KR20130061148A - 고혈압 치료용 약학 조성물 및 방법 - Google Patents
고혈압 치료용 약학 조성물 및 방법 Download PDFInfo
- Publication number
- KR20130061148A KR20130061148A KR1020127031507A KR20127031507A KR20130061148A KR 20130061148 A KR20130061148 A KR 20130061148A KR 1020127031507 A KR1020127031507 A KR 1020127031507A KR 20127031507 A KR20127031507 A KR 20127031507A KR 20130061148 A KR20130061148 A KR 20130061148A
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- KR
- South Korea
- Prior art keywords
- dextromethorphan
- effective amount
- pharmaceutical composition
- amlodipine
- calcium channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960000528 amlodipine Drugs 0.000 claims abstract description 72
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- 229940127291 Calcium channel antagonist Drugs 0.000 claims abstract description 53
- 239000000480 calcium channel blocker Substances 0.000 claims abstract description 53
- 238000011282 treatment Methods 0.000 claims abstract description 37
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims abstract 22
- 208000024891 symptom Diseases 0.000 claims description 33
- -1 eponidipine Chemical compound 0.000 claims description 25
- 239000003937 drug carrier Substances 0.000 claims description 16
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- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 8
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- JQSAYKKFZOSZGJ-UHFFFAOYSA-N 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine Chemical compound COC1=C(OC)C(OC)=CC=C1CN1CCN(C(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CC1 JQSAYKKFZOSZGJ-UHFFFAOYSA-N 0.000 claims description 4
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 4
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- IFFPICMESYHZPQ-UHFFFAOYSA-N Prenylamine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCNC(C)CC1=CC=CC=C1 IFFPICMESYHZPQ-UHFFFAOYSA-N 0.000 claims description 4
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- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims description 4
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| US9102635B2 (en) * | 2013-02-14 | 2015-08-11 | Novartis Ag | Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy |
| US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| WO2017028814A1 (en) * | 2015-08-20 | 2017-02-23 | Tsh Biopharm Corporation Ltd. | Pharmaceutical composition comprising amlodipine and dextromethorphan |
| EP4620525A3 (en) | 2016-12-14 | 2025-12-03 | Respira Therapeutics, Inc. | Methods and compositions for treatment of pulmonary hypertension and other lung disorders |
| KR20240096848A (ko) | 2017-01-25 | 2024-06-26 | 더 조지 인스티튜트 포 글로벌 헬스 | 고혈압의 치료를 위한 조성물 |
| US12521380B2 (en) | 2017-01-25 | 2026-01-13 | The George Institute for Global Health | Compositions for the treatment of hypertension |
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| US2676177A (en) | 1949-11-09 | 1954-04-20 | Hoffmann La Roche | Process for the preparation of optically active 3-methoxy-n-methyl morphinans and salts thereof |
| GB8710493D0 (en) | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Dihydropyridines |
| JPH06500554A (ja) * | 1990-08-23 | 1994-01-20 | ザ・チルドレンズ・メディカル・センター・コーポレイション | エイズ性痴呆、脊髄障害、末梢神経障害、および視覚喪失の治療 |
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| US6057344A (en) | 1991-11-26 | 2000-05-02 | Sepracor, Inc. | Methods for treating hypertension, and angina using optically pure (-) amlodipine |
| US5560913A (en) | 1995-01-27 | 1996-10-01 | The Procter & Gamble Company | Pharmaceutical compositions |
| EP1505068A4 (en) * | 2002-04-23 | 2008-03-19 | Shionogi & Co | PYRAZOLO (1,5-a) PYRIMIDINE DERIVATIVE AND INHIBITOR OF NAD (P) H OXIDASE CONTAINING SAID DERIVATIVE |
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| US8569374B2 (en) | 2004-09-16 | 2013-10-29 | The Trustees Of The University Of Pennsylvania | NADPH oxidase inhibition pharmacotherapies for obstructive sleep apnea syndrome and its associated morbidities |
| US20060188450A1 (en) * | 2005-02-24 | 2006-08-24 | Tim Clarot | System and method for suppressing a cough |
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| US7820689B2 (en) * | 2006-08-10 | 2010-10-26 | Hua-Lin Wu | Methods and compositions for preventing or treating cardiovascular disease |
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2011
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- 2011-04-29 MY MYPI2012004815A patent/MY161853A/en unknown
- 2011-04-29 EP EP11777155.0A patent/EP2566478A4/en not_active Withdrawn
- 2011-04-29 JP JP2013508361A patent/JP5847162B2/ja not_active Expired - Fee Related
- 2011-04-29 BR BR112012028153A patent/BR112012028153A2/pt not_active IP Right Cessation
- 2011-04-29 TW TW100115056A patent/TWI583383B/zh not_active IP Right Cessation
- 2011-04-29 US US13/695,628 patent/US20130053411A1/en not_active Abandoned
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- 2011-04-29 KR KR1020127031507A patent/KR20130061148A/ko not_active Ceased
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- 2011-04-29 RU RU2012151051/15A patent/RU2571284C2/ru not_active IP Right Cessation
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| TW201206437A (en) | 2012-02-16 |
| US20130053411A1 (en) | 2013-02-28 |
| CN102869360B (zh) | 2015-03-25 |
| EP2566478A1 (en) | 2013-03-13 |
| JP5847162B2 (ja) | 2016-01-20 |
| US9744165B2 (en) | 2017-08-29 |
| MY161853A (en) | 2017-05-15 |
| AU2011250485B2 (en) | 2016-07-07 |
| AU2011250485A1 (en) | 2012-12-06 |
| EP2566478A4 (en) | 2014-04-30 |
| BR112012028153A2 (pt) | 2018-08-07 |
| CN102869360A (zh) | 2013-01-09 |
| WO2011137734A1 (en) | 2011-11-10 |
| TWI583383B (zh) | 2017-05-21 |
| RU2012151051A (ru) | 2014-06-10 |
| US20160235741A1 (en) | 2016-08-18 |
| JP2013525460A (ja) | 2013-06-20 |
| RU2571284C2 (ru) | 2015-12-20 |
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