CN103796644B - 芳香酶抑制剂用于治疗性腺功能减退和相关疾病的用途 - Google Patents

芳香酶抑制剂用于治疗性腺功能减退和相关疾病的用途 Download PDF

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CN103796644B
CN103796644B CN201280043378.9A CN201280043378A CN103796644B CN 103796644 B CN103796644 B CN 103796644B CN 201280043378 A CN201280043378 A CN 201280043378A CN 103796644 B CN103796644 B CN 103796644B
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fluoro
methylene
bisbenzonitrile
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CN103796644A (zh
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A·泰勒
L·B·克里克斯坦
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Novartis AG
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  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280043378.9A 2011-09-08 2012-09-06 芳香酶抑制剂用于治疗性腺功能减退和相关疾病的用途 Active CN103796644B (zh)

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Application Number Priority Date Filing Date Title
US201161532459P 2011-09-08 2011-09-08
US61/532,459 2011-09-08
US201261638588P 2012-04-26 2012-04-26
US61/638,588 2012-04-26
PCT/US2012/053844 WO2013036562A1 (en) 2011-09-08 2012-09-06 Use of an aromatase inhibitor for the treatment of hypogonadism and related diseases

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CN103796644A CN103796644A (zh) 2014-05-14
CN103796644B true CN103796644B (zh) 2017-05-03

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CN201280043614.7A Active CN103781476B (zh) 2011-09-08 2012-09-06 包含芳香酶抑制剂的药物组合物

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SI2753312T1 (sl) * 2011-09-08 2017-10-30 Mereo Biopharma 2 Limited Uporaba inhibitorja aromataze za zdravljenje hipogonadizma in sororodnih bolezni
WO2015148549A1 (en) * 2014-03-26 2015-10-01 The Regents Of The University Of California Ultrasensitive androgen receptor bioassay
PT3166596T (pt) * 2014-07-07 2018-10-19 Novartis Ag Formas farmacêuticas
GB201614179D0 (en) * 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
JP2020510027A (ja) * 2017-03-08 2020-04-02 アリアド ファーマシューティカルズ,インコーポレーテッド 5−クロロ−n4−[2−(ジメチルホスホリル)フェニル]−n2−{2−メトキシ−4−[4−(4−メチルピペラジン−1−イル)ピペリジン−1−イル]フェニル}ピリミジン−2,4−ジアミンを含む医薬製剤
CA3078652A1 (en) 2017-10-12 2019-04-18 Novo Nordisk A/S Semaglutide in medical therapy
USD894149S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
USD894148S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
JP7121999B2 (ja) * 2019-09-26 2022-08-19 学校法人九州文化学園 男性性腺機能低下症治療剤
US12552754B1 (en) 2025-06-11 2026-02-17 ReproNovo SA Leflutrozole compositions of matter and processes for preparation

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US5637605A (en) * 1990-12-12 1997-06-10 Ciba Geigy Corporation α-fluoro-α-1-(1,2,4-triazolyl)-phenylmethyl derivatives useful as aromatase inhibitors
CN1281361A (zh) * 1997-12-12 2001-01-24 霍莫斯医疗有限公司 芳香酶抑制剂治疗泌尿疾病的用途和研究泌尿疾病的方法
WO2002002113A1 (en) * 2000-07-05 2002-01-10 Astrazeneca Ab Pharmaceutical combination of an anti-androgen and letrozole for providing an anit-androgenic effect and aromatase inhibition
WO2003082254A1 (en) * 2002-04-03 2003-10-09 Jencap Research Ltd. Pharmaceutical composition comprising an aromatase inhibitor and an estrogen suitable for hormone replacement therapy for a male
CN1549734A (zh) * 2001-04-17 2004-11-24 ����˹ó�׹ɷ����޹�˾ 增强辅助生殖的芳香酶抑制剂

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SI2753312T1 (sl) * 2011-09-08 2017-10-30 Mereo Biopharma 2 Limited Uporaba inhibitorja aromataze za zdravljenje hipogonadizma in sororodnih bolezni

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US5637605A (en) * 1990-12-12 1997-06-10 Ciba Geigy Corporation α-fluoro-α-1-(1,2,4-triazolyl)-phenylmethyl derivatives useful as aromatase inhibitors
WO1996009057A1 (de) * 1994-09-22 1996-03-28 Schering Aktiengesellschaft Verwendung von aromatasehemmern zur herstellung eines arzneimittels zur behandlung eines relativen androgenmangels beim mann
CN1281361A (zh) * 1997-12-12 2001-01-24 霍莫斯医疗有限公司 芳香酶抑制剂治疗泌尿疾病的用途和研究泌尿疾病的方法
WO2002002113A1 (en) * 2000-07-05 2002-01-10 Astrazeneca Ab Pharmaceutical combination of an anti-androgen and letrozole for providing an anit-androgenic effect and aromatase inhibition
CN1549734A (zh) * 2001-04-17 2004-11-24 ����˹ó�׹ɷ����޹�˾ 增强辅助生殖的芳香酶抑制剂
WO2003082254A1 (en) * 2002-04-03 2003-10-09 Jencap Research Ltd. Pharmaceutical composition comprising an aromatase inhibitor and an estrogen suitable for hormone replacement therapy for a male

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Effect of long-term treatment with aromatase inhibitor on testicular function of adult male bonnet monkeys (M. radiata);Gunapala Shetty et al.;《Steroids》;19980831;第63卷;第414–420页,尤其摘要,第415页右栏第5段,第416页图1 *
Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism;H. de Boer et al.;《Diabetes, Obesity and Metabolism》;20051231;第7卷;第211-215页,尤其摘要,第212页右栏第3-4段 *
STRUCTURE-ACTIVITY RELATIONSHIPS AND BINDING MODEL OF NOVEL AROMATASE INHIBITORS;M. LANG et al.;《J. Steroid Biochem. Molec. Biol》;19931231;第44卷(第4-6期);第421-428页,尤其摘要 *

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MX2014002773A (es) 2014-06-05
CA2846884A1 (en) 2013-03-14
BR112014005434A2 (pt) 2017-04-04
MX343902B (es) 2016-11-28
RU2617510C2 (ru) 2017-04-25
KR20140058619A (ko) 2014-05-14
MX2014002780A (es) 2014-06-05
NZ621476A (en) 2016-02-26
PE20141584A1 (es) 2014-11-13
HUE031435T2 (en) 2017-07-28
BR112014004879B1 (pt) 2020-01-28
US20160243084A1 (en) 2016-08-25
EP2753313B1 (en) 2016-12-14
EP2753313A1 (en) 2014-07-16
CN103781476B (zh) 2016-12-07
UY34315A (es) 2013-04-30
TN2014000059A1 (en) 2015-07-01
SI2753313T1 (sl) 2017-04-26
AU2012304693B2 (en) 2016-03-31
KR20180030254A (ko) 2018-03-21
PL2753312T3 (pl) 2017-06-30

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