RS58336B1 - Derivati pantotenata za lečenje neuroloških poremećaja - Google Patents

Derivati pantotenata za lečenje neuroloških poremećaja

Info

Publication number
RS58336B1
RS58336B1 RS20190049A RSP20190049A RS58336B1 RS 58336 B1 RS58336 B1 RS 58336B1 RS 20190049 A RS20190049 A RS 20190049A RS P20190049 A RSP20190049 A RS P20190049A RS 58336 B1 RS58336 B1 RS 58336B1
Authority
RS
Serbia
Prior art keywords
compound
treatment
subject
cells
substituted
Prior art date
Application number
RS20190049A
Other languages
English (en)
Serbian (sr)
Inventor
Andrew Vaino
Marek Biestek
Martin Shkreli
Original Assignee
Retrophin Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Retrophin Inc filed Critical Retrophin Inc
Publication of RS58336B1 publication Critical patent/RS58336B1/sr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2404Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/242Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyaryl compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/222Amides of phosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2454Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings
    • C07F9/5728Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
RS20190049A 2012-04-27 2013-04-26 Derivati pantotenata za lečenje neuroloških poremećaja RS58336B1 (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261639602P 2012-04-27 2012-04-27
EP16001739.8A EP3112372B1 (en) 2012-04-27 2013-04-26 Pantothenate derivatives for the treatment of neurologic disorders

Publications (1)

Publication Number Publication Date
RS58336B1 true RS58336B1 (sr) 2019-03-29

Family

ID=48428654

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20190049A RS58336B1 (sr) 2012-04-27 2013-04-26 Derivati pantotenata za lečenje neuroloških poremećaja
RS20160939A RS55319B1 (sr) 2012-04-27 2013-04-26 Derivati panototenata za lečenje neuroloških poremećaja

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20160939A RS55319B1 (sr) 2012-04-27 2013-04-26 Derivati panototenata za lečenje neuroloških poremećaja

Country Status (24)

Country Link
US (3) US8673883B2 (enExample)
EP (3) EP2841438B1 (enExample)
JP (3) JP6254151B2 (enExample)
KR (1) KR20150035550A (enExample)
CN (2) CN106977544B (enExample)
AU (3) AU2013251345B2 (enExample)
BR (1) BR112014026817A2 (enExample)
CA (1) CA2879314A1 (enExample)
CY (2) CY1118198T1 (enExample)
DK (2) DK3112372T3 (enExample)
ES (2) ES2600179T3 (enExample)
HR (2) HRP20161389T1 (enExample)
HU (2) HUE042199T2 (enExample)
IN (1) IN2014DN09584A (enExample)
LT (2) LT2841438T (enExample)
MX (1) MX360149B (enExample)
PL (2) PL2841438T3 (enExample)
PT (2) PT2841438T (enExample)
RS (2) RS58336B1 (enExample)
RU (2) RU2653497C2 (enExample)
SI (2) SI2841438T1 (enExample)
SM (2) SMT201900007T1 (enExample)
TR (1) TR201819263T4 (enExample)
WO (1) WO2013163576A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2879314A1 (en) * 2012-04-27 2013-10-31 Retrophin, Inc. Pantothenate derivatives for the treatment of neurologic disorders
WO2015061792A1 (en) 2013-10-25 2015-04-30 Retrophin, Inc. Panothenate derivatives for the treatment of neurological disorders
EP2868662A1 (en) 2013-11-04 2015-05-06 Acies Bio d.o.o. Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds
CN108473519A (zh) * 2015-12-08 2018-08-31 雷特罗芬公司 用于治疗神经疾病的环状磷酸酯和环状氨基磷酸酯
MX2019009342A (es) * 2017-02-07 2019-10-02 Retrophin Inc Formulaciones de fosmetpantotenato solido.
US12065404B2 (en) 2022-03-18 2024-08-20 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2676976A (en) 1950-12-04 1954-04-27 Nat Res Dev Synthesis of pantothenic acid-4' phosphate
US2870188A (en) 1955-10-03 1959-01-20 Hoffmann La Roche Process for the manufacture of pantothenic acid 4'-phosphate and its salts
RU2002110463A (ru) * 1999-09-21 2004-02-27 Басф Акциенгезелльшафт (De) Способ и микроорганизмы для получения пантосоединений
WO2003008626A2 (en) 2001-07-20 2003-01-30 Oregon Health And Science University Novel human nucleic acids encoding a pantothenate kinase and methods of use
DK1520030T3 (da) * 2002-07-03 2012-02-27 Basf Se Microorganismer og fremgangsmåder til forøget produktion af pantothenat
CN101287472B (zh) 2005-08-15 2011-10-12 弗·哈夫曼-拉罗切有限公司 抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物
CA2879314A1 (en) * 2012-04-27 2013-10-31 Retrophin, Inc. Pantothenate derivatives for the treatment of neurologic disorders

Also Published As

Publication number Publication date
EP2841438B1 (en) 2016-08-10
EP2841438A1 (en) 2015-03-04
CN104520307A (zh) 2015-04-15
BR112014026817A2 (pt) 2017-07-18
JP6560284B2 (ja) 2019-08-14
SI3112372T1 (sl) 2019-04-30
HK1207863A1 (en) 2016-02-12
EP3112372A1 (en) 2017-01-04
SMT201900007T1 (it) 2019-02-28
CN106977544B (zh) 2019-06-07
JP2015515496A (ja) 2015-05-28
PL2841438T3 (pl) 2017-08-31
JP2017141257A (ja) 2017-08-17
RU2014147739A (ru) 2016-06-20
CY1118198T1 (el) 2017-06-28
US8673883B2 (en) 2014-03-18
SI2841438T1 (sl) 2016-12-30
CN106977544A (zh) 2017-07-25
KR20150035550A (ko) 2015-04-06
US20160015727A1 (en) 2016-01-21
PT3112372T (pt) 2019-01-17
MX2014013048A (es) 2015-04-10
CN104520307B (zh) 2016-12-21
ES2600179T3 (es) 2017-02-07
MX360149B (es) 2018-10-24
CA2879314A1 (en) 2013-10-31
RS55319B1 (sr) 2017-03-31
JP2019206553A (ja) 2019-12-05
HRP20190038T1 (hr) 2019-02-22
LT3112372T (lt) 2019-01-10
LT2841438T (lt) 2016-11-10
CY1121238T1 (el) 2020-05-29
AU2013251345A1 (en) 2014-11-27
AU2017239508B2 (en) 2019-05-23
US9181286B2 (en) 2015-11-10
WO2013163576A1 (en) 2013-10-31
ES2708813T3 (es) 2019-04-11
DK2841438T3 (en) 2016-11-28
PT2841438T (pt) 2016-11-22
AU2017239508C1 (en) 2019-11-07
RU2018112720A (ru) 2019-02-28
SMT201600395B (it) 2017-01-10
EP3489248A1 (en) 2019-05-29
AU2013251345B2 (en) 2017-08-31
US20130289001A1 (en) 2013-10-31
RU2653497C2 (ru) 2018-05-10
US20140135294A1 (en) 2014-05-15
EP3112372B1 (en) 2018-11-07
TR201819263T4 (tr) 2019-01-21
HRP20161389T1 (hr) 2016-12-02
HUE029474T2 (en) 2017-02-28
PL3112372T3 (pl) 2019-05-31
JP6254151B2 (ja) 2017-12-27
AU2019219733A1 (en) 2019-09-05
DK3112372T3 (en) 2019-02-18
AU2017239508A1 (en) 2017-10-26
HUE042199T2 (hu) 2019-06-28
IN2014DN09584A (enExample) 2015-07-17
US9629862B2 (en) 2017-04-25
AU2017239508B9 (en) 2019-06-13

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