KR20140116515A - 금속효소 억제제 화합물 - Google Patents

금속효소 억제제 화합물 Download PDF

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Publication number
KR20140116515A
KR20140116515A KR1020147023021A KR20147023021A KR20140116515A KR 20140116515 A KR20140116515 A KR 20140116515A KR 1020147023021 A KR1020147023021 A KR 1020147023021A KR 20147023021 A KR20147023021 A KR 20147023021A KR 20140116515 A KR20140116515 A KR 20140116515A
Authority
KR
South Korea
Prior art keywords
tetrazol
pyridin
difluoro
difluorophenyl
propan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020147023021A
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English (en)
Korean (ko)
Inventor
윌리암 제이. 헉스트라
로버트 제이. 쇼트징거
스티븐 더블유. 래퍼티
Original Assignee
비아멧 파마슈티컬즈, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by 비아멧 파마슈티컬즈, 인코포레이티드 filed Critical 비아멧 파마슈티컬즈, 인코포레이티드
Publication of KR20140116515A publication Critical patent/KR20140116515A/ko
Withdrawn legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/713Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647Triazoles; Hydrogenated triazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647Triazoles; Hydrogenated triazoles
    • A01N43/6531,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catching Or Destruction (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
KR1020147023021A 2012-01-20 2013-01-18 금속효소 억제제 화합물 Withdrawn KR20140116515A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261589064P 2012-01-20 2012-01-20
US61/589,064 2012-01-20
PCT/US2013/022317 WO2013110002A1 (en) 2012-01-20 2013-01-18 Metalloenzyme inhibitor compounds

Publications (1)

Publication Number Publication Date
KR20140116515A true KR20140116515A (ko) 2014-10-02

Family

ID=48799720

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147023021A Withdrawn KR20140116515A (ko) 2012-01-20 2013-01-18 금속효소 억제제 화합물

Country Status (17)

Country Link
US (1) US9414596B2 (https=)
EP (1) EP2804479A4 (https=)
JP (3) JP2015505538A (https=)
KR (1) KR20140116515A (https=)
CN (1) CN104135861A (https=)
AU (1) AU2013209520A1 (https=)
BR (1) BR112014017799A8 (https=)
CA (1) CA2861341A1 (https=)
CL (1) CL2014001892A1 (https=)
CO (1) CO7111289A2 (https=)
CR (1) CR20140387A (https=)
EA (1) EA201491386A1 (https=)
EC (1) ECSP14014530A (https=)
IN (1) IN2014DN06812A (https=)
MX (1) MX2014008729A (https=)
PH (1) PH12014501653A1 (https=)
WO (1) WO2013110002A1 (https=)

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KR20170129895A (ko) * 2015-03-19 2017-11-27 비아멧 파마슈티컬즈, 인코포레이티드 항진균성 화합물 및 이의 제조 방법

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ES2774267T3 (es) 2012-01-20 2020-07-20 Mycovia Pharmaceuticals Inc Compuestos inhibidores de metaloenzimas
MX378259B (es) 2012-12-28 2025-03-10 Corteva Agriscience Llc Mezclas fungicidas sinérgicas para el control fúngico en cereales.
BR112015015243B8 (pt) 2012-12-31 2022-08-23 Dow Agrosciences Llc Composto contendo picolinamidas macrocíclicas, composição e método para controle e prevenção de doença em planta
WO2015100184A1 (en) 2013-12-26 2015-07-02 Dow Agrosciences Llc Use of macrocyclic picolinamides as fungicides
WO2015100182A1 (en) 2013-12-26 2015-07-02 Dow Agrosciences Llc Use of macrocyclic picolinamides as fungicides
AU2015231226B2 (en) * 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP6633539B2 (ja) 2014-03-19 2020-01-22 ダウ アグロサイエンシィズ エルエルシー 2−(2,4−ジフルオロフェニル)−1,1−ジフルオロ−1−(5−置換−ピリジン−2−イル)−3−(1h−テトラゾール−1−イル)プロパン−2−オールおよびその調製工程
JP6572234B2 (ja) * 2014-03-19 2019-09-04 ヴィアメット ファーマスーティカルズ(エヌシー),インコーポレイテッド 抗真菌化合物の調製方法
CA2942972A1 (en) * 2014-03-19 2015-09-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antifungal compound process
ES2800905T3 (es) * 2014-03-19 2021-01-05 Mycovia Pharmaceuticals Inc Procedimiento para compuesto antifúngico
BR112016021257B1 (pt) * 2014-03-19 2021-03-02 Viamet Pharmaceuticals (NC), Inc. 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos
JP2017512777A (ja) * 2014-03-19 2017-05-25 ヴィアメット ファーマスーティカルズ,インコーポレイテッド 抗真菌化合物の調製方法
CA2942936A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
AU2015231275B2 (en) * 2014-03-19 2019-03-07 Mycovia Pharmaceuticals, Inc. Antifungal compound process
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JP6532480B2 (ja) * 2014-04-15 2019-06-19 ダウ アグロサイエンシィズ エルエルシー 殺真菌剤としての金属酵素阻害剤化合物
US9944664B2 (en) * 2014-04-15 2018-04-17 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
US9700047B2 (en) 2014-05-06 2017-07-11 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
EP3166936A4 (en) 2014-07-08 2017-11-22 Dow AgroSciences LLC Macrocyclic picolinamides as fungicides
US9686984B2 (en) 2014-07-08 2017-06-27 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
KR20170099928A (ko) 2014-12-30 2017-09-01 다우 아그로사이언시즈 엘엘씨 살진균 활성을 갖는 피콜린아미드
JP6687625B2 (ja) 2014-12-30 2020-04-22 ダウ アグロサイエンシィズ エルエルシー 殺真菌活性を有するピコリンアミド化合物
US20180000084A1 (en) 2014-12-30 2018-01-04 Dow Agrosciences Llc Use of picolinamide compounds with fungicidal activity
RU2687160C2 (ru) 2014-12-30 2019-05-07 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пиколинамидные соединения с фунгицидной активностью
TWI700036B (zh) 2014-12-30 2020-08-01 美商陶氏農業科學公司 殺真菌組成物(一)
NZ732812A (en) 2014-12-30 2019-01-25 Dow Agrosciences Llc Use of picolinamides and other compounds as fungicides
JP6847458B2 (ja) 2015-09-18 2021-03-24 マイコヴィア ファーマシューティカルズ,インコーポレイテッド 抗真菌化合物のプロセス
KR102240920B1 (ko) * 2015-12-30 2021-04-16 브이피에스-3, 엘엘씨 금속 효소 억제 화합물
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US20200045967A1 (en) * 2017-02-08 2020-02-13 Bayer Cropscience Aktiengesellschaft Novel triazole derivatives
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KR102659552B1 (ko) 2017-05-02 2024-04-23 코르테바 애그리사이언스 엘엘씨 잔디풀 상의 진균 질환에 대한 살진균제로서의 비고리형 피콜린아미드 화합물의 용도
TW201842851A (zh) 2017-05-02 2018-12-16 美商陶氏農業科學公司 用於穀類中的真菌防治之協同性混合物
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KR20170129895A (ko) * 2015-03-19 2017-11-27 비아멧 파마슈티컬즈, 인코포레이티드 항진균성 화합물 및 이의 제조 방법

Also Published As

Publication number Publication date
JP2015505538A (ja) 2015-02-23
JP2019116476A (ja) 2019-07-18
EP2804479A4 (en) 2015-07-22
WO2013110002A1 (en) 2013-07-25
JP2017110004A (ja) 2017-06-22
US20150024938A1 (en) 2015-01-22
IN2014DN06812A (https=) 2015-05-22
ECSP14014530A (es) 2015-06-30
CR20140387A (es) 2014-11-27
CO7111289A2 (es) 2014-11-10
PH12014501653A1 (en) 2014-10-13
EP2804479A1 (en) 2014-11-26
CN104135861A (zh) 2014-11-05
BR112014017799A8 (pt) 2017-07-11
AU2013209520A1 (en) 2014-08-28
CA2861341A1 (en) 2013-07-25
BR112014017799A2 (https=) 2017-06-20
EA201491386A1 (ru) 2014-11-28
US9414596B2 (en) 2016-08-16
CL2014001892A1 (es) 2014-11-14
MX2014008729A (es) 2015-02-04

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Date Code Title Description
PA0105 International application

Patent event date: 20140818

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid