KR20140008295A - 돌연변이 델타-9 연장효소 및 다중불포화 지방산의 제조에서의 그들의 용도 - Google Patents

돌연변이 델타-9 연장효소 및 다중불포화 지방산의 제조에서의 그들의 용도 Download PDF

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KR20140008295A
KR20140008295A KR1020137007483A KR20137007483A KR20140008295A KR 20140008295 A KR20140008295 A KR 20140008295A KR 1020137007483 A KR1020137007483 A KR 1020137007483A KR 20137007483 A KR20137007483 A KR 20137007483A KR 20140008295 A KR20140008295 A KR 20140008295A
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seq
delta
leu
phe
mutations
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마이클 더블류. 보스틱
홍시안 헤
유겐 리
쿤 주
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이 아이 듀폰 디 네모아 앤드 캄파니
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01016—Acetyl-CoA C-acyltransferase (2.3.1.16)

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  • Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fats And Perfumes (AREA)
KR1020137007483A 2010-08-26 2011-08-26 돌연변이 델타-9 연장효소 및 다중불포화 지방산의 제조에서의 그들의 용도 Withdrawn KR20140008295A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37724810P 2010-08-26 2010-08-26
US61/377,248 2010-08-26
PCT/US2011/049361 WO2012027676A1 (en) 2010-08-26 2011-08-26 Mutant delta-9 elongases and their use in making polyunsaturated fatty acids

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KR20140008295A true KR20140008295A (ko) 2014-01-21

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KR1020137007483A Withdrawn KR20140008295A (ko) 2010-08-26 2011-08-26 돌연변이 델타-9 연장효소 및 다중불포화 지방산의 제조에서의 그들의 용도

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Country Link
US (1) US8980589B2 (https=)
EP (1) EP2609201B1 (https=)
JP (1) JP5963749B2 (https=)
KR (1) KR20140008295A (https=)
CN (1) CN103080316B (https=)
AU (1) AU2011293167B2 (https=)
BR (1) BR112013004356A2 (https=)
CA (1) CA2808000A1 (https=)
CL (1) CL2013000507A1 (https=)
DK (1) DK2609201T3 (https=)
WO (1) WO2012027676A1 (https=)

Cited By (1)

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KR102085555B1 (ko) * 2018-08-27 2020-03-06 대한민국(농촌진흥청장) 아라키돈산 생합성을 위한 신규 델타-5 불포화효소 및 이의 용도

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CA2679659C (en) * 2007-03-01 2016-01-19 Novartis Ag Pim kinase inhibitors and methods of their use
CN102978177B (zh) * 2012-11-09 2015-06-03 浙江工业大学 冬虫夏草合成代谢二十碳五烯酸的△-5-脱氢酶、基因及应用
EP2935591B1 (en) 2012-12-21 2017-07-05 E. I. du Pont de Nemours and Company Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells
CN110358692B (zh) * 2018-04-09 2021-07-27 中国科学院青岛生物能源与过程研究所 生产神经酸的重组酵母菌株及其应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102085555B1 (ko) * 2018-08-27 2020-03-06 대한민국(농촌진흥청장) 아라키돈산 생합성을 위한 신규 델타-5 불포화효소 및 이의 용도

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BR112013004356A2 (pt) 2017-06-27
CN103080316A (zh) 2013-05-01
CA2808000A1 (en) 2012-03-01
JP2013541328A (ja) 2013-11-14
WO2012027676A1 (en) 2012-03-01
EP2609201B1 (en) 2016-03-02
US8980589B2 (en) 2015-03-17
US20120226062A1 (en) 2012-09-06
DK2609201T3 (en) 2016-06-06
AU2011293167A1 (en) 2013-01-24
JP5963749B2 (ja) 2016-08-03
CL2013000507A1 (es) 2014-03-28
EP2609201A1 (en) 2013-07-03
AU2011293167B2 (en) 2016-12-08
CN103080316B (zh) 2016-08-31

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