KR20150035550A - 신경성 장애 치료용 판토테네이트 유도체 - Google Patents

신경성 장애 치료용 판토테네이트 유도체 Download PDF

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Publication number
KR20150035550A
KR20150035550A KR20147033141A KR20147033141A KR20150035550A KR 20150035550 A KR20150035550 A KR 20150035550A KR 20147033141 A KR20147033141 A KR 20147033141A KR 20147033141 A KR20147033141 A KR 20147033141A KR 20150035550 A KR20150035550 A KR 20150035550A
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South Korea
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compound
subject
substituted
unsubstituted
formula
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Abandoned
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KR20147033141A
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English (en)
Korean (ko)
Inventor
앤드류 바이노
마렉 비에스텍
마틴 셔크렐리
Original Assignee
레트로핀, 인코포레이티드
마렉 비에스텍
마틴 셔크렐리
앤드류 바이노
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Publication of KR20150035550A publication Critical patent/KR20150035550A/ko
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/242—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyaryl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/222—Amides of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR20147033141A 2012-04-27 2013-04-26 신경성 장애 치료용 판토테네이트 유도체 Abandoned KR20150035550A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261639602P 2012-04-27 2012-04-27
US61/639,602 2012-04-27
PCT/US2013/038458 WO2013163576A1 (en) 2012-04-27 2013-04-26 Pantothenate derivatives for the treatment of neurologic disorders

Publications (1)

Publication Number Publication Date
KR20150035550A true KR20150035550A (ko) 2015-04-06

Family

ID=48428654

Family Applications (1)

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KR20147033141A Abandoned KR20150035550A (ko) 2012-04-27 2013-04-26 신경성 장애 치료용 판토테네이트 유도체

Country Status (24)

Country Link
US (3) US8673883B2 (enExample)
EP (3) EP3112372B1 (enExample)
JP (3) JP6254151B2 (enExample)
KR (1) KR20150035550A (enExample)
CN (2) CN106977544B (enExample)
AU (3) AU2013251345B2 (enExample)
BR (1) BR112014026817A2 (enExample)
CA (1) CA2879314A1 (enExample)
CY (2) CY1118198T1 (enExample)
DK (2) DK2841438T3 (enExample)
ES (2) ES2708813T3 (enExample)
HR (2) HRP20161389T1 (enExample)
HU (2) HUE042199T2 (enExample)
IN (1) IN2014DN09584A (enExample)
LT (2) LT3112372T (enExample)
MX (1) MX360149B (enExample)
PL (2) PL3112372T3 (enExample)
PT (2) PT3112372T (enExample)
RS (2) RS55319B1 (enExample)
RU (2) RU2653497C2 (enExample)
SI (2) SI3112372T1 (enExample)
SM (2) SMT201900007T1 (enExample)
TR (1) TR201819263T4 (enExample)
WO (1) WO2013163576A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3112372T1 (sl) * 2012-04-27 2019-04-30 Retrophin, Inc. Derivati pantotenata za zdravljenje nevroloških motenj
US9896464B2 (en) 2013-10-25 2018-02-20 Retrophin, Inc. Pantothenate derivatives for the treatment of neurological disorders
EP2868662A1 (en) 2013-11-04 2015-05-06 Acies Bio d.o.o. Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds
EP3386995A1 (en) * 2015-12-08 2018-10-17 Retrophin, Inc. Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders
MX2019009342A (es) * 2017-02-07 2019-10-02 Retrophin Inc Formulaciones de fosmetpantotenato solido.
US12065404B2 (en) 2022-03-18 2024-08-20 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2676976A (en) 1950-12-04 1954-04-27 Nat Res Dev Synthesis of pantothenic acid-4' phosphate
US2870188A (en) 1955-10-03 1959-01-20 Hoffmann La Roche Process for the manufacture of pantothenic acid 4'-phosphate and its salts
RU2002110463A (ru) * 1999-09-21 2004-02-27 Басф Акциенгезелльшафт (De) Способ и микроорганизмы для получения пантосоединений
AU2002326412A1 (en) 2001-07-20 2003-03-03 Oregon Health And Science University Novel human nucleic acids encoding a pantothenate kinase and methods of use
US20060099692A1 (en) * 2002-07-03 2006-05-11 Yocum R R Microorganisms and processes for enhanced production of pantothenate
CN101287472B (zh) 2005-08-15 2011-10-12 弗·哈夫曼-拉罗切有限公司 抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物
SI3112372T1 (sl) * 2012-04-27 2019-04-30 Retrophin, Inc. Derivati pantotenata za zdravljenje nevroloških motenj

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Publication number Publication date
HRP20161389T1 (hr) 2016-12-02
CN104520307A (zh) 2015-04-15
US20160015727A1 (en) 2016-01-21
RS58336B1 (sr) 2019-03-29
SMT201900007T1 (it) 2019-02-28
RU2014147739A (ru) 2016-06-20
LT2841438T (lt) 2016-11-10
RU2653497C2 (ru) 2018-05-10
CN106977544B (zh) 2019-06-07
CA2879314A1 (en) 2013-10-31
AU2017239508C1 (en) 2019-11-07
DK3112372T3 (en) 2019-02-18
US9181286B2 (en) 2015-11-10
AU2013251345B2 (en) 2017-08-31
MX360149B (es) 2018-10-24
RU2018112720A (ru) 2019-02-28
SI2841438T1 (sl) 2016-12-30
EP2841438B1 (en) 2016-08-10
CY1121238T1 (el) 2020-05-29
PT3112372T (pt) 2019-01-17
DK2841438T3 (en) 2016-11-28
EP3489248A1 (en) 2019-05-29
JP2019206553A (ja) 2019-12-05
TR201819263T4 (tr) 2019-01-21
US20130289001A1 (en) 2013-10-31
CY1118198T1 (el) 2017-06-28
JP6560284B2 (ja) 2019-08-14
US20140135294A1 (en) 2014-05-15
JP2015515496A (ja) 2015-05-28
AU2017239508B9 (en) 2019-06-13
ES2600179T3 (es) 2017-02-07
JP6254151B2 (ja) 2017-12-27
US8673883B2 (en) 2014-03-18
MX2014013048A (es) 2015-04-10
US9629862B2 (en) 2017-04-25
RS55319B1 (sr) 2017-03-31
WO2013163576A1 (en) 2013-10-31
EP3112372A1 (en) 2017-01-04
ES2708813T3 (es) 2019-04-11
AU2017239508B2 (en) 2019-05-23
HUE042199T2 (hu) 2019-06-28
IN2014DN09584A (enExample) 2015-07-17
CN104520307B (zh) 2016-12-21
HK1207863A1 (en) 2016-02-12
AU2017239508A1 (en) 2017-10-26
AU2013251345A1 (en) 2014-11-27
BR112014026817A2 (pt) 2017-07-18
SI3112372T1 (sl) 2019-04-30
PT2841438T (pt) 2016-11-22
AU2019219733A1 (en) 2019-09-05
PL3112372T3 (pl) 2019-05-31
CN106977544A (zh) 2017-07-25
LT3112372T (lt) 2019-01-10
JP2017141257A (ja) 2017-08-17
HUE029474T2 (en) 2017-02-28
PL2841438T3 (pl) 2017-08-31
EP2841438A1 (en) 2015-03-04
HRP20190038T1 (hr) 2019-02-22
SMT201600395B (it) 2017-01-10
EP3112372B1 (en) 2018-11-07

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