KR20140014149A - 세린/트레오닌 키나제 저해제로서의 신규 아자인돌릴페닐 설폰아미드 - Google Patents
세린/트레오닌 키나제 저해제로서의 신규 아자인돌릴페닐 설폰아미드 Download PDFInfo
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- KR20140014149A KR20140014149A KR1020137022388A KR20137022388A KR20140014149A KR 20140014149 A KR20140014149 A KR 20140014149A KR 1020137022388 A KR1020137022388 A KR 1020137022388A KR 20137022388 A KR20137022388 A KR 20137022388A KR 20140014149 A KR20140014149 A KR 20140014149A
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- alkyl
- compound
- independently
- cycloalkyl
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
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- Communicable Diseases (AREA)
- Oncology (AREA)
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Applications Claiming Priority (5)
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| EP11181258 | 2011-09-14 | ||
| EP11181258.2 | 2011-09-14 | ||
| PCT/EP2012/051796 WO2012104388A1 (en) | 2011-02-02 | 2012-02-02 | New azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors |
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| EP (1) | EP2670749B1 (https=) |
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| MX (1) | MX2013008868A (https=) |
| PH (1) | PH12013501618A1 (https=) |
| UY (1) | UY33890A (https=) |
| WO (1) | WO2012104388A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180035919A (ko) * | 2015-08-13 | 2018-04-06 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | Irak4억제제 및 이의 용도 |
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| US9290499B2 (en) | 2010-05-19 | 2016-03-22 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180035919A (ko) * | 2015-08-13 | 2018-04-06 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | Irak4억제제 및 이의 용도 |
| US20180244677A1 (en) * | 2015-08-13 | 2018-08-30 | Beijing Hanmi Pharmaceutical Co., Ltd. | Irak4 inhibitor and use thereof |
| US10562902B2 (en) | 2015-08-13 | 2020-02-18 | Beijing Hanmi Pharmaceutical Co., Ltd. | IRAK4 inhibitor and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012104388A1 (en) | 2012-08-09 |
| EP2670749A1 (en) | 2013-12-11 |
| EA201300874A1 (ru) | 2014-02-28 |
| US20130029993A1 (en) | 2013-01-31 |
| BR112013019714A2 (pt) | 2016-10-18 |
| JP2014504622A (ja) | 2014-02-24 |
| PH12013501618A1 (en) | 2013-09-30 |
| CN103476773A (zh) | 2013-12-25 |
| MX2013008868A (es) | 2013-08-14 |
| CA2825279A1 (en) | 2012-08-09 |
| JP5850952B2 (ja) | 2016-02-03 |
| UY33890A (es) | 2012-08-31 |
| CL2013002063A1 (es) | 2013-12-27 |
| EP2670749B1 (en) | 2016-01-27 |
| US8889684B2 (en) | 2014-11-18 |
| IL227399A0 (en) | 2013-09-30 |
| AU2012213390A1 (en) | 2013-08-01 |
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