CN104135861A - 金属酶抑制剂化合物 - Google Patents

金属酶抑制剂化合物 Download PDF

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Publication number
CN104135861A
CN104135861A CN201380010205.1A CN201380010205A CN104135861A CN 104135861 A CN104135861 A CN 104135861A CN 201380010205 A CN201380010205 A CN 201380010205A CN 104135861 A CN104135861 A CN 104135861A
Authority
CN
China
Prior art keywords
difluorophenyl
difluoro
pyridin
propan
tetrazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380010205.1A
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English (en)
Chinese (zh)
Inventor
W·J·胡克斯特拉
R·J·肖茨英格尔
S·W·拉弗蒂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mycovia Pharmaceuticals Inc
Original Assignee
Viamet Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Inc filed Critical Viamet Pharmaceuticals Inc
Publication of CN104135861A publication Critical patent/CN104135861A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/713—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catching Or Destruction (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
CN201380010205.1A 2012-01-20 2013-01-18 金属酶抑制剂化合物 Pending CN104135861A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261589064P 2012-01-20 2012-01-20
US61/589,064 2012-01-20
PCT/US2013/022317 WO2013110002A1 (en) 2012-01-20 2013-01-18 Metalloenzyme inhibitor compounds

Publications (1)

Publication Number Publication Date
CN104135861A true CN104135861A (zh) 2014-11-05

Family

ID=48799720

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380010205.1A Pending CN104135861A (zh) 2012-01-20 2013-01-18 金属酶抑制剂化合物

Country Status (17)

Country Link
US (1) US9414596B2 (https=)
EP (1) EP2804479A4 (https=)
JP (3) JP2015505538A (https=)
KR (1) KR20140116515A (https=)
CN (1) CN104135861A (https=)
AU (1) AU2013209520A1 (https=)
BR (1) BR112014017799A8 (https=)
CA (1) CA2861341A1 (https=)
CL (1) CL2014001892A1 (https=)
CO (1) CO7111289A2 (https=)
CR (1) CR20140387A (https=)
EA (1) EA201491386A1 (https=)
EC (1) ECSP14014530A (https=)
IN (1) IN2014DN06812A (https=)
MX (1) MX2014008729A (https=)
PH (1) PH12014501653A1 (https=)
WO (1) WO2013110002A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107428724A (zh) * 2015-03-19 2017-12-01 维亚梅特制药公司 抗真菌化合物及制备方法
CN108779094A (zh) * 2015-12-30 2018-11-09 Vps-3有限公司 金属酶抑制剂化合物
CN110981810A (zh) * 2019-12-19 2020-04-10 东莞市维琪科技有限公司 一种脱羧肌肽的合成方法
WO2021143811A1 (zh) * 2020-01-17 2021-07-22 上海森辉医药有限公司 四氮唑类化合物的可药用盐及其结晶形式、制备方法和用途

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PT3153020T (pt) 2009-10-07 2019-02-26 Dow Agrosciences Llc Misturas fungicidas sinérgicas para o controlo de fungos em cereais
EA025266B1 (ru) * 2011-06-23 2016-12-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
ES2774267T3 (es) 2012-01-20 2020-07-20 Mycovia Pharmaceuticals Inc Compuestos inhibidores de metaloenzimas
MX378259B (es) 2012-12-28 2025-03-10 Corteva Agriscience Llc Mezclas fungicidas sinérgicas para el control fúngico en cereales.
BR112015015243B8 (pt) 2012-12-31 2022-08-23 Dow Agrosciences Llc Composto contendo picolinamidas macrocíclicas, composição e método para controle e prevenção de doença em planta
WO2015100184A1 (en) 2013-12-26 2015-07-02 Dow Agrosciences Llc Use of macrocyclic picolinamides as fungicides
WO2015100182A1 (en) 2013-12-26 2015-07-02 Dow Agrosciences Llc Use of macrocyclic picolinamides as fungicides
AU2015231226B2 (en) * 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP6633539B2 (ja) 2014-03-19 2020-01-22 ダウ アグロサイエンシィズ エルエルシー ２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−１−（５−置換−ピリジン−２−イル）−３−（１ｈ−テトラゾール−１−イル）プロパン−２−オールおよびその調製工程
JP6572234B2 (ja) * 2014-03-19 2019-09-04 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 抗真菌化合物の調製方法
CA2942972A1 (en) * 2014-03-19 2015-09-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antifungal compound process
ES2800905T3 (es) * 2014-03-19 2021-01-05 Mycovia Pharmaceuticals Inc Procedimiento para compuesto antifúngico
BR112016021257B1 (pt) * 2014-03-19 2021-03-02 Viamet Pharmaceuticals (NC), Inc. 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos
JP2017512777A (ja) * 2014-03-19 2017-05-25 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
CA2942936A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
AU2015231275B2 (en) * 2014-03-19 2019-03-07 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA2942231A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
JP6532480B2 (ja) * 2014-04-15 2019-06-19 ダウ アグロサイエンシィズ エルエルシー 殺真菌剤としての金属酵素阻害剤化合物
US9944664B2 (en) * 2014-04-15 2018-04-17 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
US9700047B2 (en) 2014-05-06 2017-07-11 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
EP3166936A4 (en) 2014-07-08 2017-11-22 Dow AgroSciences LLC Macrocyclic picolinamides as fungicides
US9686984B2 (en) 2014-07-08 2017-06-27 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
KR20170099928A (ko) 2014-12-30 2017-09-01 다우 아그로사이언시즈 엘엘씨 살진균 활성을 갖는 피콜린아미드
JP6687625B2 (ja) 2014-12-30 2020-04-22 ダウ アグロサイエンシィズ エルエルシー 殺真菌活性を有するピコリンアミド化合物
US20180000084A1 (en) 2014-12-30 2018-01-04 Dow Agrosciences Llc Use of picolinamide compounds with fungicidal activity
RU2687160C2 (ru) 2014-12-30 2019-05-07 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пиколинамидные соединения с фунгицидной активностью
TWI700036B (zh) 2014-12-30 2020-08-01 美商陶氏農業科學公司 殺真菌組成物（一）
NZ732812A (en) 2014-12-30 2019-01-25 Dow Agrosciences Llc Use of picolinamides and other compounds as fungicides
JP6847458B2 (ja) 2015-09-18 2021-03-24 マイコヴィア ファーマシューティカルズ，インコーポレイテッド 抗真菌化合物のプロセス
WO2018045000A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Picolinamides as fungicides
US10111432B2 (en) 2016-08-30 2018-10-30 Dow Agrosciences Llc Picolinamide N-oxide compounds with fungicidal activity
WO2018045012A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Pyrido-1,3-oxazine-2,4-dione compounds with fungicidal activity
US10172358B2 (en) 2016-08-30 2019-01-08 Dow Agrosciences Llc Thiopicolinamide compounds with fungicidal activity
BR102018000183B1 (pt) 2017-01-05 2023-04-25 Dow Agrosciences Llc Picolinamidas, composição para controle de um patógeno fúngico, e método para controle e prevenção de um ataque por fungos em uma planta
US20200045967A1 (en) * 2017-02-08 2020-02-13 Bayer Cropscience Aktiengesellschaft Novel triazole derivatives
TWI774761B (zh) 2017-05-02 2022-08-21 美商科迪華農業科技有限責任公司 用於穀物中的真菌防治之協同性混合物
KR102659552B1 (ko) 2017-05-02 2024-04-23 코르테바 애그리사이언스 엘엘씨 잔디풀 상의 진균 질환에 대한 살진균제로서의 비고리형 피콜린아미드 화합물의 용도
TW201842851A (zh) 2017-05-02 2018-12-16 美商陶氏農業科學公司 用於穀類中的真菌防治之協同性混合物
BR102019004480B1 (pt) 2018-03-08 2023-03-28 Dow Agrosciences Llc Picolinamidas como fungicidas
CA3115684A1 (en) 2018-10-15 2020-04-23 Dow Agrosciences Llc Methods for sythesis of oxypicolinamides
US12281076B2 (en) 2019-10-18 2025-04-22 Corteva Agriscience Llc Process for synthesis of picolinamides
WO2026006142A1 (en) * 2024-06-24 2026-01-02 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Azole compounds useful as inhibitors of voltage-dependent anion channel oligomerization

Citations (4)

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Publication number Priority date Publication date Assignee Title
EP0117100A1 (en) * 1983-02-16 1984-08-29 Pfizer Limited Triazole antifungal agents
CN1187756A (zh) * 1995-06-16 1998-07-15 诺瓦提斯公司 保护作物的组合物
CN102143689A (zh) * 2008-09-03 2011-08-03 拜尔农作物科学股份公司 杀真菌化合物组合物用于控制某些锈菌类的用途
US20110306644A1 (en) * 2010-04-24 2011-12-15 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds

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GB8304282D0 (en) * 1983-02-16 1983-03-23 Pfizer Ltd Antifungal agents
US5358939A (en) * 1992-06-25 1994-10-25 Rohm And Haas Company Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles
MY115814A (en) 1995-06-16 2003-09-30 Bayer Ip Gmbh Crop protection compositions
JP2006143593A (ja) * 2004-11-16 2006-06-08 Hokko Chem Ind Co Ltd Ｎ−ベンジルテトラゾール誘導体および農園芸用殺菌剤
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117100A1 (en) * 1983-02-16 1984-08-29 Pfizer Limited Triazole antifungal agents
CN1187756A (zh) * 1995-06-16 1998-07-15 诺瓦提斯公司 保护作物的组合物
CN102143689A (zh) * 2008-09-03 2011-08-03 拜尔农作物科学股份公司 杀真菌化合物组合物用于控制某些锈菌类的用途
US20110306644A1 (en) * 2010-04-24 2011-12-15 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107428724A (zh) * 2015-03-19 2017-12-01 维亚梅特制药公司 抗真菌化合物及制备方法
CN107428724B (zh) * 2015-03-19 2021-07-02 迈科维亚医药公司 抗真菌化合物及制备方法
CN108779094A (zh) * 2015-12-30 2018-11-09 Vps-3有限公司 金属酶抑制剂化合物
CN108779094B (zh) * 2015-12-30 2021-11-16 Nqp 1598公司 金属酶抑制剂化合物
CN110981810A (zh) * 2019-12-19 2020-04-10 东莞市维琪科技有限公司 一种脱羧肌肽的合成方法
WO2021143811A1 (zh) * 2020-01-17 2021-07-22 上海森辉医药有限公司 四氮唑类化合物的可药用盐及其结晶形式、制备方法和用途

Also Published As

Publication number Publication date
JP2015505538A (ja) 2015-02-23
JP2019116476A (ja) 2019-07-18
EP2804479A4 (en) 2015-07-22
WO2013110002A1 (en) 2013-07-25
JP2017110004A (ja) 2017-06-22
US20150024938A1 (en) 2015-01-22
IN2014DN06812A (https=) 2015-05-22
ECSP14014530A (es) 2015-06-30
CR20140387A (es) 2014-11-27
CO7111289A2 (es) 2014-11-10
PH12014501653A1 (en) 2014-10-13
EP2804479A1 (en) 2014-11-26
BR112014017799A8 (pt) 2017-07-11
AU2013209520A1 (en) 2014-08-28
CA2861341A1 (en) 2013-07-25
BR112014017799A2 (https=) 2017-06-20
KR20140116515A (ko) 2014-10-02
EA201491386A1 (ru) 2014-11-28
US9414596B2 (en) 2016-08-16
CL2014001892A1 (es) 2014-11-14
MX2014008729A (es) 2015-02-04

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Application publication date: 20141105