IN2014CN02584A - - Google Patents

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Publication number
IN2014CN02584A
IN2014CN02584A IN2584CHN2014A IN2014CN02584A IN 2014CN02584 A IN2014CN02584 A IN 2014CN02584A IN 2584CHN2014 A IN2584CHN2014 A IN 2584CHN2014A IN 2014CN02584 A IN2014CN02584 A IN 2014CN02584A
Authority
IN
India
Prior art keywords
bdo
produce
naturally occurring
organisms
non naturally
Prior art date
Application number
Inventor
Anthony P Burgard
Mark J Burk
Robin E Osterhout
Priti Pharkya
Jingyi Li
Original Assignee
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Publication of IN2014CN02584A publication Critical patent/IN2014CN02584A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/16—Dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Polymers & Plastics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Provided herein are non naturally occurring eukaryotic organisms that can be engineered to produce and increase the availability of cytosolic acetyl CoA. Also provided herein are non naturally occurring eukaryotic organisms having a 1 3 butanediol (1 3 BDO) pathway and methods of using such organisms to produce 1 3 BDO.
IN2584CHN2014 2011-09-08 2012-09-07 IN2014CN02584A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161532492P 2011-09-08 2011-09-08
US201161541951P 2011-09-30 2011-09-30
US201161558959P 2011-11-11 2011-11-11
US201261649039P 2012-05-18 2012-05-18
US201261655355P 2012-06-04 2012-06-04
PCT/US2012/054152 WO2013036764A1 (en) 2011-09-08 2012-09-07 Eukaryotic organisms and methods for producing 1,3-butanediol

Publications (1)

Publication Number Publication Date
IN2014CN02584A true IN2014CN02584A (en) 2015-08-07

Family

ID=47830417

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2584CHN2014 IN2014CN02584A (en) 2011-09-08 2012-09-07

Country Status (10)

Country Link
US (2) US20130066035A1 (en)
EP (1) EP2753699A4 (en)
KR (1) KR20140058691A (en)
CN (1) CN103917651A (en)
BR (1) BR112014005352A2 (en)
CA (1) CA2848064A1 (en)
IN (1) IN2014CN02584A (en)
MX (1) MX2014002787A (en)
SG (1) SG11201400466TA (en)
WO (1) WO2013036764A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
EP2899270A4 (en) * 2012-09-24 2016-07-20 Showa Denko Kk Method for producing butanediol
CN105209414B (en) 2013-03-15 2018-04-17 基因组股份公司 For obtaining the method and system of 1,4 butanediols from fermentation broth
BR112015020904A2 (en) 2013-03-15 2017-10-10 Genomatica Inc microorganisms and methods for the production of butadiene and related compounds by formate assimilation
EP3008178A1 (en) 2013-06-14 2016-04-20 Technical University of Denmark Microbial production of 3-hydroxypropionic acid
WO2015057154A2 (en) 2013-10-18 2015-04-23 Biopetrolia Ab ENGINEERING OF ACETYL-CoA METABOLISM IN YEAST
US20160376600A1 (en) * 2013-11-25 2016-12-29 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
US10808262B2 (en) 2013-12-03 2020-10-20 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis
ES2800606T3 (en) 2013-12-27 2021-01-04 Genomatica Inc Methods and organisms with higher carbon flux efficiencies
US20170298363A1 (en) 2014-09-18 2017-10-19 Genomatica, Inc Non-natural microbial organisms with improved energetic efficiency
WO2016092063A1 (en) 2014-12-12 2016-06-16 Versalis S.P.A. Process for the production of 1,3 butadiene from 1,3 butanediol
CN107108398B (en) 2015-02-23 2023-10-10 维尔萨利斯股份公司 For oxygen-containing compounds is dehydrated by a method of
BR112017025554B1 (en) 2015-05-30 2024-03-12 Genomatica, Inc. COMPOSITION, AND, METHOD FOR PRODUCING A POLYMER, RESIN OR ARTICLE OF MANUFACTURING
CN104988162B (en) * 2015-06-08 2020-03-17 天津大学 Application of cofactor regeneration module in enhancing synthesis of secondary metabolites in microorganisms
CN104988168A (en) * 2015-06-08 2015-10-21 天津大学 Application of acetyl coenzyme A enhancing module to enhancement of 7-dehydrocholesterol synthesis in microorganisms
KR101704212B1 (en) 2015-06-12 2017-02-08 씨제이제일제당 (주) A microorganism producing lactic acid and method for producing lactic acid using the same
US20170009263A1 (en) * 2015-07-08 2017-01-12 Invista North America S.A.R.L. Methods and host cells for enhancing production of 1, 3-butanediol
CA2992794A1 (en) * 2015-07-21 2017-01-26 Radhakrishnan Mahadevan Methods and microorganisms for the production of 1,3-butanediol
DK3359655T3 (en) * 2015-10-06 2020-02-03 Dsm Ip Assets Bv EUKARYOT CELLE WITH INCREASED PRODUCTION OF FERMENTATION PRODUCT
CN108779153B (en) 2015-10-30 2022-09-06 基因组股份公司 Methanol dehydrogenase fusion proteins
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11299716B2 (en) 2017-03-31 2022-04-12 Genomatica, Inc. Aldehyde dehydrogenase variants and methods of use
WO2018183640A1 (en) 2017-03-31 2018-10-04 Genomatica, Inc. 3-hydroxybutyryl-coa dehydrogenase variants and methods of use
EP3652321B9 (en) * 2017-07-11 2023-10-04 Adisseo France S.A.S. Enhanced metabolite-producing saccharomyces cerevisiae
WO2019014310A1 (en) * 2017-07-13 2019-01-17 Verdezyne (Abc), Llc Biological methods for preparing terpenes
WO2019014309A1 (en) * 2017-07-13 2019-01-17 Verdezyne (Abc), Llc Biological methods for modifying cellular carbon flux
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
EP3814515A2 (en) 2018-06-26 2021-05-05 Genomatica, Inc. Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy
IL281601B2 (en) 2018-09-21 2024-03-01 Versalis Spa Process for bio-1,3-butanediol purification from a fermentation broth
KR20210068489A (en) 2018-09-26 2021-06-09 게노마티카 인코포레이티드 Aldehyde dehydrogenase variants and methods of use thereof
WO2020077059A1 (en) * 2018-10-12 2020-04-16 Yield10 Bioscience, Inc. Genetically engineered plants that express a quinone-utilizing malate dehydrogenase
JP6668577B1 (en) 2018-10-30 2020-03-18 ＧｒｅｅｎＥａｒｔｈＩｎｓｔｉｔｕｔｅ株式会社 Method for producing 1,3-propanediol
CN110564662B (en) * 2019-09-30 2022-03-25 南京农业大学 Construction method of integrated bacillus subtilis for efficiently expressing acetaldehyde dehydrogenase
CN117701489B (en) * 2024-02-05 2024-05-10 北京绿色康成生物技术有限公司 Method for improving production of 1, 3-butanediol by escherichia coli

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0827541B1 (en) * 1995-05-18 2009-11-18 University of Stellenbosch Nucleic acid sequence coding for a malate permease from s. pombe and uses thereof
US8956850B2 (en) * 2008-06-05 2015-02-17 Butamax Advanced Biofuels Llc Enhanced pyruvate to acetolactate conversion in yeast
US8691555B2 (en) * 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
CA2775390C (en) * 2009-09-27 2021-06-29 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
SG181607A1 (en) * 2009-12-10 2012-07-30 Genomatica Inc Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
US8871488B2 (en) * 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases

Also Published As

Publication number Publication date
US20170247709A1 (en) 2017-08-31
KR20140058691A (en) 2014-05-14
EP2753699A4 (en) 2015-08-19
US20130066035A1 (en) 2013-03-14
CN103917651A (en) 2014-07-09
WO2013036764A1 (en) 2013-03-14
EP2753699A1 (en) 2014-07-16
BR112014005352A2 (en) 2017-03-28
CA2848064A1 (en) 2013-03-14
MX2014002787A (en) 2014-12-08
AU2012304428B2 (en) 2016-03-17
SG11201400466TA (en) 2014-04-28
AU2012304428A1 (en) 2013-05-02

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