BR112014005434B1 - Composições farmacêuticas compreendendo inibidor da aromatase 4,4'-[fluoro-(1h-1,2,4triazol-1-il)metilemo]bisbenzonitrila e seu método de preparação - Google Patents

Composições farmacêuticas compreendendo inibidor da aromatase 4,4'-[fluoro-(1h-1,2,4triazol-1-il)metilemo]bisbenzonitrila e seu método de preparação Download PDF

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Publication number
BR112014005434B1
BR112014005434B1 BR112014005434-7A BR112014005434A BR112014005434B1 BR 112014005434 B1 BR112014005434 B1 BR 112014005434B1 BR 112014005434 A BR112014005434 A BR 112014005434A BR 112014005434 B1 BR112014005434 B1 BR 112014005434B1
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BR
Brazil
Prior art keywords
mixture
approximately
fluoro
pharmaceutical composition
lubricant
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BR112014005434-7A
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English (en)
Portuguese (pt)
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BR112014005434A2 (pt
Inventor
Ann Taylor
Lloyd B. Klickstein
Jeewan Thakur
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Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46846026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014005434(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112014005434A2 publication Critical patent/BR112014005434A2/pt
Publication of BR112014005434B1 publication Critical patent/BR112014005434B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833Encapsulating processes; Filling of capsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06Anabolic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112014005434-7A 2011-09-08 2012-09-06 Composições farmacêuticas compreendendo inibidor da aromatase 4,4'-[fluoro-(1h-1,2,4triazol-1-il)metilemo]bisbenzonitrila e seu método de preparação BR112014005434B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161532459P 2011-09-08 2011-09-08
US61/532,459 2011-09-08
US201261638588P 2012-04-26 2012-04-26
US61/638,588 2012-04-26
PCT/US2012/053846 WO2013036563A1 (en) 2011-09-08 2012-09-06 Pharmaceutical compositions comprising an aromatase inhibitor

Publications (2)

Publication Number Publication Date
BR112014005434A2 BR112014005434A2 (pt) 2017-04-04
BR112014005434B1 true BR112014005434B1 (pt) 2021-01-05

Family

ID=46846026

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112014005434-7A BR112014005434B1 (pt) 2011-09-08 2012-09-06 Composições farmacêuticas compreendendo inibidor da aromatase 4,4'-[fluoro-(1h-1,2,4triazol-1-il)metilemo]bisbenzonitrila e seu método de preparação
BR112014004879A BR112014004879B1 (pt) 2011-09-08 2012-09-06 uso de inibidor de aromatase para tratamento de hipogonadismo e doenças relacionadas, composição farmacêutica oral, e kit

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112014004879A BR112014004879B1 (pt) 2011-09-08 2012-09-06 uso de inibidor de aromatase para tratamento de hipogonadismo e doenças relacionadas, composição farmacêutica oral, e kit

Country Status (31)

Country Link
US (4) US9370505B2 (enExample)
EP (2) EP2753313B1 (enExample)
JP (2) JP6051467B2 (enExample)
KR (3) KR101872561B1 (enExample)
CN (2) CN103781476B (enExample)
AR (1) AR087790A1 (enExample)
AU (2) AU2012304694B2 (enExample)
BR (2) BR112014005434B1 (enExample)
CA (2) CA2845929C (enExample)
CL (1) CL2014000552A1 (enExample)
CY (2) CY1118461T1 (enExample)
DK (2) DK2753313T3 (enExample)
ES (2) ES2613666T3 (enExample)
HR (2) HRP20170003T1 (enExample)
HU (2) HUE031478T2 (enExample)
IL (1) IL231234A (enExample)
IN (1) IN2014DN01619A (enExample)
LT (2) LT2753313T (enExample)
MX (2) MX360315B (enExample)
PE (1) PE20141584A1 (enExample)
PH (1) PH12014500435A1 (enExample)
PL (2) PL2753312T3 (enExample)
PT (2) PT2753313T (enExample)
RU (2) RU2628808C2 (enExample)
SG (2) SG2014012132A (enExample)
SI (2) SI2753312T1 (enExample)
TN (1) TN2014000059A1 (enExample)
TW (1) TW201316987A (enExample)
UY (1) UY34315A (enExample)
WO (2) WO2013036562A1 (enExample)
ZA (1) ZA201401040B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2753313T (lt) * 2011-09-08 2017-02-10 Mereo Biopharma 2 Limited Farmacinės kompozicijos, apimančios aromatazės inhibitorių
US10324099B2 (en) * 2014-03-26 2019-06-18 The Regents Of The University Of California Ultrasensitive androgen receptor bioassay
TWI707682B (zh) * 2014-07-07 2020-10-21 瑞士商瑞科戴迪股份有限公司 醫藥劑型
GB201614179D0 (en) * 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
EP3592338A1 (en) * 2017-03-08 2020-01-15 ARIAD Pharmaceuticals, Inc. Pharmaceutical formulations comprising 5-chloro-n4
IL322969A (en) 2017-10-12 2025-10-01 Novo Nordisk As Semaglutide in medical therapy
USD894149S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
USD894148S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
JP7121999B2 (ja) * 2019-09-26 2022-08-19 学校法人九州文化学園 男性性腺機能低下症治療剤
US12552754B1 (en) 2025-06-11 2026-02-17 ReproNovo SA Leflutrozole compositions of matter and processes for preparation

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Publication number Priority date Publication date Assignee Title
US4749713A (en) 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
TW210334B (enExample) * 1990-12-12 1993-08-01 Ciba Geigy Ag
DE4435368A1 (de) * 1994-09-22 1996-03-28 Schering Ag Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
US5972921A (en) * 1997-12-12 1999-10-26 Hormos Medical Oy Ltd. Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
WO2002002113A1 (en) * 2000-07-05 2002-01-10 Astrazeneca Ab Pharmaceutical combination of an anti-androgen and letrozole for providing an anit-androgenic effect and aromatase inhibition
SK14252003A3 (sk) 2001-04-17 2004-03-02 Ares Trading S. A. Použitie aromatázového inhibítora, farmaceutický prostriedok s obsahom aromatázového inhibítora a farmaceutické balenie
US7101573B2 (en) 2001-09-28 2006-09-05 Mcneil-Pcc, Inc. Simethicone solid oral dosage form
CA2521305A1 (en) 2002-04-03 2003-10-09 Jencap Research Ltd. Pharmaceutical composition comprising an aromatase inhibitor and an estrogen suitable for hormone replacement therapy for a male
EP1937251A2 (en) * 2005-04-25 2008-07-02 Pfizer Products Inc. Pharmaceutical compositions and methods comprising a combination of a selective estrogen receptor modulator and an aromatase inhibitor
CN102335219A (zh) * 2007-11-21 2012-02-01 客乐谐制药株式会社 芳香酶抑制剂
LT2753313T (lt) * 2011-09-08 2017-02-10 Mereo Biopharma 2 Limited Farmacinės kompozicijos, apimančios aromatazės inhibitorių

Also Published As

Publication number Publication date
JP6051467B2 (ja) 2016-12-27
IN2014DN01619A (enExample) 2015-05-15
HRP20170003T1 (hr) 2017-03-10
AR087790A1 (es) 2014-04-16
SG10201607503WA (en) 2016-10-28
CN103781476A (zh) 2014-05-07
HUE031435T2 (en) 2017-07-28
EP2753313B1 (en) 2016-12-14
IL231234A (en) 2016-12-29
LT2753312T (lt) 2017-01-25
PL2753312T3 (pl) 2017-06-30
BR112014004879A2 (pt) 2017-03-14
CA2845929C (en) 2018-06-19
US20160243084A1 (en) 2016-08-25
HUE031478T2 (hu) 2017-07-28
CA2846884C (en) 2019-04-09
JP2014526465A (ja) 2014-10-06
EP2753312A1 (en) 2014-07-16
SI2753313T1 (sl) 2017-04-26
MX2014002780A (es) 2014-06-05
ZA201401040B (en) 2015-12-23
IL231234A0 (en) 2014-04-30
NZ621476A (en) 2016-02-26
CA2845929A1 (en) 2013-03-14
US20160346257A1 (en) 2016-12-01
RU2628808C2 (ru) 2017-08-22
US20140309267A1 (en) 2014-10-16
CL2014000552A1 (es) 2014-09-12
TW201316987A (zh) 2013-05-01
MX343902B (es) 2016-11-28
KR20140071358A (ko) 2014-06-11
SI2753312T1 (sl) 2017-10-30
CY1118499T1 (el) 2017-07-12
PL2753313T3 (pl) 2017-07-31
CY1118461T1 (el) 2017-07-12
KR20140058619A (ko) 2014-05-14
RU2014113334A (ru) 2015-10-20
CN103796644B (zh) 2017-05-03
US9750724B2 (en) 2017-09-05
JP2014528932A (ja) 2014-10-30
US9370505B2 (en) 2016-06-21
RU2617510C2 (ru) 2017-04-25
WO2013036562A1 (en) 2013-03-14
PH12014500435A1 (en) 2019-03-22
KR20180030254A (ko) 2018-03-21
PT2753313T (pt) 2017-02-02
LT2753313T (lt) 2017-02-10
AU2012304694A1 (en) 2014-03-20
BR112014005434A2 (pt) 2017-04-04
PT2753312T (pt) 2017-02-03
BR112014004879B1 (pt) 2020-01-28
WO2013036563A1 (en) 2013-03-14
JP6280501B2 (ja) 2018-02-14
CA2846884A1 (en) 2013-03-14
ES2613666T3 (es) 2017-05-25
ES2613667T3 (es) 2017-05-25
PE20141584A1 (es) 2014-11-13
MX360315B (es) 2018-10-29
TN2014000059A1 (en) 2015-07-01
AU2012304693B2 (en) 2016-03-31
US20140213622A1 (en) 2014-07-31
EP2753313A1 (en) 2014-07-16
AU2012304693A1 (en) 2014-03-13
UY34315A (es) 2013-04-30
CN103796644A (zh) 2014-05-14
US9295668B2 (en) 2016-03-29
HRP20170002T1 (hr) 2017-02-24
DK2753313T3 (en) 2017-02-13
US10064844B2 (en) 2018-09-04
SG2014012132A (en) 2014-06-27
KR101872561B1 (ko) 2018-06-28
RU2014113575A (ru) 2015-10-20
EP2753312B1 (en) 2016-12-14
MX2014002773A (es) 2014-06-05
AU2012304694B2 (en) 2016-04-07
CN103781476B (zh) 2016-12-07
DK2753312T3 (da) 2017-02-13

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