KR20140058691A - 1,3-부탄디올을 생산하기 위한 진핵 유기체 및 방법 - Google Patents

1,3-부탄디올을 생산하기 위한 진핵 유기체 및 방법 Download PDF

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KR20140058691A
KR20140058691A KR1020147009246A KR20147009246A KR20140058691A KR 20140058691 A KR20140058691 A KR 20140058691A KR 1020147009246 A KR1020147009246 A KR 1020147009246A KR 20147009246 A KR20147009246 A KR 20147009246A KR 20140058691 A KR20140058691 A KR 20140058691A
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coa
acetyl
bdo
pathway
pathway comprises
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안쏘니 피. 버가드
마크 제이. 버크
로빈 이. 오스터아웃
프리티 파르크야
징이 리
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게노마티카 인코포레이티드
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
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    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/16Dicarboxylic acids and dihydroxy compounds
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/32Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
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    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric

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  • Polymers & Plastics (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020147009246A 2011-09-08 2012-09-07 1,3-부탄디올을 생산하기 위한 진핵 유기체 및 방법 Withdrawn KR20140058691A (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161532492P 2011-09-08 2011-09-08
US61/532,492 2011-09-08
US201161541951P 2011-09-30 2011-09-30
US61/541,951 2011-09-30
US201161558959P 2011-11-11 2011-11-11
US61/558,959 2011-11-11
US201261649039P 2012-05-18 2012-05-18
US61/649,039 2012-05-18
US201261655355P 2012-06-04 2012-06-04
US61/655,355 2012-06-04
PCT/US2012/054152 WO2013036764A1 (en) 2011-09-08 2012-09-07 Eukaryotic organisms and methods for producing 1,3-butanediol

Publications (1)

Publication Number Publication Date
KR20140058691A true KR20140058691A (ko) 2014-05-14

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KR1020147009246A Withdrawn KR20140058691A (ko) 2011-09-08 2012-09-07 1,3-부탄디올을 생산하기 위한 진핵 유기체 및 방법

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Country Link
US (2) US20130066035A1 (enExample)
EP (1) EP2753699A4 (enExample)
KR (1) KR20140058691A (enExample)
CN (1) CN103917651A (enExample)
BR (1) BR112014005352A2 (enExample)
CA (1) CA2848064A1 (enExample)
IN (1) IN2014CN02584A (enExample)
MX (1) MX2014002787A (enExample)
PH (1) PH12014500513A1 (enExample)
SG (1) SG11201400466TA (enExample)
WO (1) WO2013036764A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
JPWO2014045781A1 (ja) * 2012-09-24 2016-08-18 昭和電工株式会社 ブタンジオール類の製造方法
WO2014152665A1 (en) 2013-03-15 2014-09-25 Genomatica, Inc. Process and systems for obtaining 1,4-butanediol from fermentation broths
EP2971021A4 (en) 2013-03-15 2016-12-21 Genomatica Inc MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION
WO2014198831A1 (en) * 2013-06-14 2014-12-18 Technical University Of Denmark Microbial production of 3-hydroxypropionic acid
WO2015057154A2 (en) 2013-10-18 2015-04-23 Biopetrolia Ab ENGINEERING OF ACETYL-CoA METABOLISM IN YEAST
WO2015077752A1 (en) 2013-11-25 2015-05-28 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
EP4296364B1 (en) 2013-12-03 2025-12-03 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
EP3087174B1 (en) 2013-12-27 2020-05-13 Genomatica, Inc. Methods and organisms with increased carbon flux efficiencies
CN120624582A (zh) 2014-09-18 2025-09-12 基因组股份公司 具有提高的能源效率的非天然微生物
MX380426B (es) 2014-12-12 2025-03-12 Versalis Spa Proceso para la produccion de 1,3 butadieno a partir de 1,3 butanodiol.
RU2701863C2 (ru) 2015-02-23 2019-10-02 ВЕРСАЛИС С.п.А. Способ дегидратации кислородсодержащих соединений
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2016196233A1 (en) 2015-05-30 2016-12-08 Genomatica, Inc. Vinylisomerase-dehydratases, alkenol dehydratases, linalool dehydratases and/ crotyl alcohol dehydratases and methods for making and using them
CN104988162B (zh) * 2015-06-08 2020-03-17 天津大学 辅因子再生模块在增强次级代谢产物在微生物中合成的应用
CN104988168A (zh) * 2015-06-08 2015-10-21 天津大学 乙酰辅酶a增强模块在增强7-脱氢胆甾醇在微生物中合成的应用
KR101704212B1 (ko) 2015-06-12 2017-02-08 씨제이제일제당 (주) 젖산을 생산하는 미생물 및 이를 이용한 젖산 제조 방법
US20170009263A1 (en) * 2015-07-08 2017-01-12 Invista North America S.A.R.L. Methods and host cells for enhancing production of 1, 3-butanediol
CA2992794A1 (en) * 2015-07-21 2017-01-26 Radhakrishnan Mahadevan Methods and microorganisms for the production of 1,3-butanediol
EP3359655B1 (en) * 2015-10-06 2019-11-20 DSM IP Assets B.V. Eukaryotic cell with increased production of fermentation product
CN115322261A (zh) 2015-10-30 2022-11-11 基因组股份公司 甲醇脱氢酶融合蛋白
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
AU2018244459B2 (en) 2017-03-31 2024-09-19 Genomatica, Inc. Aldehyde dehydrogenase variants and methods of use
WO2018183640A1 (en) 2017-03-31 2018-10-04 Genomatica, Inc. 3-hydroxybutyryl-coa dehydrogenase variants and methods of use
CN110892073B (zh) * 2017-07-11 2024-03-01 安迪苏法国联合股份有限公司 增强型代谢物生产酵母
MX2020000369A (es) 2017-07-13 2020-08-17 Radici Chimica S P A Metodos biologicos para preparar terpenos.
WO2019014309A1 (en) * 2017-07-13 2019-01-17 Verdezyne (Abc), Llc BIOLOGICAL METHODS FOR MODIFYING A CELL CARBON FLOW
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
CA3103377A1 (en) 2018-06-26 2020-01-02 Genomatica, Inc. Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy
US12227467B2 (en) 2018-09-21 2025-02-18 Versalis S.P.A. Process for bio-1,3-butanediol purification from a fermentation broth
CN113179645A (zh) 2018-09-26 2021-07-27 基因组股份公司 醛脱氢酶变体及其使用方法
WO2020077059A1 (en) * 2018-10-12 2020-04-16 Yield10 Bioscience, Inc. Genetically engineered plants that express a quinone-utilizing malate dehydrogenase
WO2020090017A1 (ja) * 2018-10-30 2020-05-07 Green Earth Institute 株式会社 1,3-プロパンジオールの製造方法
CN110564662B (zh) * 2019-09-30 2022-03-25 南京农业大学 一种整合型高效表达乙醛脱氢酶枯草杆菌的构建方法
CN115873881A (zh) * 2021-09-30 2023-03-31 北京化工大学 一种产1,3-丁二醇的基因工程菌及其应用
CN117701489B (zh) * 2024-02-05 2024-05-10 北京绿色康成生物技术有限公司 一种提高大肠杆菌生产1,3-丁二醇的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU718791B2 (en) * 1995-05-18 2000-04-20 University Of Guelph A method and nucleotide sequence for transforming microorganisms
US8956850B2 (en) * 2008-06-05 2015-02-17 Butamax Advanced Biofuels Llc Enhanced pyruvate to acetolactate conversion in yeast
EP2078092A2 (en) * 2006-09-28 2009-07-15 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
CN102695799A (zh) * 2009-09-27 2012-09-26 Opx生物工艺学公司 用于制备3-羟基丙酸和其它产物的方法
CN109136161A (zh) * 2009-12-10 2019-01-04 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
US8871488B2 (en) * 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases

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SG11201400466TA (en) 2014-04-28
CA2848064A1 (en) 2013-03-14
IN2014CN02584A (enExample) 2015-08-07
EP2753699A4 (en) 2015-08-19
AU2012304428B2 (en) 2016-03-17
CN103917651A (zh) 2014-07-09
US20170247709A1 (en) 2017-08-31
BR112014005352A2 (pt) 2017-03-28
PH12014500513A1 (en) 2014-05-12
AU2012304428A1 (en) 2013-05-02
EP2753699A1 (en) 2014-07-16
WO2013036764A1 (en) 2013-03-14
US20130066035A1 (en) 2013-03-14
MX2014002787A (es) 2014-12-08

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Patent event date: 20140408

Patent event code: PA01051R01D

Comment text: International Patent Application

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PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid