgtagc 6780 cccttctccc gttactccgc tacctgcccc aacgtgctgc actccgtgat gaccctggct 6840 gctatgctgt acaagatctc ccccgtgtcc ctggtgctgc agaccaaggc tcacatccac 6900 cccggtttcg ctctgaccgc tgtgcgtacc gacaccttcg aggtggacat gctgctgtac 6960 tccggcaagt cctgcacctc cgtcatcatc aacaacccca tcgtgaccaa ggaagagagg 7020 gacatctcca ccacctacca cgtgacccag aacatcaaca ccgtggacat gggcctgggt 7080 tacacctcca acacttgcgt ggcctacgtg aaccgcgtcc gcaccgacat gggtgtccgt 7140 gtgcaggacc tgttccgtgt gttccccatg aacgtgtacc gccacgatga ggtggaccgt 7200 tggatcaggc acgctgctgg cgtcgagcgt ccccagctgc tggacaccga gactatctcc 7260 atgctgacct tcggttccat gtccgagcgc aacgctgctg ctaccgtgca cggccagaag 7320 gctgtctgcg agctgatcct gacccctgtg actatggacg tgaactactt caagatcacc 7380 aacaaccctc gtggtcgtgc ttcctgcatg ctgggcgtgg acccctacga caccgaggct 7440 gccaccaagg ctatctacga ccaccgcgag gctgacgctc agaccttcgc tgctacccac 7500 aacccatggg cttcccaggc tggttgcctg tccgacgtcc tgtacaacac ccgtcaccgc 7560 gagcgtctgg gctacaactc caagttctac tccccctgcg ctcagtactt caacaccgag 7620 gaaatcatcg ctgccaacaa gaccctcttc aagaccatcg acgagtacct gctgcgcgct 7680 aaggactgca tccgtggcga caccgacact cagtacgtgt gcgtcgaggg aaccgagcag 7740 ctgatcgaga acccttgccg tctgacccaa gaggctctgc ccatcctgtc caccaccacc 7800 ctggctctga tggaaactaa gctgaagggt ggcgctggtg ctttcgctac ctccgagact 7860 cacttcggca actacgtcgt gggagagatc atccccctgc agcagtccat gctgttcaac 7920 agctaagagc tcaagcttgt cgagaagtac tagaggatca taatcagcca taccacattt 7980 gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa 8040 atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc 8100 aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 8160 tccaaactca tcaatgtatc ttatcatgtc tggatctgat cactgcttga gcctagaaga 8220 tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgtggcta gctttgttta 8280 actttaagaa ggagatacat ctagaccgga atattaatag atcatggaga taattaaaat 8340 gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt tgtaataaaa 8400 aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg atcccggtcc 8460 gaagcgcgcg gaattcaaag gcctacgtcg acgccaccat ggaatcccgt ggtcgtcgtt 8520 gccccgagat gatctccgtg ctgggtccca tctccggtca cgtcctgaag gctgtgttct 8580 cccgtggcga cacccccgtg ctgccccacg aaactcgtct gctgcagacc ggtatccacg 8640 tgcgtgtgtc ccagccctcc ctgatcctgg tgtcccagta cacccccgac tccacccctt 8700 gccaccgcgg agacaaccag ctgcaggtcc agcacaccta cttcaccggt tccgaggtcg 8760 agaacgtgtc cgtgaacgtg cacaacccca ccggtcgttc catctgcccc tcccaagagc 8820 ccatgtccat ctacgtgtac gctctgcccc tgaagatgct gaacatcccc tccatcaacg 8880 tgcaccacta cccctccgct gctgagcgca agcaccgtca cctccccgtg gctgacgctg 8940 tgatccacgc ttccggcaag cagatgtggc aggctcgtct gaccgtgtcc ggcctggctt 9000 ggacccgtca gcagaaccag tggaaggaac ccgacgtgta ctacacctcc gctttcgtgt 9060 tccccaccaa ggacgtggcc ctgcgtcacg tcgtgtgcgc tcacgaactc gtgtgctcca 9120 tggaaaacac ccgtgctacc aagatgcaag tgatcggcga ccagtacgtg aaggtgtacc 9180 tggaatcctt ctgcgaggac gtgccctccg gcaagctgtt catgcacgtg accctgggtt 9240 ccgacgtgga agaggacctg accatgaccc gtaaccccca gcccttcatg cgtccccacg 9300 agcgtaacgg tttcaccgtg ctgtgcccca agaacatgat catcaagccc ggcaagatct 9360 cccacatcat gctggacgtg gccttcacct cccacgagca cttcggcctg ctgtgcccta 9420 agtccatccc cggcctgtcc atctccggca acctgctgat gaacggccag cagatcttcc 9480 tggaagtgca ggctatccgt gaaaccgtcg agctgcgtca gtacgaccct gtggctgctc 9540 tgttcttctt cgacatcgac ctgctgctgc agcgtggtcc ccagtactcc gagcacccca 9600 ccttcaccag ccagtaccgt atccagggca agctggaata ccgtcacacc tgggaccgtc 9660 acgacgaggg tgctgctcag ggcgacgacg acgtgtggac ctccggttcc gactccgacg 9720 aggaactggt caccaccgag cgcaagaccc cccgtgtgac cggtggtggt gctatggctg 9780 gtgcttccac ctccgctggt cgcaagcgca agtccgcttc ctccgctacc gcttgcaccg 9840 ctggtgtcat gacccgtggt cgcctgaagg ctgagtccac cgtggctccc gaagaggaca 9900 ctgacgagga ctccgacaac gagatccaca accccgctgt gttcacctgg cccccctggc 9960 aggctggtat cctggctcgt aacctggtgc ccatggtggc taccgtgcag ggccagaacc 10020 tgaagtacca agagttcttc tgggacgcca acgacatcta ccgtatcttc gctgagctgg 10080 aaggcgtgtg gcagcccgct gctcagccca agcgtcgtcg tcaccgtcag gacgctctgc 10140 ctggtccctg tatcgcttcc acccccaaga agcaccgcgg ctaaaagctt gtcgagaagt 10200 actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc 10260 tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt 10320 ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag 10380 catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg 10440 tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa 10500 gctgagttgg ctgctgccac cgctgagcaa taactatcat aaccggaata ttaatagatc 10560 atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta 10620 acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg 10680 ggcgcggatc ccggtccgaa gcgcgcggaa ttcgccacca tgaccatgga cgagcagcag 10740 ccccaggctg tgacccccgt gtacgtgggc ggtttcctgg ctcgttacga ccagtccccc 10800 gacgaggctg agctgctgct gccacgtgac gtggtcgaac actggctgca cgctcagggc 10860 cagggacagc cttccctgtc cgtggctctg cccctgaaca tcaaccacga cgacaccgct 10920 gtcgtgggtc acgtggccgc tatgcagtcc gtgcgtgacg gcctgttctg cctgggttgc 10980 gtgacctccc cccgtttcct ggaaatcgtg cgtcgtgctt ccgagaagtc cgagctggtg 11040 tcccgtggtc ccgtgtcccc actgcagccc gacaaggtgg tcgagttcct gtccggttcc 11100 tacgctggcc tgtccctgtc atcccgtcgt tgcgacgacg tcgaggctgc tacctccctg 11160 agcggctccg agactacccc cttcaagcac gtggccctgt gctccgtggg tcgtaggcgt 11220 ggaaccctgg ctgtgtacgg tcgtgacccc gagtgggtca cccagcgttt ccccgacctg 11280 accgctgctg accgtgacgg actgcgtgct cagtggcagc gttgcggttc caccgctgtg 11340 gacgcttccg gcgacccctt ccgttccgac tcctacggcc tgctgggcaa ctccgtggac 11400 gctctgtaca tccgcgagcg tctgcccaag ctgcgttacg acaagcagct cgtgggtgtc 11460 accgagcgcg agtcctacgt gaaggcttcc gtgtcccccg aggctgcttg cgacatcaag 11520 gctgcttccg ctgagcgttc tggcgacagc cgctcccagg ctgctactcc tgctgctggt 11580 gctcgtgtgc cctccagctc cccatcccca cctgtcgagc ctccctcccc cgtgcaacct 11640 cctgctctgc ctgcttcccc ctccgtgctg cctgctgagt ccagcccctc cctgtcaccc 11700 tctgagcctg ctgaggctgc ctccatgtcc caccctctga gcgctgctgt gactgctgct 11760 accgctcccc ctggtgctac tgtggctggt gcttcccccg ctgtgccttc cctggcttgg 11820 cctcacgacg gtgtctacct gcccaaggac gctttcttct ccctgctggg cgcttcccgt 11880 tccgctgctc ccgtgatgta ccccggtgct gtggctgctc cccccagcgc ttcacctgct 11940 cctctgcccc tgccctccta ccccgcttcc tacggtgctc ccgtcgtggg ttacgaccag 12000 ctggctgctc gtcacttcgc tgactacgtg gacccccact accccggctg gggtcgtcgt 12060 tacgagcccg ctccttccct gcacccatcc taccctgtgc cccctcctcc atcacccgct 12120 tactaccgtc gtcgtgactc ccccggtggc atggacgagc ctccatctgg atgggagcgt 12180 tacgacggtt cccaccgtgg ccagtcccaa aagcagcacc gtcacggtgg ttccggtggt 12240 cacaacaagc gtcgcaagga agccgctgct gcatcctcca gctccgacga ggacctgagc 12300 ttccccggcg aggctgaaca cggtcgtgct cgcaagcgtc tgaagtccca cgtgaactcc 12360 gacggaggta gcggaggcca cgctggttcc aaccagcagc agcaacagcg ctacgacgag 12420 ctgcgtgacg ctatccacga gctgaagcgt gacctgttcg ctgctcgcca gtcctccacc 12480 ctgctgtctg ctgctctgcc agctgccgct tcttcctccc ctaccaccac caccgtgtgc 12540 acccctactg gcgagctgac ctctggtggt ggcgagactc ccaccgctct gctgtccggt 12600 ggtgctaagg tggccgagcg tgctcaggct ggtgtcgtga acgcttcctg ccgtctggct 12660 accgcttccg gttccgaggc tgccaccgct ggtccctcta ccgctggttc ctcatcctgc 12720 ccagcttccg tggtgctggc tgccgctgct gctcaagccg ccgctgcttc acagtccccc 12780 ccaaaggata tggtggacct gaaccgtcgt atcttcgtgg ctgctctgaa caagctcgag 12840 taataaaagc ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag 12900 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 12960 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 13020 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 13080 ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc 13140 tgctaacaaa gcccgaaagg aagctgggaa tattaataga tcatggagat aattaaaatg 13200 ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa 13260 aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccacca 13320 tggctgctat ggaagctaac atcttctgca ccttcgacca caagctgtct atcgctgacg 13380 tgggcaagct gaccaagctg gtggctgctg tggtgcccat cccccagcgt ctgcacctga 13440 tcaagcacta ccagctgggc ctgcaccagt tcgtggacca cacccgtggt tacgtgcgtc 13500 tgcgtggcct gctgcgtaac atgaccctga ccctgatgcg tcgtgtcgag ggcaaccaga 13560 tcctgctgca cgtgcccacc cacggcctgc tgtacaccgt gctgaacacc ggtcccgtga 13620 cctgggagaa gggcgacgct ctgtgcgtgc tgccccccct gttccacggt cccctggctc 13680 gtgaaaacct gttgaccctg ggccagtggg agctggtgct gccctggatc gtgcccatgc 13740 ccctggctct ggaaatcaac cagcgcctgc tgatcatggg cctgttctcc ctggaccgtt 13800 cctacgaaga agtgaaggct gctgtccagc agctgcagac catcaccttc cgtgacgcta 13860 ccttcaccat ccccgacccc gtgatcgacc agcacctcct gatcgacatg aagaccgctt 13920 gcctgtccat gtccatggtg gctaacctgg cttccgagct gaccatgacc tacgtccgca 13980 agctggcttt ggaggactct tccatgctgc tggtcaagtg ccaagagctg ctgatgcgtc 14040 tggaccgcga gcgttccgtg ggcgagcctc gtactcccgc tcgtcctcag cacgtgtccc 14100 ccgacgacga gatcgctcgt ctgtccgctc tgttcgtgat gctgcgtcag ctggacgacc 14160 tgatccgcga gcaggtcgtg ttcaccgtgt gcgacgtgag cccagacaac aagtccgcta 14220 cctgcatctt caagggctaa ggcgcgccaa gcttgtcgag aagtactaga ggatcataat 14280 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 14340 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 14400 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 14460 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 14520 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 14580 ccaccgctga gcaataacta tcataacccc taggagatcc gaaccagata agtgaaatct 14640 agttccaaac tattttgtca tttttaattt tcgtattagc ttacgacgct acacccagtt 14700 cccatctatt ttgtcactct tccctaaata atccttaaaa actccatttc cacccctccc 14760 agttcccaac tattttgtcc gcccaca 14787 <210> 71 <211> 15346 <212> DNA <213> Synthetic construct <400> 71 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaccg gaatattaat 7200 agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt 7260 tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac 7320 catcgggcgc ggatcccggt ccgaagcgcg cggaattcaa aggcctacgt cgacgccacc 7380 atggaatccc gtggtcgtcg ttgccccgag atgatctccg tgctgggtcc catctccggt 7440 cacgtcctga aggctgtgtt ctcccgtggc gacacccccg tgctgcccca cgaaactcgt 7500 ctgctgcaga ccggtatcca cgtgcgtgtg tcccagccct ccctgatcct ggtgtcccag 7560 tacacccccg actccacccc ttgccaccgc ggagacaacc agctgcaggt ccagcacacc 7620 tacttcaccg gttccgaggt cgagaacgtg tccgtgaacg tgcacaaccc caccggtcgt 7680 tccatctgcc cctcccaaga gcccatgtcc atctacgtgt acgctctgcc cctgaagatg 7740 ctgaacatcc cctccatcaa cgtgcaccac tacccctccg ctgctgagcg caagcaccgt 7800 cacctccccg tggctgacgc tgtgatccac gcttccggca agcagatgtg gcaggctcgt 7860 ctgaccgtgt ccggcctggc ttggacccgt cagcagaacc agtggaagga acccgacgtg 7920 tactacacct ccgctttcgt gttccccacc aaggacgtgg ccctgcgtca cgtcgtgtgc 7980 gctcacgaac tcgtgtgctc catggaaaac acccgtgcta ccaagatgca agtgatcggc 8040 gaccagtacg tgaaggtgta cctggaatcc ttctgcgagg acgtgccctc cggcaagctg 8100 ttcatgcacg tgaccctggg ttccgacgtg gaagaggacc tgaccatgac ccgtaacccc 8160 cagcccttca tgcgtcccca cgagcgtaac ggtttcaccg tgctgtgccc caagaacatg 8220 atcatcaagc ccggcaagat ctcccacatc atgctggacg tggccttcac ctcccacgag 8280 cacttcggcc tgctgtgccc taagtccatc cccggcctgt ccatctccgg caacctgctg 8340 atgaacggcc agcagatctt cctggaagtg caggctatcc gtgaaaccgt cgagctgcgt 8400 cagtacgacc ctgtggctgc tctgttcttc ttcgacatcg acctgctgct gcagcgtggt 8460 ccccagtact ccgagcaccc caccttcacc agccagtacc gtatccaggg caagctggaa 8520 taccgtcaca cctgggaccg tcacgacgag ggtgctgctc agggcgacga cgacgtgtgg 8580 acctccggtt ccgactccga cgaggaactg gtcaccaccg agcgcaagac cccccgtgtg 8640 accggtggtg gtgctatggc tggtgcttcc acctccgctg gtcgcaagcg caagtccgct 8700 tcctccgcta ccgcttgcac cgctggtgtc atgacccgtg gtcgcctgaa ggctgagtcc 8760 accgtggctc ccgaagagga cactgacgag gactccgaca acgagatcca caaccccgct 8820 gtgttcacct ggcccccctg gcaggctggt atcctggctc gtaacctggt gcccatggtg 8880 gctaccgtgc agggccagaa cctgaagtac caagagttct tctgggacgc caacgacatc 8940 taccgtatct tcgctgagct ggaaggcgtg tggcagcccg ctgctcagcc caagcgtcgt 9000 cgtcaccgtc aggacgctct gcctggtccc tgtatcgctt ccacccccaa gaagcaccgc 9060 ggctaaaagc ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag 9120 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 9180 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 9240 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 9300 ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc 9360 tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactatc 9420 ataaccggaa tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa 9480 taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat 9540 tattcatacc gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcgccac 9600 catgaccatg gacgagcagc agccccaggc tgtgaccccc gtgtacgtgg gcggtttcct 9660 ggctcgttac gaccagtccc ccgacgaggc tgagctgctg ctgccacgtg acgtggtcga 9720 acactggctg cacgctcagg gccagggaca gccttccctg tccgtggctc tgcccctgaa 9780 catcaaccac gacgacaccg ctgtcgtggg tcacgtggcc gctatgcagt ccgtgcgtga 9840 cggcctgttc tgcctgggtt gcgtgacctc cccccgtttc ctggaaatcg tgcgtcgtgc 9900 ttccgagaag tccgagctgg tgtcccgtgg tcccgtgtcc ccactgcagc ccgacaaggt 9960 ggtcgagttc ctgtccggtt cctacgctgg cctgtccctg tcatcccgtc gttgcgacga 10020 cgtcgaggct gctacctccc tgagcggctc cgagactacc cccttcaagc acgtggccct 10080 gtgctccgtg ggtcgtaggc gtggaaccct ggctgtgtac ggtcgtgacc ccgagtgggt 10140 cacccagcgt ttccccgacc tgaccgctgc tgaccgtgac ggactgcgtg ctcagtggca 10200 gcgttgcggt tccaccgctg tggacgcttc cggcgacccc ttccgttccg actcctacgg 10260 cctgctgggc aactccgtgg acgctctgta catccgcgag cgtctgccca agctgcgtta 10320 cgacaagcag ctcgtgggtg tcaccgagcg cgagtcctac gtgaaggctt ccgtgtcccc 10380 cgaggctgct tgcgacatca aggctgcttc cgctgagcgt tctggcgaca gccgctccca 10440 ggctgctact cctgctgctg gtgctcgtgt gccctccagc tccccatccc cacctgtcga 10500 gcctccctcc cccgtgcaac ctcctgctct gcctgcttcc ccctccgtgc tgcctgctga 10560 gtccagcccc tccctgtcac cctctgagcc tgctgaggct gcctccatgt cccaccctct 10620 gagcgctgct gtgactgctg ctaccgctcc ccctggtgct actgtggctg gtgcttcccc 10680 cgctgtgcct tccctggctt ggcctcacga cggtgtctac ctgcccaagg acgctttctt 10740 ctccctgctg ggcgcttccc gttccgctgc tcccgtgatg taccccggtg ctgtggctgc 10800 tccccccagc gcttcacctg ctcctctgcc cctgccctcc taccccgctt cctacggtgc 10860 tcccgtcgtg ggttacgacc agctggctgc tcgtcacttc gctgactacg tggaccccca 10920 ctaccccggc tggggtcgtc gttacgagcc cgctccttcc ctgcacccat cctaccctgt 10980 gccccctcct ccatcacccg cttactaccg tcgtcgtgac tcccccggtg gcatggacga 11040 gcctccatct ggatgggagc gttacgacgg ttcccaccgt ggccagtccc aaaagcagca 11100 ccgtcacggt ggttccggtg gtcacaacaa gcgtcgcaag gaagccgctg ctgcatcctc 11160 cagctccgac gaggacctga gcttccccgg cgaggctgaa cacggtcgtg ctcgcaagcg 11220 tctgaagtcc cacgtgaact ccgacggagg tagcggaggc cacgctggtt ccaaccagca 11280 gcagcaacag cgctacgacg agctgcgtga cgctatccac gagctgaagc gtgacctgtt 11340 cgctgctcgc cagtcctcca ccctgctgtc tgctgctctg ccagctgccg cttcttcctc 11400 ccctaccacc accaccgtgt gcacccctac tggcgagctg acctctggtg gtggcgagac 11460 tcccaccgct ctgctgtccg gtggtgctaa ggtggccgag cgtgctcagg ctggtgtcgt 11520 gaacgcttcc tgccgtctgg ctaccgcttc cggttccgag gctgccaccg ctggtccctc 11580 taccgctggt tcctcatcct gcccagcttc cgtggtgctg gctgccgctg ctgctcaagc 11640 cgccgctgct tcacagtccc ccccaaagga tatggtggac ctgaaccgtc gtatcttcgt 11700 ggctgctctg aacaagctcg agtaataaaa gcttgtcgag aagtactaga ggatcataat 11760 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 11820 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 11880 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 11940 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 12000 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctggg aatattaata 12060 gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt 12120 cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc 12180 atcgggcgcg gatccgccac catggctgct atggaagcta acatcttctg caccttcgac 12240 cacaagctgt ctatcgctga cgtgggcaag ctgaccaagc tggtggctgc tgtggtgccc 12300 atcccccagc gtctgcacct gatcaagcac taccagctgg gcctgcacca gttcgtggac 12360 cacacccgtg gttacgtgcg tctgcgtggc ctgctgcgta acatgaccct gaccctgatg 12420 cgtcgtgtcg agggcaacca gatcctgctg cacgtgccca cccacggcct gctgtacacc 12480 gtgctgaaca ccggtcccgt gacctgggag aagggcgacg ctctgtgcgt gctgcccccc 12540 ctgttccacg gtcccctggc tcgtgaaaac ctgttgaccc tgggccagtg ggagctggtg 12600 ctgccctgga tcgtgcccat gcccctggct ctggaaatca accagcgcct gctgatcatg 12660 ggcctgttct ccctggaccg ttcctacgaa gaagtgaagg ctgctgtcca gcagctgcag 12720 accatcacct tccgtgacgc taccttcacc atccccgacc ccgtgatcga ccagcacctc 12780 ctgatcgaca tgaagaccgc ttgcctgtcc atgtccatgg tggctaacct ggcttccgag 12840 ctgaccatga cctacgtccg caagctggct ttggaggact cttccatgct gctggtcaag 12900 tgccaagagc tgctgatgcg tctggaccgc gagcgttccg tgggcgagcc tcgtactccc 12960 gctcgtcctc agcacgtgtc ccccgacgac gagatcgctc gtctgtccgc tctgttcgtg 13020 atgctgcgtc agctggacga cctgatccgc gagcaggtcg tgttcaccgt gtgcgacgtg 13080 agcccagaca acaagtccgc tacctgcatc ttcaagggct aaggcgcgcc aagcttgtcg 13140 agaagtacta gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa 13200 aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta 13260 acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa 13320 ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt 13380 atcatgtctg gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga 13440 aaggaagctg agttggctgc tgctgagtag tgcgcgagca aaatttaagc tacaacaagg 13500 cacgcgtccg gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat 13560 aaataagtat tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg 13620 gattattcat accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcaa 13680 aggcctacat ggccccctcc cacgtggaca aggtgaacac ccgcacctgg tccgcctcca 13740 tcgtgttcat ggtgctgacc ttcgtgaacg tgtccgtgca cctggtgctg tccaacttcc 13800 cccacctggg ctacccctgc gtgtactacc acgtggtgga cttcgagcgc ctgaacatgt 13860 ccgcctacaa cgtgatgcac ctgcacaccc ccatgctgtt cctggactcc gtgcagctgg 13920 tgtgctacgc cgtgttcatg cagctggtgt tcctggccgt gaccatctac tacctggtgt 13980 gctggatcaa gatctccatg cgcaaggaca agggcatgtc cctgaaccag tccacccgcg 14040 acatctccta catgggcgac tccctgaccg ccttcctgtt catcctgtcc atggacacct 14100 tccagctgtt caccctgacc atgtccttcc gcctgccctc catgatcgcc ttcatggccg 14160 ccgtgcactt cttctgcctg accatcttca acgtgtccat ggtgacccag taccgctcct 14220 acaagcgctc cctgttcttc ttctcccgcc tgcaccccaa gctgaagggc accgtgcagt 14280 tccgcaccct gatcgtgaac ctggtggagg tggccctggg cttcaacacc accgtggtgg 14340 ccatggccct gtgctacggc ttcggcaaca acttcttcgt gcgcaccggc cacatggtgc 14400 tggccgtgtt cgtggtgtac gccatcatct ccatcatcta cttcctgctg atcgaggccg 14460 tgttcttcca gtacgtgaag gtgcagttcg gctaccacct gggcgccttc ttcggcctgt 14520 gcggcctgat ctaccccatc gtgcagtacg acaccttcct gtccaacgag taccgcaccg 14580 gcatctcctg gtccttcggc atgctgttct tcatctgggc catgttcacc acctgccgcg 14640 ccgtgcgcta cttccgcggc cgcggctccg gctccgtgaa gtaccaggcc ctggccaccg 14700 cctccggcga ggaggtggcc gccctgtccc accacgactc cctggagtcc cgccgcctgc 14760 gcgaggagga ggacgacgac gacgacgagg acttcgagga cgcctaaaag cttgtcgaga 14820 agtactagag gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa 14880 acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact 14940 tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 15000 aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc 15060 atgtctggat ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag 15120 gaagctgagt tggctgctgc caccgctgag caataactat cataacccct aggagatccg 15180 aaccagataa gtgaaatcta gttccaaact attttgtcat ttttaatttt cgtattagct 15240 tacgacgcta cacccagttc ccatctattt tgtcactctt ccctaaataa tccttaaaaa 15300 ctccatttcc acccctccca gttcccaact attttgtccg cccaca 15346 <210> 72 <211> 5329 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 72 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatggc 2700 cccctcccac gtggacaagg tgaacacccg cacctggtcc gcctccatcg tgttcatggt 2760 gctgaccttc gtgaacgtgt ccgtgcacct ggtgctgtcc aacttccccc acctgggcta 2820 cccctgcgtg tactaccacg tggtggactt cgagcgcctg aacatgtccg cctacaacgt 2880 gatgcacctg cacaccccca tgctgttcct ggactccgtg cagctggtgt gctacgccgt 2940 gttcatgcag ctggtgttcc tggccgtgac catctactac ctggtgtgct ggatcaagat 3000 ctccatgcgc aaggacaagg gcatgtccct gaaccagtcc acccgcgaca tctcctacat 3060 gggcgactcc ctgaccgcct tcctgttcat cctgtccatg gacaccttcc agctgttcac 3120 cctgaccatg tccttccgcc tgccctccat gatcgccttc atggccgccg tgcacttctt 3180 ctgcctgacc atcttcaacg tgtccatggt gacccagtac cgctcctaca agcgctccct 3240 gttcttcttc tcccgcctgc accccaagct gaagggcacc gtgcagttcc gcaccctgat 3300 cgtgaacctg gtggaggtgg ccctgggctt caacaccacc gtggtggcca tggccctgtg 3360 ctacggcttc ggcaacaact tcttcgtgcg caccggccac atggtgctgg ccgtgttcgt 3420 ggtgtacgcc atcatctcca tcatctactt cctgctgatc gaggccgtgt tcttccagta 3480 cgtgaaggtg cagttcggct accacctggg cgccttcttc ggcctgtgcg gcctgatcta 3540 ccccatcgtg cagtacgaca ccttcctgtc caacgagtac cgcaccggca tctcctggtc 3600 cttcggcatg ctgttcttca tctgggccat gttcaccacc tgccgcgccg tgcgctactt 3660 ccgcggccgc ggctccggct ccgtgaagta ccaggccctg gccaccgcct ccggcgagga 3720 ggtggccgcc ctgtcccacc acgactccct ggagtcccgc cgcctgcgcg aggaggagga 3780 cgacgacgac gacgaggact tcgaggacgc ctaagagctc aagcttgtcg agaagtacta 3840 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 3900 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 3960 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 4020 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 4080 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 4140 agttggctgc tgtggctagc tttgtttaac tttaagaagg agatacatct agaaatatta 4200 atagatcatg gagataatta aaatgataac catctcgcaa ataaataagt attttactgt 4260 tttcgtaaca gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc 4320 accatcgggc gcggatcccg gtccgaagcg cgcggaattc aaaggcctac gccaccatgg 4380 agtggaacac actagtacta ggtcttttgg ttttatcggt agcggcaagt tccaaccata 4440 cgtcgactgc tagcacaccg agtccctcta gctctactca cacctcaacg accgtgaagg 4500 caacgactac tgcgacaact agtacaacta cggtgacaag tacgacttca tcaacgacta 4560 gtaccaaacc cggttccacc actcacgacc ccaatgtgat gagaccacat gctcacaatg 4620 atttttacaa ggcgcattgt acatcgcata tgtatgaact ttctctgtcc agctttgcgg 4680 cctggtggac tatgcttaat gctctcattc tcatgggagc tttttgtatc gtactacgac 4740 attgctgttt ccagaacttt actgcaacca ccaccaaagg ctattgataa aagcttgtcg 4800 agaagtacta gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa 4860 aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta 4920 acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa 4980 ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt 5040 atcatgtctg gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga 5100 aaggaagctg agttggctgc tgccaccgct gagcaataac tatcataacc cctaggagat 5160 ccgaaccaga taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta 5220 gcttacgacg ctacacccag ttcccatcta ttttgtcact cttccctaaa taatccttaa 5280 aaactccatt tccacccctc ccagttccca actattttgt ccgcccaca 5329 <210> 73 <211> 18685 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 73 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggtttgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatggc 2700 cccctcccac gtggacaagg tgaacacccg cacctggtcc gcctccatcg tgttcatggt 2760 gctgaccttc gtgaacgtgt ccgtgcacct ggtgctgtcc aacttccccc acctgggcta 2820 cccctgcgtg tactaccacg tggtggactt cgagcgcctg aacatgtccg cctacaacgt 2880 gatgcacctg cacaccccca tgctgttcct ggactccgtg cagctggtgt gctacgccgt 2940 gttcatgcag ctggtgttcc tggccgtgac catctactac ctggtgtgct ggatcaagat 3000 ctccatgcgc aaggacaagg gcatgtccct gaaccagtcc acccgcgaca tctcctacat 3060 gggcgactcc ctgaccgcct tcctgttcat cctgtccatg gacaccttcc agctgttcac 3120 cctgaccatg tccttccgcc tgccctccat gatcgccttc atggccgccg tgcacttctt 3180 ctgcctgacc atcttcaacg tgtccatggt gacccagtac cgctcctaca agcgctccct 3240 gttcttcttc tcccgcctgc accccaagct gaagggcacc gtgcagttcc gcaccctgat 3300 cgtgaacctg gtggaggtgg ccctgggctt caacaccacc gtggtggcca tggccctgtg 3360 ctacggcttc ggcaacaact tcttcgtgcg caccggccac atggtgctgg ccgtgttcgt 3420 ggtgtacgcc atcatctcca tcatctactt cctgctgatc gaggccgtgt tcttccagta 3480 cgtgaaggtg cagttcggct accacctggg cgccttcttc ggcctgtgcg gcctgatcta 3540 ccccatcgtg cagtacgaca ccttcctgtc caacgagtac cgcaccggca tctcctggtc 3600 cttcggcatg ctgttcttca tctgggccat gttcaccacc tgccgcgccg tgcgctactt 3660 ccgcggccgc ggctccggct ccgtgaagta ccaggccctg gccaccgcct ccggcgagga 3720 ggtggccgcc ctgtcccacc acgactccct ggagtcccgc cgcctgcgcg aggaggagga 3780 cgacgacgac gacgaggact tcgaggacgc ctaagagctc aagcttgtcg agaagtacta 3840 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 3900 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 3960 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 4020 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 4080 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 4140 agttggctgc tgtggctagc tttgtttaac tttaagaagg agatacatct agaaatatta 4200 atagatcatg gagataatta aaatgataac catctcgcaa ataaataagt attttactgt 4260 tttcgtaaca gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc 4320 accatcgggc gcggatcccg gtccgaagcg cgcggaattc aaaggcctac gccaccatgg 4380 agtggaacac actagtacta ggtcttttgg ttttatcggt agcggcaagt tccaaccata 4440 cgtcgactgc tagcacaccg agtccctcta gctctactca cacctcaacg accgtgaagg 4500 caacgactac tgcgacaact agtacaacta cggtgacaag tacgacttca tcaacgacta 4560 gtaccaaacc cggttccacc actcacgacc ccaatgtgat gagaccacat gctcacaatg 4620 atttttacaa ggcgcattgt acatcgcata tgtatgaact ttctctgtcc agctttgcgg 4680 cctggtggac tatgcttaat gctctcattc tcatgggagc tttttgtatc gtactacgac 4740 attgctgttt ccagaacttt actgcaacca ccaccaaagg ctattgataa aagcttgtcg 4800 agaagtacta gagaagcttg tcgagaagta ctagaggatc ataatcagcc ataccacatt 4860 tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa 4920 aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag 4980 caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt 5040 gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg agcctagaag 5100 atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat 5160 aactatcata acccctaggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag 5220 gaactatatc cggatctgaa caggagggac agctgataga aacagaagcc actggagcac 5280 ctcaaaaaca ccatcataca ctaaatcagt aagttggcag catcacccga cgcactttgc 5340 gccgaataaa tacctgtgac ggaagatcac ttcgcagaat aaataaatcc tggtgtccct 5400 gttgataccg ggaagccctg ggccaacttt tggcgaaaat gagacgttga tcggcacgta 5460 agaggttcca actttcacca taatgaaata agatcactac cgggcgtatt ttttgagtta 5520 tcgagatttt caggagctaa ggaagctaaa atggagaaaa aaatcactgg atataccacc 5580 gttgatatat cccaatggca tcgtaaagaa cattttgagg catttcagtc agttgctcaa 5640 tgtacctata accagaccgt tcagctggat attacggcct ttttaaagac cgtaaagaaa 5700 aataagcaca agttttatcc ggcctttatt cacattcttg cccgcctgat gaatgctcat 5760 ccggaattcc gtatggcaat gaaagacggt gagctggtga tatgggatag tgttcaccct 5820 tgttacaccg ttttccatga gcaaactgaa acgttttcat cgctctggag tgaataccac 5880 gacgatttcc ggcagtttct acacatatat tcgcaagatg tggcgtgtta cggtgaaaac 5940 ctggcctatt tccctaaagg gtttattgag aatatgtttt tcgtctcagc caatccctgg 6000 gtgagtttca ccagttttga tttaaacgtg gccaatatgg acaacttctt cgcccccgtt 6060 ttcaccatgg gcaaatatta tacgcaaggc gacaaggtgc tgatgccgct ggcgattcag 6120 gttcatcatg ccgtttgtga tggcttccat gtcggcagaa tgcttaatga attacaacag 6180 tactgcgatg agtggcaggg cggggcgtaa tttttttaag gcagttattg gtgcccttaa 6240 acgcctggtt gctacgcctg aataagtgat aataagcgga tgaatggcag aaattcgaaa 6300 gcaaattcga cccggtcgtc ggttcagggc agggtcgtta aatagccgct tatgtctatt 6360 gctggtttac cggtttattg actaccggaa gcagtgtgac cgtgtgcttc tcaaatgcct 6420 gaggccagtt tgctcaggct ctccccgtgg aggtaataat tgacgatatg atcatttatt 6480 ctgcctccca gctgacattc atccggggtc agcaccgttt ctgcggactg gctttctacg 6540 tgttccgctt cctttagcag cccttgcgcc ctgagtgctt gcggcagcgt gaagctaatt 6600 ctgtcagccg ttaagtgttc ctgtgtcact caaaattgct ttgagaggct ctaagggctt 6660 ctcagtgcgt tacatccctg gcttgttgtc cacaaccgtt aaaccttaaa agctttaaaa 6720 gccttatata ttcttttttt tcttataaaa cttaaaacct tagaggctat ttaagttgct 6780 gatttatatt aattttattg ttcaaacatg agagcttagt acgtgaaaca tgagagctta 6840 gtacgttagc catgagagct tagtacgtta gccatgaggg tttagttcgt taaacatgag 6900 agcttagtac gttaaacatg agagcttagt acgtgaaaca tgagagctta gtacgtacta 6960 tcaacaggtt gaactgctga tcaacagatc ctctacgcgg ccgcggtacc ataacttcgt 7020 atagcataca ttatacgaag ttatctggtt taaacgtacc cgtagtggct atggcagggc 7080 ttgccgcccc gacgttggct gcgagccctg ggccttcacc cgaacttggg ggttggggtg 7140 gggaaaagga agaaacgcgg gcgtattggt cccaatgggg tctcggtggg gtatcgacag 7200 agtgccagcc ctgggaccga accccgcgtt tatgaacaaa cgacccaaca cccgtgcgtt 7260 ttattctgtc tttttattgc cgtcatagcg cgggttcctt ccggtattgt ctccttccgt 7320 gtttcagtta gcctccccca tctcccggta ccgcatgcta tgcatcagct gctagcacca 7380 tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat tgtaaataaa atgtaattta 7440 cagtatagta ttttaattaa tatacaaatg atttgataat aattcttatt taactataat 7500 atattgtgtt gggttgaatt aaaggtccgt atactagtat cgattcgcga cctactccgg 7560 aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt 7620 ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata 7680 ccgtcccacc atcgggcgcg gatccgccac catggaaaac tggtccgctc tggaactgct 7740 gcccaaggtc ggaatcccta ccgacttcct gacccacgtc aagacctccg ctggcgagga 7800 aatgttcgag gctctgagga tctactacgg cgacgacccc gagcgttaca acatccactt 7860 cgaggctatc ttcggcacct tctgcaaccg tctggaatgg gtgtacttcc tgacttccgg 7920 cctggctgct gctgctcacg ctatcaagtt ccacgacctg aacaagctga ccaccggcaa 7980 gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt gctggcctgc ctacctcccg 8040 tcagaccacc atcatggtca ccaagtactc cgagaagtcc cccatcacca tccctttcga 8100 gctgtccgct gcttgcctga cttacctgcg tgaaaccttc gagggcacca tcctggacaa 8160 gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct ctgaagaaca ccgctgacgc 8220 tatggaacgt ggcctgatcc acagcttcct ccagaccctg ctgaggaagg ctccccccta 8280 cttcgtggtg cagaccctgg tcgagaacgc taccctggct cgtcaggctc tgaaccgtat 8340 ccagcgctcc aacatcctgc agtccttcaa ggctaagatg ctggctaccc tgttcctgct 8400 gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg acccgtctgg ctgaggctgc 8460 taccgactcc atcctcgaca accctactac ctacaccacc tcctccggtg ctaagatctc 8520 cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc atgtccctgc tgtcctccca 8580 catcactaag gaaaccgtgt ccgctcccgc tacctacggc aacttcgtgc tgtcccccga 8640 gaacgctgtg accgctatct cctaccactc tatcctggct gacttcaact cctacaaggc 8700 tcacctgacc tccggccagc cccacctccc caacgactcc ctgagccagg ctggtgctca 8760 ctccctgacc cccctgtcca tggacgtgat ccgtctgggc gaaaagaccg tgatcatgga 8820 aaacctgcgt cgcgtgtaca agaacaccga caccaaggac cccctggaac gtaacgtgga 8880 cctgaccttc ttcttccccg tgggcctgta cctgcccgag gaccgtggtt acaccaccgt 8940 cgagtccaag gtcaagctga acgacaccgt gcgtaacgct ctgcccacca ccgcttacct 9000 gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg gacgctctca agaccctgtg 9060 ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct ttcaccgagc gtggtccccc 9120 atccgagccc gctatgcagc gtctgctgga atgccgtttc cagcaagagc ccatgggtgg 9180 tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc gaggtgcccc gtaccgtgaa 9240 cgagatgaag caggacttcg tggtcaccga cttctacaag gttggaaaca tcaccctgta 9300 caccgagctg caccctttct tcgacttcac ccactgccaa gagaactccg agactgtggc 9360 tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac ggcctggctc ccggtccctt 9420 ccacgagctg aggacctggg agatcatgga acacatgcgc ctgcgtcccc cacccgacta 9480 cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc cccaactacc ccgagctgtg 9540 ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct ttcctgctga tccgcgcttt 9600 catcgctcgt tgcatcgtga acatgttcca cacccgtcag ctgctggtgt tcgctcactc 9660 ctacgctctg gtcaccctga tcgctgagca cctggctgac ggtgctctgc ccccccagct 9720 cctgttccac taccgtaacc tggtggctgt gctgcgcctg gtcacccgta tctccgctct 9780 gcccggcctg aacaacggcc agctggctga ggaacccctg tccgcttacg tgaacgctct 9840 gcacgaccac aggctgtggc cccccttcgt gacccacctc cctcgtaaca tggaaggtgt 9900 ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac atcgaggctc gtcaccacgg 9960 tgtctccgac gtgccccgtc tgggtgctat ggacgctgac gagcccctgt tcgtggacga 10020 ctaccgtgct accgacgacg agtggaccct gcaaaaggtg ttctacctgt gcctgatccc 10080 cgctatgacc aacaaccgtg cttgcggcct gggcctgaac ctcaagactc tgctggtgga 10140 cctgttctac cgtcccgcct tcctgctcat gcccgctgct accgctgtgt ccacctccgg 10200 caccacctcc aaggaatcca cctctggtgt cacccccgag gactccgtgg ctgctcagcg 10260 tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac gtggccaccg acgctcacac 10320 ccctctgctg caggcttgcc gcgagctgtt cctggctgtg cagttcgtgg gcgagcacgt 10380 gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag aggcagggac tgcccgactt 10440 catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc gtgaccgctc ctaagaccct 10500 gatcgagtac tccctgcccg tgcccttcca ccgtttctac tccaacccca ccatctgcgc 10560 tgctctgtcc gacgacatca agcgttacgt gaccgagttc ccccactacc atagacacga 10620 tggtggtttc cccctgccca ccgctttcgc tcacgagtac cacaactggc tgcgtagccc 10680 cttctcccgt tactccgcta cctgccccaa cgtgctgcac tccgtgatga ccctggctgc 10740 tatgctgtac aagatctccc ccgtgtccct ggtgctgcag accaaggctc acatccaccc 10800 cggtttcgct ctgaccgctg tgcgtaccga caccttcgag gtggacatgc tgctgtactc 10860 cggcaagtcc tgcacctccg tcatcatcaa caaccccatc gtgaccaagg aagagaggga 10920 catctccacc acctaccacg tgacccagaa catcaacacc gtggacatgg gcctgggtta 10980 cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc accgacatgg gtgtccgtgt 11040 gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc cacgatgagg tggaccgttg 11100 gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg gacaccgaga ctatctccat 11160 gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct accgtgcacg gccagaaggc 11220 tgtctgcgag ctgatcctga cccctgtgac tatggacgtg aactacttca agatcaccaa 11280 caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac ccctacgaca ccgaggctgc 11340 caccaaggct atctacgacc accgcgaggc tgacgctcag accttcgctg ctacccacaa 11400 cccatgggct tcccaggctg gttgcctgtc cgacgtcctg tacaacaccc gtcaccgcga 11460 gcgtctgggc tacaactcca agttctactc cccctgcgct cagtacttca acaccgagga 11520 aatcatcgct gccaacaaga ccctcttcaa gaccatcgac gagtacctgc tgcgcgctaa 11580 ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc gtcgagggaa ccgagcagct 11640 gatcgagaac ccttgccgtc tgacccaaga ggctctgccc atcctgtcca ccaccaccct 11700 ggctctgatg gaaactaagc tgaagggtgg cgctggtgct ttcgctacct ccgagactca 11760 cttcggcaac tacgtcgtgg gagagatcat ccccctgcag cagtccatgc tgttcaacag 11820 ctaagagctc aagcttgtcg agaagtacta gaggatcata atcagccata ccacatttgt 11880 agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 11940 gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 12000 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 12060 caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctagaagatc 12120 cggctgctaa caaagcccga aaggaagctg agttggctgc tgtggctagc tttgtttaac 12180 tttaagaagg agatacatct agaccggaat attaatagat catggagata attaaaatga 12240 taaccatctc gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa 12300 acctataaat attccggatt attcataccg tcccaccatc gggcgcggat cccggtccga 12360 agcgcgcgga attcaaaggc ctacgtcgac gccaccatgg aatcccgtgg tcgtcgttgc 12420 cccgagatga tctccgtgct gggtcccatc tccggtcacg tcctgaaggc tgtgttctcc 12480 cgtggcgaca cccccgtgct gccccacgaa actcgtctgc tgcagaccgg tatccacgtg 12540 cgtgtgtccc agccctccct gatcctggtg tcccagtaca cccccgactc caccccttgc 12600 caccgcggag acaaccagct gcaggtccag cacacctact tcaccggttc cgaggtcgag 12660 aacgtgtccg tgaacgtgca caaccccacc ggtcgttcca tctgcccctc ccaagagccc 12720 atgtccatct acgtgtacgc tctgcccctg aagatgctga acatcccctc catcaacgtg 12780 caccactacc cctccgctgc tgagcgcaag caccgtcacc tccccgtggc tgacgctgtg 12840 atccacgctt ccggcaagca gatgtggcag gctcgtctga ccgtgtccgg cctggcttgg 12900 acccgtcagc agaaccagtg gaaggaaccc gacgtgtact acacctccgc tttcgtgttc 12960 cccaccaagg acgtggccct gcgtcacgtc gtgtgcgctc acgaactcgt gtgctccatg 13020 gaaaacaccc gtgctaccaa gatgcaagtg atcggcgacc agtacgtgaa ggtgtacctg 13080 gaatccttct gcgaggacgt gccctccggc aagctgttca tgcacgtgac cctgggttcc 13140 gacgtggaag aggacctgac catgacccgt aacccccagc ccttcatgcg tccccacgag 13200 cgtaacggtt tcaccgtgct gtgccccaag aacatgatca tcaagcccgg caagatctcc 13260 cacatcatgc tggacgtggc cttcacctcc cacgagcact tcggcctgct gtgccctaag 13320 tccatccccg gcctgtccat ctccggcaac ctgctgatga acggccagca gatcttcctg 13380 gaagtgcagg ctatccgtga aaccgtcgag ctgcgtcagt acgaccctgt ggctgctctg 13440 ttcttcttcg acatcgacct gctgctgcag cgtggtcccc agtactccga gcaccccacc 13500 ttcaccagcc agtaccgtat ccagggcaag ctggaatacc gtcacacctg ggaccgtcac 13560 gacgagggtg ctgctcaggg cgacgacgac gtgtggacct ccggttccga ctccgacgag 13620 gaactggtca ccaccgagcg caagaccccc cgtgtgaccg gtggtggtgc tatggctggt 13680 gcttccacct ccgctggtcg caagcgcaag tccgcttcct ccgctaccgc ttgcaccgct 13740 ggtgtcatga cccgtggtcg cctgaaggct gagtccaccg tggctcccga agaggacact 13800 gacgaggact ccgacaacga gatccacaac cccgctgtgt tcacctggcc cccctggcag 13860 gctggtatcc tggctcgtaa cctggtgccc atggtggcta ccgtgcaggg ccagaacctg 13920 aagtaccaag agttcttctg ggacgccaac gacatctacc gtatcttcgc tgagctggaa 13980 ggcgtgtggc agcccgctgc tcagcccaag cgtcgtcgtc accgtcagga cgctctgcct 14040 ggtccctgta tcgcttccac ccccaagaag caccgcggct aaaagcttgt cgagaagtac 14100 tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc 14160 ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 14220 attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 14280 tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 14340 tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc 14400 tgagttggct gctgccaccg ctgagcaata actatcataa ccggaatatt aatagatcat 14460 ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac 14520 agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg 14580 cgcggatccc ggtccgaagc gcgcggaatt cgccaccatg accatggacg agcagcagcc 14640 ccaggctgtg acccccgtgt acgtgggcgg tttcctggct cgttacgacc agtcccccga 14700 cgaggctgag ctgctgctgc cacgtgacgt ggtcgaacac tggctgcacg ctcagggcca 14760 gggacagcct tccctgtccg tggctctgcc cctgaacatc aaccacgacg acaccgctgt 14820 cgtgggtcac gtggccgcta tgcagtccgt gcgtgacggc ctgttctgcc tgggttgcgt 14880 gacctccccc cgtttcctgg aaatcgtgcg tcgtgcttcc gagaagtccg agctggtgtc 14940 ccgtggtccc gtgtccccac tgcagcccga caaggtggtc gagttcctgt ccggttccta 15000 cgctggcctg tccctgtcat cccgtcgttg cgacgacgtc gaggctgcta cctccctgag 15060 cggctccgag actaccccct tcaagcacgt ggccctgtgc tccgtgggtc gtaggcgtgg 15120 aaccctggct gtgtacggtc gtgaccccga gtgggtcacc cagcgtttcc ccgacctgac 15180 cgctgctgac cgtgacggac tgcgtgctca gtggcagcgt tgcggttcca ccgctgtgga 15240 cgcttccggc gaccccttcc gttccgactc ctacggcctg ctgggcaact ccgtggacgc 15300 tctgtacatc cgcgagcgtc tgcccaagct gcgttacgac aagcagctcg tgggtgtcac 15360 cgagcgcgag tcctacgtga aggcttccgt gtcccccgag gctgcttgcg acatcaaggc 15420 tgcttccgct gagcgttctg gcgacagccg ctcccaggct gctactcctg ctgctggtgc 15480 tcgtgtgccc tccagctccc catccccacc tgtcgagcct ccctcccccg tgcaacctcc 15540 tgctctgcct gcttccccct ccgtgctgcc tgctgagtcc agcccctccc tgtcaccctc 15600 tgagcctgct gaggctgcct ccatgtccca ccctctgagc gctgctgtga ctgctgctac 15660 cgctccccct ggtgctactg tggctggtgc ttcccccgct gtgccttccc tggcttggcc 15720 tcacgacggt gtctacctgc ccaaggacgc tttcttctcc ctgctgggcg cttcccgttc 15780 cgctgctccc gtgatgtacc ccggtgctgt ggctgctccc cccagcgctt cacctgctcc 15840 tctgcccctg ccctcctacc ccgcttccta cggtgctccc gtcgtgggtt acgaccagct 15900 ggctgctcgt cacttcgctg actacgtgga cccccactac cccggctggg gtcgtcgtta 15960 cgagcccgct ccttccctgc acccatccta ccctgtgccc cctcctccat cacccgctta 16020 ctaccgtcgt cgtgactccc ccggtggcat ggacgagcct ccatctggat gggagcgtta 16080 cgacggttcc caccgtggcc agtcccaaaa gcagcaccgt cacggtggtt ccggtggtca 16140 caacaagcgt cgcaaggaag ccgctgctgc atcctccagc tccgacgagg acctgagctt 16200 ccccggcgag gctgaacacg gtcgtgctcg caagcgtctg aagtcccacg tgaactccga 16260 cggaggtagc ggaggccacg ctggttccaa ccagcagcag caacagcgct acgacgagct 16320 gcgtgacgct atccacgagc tgaagcgtga cctgttcgct gctcgccagt cctccaccct 16380 gctgtctgct gctctgccag ctgccgcttc ttcctcccct accaccacca ccgtgtgcac 16440 ccctactggc gagctgacct ctggtggtgg cgagactccc accgctctgc tgtccggtgg 16500 tgctaaggtg gccgagcgtg ctcaggctgg tgtcgtgaac gcttcctgcc gtctggctac 16560 cgcttccggt tccgaggctg ccaccgctgg tccctctacc gctggttcct catcctgccc 16620 agcttccgtg gtgctggctg ccgctgctgc tcaagccgcc gctgcttcac agtccccccc 16680 aaaggatatg gtggacctga accgtcgtat cttcgtggct gctctgaaca agctcgagta 16740 ataaaagctt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 16800 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 16860 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 16920 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 16980 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 17040 ctaacaaagc ccgaaaggaa gctgggaata ttaatagatc atggagataa ttaaaatgat 17100 aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa 17160 cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc cgccaccatg 17220 gctgctatgg aagctaacat cttctgcacc ttcgaccaca agctgtctat cgctgacgtg 17280 ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc cccagcgtct gcacctgatc 17340 aagcactacc agctgggcct gcaccagttc gtggaccaca cccgtggtta cgtgcgtctg 17400 cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc gtgtcgaggg caaccagatc 17460 ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc tgaacaccgg tcccgtgacc 17520 tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt tccacggtcc cctggctcgt 17580 gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc cctggatcgt gcccatgccc 17640 ctggctctgg aaatcaacca gcgcctgctg atcatgggcc tgttctccct ggaccgttcc 17700 tacgaagaag tgaaggctgc tgtccagcag ctgcagacca tcaccttccg tgacgctacc 17760 ttcaccatcc ccgaccccgt gatcgaccag cacctcctga tcgacatgaa gaccgcttgc 17820 ctgtccatgt ccatggtggc taacctggct tccgagctga ccatgaccta cgtccgcaag 17880 ctggctttgg aggactcttc catgctgctg gtcaagtgcc aagagctgct gatgcgtctg 17940 gaccgcgagc gttccgtggg cgagcctcgt actcccgctc gtcctcagca cgtgtccccc 18000 gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc tgcgtcagct ggacgacctg 18060 atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc cagacaacaa gtccgctacc 18120 tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa gtactagagg atcataatca 18180 gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 18240 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 18300 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 18360 ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc 18420 ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc 18480 accgctgagc aataactatc ataaccccta ggagatccga accagataag tgaaatctag 18540 ttccaaacta ttttgtcatt tttaattttc gtattagctt acgacgctac acccagttcc 18600 catctatttt gtcactcttc cctaaataat ccttaaaaac tccatttcca cccctcccag 18660 ttcccaacta ttttgtccgc ccaca 18685 <210> 74 <211> 15813 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 74 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaccg gaatattaat 7200 agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt 7260 tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac 7320 catcgggcgc ggatcccggt ccgaagcgcg cggaattcaa aggcctacgt cgacgccacc 7380 atggaatccc gtggtcgtcg ttgccccgag atgatctccg tgctgggtcc catctccggt 7440 cacgtcctga aggctgtgtt ctcccgtggc gacacccccg tgctgcccca cgaaactcgt 7500 ctgctgcaga ccggtatcca cgtgcgtgtg tcccagccct ccctgatcct ggtgtcccag 7560 tacacccccg actccacccc ttgccaccgc ggagacaacc agctgcaggt ccagcacacc 7620 tacttcaccg gttccgaggt cgagaacgtg tccgtgaacg tgcacaaccc caccggtcgt 7680 tccatctgcc cctcccaaga gcccatgtcc atctacgtgt acgctctgcc cctgaagatg 7740 ctgaacatcc cctccatcaa cgtgcaccac tacccctccg ctgctgagcg caagcaccgt 7800 cacctccccg tggctgacgc tgtgatccac gcttccggca agcagatgtg gcaggctcgt 7860 ctgaccgtgt ccggcctggc ttggacccgt cagcagaacc agtggaagga acccgacgtg 7920 tactacacct ccgctttcgt gttccccacc aaggacgtgg ccctgcgtca cgtcgtgtgc 7980 gctcacgaac tcgtgtgctc catggaaaac acccgtgcta ccaagatgca agtgatcggc 8040 gaccagtacg tgaaggtgta cctggaatcc ttctgcgagg acgtgccctc cggcaagctg 8100 ttcatgcacg tgaccctggg ttccgacgtg gaagaggacc tgaccatgac ccgtaacccc 8160 cagcccttca tgcgtcccca cgagcgtaac ggtttcaccg tgctgtgccc caagaacatg 8220 atcatcaagc ccggcaagat ctcccacatc atgctggacg tggccttcac ctcccacgag 8280 cacttcggcc tgctgtgccc taagtccatc cccggcctgt ccatctccgg caacctgctg 8340 atgaacggcc agcagatctt cctggaagtg caggctatcc gtgaaaccgt cgagctgcgt 8400 cagtacgacc ctgtggctgc tctgttcttc ttcgacatcg acctgctgct gcagcgtggt 8460 ccccagtact ccgagcaccc caccttcacc agccagtacc gtatccaggg caagctggaa 8520 taccgtcaca cctgggaccg tcacgacgag ggtgctgctc agggcgacga cgacgtgtgg 8580 acctccggtt ccgactccga cgaggaactg gtcaccaccg agcgcaagac cccccgtgtg 8640 accggtggtg gtgctatggc tggtgcttcc acctccgctg gtcgcaagcg caagtccgct 8700 tcctccgcta ccgcttgcac cgctggtgtc atgacccgtg gtcgcctgaa ggctgagtcc 8760 accgtggctc ccgaagagga cactgacgag gactccgaca acgagatcca caaccccgct 8820 gtgttcacct ggcccccctg gcaggctggt atcctggctc gtaacctggt gcccatggtg 8880 gctaccgtgc agggccagaa cctgaagtac caagagttct tctgggacgc caacgacatc 8940 taccgtatct tcgctgagct ggaaggcgtg tggcagcccg ctgctcagcc caagcgtcgt 9000 cgtcaccgtc aggacgctct gcctggtccc tgtatcgctt ccacccccaa gaagcaccgc 9060 ggctaaaagc ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag 9120 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 9180 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 9240 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 9300 ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc 9360 tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactatc 9420 ataaccggaa tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa 9480 taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat 9540 tattcatacc gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcgccac 9600 catgaccatg gacgagcagc agccccaggc tgtgaccccc gtgtacgtgg gcggtttcct 9660 ggctcgttac gaccagtccc ccgacgaggc tgagctgctg ctgccacgtg acgtggtcga 9720 acactggctg cacgctcagg gccagggaca gccttccctg tccgtggctc tgcccctgaa 9780 catcaaccac gacgacaccg ctgtcgtggg tcacgtggcc gctatgcagt ccgtgcgtga 9840 cggcctgttc tgcctgggtt gcgtgacctc cccccgtttc ctggaaatcg tgcgtcgtgc 9900 ttccgagaag tccgagctgg tgtcccgtgg tcccgtgtcc ccactgcagc ccgacaaggt 9960 ggtcgagttc ctgtccggtt cctacgctgg cctgtccctg tcatcccgtc gttgcgacga 10020 cgtcgaggct gctacctccc tgagcggctc cgagactacc cccttcaagc acgtggccct 10080 gtgctccgtg ggtcgtaggc gtggaaccct ggctgtgtac ggtcgtgacc ccgagtgggt 10140 cacccagcgt ttccccgacc tgaccgctgc tgaccgtgac ggactgcgtg ctcagtggca 10200 gcgttgcggt tccaccgctg tggacgcttc cggcgacccc ttccgttccg actcctacgg 10260 cctgctgggc aactccgtgg acgctctgta catccgcgag cgtctgccca agctgcgtta 10320 cgacaagcag ctcgtgggtg tcaccgagcg cgagtcctac gtgaaggctt ccgtgtcccc 10380 cgaggctgct tgcgacatca aggctgcttc cgctgagcgt tctggcgaca gccgctccca 10440 ggctgctact cctgctgctg gtgctcgtgt gccctccagc tccccatccc cacctgtcga 10500 gcctccctcc cccgtgcaac ctcctgctct gcctgcttcc ccctccgtgc tgcctgctga 10560 gtccagcccc tccctgtcac cctctgagcc tgctgaggct gcctccatgt cccaccctct 10620 gagcgctgct gtgactgctg ctaccgctcc ccctggtgct actgtggctg gtgcttcccc 10680 cgctgtgcct tccctggctt ggcctcacga cggtgtctac ctgcccaagg acgctttctt 10740 ctccctgctg ggcgcttccc gttccgctgc tcccgtgatg taccccggtg ctgtggctgc 10800 tccccccagc gcttcacctg ctcctctgcc cctgccctcc taccccgctt cctacggtgc 10860 tcccgtcgtg ggttacgacc agctggctgc tcgtcacttc gctgactacg tggaccccca 10920 ctaccccggc tggggtcgtc gttacgagcc cgctccttcc ctgcacccat cctaccctgt 10980 gccccctcct ccatcacccg cttactaccg tcgtcgtgac tcccccggtg gcatggacga 11040 gcctccatct ggatgggagc gttacgacgg ttcccaccgt ggccagtccc aaaagcagca 11100 ccgtcacggt ggttccggtg gtcacaacaa gcgtcgcaag gaagccgctg ctgcatcctc 11160 cagctccgac gaggacctga gcttccccgg cgaggctgaa cacggtcgtg ctcgcaagcg 11220 tctgaagtcc cacgtgaact ccgacggagg tagcggaggc cacgctggtt ccaaccagca 11280 gcagcaacag cgctacgacg agctgcgtga cgctatccac gagctgaagc gtgacctgtt 11340 cgctgctcgc cagtcctcca ccctgctgtc tgctgctctg ccagctgccg cttcttcctc 11400 ccctaccacc accaccgtgt gcacccctac tggcgagctg acctctggtg gtggcgagac 11460 tcccaccgct ctgctgtccg gtggtgctaa ggtggccgag cgtgctcagg ctggtgtcgt 11520 gaacgcttcc tgccgtctgg ctaccgcttc cggttccgag gctgccaccg ctggtccctc 11580 taccgctggt tcctcatcct gcccagcttc cgtggtgctg gctgccgctg ctgctcaagc 11640 cgccgctgct tcacagtccc ccccaaagga tatggtggac ctgaaccgtc gtatcttcgt 11700 ggctgctctg aacaagctcg agtaataaaa gcttgtcgag aagtactaga ggatcataat 11760 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 11820 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 11880 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 11940 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 12000 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctggg aatattaata 12060 gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt 12120 cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc 12180 atcgggcgcg gatccgccac catggctgct atggaagcta acatcttctg caccttcgac 12240 cacaagctgt ctatcgctga cgtgggcaag ctgaccaagc tggtggctgc tgtggtgccc 12300 atcccccagc gtctgcacct gatcaagcac taccagctgg gcctgcacca gttcgtggac 12360 cacacccgtg gttacgtgcg tctgcgtggc ctgctgcgta acatgaccct gaccctgatg 12420 cgtcgtgtcg agggcaacca gatcctgctg cacgtgccca cccacggcct gctgtacacc 12480 gtgctgaaca ccggtcccgt gacctgggag aagggcgacg ctctgtgcgt gctgcccccc 12540 ctgttccacg gtcccctggc tcgtgaaaac ctgttgaccc tgggccagtg ggagctggtg 12600 ctgccctgga tcgtgcccat gcccctggct ctggaaatca accagcgcct gctgatcatg 12660 ggcctgttct ccctggaccg ttcctacgaa gaagtgaagg ctgctgtcca gcagctgcag 12720 accatcacct tccgtgacgc taccttcacc atccccgacc ccgtgatcga ccagcacctc 12780 ctgatcgaca tgaagaccgc ttgcctgtcc atgtccatgg tggctaacct ggcttccgag 12840 ctgaccatga cctacgtccg caagctggct ttggaggact cttccatgct gctggtcaag 12900 tgccaagagc tgctgatgcg tctggaccgc gagcgttccg tgggcgagcc tcgtactccc 12960 gctcgtcctc agcacgtgtc ccccgacgac gagatcgctc gtctgtccgc tctgttcgtg 13020 atgctgcgtc agctggacga cctgatccgc gagcaggtcg tgttcaccgt gtgcgacgtg 13080 agcccagaca acaagtccgc tacctgcatc ttcaagggcc agctgttgaa ttttgacctt 13140 cttaagcttg cgggagacgt cgagtccaac cctgggccca tggccccctc ccacgtggac 13200 aaggtgaaca cccgcacctg gtccgcctcc atcgtgttca tggtgctgac cttcgtgaac 13260 gtgtccgtgc acctggtgct gtccaacttc ccccacctgg gctacccctg cgtgtactac 13320 cacgtggtgg acttcgagcg cctgaacatg tccgcctaca acgtgatgca cctgcacacc 13380 cccatgctgt tcctggactc cgtgcagctg gtgtgctacg ccgtgttcat gcagctggtg 13440 ttcctggccg tgaccatcta ctacctggtg tgctggatca agatctccat gcgcaaggac 13500 aagggcatgt ccctgaacca gtccacccgc gacatctcct acatgggcga ctccctgacc 13560 gccttcctgt tcatcctgtc catggacacc ttccagctgt tcaccctgac catgtccttc 13620 cgcctgccct ccatgatcgc cttcatggcc gccgtgcact tcttctgcct gaccatcttc 13680 aacgtgtcca tggtgaccca gtaccgctcc tacaagcgct ccctgttctt cttctcccgc 13740 ctgcacccca agctgaaggg caccgtgcag ttccgcaccc tgatcgtgaa cctggtggag 13800 gtggccctgg gcttcaacac caccgtggtg gccatggccc tgtgctacgg cttcggcaac 13860 aacttcttcg tgcgcaccgg ccacatggtg ctggccgtgt tcgtggtgta cgccatcatc 13920 tccatcatct acttcctgct gatcgaggcc gtgttcttcc agtacgtgaa ggtgcagttc 13980 ggctaccacc tgggcgcctt cttcggcctg tgcggcctga tctaccccat cgtgcagtac 14040 gacaccttcc tgtccaacga gtaccgcacc ggcatctcct ggtccttcgg catgctgttc 14100 ttcatctggg ccatgttcac cacctgccgc gccgtgcgct acttccgcgg ccgcggctcc 14160 ggctccgtga agtaccaggc cctggccacc gcctccggcg aggaggtggc cgccctgtcc 14220 caccacgact ccctggagtc ccgccgcctg cgcgaggagg aggacgacga cgacgacgag 14280 gacttcgagg acgcctaaga gctcaagctt gtcgagaagt actagaggat cataatcagc 14340 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 14400 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 14460 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 14520 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 14580 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgtggc 14640 tagctttgtt taactttaag aaggagatac atctagaaat attaatagat catggagata 14700 attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt aacagttttg 14760 taataaaaaa acctataaat attccggatt attcataccg tcccaccatc gggcgcggat 14820 cccggtccga agcgcgcgga attcaaaggc ctacgccacc atggagtgga acacactagt 14880 actaggtctt ttggttttat cggtagcggc aagttccaac catacgtcga ctgctagcac 14940 accgagtccc tctagctcta ctcacacctc aacgaccgtg aaggcaacga ctactgcgac 15000 aactagtaca actacggtga caagtacgac ttcatcaacg actagtacca aacccggttc 15060 caccactcac gaccccaatg tgatgagacc acatgctcac aatgattttt acaaggcgca 15120 ttgtacatcg catatgtatg aactttctct gtccagcttt gcggcctggt ggactatgct 15180 taatgctctc attctcatgg gagctttttg tatcgtacta cgacattgct gtttccagaa 15240 ctttactgca accaccacca aaggctattg ataaaagctt gtcgagaagt actagaggat 15300 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 15360 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 15420 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 15480 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 15540 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 15600 ctgctgccac cgctgagcaa taactatcat aacccctagg agatccgaac cagataagtg 15660 aaatctagtt ccaaactatt ttgtcatttt taattttcgt attagcttac gacgctacac 15720 ccagttccca tctattttgt cactcttccc taaataatcc ttaaaaactc catttccacc 15780 cctcccagtt cccaactatt ttgtccgccc aca 15813 <210> 75 <211> 16020 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 75 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttactgcagc caccaccaca gggagttcag ggtggacagg 2400 ttcacagcac gacggtgctc agggggggtc aggttgccgt aggtggagga ctgcaggctg 2460 aagttacgga tctcagacag gaacagcagg gagtccaggt agtcccacat ggggtcgatg 2520 aaggtgcgct ggaaacgggt ggatggggag gtgggggtgg tcttgttgtt gtcggaagca 2580 gtctcgttct cgacgggcat ggtgtcgttg tagtacaggg aggacatgtc cagggtgccg 2640 tagatggtgt agggagtctc gttacggatc agcacgtgag tgttcttcat gaactcggac 2700 acagcggtac ggttacggtt gggcttgcag aagggctcgt cacggtaacg cagggtggtg 2760 tacacccagg tagccaggtc cttcagctga gtggtcagga tagacttcat gaagttctcg 2820 tcgggacggt aaccgatggt agaggtgggg atacgggtgg gcacgatggg ggagtaggtc 2880 acgttggtgg aaacgttgaa gatggtggag gtgtaggagg agtagggggt agtagtgctg 2940 acgcgggact tcttggagat ggacttcacg ggagcctgct tgcgcttcag cttgcgcatg 3000 gtgttcttca gcttggtgga gttgatgtac ttgggcacac ggaagatgtt acgggacata 3060 gcgttgacca ggtagaagga acgggtgcag ttgcgctgag cgtaacgcag cagcagagca 3120 gccaggccca ggaagtagat agtctgggag tccacgttga ccttggaggg gcccacgtac 3180 agcttggtgt tccaacgggg cacgttgaag aacatggggt tgaaggtggt gaagttgccg 3240 cagttttcct cgccggtgtt gttacgacgg gacacgttca gcatctcgga caggcaggtc 3300 atggagggga tggtgccgca agagggggga cggaaggtga tcttctggcc ggtgtggttg 3360 tactcggagt acacgtactt agcgggcttg cgcagctggg tggtgtggaa gtcgaaccac 3420 aggtgggtga tggagtggtt acggatggga ccagccagga tggagttggg ggggaactgc 3480 ttcatctcga cggtgatgtt gtacagcttc tgctggctgg ggaaggtgaa gaacttgtag 3540 tagtcgccgg tcttggaagc cagctcttgc aggatacgca gcttcagctg gcgttcctct 3600 tccttagcct tctgggactt cacacggaaa cgagccacag cgatcttgca gttgatgaag 3660 ctgaacagca ggaaggtcag ggacatcagg aagaacaggt tgaacacgcc acgcatctcg 3720 cccttgcgac ccatggtggc ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 3780 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 3840 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 3900 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 3960 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 4020 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat ggaaaactgg 4080 tccgctctgg aactgctgcc caaggtcgga atccctaccg acttcctgac ccacgtcaag 4140 acctccgctg gcgaggaaat gttcgaggct ctgaggatct actacggcga cgaccccgag 4200 cgttacaaca tccacttcga ggctatcttc ggcaccttct gcaaccgtct ggaatgggtg 4260 tacttcctga cttccggcct ggctgctgct gctcacgcta tcaagttcca cgacctgaac 4320 aagctgacca ccggcaagat gctgttccac gtgcaagtgc cccgtgtggc ttccggtgct 4380 ggcctgccta cctcccgtca gaccaccatc atggtcacca agtactccga gaagtccccc 4440 atcaccatcc ctttcgagct gtccgctgct tgcctgactt acctgcgtga aaccttcgag 4500 ggcaccatcc tggacaagat cctgaacgtc gaggctatgc acaccgtgct gcgtgctctg 4560 aagaacaccg ctgacgctat ggaacgtggc ctgatccaca gcttcctcca gaccctgctg 4620 aggaaggctc ccccctactt cgtggtgcag accctggtcg agaacgctac cctggctcgt 4680 caggctctga accgtatcca gcgctccaac atcctgcagt ccttcaaggc taagatgctg 4740 gctaccctgt tcctgctgaa ccgtacccgt gaccgtgact acgtgctgaa gttcctgacc 4800 cgtctggctg aggctgctac cgactccatc ctcgacaacc ctactaccta caccacctcc 4860 tccggtgcta agatctccgg tgtcatggtg tccaccgcta acgtgatgca gatcatcatg 4920 tccctgctgt cctcccacat cactaaggaa accgtgtccg ctcccgctac ctacggcaac 4980 ttcgtgctgt cccccgagaa cgctgtgacc gctatctcct accactctat cctggctgac 5040 ttcaactcct acaaggctca cctgacctcc ggccagcccc acctccccaa cgactccctg 5100 agccaggctg gtgctcactc cctgaccccc ctgtccatgg acgtgatccg tctgggcgaa 5160 aagaccgtga tcatggaaaa cctgcgtcgc gtgtacaaga acaccgacac caaggacccc 5220 ctggaacgta acgtggacct gaccttcttc ttccccgtgg gcctgtacct gcccgaggac 5280 cgtggttaca ccaccgtcga gtccaaggtc aagctgaacg acaccgtgcg taacgctctg 5340 cccaccaccg cttacctgct gaacagggac cgtgctgtgc aaaagatcga cttcgtggac 5400 gctctcaaga ccctgtgcca ccccgtgctg cacgagcctg ctccatgcct gcaggctttc 5460 accgagcgtg gtcccccatc cgagcccgct atgcagcgtc tgctggaatg ccgtttccag 5520 caagagccca tgggtggtgc tgctcgtcgt atcccccact tctaccgtgt gcgccgcgag 5580 gtgccccgta ccgtgaacga gatgaagcag gacttcgtgg tcaccgactt ctacaaggtt 5640 ggaaacatca ccctgtacac cgagctgcac cctttcttcg acttcaccca ctgccaagag 5700 aactccgaga ctgtggctct gtgcaccccc cgtatcgtga tcggcaacct gcccgacggc 5760 ctggctcccg gtcccttcca cgagctgagg acctgggaga tcatggaaca catgcgcctg 5820 cgtcccccac ccgactacga ggaaaccctg cgtctgttca agaccaccgt gacctccccc 5880 aactaccccg agctgtgcta cctggtggac gtgctggtgc acggcaacgc tgacgctttc 5940 ctgctgatcc gcgctttcat cgctcgttgc atcgtgaaca tgttccacac ccgtcagctg 6000 ctggtgttcg ctcactccta cgctctggtc accctgatcg ctgagcacct ggctgacggt 6060 gctctgcccc cccagctcct gttccactac cgtaacctgg tggctgtgct gcgcctggtc 6120 acccgtatct ccgctctgcc cggcctgaac aacggccagc tggctgagga acccctgtcc 6180 gcttacgtga acgctctgca cgaccacagg ctgtggcccc ccttcgtgac ccacctccct 6240 cgtaacatgg aaggtgtcca ggtggtggct gatcgtcagc ccctgaaccc cgctaacatc 6300 gaggctcgtc accacggtgt ctccgacgtg ccccgtctgg gtgctatgga cgctgacgag 6360 cccctgttcg tggacgacta ccgtgctacc gacgacgagt ggaccctgca aaaggtgttc 6420 tacctgtgcc tgatccccgc tatgaccaac aaccgtgctt gcggcctggg cctgaacctc 6480 aagactctgc tggtggacct gttctaccgt cccgccttcc tgctcatgcc cgctgctacc 6540 gctgtgtcca cctccggcac cacctccaag gaatccacct ctggtgtcac ccccgaggac 6600 tccgtggctg ctcagcgtca ggctgtgggc gagatgctga ccgagctggt cgaggacgtg 6660 gccaccgacg ctcacacccc tctgctgcag gcttgccgcg agctgttcct ggctgtgcag 6720 ttcgtgggcg agcacgtgaa ggtgctggaa gtgcgtgctc ccctggacca cgctcagagg 6780 cagggactgc ccgacttcat ctcccgtcag catgtgctgt acaacggttg ctgcgtcgtg 6840 accgctccta agaccctgat cgagtactcc ctgcccgtgc ccttccaccg tttctactcc 6900 aaccccacca tctgcgctgc tctgtccgac gacatcaagc gttacgtgac cgagttcccc 6960 cactaccata gacacgatgg tggtttcccc ctgcccaccg ctttcgctca cgagtaccac 7020 aactggctgc gtagcccctt ctcccgttac tccgctacct gccccaacgt gctgcactcc 7080 gtgatgaccc tggctgctat gctgtacaag atctcccccg tgtccctggt gctgcagacc 7140 aaggctcaca tccaccccgg tttcgctctg accgctgtgc gtaccgacac cttcgaggtg 7200 gacatgctgc tgtactccgg caagtcctgc acctccgtca tcatcaacaa ccccatcgtg 7260 accaaggaag agagggacat ctccaccacc taccacgtga cccagaacat caacaccgtg 7320 gacatgggcc tgggttacac ctccaacact tgcgtggcct acgtgaaccg cgtccgcacc 7380 gacatgggtg tccgtgtgca ggacctgttc cgtgtgttcc ccatgaacgt gtaccgccac 7440 gatgaggtgg accgttggat caggcacgct gctggcgtcg agcgtcccca gctgctggac 7500 accgagacta tctccatgct gaccttcggt tccatgtccg agcgcaacgc tgctgctacc 7560 gtgcacggcc agaaggctgt ctgcgagctg atcctgaccc ctgtgactat ggacgtgaac 7620 tacttcaaga tcaccaacaa ccctcgtggt cgtgcttcct gcatgctggg cgtggacccc 7680 tacgacaccg aggctgccac caaggctatc tacgaccacc gcgaggctga cgctcagacc 7740 ttcgctgcta cccacaaccc atgggcttcc caggctggtt gcctgtccga cgtcctgtac 7800 aacacccgtc accgcgagcg tctgggctac aactccaagt tctactcccc ctgcgctcag 7860 tacttcaaca ccgaggaaat catcgctgcc aacaagaccc tcttcaagac catcgacgag 7920 tacctgctgc gcgctaagga ctgcatccgt ggcgacaccg acactcagta cgtgtgcgtc 7980 gagggaaccg agcagctgat cgagaaccct tgccgtctga cccaagaggc tctgcccatc 8040 ctgtccacca ccaccctggc tctgatggaa actaagctga agggtggcgc tggtgctttc 8100 gctacctccg agactcactt cggcaactac gtcgtgggag agatcatccc cctgcagcag 8160 tccatgctgt tcaacagcta agagctcaag cttgtcgaga agtactagag gatcataatc 8220 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 8280 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 8340 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 8400 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 8460 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgt 8520 ggctagcttt gtttaacttt aagaaggaga tacatctaga ccggaatatt aatagatcat 8580 ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac 8640 agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg 8700 cgcggatccc ggtccgaagc gcgcggaatt caaaggccta cgtcgacgcc accatggaat 8760 cccgtggtcg tcgttgcccc gagatgatct ccgtgctggg tcccatctcc ggtcacgtcc 8820 tgaaggctgt gttctcccgt ggcgacaccc ccgtgctgcc ccacgaaact cgtctgctgc 8880 agaccggtat ccacgtgcgt gtgtcccagc cctccctgat cctggtgtcc cagtacaccc 8940 ccgactccac cccttgccac cgcggagaca accagctgca ggtccagcac acctacttca 9000 ccggttccga ggtcgagaac gtgtccgtga acgtgcacaa ccccaccggt cgttccatct 9060 gcccctccca agagcccatg tccatctacg tgtacgctct gcccctgaag atgctgaaca 9120 tcccctccat caacgtgcac cactacccct ccgctgctga gcgcaagcac cgtcacctcc 9180 ccgtggctga cgctgtgatc cacgcttccg gcaagcagat gtggcaggct cgtctgaccg 9240 tgtccggcct ggcttggacc cgtcagcaga accagtggaa ggaacccgac gtgtactaca 9300 cctccgcttt cgtgttcccc accaaggacg tggccctgcg tcacgtcgtg tgcgctcacg 9360 aactcgtgtg ctccatggaa aacacccgtg ctaccaagat gcaagtgatc ggcgaccagt 9420 acgtgaaggt gtacctggaa tccttctgcg aggacgtgcc ctccggcaag ctgttcatgc 9480 acgtgaccct gggttccgac gtggaagagg acctgaccat gacccgtaac ccccagccct 9540 tcatgcgtcc ccacgagcgt aacggtttca ccgtgctgtg ccccaagaac atgatcatca 9600 agcccggcaa gatctcccac atcatgctgg acgtggcctt cacctcccac gagcacttcg 9660 gcctgctgtg ccctaagtcc atccccggcc tgtccatctc cggcaacctg ctgatgaacg 9720 gccagcagat cttcctggaa gtgcaggcta tccgtgaaac cgtcgagctg cgtcagtacg 9780 accctgtggc tgctctgttc ttcttcgaca tcgacctgct gctgcagcgt ggtccccagt 9840 actccgagca ccccaccttc accagccagt accgtatcca gggcaagctg gaataccgtc 9900 acacctggga ccgtcacgac gagggtgctg ctcagggcga cgacgacgtg tggacctccg 9960 gttccgactc cgacgaggaa ctggtcacca ccgagcgcaa gaccccccgt gtgaccggtg 10020 gtggtgctat ggctggtgct tccacctccg ctggtcgcaa gcgcaagtcc gcttcctccg 10080 ctaccgcttg caccgctggt gtcatgaccc gtggtcgcct gaaggctgag tccaccgtgg 10140 ctcccgaaga ggacactgac gaggactccg acaacgagat ccacaacccc gctgtgttca 10200 cctggccccc ctggcaggct ggtatcctgg ctcgtaacct ggtgcccatg gtggctaccg 10260 tgcagggcca gaacctgaag taccaagagt tcttctggga cgccaacgac atctaccgta 10320 tcttcgctga gctggaaggc gtgtggcagc ccgctgctca gcccaagcgt cgtcgtcacc 10380 gtcaggacgc tctgcctggt ccctgtatcg cttccacccc caagaagcac cgcggctaaa 10440 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 10500 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 10560 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 10620 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 10680 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 10740 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccg 10800 gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat 10860 tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat 10920 accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcgc caccatgacc 10980 atggacgagc agcagcccca ggctgtgacc cccgtgtacg tgggcggttt cctggctcgt 11040 tacgaccagt cccccgacga ggctgagctg ctgctgccac gtgacgtggt cgaacactgg 11100 ctgcacgctc agggccaggg acagccttcc ctgtccgtgg ctctgcccct gaacatcaac 11160 cacgacgaca ccgctgtcgt gggtcacgtg gccgctatgc agtccgtgcg tgacggcctg 11220 ttctgcctgg gttgcgtgac ctccccccgt ttcctggaaa tcgtgcgtcg tgcttccgag 11280 aagtccgagc tggtgtcccg tggtcccgtg tccccactgc agcccgacaa ggtggtcgag 11340 ttcctgtccg gttcctacgc tggcctgtcc ctgtcatccc gtcgttgcga cgacgtcgag 11400 gctgctacct ccctgagcgg ctccgagact acccccttca agcacgtggc cctgtgctcc 11460 gtgggtcgta ggcgtggaac cctggctgtg tacggtcgtg accccgagtg ggtcacccag 11520 cgtttccccg acctgaccgc tgctgaccgt gacggactgc gtgctcagtg gcagcgttgc 11580 ggttccaccg ctgtggacgc ttccggcgac cccttccgtt ccgactccta cggcctgctg 11640 ggcaactccg tggacgctct gtacatccgc gagcgtctgc ccaagctgcg ttacgacaag 11700 cagctcgtgg gtgtcaccga gcgcgagtcc tacgtgaagg cttccgtgtc ccccgaggct 11760 gcttgcgaca tcaaggctgc ttccgctgag cgttctggcg acagccgctc ccaggctgct 11820 actcctgctg ctggtgctcg tgtgccctcc agctccccat ccccacctgt cgagcctccc 11880 tcccccgtgc aacctcctgc tctgcctgct tccccctccg tgctgcctgc tgagtccagc 11940 ccctccctgt caccctctga gcctgctgag gctgcctcca tgtcccaccc tctgagcgct 12000 gctgtgactg ctgctaccgc tccccctggt gctactgtgg ctggtgcttc ccccgctgtg 12060 ccttccctgg cttggcctca cgacggtgtc tacctgccca aggacgcttt cttctccctg 12120 ctgggcgctt cccgttccgc tgctcccgtg atgtaccccg gtgctgtggc tgctcccccc 12180 agcgcttcac ctgctcctct gcccctgccc tcctaccccg cttcctacgg tgctcccgtc 12240 gtgggttacg accagctggc tgctcgtcac ttcgctgact acgtggaccc ccactacccc 12300 ggctggggtc gtcgttacga gcccgctcct tccctgcacc catcctaccc tgtgccccct 12360 cctccatcac ccgcttacta ccgtcgtcgt gactcccccg gtggcatgga cgagcctcca 12420 tctggatggg agcgttacga cggttcccac cgtggccagt cccaaaagca gcaccgtcac 12480 ggtggttccg gtggtcacaa caagcgtcgc aaggaagccg ctgctgcatc ctccagctcc 12540 gacgaggacc tgagcttccc cggcgaggct gaacacggtc gtgctcgcaa gcgtctgaag 12600 tcccacgtga actccgacgg aggtagcgga ggccacgctg gttccaacca gcagcagcaa 12660 cagcgctacg acgagctgcg tgacgctatc cacgagctga agcgtgacct gttcgctgct 12720 cgccagtcct ccaccctgct gtctgctgct ctgccagctg ccgcttcttc ctcccctacc 12780 accaccaccg tgtgcacccc tactggcgag ctgacctctg gtggtggcga gactcccacc 12840 gctctgctgt ccggtggtgc taaggtggcc gagcgtgctc aggctggtgt cgtgaacgct 12900 tcctgccgtc tggctaccgc ttccggttcc gaggctgcca ccgctggtcc ctctaccgct 12960 ggttcctcat cctgcccagc ttccgtggtg ctggctgccg ctgctgctca agccgccgct 13020 gcttcacagt cccccccaaa ggatatggtg gacctgaacc gtcgtatctt cgtggctgct 13080 ctgaacaagc tcgagtaata aaagcttgtc gagaagtact agaggatcat aatcagccat 13140 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 13200 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 13260 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 13320 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 13380 cctagaagat ccggctgcta acaaagcccg aaaggaagct gggaatatta atagatcatg 13440 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 13500 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 13560 gcggatccgc caccatggct gctatggaag ctaacatctt ctgcaccttc gaccacaagc 13620 tgtctatcgc tgacgtgggc aagctgacca agctggtggc tgctgtggtg cccatccccc 13680 agcgtctgca cctgatcaag cactaccagc tgggcctgca ccagttcgtg gaccacaccc 13740 gtggttacgt gcgtctgcgt ggcctgctgc gtaacatgac cctgaccctg atgcgtcgtg 13800 tcgagggcaa ccagatcctg ctgcacgtgc ccacccacgg cctgctgtac accgtgctga 13860 acaccggtcc cgtgacctgg gagaagggcg acgctctgtg cgtgctgccc cccctgttcc 13920 acggtcccct ggctcgtgaa aacctgttga ccctgggcca gtgggagctg gtgctgccct 13980 ggatcgtgcc catgcccctg gctctggaaa tcaaccagcg cctgctgatc atgggcctgt 14040 tctccctgga ccgttcctac gaagaagtga aggctgctgt ccagcagctg cagaccatca 14100 ccttccgtga cgctaccttc accatccccg accccgtgat cgaccagcac ctcctgatcg 14160 acatgaagac cgcttgcctg tccatgtcca tggtggctaa cctggcttcc gagctgacca 14220 tgacctacgt ccgcaagctg gctttggagg actcttccat gctgctggtc aagtgccaag 14280 agctgctgat gcgtctggac cgcgagcgtt ccgtgggcga gcctcgtact cccgctcgtc 14340 ctcagcacgt gtcccccgac gacgagatcg ctcgtctgtc cgctctgttc gtgatgctgc 14400 gtcagctgga cgacctgatc cgcgagcagg tcgtgttcac cgtgtgcgac gtgagcccag 14460 acaacaagtc cgctacctgc atcttcaagg gctaaggcgc gccaagcttg tcgagaagta 14520 ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 14580 cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 14640 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 14700 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 14760 ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag 14820 ctgagttggc tgctgctgag tagtgcgcga gcaaaattta agctacaaca aggcacgcgt 14880 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 14940 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 15000 cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt caaaggccta 15060 cgccaccatg gagtggaaca cactagtact aggtcttttg gttttatcgg tagcggcaag 15120 ttccaaccat acgtcgactg ctagcacacc gagtccctct agctctactc acacctcaac 15180 gaccgtgaag gcaacgacta ctgcgacaac tagtacaact acggtgacaa gtacgacttc 15240 atcaacgact agtaccaaac ccggttccac cactcacgac cccaatgtga tgagaccaca 15300 tgctcacaat gatttttaca aggcgcattg tacatcgcat atgtatgaac tttctctgtc 15360 cagctttgcg gcctggtgga ctatgcttaa tgctctcatt ctcatgggag ctttttgtat 15420 cgtactacga cattgctgtt tccagaactt tactgcaacc accaccaaag gctattgata 15480 aaagcttgtc gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt 15540 acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat 15600 tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 15660 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 15720 caatgtatct tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta 15780 acaaagcccg aaaggaagct gagttggctg ctgccaccgc tgagcaataa ctatcataac 15840 ccctaggaga tccgaaccag ataagtgaaa tctagttcca aactattttg tcatttttaa 15900 ttttcgtatt agcttacgac gctacaccca gttcccatct attttgtcac tcttccctaa 15960 ataatcctta aaaactccat ttccacccct cccagttccc aactattttg tccgcccaca 16020 <210> 76 <211> 16719 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 76 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttactgcagc caccaccaca gggagttcag ggtggacagg 2400 ttcacagcac gacggtgctc agggggggtc aggttgccgt aggtggagga ctgcaggctg 2460 aagttacgga tctcagacag gaacagcagg gagtccaggt agtcccacat ggggtcgatg 2520 aaggtgcgct ggaaacgggt ggatggggag gtgggggtgg tcttgttgtt gtcggaagca 2580 gtctcgttct cgacgggcat ggtgtcgttg tagtacaggg aggacatgtc cagggtgccg 2640 tagatggtgt agggagtctc gttacggatc agcacgtgag tgttcttcat gaactcggac 2700 acagcggtac ggttacggtt gggcttgcag aagggctcgt cacggtaacg cagggtggtg 2760 tacacccagg tagccaggtc cttcagctga gtggtcagga tagacttcat gaagttctcg 2820 tcgggacggt aaccgatggt agaggtgggg atacgggtgg gcacgatggg ggagtaggtc 2880 acgttggtgg aaacgttgaa gatggtggag gtgtaggagg agtagggggt agtagtgctg 2940 acgcgggact tcttggagat ggacttcacg ggagcctgct tgcgcttcag cttgcgcatg 3000 gtgttcttca gcttggtgga gttgatgtac ttgggcacac ggaagatgtt acgggacata 3060 gcgttgacca ggtagaagga acgggtgcag ttgcgctgag cgtaacgcag cagcagagca 3120 gccaggccca ggaagtagat agtctgggag tccacgttga ccttggaggg gcccacgtac 3180 agcttggtgt tccaacgggg cacgttgaag aacatggggt tgaaggtggt gaagttgccg 3240 cagttttcct cgccggtgtt gttacgacgg gacacgttca gcatctcgga caggcaggtc 3300 atggagggga tggtgccgca agagggggga cggaaggtga tcttctggcc ggtgtggttg 3360 tactcggagt acacgtactt agcgggcttg cgcagctggg tggtgtggaa gtcgaaccac 3420 aggtgggtga tggagtggtt acggatggga ccagccagga tggagttggg ggggaactgc 3480 ttcatctcga cggtgatgtt gtacagcttc tgctggctgg ggaaggtgaa gaacttgtag 3540 tagtcgccgg tcttggaagc cagctcttgc aggatacgca gcttcagctg gcgttcctct 3600 tccttagcct tctgggactt cacacggaaa cgagccacag cgatcttgca gttgatgaag 3660 ctgaacagca ggaaggtcag ggacatcagg aagaacaggt tgaacacgcc acgcatctcg 3720 cccttgcgac ccatggtggc ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 3780 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 3840 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 3900 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 3960 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 4020 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat ggaaaactgg 4080 tccgctctgg aactgctgcc caaggtcgga atccctaccg acttcctgac ccacgtcaag 4140 acctccgctg gcgaggaaat gttcgaggct ctgaggatct actacggcga cgaccccgag 4200 cgttacaaca tccacttcga ggctatcttc ggcaccttct gcaaccgtct ggaatgggtg 4260 tacttcctga cttccggcct ggctgctgct gctcacgcta tcaagttcca cgacctgaac 4320 aagctgacca ccggcaagat gctgttccac gtgcaagtgc cccgtgtggc ttccggtgct 4380 ggcctgccta cctcccgtca gaccaccatc atggtcacca agtactccga gaagtccccc 4440 atcaccatcc ctttcgagct gtccgctgct tgcctgactt acctgcgtga aaccttcgag 4500 ggcaccatcc tggacaagat cctgaacgtc gaggctatgc acaccgtgct gcgtgctctg 4560 aagaacaccg ctgacgctat ggaacgtggc ctgatccaca gcttcctcca gaccctgctg 4620 aggaaggctc ccccctactt cgtggtgcag accctggtcg agaacgctac cctggctcgt 4680 caggctctga accgtatcca gcgctccaac atcctgcagt ccttcaaggc taagatgctg 4740 gctaccctgt tcctgctgaa ccgtacccgt gaccgtgact acgtgctgaa gttcctgacc 4800 cgtctggctg aggctgctac cgactccatc ctcgacaacc ctactaccta caccacctcc 4860 tccggtgcta agatctccgg tgtcatggtg tccaccgcta acgtgatgca gatcatcatg 4920 tccctgctgt cctcccacat cactaaggaa accgtgtccg ctcccgctac ctacggcaac 4980 ttcgtgctgt cccccgagaa cgctgtgacc gctatctcct accactctat cctggctgac 5040 ttcaactcct acaaggctca cctgacctcc ggccagcccc acctccccaa cgactccctg 5100 agccaggctg gtgctcactc cctgaccccc ctgtccatgg acgtgatccg tctgggcgaa 5160 aagaccgtga tcatggaaaa cctgcgtcgc gtgtacaaga acaccgacac caaggacccc 5220 ctggaacgta acgtggacct gaccttcttc ttccccgtgg gcctgtacct gcccgaggac 5280 cgtggttaca ccaccgtcga gtccaaggtc aagctgaacg acaccgtgcg taacgctctg 5340 cccaccaccg cttacctgct gaacagggac cgtgctgtgc aaaagatcga cttcgtggac 5400 gctctcaaga ccctgtgcca ccccgtgctg cacgagcctg ctccatgcct gcaggctttc 5460 accgagcgtg gtcccccatc cgagcccgct atgcagcgtc tgctggaatg ccgtttccag 5520 caagagccca tgggtggtgc tgctcgtcgt atcccccact tctaccgtgt gcgccgcgag 5580 gtgccccgta ccgtgaacga gatgaagcag gacttcgtgg tcaccgactt ctacaaggtt 5640 ggaaacatca ccctgtacac cgagctgcac cctttcttcg acttcaccca ctgccaagag 5700 aactccgaga ctgtggctct gtgcaccccc cgtatcgtga tcggcaacct gcccgacggc 5760 ctggctcccg gtcccttcca cgagctgagg acctgggaga tcatggaaca catgcgcctg 5820 cgtcccccac ccgactacga ggaaaccctg cgtctgttca agaccaccgt gacctccccc 5880 aactaccccg agctgtgcta cctggtggac gtgctggtgc acggcaacgc tgacgctttc 5940 ctgctgatcc gcgctttcat cgctcgttgc atcgtgaaca tgttccacac ccgtcagctg 6000 ctggtgttcg ctcactccta cgctctggtc accctgatcg ctgagcacct ggctgacggt 6060 gctctgcccc cccagctcct gttccactac cgtaacctgg tggctgtgct gcgcctggtc 6120 acccgtatct ccgctctgcc cggcctgaac aacggccagc tggctgagga acccctgtcc 6180 gcttacgtga acgctctgca cgaccacagg ctgtggcccc ccttcgtgac ccacctccct 6240 cgtaacatgg aaggtgtcca ggtggtggct gatcgtcagc ccctgaaccc cgctaacatc 6300 gaggctcgtc accacggtgt ctccgacgtg ccccgtctgg gtgctatgga cgctgacgag 6360 cccctgttcg tggacgacta ccgtgctacc gacgacgagt ggaccctgca aaaggtgttc 6420 tacctgtgcc tgatccccgc tatgaccaac aaccgtgctt gcggcctggg cctgaacctc 6480 aagactctgc tggtggacct gttctaccgt cccgccttcc tgctcatgcc cgctgctacc 6540 gctgtgtcca cctccggcac cacctccaag gaatccacct ctggtgtcac ccccgaggac 6600 tccgtggctg ctcagcgtca ggctgtgggc gagatgctga ccgagctggt cgaggacgtg 6660 gccaccgacg ctcacacccc tctgctgcag gcttgccgcg agctgttcct ggctgtgcag 6720 ttcgtgggcg agcacgtgaa ggtgctggaa gtgcgtgctc ccctggacca cgctcagagg 6780 cagggactgc ccgacttcat ctcccgtcag catgtgctgt acaacggttg ctgcgtcgtg 6840 accgctccta agaccctgat cgagtactcc ctgcccgtgc ccttccaccg tttctactcc 6900 aaccccacca tctgcgctgc tctgtccgac gacatcaagc gttacgtgac cgagttcccc 6960 cactaccata gacacgatgg tggtttcccc ctgcccaccg ctttcgctca cgagtaccac 7020 aactggctgc gtagcccctt ctcccgttac tccgctacct gccccaacgt gctgcactcc 7080 gtgatgaccc tggctgctat gctgtacaag atctcccccg tgtccctggt gctgcagacc 7140 aaggctcaca tccaccccgg tttcgctctg accgctgtgc gtaccgacac cttcgaggtg 7200 gacatgctgc tgtactccgg caagtcctgc acctccgtca tcatcaacaa ccccatcgtg 7260 accaaggaag agagggacat ctccaccacc taccacgtga cccagaacat caacaccgtg 7320 gacatgggcc tgggttacac ctccaacact tgcgtggcct acgtgaaccg cgtccgcacc 7380 gacatgggtg tccgtgtgca ggacctgttc cgtgtgttcc ccatgaacgt gtaccgccac 7440 gatgaggtgg accgttggat caggcacgct gctggcgtcg agcgtcccca gctgctggac 7500 accgagacta tctccatgct gaccttcggt tccatgtccg agcgcaacgc tgctgctacc 7560 gtgcacggcc agaaggctgt ctgcgagctg atcctgaccc ctgtgactat ggacgtgaac 7620 tacttcaaga tcaccaacaa ccctcgtggt cgtgcttcct gcatgctggg cgtggacccc 7680 tacgacaccg aggctgccac caaggctatc tacgaccacc gcgaggctga cgctcagacc 7740 ttcgctgcta cccacaaccc atgggcttcc caggctggtt gcctgtccga cgtcctgtac 7800 aacacccgtc accgcgagcg tctgggctac aactccaagt tctactcccc ctgcgctcag 7860 tacttcaaca ccgaggaaat catcgctgcc aacaagaccc tcttcaagac catcgacgag 7920 tacctgctgc gcgctaagga ctgcatccgt ggcgacaccg acactcagta cgtgtgcgtc 7980 gagggaaccg agcagctgat cgagaaccct tgccgtctga cccaagaggc tctgcccatc 8040 ctgtccacca ccaccctggc tctgatggaa actaagctga agggtggcgc tggtgctttc 8100 gctacctccg agactcactt cggcaactac gtcgtgggag agatcatccc cctgcagcag 8160 tccatgctgt tcaacagcta agagctcaag cttgtcgaga agtactagag gatcataatc 8220 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 8280 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 8340 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 8400 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 8460 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgt 8520 ggctagcttt gtttaacttt aagaaggaga tacatctaga ccggaatatt aatagatcat 8580 ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac 8640 agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg 8700 cgcggatccc ggtccgaagc gcgcggaatt caaaggccta cgtcgacgcc accatggaat 8760 cccgtggtcg tcgttgcccc gagatgatct ccgtgctggg tcccatctcc ggtcacgtcc 8820 tgaaggctgt gttctcccgt ggcgacaccc ccgtgctgcc ccacgaaact cgtctgctgc 8880 agaccggtat ccacgtgcgt gtgtcccagc cctccctgat cctggtgtcc cagtacaccc 8940 ccgactccac cccttgccac cgcggagaca accagctgca ggtccagcac acctacttca 9000 ccggttccga ggtcgagaac gtgtccgtga acgtgcacaa ccccaccggt cgttccatct 9060 gcccctccca agagcccatg tccatctacg tgtacgctct gcccctgaag atgctgaaca 9120 tcccctccat caacgtgcac cactacccct ccgctgctga gcgcaagcac cgtcacctcc 9180 ccgtggctga cgctgtgatc cacgcttccg gcaagcagat gtggcaggct cgtctgaccg 9240 tgtccggcct ggcttggacc cgtcagcaga accagtggaa ggaacccgac gtgtactaca 9300 cctccgcttt cgtgttcccc accaaggacg tggccctgcg tcacgtcgtg tgcgctcacg 9360 aactcgtgtg ctccatggaa aacacccgtg ctaccaagat gcaagtgatc ggcgaccagt 9420 acgtgaaggt gtacctggaa tccttctgcg aggacgtgcc ctccggcaag ctgttcatgc 9480 acgtgaccct gggttccgac gtggaagagg acctgaccat gacccgtaac ccccagccct 9540 tcatgcgtcc ccacgagcgt aacggtttca ccgtgctgtg ccccaagaac atgatcatca 9600 agcccggcaa gatctcccac atcatgctgg acgtggcctt cacctcccac gagcacttcg 9660 gcctgctgtg ccctaagtcc atccccggcc tgtccatctc cggcaacctg ctgatgaacg 9720 gccagcagat cttcctggaa gtgcaggcta tccgtgaaac cgtcgagctg cgtcagtacg 9780 accctgtggc tgctctgttc ttcttcgaca tcgacctgct gctgcagcgt ggtccccagt 9840 actccgagca ccccaccttc accagccagt accgtatcca gggcaagctg gaataccgtc 9900 acacctggga ccgtcacgac gagggtgctg ctcagggcga cgacgacgtg tggacctccg 9960 gttccgactc cgacgaggaa ctggtcacca ccgagcgcaa gaccccccgt gtgaccggtg 10020 gtggtgctat ggctggtgct tccacctccg ctggtcgcaa gcgcaagtcc gcttcctccg 10080 ctaccgcttg caccgctggt gtcatgaccc gtggtcgcct gaaggctgag tccaccgtgg 10140 ctcccgaaga ggacactgac gaggactccg acaacgagat ccacaacccc gctgtgttca 10200 cctggccccc ctggcaggct ggtatcctgg ctcgtaacct ggtgcccatg gtggctaccg 10260 tgcagggcca gaacctgaag taccaagagt tcttctggga cgccaacgac atctaccgta 10320 tcttcgctga gctggaaggc gtgtggcagc ccgctgctca gcccaagcgt cgtcgtcacc 10380 gtcaggacgc tctgcctggt ccctgtatcg cttccacccc caagaagcac cgcggctaaa 10440 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 10500 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 10560 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 10620 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 10680 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 10740 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccg 10800 gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat 10860 tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat 10920 accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcgc caccatgacc 10980 atggacgagc agcagcccca ggctgtgacc cccgtgtacg tgggcggttt cctggctcgt 11040 tacgaccagt cccccgacga ggctgagctg ctgctgccac gtgacgtggt cgaacactgg 11100 ctgcacgctc agggccaggg acagccttcc ctgtccgtgg ctctgcccct gaacatcaac 11160 cacgacgaca ccgctgtcgt gggtcacgtg gccgctatgc agtccgtgcg tgacggcctg 11220 ttctgcctgg gttgcgtgac ctccccccgt ttcctggaaa tcgtgcgtcg tgcttccgag 11280 aagtccgagc tggtgtcccg tggtcccgtg tccccactgc agcccgacaa ggtggtcgag 11340 ttcctgtccg gttcctacgc tggcctgtcc ctgtcatccc gtcgttgcga cgacgtcgag 11400 gctgctacct ccctgagcgg ctccgagact acccccttca agcacgtggc cctgtgctcc 11460 gtgggtcgta ggcgtggaac cctggctgtg tacggtcgtg accccgagtg ggtcacccag 11520 cgtttccccg acctgaccgc tgctgaccgt gacggactgc gtgctcagtg gcagcgttgc 11580 ggttccaccg ctgtggacgc ttccggcgac cccttccgtt ccgactccta cggcctgctg 11640 ggcaactccg tggacgctct gtacatccgc gagcgtctgc ccaagctgcg ttacgacaag 11700 cagctcgtgg gtgtcaccga gcgcgagtcc tacgtgaagg cttccgtgtc ccccgaggct 11760 gcttgcgaca tcaaggctgc ttccgctgag cgttctggcg acagccgctc ccaggctgct 11820 actcctgctg ctggtgctcg tgtgccctcc agctccccat ccccacctgt cgagcctccc 11880 tcccccgtgc aacctcctgc tctgcctgct tccccctccg tgctgcctgc tgagtccagc 11940 ccctccctgt caccctctga gcctgctgag gctgcctcca tgtcccaccc tctgagcgct 12000 gctgtgactg ctgctaccgc tccccctggt gctactgtgg ctggtgcttc ccccgctgtg 12060 ccttccctgg cttggcctca cgacggtgtc tacctgccca aggacgcttt cttctccctg 12120 ctgggcgctt cccgttccgc tgctcccgtg atgtaccccg gtgctgtggc tgctcccccc 12180 agcgcttcac ctgctcctct gcccctgccc tcctaccccg cttcctacgg tgctcccgtc 12240 gtgggttacg accagctggc tgctcgtcac ttcgctgact acgtggaccc ccactacccc 12300 ggctggggtc gtcgttacga gcccgctcct tccctgcacc catcctaccc tgtgccccct 12360 cctccatcac ccgcttacta ccgtcgtcgt gactcccccg gtggcatgga cgagcctcca 12420 tctggatggg agcgttacga cggttcccac cgtggccagt cccaaaagca gcaccgtcac 12480 ggtggttccg gtggtcacaa caagcgtcgc aaggaagccg ctgctgcatc ctccagctcc 12540 gacgaggacc tgagcttccc cggcgaggct gaacacggtc gtgctcgcaa gcgtctgaag 12600 tcccacgtga actccgacgg aggtagcgga ggccacgctg gttccaacca gcagcagcaa 12660 cagcgctacg acgagctgcg tgacgctatc cacgagctga agcgtgacct gttcgctgct 12720 cgccagtcct ccaccctgct gtctgctgct ctgccagctg ccgcttcttc ctcccctacc 12780 accaccaccg tgtgcacccc tactggcgag ctgacctctg gtggtggcga gactcccacc 12840 gctctgctgt ccggtggtgc taaggtggcc gagcgtgctc aggctggtgt cgtgaacgct 12900 tcctgccgtc tggctaccgc ttccggttcc gaggctgcca ccgctggtcc ctctaccgct 12960 ggttcctcat cctgcccagc ttccgtggtg ctggctgccg ctgctgctca agccgccgct 13020 gcttcacagt cccccccaaa ggatatggtg gacctgaacc gtcgtatctt cgtggctgct 13080 ctgaacaagc tcgagtaata aaagcttgtc gagaagtact agaggatcat aatcagccat 13140 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 13200 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 13260 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 13320 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 13380 cctagaagat ccggctgcta acaaagcccg aaaggaagct gggaatatta atagatcatg 13440 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 13500 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 13560 gcggatccgc caccatggct gctatggaag ctaacatctt ctgcaccttc gaccacaagc 13620 tgtctatcgc tgacgtgggc aagctgacca agctggtggc tgctgtggtg cccatccccc 13680 agcgtctgca cctgatcaag cactaccagc tgggcctgca ccagttcgtg gaccacaccc 13740 gtggttacgt gcgtctgcgt ggcctgctgc gtaacatgac cctgaccctg atgcgtcgtg 13800 tcgagggcaa ccagatcctg ctgcacgtgc ccacccacgg cctgctgtac accgtgctga 13860 acaccggtcc cgtgacctgg gagaagggcg acgctctgtg cgtgctgccc cccctgttcc 13920 acggtcccct ggctcgtgaa aacctgttga ccctgggcca gtgggagctg gtgctgccct 13980 ggatcgtgcc catgcccctg gctctggaaa tcaaccagcg cctgctgatc atgggcctgt 14040 tctccctgga ccgttcctac gaagaagtga aggctgctgt ccagcagctg cagaccatca 14100 ccttccgtga cgctaccttc accatccccg accccgtgat cgaccagcac ctcctgatcg 14160 acatgaagac cgcttgcctg tccatgtcca tggtggctaa cctggcttcc gagctgacca 14220 tgacctacgt ccgcaagctg gctttggagg actcttccat gctgctggtc aagtgccaag 14280 agctgctgat gcgtctggac cgcgagcgtt ccgtgggcga gcctcgtact cccgctcgtc 14340 ctcagcacgt gtcccccgac gacgagatcg ctcgtctgtc cgctctgttc gtgatgctgc 14400 gtcagctgga cgacctgatc cgcgagcagg tcgtgttcac cgtgtgcgac gtgagcccag 14460 acaacaagtc cgctacctgc atcttcaagg gctaaggcgc gccaagcttg tcgagaagta 14520 ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 14580 cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 14640 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 14700 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 14760 ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag 14820 ctgagttggc tgctgctgag tagtgcgcga gcaaaattta agctacaaca aggcacgcgt 14880 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 14940 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 15000 cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt caaaggccta 15060 catggccccc tcccacgtgg acaaggtgaa cacccgcacc tggtccgcct ccatcgtgtt 15120 catggtgctg accttcgtga acgtgtccgt gcacctggtg ctgtccaact tcccccacct 15180 gggctacccc tgcgtgtact accacgtggt ggacttcgag cgcctgaaca tgtccgccta 15240 caacgtgatg cacctgcaca cccccatgct gttcctggac tccgtgcagc tggtgtgcta 15300 cgccgtgttc atgcagctgg tgttcctggc cgtgaccatc tactacctgg tgtgctggat 15360 caagatctcc atgcgcaagg acaagggcat gtccctgaac cagtccaccc gcgacatctc 15420 ctacatgggc gactccctga ccgccttcct gttcatcctg tccatggaca ccttccagct 15480 gttcaccctg accatgtcct tccgcctgcc ctccatgatc gccttcatgg ccgccgtgca 15540 cttcttctgc ctgaccatct tcaacgtgtc catggtgacc cagtaccgct cctacaagcg 15600 ctccctgttc ttcttctccc gcctgcaccc caagctgaag ggcaccgtgc agttccgcac 15660 cctgatcgtg aacctggtgg aggtggccct gggcttcaac accaccgtgg tggccatggc 15720 cctgtgctac ggcttcggca acaacttctt cgtgcgcacc ggccacatgg tgctggccgt 15780 gttcgtggtg tacgccatca tctccatcat ctacttcctg ctgatcgagg ccgtgttctt 15840 ccagtacgtg aaggtgcagt tcggctacca cctgggcgcc ttcttcggcc tgtgcggcct 15900 gatctacccc atcgtgcagt acgacacctt cctgtccaac gagtaccgca ccggcatctc 15960 ctggtccttc ggcatgctgt tcttcatctg ggccatgttc accacctgcc gcgccgtgcg 16020 ctacttccgc ggccgcggct ccggctccgt gaagtaccag gccctggcca ccgcctccgg 16080 cgaggaggtg gccgccctgt cccaccacga ctccctggag tcccgccgcc tgcgcgagga 16140 ggaggacgac gacgacgacg aggacttcga ggacgcctaa aagcttgtcg agaagtacta 16200 gaggatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 16260 acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 16320 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 16380 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 16440 gatctgatca ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg 16500 agttggctgc tgccaccgct gagcaataac tatcataacc cctaggagat ccgaaccaga 16560 taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta gcttacgacg 16620 ctacacccag ttcccatcta ttttgtcact cttccctaaa taatccttaa aaactccatt 16680 tccacccctc ccagttccca actattttgt ccgcccaca 16719 <210> 77 <211> 17186 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 77 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttactgcagc caccaccaca gggagttcag ggtggacagg 2400 ttcacagcac gacggtgctc agggggggtc aggttgccgt aggtggagga ctgcaggctg 2460 aagttacgga tctcagacag gaacagcagg gagtccaggt agtcccacat ggggtcgatg 2520 aaggtgcgct ggaaacgggt ggatggggag gtgggggtgg tcttgttgtt gtcggaagca 2580 gtctcgttct cgacgggcat ggtgtcgttg tagtacaggg aggacatgtc cagggtgccg 2640 tagatggtgt agggagtctc gttacggatc agcacgtgag tgttcttcat gaactcggac 2700 acagcggtac ggttacggtt gggcttgcag aagggctcgt cacggtaacg cagggtggtg 2760 tacacccagg tagccaggtc cttcagctga gtggtcagga tagacttcat gaagttctcg 2820 tcgggacggt aaccgatggt agaggtgggg atacgggtgg gcacgatggg ggagtaggtc 2880 acgttggtgg aaacgttgaa gatggtggag gtgtaggagg agtagggggt agtagtgctg 2940 acgcgggact tcttggagat ggacttcacg ggagcctgct tgcgcttcag cttgcgcatg 3000 gtgttcttca gcttggtgga gttgatgtac ttgggcacac ggaagatgtt acgggacata 3060 gcgttgacca ggtagaagga acgggtgcag ttgcgctgag cgtaacgcag cagcagagca 3120 gccaggccca ggaagtagat agtctgggag tccacgttga ccttggaggg gcccacgtac 3180 agcttggtgt tccaacgggg cacgttgaag aacatggggt tgaaggtggt gaagttgccg 3240 cagttttcct cgccggtgtt gttacgacgg gacacgttca gcatctcgga caggcaggtc 3300 atggagggga tggtgccgca agagggggga cggaaggtga tcttctggcc ggtgtggttg 3360 tactcggagt acacgtactt agcgggcttg cgcagctggg tggtgtggaa gtcgaaccac 3420 aggtgggtga tggagtggtt acggatggga ccagccagga tggagttggg ggggaactgc 3480 ttcatctcga cggtgatgtt gtacagcttc tgctggctgg ggaaggtgaa gaacttgtag 3540 tagtcgccgg tcttggaagc cagctcttgc aggatacgca gcttcagctg gcgttcctct 3600 tccttagcct tctgggactt cacacggaaa cgagccacag cgatcttgca gttgatgaag 3660 ctgaacagca ggaaggtcag ggacatcagg aagaacaggt tgaacacgcc acgcatctcg 3720 cccttgcgac ccatggtggc ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 3780 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 3840 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 3900 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 3960 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 4020 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat ggaaaactgg 4080 tccgctctgg aactgctgcc caaggtcgga atccctaccg acttcctgac ccacgtcaag 4140 acctccgctg gcgaggaaat gttcgaggct ctgaggatct actacggcga cgaccccgag 4200 cgttacaaca tccacttcga ggctatcttc ggcaccttct gcaaccgtct ggaatgggtg 4260 tacttcctga cttccggcct ggctgctgct gctcacgcta tcaagttcca cgacctgaac 4320 aagctgacca ccggcaagat gctgttccac gtgcaagtgc cccgtgtggc ttccggtgct 4380 ggcctgccta cctcccgtca gaccaccatc atggtcacca agtactccga gaagtccccc 4440 atcaccatcc ctttcgagct gtccgctgct tgcctgactt acctgcgtga aaccttcgag 4500 ggcaccatcc tggacaagat cctgaacgtc gaggctatgc acaccgtgct gcgtgctctg 4560 aagaacaccg ctgacgctat ggaacgtggc ctgatccaca gcttcctcca gaccctgctg 4620 aggaaggctc ccccctactt cgtggtgcag accctggtcg agaacgctac cctggctcgt 4680 caggctctga accgtatcca gcgctccaac atcctgcagt ccttcaaggc taagatgctg 4740 gctaccctgt tcctgctgaa ccgtacccgt gaccgtgact acgtgctgaa gttcctgacc 4800 cgtctggctg aggctgctac cgactccatc ctcgacaacc ctactaccta caccacctcc 4860 tccggtgcta agatctccgg tgtcatggtg tccaccgcta acgtgatgca gatcatcatg 4920 tccctgctgt cctcccacat cactaaggaa accgtgtccg ctcccgctac ctacggcaac 4980 ttcgtgctgt cccccgagaa cgctgtgacc gctatctcct accactctat cctggctgac 5040 ttcaactcct acaaggctca cctgacctcc ggccagcccc acctccccaa cgactccctg 5100 agccaggctg gtgctcactc cctgaccccc ctgtccatgg acgtgatccg tctgggcgaa 5160 aagaccgtga tcatggaaaa cctgcgtcgc gtgtacaaga acaccgacac caaggacccc 5220 ctggaacgta acgtggacct gaccttcttc ttccccgtgg gcctgtacct gcccgaggac 5280 cgtggttaca ccaccgtcga gtccaaggtc aagctgaacg acaccgtgcg taacgctctg 5340 cccaccaccg cttacctgct gaacagggac cgtgctgtgc aaaagatcga cttcgtggac 5400 gctctcaaga ccctgtgcca ccccgtgctg cacgagcctg ctccatgcct gcaggctttc 5460 accgagcgtg gtcccccatc cgagcccgct atgcagcgtc tgctggaatg ccgtttccag 5520 caagagccca tgggtggtgc tgctcgtcgt atcccccact tctaccgtgt gcgccgcgag 5580 gtgccccgta ccgtgaacga gatgaagcag gacttcgtgg tcaccgactt ctacaaggtt 5640 ggaaacatca ccctgtacac cgagctgcac cctttcttcg acttcaccca ctgccaagag 5700 aactccgaga ctgtggctct gtgcaccccc cgtatcgtga tcggcaacct gcccgacggc 5760 ctggctcccg gtcccttcca cgagctgagg acctgggaga tcatggaaca catgcgcctg 5820 cgtcccccac ccgactacga ggaaaccctg cgtctgttca agaccaccgt gacctccccc 5880 aactaccccg agctgtgcta cctggtggac gtgctggtgc acggcaacgc tgacgctttc 5940 ctgctgatcc gcgctttcat cgctcgttgc atcgtgaaca tgttccacac ccgtcagctg 6000 ctggtgttcg ctcactccta cgctctggtc accctgatcg ctgagcacct ggctgacggt 6060 gctctgcccc cccagctcct gttccactac cgtaacctgg tggctgtgct gcgcctggtc 6120 acccgtatct ccgctctgcc cggcctgaac aacggccagc tggctgagga acccctgtcc 6180 gcttacgtga acgctctgca cgaccacagg ctgtggcccc ccttcgtgac ccacctccct 6240 cgtaacatgg aaggtgtcca ggtggtggct gatcgtcagc ccctgaaccc cgctaacatc 6300 gaggctcgtc accacggtgt ctccgacgtg ccccgtctgg gtgctatgga cgctgacgag 6360 cccctgttcg tggacgacta ccgtgctacc gacgacgagt ggaccctgca aaaggtgttc 6420 tacctgtgcc tgatccccgc tatgaccaac aaccgtgctt gcggcctggg cctgaacctc 6480 aagactctgc tggtggacct gttctaccgt cccgccttcc tgctcatgcc cgctgctacc 6540 gctgtgtcca cctccggcac cacctccaag gaatccacct ctggtgtcac ccccgaggac 6600 tccgtggctg ctcagcgtca ggctgtgggc gagatgctga ccgagctggt cgaggacgtg 6660 gccaccgacg ctcacacccc tctgctgcag gcttgccgcg agctgttcct ggctgtgcag 6720 ttcgtgggcg agcacgtgaa ggtgctggaa gtgcgtgctc ccctggacca cgctcagagg 6780 cagggactgc ccgacttcat ctcccgtcag catgtgctgt acaacggttg ctgcgtcgtg 6840 accgctccta agaccctgat cgagtactcc ctgcccgtgc ccttccaccg tttctactcc 6900 aaccccacca tctgcgctgc tctgtccgac gacatcaagc gttacgtgac cgagttcccc 6960 cactaccata gacacgatgg tggtttcccc ctgcccaccg ctttcgctca cgagtaccac 7020 aactggctgc gtagcccctt ctcccgttac tccgctacct gccccaacgt gctgcactcc 7080 gtgatgaccc tggctgctat gctgtacaag atctcccccg tgtccctggt gctgcagacc 7140 aaggctcaca tccaccccgg tttcgctctg accgctgtgc gtaccgacac cttcgaggtg 7200 gacatgctgc tgtactccgg caagtcctgc acctccgtca tcatcaacaa ccccatcgtg 7260 accaaggaag agagggacat ctccaccacc taccacgtga cccagaacat caacaccgtg 7320 gacatgggcc tgggttacac ctccaacact tgcgtggcct acgtgaaccg cgtccgcacc 7380 gacatgggtg tccgtgtgca ggacctgttc cgtgtgttcc ccatgaacgt gtaccgccac 7440 gatgaggtgg accgttggat caggcacgct gctggcgtcg agcgtcccca gctgctggac 7500 accgagacta tctccatgct gaccttcggt tccatgtccg agcgcaacgc tgctgctacc 7560 gtgcacggcc agaaggctgt ctgcgagctg atcctgaccc ctgtgactat ggacgtgaac 7620 tacttcaaga tcaccaacaa ccctcgtggt cgtgcttcct gcatgctggg cgtggacccc 7680 tacgacaccg aggctgccac caaggctatc tacgaccacc gcgaggctga cgctcagacc 7740 ttcgctgcta cccacaaccc atgggcttcc caggctggtt gcctgtccga cgtcctgtac 7800 aacacccgtc accgcgagcg tctgggctac aactccaagt tctactcccc ctgcgctcag 7860 tacttcaaca ccgaggaaat catcgctgcc aacaagaccc tcttcaagac catcgacgag 7920 tacctgctgc gcgctaagga ctgcatccgt ggcgacaccg acactcagta cgtgtgcgtc 7980 gagggaaccg agcagctgat cgagaaccct tgccgtctga cccaagaggc tctgcccatc 8040 ctgtccacca ccaccctggc tctgatggaa actaagctga agggtggcgc tggtgctttc 8100 gctacctccg agactcactt cggcaactac gtcgtgggag agatcatccc cctgcagcag 8160 tccatgctgt tcaacagcta agagctcaag cttgtcgaga agtactagag gatcataatc 8220 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 8280 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 8340 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 8400 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 8460 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgt 8520 ggctagcttt gtttaacttt aagaaggaga tacatctaga ccggaatatt aatagatcat 8580 ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac 8640 agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg 8700 cgcggatccc ggtccgaagc gcgcggaatt caaaggccta cgtcgacgcc accatggaat 8760 cccgtggtcg tcgttgcccc gagatgatct ccgtgctggg tcccatctcc ggtcacgtcc 8820 tgaaggctgt gttctcccgt ggcgacaccc ccgtgctgcc ccacgaaact cgtctgctgc 8880 agaccggtat ccacgtgcgt gtgtcccagc cctccctgat cctggtgtcc cagtacaccc 8940 ccgactccac cccttgccac cgcggagaca accagctgca ggtccagcac acctacttca 9000 ccggttccga ggtcgagaac gtgtccgtga acgtgcacaa ccccaccggt cgttccatct 9060 gcccctccca agagcccatg tccatctacg tgtacgctct gcccctgaag atgctgaaca 9120 tcccctccat caacgtgcac cactacccct ccgctgctga gcgcaagcac cgtcacctcc 9180 ccgtggctga cgctgtgatc cacgcttccg gcaagcagat gtggcaggct cgtctgaccg 9240 tgtccggcct ggcttggacc cgtcagcaga accagtggaa ggaacccgac gtgtactaca 9300 cctccgcttt cgtgttcccc accaaggacg tggccctgcg tcacgtcgtg tgcgctcacg 9360 aactcgtgtg ctccatggaa aacacccgtg ctaccaagat gcaagtgatc ggcgaccagt 9420 acgtgaaggt gtacctggaa tccttctgcg aggacgtgcc ctccggcaag ctgttcatgc 9480 acgtgaccct gggttccgac gtggaagagg acctgaccat gacccgtaac ccccagccct 9540 tcatgcgtcc ccacgagcgt aacggtttca ccgtgctgtg ccccaagaac atgatcatca 9600 agcccggcaa gatctcccac atcatgctgg acgtggcctt cacctcccac gagcacttcg 9660 gcctgctgtg ccctaagtcc atccccggcc tgtccatctc cggcaacctg ctgatgaacg 9720 gccagcagat cttcctggaa gtgcaggcta tccgtgaaac cgtcgagctg cgtcagtacg 9780 accctgtggc tgctctgttc ttcttcgaca tcgacctgct gctgcagcgt ggtccccagt 9840 actccgagca ccccaccttc accagccagt accgtatcca gggcaagctg gaataccgtc 9900 acacctggga ccgtcacgac gagggtgctg ctcagggcga cgacgacgtg tggacctccg 9960 gttccgactc cgacgaggaa ctggtcacca ccgagcgcaa gaccccccgt gtgaccggtg 10020 gtggtgctat ggctggtgct tccacctccg ctggtcgcaa gcgcaagtcc gcttcctccg 10080 ctaccgcttg caccgctggt gtcatgaccc gtggtcgcct gaaggctgag tccaccgtgg 10140 ctcccgaaga ggacactgac gaggactccg acaacgagat ccacaacccc gctgtgttca 10200 cctggccccc ctggcaggct ggtatcctgg ctcgtaacct ggtgcccatg gtggctaccg 10260 tgcagggcca gaacctgaag taccaagagt tcttctggga cgccaacgac atctaccgta 10320 tcttcgctga gctggaaggc gtgtggcagc ccgctgctca gcccaagcgt cgtcgtcacc 10380 gtcaggacgc tctgcctggt ccctgtatcg cttccacccc caagaagcac cgcggctaaa 10440 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 10500 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 10560 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 10620 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 10680 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 10740 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccg 10800 gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat 10860 tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat 10920 accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcgc caccatgacc 10980 atggacgagc agcagcccca ggctgtgacc cccgtgtacg tgggcggttt cctggctcgt 11040 tacgaccagt cccccgacga ggctgagctg ctgctgccac gtgacgtggt cgaacactgg 11100 ctgcacgctc agggccaggg acagccttcc ctgtccgtgg ctctgcccct gaacatcaac 11160 cacgacgaca ccgctgtcgt gggtcacgtg gccgctatgc agtccgtgcg tgacggcctg 11220 ttctgcctgg gttgcgtgac ctccccccgt ttcctggaaa tcgtgcgtcg tgcttccgag 11280 aagtccgagc tggtgtcccg tggtcccgtg tccccactgc agcccgacaa ggtggtcgag 11340 ttcctgtccg gttcctacgc tggcctgtcc ctgtcatccc gtcgttgcga cgacgtcgag 11400 gctgctacct ccctgagcgg ctccgagact acccccttca agcacgtggc cctgtgctcc 11460 gtgggtcgta ggcgtggaac cctggctgtg tacggtcgtg accccgagtg ggtcacccag 11520 cgtttccccg acctgaccgc tgctgaccgt gacggactgc gtgctcagtg gcagcgttgc 11580 ggttccaccg ctgtggacgc ttccggcgac cccttccgtt ccgactccta cggcctgctg 11640 ggcaactccg tggacgctct gtacatccgc gagcgtctgc ccaagctgcg ttacgacaag 11700 cagctcgtgg gtgtcaccga gcgcgagtcc tacgtgaagg cttccgtgtc ccccgaggct 11760 gcttgcgaca tcaaggctgc ttccgctgag cgttctggcg acagccgctc ccaggctgct 11820 actcctgctg ctggtgctcg tgtgccctcc agctccccat ccccacctgt cgagcctccc 11880 tcccccgtgc aacctcctgc tctgcctgct tccccctccg tgctgcctgc tgagtccagc 11940 ccctccctgt caccctctga gcctgctgag gctgcctcca tgtcccaccc tctgagcgct 12000 gctgtgactg ctgctaccgc tccccctggt gctactgtgg ctggtgcttc ccccgctgtg 12060 ccttccctgg cttggcctca cgacggtgtc tacctgccca aggacgcttt cttctccctg 12120 ctgggcgctt cccgttccgc tgctcccgtg atgtaccccg gtgctgtggc tgctcccccc 12180 agcgcttcac ctgctcctct gcccctgccc tcctaccccg cttcctacgg tgctcccgtc 12240 gtgggttacg accagctggc tgctcgtcac ttcgctgact acgtggaccc ccactacccc 12300 ggctggggtc gtcgttacga gcccgctcct tccctgcacc catcctaccc tgtgccccct 12360 cctccatcac ccgcttacta ccgtcgtcgt gactcccccg gtggcatgga cgagcctcca 12420 tctggatggg agcgttacga cggttcccac cgtggccagt cccaaaagca gcaccgtcac 12480 ggtggttccg gtggtcacaa caagcgtcgc aaggaagccg ctgctgcatc ctccagctcc 12540 gacgaggacc tgagcttccc cggcgaggct gaacacggtc gtgctcgcaa gcgtctgaag 12600 tcccacgtga actccgacgg aggtagcgga ggccacgctg gttccaacca gcagcagcaa 12660 cagcgctacg acgagctgcg tgacgctatc cacgagctga agcgtgacct gttcgctgct 12720 cgccagtcct ccaccctgct gtctgctgct ctgccagctg ccgcttcttc ctcccctacc 12780 accaccaccg tgtgcacccc tactggcgag ctgacctctg gtggtggcga gactcccacc 12840 gctctgctgt ccggtggtgc taaggtggcc gagcgtgctc aggctggtgt cgtgaacgct 12900 tcctgccgtc tggctaccgc ttccggttcc gaggctgcca ccgctggtcc ctctaccgct 12960 ggttcctcat cctgcccagc ttccgtggtg ctggctgccg ctgctgctca agccgccgct 13020 gcttcacagt cccccccaaa ggatatggtg gacctgaacc gtcgtatctt cgtggctgct 13080 ctgaacaagc tcgagtaata aaagcttgtc gagaagtact agaggatcat aatcagccat 13140 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 13200 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 13260 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 13320 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 13380 cctagaagat ccggctgcta acaaagcccg aaaggaagct gggaatatta atagatcatg 13440 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 13500 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 13560 gcggatccgc caccatggct gctatggaag ctaacatctt ctgcaccttc gaccacaagc 13620 tgtctatcgc tgacgtgggc aagctgacca agctggtggc tgctgtggtg cccatccccc 13680 agcgtctgca cctgatcaag cactaccagc tgggcctgca ccagttcgtg gaccacaccc 13740 gtggttacgt gcgtctgcgt ggcctgctgc gtaacatgac cctgaccctg atgcgtcgtg 13800 tcgagggcaa ccagatcctg ctgcacgtgc ccacccacgg cctgctgtac accgtgctga 13860 acaccggtcc cgtgacctgg gagaagggcg acgctctgtg cgtgctgccc cccctgttcc 13920 acggtcccct ggctcgtgaa aacctgttga ccctgggcca gtgggagctg gtgctgccct 13980 ggatcgtgcc catgcccctg gctctggaaa tcaaccagcg cctgctgatc atgggcctgt 14040 tctccctgga ccgttcctac gaagaagtga aggctgctgt ccagcagctg cagaccatca 14100 ccttccgtga cgctaccttc accatccccg accccgtgat cgaccagcac ctcctgatcg 14160 acatgaagac cgcttgcctg tccatgtcca tggtggctaa cctggcttcc gagctgacca 14220 tgacctacgt ccgcaagctg gctttggagg actcttccat gctgctggtc aagtgccaag 14280 agctgctgat gcgtctggac cgcgagcgtt ccgtgggcga gcctcgtact cccgctcgtc 14340 ctcagcacgt gtcccccgac gacgagatcg ctcgtctgtc cgctctgttc gtgatgctgc 14400 gtcagctgga cgacctgatc cgcgagcagg tcgtgttcac cgtgtgcgac gtgagcccag 14460 acaacaagtc cgctacctgc atcttcaagg gccagctgtt gaattttgac cttcttaagc 14520 ttgcgggaga cgtcgagtcc aaccctgggc ccatggcccc ctcccacgtg gacaaggtga 14580 acacccgcac ctggtccgcc tccatcgtgt tcatggtgct gaccttcgtg aacgtgtccg 14640 tgcacctggt gctgtccaac ttcccccacc tgggctaccc ctgcgtgtac taccacgtgg 14700 tggacttcga gcgcctgaac atgtccgcct acaacgtgat gcacctgcac acccccatgc 14760 tgttcctgga ctccgtgcag ctggtgtgct acgccgtgtt catgcagctg gtgttcctgg 14820 ccgtgaccat ctactacctg gtgtgctgga tcaagatctc catgcgcaag gacaagggca 14880 tgtccctgaa ccagtccacc cgcgacatct cctacatggg cgactccctg accgccttcc 14940 tgttcatcct gtccatggac accttccagc tgttcaccct gaccatgtcc ttccgcctgc 15000 cctccatgat cgccttcatg gccgccgtgc acttcttctg cctgaccatc ttcaacgtgt 15060 ccatggtgac ccagtaccgc tcctacaagc gctccctgtt cttcttctcc cgcctgcacc 15120 ccaagctgaa gggcaccgtg cagttccgca ccctgatcgt gaacctggtg gaggtggccc 15180 tgggcttcaa caccaccgtg gtggccatgg ccctgtgcta cggcttcggc aacaacttct 15240 tcgtgcgcac cggccacatg gtgctggccg tgttcgtggt gtacgccatc atctccatca 15300 tctacttcct gctgatcgag gccgtgttct tccagtacgt gaaggtgcag ttcggctacc 15360 acctgggcgc cttcttcggc ctgtgcggcc tgatctaccc catcgtgcag tacgacacct 15420 tcctgtccaa cgagtaccgc accggcatct cctggtcctt cggcatgctg ttcttcatct 15480 gggccatgtt caccacctgc cgcgccgtgc gctacttccg cggccgcggc tccggctccg 15540 tgaagtacca ggccctggcc accgcctccg gcgaggaggt ggccgccctg tcccaccacg 15600 actccctgga gtcccgccgc ctgcgcgagg aggaggacga cgacgacgac gaggacttcg 15660 aggacgccta agagctcaag cttgtcgaga agtactagag gatcataatc agccatacca 15720 catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac 15780 ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat 15840 aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg 15900 gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta 15960 gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgt ggctagcttt 16020 gtttaacttt aagaaggaga tacatctaga aatattaata gatcatggag ataattaaaa 16080 tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa 16140 aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg gatcccggtc 16200 cgaagcgcgc ggaattcaaa ggcctacgcc accatggagt ggaacacact agtactaggt 16260 cttttggttt tatcggtagc ggcaagttcc aaccatacgt cgactgctag cacaccgagt 16320 ccctctagct ctactcacac ctcaacgacc gtgaaggcaa cgactactgc gacaactagt 16380 acaactacgg tgacaagtac gacttcatca acgactagta ccaaacccgg ttccaccact 16440 cacgacccca atgtgatgag accacatgct cacaatgatt tttacaaggc gcattgtaca 16500 tcgcatatgt atgaactttc tctgtccagc tttgcggcct ggtggactat gcttaatgct 16560 ctcattctca tgggagcttt ttgtatcgta ctacgacatt gctgtttcca gaactttact 16620 gcaaccacca ccaaaggcta ttgataaaag cttgtcgaga agtactagag gatcataatc 16680 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 16740 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 16800 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 16860 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 16920 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgc 16980 caccgctgag caataactat cataacccct aggagatccg aaccagataa gtgaaatcta 17040 gttccaaact attttgtcat ttttaatttt cgtattagct tacgacgcta cacccagttc 17100 ccatctattt tgtcactctt ccctaaataa tccttaaaaa ctccatttcc acccctccca 17160 gttcccaact attttgtccg cccaca 17186 <210> 78 <211> 9594 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 78 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaaat attaatagat 7200 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 7260 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 7320 gggcgcggat ccgccaccat ggctgctatg gaagctaaca tcttctgcac cttcgaccac 7380 aagctgtcta tcgctgacgt gggcaagctg accaagctgg tggctgctgt ggtgcccatc 7440 ccccagcgtc tgcacctgat caagcactac cagctgggcc tgcaccagtt cgtggaccac 7500 acccgtggtt acgtgcgtct gcgtggcctg ctgcgtaaca tgaccctgac cctgatgcgt 7560 cgtgtcgagg gcaaccagat cctgctgcac gtgcccaccc acggcctgct gtacaccgtg 7620 ctgaacaccg gtcccgtgac ctgggagaag ggcgacgctc tgtgcgtgct gccccccctg 7680 ttccacggtc ccctggctcg tgaaaacctg ttgaccctgg gccagtggga gctggtgctg 7740 ccctggatcg tgcccatgcc cctggctctg gaaatcaacc agcgcctgct gatcatgggc 7800 ctgttctccc tggaccgttc ctacgaagaa gtgaaggctg ctgtccagca gctgcagacc 7860 atcaccttcc gtgacgctac cttcaccatc cccgaccccg tgatcgacca gcacctcctg 7920 atcgacatga agaccgcttg cctgtccatg tccatggtgg ctaacctggc ttccgagctg 7980 accatgacct acgtccgcaa gctggctttg gaggactctt ccatgctgct ggtcaagtgc 8040 caagagctgc tgatgcgtct ggaccgcgag cgttccgtgg gcgagcctcg tactcccgct 8100 cgtcctcagc acgtgtcccc cgacgacgag atcgctcgtc tgtccgctct gttcgtgatg 8160 ctgcgtcagc tggacgacct gatccgcgag caggtcgtgt tcaccgtgtg cgacgtgagc 8220 ccagacaaca agtccgctac ctgcatcttc aagggctaag gcgcgccaag cttgtcgaga 8280 agtactagag gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa 8340 acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact 8400 tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 8460 aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc 8520 atgtctggat ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag 8580 gaagctgagt tggctgctgg gtgcctaatg agtgagctaa ctcacattaa ttgcccggaa 8640 tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt 8700 actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc 8760 gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcaaagg cctacgtcga 8820 cgccaccatg tccaacaccg ctcccggtcc caccgtggct aacaagcgtg acgagaagca 8880 ccgtcacgtg gtcaacgtgg tgctcgagct gcccaccgag atctccgagg ctacccaccc 8940 cgtgctggct accatgctgt ccaagtacac ccgtatgtcc tccctgttca acgacaagtg 9000 cgctttcaag ctggacctgc tgcgtatggt ggctgtgtcc cgtacccgtc gctaaaagct 9060 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 9120 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 9180 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 9240 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 9300 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 9360 cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca taacccctag 9420 gagatccgaa ccagataagt gaaatctagt tccaaactat tttgtcattt ttaattttcg 9480 tattagctta cgacgctaca cccagttccc atctattttg tcactcttcc ctaaataatc 9540 cttaaaaact ccatttccac ccctcccagt tcccaactat tttgtccgcc caca 9594 <210> 79 <211> 11261 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 79 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaaat attaatagat 7200 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 7260 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 7320 gggcgcggat ccgccaccat ggctgctatg gaagctaaca tcttctgcac cttcgaccac 7380 aagctgtcta tcgctgacgt gggcaagctg accaagctgg tggctgctgt ggtgcccatc 7440 ccccagcgtc tgcacctgat caagcactac cagctgggcc tgcaccagtt cgtggaccac 7500 acccgtggtt acgtgcgtct gcgtggcctg ctgcgtaaca tgaccctgac cctgatgcgt 7560 cgtgtcgagg gcaaccagat cctgctgcac gtgcccaccc acggcctgct gtacaccgtg 7620 ctgaacaccg gtcccgtgac ctgggagaag ggcgacgctc tgtgcgtgct gccccccctg 7680 ttccacggtc ccctggctcg tgaaaacctg ttgaccctgg gccagtggga gctggtgctg 7740 ccctggatcg tgcccatgcc cctggctctg gaaatcaacc agcgcctgct gatcatgggc 7800 ctgttctccc tggaccgttc ctacgaagaa gtgaaggctg ctgtccagca gctgcagacc 7860 atcaccttcc gtgacgctac cttcaccatc cccgaccccg tgatcgacca gcacctcctg 7920 atcgacatga agaccgcttg cctgtccatg tccatggtgg ctaacctggc ttccgagctg 7980 accatgacct acgtccgcaa gctggctttg gaggactctt ccatgctgct ggtcaagtgc 8040 caagagctgc tgatgcgtct ggaccgcgag cgttccgtgg gcgagcctcg tactcccgct 8100 cgtcctcagc acgtgtcccc cgacgacgag atcgctcgtc tgtccgctct gttcgtgatg 8160 ctgcgtcagc tggacgacct gatccgcgag caggtcgtgt tcaccgtgtg cgacgtgagc 8220 ccagacaaca agtccgctac ctgcatcttc aagggctaag gcgcgccaag cttgtcgaga 8280 agtactagag gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa 8340 acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact 8400 tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 8460 aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc 8520 atgtctggat ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag 8580 gaagctgagt tggctgctgg gtgcctaatg agtgagctaa ctcacattaa ttgcccggaa 8640 tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt 8700 actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc 8760 gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcaaagg cctacgtcga 8820 cgccaccatg tccaacaccg ctcccggtcc caccgtggct aacaagcgtg acgagaagca 8880 ccgtcacgtg gtcaacgtgg tgctcgagct gcccaccgag atctccgagg ctacccaccc 8940 cgtgctggct accatgctgt ccaagtacac ccgtatgtcc tccctgttca acgacaagtg 9000 cgctttcaag ctggacctgc tgcgtatggt ggctgtgtcc cgtacccgtc gctaaaagct 9060 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 9120 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 9180 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 9240 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 9300 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 9360 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 9420 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 9480 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 9540 ttcataccgt cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcaaaggcc 9600 tacatggccc cctcccacgt ggacaaggtg aacacccgca cctggtccgc ctccatcgtg 9660 ttcatggtgc tgaccttcgt gaacgtgtcc gtgcacctgg tgctgtccaa cttcccccac 9720 ctgggctacc cctgcgtgta ctaccacgtg gtggacttcg agcgcctgaa catgtccgcc 9780 tacaacgtga tgcacctgca cacccccatg ctgttcctgg actccgtgca gctggtgtgc 9840 tacgccgtgt tcatgcagct ggtgttcctg gccgtgacca tctactacct ggtgtgctgg 9900 atcaagatct ccatgcgcaa ggacaagggc atgtccctga accagtccac ccgcgacatc 9960 tcctacatgg gcgactccct gaccgccttc ctgttcatcc tgtccatgga caccttccag 10020 ctgttcaccc tgaccatgtc cttccgcctg ccctccatga tcgccttcat ggccgccgtg 10080 cacttcttct gcctgaccat cttcaacgtg tccatggtga cccagtaccg ctcctacaag 10140 cgctccctgt tcttcttctc ccgcctgcac cccaagctga agggcaccgt gcagttccgc 10200 accctgatcg tgaacctggt ggaggtggcc ctgggcttca acaccaccgt ggtggccatg 10260 gccctgtgct acggcttcgg caacaacttc ttcgtgcgca ccggccacat ggtgctggcc 10320 gtgttcgtgg tgtacgccat catctccatc atctacttcc tgctgatcga ggccgtgttc 10380 ttccagtacg tgaaggtgca gttcggctac cacctgggcg ccttcttcgg cctgtgcggc 10440 ctgatctacc ccatcgtgca gtacgacacc ttcctgtcca acgagtaccg caccggcatc 10500 tcctggtcct tcggcatgct gttcttcatc tgggccatgt tcaccacctg ccgcgccgtg 10560 cgctacttcc gcggccgcgg ctccggctcc gtgaagtacc aggccctggc caccgcctcc 10620 ggcgaggagg tggccgccct gtcccaccac gactccctgg agtcccgccg cctgcgcgag 10680 gaggaggacg acgacgacga cgaggacttc gaggacgcct aaaagcttgt cgagaagtac 10740 tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc 10800 ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 10860 attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 10920 tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 10980 tggatctgat cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc 11040 tgagttggct gctgccaccg ctgagcaata actatcataa cccctaggag atccgaacca 11100 gataagtgaa atctagttcc aaactatttt gtcattttta attttcgtat tagcttacga 11160 cgctacaccc agttcccatc tattttgtca ctcttcccta aataatcctt aaaaactcca 11220 tttccacccc tcccagttcc caactatttt gtccgcccac a 11261 <210> 80 <211> 11840 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 80 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaaat attaatagat 7200 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 7260 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 7320 gggcgcggat ccgccaccat ggctgctatg gaagctaaca tcttctgcac cttcgaccac 7380 aagctgtcta tcgctgacgt gggcaagctg accaagctgg tggctgctgt ggtgcccatc 7440 ccccagcgtc tgcacctgat caagcactac cagctgggcc tgcaccagtt cgtggaccac 7500 acccgtggtt acgtgcgtct gcgtggcctg ctgcgtaaca tgaccctgac cctgatgcgt 7560 cgtgtcgagg gcaaccagat cctgctgcac gtgcccaccc acggcctgct gtacaccgtg 7620 ctgaacaccg gtcccgtgac ctgggagaag ggcgacgctc tgtgcgtgct gccccccctg 7680 ttccacggtc ccctggctcg tgaaaacctg ttgaccctgg gccagtggga gctggtgctg 7740 ccctggatcg tgcccatgcc cctggctctg gaaatcaacc agcgcctgct gatcatgggc 7800 ctgttctccc tggaccgttc ctacgaagaa gtgaaggctg ctgtccagca gctgcagacc 7860 atcaccttcc gtgacgctac cttcaccatc cccgaccccg tgatcgacca gcacctcctg 7920 atcgacatga agaccgcttg cctgtccatg tccatggtgg ctaacctggc ttccgagctg 7980 accatgacct acgtccgcaa gctggctttg gaggactctt ccatgctgct ggtcaagtgc 8040 caagagctgc tgatgcgtct ggaccgcgag cgttccgtgg gcgagcctcg tactcccgct 8100 cgtcctcagc acgtgtcccc cgacgacgag atcgctcgtc tgtccgctct gttcgtgatg 8160 ctgcgtcagc tggacgacct gatccgcgag caggtcgtgt tcaccgtgtg cgacgtgagc 8220 ccagacaaca agtccgctac ctgcatcttc aagggctaag gcgcgccaag cttgtcgaga 8280 agtactagag gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa 8340 acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact 8400 tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 8460 aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc 8520 atgtctggat ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag 8580 gaagctgagt tggctgctgg gtgcctaatg agtgagctaa ctcacattaa ttgcccggaa 8640 tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt 8700 actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc 8760 gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcaaagg cctacgtcga 8820 cgccaccatg tccaacaccg ctcccggtcc caccgtggct aacaagcgtg acgagaagca 8880 ccgtcacgtg gtcaacgtgg tgctcgagct gcccaccgag atctccgagg ctacccaccc 8940 cgtgctggct accatgctgt ccaagtacac ccgtatgtcc tccctgttca acgacaagtg 9000 cgctttcaag ctggacctgc tgcgtatggt ggctgtgtcc cgtacccgtc gctaaaagct 9060 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 9120 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 9180 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 9240 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 9300 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 9360 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 9420 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 9480 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 9540 ttcataccgt cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcaaaggcc 9600 tacgtcgacg ccaccatgga atcccgtggt cgtcgttgcc ccgagatgat ctccgtgctg 9660 ggtcccatct ccggtcacgt cctgaaggct gtgttctccc gtggcgacac ccccgtgctg 9720 ccccacgaaa ctcgtctgct gcagaccggt atccacgtgc gtgtgtccca gccctccctg 9780 atcctggtgt cccagtacac ccccgactcc accccttgcc accgcggaga caaccagctg 9840 caggtccagc acacctactt caccggttcc gaggtcgaga acgtgtccgt gaacgtgcac 9900 aaccccaccg gtcgttccat ctgcccctcc caagagccca tgtccatcta cgtgtacgct 9960 ctgcccctga agatgctgaa catcccctcc atcaacgtgc accactaccc ctccgctgct 10020 gagcgcaagc accgtcacct ccccgtggct gacgctgtga tccacgcttc cggcaagcag 10080 atgtggcagg ctcgtctgac cgtgtccggc ctggcttgga cccgtcagca gaaccagtgg 10140 aaggaacccg acgtgtacta cacctccgct ttcgtgttcc ccaccaagga cgtggccctg 10200 cgtcacgtcg tgtgcgctca cgaactcgtg tgctccatgg aaaacacccg tgctaccaag 10260 atgcaagtga tcggcgacca gtacgtgaag gtgtacctgg aatccttctg cgaggacgtg 10320 ccctccggca agctgttcat gcacgtgacc ctgggttccg acgtggaaga ggacctgacc 10380 atgacccgta acccccagcc cttcatgcgt ccccacgagc gtaacggttt caccgtgctg 10440 tgccccaaga acatgatcat caagcccggc aagatctccc acatcatgct ggacgtggcc 10500 ttcacctccc acgagcactt cggcctgctg tgccctaagt ccatccccgg cctgtccatc 10560 tccggcaacc tgctgatgaa cggccagcag atcttcctgg aagtgcaggc tatccgtgaa 10620 accgtcgagc tgcgtcagta cgaccctgtg gctgctctgt tcttcttcga catcgacctg 10680 ctgctgcagc gtggtcccca gtactccgag caccccacct tcaccagcca gtaccgtatc 10740 cagggcaagc tggaataccg tcacacctgg gaccgtcacg acgagggtgc tgctcagggc 10800 gacgacgacg tgtggacctc cggttccgac tccgacgagg aactggtcac caccgagcgc 10860 aagacccccc gtgtgaccgg tggtggtgct atggctggtg cttccacctc cgctggtcgc 10920 aagcgcaagt ccgcttcctc cgctaccgct tgcaccgctg gtgtcatgac ccgtggtcgc 10980 ctgaaggctg agtccaccgt ggctcccgaa gaggacactg acgaggactc cgacaacgag 11040 atccacaacc ccgctgtgtt cacctggccc ccctggcagg ctggtatcct ggctcgtaac 11100 ctggtgccca tggtggctac cgtgcagggc cagaacctga agtaccaaga gttcttctgg 11160 gacgccaacg acatctaccg tatcttcgct gagctggaag gcgtgtggca gcccgctgct 11220 cagcccaagc gtcgtcgtca ccgtcaggac gctctgcctg gtccctgtat cgcttccacc 11280 cccaagaagc accgcggcta aaagcttgtc gagaagtact agaggatcat aatcagccat 11340 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 11400 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 11460 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 11520 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 11580 cctagaagat ccggctgcta acaaagcccg aaaggaagct gagttggctg ctgccaccgc 11640 tgagcaataa ctatcataac ccctaggaga tccgaaccag ataagtgaaa tctagttcca 11700 aactattttg tcatttttaa ttttcgtatt agcttacgac gctacaccca gttcccatct 11760 attttgtcac tcttccctaa ataatcctta aaaactccat ttccacccct cccagttccc 11820 aactattttg tccgcccaca 11840 <210> 81 <211> 13439 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 81 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaaat attaatagat 7200 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 7260 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 7320 gggcgcggat ccgccaccat ggctgctatg gaagctaaca tcttctgcac cttcgaccac 7380 aagctgtcta tcgctgacgt gggcaagctg accaagctgg tggctgctgt ggtgcccatc 7440 ccccagcgtc tgcacctgat caagcactac cagctgggcc tgcaccagtt cgtggaccac 7500 acccgtggtt acgtgcgtct gcgtggcctg ctgcgtaaca tgaccctgac cctgatgcgt 7560 cgtgtcgagg gcaaccagat cctgctgcac gtgcccaccc acggcctgct gtacaccgtg 7620 ctgaacaccg gtcccgtgac ctgggagaag ggcgacgctc tgtgcgtgct gccccccctg 7680 ttccacggtc ccctggctcg tgaaaacctg ttgaccctgg gccagtggga gctggtgctg 7740 ccctggatcg tgcccatgcc cctggctctg gaaatcaacc agcgcctgct gatcatgggc 7800 ctgttctccc tggaccgttc ctacgaagaa gtgaaggctg ctgtccagca gctgcagacc 7860 atcaccttcc gtgacgctac cttcaccatc cccgaccccg tgatcgacca gcacctcctg 7920 atcgacatga agaccgcttg cctgtccatg tccatggtgg ctaacctggc ttccgagctg 7980 accatgacct acgtccgcaa gctggctttg gaggactctt ccatgctgct ggtcaagtgc 8040 caagagctgc tgatgcgtct ggaccgcgag cgttccgtgg gcgagcctcg tactcccgct 8100 cgtcctcagc acgtgtcccc cgacgacgag atcgctcgtc tgtccgctct gttcgtgatg 8160 ctgcgtcagc tggacgacct gatccgcgag caggtcgtgt tcaccgtgtg cgacgtgagc 8220 ccagacaaca agtccgctac ctgcatcttc aagggctaag gcgcgccaag cttgtcgaga 8280 agtactagag gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa 8340 acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact 8400 tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 8460 aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc 8520 atgtctggat ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag 8580 gaagctgagt tggctgctgg gtgcctaatg agtgagctaa ctcacattaa ttgcccggaa 8640 tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt 8700 actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc 8760 gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcaaagg cctacgtcga 8820 cgccaccatg tccaacaccg ctcccggtcc caccgtggct aacaagcgtg acgagaagca 8880 ccgtcacgtg gtcaacgtgg tgctcgagct gcccaccgag atctccgagg ctacccaccc 8940 cgtgctggct accatgctgt ccaagtacac ccgtatgtcc tccctgttca acgacaagtg 9000 cgctttcaag ctggacctgc tgcgtatggt ggctgtgtcc cgtacccgtc gctaaaagct 9060 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 9120 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 9180 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 9240 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 9300 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 9360 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 9420 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 9480 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 9540 ttcataccgt cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcaaaggcc 9600 tacgtcgacg ccaccatgga atcccgtggt cgtcgttgcc ccgagatgat ctccgtgctg 9660 ggtcccatct ccggtcacgt cctgaaggct gtgttctccc gtggcgacac ccccgtgctg 9720 ccccacgaaa ctcgtctgct gcagaccggt atccacgtgc gtgtgtccca gccctccctg 9780 atcctggtgt cccagtacac ccccgactcc accccttgcc accgcggaga caaccagctg 9840 caggtccagc acacctactt caccggttcc gaggtcgaga acgtgtccgt gaacgtgcac 9900 aaccccaccg gtcgttccat ctgcccctcc caagagccca tgtccatcta cgtgtacgct 9960 ctgcccctga agatgctgaa catcccctcc atcaacgtgc accactaccc ctccgctgct 10020 gagcgcaagc accgtcacct ccccgtggct gacgctgtga tccacgcttc cggcaagcag 10080 atgtggcagg ctcgtctgac cgtgtccggc ctggcttgga cccgtcagca gaaccagtgg 10140 aaggaacccg acgtgtacta cacctccgct ttcgtgttcc ccaccaagga cgtggccctg 10200 cgtcacgtcg tgtgcgctca cgaactcgtg tgctccatgg aaaacacccg tgctaccaag 10260 atgcaagtga tcggcgacca gtacgtgaag gtgtacctgg aatccttctg cgaggacgtg 10320 ccctccggca agctgttcat gcacgtgacc ctgggttccg acgtggaaga ggacctgacc 10380 atgacccgta acccccagcc cttcatgcgt ccccacgagc gtaacggttt caccgtgctg 10440 tgccccaaga acatgatcat caagcccggc aagatctccc acatcatgct ggacgtggcc 10500 ttcacctccc acgagcactt cggcctgctg tgccctaagt ccatccccgg cctgtccatc 10560 tccggcaacc tgctgatgaa cggccagcag atcttcctgg aagtgcaggc tatccgtgaa 10620 accgtcgagc tgcgtcagta cgaccctgtg gctgctctgt tcttcttcga catcgacctg 10680 ctgctgcagc gtggtcccca gtactccgag caccccacct tcaccagcca gtaccgtatc 10740 cagggcaagc tggaataccg tcacacctgg gaccgtcacg acgagggtgc tgctcagggc 10800 gacgacgacg tgtggacctc cggttccgac tccgacgagg aactggtcac caccgagcgc 10860 aagacccccc gtgtgaccgg tggtggtgct atggctggtg cttccacctc cgctggtcgc 10920 aagcgcaagt ccgcttcctc cgctaccgct tgcaccgctg gtgtcatgac ccgtggtcgc 10980 ctgaaggctg agtccaccgt ggctcccgaa gaggacactg acgaggactc cgacaacgag 11040 atccacaacc ccgctgtgtt cacctggccc ccctggcagg ctggtatcct ggctcgtaac 11100 ctggtgccca tggtggctac cgtgcagggc cagaacctga agtaccaaga gttcttctgg 11160 gacgccaacg acatctaccg tatcttcgct gagctggaag gcgtgtggca gcccgctgct 11220 cagcccaagc gtcgtcgtca ccgtcaggac gctctgcctg gtccctgtat cgcttccacc 11280 cccaagaagc accgcggcta aaagcttgtc gagaagtact agaggatcat aatcagccat 11340 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 11400 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 11460 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 11520 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 11580 cctagaagat ccggctgcta acaaagcccg aaaggaagct gggaatatta atagatcaat 11640 ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac 11700 agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg 11760 cgcggatccg ccaccatggc cccctcccac gtggacaagg tgaacacccg cacctggtcc 11820 gcctccatcg tgttcatggt gctgaccttc gtgaacgtgt ccgtgcacct ggtgctgtcc 11880 aacttccccc acctgggcta cccctgcgtg tactaccacg tggtggactt cgagcgcctg 11940 aacatgtccg cctacaacgt gatgcacctg cacaccccca tgctgttcct ggactccgtg 12000 cagctggtgt gctacgccgt gttcatgcag ctggtgttcc tggccgtgac catctactac 12060 ctggtgtgct ggatcaagat ctccatgcgc aaggacaagg gcatgtccct gaaccagtcc 12120 acccgcgaca tctcctacat gggcgactcc ctgaccgcct tcctgttcat cctgtccatg 12180 gacaccttcc agctgttcac cctgaccatg tccttccgcc tgccctccat gatcgccttc 12240 atggccgccg tgcacttctt ctgcctgacc atcttcaacg tgtccatggt gacccagtac 12300 cgctcctaca agcgctccct gttcttcttc tcccgcctgc accccaagct gaagggcacc 12360 gtgcagttcc gcaccctgat cgtgaacctg gtggaggtgg ccctgggctt caacaccacc 12420 gtggtggcca tggccctgtg ctacggcttc ggcaacaact tcttcgtgcg caccggccac 12480 atggtgctgg ccgtgttcgt ggtgtacgcc atcatctcca tcatctactt cctgctgatc 12540 gaggccgtgt tcttccagta cgtgaaggtg cagttcggct accacctggg cgccttcttc 12600 ggcctgtgcg gcctgatcta ccccatcgtg cagtacgaca ccttcctgtc caacgagtac 12660 cgcaccggca tctcctggtc cttcggcatg ctgttcttca tctgggccat gttcaccacc 12720 tgccgcgccg tgcgctactt ccgcggccgc ggctccggct ccgtgaagta ccaggccctg 12780 gccaccgcct ccggcgagga ggtggccgcc ctgtcccacc acgactccct ggagtcccgc 12840 cgcctgcgcg aggaggagga cgacgacgac gacgaggact tcgaggacgc ctaagagctc 12900 aagcttgtcg agaagtacta gaggatcata atcagccata ccacatttgt agaggtttta 12960 cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 13020 gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 13080 aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 13140 aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctagaagatc cggctgctaa 13200 caaagcccga aaggaagctg agttggctgc tgccaccgct gagcaataac tatcataacc 13260 cctaggagat ccgaaccaga taagtgaaat ctagttccaa actattttgt catttttaat 13320 tttcgtatta gcttacgacg ctacacccag ttcccatcta ttttgtcact cttccctaaa 13380 taatccttaa aaactccatt tccacccctc ccagttccca actattttgt ccgcccaca 13439 <210> 82 <211> 13993 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 82 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccg ccaccatgga 2700 aaactggtcc gctctggaac tgctgcccaa ggtcggaatc cctaccgact tcctgaccca 2760 cgtcaagacc tccgctggcg aggaaatgtt cgaggctctg aggatctact acggcgacga 2820 ccccgagcgt tacaacatcc acttcgaggc tatcttcggc accttctgca accgtctgga 2880 atgggtgtac ttcctgactt ccggcctggc tgctgctgct cacgctatca agttccacga 2940 cctgaacaag ctgaccaccg gcaagatgct gttccacgtg caagtgcccc gtgtggcttc 3000 cggtgctggc ctgcctacct cccgtcagac caccatcatg gtcaccaagt actccgagaa 3060 gtcccccatc accatccctt tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac 3120 cttcgagggc accatcctgg acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg 3180 tgctctgaag aacaccgctg acgctatgga acgtggcctg atccacagct tcctccagac 3240 cctgctgagg aaggctcccc cctacttcgt ggtgcagacc ctggtcgaga acgctaccct 3300 ggctcgtcag gctctgaacc gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa 3360 gatgctggct accctgttcc tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt 3420 cctgacccgt ctggctgagg ctgctaccga ctccatcctc gacaacccta ctacctacac 3480 cacctcctcc ggtgctaaga tctccggtgt catggtgtcc accgctaacg tgatgcagat 3540 catcatgtcc ctgctgtcct cccacatcac taaggaaacc gtgtccgctc ccgctaccta 3600 cggcaacttc gtgctgtccc ccgagaacgc tgtgaccgct atctcctacc actctatcct 3660 ggctgacttc aactcctaca aggctcacct gacctccggc cagccccacc tccccaacga 3720 ctccctgagc caggctggtg ctcactccct gacccccctg tccatggacg tgatccgtct 3780 gggcgaaaag accgtgatca tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa 3840 ggaccccctg gaacgtaacg tggacctgac cttcttcttc cccgtgggcc tgtacctgcc 3900 cgaggaccgt ggttacacca ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa 3960 cgctctgccc accaccgctt acctgctgaa cagggaccgt gctgtgcaaa agatcgactt 4020 cgtggacgct ctcaagaccc tgtgccaccc cgtgctgcac gagcctgctc catgcctgca 4080 ggctttcacc gagcgtggtc ccccatccga gcccgctatg cagcgtctgc tggaatgccg 4140 tttccagcaa gagcccatgg gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg 4200 ccgcgaggtg ccccgtaccg tgaacgagat gaagcaggac ttcgtggtca ccgacttcta 4260 caaggttgga aacatcaccc tgtacaccga gctgcaccct ttcttcgact tcacccactg 4320 ccaagagaac tccgagactg tggctctgtg caccccccgt atcgtgatcg gcaacctgcc 4380 cgacggcctg gctcccggtc ccttccacga gctgaggacc tgggagatca tggaacacat 4440 gcgcctgcgt cccccacccg actacgagga aaccctgcgt ctgttcaaga ccaccgtgac 4500 ctcccccaac taccccgagc tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga 4560 cgctttcctg ctgatccgcg ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg 4620 tcagctgctg gtgttcgctc actcctacgc tctggtcacc ctgatcgctg agcacctggc 4680 tgacggtgct ctgccccccc agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg 4740 cctggtcacc cgtatctccg ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc 4800 cctgtccgct tacgtgaacg ctctgcacga ccacaggctg tggcccccct tcgtgaccca 4860 cctccctcgt aacatggaag gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc 4920 taacatcgag gctcgtcacc acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc 4980 tgacgagccc ctgttcgtgg acgactaccg tgctaccgac gacgagtgga ccctgcaaaa 5040 ggtgttctac ctgtgcctga tccccgctat gaccaacaac cgtgcttgcg gcctgggcct 5100 gaacctcaag actctgctgg tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc 5160 tgctaccgct gtgtccacct ccggcaccac ctccaaggaa tccacctctg gtgtcacccc 5220 cgaggactcc gtggctgctc agcgtcaggc tgtgggcgag atgctgaccg agctggtcga 5280 ggacgtggcc accgacgctc acacccctct gctgcaggct tgccgcgagc tgttcctggc 5340 tgtgcagttc gtgggcgagc acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc 5400 tcagaggcag ggactgcccg acttcatctc ccgtcagcat gtgctgtaca acggttgctg 5460 cgtcgtgacc gctcctaaga ccctgatcga gtactccctg cccgtgccct tccaccgttt 5520 ctactccaac cccaccatct gcgctgctct gtccgacgac atcaagcgtt acgtgaccga 5580 gttcccccac taccatagac acgatggtgg tttccccctg cccaccgctt tcgctcacga 5640 gtaccacaac tggctgcgta gccccttctc ccgttactcc gctacctgcc ccaacgtgct 5700 gcactccgtg atgaccctgg ctgctatgct gtacaagatc tcccccgtgt ccctggtgct 5760 gcagaccaag gctcacatcc accccggttt cgctctgacc gctgtgcgta ccgacacctt 5820 cgaggtggac atgctgctgt actccggcaa gtcctgcacc tccgtcatca tcaacaaccc 5880 catcgtgacc aaggaagaga gggacatctc caccacctac cacgtgaccc agaacatcaa 5940 caccgtggac atgggcctgg gttacacctc caacacttgc gtggcctacg tgaaccgcgt 6000 ccgcaccgac atgggtgtcc gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta 6060 ccgccacgat gaggtggacc gttggatcag gcacgctgct ggcgtcgagc gtccccagct 6120 gctggacacc gagactatct ccatgctgac cttcggttcc atgtccgagc gcaacgctgc 6180 tgctaccgtg cacggccaga aggctgtctg cgagctgatc ctgacccctg tgactatgga 6240 cgtgaactac ttcaagatca ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt 6300 ggacccctac gacaccgagg ctgccaccaa ggctatctac gaccaccgcg aggctgacgc 6360 tcagaccttc gctgctaccc acaacccatg ggcttcccag gctggttgcc tgtccgacgt 6420 cctgtacaac acccgtcacc gcgagcgtct gggctacaac tccaagttct actccccctg 6480 cgctcagtac ttcaacaccg aggaaatcat cgctgccaac aagaccctct tcaagaccat 6540 cgacgagtac ctgctgcgcg ctaaggactg catccgtggc gacaccgaca ctcagtacgt 6600 gtgcgtcgag ggaaccgagc agctgatcga gaacccttgc cgtctgaccc aagaggctct 6660 gcccatcctg tccaccacca ccctggctct gatggaaact aagctgaagg gtggcgctgg 6720 tgctttcgct acctccgaga ctcacttcgg caactacgtc gtgggagaga tcatccccct 6780 gcagcagtcc atgctgttca acagctaaga gctcaagctt gtcgagaagt actagaggat 6840 cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 6900 ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 6960 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 7020 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg 7080 atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 7140 ctgctgtggc tagctttgtt taactttaag aaggagatac atctagaaat attaatagat 7200 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 7260 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 7320 gggcgcggat ccgccaccat ggctgctatg gaagctaaca tcttctgcac cttcgaccac 7380 aagctgtcta tcgctgacgt gggcaagctg accaagctgg tggctgctgt ggtgcccatc 7440 ccccagcgtc tgcacctgat caagcactac cagctgggcc tgcaccagtt cgtggaccac 7500 acccgtggtt acgtgcgtct gcgtggcctg ctgcgtaaca tgaccctgac cctgatgcgt 7560 cgtgtcgagg gcaaccagat cctgctgcac gtgcccaccc acggcctgct gtacaccgtg 7620 ctgaacaccg gtcccgtgac ctgggagaag ggcgacgctc tgtgcgtgct gccccccctg 7680 ttccacggtc ccctggctcg tgaaaacctg ttgaccctgg gccagtggga gctggtgctg 7740 ccctggatcg tgcccatgcc cctggctctg gaaatcaacc agcgcctgct gatcatgggc 7800 ctgttctccc tggaccgttc ctacgaagaa gtgaaggctg ctgtccagca gctgcagacc 7860 atcaccttcc gtgacgctac cttcaccatc cccgaccccg tgatcgacca gcacctcctg 7920 atcgacatga agaccgcttg cctgtccatg tccatggtgg ctaacctggc ttccgagctg 7980 accatgacct acgtccgcaa gctggctttg gaggactctt ccatgctgct ggtcaagtgc 8040 caagagctgc tgatgcgtct ggaccgcgag cgttccgtgg gcgagcctcg tactcccgct 8100 cgtcctcagc acgtgtcccc cgacgacgag atcgctcgtc tgtccgctct gttcgtgatg 8160 ctgcgtcagc tggacgacct gatccgcgag caggtcgtgt tcaccgtgtg cgacgtgagc 8220 ccagacaaca agtccgctac ctgcatcttc aagggctaag gcgcgccaag cttgtcgaga 8280 agtactagag gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa 8340 acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact 8400 tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 8460 aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc 8520 atgtctggat ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag 8580 gaagctgagt tggctgctgg gtgcctaatg agtgagctaa ctcacattaa ttgcccggaa 8640 tattaataga tcatggagat aattaaaatg ataaccatct cgcaaataaa taagtatttt 8700 actgttttcg taacagtttt gtaataaaaa aacctataaa tattccggat tattcatacc 8760 gtcccaccat cgggcgcgga tcccggtccg aagcgcgcgg aattcaaagg cctacgtcga 8820 cgccaccatg tccaacaccg ctcccggtcc caccgtggct aacaagcgtg acgagaagca 8880 ccgtcacgtg gtcaacgtgg tgctcgagct gcccaccgag atctccgagg ctacccaccc 8940 cgtgctggct accatgctgt ccaagtacac ccgtatgtcc tccctgttca acgacaagtg 9000 cgctttcaag ctggacctgc tgcgtatggt ggctgtgtcc cgtacccgtc gctaaaagct 9060 tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc 9120 tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt 9180 tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 9240 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 9300 atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag 9360 cccgaaagga agctgagttg gctgctgggt gcctaatgag tgagctaact cacattaatt 9420 gcccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata 9480 agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta 9540 ttcataccgt cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcaaaggcc 9600 tacgtcgacg ccaccatgga atcccgtggt cgtcgttgcc ccgagatgat ctccgtgctg 9660 ggtcccatct ccggtcacgt cctgaaggct gtgttctccc gtggcgacac ccccgtgctg 9720 ccccacgaaa ctcgtctgct gcagaccggt atccacgtgc gtgtgtccca gccctccctg 9780 atcctggtgt cccagtacac ccccgactcc accccttgcc accgcggaga caaccagctg 9840 caggtccagc acacctactt caccggttcc gaggtcgaga acgtgtccgt gaacgtgcac 9900 aaccccaccg gtcgttccat ctgcccctcc caagagccca tgtccatcta cgtgtacgct 9960 ctgcccctga agatgctgaa catcccctcc atcaacgtgc accactaccc ctccgctgct 10020 gagcgcaagc accgtcacct ccccgtggct gacgctgtga tccacgcttc cggcaagcag 10080 atgtggcagg ctcgtctgac cgtgtccggc ctggcttgga cccgtcagca gaaccagtgg 10140 aaggaacccg acgtgtacta cacctccgct ttcgtgttcc ccaccaagga cgtggccctg 10200 cgtcacgtcg tgtgcgctca cgaactcgtg tgctccatgg aaaacacccg tgctaccaag 10260 atgcaagtga tcggcgacca gtacgtgaag gtgtacctgg aatccttctg cgaggacgtg 10320 ccctccggca agctgttcat gcacgtgacc ctgggttccg acgtggaaga ggacctgacc 10380 atgacccgta acccccagcc cttcatgcgt ccccacgagc gtaacggttt caccgtgctg 10440 tgccccaaga acatgatcat caagcccggc aagatctccc acatcatgct ggacgtggcc 10500 ttcacctccc acgagcactt cggcctgctg tgccctaagt ccatccccgg cctgtccatc 10560 tccggcaacc tgctgatgaa cggccagcag atcttcctgg aagtgcaggc tatccgtgaa 10620 accgtcgagc tgcgtcagta cgaccctgtg gctgctctgt tcttcttcga catcgacctg 10680 ctgctgcagc gtggtcccca gtactccgag caccccacct tcaccagcca gtaccgtatc 10740 cagggcaagc tggaataccg tcacacctgg gaccgtcacg acgagggtgc tgctcagggc 10800 gacgacgacg tgtggacctc cggttccgac tccgacgagg aactggtcac caccgagcgc 10860 aagacccccc gtgtgaccgg tggtggtgct atggctggtg cttccacctc cgctggtcgc 10920 aagcgcaagt ccgcttcctc cgctaccgct tgcaccgctg gtgtcatgac ccgtggtcgc 10980 ctgaaggctg agtccaccgt ggctcccgaa gaggacactg acgaggactc cgacaacgag 11040 atccacaacc ccgctgtgtt cacctggccc ccctggcagg ctggtatcct ggctcgtaac 11100 ctggtgccca tggtggctac cgtgcagggc cagaacctga agtaccaaga gttcttctgg 11160 gacgccaacg acatctaccg tatcttcgct gagctggaag gcgtgtggca gcccgctgct 11220 cagcccaagc gtcgtcgtca ccgtcaggac gctctgcctg gtccctgtat cgcttccacc 11280 cccaagaagc accgcggctc agctgttgaa ttttgacctt cttaagcttg cgggagacgt 11340 cgagtccaac cctgggccca tggccccctc ccacgtggac aaggtgaaca cccgcacctg 11400 gtccgcctcc atcgtgttca tggtgctgac cttcgtgaac gtgtccgtgc acctggtgct 11460 gtccaacttc ccccacctgg gctacccctg cgtgtactac cacgtggtgg acttcgagcg 11520 cctgaacatg tccgcctaca acgtgatgca cctgcacacc cccatgctgt tcctggactc 11580 cgtgcagctg gtgtgctacg ccgtgttcat gcagctggtg ttcctggccg tgaccatcta 11640 ctacctggtg tgctggatca agatctccat gcgcaaggac aagggcatgt ccctgaacca 11700 gtccacccgc gacatctcct acatgggcga ctccctgacc gccttcctgt tcatcctgtc 11760 catggacacc ttccagctgt tcaccctgac catgtccttc cgcctgccct ccatgatcgc 11820 cttcatggcc gccgtgcact tcttctgcct gaccatcttc aacgtgtcca tggtgaccca 11880 gtaccgctcc tacaagcgct ccctgttctt cttctcccgc ctgcacccca agctgaaggg 11940 caccgtgcag ttccgcaccc tgatcgtgaa cctggtggag gtggccctgg gcttcaacac 12000 caccgtggtg gccatggccc tgtgctacgg cttcggcaac aacttcttcg tgcgcaccgg 12060 ccacatggtg ctggccgtgt tcgtggtgta cgccatcatc tccatcatct acttcctgct 12120 gatcgaggcc gtgttcttcc agtacgtgaa ggtgcagttc ggctaccacc tgggcgcctt 12180 cttcggcctg tgcggcctga tctaccccat cgtgcagtac gacaccttcc tgtccaacga 12240 gtaccgcacc ggcatctcct ggtccttcgg catgctgttc ttcatctggg ccatgttcac 12300 cacctgccgc gccgtgcgct acttccgcgg ccgcggctcc ggctccgtga agtaccaggc 12360 cctggccacc gcctccggcg aggaggtggc cgccctgtcc caccacgact ccctggagtc 12420 ccgccgcctg cgcgaggagg aggacgacga cgacgacgag gacttcgagg acgcctaaga 12480 gctcaagctt gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt 12540 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 12600 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 12660 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 12720 catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg 12780 ctaacaaagc ccgaaaggaa gctgagttgg ctgctgtggc tagctttgtt taactttaag 12840 aaggagatac atctagaaat attaatagat catggagata attaaaatga taaccatctc 12900 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 12960 attccggatt attcataccg tcccaccatc gggcgcggat cccggtccga agcgcgcgga 13020 attcaaaggc ctacgccacc atggagtgga acacactagt actaggtctt ttggttttat 13080 cggtagcggc aagttccaac catacgtcga ctgctagcac accgagtccc tctagctcta 13140 ctcacacctc aacgaccgtg aaggcaacga ctactgcgac aactagtaca actacggtga 13200 caagtacgac ttcatcaacg actagtacca aacccggttc caccactcac gaccccaatg 13260 tgatgagacc acatgctcac aatgattttt acaaggcgca ttgtacatcg catatgtatg 13320 aactttctct gtccagcttt gcggcctggt ggactatgct taatgctctc attctcatgg 13380 gagctttttg tatcgtacta cgacattgct gtttccagaa ctttactgca accaccacca 13440 aaggctattg ataaaagctt gtcgagaagt actagaggat cataatcagc cataccacat 13500 ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata 13560 aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa 13620 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 13680 tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa 13740 gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 13800 taactatcat aacccctagg agatccgaac cagataagtg aaatctagtt ccaaactatt 13860 ttgtcatttt taattttcgt attagcttac gacgctacac ccagttccca tctattttgt 13920 cactcttccc taaataatcc ttaaaaactc catttccacc cctcccagtt cccaactatt 13980 ttgtccgccc aca 13993 <210> 83 <211> 14813 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 83 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttactgcagc caccaccaca gggagttcag ggtggacagg 2400 ttcacagcac gacggtgctc agggggggtc aggttgccgt aggtggagga ctgcaggctg 2460 aagttacgga tctcagacag gaacagcagg gagtccaggt agtcccacat ggggtcgatg 2520 aaggtgcgct ggaaacgggt ggatggggag gtgggggtgg tcttgttgtt gtcggaagca 2580 gtctcgttct cgacgggcat ggtgtcgttg tagtacaggg aggacatgtc cagggtgccg 2640 tagatggtgt agggagtctc gttacggatc agcacgtgag tgttcttcat gaactcggac 2700 acagcggtac ggttacggtt gggcttgcag aagggctcgt cacggtaacg cagggtggtg 2760 tacacccagg tagccaggtc cttcagctga gtggtcagga tagacttcat gaagttctcg 2820 tcgggacggt aaccgatggt agaggtgggg atacgggtgg gcacgatggg ggagtaggtc 2880 acgttggtgg aaacgttgaa gatggtggag gtgtaggagg agtagggggt agtagtgctg 2940 acgcgggact tcttggagat ggacttcacg ggagcctgct tgcgcttcag cttgcgcatg 3000 gtgttcttca gcttggtgga gttgatgtac ttgggcacac ggaagatgtt acgggacata 3060 gcgttgacca ggtagaagga acgggtgcag ttgcgctgag cgtaacgcag cagcagagca 3120 gccaggccca ggaagtagat agtctgggag tccacgttga ccttggaggg gcccacgtac 3180 agcttggtgt tccaacgggg cacgttgaag aacatggggt tgaaggtggt gaagttgccg 3240 cagttttcct cgccggtgtt gttacgacgg gacacgttca gcatctcgga caggcaggtc 3300 atggagggga tggtgccgca agagggggga cggaaggtga tcttctggcc ggtgtggttg 3360 tactcggagt acacgtactt agcgggcttg cgcagctggg tggtgtggaa gtcgaaccac 3420 aggtgggtga tggagtggtt acggatggga ccagccagga tggagttggg ggggaactgc 3480 ttcatctcga cggtgatgtt gtacagcttc tgctggctgg ggaaggtgaa gaacttgtag 3540 tagtcgccgg tcttggaagc cagctcttgc aggatacgca gcttcagctg gcgttcctct 3600 tccttagcct tctgggactt cacacggaaa cgagccacag cgatcttgca gttgatgaag 3660 ctgaacagca ggaaggtcag ggacatcagg aagaacaggt tgaacacgcc acgcatctcg 3720 cccttgcgac ccatggtggc ctcgagatcc cgggtgatca agtcttcggt cgagtgattg 3780 taaataaaat gtaatttaca gtatagtatt ttaattaata tacaaatgat ttgataataa 3840 ttcttattta actataatat attgtgttgg gttgaattaa aggtccgtat actagtatcg 3900 attcgcgacc tactccggaa tattaataga tcatggagat aattaaaatg ataaccatct 3960 cgcaaataaa taagtatttt actgttttcg taacagtttt gtaataaaaa aacctataaa 4020 tattccggat tattcatacc gtcccaccat cgggcgcgga tccgccacca tggaaaactg 4080 gtccgctctg gaactgctgc ccaaggtcgg aatccctacc gacttcctga cccacgtcaa 4140 gacctccgct ggcgaggaaa tgttcgaggc tctgaggatc tactacggcg acgaccccga 4200 gcgttacaac atccacttcg aggctatctt cggcaccttc tgcaaccgtc tggaatgggt 4260 gtacttcctg acttccggcc tggctgctgc tgctcacgct atcaagttcc acgacctgaa 4320 caagctgacc accggcaaga tgctgttcca cgtgcaagtg ccccgtgtgg cttccggtgc 4380 tggcctgcct acctcccgtc agaccaccat catggtcacc aagtactccg agaagtcccc 4440 catcaccatc cctttcgagc tgtccgctgc ttgcctgact tacctgcgtg aaaccttcga 4500 gggcaccatc ctggacaaga tcctgaacgt cgaggctatg cacaccgtgc tgcgtgctct 4560 gaagaacacc gctgacgcta tggaacgtgg cctgatccac agcttcctcc agaccctgct 4620 gaggaaggct cccccctact tcgtggtgca gaccctggtc gagaacgcta ccctggctcg 4680 tcaggctctg aaccgtatcc agcgctccaa catcctgcag tccttcaagg ctaagatgct 4740 ggctaccctg ttcctgctga accgtacccg tgaccgtgac tacgtgctga agttcctgac 4800 ccgtctggct gaggctgcta ccgactccat cctcgacaac cctactacct acaccacctc 4860 ctccggtgct aagatctccg gtgtcatggt gtccaccgct aacgtgatgc agatcatcat 4920 gtccctgctg tcctcccaca tcactaagga aaccgtgtcc gctcccgcta cctacggcaa 4980 cttcgtgctg tcccccgaga acgctgtgac cgctatctcc taccactcta tcctggctga 5040 cttcaactcc tacaaggctc acctgacctc cggccagccc cacctcccca acgactccct 5100 gagccaggct ggtgctcact ccctgacccc cctgtccatg gacgtgatcc gtctgggcga 5160 aaagaccgtg atcatggaaa acctgcgtcg cgtgtacaag aacaccgaca ccaaggaccc 5220 cctggaacgt aacgtggacc tgaccttctt cttccccgtg ggcctgtacc tgcccgagga 5280 ccgtggttac accaccgtcg agtccaaggt caagctgaac gacaccgtgc gtaacgctct 5340 gcccaccacc gcttacctgc tgaacaggga ccgtgctgtg caaaagatcg acttcgtgga 5400 cgctctcaag accctgtgcc accccgtgct gcacgagcct gctccatgcc tgcaggcttt 5460 caccgagcgt ggtcccccat ccgagcccgc tatgcagcgt ctgctggaat gccgtttcca 5520 gcaagagccc atgggtggtg ctgctcgtcg tatcccccac ttctaccgtg tgcgccgcga 5580 ggtgccccgt accgtgaacg agatgaagca ggacttcgtg gtcaccgact tctacaaggt 5640 tggaaacatc accctgtaca ccgagctgca ccctttcttc gacttcaccc actgccaaga 5700 gaactccgag actgtggctc tgtgcacccc ccgtatcgtg atcggcaacc tgcccgacgg 5760 cctggctccc ggtcccttcc acgagctgag gacctgggag atcatggaac acatgcgcct 5820 gcgtccccca cccgactacg aggaaaccct gcgtctgttc aagaccaccg tgacctcccc 5880 caactacccc gagctgtgct acctggtgga cgtgctggtg cacggcaacg ctgacgcttt 5940 cctgctgatc cgcgctttca tcgctcgttg catcgtgaac atgttccaca cccgtcagct 6000 gctggtgttc gctcactcct acgctctggt caccctgatc gctgagcacc tggctgacgg 6060 tgctctgccc ccccagctcc tgttccacta ccgtaacctg gtggctgtgc tgcgcctggt 6120 cacccgtatc tccgctctgc ccggcctgaa caacggccag ctggctgagg aacccctgtc 6180 cgcttacgtg aacgctctgc acgaccacag gctgtggccc cccttcgtga cccacctccc 6240 tcgtaacatg gaaggtgtcc aggtggtggc tgatcgtcag cccctgaacc ccgctaacat 6300 cgaggctcgt caccacggtg tctccgacgt gccccgtctg ggtgctatgg acgctgacga 6360 gcccctgttc gtggacgact accgtgctac cgacgacgag tggaccctgc aaaaggtgtt 6420 ctacctgtgc ctgatccccg ctatgaccaa caaccgtgct tgcggcctgg gcctgaacct 6480 caagactctg ctggtggacc tgttctaccg tcccgccttc ctgctcatgc ccgctgctac 6540 cgctgtgtcc acctccggca ccacctccaa ggaatccacc tctggtgtca cccccgagga 6600 ctccgtggct gctcagcgtc aggctgtggg cgagatgctg accgagctgg tcgaggacgt 6660 ggccaccgac gctcacaccc ctctgctgca ggcttgccgc gagctgttcc tggctgtgca 6720 gttcgtgggc gagcacgtga aggtgctgga agtgcgtgct cccctggacc acgctcagag 6780 gcagggactg cccgacttca tctcccgtca gcatgtgctg tacaacggtt gctgcgtcgt 6840 gaccgctcct aagaccctga tcgagtactc cctgcccgtg cccttccacc gtttctactc 6900 caaccccacc atctgcgctg ctctgtccga cgacatcaag cgttacgtga ccgagttccc 6960 ccactaccat agacacgatg gtggtttccc cctgcccacc gctttcgctc acgagtacca 7020 caactggctg cgtagcccct tctcccgtta ctccgctacc tgccccaacg tgctgcactc 7080 cgtgatgacc ctggctgcta tgctgtacaa gatctccccc gtgtccctgg tgctgcagac 7140 caaggctcac atccaccccg gtttcgctct gaccgctgtg cgtaccgaca ccttcgaggt 7200 ggacatgctg ctgtactccg gcaagtcctg cacctccgtc atcatcaaca accccatcgt 7260 gaccaaggaa gagagggaca tctccaccac ctaccacgtg acccagaaca tcaacaccgt 7320 ggacatgggc ctgggttaca cctccaacac ttgcgtggcc tacgtgaacc gcgtccgcac 7380 cgacatgggt gtccgtgtgc aggacctgtt ccgtgtgttc cccatgaacg tgtaccgcca 7440 cgatgaggtg gaccgttgga tcaggcacgc tgctggcgtc gagcgtcccc agctgctgga 7500 caccgagact atctccatgc tgaccttcgg ttccatgtcc gagcgcaacg ctgctgctac 7560 cgtgcacggc cagaaggctg tctgcgagct gatcctgacc cctgtgacta tggacgtgaa 7620 ctacttcaag atcaccaaca accctcgtgg tcgtgcttcc tgcatgctgg gcgtggaccc 7680 ctacgacacc gaggctgcca ccaaggctat ctacgaccac cgcgaggctg acgctcagac 7740 cttcgctgct acccacaacc catgggcttc ccaggctggt tgcctgtccg acgtcctgta 7800 caacacccgt caccgcgagc gtctgggcta caactccaag ttctactccc cctgcgctca 7860 gtacttcaac accgaggaaa tcatcgctgc caacaagacc ctcttcaaga ccatcgacga 7920 gtacctgctg cgcgctaagg actgcatccg tggcgacacc gacactcagt acgtgtgcgt 7980 cgagggaacc gagcagctga tcgagaaccc ttgccgtctg acccaagagg ctctgcccat 8040 cctgtccacc accaccctgg ctctgatgga aactaagctg aagggtggcg ctggtgcttt 8100 cgctacctcc gagactcact tcggcaacta cgtcgtggga gagatcatcc ccctgcagca 8160 gtccatgctg ttcaacagct aagagctcaa gcttgtcgag aagtactaga ggatcataat 8220 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 8280 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 8340 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 8400 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact 8460 gcttgagcct agaagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 8520 tggctagctt tgtttaactt taagaaggag atacatctag aaatattaat agatcatgga 8580 gataattaaa atgataacca tctcgcaaat aaataagtat tttactgttt tcgtaacagt 8640 tttgtaataa aaaaacctat aaatattccg gattattcat accgtcccac catcgggcgc 8700 ggatccgcca ccatggctgc tatggaagct aacatcttct gcaccttcga ccacaagctg 8760 tctatcgctg acgtgggcaa gctgaccaag ctggtggctg ctgtggtgcc catcccccag 8820 cgtctgcacc tgatcaagca ctaccagctg ggcctgcacc agttcgtgga ccacacccgt 8880 ggttacgtgc gtctgcgtgg cctgctgcgt aacatgaccc tgaccctgat gcgtcgtgtc 8940 gagggcaacc agatcctgct gcacgtgccc acccacggcc tgctgtacac cgtgctgaac 9000 accggtcccg tgacctggga gaagggcgac gctctgtgcg tgctgccccc cctgttccac 9060 ggtcccctgg ctcgtgaaaa cctgttgacc ctgggccagt gggagctggt gctgccctgg 9120 atcgtgccca tgcccctggc tctggaaatc aaccagcgcc tgctgatcat gggcctgttc 9180 tccctggacc gttcctacga agaagtgaag gctgctgtcc agcagctgca gaccatcacc 9240 ttccgtgacg ctaccttcac catccccgac cccgtgatcg accagcacct cctgatcgac 9300 atgaagaccg cttgcctgtc catgtccatg gtggctaacc tggcttccga gctgaccatg 9360 acctacgtcc gcaagctggc tttggaggac tcttccatgc tgctggtcaa gtgccaagag 9420 ctgctgatgc gtctggaccg cgagcgttcc gtgggcgagc ctcgtactcc cgctcgtcct 9480 cagcacgtgt cccccgacga cgagatcgct cgtctgtccg ctctgttcgt gatgctgcgt 9540 cagctggacg acctgatccg cgagcaggtc gtgttcaccg tgtgcgacgt gagcccagac 9600 aacaagtccg ctacctgcat cttcaagggc taaggcgcgc caagcttgtc gagaagtact 9660 agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc 9720 cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta 9780 ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat 9840 ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct 9900 ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg aaaggaagct 9960 gagttggctg ctgggtgcct aatgagtgag ctaactcaca ttaattgccc ggaatattaa 10020 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 10080 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 10140 ccatcgggcg cggatcccgg tccgaagcgc gcggaattca aaggcctacg tcgacgccac 10200 catgtccaac accgctcccg gtcccaccgt ggctaacaag cgtgacgaga agcaccgtca 10260 cgtggtcaac gtggtgctcg agctgcccac cgagatctcc gaggctaccc accccgtgct 10320 ggctaccatg ctgtccaagt acacccgtat gtcctccctg ttcaacgaca agtgcgcttt 10380 caagctggac ctgctgcgta tggtggctgt gtcccgtacc cgtcgctaaa agcttgtcga 10440 gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac ttgctttaaa 10500 aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg ttgttgttaa 10560 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 10620 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 10680 tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac aaagcccgaa 10740 aggaagctga gttggctgct gggtgcctaa tgagtgagct aactcacatt aattgcccgg 10800 aatattaata gatcatggag ataattaaaa tgataaccat ctcgcaaata aataagtatt 10860 ttactgtttt cgtaacagtt ttgtaataaa aaaacctata aatattccgg attattcata 10920 ccgtcccacc atcgggcgcg gatcccggtc cgaagcgcgc ggaattcaaa ggcctacgtc 10980 gacgccacca tggaatcccg tggtcgtcgt tgccccgaga tgatctccgt gctgggtccc 11040 atctccggtc acgtcctgaa ggctgtgttc tcccgtggcg acacccccgt gctgccccac 11100 gaaactcgtc tgctgcagac cggtatccac gtgcgtgtgt cccagccctc cctgatcctg 11160 gtgtcccagt acacccccga ctccacccct tgccaccgcg gagacaacca gctgcaggtc 11220 cagcacacct acttcaccgg ttccgaggtc gagaacgtgt ccgtgaacgt gcacaacccc 11280 accggtcgtt ccatctgccc ctcccaagag cccatgtcca tctacgtgta cgctctgccc 11340 ctgaagatgc tgaacatccc ctccatcaac gtgcaccact acccctccgc tgctgagcgc 11400 aagcaccgtc acctccccgt ggctgacgct gtgatccacg cttccggcaa gcagatgtgg 11460 caggctcgtc tgaccgtgtc cggcctggct tggacccgtc agcagaacca gtggaaggaa 11520 cccgacgtgt actacacctc cgctttcgtg ttccccacca aggacgtggc cctgcgtcac 11580 gtcgtgtgcg ctcacgaact cgtgtgctcc atggaaaaca cccgtgctac caagatgcaa 11640 gtgatcggcg accagtacgt gaaggtgtac ctggaatcct tctgcgagga cgtgccctcc 11700 ggcaagctgt tcatgcacgt gaccctgggt tccgacgtgg aagaggacct gaccatgacc 11760 cgtaaccccc agcccttcat gcgtccccac gagcgtaacg gtttcaccgt gctgtgcccc 11820 aagaacatga tcatcaagcc cggcaagatc tcccacatca tgctggacgt ggccttcacc 11880 tcccacgagc acttcggcct gctgtgccct aagtccatcc ccggcctgtc catctccggc 11940 aacctgctga tgaacggcca gcagatcttc ctggaagtgc aggctatccg tgaaaccgtc 12000 gagctgcgtc agtacgaccc tgtggctgct ctgttcttct tcgacatcga cctgctgctg 12060 cagcgtggtc cccagtactc cgagcacccc accttcacca gccagtaccg tatccagggc 12120 aagctggaat accgtcacac ctgggaccgt cacgacgagg gtgctgctca gggcgacgac 12180 gacgtgtgga cctccggttc cgactccgac gaggaactgg tcaccaccga gcgcaagacc 12240 ccccgtgtga ccggtggtgg tgctatggct ggtgcttcca cctccgctgg tcgcaagcgc 12300 aagtccgctt cctccgctac cgcttgcacc gctggtgtca tgacccgtgg tcgcctgaag 12360 gctgagtcca ccgtggctcc cgaagaggac actgacgagg actccgacaa cgagatccac 12420 aaccccgctg tgttcacctg gcccccctgg caggctggta tcctggctcg taacctggtg 12480 cccatggtgg ctaccgtgca gggccagaac ctgaagtacc aagagttctt ctgggacgcc 12540 aacgacatct accgtatctt cgctgagctg gaaggcgtgt ggcagcccgc tgctcagccc 12600 aagcgtcgtc gtcaccgtca ggacgctctg cctggtccct gtatcgcttc cacccccaag 12660 aagcaccgcg gctaaaagct tgtcgagaag tactagagga tcataatcag ccataccaca 12720 tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat 12780 aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa 12840 agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt 12900 ttgtccaaac tcatcaatgt atcttatcat gtctggatct gatcactgct tgagcctaga 12960 agatccggct gctaacaaag cccgaaagga agctgggaat attaatagat caatggagat 13020 aattaaaatg ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt 13080 gtaataaaaa aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga 13140 tccgccacca tggccccctc ccacgtggac aaggtgaaca cccgcacctg gtccgcctcc 13200 atcgtgttca tggtgctgac cttcgtgaac gtgtccgtgc acctggtgct gtccaacttc 13260 ccccacctgg gctacccctg cgtgtactac cacgtggtgg acttcgagcg cctgaacatg 13320 tccgcctaca acgtgatgca cctgcacacc cccatgctgt tcctggactc cgtgcagctg 13380 gtgtgctacg ccgtgttcat gcagctggtg ttcctggccg tgaccatcta ctacctggtg 13440 tgctggatca agatctccat gcgcaaggac aagggcatgt ccctgaacca gtccacccgc 13500 gacatctcct acatgggcga ctccctgacc gccttcctgt tcatcctgtc catggacacc 13560 ttccagctgt tcaccctgac catgtccttc cgcctgccct ccatgatcgc cttcatggcc 13620 gccgtgcact tcttctgcct gaccatcttc aacgtgtcca tggtgaccca gtaccgctcc 13680 tacaagcgct ccctgttctt cttctcccgc ctgcacccca agctgaaggg caccgtgcag 13740 ttccgcaccc tgatcgtgaa cctggtggag gtggccctgg gcttcaacac caccgtggtg 13800 gccatggccc tgtgctacgg cttcggcaac aacttcttcg tgcgcaccgg ccacatggtg 13860 ctggccgtgt tcgtggtgta cgccatcatc tccatcatct acttcctgct gatcgaggcc 13920 gtgttcttcc agtacgtgaa ggtgcagttc ggctaccacc tgggcgcctt cttcggcctg 13980 tgcggcctga tctaccccat cgtgcagtac gacaccttcc tgtccaacga gtaccgcacc 14040 ggcatctcct ggtccttcgg catgctgttc ttcatctggg ccatgttcac cacctgccgc 14100 gccgtgcgct acttccgcgg ccgcggctcc ggctccgtga agtaccaggc cctggccacc 14160 gcctccggcg aggaggtggc cgccctgtcc caccacgact ccctggagtc ccgccgcctg 14220 cgcgaggagg aggacgacga cgacgacgag gacttcgagg acgcctaaga gctcaagctt 14280 gtcgagaagt actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct 14340 ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt 14400 gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc 14460 acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta 14520 tcttatcatg tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc 14580 ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactatcat aacccctagg 14640 agatccgaac cagataagtg aaatctagtt ccaaactatt ttgtcatttt taattttcgt 14700 attagcttac gacgctacac ccagttccca tctattttgt cactcttccc taaataatcc 14760 ttaaaaactc catttccacc cctcccagtt cccaactatt ttgtccgccc aca 14813 <210> 84 <211> 17186 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 84 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc ttactgcagc caccaccaca gggagttcag ggtggacagg 2400 ttcacagcac gacggtgctc agggggggtc aggttgccgt aggtggagga ctgcaggctg 2460 aagttacgga tctcagacag gaacagcagg gagtccaggt agtcccacat ggggtcgatg 2520 aaggtgcgct ggaaacgggt ggatggggag gtgggggtgg tcttgttgtt gtcggaagca 2580 gtctcgttct cgacgggcat ggtgtcgttg tagtacaggg aggacatgtc cagggtgccg 2640 tagatggtgt agggagtctc gttacggatc agcacgtgag tgttcttcat gaactcggac 2700 acagcggtac ggttacggtt gggcttgcag aagggctcgt cacggtaacg cagggtggtg 2760 tacacccagg tagccaggtc cttcagctga gtggtcagga tagacttcat gaagttctcg 2820 tcgggacggt aaccgatggt agaggtgggg atacgggtgg gcacgatggg ggagtaggtc 2880 acgttggtgg aaacgttgaa gatggtggag gtgtaggagg agtagggggt agtagtgctg 2940 acgcgggact tcttggagat ggacttcacg ggagcctgct tgcgcttcag cttgcgcatg 3000 gtgttcttca gcttggtgga gttgatgtac ttgggcacac ggaagatgtt acgggacata 3060 gcgttgacca ggtagaagga acgggtgcag ttgcgctgag cgtaacgcag cagcagagca 3120 gccaggccca ggaagtagat agtctgggag tccacgttga ccttggaggg gcccacgtac 3180 agcttggtgt tccaacgggg cacgttgaag aacatggggt tgaaggtggt gaagttgccg 3240 cagttttcct cgccggtgtt gttacgacgg gacacgttca gcatctcgga caggcaggtc 3300 atggagggga tggtgccgca agagggggga cggaaggtga tcttctggcc ggtgtggttg 3360 tactcggagt acacgtactt agcgggcttg cgcagctggg tggtgtggaa gtcgaaccac 3420 aggtgggtga tggagtggtt acggatggga ccagccagga tggagttggg ggggaactgc 3480 ttcatctcga cggtgatgtt gtacagcttc tgctggctgg ggaaggtgaa gaacttgtag 3540 tagtcgccgg tcttggaagc cagctcttgc aggatacgca gcttcagctg gcgttcctct 3600 tccttagcct tctgggactt cacacggaaa cgagccacag cgatcttgca gttgatgaag 3660 ctgaacagca ggaaggtcag ggacatcagg aagaacaggt tgaacacgcc acgcatctcg 3720 cccttgcgac ccatggtggc ctcgagatcc cgggtgatca agtcttcgtc gagtgattgt 3780 aaataaaatg taatttacag tatagtattt taattaatat acaaatgatt tgataataat 3840 tcttatttaa ctataatata ttgtgttggg ttgaattaaa ggtccgtata ctagtatcga 3900 ttcgcgacct actccggaat attaatagat catggagata attaaaatga taaccatctc 3960 gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa acctataaat 4020 attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat ggaaaactgg 4080 tccgctctgg aactgctgcc caaggtcgga atccctaccg acttcctgac ccacgtcaag 4140 acctccgctg gcgaggaaat gttcgaggct ctgaggatct actacggcga cgaccccgag 4200 cgttacaaca tccacttcga ggctatcttc ggcaccttct gcaaccgtct ggaatgggtg 4260 tacttcctga cttccggcct ggctgctgct gctcacgcta tcaagttcca cgacctgaac 4320 aagctgacca ccggcaagat gctgttccac gtgcaagtgc cccgtgtggc ttccggtgct 4380 ggcctgccta cctcccgtca gaccaccatc atggtcacca agtactccga gaagtccccc 4440 atcaccatcc ctttcgagct gtccgctgct tgcctgactt acctgcgtga aaccttcgag 4500 ggcaccatcc tggacaagat cctgaacgtc gaggctatgc acaccgtgct gcgtgctctg 4560 aagaacaccg ctgacgctat ggaacgtggc ctgatccaca gcttcctcca gaccctgctg 4620 aggaaggctc ccccctactt cgtggtgcag accctggtcg agaacgctac cctggctcgt 4680 caggctctga accgtatcca gcgctccaac atcctgcagt ccttcaaggc taagatgctg 4740 gctaccctgt tcctgctgaa ccgtacccgt gaccgtgact acgtgctgaa gttcctgacc 4800 cgtctggctg aggctgctac cgactccatc ctcgacaacc ctactaccta caccacctcc 4860 tccggtgcta agatctccgg tgtcatggtg tccaccgcta acgtgatgca gatcatcatg 4920 tccctgctgt cctcccacat cactaaggaa accgtgtccg ctcccgctac ctacggcaac 4980 ttcgtgctgt cccccgagaa cgctgtgacc gctatctcct accactctat cctggctgac 5040 ttcaactcct acaaggctca cctgacctcc ggccagcccc acctccccaa cgactccctg 5100 agccaggctg gtgctcactc cctgaccccc ctgtccatgg acgtgatccg tctgggcgaa 5160 aagaccgtga tcatggaaaa cctgcgtcgc gtgtacaaga acaccgacac caaggacccc 5220 ctggaacgta acgtggacct gaccttcttc ttccccgtgg gcctgtacct gcccgaggac 5280 cgtggttaca ccaccgtcga gtccaaggtc aagctgaacg acaccgtgcg taacgctctg 5340 cccaccaccg cttacctgct gaacagggac cgtgctgtgc aaaagatcga cttcgtggac 5400 gctctcaaga ccctgtgcca ccccgtgctg cacgagcctg ctccatgcct gcaggctttc 5460 accgagcgtg gtcccccatc cgagcccgct atgcagcgtc tgctggaatg ccgtttccag 5520 caagagccca tgggtggtgc tgctcgtcgt atcccccact tctaccgtgt gcgccgcgag 5580 gtgccccgta ccgtgaacga gatgaagcag gacttcgtgg tcaccgactt ctacaaggtt 5640 ggaaacatca ccctgtacac cgagctgcac cctttcttcg acttcaccca ctgccaagag 5700 aactccgaga ctgtggctct gtgcaccccc cgtatcgtga tcggcaacct gcccgacggc 5760 ctggctcccg gtcccttcca cgagctgagg acctgggaga tcatggaaca catgcgcctg 5820 cgtcccccac ccgactacga ggaaaccctg cgtctgttca agaccaccgt gacctccccc 5880 aactaccccg agctgtgcta cctggtggac gtgctggtgc acggcaacgc tgacgctttc 5940 ctgctgatcc gcgctttcat cgctcgttgc atcgtgaaca tgttccacac ccgtcagctg 6000 ctggtgttcg ctcactccta cgctctggtc accctgatcg ctgagcacct ggctgacggt 6060 gctctgcccc cccagctcct gttccactac cgtaacctgg tggctgtgct gcgcctggtc 6120 acccgtatct ccgctctgcc cggcctgaac aacggccagc tggctgagga acccctgtcc 6180 gcttacgtga acgctctgca cgaccacagg ctgtggcccc ccttcgtgac ccacctccct 6240 cgtaacatgg aaggtgtcca ggtggtggct gatcgtcagc ccctgaaccc cgctaacatc 6300 gaggctcgtc accacggtgt ctccgacgtg ccccgtctgg gtgctatgga cgctgacgag 6360 cccctgttcg tggacgacta ccgtgctacc gacgacgagt ggaccctgca aaaggtgttc 6420 tacctgtgcc tgatccccgc tatgaccaac aaccgtgctt gcggcctggg cctgaacctc 6480 aagactctgc tggtggacct gttctaccgt cccgccttcc tgctcatgcc cgctgctacc 6540 gctgtgtcca cctccggcac cacctccaag gaatccacct ctggtgtcac ccccgaggac 6600 tccgtggctg ctcagcgtca ggctgtgggc gagatgctga ccgagctggt cgaggacgtg 6660 gccaccgacg ctcacacccc tctgctgcag gcttgccgcg agctgttcct ggctgtgcag 6720 ttcgtgggcg agcacgtgaa ggtgctggaa gtgcgtgctc ccctggacca cgctcagagg 6780 cagggactgc ccgacttcat ctcccgtcag catgtgctgt acaacggttg ctgcgtcgtg 6840 accgctccta agaccctgat cgagtactcc ctgcccgtgc ccttccaccg tttctactcc 6900 aaccccacca tctgcgctgc tctgtccgac gacatcaagc gttacgtgac cgagttcccc 6960 cactaccata gacacgatgg tggtttcccc ctgcccaccg ctttcgctca cgagtaccac 7020 aactggctgc gtagcccctt ctcccgttac tccgctacct gccccaacgt gctgcactcc 7080 gtgatgaccc tggctgctat gctgtacaag atctcccccg tgtccctggt gctgcagacc 7140 aaggctcaca tccaccccgg tttcgctctg accgctgtgc gtaccgacac cttcgaggtg 7200 gacatgctgc tgtactccgg caagtcctgc acctccgtca tcatcaacaa ccccatcgtg 7260 accaaggaag agagggacat ctccaccacc taccacgtga cccagaacat caacaccgtg 7320 gacatgggcc tgggttacac ctccaacact tgcgtggcct acgtgaaccg cgtccgcacc 7380 gacatgggtg tccgtgtgca ggacctgttc cgtgtgttcc ccatgaacgt gtaccgccac 7440 gatgaggtgg accgttggat caggcacgct gctggcgtcg agcgtcccca gctgctggac 7500 accgagacta tctccatgct gaccttcggt tccatgtccg agcgcaacgc tgctgctacc 7560 gtgcacggcc agaaggctgt ctgcgagctg atcctgaccc ctgtgactat ggacgtgaac 7620 tacttcaaga tcaccaacaa ccctcgtggt cgtgcttcct gcatgctggg cgtggacccc 7680 tacgacaccg aggctgccac caaggctatc tacgaccacc gcgaggctga cgctcagacc 7740 ttcgctgcta cccacaaccc atgggcttcc caggctggtt gcctgtccga cgtcctgtac 7800 aacacccgtc accgcgagcg tctgggctac aactccaagt tctactcccc ctgcgctcag 7860 tacttcaaca ccgaggaaat catcgctgcc aacaagaccc tcttcaagac catcgacgag 7920 tacctgctgc gcgctaagga ctgcatccgt ggcgacaccg acactcagta cgtgtgcgtc 7980 gagggaaccg agcagctgat cgagaaccct tgccgtctga cccaagaggc tctgcccatc 8040 ctgtccacca ccaccctggc tctgatggaa actaagctga agggtggcgc tggtgctttc 8100 gctacctccg agactcactt cggcaactac gtcgtgggag agatcatccc cctgcagcag 8160 tccatgctgt tcaacagcta agagctcaag cttgtcgaga agtactagag gatcataatc 8220 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 8280 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 8340 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 8400 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 8460 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgt 8520 ggctagcttt gtttaacttt aagaaggaga tacatctaga ccggaatatt aatagatcat 8580 ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg ttttcgtaac 8640 agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc caccatcggg 8700 cgcggatccc ggtccgaagc gcgcggaatt caaaggccta cgtcgacgcc accatggaat 8760 cccgtggtcg tcgttgcccc gagatgatct ccgtgctggg tcccatctcc ggtcacgtcc 8820 tgaaggctgt gttctcccgt ggcgacaccc ccgtgctgcc ccacgaaact cgtctgctgc 8880 agaccggtat ccacgtgcgt gtgtcccagc cctccctgat cctggtgtcc cagtacaccc 8940 ccgactccac cccttgccac cgcggagaca accagctgca ggtccagcac acctacttca 9000 ccggttccga ggtcgagaac gtgtccgtga acgtgcacaa ccccaccggt cgttccatct 9060 gcccctccca agagcccatg tccatctacg tgtacgctct gcccctgaag atgctgaaca 9120 tcccctccat caacgtgcac cactacccct ccgctgctga gcgcaagcac cgtcacctcc 9180 ccgtggctga cgctgtgatc cacgcttccg gcaagcagat gtggcaggct cgtctgaccg 9240 tgtccggcct ggcttggacc cgtcagcaga accagtggaa ggaacccgac gtgtactaca 9300 cctccgcttt cgtgttcccc accaaggacg tggccctgcg tcacgtcgtg tgcgctcacg 9360 aactcgtgtg ctccatggaa aacacccgtg ctaccaagat gcaagtgatc ggcgaccagt 9420 acgtgaaggt gtacctggaa tccttctgcg aggacgtgcc ctccggcaag ctgttcatgc 9480 acgtgaccct gggttccgac gtggaagagg acctgaccat gacccgtaac ccccagccct 9540 tcatgcgtcc ccacgagcgt aacggtttca ccgtgctgtg ccccaagaac atgatcatca 9600 agcccggcaa gatctcccac atcatgctgg acgtggcctt cacctcccac gagcacttcg 9660 gcctgctgtg ccctaagtcc atccccggcc tgtccatctc cggcaacctg ctgatgaacg 9720 gccagcagat cttcctggaa gtgcaggcta tccgtgaaac cgtcgagctg cgtcagtacg 9780 accctgtggc tgctctgttc ttcttcgaca tcgacctgct gctgcagcgt ggtccccagt 9840 actccgagca ccccaccttc accagccagt accgtatcca gggcaagctg gaataccgtc 9900 acacctggga ccgtcacgac gagggtgctg ctcagggcga cgacgacgtg tggacctccg 9960 gttccgactc cgacgaggaa ctggtcacca ccgagcgcaa gaccccccgt gtgaccggtg 10020 gtggtgctat ggctggtgct tccacctccg ctggtcgcaa gcgcaagtcc gcttcctccg 10080 ctaccgcttg caccgctggt gtcatgaccc gtggtcgcct gaaggctgag tccaccgtgg 10140 ctcccgaaga ggacactgac gaggactccg acaacgagat ccacaacccc gctgtgttca 10200 cctggccccc ctggcaggct ggtatcctgg ctcgtaacct ggtgcccatg gtggctaccg 10260 tgcagggcca gaacctgaag taccaagagt tcttctggga cgccaacgac atctaccgta 10320 tcttcgctga gctggaaggc gtgtggcagc ccgctgctca gcccaagcgt cgtcgtcacc 10380 gtcaggacgc tctgcctggt ccctgtatcg cttccacccc caagaagcac cgcggctaaa 10440 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 10500 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 10560 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 10620 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 10680 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 10740 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccg 10800 gaatattaat agatcatgga gataattaaa atgataacca tctcgcaaat aaataagtat 10860 tttactgttt tcgtaacagt tttgtaataa aaaaacctat aaatattccg gattattcat 10920 accgtcccac catcgggcgc ggatcccggt ccgaagcgcg cggaattcgc caccatgacc 10980 atggacgagc agcagcccca ggctgtgacc cccgtgtacg tgggcggttt cctggctcgt 11040 tacgaccagt cccccgacga ggctgagctg ctgctgccac gtgacgtggt cgaacactgg 11100 ctgcacgctc agggccaggg acagccttcc ctgtccgtgg ctctgcccct gaacatcaac 11160 cacgacgaca ccgctgtcgt gggtcacgtg gccgctatgc agtccgtgcg tgacggcctg 11220 ttctgcctgg gttgcgtgac ctccccccgt ttcctggaaa tcgtgcgtcg tgcttccgag 11280 aagtccgagc tggtgtcccg tggtcccgtg tccccactgc agcccgacaa ggtggtcgag 11340 ttcctgtccg gttcctacgc tggcctgtcc ctgtcatccc gtcgttgcga cgacgtcgag 11400 gctgctacct ccctgagcgg ctccgagact acccccttca agcacgtggc cctgtgctcc 11460 gtgggtcgta ggcgtggaac cctggctgtg tacggtcgtg accccgagtg ggtcacccag 11520 cgtttccccg acctgaccgc tgctgaccgt gacggactgc gtgctcagtg gcagcgttgc 11580 ggttccaccg ctgtggacgc ttccggcgac cccttccgtt ccgactccta cggcctgctg 11640 ggcaactccg tggacgctct gtacatccgc gagcgtctgc ccaagctgcg ttacgacaag 11700 cagctcgtgg gtgtcaccga gcgcgagtcc tacgtgaagg cttccgtgtc ccccgaggct 11760 gcttgcgaca tcaaggctgc ttccgctgag cgttctggcg acagccgctc ccaggctgct 11820 actcctgctg ctggtgctcg tgtgccctcc agctccccat ccccacctgt cgagcctccc 11880 tcccccgtgc aacctcctgc tctgcctgct tccccctccg tgctgcctgc tgagtccagc 11940 ccctccctgt caccctctga gcctgctgag gctgcctcca tgtcccaccc tctgagcgct 12000 gctgtgactg ctgctaccgc tccccctggt gctactgtgg ctggtgcttc ccccgctgtg 12060 ccttccctgg cttggcctca cgacggtgtc tacctgccca aggacgcttt cttctccctg 12120 ctgggcgctt cccgttccgc tgctcccgtg atgtaccccg gtgctgtggc tgctcccccc 12180 agcgcttcac ctgctcctct gcccctgccc tcctaccccg cttcctacgg tgctcccgtc 12240 gtgggttacg accagctggc tgctcgtcac ttcgctgact acgtggaccc ccactacccc 12300 ggctggggtc gtcgttacga gcccgctcct tccctgcacc catcctaccc tgtgccccct 12360 cctccatcac ccgcttacta ccgtcgtcgt gactcccccg gtggcatgga cgagcctcca 12420 tctggatggg agcgttacga cggttcccac cgtggccagt cccaaaagca gcaccgtcac 12480 ggtggttccg gtggtcacaa caagcgtcgc aaggaagccg ctgctgcatc ctccagctcc 12540 gacgaggacc tgagcttccc cggcgaggct gaacacggtc gtgctcgcaa gcgtctgaag 12600 tcccacgtga actccgacgg aggtagcgga ggccacgctg gttccaacca gcagcagcaa 12660 cagcgctacg acgagctgcg tgacgctatc cacgagctga agcgtgacct gttcgctgct 12720 cgccagtcct ccaccctgct gtctgctgct ctgccagctg ccgcttcttc ctcccctacc 12780 accaccaccg tgtgcacccc tactggcgag ctgacctctg gtggtggcga gactcccacc 12840 gctctgctgt ccggtggtgc taaggtggcc gagcgtgctc aggctggtgt cgtgaacgct 12900 tcctgccgtc tggctaccgc ttccggttcc gaggctgcca ccgctggtcc ctctaccgct 12960 ggttcctcat cctgcccagc ttccgtggtg ctggctgccg ctgctgctca agccgccgct 13020 gcttcacagt cccccccaaa ggatatggtg gacctgaacc gtcgtatctt cgtggctgct 13080 ctgaacaagc tcgagtaata aaagcttgtc gagaagtact agaggatcat aatcagccat 13140 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 13200 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 13260 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 13320 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag 13380 cctagaagat ccggctgcta acaaagcccg aaaggaagct gggaatatta atagatcatg 13440 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 13500 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 13560 gcggatccgc caccatggct gctatggaag ctaacatctt ctgcaccttc gaccacaagc 13620 tgtctatcgc tgacgtgggc aagctgacca agctggtggc tgctgtggtg cccatccccc 13680 agcgtctgca cctgatcaag cactaccagc tgggcctgca ccagttcgtg gaccacaccc 13740 gtggttacgt gcgtctgcgt ggcctgctgc gtaacatgac cctgaccctg atgcgtcgtg 13800 tcgagggcaa ccagatcctg ctgcacgtgc ccacccacgg cctgctgtac accgtgctga 13860 acaccggtcc cgtgacctgg gagaagggcg acgctctgtg cgtgctgccc cccctgttcc 13920 acggtcccct ggctcgtgaa aacctgttga ccctgggcca gtgggagctg gtgctgccct 13980 ggatcgtgcc catgcccctg gctctggaaa tcaaccagcg cctgctgatc atgggcctgt 14040 tctccctgga ccgttcctac gaagaagtga aggctgctgt ccagcagctg cagaccatca 14100 ccttccgtga cgctaccttc accatccccg accccgtgat cgaccagcac ctcctgatcg 14160 acatgaagac cgcttgcctg tccatgtcca tggtggctaa cctggcttcc gagctgacca 14220 tgacctacgt ccgcaagctg gctttggagg actcttccat gctgctggtc aagtgccaag 14280 agctgctgat gcgtctggac cgcgagcgtt ccgtgggcga gcctcgtact cccgctcgtc 14340 ctcagcacgt gtcccccgac gacgagatcg ctcgtctgtc cgctctgttc gtgatgctgc 14400 gtcagctgga cgacctgatc cgcgagcagg tcgtgttcac cgtgtgcgac gtgagcccag 14460 acaacaagtc cgctacctgc atcttcaagg gccagctgtt gaattttgac cttcttaagc 14520 ttgcgggaga cgtcgagtcc aaccctgggc ccatggcccc ctcccacgtg gacaaggtga 14580 acacccgcac ctggtccgcc tccatcgtgt tcatggtgct gaccttcgtg aacgtgtccg 14640 tgcacctggt gctgtccaac ttcccccacc tgggctaccc ctgcgtgtac taccacgtgg 14700 tggacttcga gcgcctgaac atgtccgcct acaacgtgat gcacctgcac acccccatgc 14760 tgttcctgga ctccgtgcag ctggtgtgct acgccgtgtt catgcagctg gtgttcctgg 14820 ccgtgaccat ctactacctg gtgtgctgga tcaagatctc catgcgcaag gacaagggca 14880 tgtccctgaa ccagtccacc cgcgacatct cctacatggg cgactccctg accgccttcc 14940 tgttcatcct gtccatggac accttccagc tgttcaccct gaccatgtcc ttccgcctgc 15000 cctccatgat cgccttcatg gccgccgtgc acttcttctg cctgaccatc ttcaacgtgt 15060 ccatggtgac ccagtaccgc tcctacaagc gctccctgtt cttcttctcc cgcctgcacc 15120 ccaagctgaa gggcaccgtg cagttccgca ccctgatcgt gaacctggtg gaggtggccc 15180 tgggcttcaa caccaccgtg gtggccatgg ccctgtgcta cggcttcggc aacaacttct 15240 tcgtgcgcac cggccacatg gtgctggccg tgttcgtggt gtacgccatc atctccatca 15300 tctacttcct gctgatcgag gccgtgttct tccagtacgt gaaggtgcag ttcggctacc 15360 acctgggcgc cttcttcggc ctgtgcggcc tgatctaccc catcgtgcag tacgacacct 15420 tcctgtccaa cgagtaccgc accggcatct cctggtcctt cggcatgctg ttcttcatct 15480 gggccatgtt caccacctgc cgcgccgtgc gctacttccg cggccgcggc tccggctccg 15540 tgaagtacca ggccctggcc accgcctccg gcgaggaggt ggccgccctg tcccaccacg 15600 actccctgga gtcccgccgc ctgcgcgagg aggaggacga cgacgacgac gaggacttcg 15660 aggacgccta agagctcaag cttgtcgaga agtactagag gatcataatc agccatacca 15720 catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac 15780 ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat 15840 aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg 15900 gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta 15960 gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgt ggctagcttt 16020 gtttaacttt aagaaggaga tacatctaga aatattaata gatcatggag ataattaaaa 16080 tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa 16140 aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg gatcccggtc 16200 cgaagcgcgc ggaattcaaa ggcctacgcc accatggagt ggaacacact agtactaggt 16260 cttttggttt tatcggtagc ggcaagttcc aaccatacgt cgactgctag cacaccgagt 16320 ccctctagct ctactcacac ctcaacgacc gtgaaggcaa cgactactgc gacaactagt 16380 acaactacgg tgacaagtac gacttcatca acgactagta ccaaacccgg ttccaccact 16440 cacgacccca atgtgatgag accacatgct cacaatgatt tttacaaggc gcattgtaca 16500 tcgcatatgt atgaactttc tctgtccagc tttgcggcct ggtggactat gcttaatgct 16560 ctcattctca tgggagcttt ttgtatcgta ctacgacatt gctgtttcca gaactttact 16620 gcaaccacca ccaaaggcta ttgataaaag cttgtcgaga agtactagag gatcataatc 16680 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 16740 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 16800 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 16860 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 16920 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgc 16980 caccgctgag caataactat cataacccct aggagatccg aaccagataa gtgaaatcta 17040 gttccaaact attttgtcat ttttaatttt cgtattagct tacgacgcta cacccagttc 17100 ccatctattt tgtcactctt ccctaaataa tccttaaaaa ctccatttcc acccctccca 17160 gttcccaact attttgtccg cccaca 17186 <210> 85 <211> 7308 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 85 aattctgtca gccgttaagt gttcctgtgt cactcaaaat tgctttgaga ggctctaagg 60 gcttctcagt gcgttacatc cctggcttgt tgtccacaac cgttaaacct taaaagcttt 120 aaaagcctta tatattcttt tttttcttat aaaacttaaa accttagagg ctatttaagt 180 tgctgattta tattaatttt attgttcaaa catgagagct tagtacgtga aacatgagag 240 cttagtacgt tagccatgag agcttagtac gttagccatg agggtttagt tcgttaaaca 300 tgagagctta gtacgttaaa catgagagct tagtacgtga aacatgagag cttagtacgt 360 actatcaaca ggttgaactg ctgatcaaca gatcctctac gcggccgcgg taccataact 420 tcgtatagca tacattatac gaagttatct ggtttaaacg tacccgtagt ggctatggca 480 gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt cacccgaact tgggggttgg 540 ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat ggggtctcgg tggggtatcg 600 acagagtgcc agccctggga ccgaaccccg cgtttatgaa caaacgaccc aacacccgtg 660 cgttttattc tgtcttttta ttgccgtcat agcgcgggtt ccttccggta ttgtctcctt 720 ccgtgtttca gttagcctcc cccatctccc ggtaccgcat gctatgcatc agctgctagc 780 accatggctc gagatcccgg gtgatcaagt cttcgtcgag tgattgtaaa taaaatgtaa 840 tttacagtat agtattttaa ttaatataca aatgatttga taataattct tatttaacta 900 taatatattg tgttgggttg aattaaaggt ccgtatacta gtatcgattc gcgacctact 960 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 1020 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 1080 cataccgtcc caccatcggg cgcggatccc ggtccgaagc gcgcggaatt caaaggccta 1140 ccgtcgacgc caccatggaa tcccgtggtc gtcgttgccc cgagatgatc tccgtgctgg 1200 gtcccatctc cggtcacgtc ctgaaggctg tgttctcccg tggcgacacc cccgtgctgc 1260 cccacgaaac tcgtctgctg cagaccggta tccacgtgcg tgtgtcccag ccctccctga 1320 tcctggtgtc ccagtacacc cccgactcca ccccttgcca ccgcggagac aaccagctgc 1380 aggtccagca cacctacttc accggttccg aggtcgagaa cgtgtccgtg aacgtgcaca 1440 accccaccgg tcgttccatc tgcccctccc aagagcccat gtccatctac gtgtacgctc 1500 tgcccctgaa gatgctgaac atcccctcca tcaacgtgca ccactacccc tccgctgctg 1560 agcgcaagca ccgtcacctc cccgtggctg acgctgtgat ccacgcttcc ggcaagcaga 1620 tgtggcaggc tcgtctgacc gtgtccggcc tggcttggac ccgtcagcag aaccagtgga 1680 aggaacccga cgtgtactac acctccgctt tcgtgttccc caccaaggac gtggccctgc 1740 gtcacgtcgt gtgcgctcac gaactcgtgt gctccatgga aaacacccgt gctaccaaga 1800 tgcaagtgat cggcgaccag tacgtgaagg tgtacctgga atccttctgc gaggacgtgc 1860 cctccggcaa gctgttcatg cacgtgaccc tgggttccga cgtggaagag gacctgacca 1920 tgacccgtaa cccccagccc ttcatgcgtc cccacgagcg taacggtttc accgtgctgt 1980 gccccaagaa catgatcatc aagcccggca agatctccca catcatgctg gacgtggcct 2040 tcacctccca cgagcacttc ggcctgctgt gccctaagtc catccccggc ctgtccatct 2100 ccggcaacct gctgatgaac ggccagcaga tcttcctgga agtgcaggct atccgtgaaa 2160 ccgtcgagct gcgtcagtac gaccctgtgg ctgctctgtt cttcttcgac atcgacctgc 2220 tgctgcagcg tggtccccag tactccgagc accccacctt caccagccag taccgtatcc 2280 agggcaagct ggaataccgt cacacctggg accgtcacga cgagggtgct gctcagggcg 2340 acgacgacgt gtggacctcc ggttccgact ccgacgagga actggtcacc accgagcgca 2400 agaccccccg tgtgaccggt ggtggtgcta tggctggtgc ttccacctcc gctggtcgca 2460 agcgcaagtc cgcttcctcc gctaccgctt gcaccgctgg tgtcatgacc cgtggtcgcc 2520 tgaaggctga gtccaccgtg gctcccgaag aggacactga cgaggactcc gacaacgaga 2580 tccacaaccc cgctgtgttc acctggcccc cctggcaggc tggtatcctg gctcgtaacc 2640 tggtgcccat ggtggctacc gtgcagggcc agaacctgaa gtaccaagag ttcttctggg 2700 acgccaacga catctaccgt atcttcgctg agctggaagg cgtgtggcag cccgctgctc 2760 agcccaagcg tcgtcgtcac cgtcaggacg ctctgcctgg tccctgtatc gcttccaccc 2820 ccaagaagca ccgcggctaa aagcttgtcg agaagtacta gaggatcata atcagccata 2880 ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga 2940 aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca 3000 aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt 3060 gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc 3120 ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc tgtggctagc 3180 tttgtttaac tttaagaagg agatacatct agacctgcag gccggaatat taatagatca 3240 tggagataat taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa 3300 cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg 3360 gcgcggatcc cggtccgaag cgcgcggaat tcgccaccat gaccatggac gagcagcagc 3420 cccaggctgt gacccccgtg tacgtgggcg gtttcctggc tcgttacgac cagtcccccg 3480 acgaggctga gctgctgctg ccacgtgacg tggtcgaaca ctggctgcac gctcagggcc 3540 agggacagcc ttccctgtcc gtggctctgc ccctgaacat caaccacgac gacaccgctg 3600 tcgtgggtca cgtggccgct atgcagtccg tgcgtgacgg cctgttctgc ctgggttgcg 3660 tgacctcccc ccgtttcctg gaaatcgtgc gtcgtgcttc cgagaagtcc gagctggtgt 3720 cccgtggtcc cgtgtcccca ctgcagcccg acaaggtggt cgagttcctg tccggttcct 3780 acgctggcct gtccctgtca tcccgtcgtt gcgacgacgt cgaggctgct acctccctga 3840 gcggctccga gactaccccc ttcaagcacg tggccctgtg ctccgtgggt cgtaggcgtg 3900 gaaccctggc tgtgtacggt cgtgaccccg agtgggtcac ccagcgtttc cccgacctga 3960 ccgctgctga ccgtgacgga ctgcgtgctc agtggcagcg ttgcggttcc accgctgtgg 4020 acgcttccgg cgaccccttc cgttccgact cctacggcct gctgggcaac tccgtggacg 4080 ctctgtacat ccgcgagcgt ctgcccaagc tgcgttacga caagcagctc gtgggtgtca 4140 ccgagcgcga gtcctacgtg aaggcttccg tgtcccccga ggctgcttgc gacatcaagg 4200 ctgcttccgc tgagcgttct ggcgacagcc gctcccaggc tgctactcct gctgctggtg 4260 ctcgtgtgcc ctccagctcc ccatccccac ctgtcgagcc tccctccccc gtgcaacctc 4320 ctgctctgcc tgcttccccc tccgtgctgc ctgctgagtc cagcccctcc ctgtcaccct 4380 ctgagcctgc tgaggctgcc tccatgtccc accctctgag cgctgctgtg actgctgcta 4440 ccgctccccc tggtgctact gtggctggtg cttcccccgc tgtgccttcc ctggcttggc 4500 ctcacgacgg tgtctacctg cccaaggacg ctttcttctc cctgctgggc gcttcccgtt 4560 ccgctgctcc cgtgatgtac cccggtgctg tggctgctcc ccccagcgct tcacctgctc 4620 ctctgcccct gccctcctac cccgcttcct acggtgctcc cgtcgtgggt tacgaccagc 4680 tggctgctcg tcacttcgct gactacgtgg acccccacta ccccggctgg ggtcgtcgtt 4740 acgagcccgc tccttccctg cacccatcct accctgtgcc ccctcctcca tcacccgctt 4800 actaccgtcg tcgtgactcc cccggtggca tggacgagcc tccatctgga tgggagcgtt 4860 acgacggttc ccaccgtggc cagtcccaaa agcagcaccg tcacggtggt tccggtggtc 4920 acaacaagcg tcgcaaggaa gccgctgctg catcctccag ctccgacgag gacctgagct 4980 tccccggcga ggctgaacac ggtcgtgctc gcaagcgtct gaagtcccac gtgaactccg 5040 acggaggtag cggaggccac gctggttcca accagcagca gcaacagcgc tacgacgagc 5100 tgcgtgacgc tatccacgag ctgaagcgtg acctgttcgc tgctcgccag tcctccaccc 5160 tgctgtctgc tgctctgcca gctgccgctt cttcctcccc taccaccacc accgtgtgca 5220 cccctactgg cgagctgacc tctggtggtg gcgagactcc caccgctctg ctgtccggtg 5280 gtgctaaggt ggccgagcgt gctcaggctg gtgtcgtgaa cgcttcctgc cgtctggcta 5340 ccgcttccgg ttccgaggct gccaccgctg gtccctctac cgctggttcc tcatcctgcc 5400 cagcttccgt ggtgctggct gccgctgctg ctcaagccgc cgctgcttca cagtcccccc 5460 caaaggatat ggtggacctg aaccgtcgta tcttcgtggc tgctctgaac aagctcgagt 5520 aataaaagct tgtcgagaag tactagagga tcataatcag ccataccaca tttgtagagg 5580 ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg 5640 caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca 5700 tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac 5760 tcatcaatgt atcttatcat gtctggatct gatcactgct tgagcctaga agatccggct 5820 gctaacaaag cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactatca 5880 taacccctag gggcctctaa acgggtcttg aggggttttt tgctgaaagg aggaactata 5940 tccggatctg aacaggaggg acagctgata gaaacagaag ccactggagc acctcaaaaa 6000 caccatcata cactaaatca gtaagttggc agcatcaccc gacgcacttt gcgccgaata 6060 aatacctgtg acggaagatc acttcgcaga ataaataaat cctggtgtcc ctgttgatac 6120 cgggaagccc tgggccaact tttggcgaaa atgagacgtt gatcggcacg taagaggttc 6180 caactttcac cataatgaaa taagatcact accgggcgta ttttttgagt tatcgagatt 6240 ttcaggagct aaggaagcta aaatggagaa aaaaatcact ggatatacca ccgttgatat 6300 atcccaatgg catcgtaaag aacattttga ggcatttcag tcagttgctc aatgtaccta 6360 taaccagacc gttcagctgg atattacggc ctttttaaag accgtaaaga aaaataagca 6420 caagttttat ccggccttta ttcacattct tgcccgcctg atgaatgctc atccggaatt 6480 ccgtatggca atgaaagacg gtgagctggt gatatgggat agtgttcacc cttgttacac 6540 cgttttccat gagcaaactg aaacgttttc atcgctctgg agtgaatacc acgacgattt 6600 ccggcagttt ctacacatat attcgcaaga tgtggcgtgt tacggtgaaa acctggccta 6660 tttccctaaa gggtttattg agaatatgtt tttcgtctca gccaatccct gggtgagttt 6720 caccagtttt gatttaaacg tggccaatat ggacaacttc ttcgcccccg ttttcaccat 6780 gggcaaatat tatacgcaag gcgacaaggt gctgatgccg ctggcgattc aggttcatca 6840 tgccgtttgt gatggcttcc atgtcggcag aatgcttaat gaattacaac agtactgcga 6900 tgagtggcag ggcggggcgt aattttttta aggcagttat tggtgccctt aaacgcctgg 6960 ttgctacgcc tgaataagtg ataataagcg gatgaatggc agaaattcga aagcaaattc 7020 gacccggtcg tcggttcagg gcagggtcgt taaatagccg cttatgtcta ttgctggttt 7080 accggtttat tgactaccgg aagcagtgtg accgtgtgct tctcaaatgc ctgaggccag 7140 tttgctcagg ctctccccgt ggaggtaata attgacgata tgatcattta ttctgcctcc 7200 cagctgacat tcatccgggg tcagcaccgt ttctgcggac tggctttcta cgtgttccgc 7260 ttcctttagc agcccttgcg ccctgagtgc ttgcggcagc gtgaagct 7308 <210> 86 <211> 8470 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 86 aattctgtca gccgttaagt gttcctgtgt cactcaaaat tgctttgaga ggctctaagg 60 gcttctcagt gcgttacatc cctggcttgt tgtccacaac cgttaaacct taaaagcttt 120 aaaagcctta tatattcttt tttttcttat aaaacttaaa accttagagg ctatttaagt 180 tgctgattta tattaatttt attgttcaaa catgagagct tagtacgtga aacatgagag 240 cttagtacgt tagccatgag agcttagtac gttagccatg agggtttagt tcgttaaaca 300 tgagagctta gtacgttaaa catgagagct tagtacgtga aacatgagag cttagtacgt 360 actatcaaca ggttgaactg ctgatcaaca gatcctctac gcggccgcgg taccataact 420 tcgtatagca tacattatac gaagttatct ggtttaaacg tacccgtagt ggctatggca 480 gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt cacccgaact tgggggttgg 540 ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat ggggtctcgg tggggtatcg 600 acagagtgcc agccctggga ccgaaccccg cgtttatgaa caaacgaccc aacacccgtg 660 cgttttattc tgtcttttta ttgccgtcat agcgcgggtt ccttccggta ttgtctcctt 720 ccgtgtttca gttagcctcc cccatctccc ggtaccgcat gctatgcatc agctgctagc 780 accatggctc gagatcccgg gtgatcaagt cttcgtcgag tgattgtaaa taaaatgtaa 840 tttacagtat agtattttaa ttaatataca aatgatttga taataattct tatttaacta 900 taatatattg tgttgggttg aattaaaggt ccgtatacta gtatcgattc gcgacctact 960 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 1020 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 1080 cataccgtcc caccatcggg cgcggatccg ccaccatgga aaactggtcc gctctggaac 1140 tgctgcccaa ggtcggaatc cctaccgact tcctgaccca cgtcaagacc tccgctggcg 1200 aggaaatgtt cgaggctctg aggatctact acggcgacga ccccgagcgt tacaacatcc 1260 acttcgaggc tatcttcggc accttctgca accgtctgga atgggtgtac ttcctgactt 1320 ccggcctggc tgctgctgct cacgctatca agttccacga cctgaacaag ctgaccaccg 1380 gcaagatgct gttccacgtg caagtgcccc gtgtggcttc cggtgctggc ctgcctacct 1440 cccgtcagac caccatcatg gtcaccaagt actccgagaa gtcccccatc accatccctt 1500 tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac cttcgagggc accatcctgg 1560 acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg tgctctgaag aacaccgctg 1620 acgctatgga acgtggcctg atccacagct tcctccagac cctgctgagg aaggctcccc 1680 cctacttcgt ggtgcagacc ctggtcgaga acgctaccct ggctcgtcag gctctgaacc 1740 gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa gatgctggct accctgttcc 1800 tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt cctgacccgt ctggctgagg 1860 ctgctaccga ctccatcctc gacaacccta ctacctacac cacctcctcc ggtgctaaga 1920 tctccggtgt catggtgtcc accgctaacg tgatgcagat catcatgtcc ctgctgtcct 1980 cccacatcac taaggaaacc gtgtccgctc ccgctaccta cggcaacttc gtgctgtccc 2040 ccgagaacgc tgtgaccgct atctcctacc actctatcct ggctgacttc aactcctaca 2100 aggctcacct gacctccggc cagccccacc tccccaacga ctccctgagc caggctggtg 2160 ctcactccct gacccccctg tccatggacg tgatccgtct gggcgaaaag accgtgatca 2220 tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa ggaccccctg gaacgtaacg 2280 tggacctgac cttcttcttc cccgtgggcc tgtacctgcc cgaggaccgt ggttacacca 2340 ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa cgctctgccc accaccgctt 2400 acctgctgaa cagggaccgt gctgtgcaaa agatcgactt cgtggacgct ctcaagaccc 2460 tgtgccaccc cgtgctgcac gagcctgctc catgcctgca ggctttcacc gagcgtggtc 2520 ccccatccga gcccgctatg cagcgtctgc tggaatgccg tttccagcaa gagcccatgg 2580 gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg ccgcgaggtg ccccgtaccg 2640 tgaacgagat gaagcaggac ttcgtggtca ccgacttcta caaggttgga aacatcaccc 2700 tgtacaccga gctgcaccct ttcttcgact tcacccactg ccaagagaac tccgagactg 2760 tggctctgtg caccccccgt atcgtgatcg gcaacctgcc cgacggcctg gctcccggtc 2820 ccttccacga gctgaggacc tgggagatca tggaacacat gcgcctgcgt cccccacccg 2880 actacgagga aaccctgcgt ctgttcaaga ccaccgtgac ctcccccaac taccccgagc 2940 tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga cgctttcctg ctgatccgcg 3000 ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg tcagctgctg gtgttcgctc 3060 actcctacgc tctggtcacc ctgatcgctg agcacctggc tgacggtgct ctgccccccc 3120 agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg cctggtcacc cgtatctccg 3180 ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc cctgtccgct tacgtgaacg 3240 ctctgcacga ccacaggctg tggcccccct tcgtgaccca cctccctcgt aacatggaag 3300 gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc taacatcgag gctcgtcacc 3360 acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc tgacgagccc ctgttcgtgg 3420 acgactaccg tgctaccgac gacgagtgga ccctgcaaaa ggtgttctac ctgtgcctga 3480 tccccgctat gaccaacaac cgtgcttgcg gcctgggcct gaacctcaag actctgctgg 3540 tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc tgctaccgct gtgtccacct 3600 ccggcaccac ctccaaggaa tccacctctg gtgtcacccc cgaggactcc gtggctgctc 3660 agcgtcaggc tgtgggcgag atgctgaccg agctggtcga ggacgtggcc accgacgctc 3720 acacccctct gctgcaggct tgccgcgagc tgttcctggc tgtgcagttc gtgggcgagc 3780 acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc tcagaggcag ggactgcccg 3840 acttcatctc ccgtcagcat gtgctgtaca acggttgctg cgtcgtgacc gctcctaaga 3900 ccctgatcga gtactccctg cccgtgccct tccaccgttt ctactccaac cccaccatct 3960 gcgctgctct gtccgacgac atcaagcgtt acgtgaccga gttcccccac taccatagac 4020 acgatggtgg tttccccctg cccaccgctt tcgctcacga gtaccacaac tggctgcgta 4080 gccccttctc ccgttactcc gctacctgcc ccaacgtgct gcactccgtg atgaccctgg 4140 ctgctatgct gtacaagatc tcccccgtgt ccctggtgct gcagaccaag gctcacatcc 4200 accccggttt cgctctgacc gctgtgcgta ccgacacctt cgaggtggac atgctgctgt 4260 actccggcaa gtcctgcacc tccgtcatca tcaacaaccc catcgtgacc aaggaagaga 4320 gggacatctc caccacctac cacgtgaccc agaacatcaa caccgtggac atgggcctgg 4380 gttacacctc caacacttgc gtggcctacg tgaaccgcgt ccgcaccgac atgggtgtcc 4440 gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta ccgccacgat gaggtggacc 4500 gttggatcag gcacgctgct ggcgtcgagc gtccccagct gctggacacc gagactatct 4560 ccatgctgac cttcggttcc atgtccgagc gcaacgctgc tgctaccgtg cacggccaga 4620 aggctgtctg cgagctgatc ctgacccctg tgactatgga cgtgaactac ttcaagatca 4680 ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt ggacccctac gacaccgagg 4740 ctgccaccaa ggctatctac gaccaccgcg aggctgacgc tcagaccttc gctgctaccc 4800 acaacccatg ggcttcccag gctggttgcc tgtccgacgt cctgtacaac acccgtcacc 4860 gcgagcgtct gggctacaac tccaagttct actccccctg cgctcagtac ttcaacaccg 4920 aggaaatcat cgctgccaac aagaccctct tcaagaccat cgacgagtac ctgctgcgcg 4980 ctaaggactg catccgtggc gacaccgaca ctcagtacgt gtgcgtcgag ggaaccgagc 5040 agctgatcga gaacccttgc cgtctgaccc aagaggctct gcccatcctg tccaccacca 5100 ccctggctct gatggaaact aagctgaagg gtggcgctgg tgctttcgct acctccgaga 5160 ctcacttcgg caactacgtc gtgggagaga tcatccccct gcagcagtcc atgctgttca 5220 acagctaaga gctcaagctt gtcgagaagt actagaggat cataatcagc cataccacat 5280 ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata 5340 aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa 5400 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 5460 tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa 5520 gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgtggc tagctttgtt 5580 taactttaag aaggagatac atctagaaat attaatagat catggagata attaaaatga 5640 taaccatctc gcaaataaat aagtatttta ctgttttcgt aacagttttg taataaaaaa 5700 acctataaat attccggatt attcataccg tcccaccatc gggcgcggat ccgccaccat 5760 ggctgctatg gaagctaaca tcttctgcac cttcgaccac aagctgtcta tcgctgacgt 5820 gggcaagctg accaagctgg tggctgctgt ggtgcccatc ccccagcgtc tgcacctgat 5880 caagcactac cagctgggcc tgcaccagtt cgtggaccac acccgtggtt acgtgcgtct 5940 gcgtggcctg ctgcgtaaca tgaccctgac cctgatgcgt cgtgtcgagg gcaaccagat 6000 cctgctgcac gtgcccaccc acggcctgct gtacaccgtg ctgaacaccg gtcccgtgac 6060 ctgggagaag ggcgacgctc tgtgcgtgct gccccccctg ttccacggtc ccctggctcg 6120 tgaaaacctg ttgaccctgg gccagtggga gctggtgctg ccctggatcg tgcccatgcc 6180 cctggctctg gaaatcaacc agcgcctgct gatcatgggc ctgttctccc tggaccgttc 6240 ctacgaagaa gtgaaggctg ctgtccagca gctgcagacc atcaccttcc gtgacgctac 6300 cttcaccatc cccgaccccg tgatcgacca gcacctcctg atcgacatga agaccgcttg 6360 cctgtccatg tccatggtgg ctaacctggc ttccgagctg accatgacct acgtccgcaa 6420 gctggctttg gaggactctt ccatgctgct ggtcaagtgc caagagctgc tgatgcgtct 6480 ggaccgcgag cgttccgtgg gcgagcctcg tactcccgct cgtcctcagc acgtgtcccc 6540 cgacgacgag atcgctcgtc tgtccgctct gttcgtgatg ctgcgtcagc tggacgacct 6600 gatccgcgag caggtcgtgt tcaccgtgtg cgacgtgagc ccagacaaca agtccgctac 6660 ctgcatcttc aagggctaag gcgcgccaag cttgtcgaga agtactagag gatcataatc 6720 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 6780 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 6840 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 6900 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg 6960 cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgc 7020 caccgctgag caataactat cataacccct aggggcctct aaacgggtct tgaggggttt 7080 tttgctgaaa ggaggaacta tatccggatc tgaacaggag ggacagctga tagaaacaga 7140 agccactgga gcacctcaaa aacaccatca tacactaaat cagtaagttg gcagcatcac 7200 ccgacgcact ttgcgccgaa taaatacctg tgacggaaga tcacttcgca gaataaataa 7260 atcctggtgt ccctgttgat accgggaagc cctgggccaa cttttggcga aaatgagacg 7320 ttgatcggca cgtaagaggt tccaactttc accataatga aataagatca ctaccgggcg 7380 tattttttga gttatcgaga ttttcaggag ctaaggaagc taaaatggag aaaaaaatca 7440 ctggatatac caccgttgat atatcccaat ggcatcgtaa agaacatttt gaggcatttc 7500 agtcagttgc tcaatgtacc tataaccaga ccgttcagct ggatattacg gcctttttaa 7560 agaccgtaaa gaaaaataag cacaagtttt atccggcctt tattcacatt cttgcccgcc 7620 tgatgaatgc tcatccggaa ttccgtatgg caatgaaaga cggtgagctg gtgatatggg 7680 atagtgttca cccttgttac accgttttcc atgagcaaac tgaaacgttt tcatcgctct 7740 ggagtgaata ccacgacgat ttccggcagt ttctacacat atattcgcaa gatgtggcgt 7800 gttacggtga aaacctggcc tatttcccta aagggtttat tgagaatatg tttttcgtct 7860 cagccaatcc ctgggtgagt ttcaccagtt ttgatttaaa cgtggccaat atggacaact 7920 tcttcgcccc cgttttcacc atgggcaaat attatacgca aggcgacaag gtgctgatgc 7980 cgctggcgat tcaggttcat catgccgttt gtgatggctt ccatgtcggc agaatgctta 8040 atgaattaca acagtactgc gatgagtggc agggcggggc gtaatttttt taaggcagtt 8100 attggtgccc ttaaacgcct ggttgctacg cctgaataag tgataataag cggatgaatg 8160 gcagaaattc gaaagcaaat tcgacccggt cgtcggttca gggcagggtc gttaaatagc 8220 cgcttatgtc tattgctggt ttaccggttt attgactacc ggaagcagtg tgaccgtgtg 8280 cttctcaaat gcctgaggcc agtttgctca ggctctcccc gtggaggtaa taattgacga 8340 tatgatcatt tattctgcct cccagctgac attcatccgg ggtcagcacc gtttctgcgg 8400 actggctttc tacgtgttcc gcttccttta gcagcccttg cgccctgagt gcttgcggca 8460 gcgtgaagct 8470 <210> 87 <211> 9702 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 87 aattctgtca gccgttaagt gttcctgtgt cactcaaaat tgctttgaga ggctctaagg 60 gcttctcagt gcgttacatc cctggcttgt tgtccacaac cgttaaacct taaaagcttt 120 aaaagcctta tatattcttt tttttcttat aaaacttaaa accttagagg ctatttaagt 180 tgctgattta tattaatttt attgttcaaa catgagagct tagtacgtga aacatgagag 240 cttagtacgt tagccatgag agcttagtac gttagccatg agggtttagt tcgttaaaca 300 tgagagctta gtacgttaaa catgagagct tagtacgtga aacatgagag cttagtacgt 360 actatcaaca ggttgaactg ctgatcaaca gatcctctac gcggccgcgg taccataact 420 tcgtatagca tacattatac gaagttatct ggtttaaacg tacccgtagt ggctatggca 480 gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt cacccgaact tgggggttgg 540 ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat ggggtctcgg tggggtatcg 600 acagagtgcc agccctggga ccgaaccccg cgtttatgaa caaacgaccc aacacccgtg 660 cgttttattc tgtcttttta ttgccgtcat agcgcgggtt ccttccggta ttgtctcctt 720 ccgtgtttca gttagcctcc cccatctccc ggtaccgcat gctatgcatc agctgctagc 780 accatggctc gagatcccgg gtgatcaagt cttcgtcgag tgattgtaaa taaaatgtaa 840 tttacagtat agtattttaa ttaatataca aatgatttga taataattct tatttaacta 900 taatatattg tgttgggttg aattaaaggt ccgtatacta gtatcgattc gcgacctact 960 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 1020 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 1080 cataccgtcc caccatcggg cgcggatccg ccaccatgga aaactggtcc gctctggaac 1140 tgctgcccaa ggtcggaatc cctaccgact tcctgaccca cgtcaagacc tccgctggcg 1200 aggaaatgtt cgaggctctg aggatctact acggcgacga ccccgagcgt tacaacatcc 1260 acttcgaggc tatcttcggc accttctgca accgtctgga atgggtgtac ttcctgactt 1320 ccggcctggc tgctgctgct cacgctatca agttccacga cctgaacaag ctgaccaccg 1380 gcaagatgct gttccacgtg caagtgcccc gtgtggcttc cggtgctggc ctgcctacct 1440 cccgtcagac caccatcatg gtcaccaagt actccgagaa gtcccccatc accatccctt 1500 tcgagctgtc cgctgcttgc ctgacttacc tgcgtgaaac cttcgagggc accatcctgg 1560 acaagatcct gaacgtcgag gctatgcaca ccgtgctgcg tgctctgaag aacaccgctg 1620 acgctatgga acgtggcctg atccacagct tcctccagac cctgctgagg aaggctcccc 1680 cctacttcgt ggtgcagacc ctggtcgaga acgctaccct ggctcgtcag gctctgaacc 1740 gtatccagcg ctccaacatc ctgcagtcct tcaaggctaa gatgctggct accctgttcc 1800 tgctgaaccg tacccgtgac cgtgactacg tgctgaagtt cctgacccgt ctggctgagg 1860 ctgctaccga ctccatcctc gacaacccta ctacctacac cacctcctcc ggtgctaaga 1920 tctccggtgt catggtgtcc accgctaacg tgatgcagat catcatgtcc ctgctgtcct 1980 cccacatcac taaggaaacc gtgtccgctc ccgctaccta cggcaacttc gtgctgtccc 2040 ccgagaacgc tgtgaccgct atctcctacc actctatcct ggctgacttc aactcctaca 2100 aggctcacct gacctccggc cagccccacc tccccaacga ctccctgagc caggctggtg 2160 ctcactccct gacccccctg tccatggacg tgatccgtct gggcgaaaag accgtgatca 2220 tggaaaacct gcgtcgcgtg tacaagaaca ccgacaccaa ggaccccctg gaacgtaacg 2280 tggacctgac cttcttcttc cccgtgggcc tgtacctgcc cgaggaccgt ggttacacca 2340 ccgtcgagtc caaggtcaag ctgaacgaca ccgtgcgtaa cgctctgccc accaccgctt 2400 acctgctgaa cagggaccgt gctgtgcaaa agatcgactt cgtggacgct ctcaagaccc 2460 tgtgccaccc cgtgctgcac gagcctgctc catgcctgca ggctttcacc gagcgtggtc 2520 ccccatccga gcccgctatg cagcgtctgc tggaatgccg tttccagcaa gagcccatgg 2580 gtggtgctgc tcgtcgtatc ccccacttct accgtgtgcg ccgcgaggtg ccccgtaccg 2640 tgaacgagat gaagcaggac ttcgtggtca ccgacttcta caaggttgga aacatcaccc 2700 tgtacaccga gctgcaccct ttcttcgact tcacccactg ccaagagaac tccgagactg 2760 tggctctgtg caccccccgt atcgtgatcg gcaacctgcc cgacggcctg gctcccggtc 2820 ccttccacga gctgaggacc tgggagatca tggaacacat gcgcctgcgt cccccacccg 2880 actacgagga aaccctgcgt ctgttcaaga ccaccgtgac ctcccccaac taccccgagc 2940 tgtgctacct ggtggacgtg ctggtgcacg gcaacgctga cgctttcctg ctgatccgcg 3000 ctttcatcgc tcgttgcatc gtgaacatgt tccacacccg tcagctgctg gtgttcgctc 3060 actcctacgc tctggtcacc ctgatcgctg agcacctggc tgacggtgct ctgccccccc 3120 agctcctgtt ccactaccgt aacctggtgg ctgtgctgcg cctggtcacc cgtatctccg 3180 ctctgcccgg cctgaacaac ggccagctgg ctgaggaacc cctgtccgct tacgtgaacg 3240 ctctgcacga ccacaggctg tggcccccct tcgtgaccca cctccctcgt aacatggaag 3300 gtgtccaggt ggtggctgat cgtcagcccc tgaaccccgc taacatcgag gctcgtcacc 3360 acggtgtctc cgacgtgccc cgtctgggtg ctatggacgc tgacgagccc ctgttcgtgg 3420 acgactaccg tgctaccgac gacgagtgga ccctgcaaaa ggtgttctac ctgtgcctga 3480 tccccgctat gaccaacaac cgtgcttgcg gcctgggcct gaacctcaag actctgctgg 3540 tggacctgtt ctaccgtccc gccttcctgc tcatgcccgc tgctaccgct gtgtccacct 3600 ccggcaccac ctccaaggaa tccacctctg gtgtcacccc cgaggactcc gtggctgctc 3660 agcgtcaggc tgtgggcgag atgctgaccg agctggtcga ggacgtggcc accgacgctc 3720 acacccctct gctgcaggct tgccgcgagc tgttcctggc tgtgcagttc gtgggcgagc 3780 acgtgaaggt gctggaagtg cgtgctcccc tggaccacgc tcagaggcag ggactgcccg 3840 acttcatctc ccgtcagcat gtgctgtaca acggttgctg cgtcgtgacc gctcctaaga 3900 ccctgatcga gtactccctg cccgtgccct tccaccgttt ctactccaac cccaccatct 3960 gcgctgctct gtccgacgac atcaagcgtt acgtgaccga gttcccccac taccatagac 4020 acgatggtgg tttccccctg cccaccgctt tcgctcacga gtaccacaac tggctgcgta 4080 gccccttctc ccgttactcc gctacctgcc ccaacgtgct gcactccgtg atgaccctgg 4140 ctgctatgct gtacaagatc tcccccgtgt ccctggtgct gcagaccaag gctcacatcc 4200 accccggttt cgctctgacc gctgtgcgta ccgacacctt cgaggtggac atgctgctgt 4260 actccggcaa gtcctgcacc tccgtcatca tcaacaaccc catcgtgacc aaggaagaga 4320 gggacatctc caccacctac cacgtgaccc agaacatcaa caccgtggac atgggcctgg 4380 gttacacctc caacacttgc gtggcctacg tgaaccgcgt ccgcaccgac atgggtgtcc 4440 gtgtgcagga cctgttccgt gtgttcccca tgaacgtgta ccgccacgat gaggtggacc 4500 gttggatcag gcacgctgct ggcgtcgagc gtccccagct gctggacacc gagactatct 4560 ccatgctgac cttcggttcc atgtccgagc gcaacgctgc tgctaccgtg cacggccaga 4620 aggctgtctg cgagctgatc ctgacccctg tgactatgga cgtgaactac ttcaagatca 4680 ccaacaaccc tcgtggtcgt gcttcctgca tgctgggcgt ggacccctac gacaccgagg 4740 ctgccaccaa ggctatctac gaccaccgcg aggctgacgc tcagaccttc gctgctaccc 4800 acaacccatg ggcttcccag gctggttgcc tgtccgacgt cctgtacaac acccgtcacc 4860 gcgagcgtct gggctacaac tccaagttct actccccctg cgctcagtac ttcaacaccg 4920 aggaaatcat cgctgccaac aagaccctct tcaagaccat cgacgagtac ctgctgcgcg 4980 ctaaggactg catccgtggc gacaccgaca ctcagtacgt gtgcgtcgag ggaaccgagc 5040 agctgatcga gaacccttgc cgtctgaccc aagaggctct gcccatcctg tccaccacca 5100 ccctggctct gatggaaact aagctgaagg gtggcgctgg tgctttcgct acctccgaga 5160 ctcacttcgg caactacgtc gtgggagaga tcatccccct gcagcagtcc atgctgttca 5220 acagctaaga gctcaagctt gtcgagaagt actagaggat cataatcagc cataccacat 5280 ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata 5340 aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa 5400 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 5460 tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt gagcctagaa 5520 gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgtggc tagctttgtt 5580 taactttaag aaggagatac atctagacct gcaggccgga atattaatag atcatggaga 5640 taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc gtaacagttt 5700 tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca tcgggcgcgg 5760 atcccggtcc gaagcgcgcg gaattcgcca ccatgaccat ggacgagcag cagccccagg 5820 ctgtgacccc cgtgtacgtg ggcggtttcc tggctcgtta cgaccagtcc cccgacgagg 5880 ctgagctgct gctgccacgt gacgtggtcg aacactggct gcacgctcag ggccagggac 5940 agccttccct gtccgtggct ctgcccctga acatcaacca cgacgacacc gctgtcgtgg 6000 gtcacgtggc cgctatgcag tccgtgcgtg acggcctgtt ctgcctgggt tgcgtgacct 6060 ccccccgttt cctggaaatc gtgcgtcgtg cttccgagaa gtccgagctg gtgtcccgtg 6120 gtcccgtgtc cccactgcag cccgacaagg tggtcgagtt cctgtccggt tcctacgctg 6180 gcctgtccct gtcatcccgt cgttgcgacg acgtcgaggc tgctacctcc ctgagcggct 6240 ccgagactac ccccttcaag cacgtggccc tgtgctccgt gggtcgtagg cgtggaaccc 6300 tggctgtgta cggtcgtgac cccgagtggg tcacccagcg tttccccgac ctgaccgctg 6360 ctgaccgtga cggactgcgt gctcagtggc agcgttgcgg ttccaccgct gtggacgctt 6420 ccggcgaccc cttccgttcc gactcctacg gcctgctggg caactccgtg gacgctctgt 6480 acatccgcga gcgtctgccc aagctgcgtt acgacaagca gctcgtgggt gtcaccgagc 6540 gcgagtccta cgtgaaggct tccgtgtccc ccgaggctgc ttgcgacatc aaggctgctt 6600 ccgctgagcg ttctggcgac agccgctccc aggctgctac tcctgctgct ggtgctcgtg 6660 tgccctccag ctccccatcc ccacctgtcg agcctccctc ccccgtgcaa cctcctgctc 6720 tgcctgcttc cccctccgtg ctgcctgctg agtccagccc ctccctgtca ccctctgagc 6780 ctgctgaggc tgcctccatg tcccaccctc tgagcgctgc tgtgactgct gctaccgctc 6840 cccctggtgc tactgtggct ggtgcttccc ccgctgtgcc ttccctggct tggcctcacg 6900 acggtgtcta cctgcccaag gacgctttct tctccctgct gggcgcttcc cgttccgctg 6960 ctcccgtgat gtaccccggt gctgtggctg ctccccccag cgcttcacct gctcctctgc 7020 ccctgccctc ctaccccgct tcctacggtg ctcccgtcgt gggttacgac cagctggctg 7080 ctcgtcactt cgctgactac gtggaccccc actaccccgg ctggggtcgt cgttacgagc 7140 ccgctccttc cctgcaccca tcctaccctg tgccccctcc tccatcaccc gcttactacc 7200 gtcgtcgtga ctcccccggt ggcatggacg agcctccatc tggatgggag cgttacgacg 7260 gttcccaccg tggccagtcc caaaagcagc accgtcacgg tggttccggt ggtcacaaca 7320 agcgtcgcaa ggaagccgct gctgcatcct ccagctccga cgaggacctg agcttccccg 7380 gcgaggctga acacggtcgt gctcgcaagc gtctgaagtc ccacgtgaac tccgacggag 7440 gtagcggagg ccacgctggt tccaaccagc agcagcaaca gcgctacgac gagctgcgtg 7500 acgctatcca cgagctgaag cgtgacctgt tcgctgctcg ccagtcctcc accctgctgt 7560 ctgctgctct gccagctgcc gcttcttcct cccctaccac caccaccgtg tgcaccccta 7620 ctggcgagct gacctctggt ggtggcgaga ctcccaccgc tctgctgtcc ggtggtgcta 7680 aggtggccga gcgtgctcag gctggtgtcg tgaacgcttc ctgccgtctg gctaccgctt 7740 ccggttccga ggctgccacc gctggtccct ctaccgctgg ttcctcatcc tgcccagctt 7800 ccgtggtgct ggctgccgct gctgctcaag ccgccgctgc ttcacagtcc cccccaaagg 7860 atatggtgga cctgaaccgt cgtatcttcg tggctgctct gaacaagctc gagtaataaa 7920 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 7980 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 8040 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 8100 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 8160 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 8220 aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact atcataaccc 8280 ctaggggcct ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatccgga 8340 tctgaacagg agggacagct gatagaaaca gaagccactg gagcacctca aaaacaccat 8400 catacactaa atcagtaagt tggcagcatc acccgacgca ctttgcgccg aataaatacc 8460 tgtgacggaa gatcacttcg cagaataaat aaatcctggt gtccctgttg ataccgggaa 8520 gccctgggcc aacttttggc gaaaatgaga cgttgatcgg cacgtaagag gttccaactt 8580 tcaccataat gaaataagat cactaccggg cgtatttttt gagttatcga gattttcagg 8640 agctaaggaa gctaaaatgg agaaaaaaat cactggatat accaccgttg atatatccca 8700 atggcatcgt aaagaacatt ttgaggcatt tcagtcagtt gctcaatgta cctataacca 8760 gaccgttcag ctggatatta cggccttttt aaagaccgta aagaaaaata agcacaagtt 8820 ttatccggcc tttattcaca ttcttgcccg cctgatgaat gctcatccgg aattccgtat 8880 ggcaatgaaa gacggtgagc tggtgatatg ggatagtgtt cacccttgtt acaccgtttt 8940 ccatgagcaa actgaaacgt tttcatcgct ctggagtgaa taccacgacg atttccggca 9000 gtttctacac atatattcgc aagatgtggc gtgttacggt gaaaacctgg cctatttccc 9060 taaagggttt attgagaata tgtttttcgt ctcagccaat ccctgggtga gtttcaccag 9120 ttttgattta aacgtggcca atatggacaa cttcttcgcc cccgttttca ccatgggcaa 9180 atattatacg caaggcgaca aggtgctgat gccgctggcg attcaggttc atcatgccgt 9240 ttgtgatggc ttccatgtcg gcagaatgct taatgaatta caacagtact gcgatgagtg 9300 gcagggcggg gcgtaatttt tttaaggcag ttattggtgc ccttaaacgc ctggttgcta 9360 cgcctgaata agtgataata agcggatgaa tggcagaaat tcgaaagcaa attcgacccg 9420 gtcgtcggtt cagggcaggg tcgttaaata gccgcttatg tctattgctg gtttaccggt 9480 ttattgacta ccggaagcag tgtgaccgtg tgcttctcaa atgcctgagg ccagtttgct 9540 caggctctcc ccgtggaggt aataattgac gatatgatca tttattctgc ctcccagctg 9600 acattcatcc ggggtcagca ccgtttctgc ggactggctt tctacgtgtt ccgcttcctt 9660 tagcagccct tgcgccctga gtgcttgcgg cagcgtgaag ct 9702 <210> 88 <211> 5016 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 88 aattctgtca gccgttaagt gttcctgtgt cactcaaaat tgctttgaga ggctctaagg 60 gcttctcagt gcgttacatc cctggcttgt tgtccacaac cgttaaacct taaaagcttt 120 aaaagcctta tatattcttt tttttcttat aaaacttaaa accttagagg ctatttaagt 180 tgctgattta tattaatttt attgttcaaa catgagagct tagtacgtga aacatgagag 240 cttagtacgt tagccatgag agcttagtac gttagccatg agggtttagt tcgttaaaca 300 tgagagctta gtacgttaaa catgagagct tagtacgtga aacatgagag cttagtacgt 360 actatcaaca ggttgaactg ctgatcaaca gatcctctac gcggccgcgg taccataact 420 tcgtatagca tacattatac gaagttatct ggtttaaacg tacccgtagt ggctatggca 480 gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt cacccgaact tgggggttgg 540 ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat ggggtctcgg tggggtatcg 600 acagagtgcc agccctggga ccgaaccccg cgtttatgaa caaacgaccc aacacccgtg 660 cgttttattc tgtcttttta ttgccgtcat agcgcgggtt ccttccggta ttgtctcctt 720 ccgtgtttca gttagcctcc cccatctccc ggtaccgcat gctatgcatc agctgctagc 780 accatggctc gagatcccgg gtgatcaagt cttcgtcgag tgattgtaaa taaaatgtaa 840 tttacagtat agtattttaa ttaatataca aatgatttga taataattct tatttaacta 900 taatatattg tgttgggttg aattaaaggt ccgtatacta gtatcgattc gcgacctact 960 ccggaatatt aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag 1020 tattttactg ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt 1080 cataccgtcc caccatcggg cgcggatccg ccaccatggc cccctcccac gtggacaagg 1140 tgaacacccg cacctggtcc gcctccatcg tgttcatggt gctgaccttc gtgaacgtgt 1200 ccgtgcacct ggtgctgtcc aacttccccc acctgggcta cccctgcgtg tactaccacg 1260 tggtggactt cgagcgcctg aacatgtccg cctacaacgt gatgcacctg cacaccccca 1320 tgctgttcct ggactccgtg cagctggtgt gctacgccgt gttcatgcag ctggtgttcc 1380 tggccgtgac catctactac ctggtgtgct ggatcaagat ctccatgcgc aaggacaagg 1440 gcatgtccct gaaccagtcc acccgcgaca tctcctacat gggcgactcc ctgaccgcct 1500 tcctgttcat cctgtccatg gacaccttcc agctgttcac cctgaccatg tccttccgcc 1560 tgccctccat gatcgccttc atggccgccg tgcacttctt ctgcctgacc atcttcaacg 1620 tgtccatggt gacccagtac cgctcctaca agcgctccct gttcttcttc tcccgcctgc 1680 accccaagct gaagggcacc gtgcagttcc gcaccctgat cgtgaacctg gtggaggtgg 1740 ccctgggctt caacaccacc gtggtggcca tggccctgtg ctacggcttc ggcaacaact 1800 tcttcgtgcg caccggccac atggtgctgg ccgtgttcgt ggtgtacgcc atcatctcca 1860 tcatctactt cctgctgatc gaggccgtgt tcttccagta cgtgaaggtg cagttcggct 1920 accacctggg cgccttcttc ggcctgtgcg gcctgatcta ccccatcgtg cagtacgaca 1980 ccttcctgtc caacgagtac cgcaccggca tctcctggtc cttcggcatg ctgttcttca 2040 tctgggccat gttcaccacc tgccgcgccg tgcgctactt ccgcggccgc ggctccggct 2100 ccgtgaagta ccaggccctg gccaccgcct ccggcgagga ggtggccgcc ctgtcccacc 2160 acgactccct ggagtcccgc cgcctgcgcg aggaggagga cgacgacgac gacgaggact 2220 tcgaggacgc ctaagagctc aagcttgtcg agaagtacta gaggatcata atcagccata 2280 ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga 2340 aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca 2400 aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt 2460 gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc 2520 ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc tgtggctagc 2580 tttgtttaac tttaagaagg agatacatct agaaatatta atagatcatg gagataatta 2640 aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca gttttgtaat 2700 aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc gcggatcccg 2760 gtccgaagcg cgcggaattc aaaggcctac gccaccatgg agtggaacac actagtacta 2820 ggtcttttgg ttttatcggt agcggcaagt tccaaccata cgtcgactgc tagcacaccg 2880 agtccctcta gctctactca cacctcaacg accgtgaagg caacgactac tgcgacaact 2940 agtacaacta cggtgacaag tacgacttca tcaacgacta gtaccaaacc cggttccacc 3000 actcacgacc ccaatgtgat gagaccacat gctcacaatg atttttacaa ggcgcattgt 3060 acatcgcata tgtatgaact ttctctgtcc agctttgcgg cctggtggac tatgcttaat 3120 gctctcattc tcatgggagc tttttgtatc gtactacgac attgctgttt ccagaacttt 3180 actgcaacca ccaccaaagg ctattgataa aagcttgtcg agaagtacta gagaagcttg 3240 tcgagaagta ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 3300 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 3360 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 3420 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 3480 cttatcatgt ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc 3540 cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactatcata acccctaggg 3600 gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc cggatctgaa 3660 caggagggac agctgataga aacagaagcc actggagcac ctcaaaaaca ccatcataca 3720 ctaaatcagt aagttggcag catcacccga cgcactttgc gccgaataaa tacctgtgac 3780 ggaagatcac ttcgcagaat aaataaatcc tggtgtccct gttgataccg ggaagccctg 3840 ggccaacttt tggcgaaaat gagacgttga tcggcacgta agaggttcca actttcacca 3900 taatgaaata agatcactac cgggcgtatt ttttgagtta tcgagatttt caggagctaa 3960 ggaagctaaa atggagaaaa aaatcactgg atataccacc gttgatatat cccaatggca 4020 tcgtaaagaa cattttgagg catttcagtc agttgctcaa tgtacctata accagaccgt 4080 tcagctggat attacggcct ttttaaagac cgtaaagaaa aataagcaca agttttatcc 4140 ggcctttatt cacattcttg cccgcctgat gaatgctcat ccggaattcc gtatggcaat 4200 gaaagacggt gagctggtga tatgggatag tgttcaccct tgttacaccg ttttccatga 4260 gcaaactgaa acgttttcat cgctctggag tgaataccac gacgatttcc ggcagtttct 4320 acacatatat tcgcaagatg tggcgtgtta cggtgaaaac ctggcctatt tccctaaagg 4380 gtttattgag aatatgtttt tcgtctcagc caatccctgg gtgagtttca ccagttttga 4440 tttaaacgtg gccaatatgg acaacttctt cgcccccgtt ttcaccatgg gcaaatatta 4500 tacgcaaggc gacaaggtgc tgatgccgct ggcgattcag gttcatcatg ccgtttgtga 4560 tggcttccat gtcggcagaa tgcttaatga attacaacag tactgcgatg agtggcaggg 4620 cggggcgtaa tttttttaag gcagttattg gtgcccttaa acgcctggtt gctacgcctg 4680 aataagtgat aataagcgga tgaatggcag aaattcgaaa gcaaattcga cccggtcgtc 4740 ggttcagggc agggtcgtta aatagccgct tatgtctatt gctggtttac cggtttattg 4800 actaccggaa gcagtgtgac cgtgtgcttc tcaaatgcct gaggccagtt tgctcaggct 4860 ctccccgtgg aggtaataat tgacgatatg atcatttatt ctgcctccca gctgacattc 4920 atccggggtc agcaccgttt ctgcggactg gctttctacg tgttccgctt cctttagcag 4980 cccttgcgcc ctgagtgctt gcggcagcgt gaagct 5016 <210> 89 <211> 6616 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 89 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtcgcgcc attcgccatt caggctgcgc aactgttggg 360 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 420 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 480 ccagtgcata gaccagccgc gtaacctggc aaaatcggtt acggttgagt aataaatgga 540 tgccctgcgt aagcgggtgt gggcggacaa taaagtctta aactgaacaa aatagatcta 600 aactatgaca ataaagtctt aaactagaca gaatagttgt aaactgaaat cagtccagtt 660 atgctgtgaa aaagcatact ggacttttgt tatggctaaa gcaaactctt cattttctga 720 agtgcaaatt gcccgtcgta ttaaagaggg gcgtggccaa gggcatggta aagactatat 780 tcgcggcgtt gtgacaattt accgaacaac tccgcggccg ggaagccgat ctcggcttga 840 acgaattgtt aggtggcggt acttgggtcg atatcaaagt gcatcacttc ttcccgtatg 900 cccaactttg tatagagagc cactgcggga tcgtcaccgt aatctgcttg cacgtagatc 960 acataagcac caagcgcgtt ggcctcatgc ttgaggagat tgatgagcgc ggtggcaatg 1020 ccctgcctcc ggtgctcgcc ggagactgcg agatcataga tatagatctc actacgcggc 1080 tgctcaaact tgggcagaac gtaagccgcg agagcgccaa caaccgcttc ttggtcgaag 1140 gcagcaagcg cgatgaatgt cttactacgg agcaagttcc cgaggtaatc ggagtccggc 1200 tgatgttggg agtaggtggc tacgtctccg aactcacgac cgaaaagatc aagagcagcc 1260 cgcatggatt tgacttggtc agggccgagc ctacatgtgc gaatgatgcc catacttgag 1320 ccacctaact ttgttttagg gcgactgccc tgctgcgtaa catcgttgct gctgcgtaac 1380 atcgttgctg ctccataaca tcaaacatcg acccacggcg taacgcgctt gctgcttgga 1440 tgcccgaggc atagactgta caaaaaaaca gtcataacaa gccatgaaaa ccgccactgc 1500 gccgttacca ccgctgcgtt cggtcaaggt tctggaccag ttgcgtgagc gcatacgcta 1560 cttgcattac agtttacgaa ccgaacaggc ttatgtcaac tgggttcgtg ccttcatccg 1620 tttccacggt gtgcgtcacc cggcaacctt gggcagcagc gaagtcgagg catttctgtc 1680 ctggctggcg aacgagcgca aggtttcggt ctccacgcat cgtcaggcat tggcggcctt 1740 gctgttcttc tacggcaagg tgctgtgcac ggatctgccc ttgcttcagg agatcggtag 1800 acctcggccg tcgcggcgct tgccggtggt gctgaccccg gatgaagtgg ttcgcatcct 1860 cggttttctg gaaggcgagc atcgtttgtt cgcccaggac tctagctata gttctagtgg 1920 ttggctacag ctttgtttgt actatcaaca ggttgaactg ctgatcaaca gatcctctac 1980 gcggccgcgg taccataact tcgtatagca tacattatac gaagttatct ggtttaaacg 2040 tacccgtagt ggctatggca gggcttgccg ccccgacgtt ggctgcgagc cctgggcctt 2100 cacccgaact tgggggttgg ggtggggaaa aggaagaaac gcgggcgtat tggtcccaat 2160 ggggtctcgg tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa 2220 caaacgaccc aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt 2280 ccttccggta ttgtctcctt ccgtgtttca gttagcctcc cccatctccc ggtaccgcat 2340 gctatgcatc agctgctagc accatggctc gagatcccgg gtgatcaagt cttcgtcgag 2400 tgattgtaaa taaaatgtaa tttacagtat agtattttaa ttaatataca aatgatttga 2460 taataattct tatttaacta taatatattg tgttgggttg aattaaaggt ccgtatacta 2520 gtatcgattc gcgacctact ccggaatatt aatagatcat ggagataatt aaaatgataa 2580 ccatctcgca aataaataag tattttactg ttttcgtaac agttttgtaa taaaaaaacc 2640 tataaatatt ccggattatt cataccgtcc caccatcggg cgcggatccc ggtccgaagc 2700 gcgcggaatt cgccaccatg ggccagaccg ttaccactcc cttgagtttg accctggatc 2760 actggaagga cgtcgagagg atcgctcaca accagtccgt agatgtcaag aagaggcgtt 2820 gggttacctt ctgcagtgcg gaatggccga cctttaacgt cggctggcct agagacggca 2880 ccttcaacag ggacctgatc acgcaggtga agatcaaagt gttctcacct ggccctcatg 2940 gacaccccga tcaagtcccc tacatcgtga cctgggaagc actggctttt gatccacctc 3000 cctgggccaa gcccttcgta caccctaaac ctccgcctcc acttcctcca tctgctccct 3060 ctctgccact tgaaccacct ctttcgacac cgagtcgcag ctccctttat cctgcactca 3120 ctccttctct gggcgccaag ccgaagcctc aagtactctc tgacagcgag ggtcccctga 3180 ttgacttgct gacggaagat cccccgcctt atagagaccc cagaccaccc ccttcagacg 3240 gtgacggaaa ttcgggagaa gcgactcctg ccggagaagc tccagacccc tcaccaatgg 3300 cctctcgctt gcgtggtaga cgcgaacccc ctgtggcgga ctccactacc tcgcaagcat 3360 tcccactgcg cacaggaggc aacggacagc tgcaatactg gccattctcc tcaagcgacc 3420 tctacaactg gaagaacaac aatcccagct tctcggagga ccctggtaaa ctgacagcgc 3480 tgatcgaatc cgtcctcatc acacatcagc ccacctggga cgactgtcaa cagctgttgg 3540 gaacgctgct taccggagaa gagaagcagc gcgtgctctt ggaggctaga aaagcggtga 3600 gaggcgatga tggacgcccg acacaactgc cgaacgaagt agatgccgct tttcccctgg 3660 aacgcccaga ctgggaatac actacccagg caggtaggaa ccacctcgtc caataccgcc 3720 aattgctcct ggctggtctc caaaacgctg gcagatcacc gaccaatttg gcgaaggtga 3780 agggaatcac gcagggacct aatgagtctc cgagcgcttt cctggagaga cttaaggagg 3840 cctaccgcag atacacaccc tacgaccctg aggacccagg acaagaaacg aacgtggcta 3900 tgtccttcat ttggcagtct gccccagaca ttggcagaaa gctggagagg ctggaagatc 3960 tcaagaacaa gacgctcgga gatctggtca gagaggctga gaggatcttc aacaagcgag 4020 agacaccgga ggaaagggag gaacgtatca ggcgagagac cgaggaaaag gaggaacgac 4080 gcaggacaga ggacgagcag aaagagaaag agcgcgaccg tagacgccat agggagatga 4140 gcaagctgct tgccactgtc gtgagtggac agagacagga tagacagggt ggcgaacgca 4200 ggagatccca actggataga gaccagtgtg cctactgcaa agagaaggga cactgggcta 4260 aagactgtcc caagaaacca cgaggacctc gtggaccaag accgcagact tccctcttga 4320 ctctggatga ccagctgttg aattttgacc ttcttaagct tgcgggagac gtcgagtcca 4380 accctgggcc catggaatcc cgtggtcgtc gttgccccga gatgatctcc gtgctgggtc 4440 ccatctccgg tcacgtcctg aaggctgtgt tctcccgtgg cgacaccccc gtgctgcccc 4500 acgaaactcg tctgctgcag accggtatcc acgtgcgtgt gtcccagccc tccctgatcc 4560 tggtgtccca gtacaccccc gactccaccc cttgccaccg cggagacaac cagctgcagg 4620 tccagcacac ctacttcacc ggttccgagg tcgagaacgt gtccgtgaac gtgcacaacc 4680 ccaccggtcg ttccatctgc ccctcccaag agcccatgtc catctacgtg tacgctctgc 4740 ccctgaagat gctgaacatc ccctccatca acgtgcacca ctacccctcc gctgctgagc 4800 gcaagcaccg tcacctcccc gtggctgacg ctgtgatcca cgcttccggc aagcagatgt 4860 ggcaggctcg tctgaccgtg tccggcctgg cttggacccg tcagcagaac cagtggaagg 4920 aacccgacgt gtactacacc tccgctttcg tgttccccac caaggacgtg gccctgcgtc 4980 acgtcgtgtg cgctcacgaa ctcgtgtgct ccatggaaaa cacccgtgct accaagatgc 5040 aagtgatcgg cgaccagtac gtgaaggtgt acctggaatc cttctgcgag gacgtgccct 5100 ccggcaagct gttcatgcac gtgaccctgg gttccgacgt ggaagaggac ctgaccatga 5160 cccgtaaccc ccagcccttc atgcgtcccc acgagcgtaa cggtttcacc gtgctgtgcc 5220 ccaagaacat gatcatcaag cccggcaaga tctcccacat catgctggac gtggccttca 5280 cctcccacga gcacttcggc ctgctgtgcc ctaagtccat ccccggcctg tccatctccg 5340 gcaacctgct gatgaacggc cagcagatct tcctggaagt gcaggctatc cgtgaaaccg 5400 tcgagctgcg tcagtacgac cctgtggctg ctctgttctt cttcgacatc gacctgctgc 5460 tgcagcgtgg tccccagtac tccgagcacc ccaccttcac cagccagtac cgtatccagg 5520 gcaagctgga ataccgtcac acctgggacc gtcacgacga gggtgctgct cagggcgacg 5580 acgacgtgtg gacctccggt tccgactccg acgaggaact ggtcaccacc gagcgcaaga 5640 ccccccgtgt gaccggtggt ggtgctatgg ctggtgcttc cacctccgct ggtcgcaagc 5700 gcaagtccgc ttcctccgct accgcttgca ccgctggtgt catgacccgt ggtcgcctga 5760 aggctgagtc caccgtggct cccgaagagg acactgacga ggactccgac aacgagatcc 5820 acaaccccgc tgtgttcacc tggcccccct ggcaggctgg tatcctggct cgtaacctgg 5880 tgcccatggt ggctaccgtg cagggccaga acctgaagta ccaagagttc ttctgggacg 5940 ccaacgacat ctaccgtatc ttcgctgagc tggaaggcgt gtggcagccc gctgctcagc 6000 ccaagcgtcg tcgtcaccgt caggacgctc tgcctggtcc ctgtatcgct tccaccccca 6060 agaagcaccg cggctaaaag cttgtcgaga agtactagag gatcataatc agccatacca 6120 catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac 6180 ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat 6240 aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg 6300 gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta 6360 gaagatccgg ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag 6420 caataactat cataacccct aggagatccg aaccagataa gtgaaatcta gttccaaact 6480 attttgtcat ttttaatttt cgtattagct tacgacgcta cacccagttc ccatctattt 6540 tgtcactctt ccctaaataa tccttaaaaa ctccatttcc acccctccca gttcccaact 6600 attttgtccg cccaca 6616 <210> 90 <211> 25535 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 90 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcttac tgcagccacc accacaggga gttcagggtg gacaggttca 2400 cagcacgacg gtgctcaggg ggggtcaggt tgccgtaggt ggaggactgc aggctgaagt 2460 tacggatctc agacaggaac agcagggagt ccaggtagtc ccacatgggg tcgatgaagg 2520 tgcgctggaa acgggtggat ggggaggtgg gggtggtctt gttgttgtcg gaagcagtct 2580 cgttctcgac gggcatggtg tcgttgtagt acagggagga catgtccagg gtgccgtaga 2640 tggtgtaggg agtctcgtta cggatcagca cgtgagtgtt cttcatgaac tcggacacag 2700 cggtacggtt acggttgggc ttgcagaagg gctcgtcacg gtaacgcagg gtggtgtaca 2760 cccaggtagc caggtccttc agctgagtgg tcaggataga cttcatgaag ttctcgtcgg 2820 gacggtaacc gatggtagag gtggggatac gggtgggcac gatgggggag taggtcacgt 2880 tggtggaaac gttgaagatg gtggaggtgt aggaggagta gggggtagta gtgctgacgc 2940 gggacttctt ggagatggac ttcacgggag cctgcttgcg cttcagcttg cgcatggtgt 3000 tcttcagctt ggtggagttg atgtacttgg gcacacggaa gatgttacgg gacatagcgt 3060 tgaccaggta gaaggaacgg gtgcagttgc gctgagcgta acgcagcagc agagcagcca 3120 ggcccaggaa gtagatagtc tgggagtcca cgttgacctt ggaggggccc acgtacagct 3180 tggtgttcca acggggcacg ttgaagaaca tggggttgaa ggtggtgaag ttgccgcagt 3240 tttcctcgcc ggtgttgtta cgacgggaca cgttcagcat ctcggacagg caggtcatgg 3300 aggggatggt gccgcaagag gggggacgga aggtgatctt ctggccggtg tggttgtact 3360 cggagtacac gtacttagcg ggcttgcgca gctgggtggt gtggaagtcg aaccacaggt 3420 gggtgatgga gtggttacgg atgggaccag ccaggatgga gttggggggg aactgcttca 3480 tctcgacggt gatgttgtac agcttctgct ggctggggaa ggtgaagaac ttgtagtagt 3540 cgccggtctt ggaagccagc tcttgcagga tacgcagctt cagctggcgt tcctcttcct 3600 tagccttctg ggacttcaca cggaaacgag ccacagcgat cttgcagttg atgaagctga 3660 acagcaggaa ggtcagggac atcaggaaga acaggttgaa cacgccacgc atctcgccct 3720 tgcgacccat ggtggcctcg agatcccggg tgatcaagtc ttcgtcgagt gattgtaaat 3780 aaaatgtaat ttacagtata gtattttaat taatatacaa atgatttgat aataattctt 3840 atttaactat aatatattgt gttgggttga attaaaggtc cgtatactag tatcgattcg 3900 cgacctactc cggaatatta atagatcatg gagataatta aaatgataac catctcgcaa 3960 ataaataagt attttactgt tttcgtaaca gttttgtaat aaaaaaacct ataaatattc 4020 cggattattc ataccgtccc accatcgggc gcggatccgc caccatggaa aactggtccg 4080 ctctggaact gctgcccaag gtcggaatcc ctaccgactt cctgacccac gtcaagacct 4140 ccgctggcga ggaaatgttc gaggctctga ggatctacta cggcgacgac cccgagcgtt 4200 acaacatcca cttcgaggct atcttcggca ccttctgcaa ccgtctggaa tgggtgtact 4260 tcctgacttc cggcctggct gctgctgctc acgctatcaa gttccacgac ctgaacaagc 4320 tgaccaccgg caagatgctg ttccacgtgc aagtgccccg tgtggcttcc ggtgctggcc 4380 tgcctacctc ccgtcagacc accatcatgg tcaccaagta ctccgagaag tcccccatca 4440 ccatcccttt cgagctgtcc gctgcttgcc tgacttacct gcgtgaaacc ttcgagggca 4500 ccatcctgga caagatcctg aacgtcgagg ctatgcacac cgtgctgcgt gctctgaaga 4560 acaccgctga cgctatggaa cgtggcctga tccacagctt cctccagacc ctgctgagga 4620 aggctccccc ctacttcgtg gtgcagaccc tggtcgagaa cgctaccctg gctcgtcagg 4680 ctctgaaccg tatccagcgc tccaacatcc tgcagtcctt caaggctaag atgctggcta 4740 ccctgttcct gctgaaccgt acccgtgacc gtgactacgt gctgaagttc ctgacccgtc 4800 tggctgaggc tgctaccgac tccatcctcg acaaccctac tacctacacc acctcctccg 4860 gtgctaagat ctccggtgtc atggtgtcca ccgctaacgt gatgcagatc atcatgtccc 4920 tgctgtcctc ccacatcact aaggaaaccg tgtccgctcc cgctacctac ggcaacttcg 4980 tgctgtcccc cgagaacgct gtgaccgcta tctcctacca ctctatcctg gctgacttca 5040 actcctacaa ggctcacctg acctccggcc agccccacct ccccaacgac tccctgagcc 5100 aggctggtgc tcactccctg acccccctgt ccatggacgt gatccgtctg ggcgaaaaga 5160 ccgtgatcat ggaaaacctg cgtcgcgtgt acaagaacac cgacaccaag gaccccctgg 5220 aacgtaacgt ggacctgacc ttcttcttcc ccgtgggcct gtacctgccc gaggaccgtg 5280 gttacaccac cgtcgagtcc aaggtcaagc tgaacgacac cgtgcgtaac gctctgccca 5340 ccaccgctta cctgctgaac agggaccgtg ctgtgcaaaa gatcgacttc gtggacgctc 5400 tcaagaccct gtgccacccc gtgctgcacg agcctgctcc atgcctgcag gctttcaccg 5460 agcgtggtcc cccatccgag cccgctatgc agcgtctgct ggaatgccgt ttccagcaag 5520 agcccatggg tggtgctgct cgtcgtatcc cccacttcta ccgtgtgcgc cgcgaggtgc 5580 cccgtaccgt gaacgagatg aagcaggact tcgtggtcac cgacttctac aaggttggaa 5640 acatcaccct gtacaccgag ctgcaccctt tcttcgactt cacccactgc caagagaact 5700 ccgagactgt ggctctgtgc accccccgta tcgtgatcgg caacctgccc gacggcctgg 5760 ctcccggtcc cttccacgag ctgaggacct gggagatcat ggaacacatg cgcctgcgtc 5820 ccccacccga ctacgaggaa accctgcgtc tgttcaagac caccgtgacc tcccccaact 5880 accccgagct gtgctacctg gtggacgtgc tggtgcacgg caacgctgac gctttcctgc 5940 tgatccgcgc tttcatcgct cgttgcatcg tgaacatgtt ccacacccgt cagctgctgg 6000 tgttcgctca ctcctacgct ctggtcaccc tgatcgctga gcacctggct gacggtgctc 6060 tgccccccca gctcctgttc cactaccgta acctggtggc tgtgctgcgc ctggtcaccc 6120 gtatctccgc tctgcccggc ctgaacaacg gccagctggc tgaggaaccc ctgtccgctt 6180 acgtgaacgc tctgcacgac cacaggctgt ggcccccctt cgtgacccac ctccctcgta 6240 acatggaagg tgtccaggtg gtggctgatc gtcagcccct gaaccccgct aacatcgagg 6300 ctcgtcacca cggtgtctcc gacgtgcccc gtctgggtgc tatggacgct gacgagcccc 6360 tgttcgtgga cgactaccgt gctaccgacg acgagtggac cctgcaaaag gtgttctacc 6420 tgtgcctgat ccccgctatg accaacaacc gtgcttgcgg cctgggcctg aacctcaaga 6480 ctctgctggt ggacctgttc taccgtcccg ccttcctgct catgcccgct gctaccgctg 6540 tgtccacctc cggcaccacc tccaaggaat ccacctctgg tgtcaccccc gaggactccg 6600 tggctgctca gcgtcaggct gtgggcgaga tgctgaccga gctggtcgag gacgtggcca 6660 ccgacgctca cacccctctg ctgcaggctt gccgcgagct gttcctggct gtgcagttcg 6720 tgggcgagca cgtgaaggtg ctggaagtgc gtgctcccct ggaccacgct cagaggcagg 6780 gactgcccga cttcatctcc cgtcagcatg tgctgtacaa cggttgctgc gtcgtgaccg 6840 ctcctaagac cctgatcgag tactccctgc ccgtgccctt ccaccgtttc tactccaacc 6900 ccaccatctg cgctgctctg tccgacgaca tcaagcgtta cgtgaccgag ttcccccact 6960 accatagaca cgatggtggt ttccccctgc ccaccgcttt cgctcacgag taccacaact 7020 ggctgcgtag ccccttctcc cgttactccg ctacctgccc caacgtgctg cactccgtga 7080 tgaccctggc tgctatgctg tacaagatct cccccgtgtc cctggtgctg cagaccaagg 7140 ctcacatcca ccccggtttc gctctgaccg ctgtgcgtac cgacaccttc gaggtggaca 7200 tgctgctgta ctccggcaag tcctgcacct ccgtcatcat caacaacccc atcgtgacca 7260 aggaagagag ggacatctcc accacctacc acgtgaccca gaacatcaac accgtggaca 7320 tgggcctggg ttacacctcc aacacttgcg tggcctacgt gaaccgcgtc cgcaccgaca 7380 tgggtgtccg tgtgcaggac ctgttccgtg tgttccccat gaacgtgtac cgccacgatg 7440 aggtggaccg ttggatcagg cacgctgctg gcgtcgagcg tccccagctg ctggacaccg 7500 agactatctc catgctgacc ttcggttcca tgtccgagcg caacgctgct gctaccgtgc 7560 acggccagaa ggctgtctgc gagctgatcc tgacccctgt gactatggac gtgaactact 7620 tcaagatcac caacaaccct cgtggtcgtg cttcctgcat gctgggcgtg gacccctacg 7680 acaccgaggc tgccaccaag gctatctacg accaccgcga ggctgacgct cagaccttcg 7740 ctgctaccca caacccatgg gcttcccagg ctggttgcct gtccgacgtc ctgtacaaca 7800 cccgtcaccg cgagcgtctg ggctacaact ccaagttcta ctccccctgc gctcagtact 7860 tcaacaccga ggaaatcatc gctgccaaca agaccctctt caagaccatc gacgagtacc 7920 tgctgcgcgc taaggactgc atccgtggcg acaccgacac tcagtacgtg tgcgtcgagg 7980 gaaccgagca gctgatcgag aacccttgcc gtctgaccca agaggctctg cccatcctgt 8040 ccaccaccac cctggctctg atggaaacta agctgaaggg tggcgctggt gctttcgcta 8100 cctccgagac tcacttcggc aactacgtcg tgggagagat catccccctg cagcagtcca 8160 tgctgttcaa cagctaagag ctcaagcttg tcgagaagta ctagaggatc ataatcagcc 8220 ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc 8280 tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt 8340 acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta 8400 gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctga tcactgcttg 8460 agcctagaag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgtggct 8520 agctttgttt aactttaaga aggagataca tctagaaata ttaatagatc atggagataa 8580 ttaaaatgat aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt 8640 aataaaaaaa cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc 8700 cgccaccatg gctgctatgg aagctaacat cttctgcacc ttcgaccaca agctgtctat 8760 cgctgacgtg ggcaagctga ccaagctggt ggctgctgtg gtgcccatcc cccagcgtct 8820 gcacctgatc aagcactacc agctgggcct gcaccagttc gtggaccaca cccgtggtta 8880 cgtgcgtctg cgtggcctgc tgcgtaacat gaccctgacc ctgatgcgtc gtgtcgaggg 8940 caaccagatc ctgctgcacg tgcccaccca cggcctgctg tacaccgtgc tgaacaccgg 9000 tcccgtgacc tgggagaagg gcgacgctct gtgcgtgctg ccccccctgt tccacggtcc 9060 cctggctcgt gaaaacctgt tgaccctggg ccagtgggag ctggtgctgc cctggatcgt 9120 gcccatgccc ctggctctgg aaatcaacca gcgcctgctg atcatgggcc tgttctccct 9180 ggaccgttcc tacgaagaag tgaaggctgc tgtccagcag ctgcagacca tcaccttccg 9240 tgacgctacc ttcaccatcc ccgaccccgt gatcgaccag cacctcctga tcgacatgaa 9300 gaccgcttgc ctgtccatgt ccatggtggc taacctggct tccgagctga ccatgaccta 9360 cgtccgcaag ctggctttgg aggactcttc catgctgctg gtcaagtgcc aagagctgct 9420 gatgcgtctg gaccgcgagc gttccgtggg cgagcctcgt actcccgctc gtcctcagca 9480 cgtgtccccc gacgacgaga tcgctcgtct gtccgctctg ttcgtgatgc tgcgtcagct 9540 ggacgacctg atccgcgagc aggtcgtgtt caccgtgtgc gacgtgagcc cagacaacaa 9600 gtccgctacc tgcatcttca agggctaagg cgcgccaagc ttgtcgagaa gtactagagg 9660 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 9720 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 9780 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 9840 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 9900 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 9960 ggctgctggg tgcctaatga gtgagctaac tcacattaat tgcccggaat attaatagat 10020 catggagata attaaaatga taaccatctc gcaaataaat aagtatttta ctgttttcgt 10080 aacagttttg taataaaaaa acctataaat attccggatt attcataccg tcccaccatc 10140 gggcgcggat cccggtccga agcgcgcgga attcaaaggc ctacgtcgac gccaccatgt 10200 ccaacaccgc tcccggtccc accgtggcta acaagcgtga cgagaagcac cgtcacgtgg 10260 tcaacgtggt gctcgagctg cccaccgaga tctccgaggc tacccacccc gtgctggcta 10320 ccatgctgtc caagtacacc cgtatgtcct ccctgttcaa cgacaagtgc gctttcaagc 10380 tggacctgct gcgtatggtg gctgtgtccc gtacccgtcg ctaaaagctt gtcgagaagt 10440 actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc 10500 tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt 10560 ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag 10620 catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg 10680 tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa 10740 gctgagttgg ctgctgggtg cctaatgagt gagctaactc acattaattg cccggaatat 10800 taatagatca tggagataat taaaatgata accatctcgc aaataaataa gtattttact 10860 gttttcgtaa cagttttgta ataaaaaaac ctataaatat tccggattat tcataccgtc 10920 ccaccatcgg gcgcggatcc cggtccgaag cgcgcggaat tcaaaggcct acgtcgacgc 10980 caccatggaa tcccgtggtc gtcgttgccc cgagatgatc tccgtgctgg gtcccatctc 11040 cggtcacgtc ctgaaggctg tgttctcccg tggcgacacc cccgtgctgc cccacgaaac 11100 tcgtctgctg cagaccggta tccacgtgcg tgtgtcccag ccctccctga tcctggtgtc 11160 ccagtacacc cccgactcca ccccttgcca ccgcggagac aaccagctgc aggtccagca 11220 cacctacttc accggttccg aggtcgagaa cgtgtccgtg aacgtgcaca accccaccgg 11280 tcgttccatc tgcccctccc aagagcccat gtccatctac gtgtacgctc tgcccctgaa 11340 gatgctgaac atcccctcca tcaacgtgca ccactacccc tccgctgctg agcgcaagca 11400 ccgtcacctc cccgtggctg acgctgtgat ccacgcttcc ggcaagcaga tgtggcaggc 11460 tcgtctgacc gtgtccggcc tggcttggac ccgtcagcag aaccagtgga aggaacccga 11520 cgtgtactac acctccgctt tcgtgttccc caccaaggac gtggccctgc gtcacgtcgt 11580 gtgcgctcac gaactcgtgt gctccatgga aaacacccgt gctaccaaga tgcaagtgat 11640 cggcgaccag tacgtgaagg tgtacctgga atccttctgc gaggacgtgc cctccggcaa 11700 gctgttcatg cacgtgaccc tgggttccga cgtggaagag gacctgacca tgacccgtaa 11760 cccccagccc ttcatgcgtc cccacgagcg taacggtttc accgtgctgt gccccaagaa 11820 catgatcatc aagcccggca agatctccca catcatgctg gacgtggcct tcacctccca 11880 cgagcacttc ggcctgctgt gccctaagtc catccccggc ctgtccatct ccggcaacct 11940 gctgatgaac ggccagcaga tcttcctgga agtgcaggct atccgtgaaa ccgtcgagct 12000 gcgtcagtac gaccctgtgg ctgctctgtt cttcttcgac atcgacctgc tgctgcagcg 12060 tggtccccag tactccgagc accccacctt caccagccag taccgtatcc agggcaagct 12120 ggaataccgt cacacctggg accgtcacga cgagggtgct gctcagggcg acgacgacgt 12180 gtggacctcc ggttccgact ccgacgagga actggtcacc accgagcgca agaccccccg 12240 tgtgaccggt ggtggtgcta tggctggtgc ttccacctcc gctggtcgca agcgcaagtc 12300 cgcttcctcc gctaccgctt gcaccgctgg tgtcatgacc cgtggtcgcc tgaaggctga 12360 gtccaccgtg gctcccgaag aggacactga cgaggactcc gacaacgaga tccacaaccc 12420 cgctgtgttc acctggcccc cctggcaggc tggtatcctg gctcgtaacc tggtgcccat 12480 ggtggctacc gtgcagggcc agaacctgaa gtaccaagag ttcttctggg acgccaacga 12540 catctaccgt atcttcgctg agctggaagg cgtgtggcag cccgctgctc agcccaagcg 12600 tcgtcgtcac cgtcaggacg ctctgcctgg tccctgtatc gcttccaccc ccaagaagca 12660 ccgcggctaa aagcttgtcg agaagtacta gaggatcata atcagccata ccacatttgt 12720 agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 12780 gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 12840 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 12900 caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctagaagatc 12960 cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct gagcaataac 13020 tatcataacc cctaggggcc tctaaacggg tcttgagggg ttttttgctg aaaggaggaa 13080 ctatatccgg atctgaacag gagggacagc tgatagaaac agaagccact ggagcacctc 13140 aaaaacacca tcatacacta aatcagtaag ttggcagcat cacccgacgc actttgcgcc 13200 gaataaatac ctgtgacgga agatcacttc gcagaataaa taaatcctgg tgtccctgtt 13260 gataccggga agccctgggc caacttttgg cgaaaatgag acgttgatcg gcacgtaaga 13320 ggttccaact ttcaccataa tgaaataaga tcactaccgg gcgtattttt tgagttatcg 13380 agattttcag gagctaagga agctaaaatg gagaaaaaaa tcactggata taccaccgtt 13440 gatatatccc aatggcatcg taaagaacat tttgaggcat ttcagtcagt tgctcaatgt 13500 acctataacc agaccgttca gctggatatt acggcctttt taaagaccgt aaagaaaaat 13560 aagcacaagt tttatccggc ctttattcac attcttgccc gcctgatgaa tgctcatccg 13620 gaattccgta tggcaatgaa agacggtgag ctggtgatat gggatagtgt tcacccttgt 13680 tacaccgttt tccatgagca aactgaaacg ttttcatcgc tctggagtga ataccacgac 13740 gatttccggc agtttctaca catatattcg caagatgtgg cgtgttacgg tgaaaacctg 13800 gcctatttcc ctaaagggtt tattgagaat atgtttttcg tctcagccaa tccctgggtg 13860 agtttcacca gttttgattt aaacgtggcc aatatggaca acttcttcgc ccccgttttc 13920 accatgggca aatattatac gcaaggcgac aaggtgctga tgccgctggc gattcaggtt 13980 catcatgccg tttgtgatgg cttccatgtc ggcagaatgc ttaatgaatt acaacagtac 14040 tgcgatgagt ggcagggcgg ggcgtaattt ttttaaggca gttattggtg cccttaaacg 14100 cctggttgct acgcctgaat aagtgataat aagcggatga atggcagaaa ttcgaaagca 14160 aattcgaccc ggtcgtcggt tcagggcagg gtcgttaaat agccgcttat gtctattgct 14220 ggtttaccgg tttattgact accggaagca gtgtgaccgt gtgcttctca aatgcctgag 14280 gccagtttgc tcaggctctc cccgtggagg taataattga cgatatgatc atttattctg 14340 cctcccagct gacattcatc cggggtcagc accgtttctg cggactggct ttctacgtgt 14400 tccgcttcct ttagcagccc ttgcgccctg agtgcttgcg gcagcgtgaa gctaattctg 14460 tcagccgtta agtgttcctg tgtcactcaa aattgctttg agaggctcta agggcttctc 14520 agtgcgttac atccctggct tgttgtccac aaccgttaaa ccttaaaagc tttaaaagcc 14580 ttatatattc ttttttttct tataaaactt aaaaccttag aggctattta agttgctgat 14640 ttatattaat tttattgttc aaacatgaga gcttagtacg tgaaacatga gagcttagta 14700 cgttagccat gagagcttag tacgttagcc atgagggttt agttcgttaa acatgagagc 14760 ttagtacgtt aaacatgaga gcttagtacg tgaaacatga gagcttagta cgtactatca 14820 acaggttgaa ctgctgatca acagatcctc tacgcggccg cggtaccata acttcgtata 14880 gcatacatta tacgaagtta tctggtttaa acgtacccgt agtggctatg gcagggcttg 14940 ccgccccgac gttggctgcg agccctgggc cttcacccga acttgggggt tggggtgggg 15000 aaaaggaaga aacgcgggcg tattggtccc aatggggtct cggtggggta tcgacagagt 15060 gccagccctg ggaccgaacc ccgcgtttat gaacaaacga cccaacaccc gtgcgtttta 15120 ttctgtcttt ttattgccgt catagcgcgg gttccttccg gtattgtctc cttccgtgtt 15180 tcagttagcc tcccccatct cccggtaccg catgctatgc atcagctgct agcttagcga 15240 gcgtccacag cctggggacc gtaacgggag tgagcgggca ggttcacacg ggtctgcttc 15300 agctcagggg gcaggccagc gtagtacttg tccaggtgac gcagcagggg ggggtccagc 15360 tggtgacgca ggcagaattc cttcacagcg ttgtacaggc cgtagaacag ggtgataccc 15420 tcgggagcag cagcggtgga cacgggcaga cgcacagcac ggttggtacg ggtagcctcg 15480 ttacggatag ccaccaccac gttgaacagg gaggggggca ccagctcgaa acccagcacg 15540 tgttcggtga agatggaacg accgtaggac agacgagtca ggtcgtaacc acggcacagg 15600 tcgtccacgc aagtgtacac agcgggggaa ccgtcgccgc actcggagta accgcgcatc 15660 acggtcatcc aacggggagc ggtgtcggag gacagcaggg tcagcagagc acgcagctgg 15720 tcggggttgt tgtacagcag ggccagggtg tccaggaaag cgtcgtccag cagcacggag 15780 ttagcagcct cgggggtcac gggacggtaa cggatcagct gggacagggg accgtcccta 15840 cgggtcacgt tgaccagggg acgcagccag gactcgtact tgtcgccctg gaacacctct 15900 cccagcaggc aacgacgggt cagctcgggg cactcagcgg gcaccttctc agccacggtg 15960 ggagccacgg acacggtagc ggaggacacg atgggcagca gcaggcagca ccacagcaga 16020 gccacgggac cgggggagaa ggagaaaccg cagtcgggac gacggcacat ggtggctcga 16080 gatcccgggt gatcaagtct tcgtcgagtg attgtaaata aaatgtaatt tacagtatag 16140 tattttaatt aatatacaaa tgatttgata ataattctta tttaactata atatattgtg 16200 ttgggttgaa ttaaaggtcc gtatactagt atcgattcgc gacctactcc ggaatattaa 16260 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 16320 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 16380 ccatcgggcg cggatccgcc accatgtccc ccaagaacct gacccccttc ctgaccgctc 16440 tgtggctgct gctgggccac tcccgtgtgc ctcgtgtgcg tgctgaggaa tgctgcgagt 16500 tcatcaacgt gaaccacccc cccgagcgct gctacgactt caagatgtgc aaccgtttca 16560 ccgtggctct gcgttgcccc gacggcgaag tgtgctactc ccccgaaaag accgctgaga 16620 tccgtggtat cgtgaccacc atgacccact ccctgacccg tcaggtggtg cacaacaagc 16680 tgacctcttg caactacaac cccctgtacc tcgaggctga cggtcgtatc cgttgcggca 16740 aggtcaacga caaggctcag tacctgctgg gtgctgctgg ttccgtgccc taccgttgga 16800 tcaacctcga gtacgacaag atcacccgta tcgtgggcct ggaccagtac ctcgagtccg 16860 tgaagaagca caagcgtctg gacgtgtgcc gtgctaagat gggttacatg ctgcagtaaa 16920 agcttgtcga gaagtactag aggatcataa tcagccatac cacatttgta gaggttttac 16980 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 17040 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 17100 atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 17160 atgtatctta tcatgtctgg atctgatcac tgcttgagcc tagaagatcc ggctgctaac 17220 aaagcccgaa aggaagctga gttggctgct gtggctagct ttgtttaact ttaagaagga 17280 gatacatcta gaccggaata ttaatagatc atggagataa ttaaaatgat aaccatctcg 17340 caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa cctataaata 17400 ttccggatta ttcataccgt cccaccatcg ggcgcggatc cgccaccatg ctgcgtctgc 17460 tgctgcgtca ccacttccac tgcctgctgc tgtgcgctgt gtgggctacc ccctgcctgg 17520 cttccccttg gtccaccctg accgctaacc agaacccctc cccaccctgg tccaagctga 17580 cctactccaa gccccacgac gctgctacct tctactgccc cttcctgtac ccatcccccc 17640 ctcgttcccc actgcagttc tccggtttcc agcgtgtgct gaccggtccc gagtgccgta 17700 acgagactct gtacctgctg tacaaccgcg agggccagac cctggtcgag aggtcctcca 17760 cctgggtcaa gaaggtcatc tggtacttgt ccggtcgtaa ccagaccatc ctgcagcgta 17820 tgccccgtac cgcttccaag ccctccgacg gcaacgtgca gatctccgtc gaggacgcta 17880 agatcttcgg tgctcacatg gtgcccaagc agaccaagct gctgcgtttc gtggtcaacg 17940 acggcacccg ttaccagatg tgcgtgatga agctcgagtc ctgggctcac gtgttccgtg 18000 actactccgt gtccttccaa gtgcgcctga ccttcaccga ggctaacaac cagacctaca 18060 ccttctgcac ccaccccaac ctgatcgtgt aaaagcttgt cgagaagtac tagaggatca 18120 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 18180 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 18240 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 18300 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctgat 18360 cactgcttga gcctagaaga tccggctgct aacaaagccc gaaaggaagc tgagttggct 18420 gctgggtgcc taatgagtga gctaactcac attaattgcc cggaatatta atagatcatg 18480 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 18540 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 18600 gcggatccgc caccatgcgt ctgtgccgtg tgtggctgtc cgtgtgcctg tgcgctgtgg 18660 tgctgggcca gtgccagcgt gaaaccgctg agaagaacga ctactaccgt gtgccccact 18720 actgggacgc ttgctcccgt gctctgcccg accagacccg ttacaagtac gtcgagcagc 18780 tggtggacct gaccctgaac taccactacg acgcttccca cggcctggac aacttcgacg 18840 tgctgaagcg tatcaacgtg accgaggtgt ccctgctgat ctccgacttc cgtcgtcaga 18900 accgtcgtgg tggcaccaac aagcgtacca ccttcaacgc tgctggttcc ctggctcccc 18960 acgctcgttc cctcgagttc tccgtgcgtc tgttcgctaa ctaaaagctt gtcgagaagt 19020 actagaggat cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc 19080 tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt 19140 ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag 19200 catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg 19260 tctggatctg atcactgctt gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa 19320 gctgagttgg ctgctgccac cgctgagcaa taactatcat aacccccgga atattaatag 19380 atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt tactgttttc 19440 gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac cgtcccacca 19500 tcgggcgcgg atcccggtcc gaagcgcgcg gaattcaaag gcctaccgtc gacgccacca 19560 tggaatcccg tatctggtgc ctggtcgtgt gcgtgaacct gtgcatcgtg tgcctgggtg 19620 ctgctgtgtc ctcctcctcc acccgtggca cctccgctac ccactcccac cactcctccc 19680 acaccacctc cgccgctcac tcccgttccg gttccgtgtc ccagcgtgtg acctcctccc 19740 agaccgtgtc ccacggtgtc aacgagacta tctacaacac caccctgaag tacggcgacg 19800 tcgtgggtgt caacaccacc aagtacccct accgtgtgtg ctccatggct cagggcaccg 19860 acctgatccg tttcgagcgt aacatcgtgt gcacctccat gaagcccatc aacgaggacc 19920 tggacgaggg tatcatggtg gtgtacaagc gcaacatcgt ggctcacacc ttcaaggtcc 19980 gcgtgtacca gaaggtgctg accttccgtc gttcctacgc ttacatccac accacttacc 20040 tgctgggttc caacaccgag tacgtggccc ctcccatgtg ggagatccac cacatcaact 20100 cccactccca gtgctactcc tcttactccc gtgtgatcgc tggcaccgtg ttcgtggctt 20160 accaccgtga ctcctacgag aacaagacca tgcagctgat gcccgacgac tactccaaca 20220 cccactccac ccgttacgtg accgtgaagg accagtggca ctcccgtggt tccacctggc 20280 tgtaccgtga aacctgcaac ctgaactgca tggtcaccat caccaccgct cgttccaagt 20340 acccttacca cttcttcgct acctccaccg gcgacgtggt ggacatctcc cccttctaca 20400 acggtactaa ccgtaacgct tcctacttcg gcgagaacgc tgacaagttc ttcatcttcc 20460 ccaactacac catcgtgtcc gacttcggtc gtcccaactc cgctctggaa acccaccgtc 20520 tggtggcttt cttggagcgt gctgactccg tgatctcctg ggacatccag gacgagaaga 20580 acgtgacctg ccagctgacc ttctgggagg cttccgagcg taccatccgt tccgaggctg 20640 aggactccta ccacttctcc agcgctaaga tgaccgctac cttcctgtcc aagaaacaag 20700 aggtcaacat gtccgactcc gccctggact gcgtgcgtga cgaggctatc aacaagctgc 20760 agcagatctt caacacctcc tacaaccaga cctacgagaa gtacggaaac gtgtccgtgt 20820 tcgagactac cggtggcctg gtggtgttct ggcagggtat caagcagaag tccctggtcg 20880 agctggaacg tctggctaac cgttcctccc tgaacctgac ccacaaccgt accaagcgtt 20940 ccaccgacgg caacaacgct actcacctgt ccaacatgga atccgtgcac aacctggtgt 21000 acgctcagct gcagttcacc tacgacaccc tgcgcggtta catcaaccgt gctctggctc 21060 agatcgctga ggcttggtgc gtggaccagc gtcgtaccct ggaagtgttc aaggaactgt 21120 ccaagatcaa cccctccgct atcctgtccg ccatctacaa caagcctatc gctgctcgtt 21180 tcatgggcga cgtgctgggc ctggcttcct gcgtgaccat caaccagact tccgtgaagg 21240 tgctgcgtga catgaacgtg aaggaatccc ccggtcgttg ctactcccgt cccgtggtca 21300 tcttcaactt cgctaactcc tcctacgtgc agtacggcca gctgggcgag gacaacgaga 21360 tcctgctggg caaccaccgt accgaggaat gccagctgcc ctccctgaag atcttcatcg 21420 ctggcaactc cgcttacgaa tacgtggact acctgttcaa gcgcatgatc gacctgtcct 21480 ccatctctac cgtggactcc atgatcgctc tggacatcga ccccctggaa aacaccgact 21540 tccgtgtgct ggaactgtac tcccagaagg aactgcgttc catcaacgtg ttcgacctgg 21600 aagagatcat gcgcgagttc aactcctaca agcagcgtgt taagtacgtc gaggacaagg 21660 tggtggaccc cctgcccccc tacctgaagg gactggacga cctgatgtcc ggcctgggag 21720 ctgccggcaa ggctgtgggt gtcgctatcg gtgctgtggg tggtgctgtg gcttccgtgg 21780 tcgagggtgt cgccaccttc ctgaagaacc ccttcggtgc tttcaccatc atcctggtgg 21840 ctatcgctgt ggtcatcatc atctacctga tctacacccg tcagcgtcgt ctgtgcatgc 21900 agcccctgca gaacctgttc ccctacctgg tgtccgctga cggtactacc gtgacctccg 21960 gcaacaccaa ggacacctcc ctgcaggctc ccccatccta cgaggaatcc gtctacaact 22020 ccggtcgcaa gggtcccggt cccccttcct ccgacgcttc taccgctgct cccccataca 22080 ccaacgagca ggcttaccag atgctgctgg ctctcgtgcg tctggacgct gagcagcgtg 22140 cacagcagaa cggcaccgac tccctggacg gccagaccgg aacccaggac aagggccaga 22200 agcccaacct gctggaccgt ctgcgtcacc gcaagaacgg ttaccgtcac ctgaaggact 22260 ccgacgagga agagaacgtc taaggcgcgc caagcttgtc gagaagtact agagatcata 22320 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 22380 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 22440 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 22500 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 22560 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg ggaatattaa 22620 tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt 22680 ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca 22740 ccatcgggcg cggatccgcc accatgcgtc ccggcctgcc ctcctacctg atcgtgctgg 22800 ctgtgtgcct gctgtcccac ctcctgtcct cccgttacgg tgctgaggct atctccgagc 22860 ccctggacaa ggctttccac ctcctgctga acacctacgg tcgtcctatc cgtttcctgc 22920 gcgagaacac cacccagtgc acctacaact cctccctgcg caactccacc gtcgtccgcg 22980 agaacgctat ctccttcaac ttcttccagt cctacaacca gtactacgtg ttccacatgc 23040 cccgttgcct gttcgctggt cccctggctg agcagttcct gaaccaggtg gacctgaccg 23100 agactctcga gcgttaccag cagcgtctga acacttacgc tctggtgtcc aaggacctgg 23160 cttcctaccg ttccttcagc cagcagctga aggctcagga ctccctgggc gagcagccca 23220 ccactgtgcc tccccctatc gacctgtcca tcccccacgt gtggatgccc ccccagacca 23280 ctcctcacgg ctggaccgag tcccacacca cctccggact gcaccgtccc cacttcaacc 23340 agacctgcat cctgttcgac ggtcacgacc tgctgttctc caccgtgacc ccctgcctgc 23400 accagggctt ctacctcatc gacgagctgc gttacgtgaa gatcaccctg accgaggatt 23460 tcttcgtggt caccgtgtcc atcgacgacg acacccccat gctgctgatc ttcggtcacc 23520 tcccccgtgt gctgttcaag gctccctacc agcgtgacaa cttcatcctg cgtcagaccg 23580 agaagcacga gctgctggtg ctggtcaaga aggaccagct gaaccgtcac tcttacctga 23640 aggaccccga cttcctggac gctgctctgg acttcaacta cctggacctg tccgctctgc 23700 tgaggaactc cttccaccgt tacgctgtgg acgtgctgaa gtccggtcgt tgccagatgc 23760 tggaccgtcg taccgtcgag atggctttcg cttacgccct ggctctgttc gctgctgctc 23820 gtcaagaaga ggctggcgct caggtgtccg tgccccgtgc tctggaccgt caggctgctc 23880 tgctgcagat ccaagagttc atgatcactt gcctgtccca gaccccccct cgtaccaccc 23940 tgctgctgta ccccaccgct gtggacctgg ctaagcgtgc tctgtggacc cccaaccaga 24000 tcaccgacat cacctccctc gtgcgtctgg tgtacatcct gtccaagcag aaccagcagc 24060 acctgatccc ccagtgggct ctgcgtcaga tcgctgactt cgctctgaag ctgcacaaga 24120 cccacctggc ttcattcctc agcgctttcg ctcgccaaga gctgtacctg atgggttccc 24180 tggtgcactc catgctggtg cacaccaccg agcgtcgcga gatcttcatc gtggaaaccg 24240 gcctgtgctc cctggccgag ctgtcccact tcacccagct gctggctcac ccccaccacg 24300 agtacctgtc cgacctgtac accccctgct cctcttccgg tcgtcgtgac cactccctgg 24360 aacgtctgac ccgtctgttc cccgacgcta ccgtgcctac caccgtgcct gctgctctgt 24420 ccatcctgtc taccatgcag ccctccaccc tggaaacctt ccccgacctg ttctgcctgc 24480 ctctgggcga gtccttctcc gctctgaccg tgtccgagca cgtgtcctac gtggtcacca 24540 accagtacct gatcaagggc atctcctacc ccgtgtccac caccgtcgtg ggccagtccc 24600 tgatcatcac ccagaccgac tcccagacca agtgcgagct gacccgtaac atgcacacca 24660 ctcactccat caccgctgct ctgaacatct ccctcgagaa ctgcgctttc tgccagtccg 24720 ctctgttgga gtacgacgac actcagggtg tcatcaacat catgtacatg cacgactccg 24780 acgacgtgct gttcgctctg gacccctaca acgaggtggt ggtgtcctcc ccccgtaccc 24840 actacctgat gctgctgaag aacggcaccg tgctggaagt gaccgacgtg gtggtggacg 24900 ctaccgaccg tctgctgatg atgtccgtgt acgctctgtc cgctatcatc ggcatctacc 24960 tgctgtaccg tatgctgaag acctgctaag gcgccaagct ttgtcgagaa gtactagagg 25020 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 25080 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 25140 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 25200 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggatc 25260 tgatcactgc ttgagcctag aagatccggc tgctaacaaa gcccgaaagg aagctgagtt 25320 ggctgctgcc accgctgagc aataactatc ataaccccta ggagatccga accagataag 25380 tgaaatctag ttccaaacta ttttgtcatt tttaattttc gtattagctt acgacgctac 25440 acccagttcc catctatttt gtcactcttc cctaaataat ccttaaaaac tccatttcca 25500 cccctcccag ttcccaacta ttttgtccgc ccaca 25535 <210> 91 <211> 25782 <212> DNA <213> Artificial <220> <223> Synthetic construct <400> 91 ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc 60 gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt 120 tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag 180 cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg 240 gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc 300 ttaatgcgcc gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg 360 gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag 420 gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag 480 tgcatagacc agccgcgtaa cctggcaaaa tcggttacgg ttgagtaata aatggatgcc 540 ctgcgtaagc gggtgtgggc ggacaataaa gtcttaaact gaacaaaata gatctaaact 600 atgacaataa agtcttaaac tagacagaat agttgtaaac tgaaatcagt ccagttatgc 660 tgtgaaaaag catactggac ttttgttatg gctaaagcaa actcttcatt ttctgaagtg 720 caaattgccc gtcgtattaa agaggggcgt ggccaagggc atggtaaaga ctatattcgc 780 ggcgttgtga caatttaccg aacaactccg cggccgggaa gccgatctcg gcttgaacga 840 attgttaggt ggcggtactt gggtcgatat caaagtgcat cacttcttcc cgtatgccca 900 actttgtata gagagccact gcgggatcgt caccgtaatc tgcttgcacg tagatcacat 960 aagcaccaag cgcgttggcc tcatgcttga ggagattgat gagcgcggtg gcaatgccct 1020 gcctccggtg ctcgccggag actgcgagat catagatata gatctcacta cgcggctgct 1080 caaacttggg cagaacgtaa gccgcgagag cgccaacaac cgcttcttgg tcgaaggcag 1140 caagcgcgat gaatgtctta ctacggagca agttcccgag gtaatcggag tccggctgat 1200 gttgggagta ggtggctacg tctccgaact cacgaccgaa aagatcaaga gcagcccgca 1260 tggatttgac ttggtcaggg ccgagcctac atgtgcgaat gatgcccata cttgagccac 1320 ctaactttgt tttagggcga ctgccctgct gcgtaacatc gttgctgctg cgtaacatcg 1380 ttgctgctcc ataacatcaa acatcgaccc acggcgtaac gcgcttgctg cttggatgcc 1440 cgaggcatag actgtacaaa aaaacagtca taacaagcca tgaaaaccgc cactgcgccg 1500 ttaccaccgc tgcgttcggt caaggttctg gaccagttgc gtgagcgcat acgctacttg 1560 cattacagtt tacgaaccga acaggcttat gtcaactggg tttgtgcctt catccgtttc 1620 cacggtgtgc gtcacccggc aaccttgggc agcagcgaag tcgaggcatt tctgtcctgg 1680 ctggcgaacg agcgcaaggt ttcggtctcc acgcatcgtc aggcattggc ggccttgctg 1740 ttcttctacg gcaaggtgct gtgcacggat ctgcccttgc ttcaggagat cggtagacct 1800 cggccgtcgc ggcgcttgcc ggtggtgctg accccggatg aagtggttcg catcctcggt 1860 tttctggaag gcgagcatcg tttgttcgcc caggactcta gctatagttc tagtggttgg 1920 ctacagcttt gtttgtacta tcaacaggtt gaactgctga tcaacagatc ctctacgcgg 1980 ccgcggtacc ataacttcgt atagcataca ttatacgaag ttatctggtt taaacgtacc 2040 cgtagtggct atggcagggc ttgccgcccc gacgttggct gcgagccctg ggccttcacc 2100 cgaacttggg ggttggggtg gggaaaagga agaaacgcgg gcgtattggt cccaatgggg 2160 tctcggtggg gtatcgacag agtgccagcc ctgggaccga accccgcgtt tatgaacaaa 2220 cgacccaaca cccgtgcgtt ttattctgtc tttttattgc cgtcatagcg cgggttcctt 2280 ccggtattgt ctccttccgt gtttcagtta gcctccccca tctcccggta ccgcatgcta 2340 tgcatcagct gctagcacca tggctcgaga tcccgggtga tcaagtcttc gtcgagtgat 2400 tgtaaataaa atgtaattta cagtatagta ttttaattaa tatacaaatg atttgataat 2460 aattcttatt taactataat atattgtgtt gggttgaatt aaaggtccgt atactagtat 2520 cgattcgcga cctactccgg aatattaata gatcatggag ataattaaaa tgataaccat 2580 ctcgcaaata aataagtatt ttactgtttt cgtaacagtt ttgtaataaa aaaacctata 2640 aatattccgg attattcata ccgtcccacc atcgggcgcg gatccgccac catggaaaac 2700 tggtccgctc tggaactgct gcccaaggtc ggaatcccta ccgacttcct gacccacgtc 2760 aagacctccg ctggcgagga aatgttcgag gctctgagga tctactacgg cgacgacccc 2820 gagcgttaca acatccactt cgaggctatc ttcggcacct tctgcaaccg tctggaatgg 2880 gtgtacttcc tgacttccgg cctggctgct gctgctcacg ctatcaagtt ccacgacctg 2940 aacaagctga ccaccggcaa gatgctgttc cacgtgcaag tgccccgtgt ggcttccggt 3000 gctggcctgc ctacctcccg tcagaccacc atcatggtca ccaagtactc cgagaagtcc 3060 cccatcacca tccctttcga gctgtccgct gcttgcctga cttacctgcg tgaaaccttc 3120 gagggcacca tcctggacaa gatcctgaac gtcgaggcta tgcacaccgt gctgcgtgct 3180 ctgaagaaca ccgctgacgc tatggaacgt ggcctgatcc acagcttcct ccagaccctg 3240 ctgaggaagg ctccccccta cttcgtggtg cagaccctgg tcgagaacgc taccctggct 3300 cgtcaggctc tgaaccgtat ccagcgctcc aacatcctgc agtccttcaa ggctaagatg 3360 ctggctaccc tgttcctgct gaaccgtacc cgtgaccgtg actacgtgct gaagttcctg 3420 acccgtctgg ctgaggctgc taccgactcc atcctcgaca accctactac ctacaccacc 3480 tcctccggtg ctaagatctc cggtgtcatg gtgtccaccg ctaacgtgat gcagatcatc 3540 atgtccctgc tgtcctccca catcactaag gaaaccgtgt ccgctcccgc tacctacggc 3600 aacttcgtgc tgtcccccga gaacgctgtg accgctatct cctaccactc tatcctggct 3660 gacttcaact cctacaaggc tcacctgacc tccggccagc cccacctccc caacgactcc 3720 ctgagccagg ctggtgctca ctccctgacc cccctgtcca tggacgtgat ccgtctgggc 3780 gaaaagaccg tgatcatgga aaacctgcgt cgcgtgtaca agaacaccga caccaaggac 3840 cccctggaac gtaacgtgga cctgaccttc ttcttccccg tgggcctgta cctgcccgag 3900 gaccgtggtt acaccaccgt cgagtccaag gtcaagctga acgacaccgt gcgtaacgct 3960 ctgcccacca ccgcttacct gctgaacagg gaccgtgctg tgcaaaagat cgacttcgtg 4020 gacgctctca agaccctgtg ccaccccgtg ctgcacgagc ctgctccatg cctgcaggct 4080 ttcaccgagc gtggtccccc atccgagccc gctatgcagc gtctgctgga atgccgtttc 4140 cagcaagagc ccatgggtgg tgctgctcgt cgtatccccc acttctaccg tgtgcgccgc 4200 gaggtgcccc gtaccgtgaa cgagatgaag caggacttcg tggtcaccga cttctacaag 4260 gttggaaaca tcaccctgta caccgagctg caccctttct tcgacttcac ccactgccaa 4320 gagaactccg agactgtggc tctgtgcacc ccccgtatcg tgatcggcaa cctgcccgac 4380 ggcctggctc ccggtccctt ccacgagctg aggacctggg agatcatgga acacatgcgc 4440 ctgcgtcccc cacccgacta cgaggaaacc ctgcgtctgt tcaagaccac cgtgacctcc 4500 cccaactacc ccgagctgtg ctacctggtg gacgtgctgg tgcacggcaa cgctgacgct 4560 ttcctgctga tccgcgcttt catcgctcgt tgcatcgtga acatgttcca cacccgtcag 4620 ctgctggtgt tcgctcactc ctacgctctg gtcaccctga tcgctgagca cctggctgac 4680 ggtgctctgc ccccccagct cctgttccac taccgtaacc tggtggctgt gctgcgcctg 4740 gtcacccgta tctccgctct gcccggcctg aacaacggcc agctggctga ggaacccctg 4800 tccgcttacg tgaacgctct gcacgaccac aggctgtggc cccccttcgt gacccacctc 4860 cctcgtaaca tggaaggtgt ccaggtggtg gctgatcgtc agcccctgaa ccccgctaac 4920 atcgaggctc gtcaccacgg tgtctccgac gtgccccgtc tgggtgctat ggacgctgac 4980 gagcccctgt tcgtggacga ctaccgtgct accgacgacg agtggaccct gcaaaaggtg 5040 ttctacctgt gcctgatccc cgctatgacc aacaaccgtg cttgcggcct gggcctgaac 5100 ctcaagactc tgctggtgga cctgttctac cgtcccgcct tcctgctcat gcccgctgct 5160 accgctgtgt ccacctccgg caccacctcc aaggaatcca cctctggtgt cacccccgag 5220 gactccgtgg ctgctcagcg tcaggctgtg ggcgagatgc tgaccgagct ggtcgaggac 5280 gtggccaccg acgctcacac ccctctgctg caggcttgcc gcgagctgtt cctggctgtg 5340 cagttcgtgg gcgagcacgt gaaggtgctg gaagtgcgtg ctcccctgga ccacgctcag 5400 aggcagggac tgcccgactt catctcccgt cagcatgtgc tgtacaacgg ttgctgcgtc 5460 gtgaccgctc ctaagaccct gatcgagtac tccctgcccg tgcccttcca ccgtttctac 5520 tccaacccca ccatctgcgc tgctctgtcc gacgacatca agcgttacgt gaccgagttc 5580 ccccactacc atagacacga tggtggtttc cccctgccca ccgctttcgc tcacgagtac 5640 cacaactggc tgcgtagccc cttctcccgt tactccgcta cctgccccaa cgtgctgcac 5700 tccgtgatga ccctggctgc tatgctgtac aagatctccc ccgtgtccct ggtgctgcag 5760 accaaggctc acatccaccc cggtttcgct ctgaccgctg tgcgtaccga caccttcgag 5820 gtggacatgc tgctgtactc cggcaagtcc tgcacctccg tcatcatcaa caaccccatc 5880 gtgaccaagg aagagaggga catctccacc acctaccacg tgacccagaa catcaacacc 5940 gtggacatgg gcctgggtta cacctccaac acttgcgtgg cctacgtgaa ccgcgtccgc 6000 accgacatgg gtgtccgtgt gcaggacctg ttccgtgtgt tccccatgaa cgtgtaccgc 6060 cacgatgagg tggaccgttg gatcaggcac gctgctggcg tcgagcgtcc ccagctgctg 6120 gacaccgaga ctatctccat gctgaccttc ggttccatgt ccgagcgcaa cgctgctgct 6180 accgtgcacg gccagaaggc tgtctgcgag ctgatcctga cccctgtgac tatggacgtg 6240 aactacttca agatcaccaa caaccctcgt ggtcgtgctt cctgcatgct gggcgtggac 6300 ccctacgaca ccgaggctgc caccaaggct atctacgacc accgcgaggc tgacgctcag 6360 accttcgctg ctacccacaa cccatgggct tcccaggctg gttgcctgtc cgacgtcctg 6420 tacaacaccc gtcaccgcga gcgtctgggc tacaactcca agttctactc cccctgcgct 6480 cagtacttca acaccgagga aatcatcgct gccaacaaga ccctcttcaa gaccatcgac 6540 gagtacctgc tgcgcgctaa ggactgcatc cgtggcgaca ccgacactca gtacgtgtgc 6600 gtcgagggaa ccgagcagct gatcgagaac ccttgccgtc tgacccaaga ggctctgccc 6660 atcctgtcca ccaccaccct ggctctgatg gaaactaagc tgaagggtgg cgctggtgct 6720 ttcgctacct ccgagactca cttcggcaac tacgtcgtgg gagagatcat ccccctgcag 6780 cagtccatgc tgttcaacag ctaagagctc aagcttgtcg agaagtacta gaggatcata 6840 atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 6900 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 6960 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 7020 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatctgatca 7080 ctgcttgagc ctagaagatc cggctgctaa caaagcccga aaggaagctg agttggctgc 7140 tgtggctagc tttgtttaac tttaagaagg agatacatct agaaatatta atagatcatg 7200 gagataatta aaatgataac catctcgcaa ataaataagt attttactgt tttcgtaaca 7260 gttttgtaat aaaaaaacct ataaatattc cggattattc ataccgtccc accatcgggc 7320 gcggatccgc caccatggct gctatggaag ctaacatctt ctgcaccttc gaccacaagc 7380 tgtctatcgc tgacgtgggc aagctgacca agctggtggc tgctgtggtg cccatccccc 7440 agcgtctgca cctgatcaag cactaccagc tgggcctgca ccagttcgtg gaccacaccc 7500 gtggttacgt gcgtctgcgt ggcctgctgc gtaacatgac cctgaccctg atgcgtcgtg 7560 tcgagggcaa ccagatcctg ctgcacgtgc ccacccacgg cctgctgtac accgtgctga 7620 acaccggtcc cgtgacctgg gagaagggcg acgctctgtg cgtgctgccc cccctgttcc 7680 acggtcccct ggctcgtgaa aacctgttga ccctgggcca gtgggagctg gtgctgccct 7740 ggatcgtgcc catgcccctg gctctggaaa tcaaccagcg cctgctgatc atgggcctgt 7800 tctccctgga ccgttcctac gaagaagtga aggctgctgt ccagcagctg cagaccatca 7860 ccttccgtga cgctaccttc accatccccg accccgtgat cgaccagcac ctcctgatcg 7920 acatgaagac cgcttgcctg tccatgtcca tggtggctaa cctggcttcc gagctgacca 7980 tgacctacgt ccgcaagctg gctttggagg actcttccat gctgctggtc aagtgccaag 8040 agctgctgat gcgtctggac cgcgagcgtt ccgtgggcga gcctcgtact cccgctcgtc 8100 ctcagcacgt gtcccccgac gacgagatcg ctcgtctgtc cgctctgttc gtgatgctgc 8160 gtcagctgga cgacctgatc cgcgagcagg tcgtgttcac cgtgtgcgac gtgagcccag 8220 acaacaagtc cgctacctgc atcttcaagg gctaaggcgc gccaagcttg tcgagaagta 8280 ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 8340 cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 8400 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 8460 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 8520 ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag 8580 ctgagttggc tgctgggtgc ctaatgagtg agctaactca cattaattgc ccggaatatt 8640 aatagatcat ggagataatt aaaatgataa ccatctcgca aataaataag tattttactg 8700 ttttcgtaac agttttgtaa taaaaaaacc tataaatatt ccggattatt cataccgtcc 8760 caccatcggg cgcggatccc ggtccgaagc gcgcggaatt caaaggccta cgtcgacgcc 8820 accatgtcca acaccgctcc cggtcccacc gtggctaaca agcgtgacga gaagcaccgt 8880 cacgtggtca acgtggtgct cgagctgccc accgagatct ccgaggctac ccaccccgtg 8940 ctggctacca tgctgtccaa gtacacccgt atgtcctccc tgttcaacga caagtgcgct 9000 ttcaagctgg acctgctgcg tatggtggct gtgtcccgta cccgtcgcta aaagcttgtc 9060 gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta 9120 aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt 9180 aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca 9240 aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct 9300 tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg 9360 aaaggaagct gagttggctg ctgggtgcct aatgagtgag ctaactcaca ttaattgccc 9420 ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta 9480 ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca 9540 taccgtccca ccatcgggcg cggatcccgg tccgaagcgc gcggaattca aaggcctacg 9600 tcgacgccac catggaatcc cgtggtcgtc gttgccccga gatgatctcc gtgctgggtc 9660 ccatctccgg tcacgtcctg aaggctgtgt tctcccgtgg cgacaccccc gtgctgcccc 9720 acgaaactcg tctgctgcag accggtatcc acgtgcgtgt gtcccagccc tccctgatcc 9780 tggtgtccca gtacaccccc gactccaccc cttgccaccg cggagacaac cagctgcagg 9840 tccagcacac ctacttcacc ggttccgagg tcgagaacgt gtccgtgaac gtgcacaacc 9900 ccaccggtcg ttccatctgc ccctcccaag agcccatgtc catctacgtg tacgctctgc 9960 ccctgaagat gctgaacatc ccctccatca acgtgcacca ctacccctcc gctgctgagc 10020 gcaagcaccg tcacctcccc gtggctgacg ctgtgatcca cgcttccggc aagcagatgt 10080 ggcaggctcg tctgaccgtg tccggcctgg cttggacccg tcagcagaac cagtggaagg 10140 aacccgacgt gtactacacc tccgctttcg tgttccccac caaggacgtg gccctgcgtc 10200 acgtcgtgtg cgctcacgaa ctcgtgtgct ccatggaaaa cacccgtgct accaagatgc 10260 aagtgatcgg cgaccagtac gtgaaggtgt acctggaatc cttctgcgag gacgtgccct 10320 ccggcaagct gttcatgcac gtgaccctgg gttccgacgt ggaagaggac ctgaccatga 10380 cccgtaaccc ccagcccttc atgcgtcccc acgagcgtaa cggtttcacc gtgctgtgcc 10440 ccaagaacat gatcatcaag cccggcaaga tctcccacat catgctggac gtggccttca 10500 cctcccacga gcacttcggc ctgctgtgcc ctaagtccat ccccggcctg tccatctccg 10560 gcaacctgct gatgaacggc cagcagatct tcctggaagt gcaggctatc cgtgaaaccg 10620 tcgagctgcg tcagtacgac cctgtggctg ctctgttctt cttcgacatc gacctgctgc 10680 tgcagcgtgg tccccagtac tccgagcacc ccaccttcac cagccagtac cgtatccagg 10740 gcaagctgga ataccgtcac acctgggacc gtcacgacga gggtgctgct cagggcgacg 10800 acgacgtgtg gacctccggt tccgactccg acgaggaact ggtcaccacc gagcgcaaga 10860 ccccccgtgt gaccggtggt ggtgctatgg ctggtgcttc cacctccgct ggtcgcaagc 10920 gcaagtccgc ttcctccgct accgcttgca ccgctggtgt catgacccgt ggtcgcctga 10980 aggctgagtc caccgtggct cccgaagagg acactgacga ggactccgac aacgagatcc 11040 acaaccccgc tgtgttcacc tggcccccct ggcaggctgg tatcctggct cgtaacctgg 11100 tgcccatggt ggctaccgtg cagggccaga acctgaagta ccaagagttc ttctgggacg 11160 ccaacgacat ctaccgtatc ttcgctgagc tggaaggcgt gtggcagccc gctgctcagc 11220 ccaagcgtcg tcgtcaccgt caggacgctc tgcctggtcc ctgtatcgct tccaccccca 11280 agaagcaccg cggctaaaag cttgtcgaga agtactagag gatcataatc agccatacca 11340 catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac 11400 ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat 11460 aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg 11520 gtttgtccaa actcatcaat gtatcttatc atgtctggat ctgatcactg cttgagccta 11580 gaagatccgg ctgctaacaa agcccgaaag gaagctggga atattaatag atcaatggag 11640 ataattaaaa tgataaccat ctcgcaaata aataagtatt ttactgtttt cgtaacagtt 11700 ttgtaataaa aaaacctata aatattccgg attattcata ccgtcccacc atcgggcgcg 11760 gatccgccac catggccccc tcccacgtgg acaaggtgaa cacccgcacc tggtccgcct 11820 ccatcgtgtt catggtgctg accttcgtga acgtgtccgt gcacctggtg ctgtccaact 11880 tcccccacct gggctacccc tgcgtgtact accacgtggt ggacttcgag cgcctgaaca 11940 tgtccgccta caacgtgatg cacctgcaca cccccatgct gttcctggac tccgtgcagc 12000 tggtgtgcta cgccgtgttc atgcagctgg tgttcctggc cgtgaccatc tactacctgg 12060 tgtgctggat caagatctcc atgcgcaagg acaagggcat gtccctgaac cagtccaccc 12120 gcgacatctc ctacatgggc gactccctga ccgccttcct gttcatcctg tccatggaca 12180 ccttccagct gttcaccctg accatgtcct tccgcctgcc ctccatgatc gccttcatgg 12240 ccgccgtgca cttcttctgc ctgaccatct tcaacgtgtc catggtgacc cagtaccgct 12300 cctacaagcg ctccctgttc ttcttctccc gcctgcaccc caagctgaag ggcaccgtgc 12360 agttccgcac cctgatcgtg aacctggtgg aggtggccct gggcttcaac accaccgtgg 12420 tggccatggc cctgtgctac ggcttcggca acaacttctt cgtgcgcacc ggccacatgg 12480 tgctggccgt gttcgtggtg tacgccatca tctccatcat ctacttcctg ctgatcgagg 12540 ccgtgttctt ccagtacgtg aaggtgcagt tcggctacca cctgggcgcc ttcttcggcc 12600 tgtgcggcct gatctacccc atcgtgcagt acgacacctt cctgtccaac gagtaccgca 12660 ccggcatctc ctggtccttc ggcatgctgt tcttcatctg ggccatgttc accacctgcc 12720 gcgccgtgcg ctacttccgc ggccgcggct ccggctccgt gaagtaccag gccctggcca 12780 ccgcctccgg cgaggaggtg gccgccctgt cccaccacga ctccctggag tcccgccgcc 12840 tgcgcgagga ggaggacgac gacgacgacg aggacttcga ggacgcctaa gagctcaagc 12900 ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag gttttacttg 12960 ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg 13020 ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt 13080 tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg 13140 tatcttatca tgtctggatc tgatcactgc ttgagcctag aagatccggc tgctaacaaa 13200 gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactatc ataaccccta 13260 ggggcctcta aacgggtctt gaggggtttt ttgctgaaag gaggaactat atccggatct 13320 gaacaggagg gacagctgat agaaacagaa gccactggag cacctcaaaa acaccatcat 13380 acactaaatc agtaagttgg cagcatcacc cgacgcactt tgcgccgaat aaatacctgt 13440 gacggaagat cacttcgcag aataaataaa tcctggtgtc cctgttgata ccgggaagcc 13500 ctgggccaac ttttggcgaa aatgagacgt tgatcggcac gtaagaggtt ccaactttca 13560 ccataatgaa ataagatcac taccgggcgt attttttgag ttatcgagat tttcaggagc 13620 taaggaagct aaaatggaga aaaaaatcac tggatatacc accgttgata tatcccaatg 13680 gcatcgtaaa gaacattttg aggcatttca gtcagttgct caatgtacct ataaccagac 13740 cgttcagctg gatattacgg cctttttaaa gaccgtaaag aaaaataagc acaagtttta 13800 tccggccttt attcacattc ttgcccgcct gatgaatgct catccggaat tccgtatggc 13860 aatgaaagac ggtgagctgg tgatatggga tagtgttcac ccttgttaca ccgttttcca 13920 tgagcaaact gaaacgtttt catcgctctg gagtgaatac cacgacgatt tccggcagtt 13980 tctacacata tattcgcaag atgtggcgtg ttacggtgaa aacctggcct atttccctaa 14040 agggtttatt gagaatatgt ttttcgtctc agccaatccc tgggtgagtt tcaccagttt 14100 tgatttaaac gtggccaata tggacaactt cttcgccccc gttttcacca tgggcaaata 14160 ttatacgcaa ggcgacaagg tgctgatgcc gctggcgatt caggttcatc atgccgtttg 14220 tgatggcttc catgtcggca gaatgcttaa tgaattacaa cagtactgcg atgagtggca 14280 gggcggggcg taattttttt aaggcagtta ttggtgccct taaacgcctg gttgctacgc 14340 ctgaataagt gataataagc ggatgaatgg cagaaattcg aaagcaaatt cgacccggtc 14400 gtcggttcag ggcagggtcg ttaaatagcc gcttatgtct attgctggtt taccggttta 14460 ttgactaccg gaagcagtgt gaccgtgtgc ttctcaaatg cctgaggcca gtttgctcag 14520 gctctccccg tggaggtaat aattgacgat atgatcattt attctgcctc ccagctgaca 14580 ttcatccggg gtcagcaccg tttctgcgga ctggctttct acgtgttccg cttcctttag 14640 cagcccttgc gccctgagtg cttgcggcag cgtgaagcta attctgtcag ccgttaagtg 14700 ttcctgtgtc actcaaaatt gctttgagag gctctaaggg cttctcagtg cgttacatcc 14760 ctggcttgtt gtccacaacc gttaaacctt aaaagcttta aaagccttat atattctttt 14820 ttttcttata aaacttaaaa ccttagaggc tatttaagtt gctgatttat attaatttta 14880 ttgttcaaac atgagagctt agtacgtgaa acatgagagc ttagtacgtt agccatgaga 14940 gcttagtacg ttagccatga gggtttagtt cgttaaacat gagagcttag tacgttaaac 15000 atgagagctt agtacgtgaa acatgagagc ttagtacgta ctatcaacag gttgaactgc 15060 tgatcaacag atcctctacg cggccgcggt accataactt cgtatagcat acattatacg 15120 aagttatctg gtttaaacgt acccgtagtg gctatggcag ggcttgccgc cccgacgttg 15180 gctgcgagcc ctgggccttc acccgaactt gggggttggg gtggggaaaa ggaagaaacg 15240 cgggcgtatt ggtcccaatg gggtctcggt ggggtatcga cagagtgcca gccctgggac 15300 cgaaccccgc gtttatgaac aaacgaccca acacccgtgc gttttattct gtctttttat 15360 tgccgtcata gcgcgggttc cttccggtat tgtctccttc cgtgtttcag ttagcctccc 15420 ccatctcccg gtaccgcatg ctatgcatca gctgctagct tagcgagcgt ccacagcctg 15480 gggaccgtaa cgggagtgag cgggcaggtt cacacgggtc tgcttcagct cagggggcag 15540 gccagcgtag tacttgtcca ggtgacgcag cagggggggg tccagctggt gacgcaggca 15600 gaattccttc acagcgttgt acaggccgta gaacagggtg ataccctcgg gagcagcagc 15660 ggtggacacg ggcagacgca cagcacggtt ggtacgggta gcctcgttac ggatagccac 15720 caccacgttg aacagggagg ggggcaccag ctcgaaaccc agcacgtgtt cggtgaagat 15780 ggaacgaccg taggacagac gagtcaggtc gtaaccacgg cacaggtcgt ccacgcaagt 15840 gtacacagcg ggggaaccgt cgccgcactc ggagtaaccg cgcatcacgg tcatccaacg 15900 gggagcggtg tcggaggaca gcagggtcag cagagcacgc agctggtcgg ggttgttgta 15960 cagcagggcc agggtgtcca ggaaagcgtc gtccagcagc acggagttag cagcctcggg 16020 ggtcacggga cggtaacgga tcagctggga caggggaccg tccctacggg tcacgttgac 16080 caggggacgc agccaggact cgtacttgtc gccctggaac acctctccca gcaggcaacg 16140 acgggtcagc tcggggcact cagcgggcac cttctcagcc acggtgggag ccacggacac 16200 ggtagcggag gacacgatgg gcagcagcag gcagcaccac agcagagcca cgggaccggg 16260 ggagaaggag aaaccgcagt cgggacgacg gcacatggtg gctcgagatc ccgggtgatc 16320 aagtcttcgt cgagtgattg taaataaaat gtaatttaca gtatagtatt ttaattaata 16380 tacaaatgat ttgataataa ttcttattta actataatat attgtgttgg gttgaattaa 16440 aggtccgtat actagtatcg attcgcgacc tactccggaa tattaataga tcatggagat 16500 aattaaaatg ataaccatct cgcaaataaa taagtatttt actgttttcg taacagtttt 16560 gtaataaaaa aacctataaa tattccggat tattcatacc gtcccaccat cgggcgcgga 16620 tccgccacca tgaactccaa ggacctgacc cccttcctga ccaccctgtg gctgctgctg 16680 gaccactccc gtgtgcctcg tgtgcgtgct gaggaatgct gcgaagtgat caacgtgaac 16740 cacccccccg agcgctgcta cgacttcaag atgtgcaacc tgttcaccgt ggctctgcgt 16800 tgccccgacg gcgaagtgtg ctactccccc gaaaagaccg ctgagatccg tggtatcgtg 16860 accaccatga cccactccct gacccgtcaa gtgatccaca acaagctgac cagctgcaac 16920 tacaaccccc tgtacctcga ggctgacggt cgtatccgtt gcggcaaggt gtccgacaag 16980 gctcagtacc tgctgggtgc tgctggttcc gtgccctacc gttggatcaa cctcgagtac 17040 gacaagatca cccgtatcgt gggcctggac cagtacctcg agtccgtgaa gaagcacaag 17100 cgtctggacg tgtgccgtgc taagatgggt tacatgctgc agtaaaagct tgtcgagaag 17160 tactagagga tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac 17220 ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg 17280 tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa 17340 gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat 17400 gtctggatct gatcactgct tgagcctaga agatccggct gctaacaaag cccgaaagga 17460 agctgagttg gctgctgtgg ctagctttgt ttaactttaa gaaggagata catctagacc 17520 ggaatattaa tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta 17580 ttttactgtt ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca 17640 taccgtccca ccatcgggcg cggatccgcc accatgctgc gtctgctgct gcgtcaccac 17700 ttccactgcc tgctgctgtg cgctgtgtgg gctaccccct gcctggcttc cccctggttc 17760 accctgaccg ctaaccagaa cccctcccca ccctggtcca agctgaccta ccccaagccc 17820 cacgacgctg ctaccttcta ctgccccttc ctgtacccat ccccacctcg ttccccatcc 17880 cagttctccg gtttccagcg tgtgtccacc ggtcccgagt gccgtaacga gactctgtac 17940 ctgctgtaca accgcgaggg ccagaccctg gtcgagaggt cctccacctg ggtcaagaag 18000 gtcatctggt acttgtccgg tcgtaaccag accatcctgc agcgtatgcc ccgtaccgct 18060 tccaagccct ccgacggcaa cgtgcagatc tccgtcgagg acgctaagat cttcggtgct 18120 cacatggtgc ccaagcagac caagctgctg cgtttcgtgg tcaacgacgg cacccgttac 18180 cagatgtgcg tgatgaagct ggaatcctgg gctcacgtgt tccgtgacta ctccgtgtcc 18240 ttccaagtgc gcctgacctt caccgaggct aacaaccaga cctacacctt ctgcacccac 18300 cccaacctga tcgtgtaagt cgacaagctt gtcgagaagt actagaggat cataatcagc 18360 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 18420 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 18480 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 18540 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatctg atcactgctt 18600 gagcctagaa gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgggtg 18660 cctaatgagt gagctaactc acattaattg cccggaatat taatagatca tggagataat 18720 taaaatgata accatctcgc aaataaataa gtattttact gttttcgtaa cagttttgta 18780 ataaaaaaac ctataaatat tccggattat tcataccgtc ccaccatcgg gcgcggatcc 18840 gccaccggat ccgccaccat gcgtctgtgc cgtgtgtggc tgtccgtgtg cctgtgcgct 18900 gtggtgctgg gacagtgcca gcgtgaaacc gctgagaaga acgactacta ccgtgtgccc 18960 cactactggg acgcttgctc ccgtgctctg cccgaccaga cccgttacaa gtacgtcgag 19020 cagctggtgg acctgaccct gaactaccac tacgacgctt cccacggcct ggacaacttc 19080 gacgtgctga agcgtatcaa cgtgaccgag gtgtccctgc tgatctccga cttccgtcgt 19140 cagaaccgtc gtggtggcac caacaagcgt accaccttca acgctgctgg ttccctggct 19200 ccccacgctc gttccttgga gttctccgtg cgtctgttcg ccaactaata aaagcttgtc 19260 gagaagtact agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta 19320 aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt 19380 aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca 19440 aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct 19500 tatcatgtct ggatctgatc actgcttgag cctagaagat ccggctgcta acaaagcccg 19560 aaaggaagct gagttggctg ctgccaccgc tgagcaataa ctatcataac ccccggaata 19620 ttaatagatc atggagataa ttaaaatgat aaccatctcg caaataaata agtattttac 19680 tgttttcgta acagttttgt aataaaaaaa cctataaata ttccggatta ttcataccgt 19740 cccaccatcg ggcgcggatc ccggtccgaa gcgcgcggaa ttcaaaggcc taccgtcgac 19800 gccaccatgg aatcccgtat ctggtgcctg gtcgtgtgcg tgaacctgtg catcgtgtgc 19860 ctgggtgctg ctgtgtcctc ctcctccacc cgtggcacct ccgctaccca ctcccaccac 19920 tcctcccaca ccacctccgc cgctcactcc cgttccggtt ccgtgtccca gcgtgtgacc 19980 tcctcccaga ccgtgtccca cggtgtcaac gagactatct acaacaccac cctgaagtac 20040 ggcgacgtcg tgggtgtcaa caccaccaag tacccctacc gtgtgtgctc catggctcag 20100 ggcaccgacc tgatccgttt cgagcgtaac atcgtgtgca cctccatgaa gcccatcaac 20160 gaggacctgg acgagggtat catggtggtg tacaagcgca acatcgtggc tcacaccttc 20220 aaggtccgcg tgtaccagaa ggtgctgacc ttccgtcgtt cctacgctta catccacacc 20280 acttacctgc tgggttccaa caccgagtac gtggcccctc ccatgtggga gatccaccac 20340 atcaactccc actcccagtg ctactcctct tactcccgtg tgatcgctgg caccgtgttc 20400 gtggcttacc accgtgactc ctacgagaac aagaccatgc agctgatgcc cgacgactac 20460 tccaacaccc actccacccg ttacgtgacc gtgaaggacc agtggcactc ccgtggttcc 20520 acctggctgt accgtgaaac ctgcaacctg aactgcatgg tcaccatcac caccgctcgt 20580 tccaagtacc cttaccactt cttcgctacc tccaccggcg acgtggtgga catctccccc 20640 ttctacaacg gtactaaccg taacgcttcc tacttcggcg agaacgctga caagttcttc 20700 atcttcccca actacaccat cgtgtccgac ttcggtcgtc ccaactccgc tctggaaacc 20760 caccgtctgg tggctttctt ggagcgtgct gactccgtga tctcctggga catccaggac 20820 gagaagaacg tgacctgcca gctgaccttc tgggaggctt ccgagcgtac catccgttcc 20880 gaggctgagg actcctacca cttctccagc gctaagatga ccgctacctt cctgtccaag 20940 aaacaagagg tcaacatgtc cgactccgcc ctggactgcg tgcgtgacga ggctatcaac 21000 aagctgcagc agatcttcaa cacctcctac aaccagacct acgagaagta cggaaacgtg 21060 tccgtgttcg agactaccgg tggcctggtg gtgttctggc agggtatcaa gcagaagtcc 21120 ctggtcgagc tggaacgtct ggctaaccgt tcctccctga acctgaccca caaccgtacc 21180 aagcgttcca ccgacggcaa caacgctact cacctgtcca acatggaatc cgtgcacaac 21240 ctggtgtacg ctcagctgca gttcacctac gacaccctgc gcggttacat caaccgtgct 21300 ctggctcaga tcgctgaggc ttggtgcgtg gaccagcgtc gtaccctgga agtgttcaag 21360 gaactgtcca agatcaaccc ctccgctatc ctgtccgcca tctacaacaa gcctatcgct 21420 gctcgtttca tgggcgacgt gctgggcctg gcttcctgcg tgaccatcaa ccagacttcc 21480 gtgaaggtgc tgcgtgacat gaacgtgaag gaatcccccg gtcgttgcta ctcccgtccc 21540 gtggtcatct tcaacttcgc taactcctcc tacgtgcagt acggccagct gggcgaggac 21600 aacgagatcc tgctgggcaa ccaccgtacc gaggaatgcc agctgccctc cctgaagatc 21660 ttcatcgctg gcaactccgc ttacgaatac gtggactacc tgttcaagcg catgatcgac 21720 ctgtcctcca tctctaccgt ggactccatg atcgctctgg acatcgaccc cctggaaaac 21780 accgacttcc gtgtgctgga actgtactcc cagaaggaac tgcgttccat caacgtgttc 21840 gacctggaag agatcatgcg cgagttcaac tcctacaagc agcgtgttaa gtacgtcgag 21900 gacaaggtgg tggaccccct gcccccctac ctgaagggac tggacgacct gatgtccggc 21960 ctgggagctg ccggcaaggc tgtgggtgtc gctatcggtg ctgtgggtgg tgctgtggct 22020 tccgtggtcg agggtgtcgc caccttcctg aagaacccct tcggtgcttt caccatcatc 22080 ctggtggcta tcgctgtggt catcatcatc tacctgatct acacccgtca gcgtcgtctg 22140 tgcatgcagc ccctgcagaa cctgttcccc tacctggtgt ccgctgacgg tactaccgtg 22200 acctccggca acaccaagga cacctccctg caggctcccc catcctacga ggaatccgtc 22260 tacaactccg gtcgcaaggg tcccggtccc ccttcctccg acgcttctac cgctgctccc 22320 ccatacacca acgagcaggc ttaccagatg ctgctggctc tcgtgcgtct ggacgctgag 22380 cagcgtgcac agcagaacgg caccgactcc ctggacggcc agaccggaac ccaggacaag 22440 ggccagaagc ccaacctgct ggaccgtctg cgtcaccgca agaacggtta ccgtcacctg 22500 aaggactccg acgaggaaga gaacgtctaa ggcgcgccaa gcttgtcgag aagtactaga 22560 gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca 22620 cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc 22680 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 22740 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat 22800 ctgatcactg cttgagccta gaagatccgg ctgctaacaa agcccgaaag gaagctggga 22860 atattaatag atcatggaga taattaaaat gataaccatc tcgcaaataa ataagtattt 22920 tactgttttc gtaacagttt tgtaataaaa aaacctataa atattccgga ttattcatac 22980 cgtcccacca tcgggcgcgg atccgccacc atgcgtcccg gcctgccctc ctacctgatc 23040 gtgctggctg tgtgcctgct gtcccacctc ctgtcctccc gttacggtgc tgaggctatc 23100 tccgagcccc tggacaaggc tttccacctc ctgctgaaca cctacggtcg tcctatccgt 23160 ttcctgcgcg agaacaccac ccagtgcacc tacaactcct ccctgcgcaa ctccaccgtc 23220 gtccgcgaga acgctatctc cttcaacttc ttccagtcct acaaccagta ctacgtgttc 23280 cacatgcccc gttgcctgtt cgctggtccc ctggctgagc agttcctgaa ccaggtggac 23340 ctgaccgaga ctctcgagcg ttaccagcag cgtctgaaca cttacgctct ggtgtccaag 23400 gacctggctt cctaccgttc cttcagccag cagctgaagg ctcaggactc cctgggcgag 23460 cagcccacca ctgtgcctcc ccctatcgac ctgtccatcc cccacgtgtg gatgcccccc 23520 cagaccactc ctcacggctg gaccgagtcc cacaccacct ccggactgca ccgtccccac 23580 ttcaaccaga cctgcatcct gttcgacggt cacgacctgc tgttctccac cgtgaccccc 23640 tgcctgcacc agggcttcta cctcatcgac gagctgcgtt acgtgaagat caccctgacc 23700 gaggatttct tcgtggtcac cgtgtccatc gacgacgaca cccccatgct gctgatcttc 23760 ggtcacctcc cccgtgtgct gttcaaggct ccctaccagc gtgacaactt catcctgcgt 23820 cagaccgaga agcacgagct gctggtgctg gtcaagaagg accagctgaa ccgtcactct 23880 tacctgaagg accccgactt cctggacgct gctctggact tcaactacct ggacctgtcc 23940 gctctgctga ggaactcctt ccaccgttac gctgtggacg tgctgaagtc cggtcgttgc 24000 cagatgctgg accgtcgtac cgtcgagatg gctttcgctt acgccctggc tctgttcgct 24060 gctgctcgtc aagaagaggc tggcgctcag gtgtccgtgc cccgtgctct ggaccgtcag 24120 gctgctctgc tgcagatcca agagttcatg atcacttgcc tgtcccagac cccccctcgt 24180 accaccctgc tgctgtaccc caccgctgtg gacctggcta agcgtgctct gtggaccccc 24240 aaccagatca ccgacatcac ctccctcgtg cgtctggtgt acatcctgtc caagcagaac 24300 cagcagcacc tgatccccca gtgggctctg cgtcagatcg ctgacttcgc tctgaagctg 24360 cacaagaccc acctggcttc attcctcagc gctttcgctc gccaagagct gtacctgatg 24420 ggttccctgg tgcactccat gctggtgcac accaccgagc gtcgcgagat cttcatcgtg 24480 gaaaccggcc tgtgctccct ggccgagctg tcccacttca cccagctgct ggctcacccc 24540 caccacgagt acctgtccga cctgtacacc ccctgctcct cttccggtcg tcgtgaccac 24600 tccctggaac gtctgacccg tctgttcccc gacgctaccg tgcctaccac cgtgcctgct 24660 gctctgtcca tcctgtctac catgcagccc tccaccctgg aaaccttccc cgacctgttc 24720 tgcctgcctc tgggcgagtc cttctccgct ctgaccgtgt ccgagcacgt gtcctacgtg 24780 gtcaccaacc agtacctgat caagggcatc tcctaccccg tgtccaccac cgtcgtgggc 24840 cagtccctga tcatcaccca gaccgactcc cagaccaagt gcgagctgac ccgtaacatg 24900 cacaccactc actccatcac cgctgctctg aacatctccc tcgagaactg cgctttctgc 24960 cagtccgctc tgttggagta cgacgacact cagggtgtca tcaacatcat gtacatgcac 25020 gactccgacg acgtgctgtt cgctctggac ccctacaacg aggtggtggt gtcctccccc 25080 cgtacccact acctgatgct gctgaagaac ggcaccgtgc tggaagtgac cgacgtggtg 25140 gtggacgcta ccgaccgtct gctgatgatg tccgtgtacg ctctgtccgc tatcatcggc 25200 atctacctgc tgtaccgtat gctgaagacc tgctaaggcg ccaagctttg tcgagaagta 25260 ctagaggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 25320 cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 25380 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 25440 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 25500 ctggatctga tcactgcttg agcctagaag atccggctgc taacaaagcc cgaaaggaag 25560 ctgagttggc tgctgccacc gctgagcaat aactatcata acccctagga gatccgaacc 25620 agataagtga aatctagttc caaactattt tgtcattttt aattttcgta ttagcttacg 25680 acgctacacc cagttcccat ctattttgtc actcttccct aaataatcct taaaaactcc 25740 atttccaccc ctcccagttc ccaactattt tgtccgccca ca 25782

Claims (18)

1종 이상의 캡시드 또는 캡시드 전구체 단백질, 3종 이상의 시토메갈로바이러스 (CMV) 유래 표면 단백질, 및 임의로 1종 이상의 외피 단백질을 포함하는 재조합 바이러스-유사 입자.

제1항에 있어서, 1종 이상의 캡시드 또는 캡시드 전구체 단백질, 5종 이상의 시토메갈로바이러스 (CMV) 유래 표면 단백질, 및 임의로 1종 이상의 외피 단백질을 포함하는 재조합 바이러스-유사 입자.

제1항 또는 제2항에 있어서, 1종 이상의 헤르페스 바이러스 유래 캡시드 단백질, 및 1종 이상의 인간 시토메갈로바이러스 (HCMV) 유래 외피 단백질을 포함하는 재조합 바이러스-유사 입자.

제1항 또는 제2항에 있어서, 1종 이상의 레트로바이러스 유래 캡시드 또는 캡시드 전구체 단백질을 포함하는 재조합 바이러스-유사 입자.

제1항 또는 제2항에 있어서, 1종 이상의 헤르페스 바이러스 유래 캡시드 단백질, 3종 이상의 인간 시토메갈로바이러스 (HCMV) 유래 표면 단백질, 및 임의로 1종 이상의 인간 시토메갈로바이러스 (HCMV) 유래 외피 단백질을 포함하는 재조합 바이러스-유사 입자.

제3항에 있어서, 헤르페스바이러스가 인간 시토메갈로바이러스 HCMV인 재조합 바이러스-유사 입자.

제4항에 있어서, 1종 이상의 레트로바이러스 유래 캡시드 또는 캡시드 전구체 단백질이 gag인 재조합 바이러스-유사 입자.

제1항 내지 제7항 중 어느 한 항에 있어서, 시토메갈로바이러스 표면 단백질이 gpUL75 (gH), gpUL115 (gL), gpUL55 (gB), gpUL74 (gO), gpUL100 (gM), gpUL73 (gN), gpUL128, gpUL130 및 gpUL131A로 이루어진 군으로부터 선택되는 것인 재조합 바이러스-유사 입자.

제1항 내지 제7항 중 어느 한 항에 있어서, 외피 단백질이 pUL83 및 pUL32로 이루어진 군으로부터 선택되는 것인 재조합 바이러스-유사 입자.

제1항 내지 제9항 중 어느 한 항에 따른 바이러스-유사 입자에 포함되어 있는 단백질을 코딩하는 DNA.

제10항에 따른 DNA를 포함하는 벡터.

제11항에 따른 바큘로바이러스 벡터.

제11항 또는 제12항에 따른 벡터를 포함하는 숙주 세포.

제1항 내지 제9항 중 어느 한 항에 따른 재조합 바이러스-유사 입자를 포함하는 백신.

제14항에 있어서, gpUL75, gpUL115, gpUL128, gpUL130 및 gpUL131A로 이루어진 오량체 복합체를 추가로 포함하는 백신.

제14항 또는 제15항에 있어서, gpUL75, gpUL115, gpUL55, gpUL74, gpUL100, gpUL73, gpUL128, gpUL130 및 gpUL131A로 이루어진 군으로부터 선택된 가용성 CMV 단백질을 추가로 포함하는 백신.

제14항 내지 제16항 중 어느 한 항에 있어서, pUL83, IE-1, pUL99, pUL91, pUL82 및 pp150으로 이루어진 군으로부터 선택된 가용성 CMV 단백질을 추가로 포함하는 백신.

제14항 내지 제17항 중 어느 한 항에 있어서, 타운(Towne), 톨레도(Toledo), AD169, 메를린(Merlin), TB20 및 VR1814 균주의 군으로부터 선택된 상이한 CMV 균주 유래의 CMV 단백질을 포함하는 백신.

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