KR20140107340A - 당뇨병과 같은 치료를 위한 glp-1 수용체 조절제로서 작용하는 4 개의 사이클을 포함하는 카르복실산 유도체 - Google Patents

당뇨병과 같은 치료를 위한 glp-1 수용체 조절제로서 작용하는 4 개의 사이클을 포함하는 카르복실산 유도체 Download PDF

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KR20140107340A
KR20140107340A KR1020147017945A KR20147017945A KR20140107340A KR 20140107340 A KR20140107340 A KR 20140107340A KR 1020147017945 A KR1020147017945 A KR 1020147017945A KR 20147017945 A KR20147017945 A KR 20147017945A KR 20140107340 A KR20140107340 A KR 20140107340A
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phenyl
tert
mmol
butyl
compound
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마르쿠스 에프. 보엠
에스더 마틴버러
마니샤 무르자니
준코 타미야
리밍 후앙
아담 알. 예거
에누구르티 브라흐마차리
토마스 파울러
앤드류 노박
프렘지 메가니
마이클 낙스
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레셉토스, 인코포레이티드
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KR1020147017945A 2011-12-12 2012-12-12 당뇨병과 같은 치료를 위한 glp-1 수용체 조절제로서 작용하는 4 개의 사이클을 포함하는 카르복실산 유도체 Withdrawn KR20140107340A (ko)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170102487A (ko) * 2014-12-10 2017-09-11 셀진 인터내셔널 Ii 에스에이알엘 Glp-1 수용체 조절제

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8501982B2 (en) 2010-06-09 2013-08-06 Receptos, Inc. GLP-1 receptor stabilizers and modulators
DK2713722T3 (en) 2011-05-31 2017-07-03 Celgene Int Ii Sarl Newly known GLP-1 receptor stabilizers and modulators
HK1202119A1 (en) 2011-12-12 2015-09-18 Celgene International Ii Sàrl Novel glp-1 receptor modulators
CN105593225B (zh) * 2013-06-11 2019-04-16 赛尔基因第二国际有限公司 新型glp-1受体调节剂
CN107074820B (zh) 2014-07-25 2021-05-18 赛尔基因第二国际有限公司 Glp-1受体调节剂
KR102414503B1 (ko) 2016-03-17 2022-06-29 티오제네시스 테라퓨틱스, 인크. 시스테아민의 조절 방출을 위한 조성물 및 시스테아민 민감성 장애의 전신 치료
CA3021994A1 (en) 2016-05-06 2017-11-09 Brett P. Monia Glp-1 receptor ligand moiety conjugated oligonucleotides and uses thereof
CN114539273A (zh) 2016-06-07 2022-05-27 北京加科思新药研发有限公司 可用作shp2抑制剂的新型杂环衍生物
HRP20241239T1 (hr) 2017-03-23 2024-12-06 Jacobio Pharmaceuticals Co., Ltd. Novi heterociklički derivati korisni kao shp2 inhibitori
WO2018200833A1 (en) * 2017-04-28 2018-11-01 Celgene International Ii Sarl Novel glp-1 receptor modulators
US11612576B2 (en) 2017-09-20 2023-03-28 Thiogenesis Therapeutics, Inc. Methods for the treatment of cysteamine sensitive disorders
WO2020063760A1 (en) 2018-09-26 2020-04-02 Jacobio Pharmaceuticals Co., Ltd. Novel heterocyclic derivatives useful as shp2 inhibitors
CU20210042A7 (es) 2018-11-22 2022-01-13 Qilu Regor Therapeutics Inc Compuestos agonistas de glp-1r y composiciones farmacéuticas que lo contienen
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
US20220193080A1 (en) * 2019-04-11 2022-06-23 University Of The Sciences Allosteric agonists and positive allosteric modulators of glucagon-like peptide 1 receptor
US10954221B2 (en) 2019-04-12 2021-03-23 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
CR20210562A (es) 2019-04-12 2022-02-18 Qilu Regor Therapeutics Inc Agonistas de glp-1r y usos de los mismos
CN112521501A (zh) * 2019-09-18 2021-03-19 鸿运华宁（杭州）生物医药有限公司 Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
PH12022550932A1 (en) 2019-10-25 2023-06-14 Gilead Sciences Inc Glp-1r modulating compounds
ES3029360T3 (en) * 2019-11-15 2025-06-24 Ildong Pharmaceutical Co Ltd Glp-1 receptor agonist and use thereof
PE20230175A1 (es) * 2020-03-18 2023-02-01 Lg Chemical Ltd Agonista del receptor de glp-1, composicion farmaceutica que comprende el mismo, y metodo para preparar el mismo
CN113773310B (zh) * 2020-06-10 2023-12-22 重庆康丁医药技术有限公司 一种具有心血管益处的glp-1小分子
WO2022109182A1 (en) 2020-11-20 2022-05-27 Gilead Sciences, Inc. Polyheterocyclic glp-1 r modulating compounds
US20240246959A1 (en) 2020-11-27 2024-07-25 Shenzhen Salubris Pharmaceuticals Co., Ltd. Benzimidazole derivative and preparation method therefor and medical use thereof
TW202521533A (zh) 2023-09-14 2025-06-01 香港商歌禮製藥(中國)有限公司 Glp-1r 激動劑及其治療方法
WO2025109387A1 (en) 2023-11-24 2025-05-30 Ascletis Pharma (China) Co., Limited Glp-1r agonist and therapeutic method thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1062206B (it) 1974-02-01 1983-09-20 Rotta Research Lab S P A A S Derivati della tirosina attivi sulla muscolatura liscia
DE2423536A1 (de) 1974-05-15 1975-11-27 Bayer Ag 3-amino-phenylessigsaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
DE69831673C5 (de) 1997-01-07 2015-01-22 Amylin Pharmaceuticals, Llc Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme
JP2001512139A (ja) * 1997-07-31 2001-08-21 エラン・ファーマシューティカルズ・インコーポレーテッド Ｖｌａ−４が介在する白血球接着を阻害するスルホニル化ジペプチド化合物
US6583139B1 (en) * 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
DK1005445T3 (da) 1997-08-22 2004-10-04 Hoffmann La Roche N-alkanoylphenylaninderivater
US6191171B1 (en) 1997-11-20 2001-02-20 Merck & Co., Inc. Para-aminomethylaryl carboxamide derivatives
DK1137666T5 (da) 1998-12-07 2009-10-05 Univ Tulane GLP-1-analoger
BRPI0007820B8 (pt) 1999-01-14 2021-05-25 Amylin Pharmaceuticals Llc formulações farmacêuticas agonistas de exendina e seus usos
EP1150565A1 (en) * 1999-02-08 2001-11-07 LION bioscience AG Thiazole derivatives and combinatorial libraries thereof
WO2001066531A1 (de) 2000-03-07 2001-09-13 Aventis Pharma Deutschland Gmbh Substituierte 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one (und) ihre verwendung zur hemmung der hormonsensitiven lipase
AU2001290303A1 (en) * 2000-09-29 2002-04-15 Ajinomoto Co., Inc. Novel phenylalanine derivatives
AU2002350217A1 (en) 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
EP1477482B1 (en) * 2002-02-20 2010-04-14 Ajinomoto Co., Inc. Novel phenylalanine derivative
JPWO2003089410A1 (ja) * 2002-04-19 2005-08-25 協和醗酵工業株式会社 フェニルアラニン誘導体
EP1700850B1 (en) * 2003-12-22 2015-07-15 Ajinomoto Co., Inc. Phenylalanine derivative
EP1720839A1 (en) * 2004-02-10 2006-11-15 Janssen Pharmaceutica N.V. Pyridazinones as antagonists of a4 integrins
US7825139B2 (en) 2005-05-25 2010-11-02 Forest Laboratories Holdings Limited (BM) Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US8618324B2 (en) 2007-03-13 2013-12-31 Board Of Regents, The University Of Texas System Composition and method for making oligo-benzamide compounds
WO2008149382A1 (en) 2007-06-08 2008-12-11 Advinus Therapeutics Private Limited Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application
WO2011094890A1 (en) * 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
US8501982B2 (en) 2010-06-09 2013-08-06 Receptos, Inc. GLP-1 receptor stabilizers and modulators
DK2713722T3 (en) 2011-05-31 2017-07-03 Celgene Int Ii Sarl Newly known GLP-1 receptor stabilizers and modulators
EP3422585B1 (en) 2011-06-01 2021-11-10 CommScope Technologies LLC Broadband distributed antenna system with non-duplexer isolator sub-system
HK1202119A1 (en) 2011-12-12 2015-09-18 Celgene International Ii Sàrl Novel glp-1 receptor modulators
CN105593225B (zh) 2013-06-11 2019-04-16 赛尔基因第二国际有限公司 新型glp-1受体调节剂

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170102487A (ko) * 2014-12-10 2017-09-11 셀진 인터내셔널 Ii 에스에이알엘 Glp-1 수용체 조절제

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