KR20140071358A - 생식선기능저하증 및 관련 질환의 치료를 위한 아로마타제 억제제의 용도 - Google Patents

생식선기능저하증 및 관련 질환의 치료를 위한 아로마타제 억제제의 용도 Download PDF

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Publication number
KR20140071358A
KR20140071358A KR1020147006170A KR20147006170A KR20140071358A KR 20140071358 A KR20140071358 A KR 20140071358A KR 1020147006170 A KR1020147006170 A KR 1020147006170A KR 20147006170 A KR20147006170 A KR 20147006170A KR 20140071358 A KR20140071358 A KR 20140071358A
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once
methylene
fluoro
bisbenzonitrile
triazol
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Ceased
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KR1020147006170A
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English (en)
Korean (ko)
Inventor
앤 테일러
로이드 비. 클릭스테인
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노파르티스 아게
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46846026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20140071358(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20140071358A publication Critical patent/KR20140071358A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020147006170A 2011-09-08 2012-09-06 생식선기능저하증 및 관련 질환의 치료를 위한 아로마타제 억제제의 용도 Ceased KR20140071358A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161532459P 2011-09-08 2011-09-08
US61/532,459 2011-09-08
US201261638588P 2012-04-26 2012-04-26
US61/638,588 2012-04-26
PCT/US2012/053844 WO2013036562A1 (en) 2011-09-08 2012-09-06 Use of an aromatase inhibitor for the treatment of hypogonadism and related diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020187007058A Division KR20180030254A (ko) 2011-09-08 2012-09-06 생식선기능저하증 및 관련 질환의 치료를 위한 아로마타제 억제제의 용도

Publications (1)

Publication Number Publication Date
KR20140071358A true KR20140071358A (ko) 2014-06-11

Family

ID=46846026

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020147006170A Ceased KR20140071358A (ko) 2011-09-08 2012-09-06 생식선기능저하증 및 관련 질환의 치료를 위한 아로마타제 억제제의 용도
KR1020187007058A Ceased KR20180030254A (ko) 2011-09-08 2012-09-06 생식선기능저하증 및 관련 질환의 치료를 위한 아로마타제 억제제의 용도
KR1020147006171A Active KR101872561B1 (ko) 2011-09-08 2012-09-06 아로마타제 억제제를 포함하는 제약 조성물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020187007058A Ceased KR20180030254A (ko) 2011-09-08 2012-09-06 생식선기능저하증 및 관련 질환의 치료를 위한 아로마타제 억제제의 용도
KR1020147006171A Active KR101872561B1 (ko) 2011-09-08 2012-09-06 아로마타제 억제제를 포함하는 제약 조성물

Country Status (31)

Country Link
US (4) US9295668B2 (enExample)
EP (2) EP2753313B1 (enExample)
JP (2) JP6051467B2 (enExample)
KR (3) KR20140071358A (enExample)
CN (2) CN103796644B (enExample)
AR (1) AR087790A1 (enExample)
AU (2) AU2012304694B2 (enExample)
BR (2) BR112014005434B1 (enExample)
CA (2) CA2846884C (enExample)
CL (1) CL2014000552A1 (enExample)
CY (2) CY1118461T1 (enExample)
DK (2) DK2753312T3 (enExample)
ES (2) ES2613667T3 (enExample)
HR (2) HRP20170003T1 (enExample)
HU (2) HUE031478T2 (enExample)
IL (1) IL231234A (enExample)
IN (1) IN2014DN01619A (enExample)
LT (2) LT2753312T (enExample)
MX (2) MX343902B (enExample)
PE (1) PE20141584A1 (enExample)
PH (1) PH12014500435A1 (enExample)
PL (2) PL2753313T3 (enExample)
PT (2) PT2753313T (enExample)
RU (2) RU2617510C2 (enExample)
SG (2) SG2014012132A (enExample)
SI (2) SI2753312T1 (enExample)
TN (1) TN2014000059A1 (enExample)
TW (1) TW201316987A (enExample)
UY (1) UY34315A (enExample)
WO (2) WO2013036562A1 (enExample)
ZA (1) ZA201401040B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2753312T1 (sl) * 2011-09-08 2017-10-30 Mereo Biopharma 2 Limited Uporaba inhibitorja aromataze za zdravljenje hipogonadizma in sororodnih bolezni
WO2015148549A1 (en) * 2014-03-26 2015-10-01 The Regents Of The University Of California Ultrasensitive androgen receptor bioassay
PT3166596T (pt) * 2014-07-07 2018-10-19 Novartis Ag Formas farmacêuticas
GB201614179D0 (en) * 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
JP2020510027A (ja) * 2017-03-08 2020-04-02 アリアド ファーマシューティカルズ,インコーポレーテッド 5−クロロ−n4−[2−(ジメチルホスホリル)フェニル]−n2−{2−メトキシ−4−[4−(4−メチルピペラジン−1−イル)ピペリジン−1−イル]フェニル}ピリミジン−2,4−ジアミンを含む医薬製剤
CA3078652A1 (en) 2017-10-12 2019-04-18 Novo Nordisk A/S Semaglutide in medical therapy
USD894149S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
USD894148S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
JP7121999B2 (ja) * 2019-09-26 2022-08-19 学校法人九州文化学園 男性性腺機能低下症治療剤
US12552754B1 (en) 2025-06-11 2026-02-17 ReproNovo SA Leflutrozole compositions of matter and processes for preparation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749713A (en) 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
TW210334B (enExample) * 1990-12-12 1993-08-01 Ciba Geigy Ag
DE4435368A1 (de) * 1994-09-22 1996-03-28 Schering Ag Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
US5972921A (en) * 1997-12-12 1999-10-26 Hormos Medical Oy Ltd. Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
AU2001271162A1 (en) * 2000-07-05 2002-01-14 Astrazeneca Ab Pharmaceutical combination of an anti-androgen and letrozole for providing an anit-androgenic effect and aromatase inhibition
SK14252003A3 (sk) 2001-04-17 2004-03-02 Ares Trading S. A. Použitie aromatázového inhibítora, farmaceutický prostriedok s obsahom aromatázového inhibítora a farmaceutické balenie
US7101573B2 (en) * 2001-09-28 2006-09-05 Mcneil-Pcc, Inc. Simethicone solid oral dosage form
AU2003213957A1 (en) 2002-04-03 2003-10-13 Jencap Research Ltd. Pharmaceutical composition comprising an aromatase inhibitor and an estrogen suitable for hormone replacement therapy for a male
WO2006114702A2 (en) 2005-04-25 2006-11-02 Pfizer Products Inc. Pharmaceutical compositions and methods comprising a combination of a selective estrogen receptor modulator and an aromatase inhibitor
CN102335219A (zh) * 2007-11-21 2012-02-01 客乐谐制药株式会社 芳香酶抑制剂
SI2753312T1 (sl) * 2011-09-08 2017-10-30 Mereo Biopharma 2 Limited Uporaba inhibitorja aromataze za zdravljenje hipogonadizma in sororodnih bolezni

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JP6280501B2 (ja) 2018-02-14
US20140213622A1 (en) 2014-07-31
PT2753312T (pt) 2017-02-03
US20140309267A1 (en) 2014-10-16
DK2753313T3 (en) 2017-02-13
AU2012304694A1 (en) 2014-03-20
HRP20170003T1 (hr) 2017-03-10
US9295668B2 (en) 2016-03-29
LT2753312T (lt) 2017-01-25
CY1118461T1 (el) 2017-07-12
ZA201401040B (en) 2015-12-23
CL2014000552A1 (es) 2014-09-12
CA2846884C (en) 2019-04-09
CA2845929A1 (en) 2013-03-14
SG2014012132A (en) 2014-06-27
BR112014004879A2 (pt) 2017-03-14
TW201316987A (zh) 2013-05-01
JP2014526465A (ja) 2014-10-06
RU2014113334A (ru) 2015-10-20
PH12014500435A1 (en) 2019-03-22
RU2014113575A (ru) 2015-10-20
EP2753312A1 (en) 2014-07-16
DK2753312T3 (da) 2017-02-13
CN103796644A (zh) 2014-05-14
CN103796644B (zh) 2017-05-03
US9370505B2 (en) 2016-06-21
CY1118499T1 (el) 2017-07-12
WO2013036562A1 (en) 2013-03-14
IL231234A0 (en) 2014-04-30
WO2013036563A1 (en) 2013-03-14
AU2012304694B2 (en) 2016-04-07
SG10201607503WA (en) 2016-10-28
AU2012304693A1 (en) 2014-03-13
BR112014005434B1 (pt) 2021-01-05
US20160346257A1 (en) 2016-12-01
KR101872561B1 (ko) 2018-06-28
PT2753313T (pt) 2017-02-02
IL231234A (en) 2016-12-29
CN103781476A (zh) 2014-05-07
RU2628808C2 (ru) 2017-08-22
CA2845929C (en) 2018-06-19
LT2753313T (lt) 2017-02-10
SI2753312T1 (sl) 2017-10-30
IN2014DN01619A (enExample) 2015-05-15
US10064844B2 (en) 2018-09-04
JP6051467B2 (ja) 2016-12-27
PL2753313T3 (pl) 2017-07-31
HRP20170002T1 (hr) 2017-02-24
EP2753312B1 (en) 2016-12-14
MX360315B (es) 2018-10-29
AR087790A1 (es) 2014-04-16
US9750724B2 (en) 2017-09-05
ES2613667T3 (es) 2017-05-25
HUE031478T2 (hu) 2017-07-28
ES2613666T3 (es) 2017-05-25
JP2014528932A (ja) 2014-10-30
MX2014002773A (es) 2014-06-05
CA2846884A1 (en) 2013-03-14
BR112014005434A2 (pt) 2017-04-04
MX343902B (es) 2016-11-28
RU2617510C2 (ru) 2017-04-25
KR20140058619A (ko) 2014-05-14
MX2014002780A (es) 2014-06-05
NZ621476A (en) 2016-02-26
PE20141584A1 (es) 2014-11-13
HUE031435T2 (en) 2017-07-28
BR112014004879B1 (pt) 2020-01-28
US20160243084A1 (en) 2016-08-25
EP2753313B1 (en) 2016-12-14
EP2753313A1 (en) 2014-07-16
CN103781476B (zh) 2016-12-07
UY34315A (es) 2013-04-30
TN2014000059A1 (en) 2015-07-01
SI2753313T1 (sl) 2017-04-26
AU2012304693B2 (en) 2016-03-31
KR20180030254A (ko) 2018-03-21
PL2753312T3 (pl) 2017-06-30

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