KR20130116358A - Pi3 키나아제 억제제로서 헤테로사이클릭 화합물 - Google Patents

Pi3 키나아제 억제제로서 헤테로사이클릭 화합물 Download PDF

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Publication number
KR20130116358A
KR20130116358A KR1020137023000A KR20137023000A KR20130116358A KR 20130116358 A KR20130116358 A KR 20130116358A KR 1020137023000 A KR1020137023000 A KR 1020137023000A KR 20137023000 A KR20137023000 A KR 20137023000A KR 20130116358 A KR20130116358 A KR 20130116358A
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South Korea
Prior art keywords
fluoro
ethyl
purin
benzoimidazol
amine
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KR1020137023000A
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Korean (ko)
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로버트 힐드
스티븐 프라이스
브라이언 사피나
파스칼 피에르 알렉산더 사비
에일린 엠 세워드
다니엘 피 수더린
보단 와즈코이즈
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에프. 호프만-라 로슈 아게
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Publication of KR20130116358A publication Critical patent/KR20130116358A/ko

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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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KR1020137023000A 2011-02-09 2012-02-08 Pi3 키나아제 억제제로서 헤테로사이클릭 화합물 KR20130116358A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161441014P 2011-02-09 2011-02-09
US61/441,014 2011-02-09
PCT/EP2012/052090 WO2012107465A1 (en) 2011-02-09 2012-02-08 Heterocyclic compounds as pi3 kinase inhibitors

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KR20130116358A true KR20130116358A (ko) 2013-10-23

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KR1020137023000A KR20130116358A (ko) 2011-02-09 2012-02-08 Pi3 키나아제 억제제로서 헤테로사이클릭 화합물

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Country Link
US (1) US8653089B2 (ru)
EP (1) EP2673269A1 (ru)
JP (1) JP5766820B2 (ru)
KR (1) KR20130116358A (ru)
CN (1) CN103476767B (ru)
BR (1) BR112013020329A2 (ru)
CA (1) CA2825028A1 (ru)
MX (1) MX2013008822A (ru)
RU (1) RU2013138835A (ru)
WO (1) WO2012107465A1 (ru)

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CN103476767A (zh) 2013-12-25
CA2825028A1 (en) 2012-08-16
MX2013008822A (es) 2013-10-07
CN103476767B (zh) 2015-06-10
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