JP5847162B2 - 高血圧治療用医薬組成物及び方法 - Google Patents
高血圧治療用医薬組成物及び方法 Download PDFInfo
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- JP5847162B2 JP5847162B2 JP2013508361A JP2013508361A JP5847162B2 JP 5847162 B2 JP5847162 B2 JP 5847162B2 JP 2013508361 A JP2013508361 A JP 2013508361A JP 2013508361 A JP2013508361 A JP 2013508361A JP 5847162 B2 JP5847162 B2 JP 5847162B2
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- amlodipine
- dextromethorphan
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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| US61/330,540 | 2010-05-03 | ||
| PCT/CN2011/073560 WO2011137734A1 (en) | 2010-05-03 | 2011-04-29 | Pharmaceutical composition and method for treating hypertension |
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| JP2013525460A JP2013525460A (ja) | 2013-06-20 |
| JP2013525460A5 JP2013525460A5 (https=) | 2014-06-19 |
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| US9102635B2 (en) * | 2013-02-14 | 2015-08-11 | Novartis Ag | Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy |
| US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| WO2017028814A1 (en) * | 2015-08-20 | 2017-02-23 | Tsh Biopharm Corporation Ltd. | Pharmaceutical composition comprising amlodipine and dextromethorphan |
| EP4620525A3 (en) | 2016-12-14 | 2025-12-03 | Respira Therapeutics, Inc. | Methods and compositions for treatment of pulmonary hypertension and other lung disorders |
| KR20240096848A (ko) | 2017-01-25 | 2024-06-26 | 더 조지 인스티튜트 포 글로벌 헬스 | 고혈압의 치료를 위한 조성물 |
| US12521380B2 (en) | 2017-01-25 | 2026-01-13 | The George Institute for Global Health | Compositions for the treatment of hypertension |
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| US2676177A (en) | 1949-11-09 | 1954-04-20 | Hoffmann La Roche | Process for the preparation of optically active 3-methoxy-n-methyl morphinans and salts thereof |
| GB8710493D0 (en) | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Dihydropyridines |
| JPH06500554A (ja) * | 1990-08-23 | 1994-01-20 | ザ・チルドレンズ・メディカル・センター・コーポレイション | エイズ性痴呆、脊髄障害、末梢神経障害、および視覚喪失の治療 |
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| US5350756A (en) * | 1991-06-17 | 1994-09-27 | Smith Richard A | Use of a cytochrome oxidase inhibitor to increase the cough-suppressing activity of dextromorphan |
| US6057344A (en) | 1991-11-26 | 2000-05-02 | Sepracor, Inc. | Methods for treating hypertension, and angina using optically pure (-) amlodipine |
| US5560913A (en) | 1995-01-27 | 1996-10-01 | The Procter & Gamble Company | Pharmaceutical compositions |
| EP1505068A4 (en) * | 2002-04-23 | 2008-03-19 | Shionogi & Co | PYRAZOLO (1,5-a) PYRIMIDINE DERIVATIVE AND INHIBITOR OF NAD (P) H OXIDASE CONTAINING SAID DERIVATIVE |
| US7923454B2 (en) * | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP2987788A1 (en) * | 2002-05-17 | 2016-02-24 | Taiwanj Pharmaceuticals Co., Ltd. | Opioid and opioid-like compounds and uses thereof |
| TWI326214B (en) * | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
| KR100476636B1 (ko) | 2002-09-11 | 2005-03-17 | 한림제약(주) | 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법 |
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| US8569374B2 (en) | 2004-09-16 | 2013-10-29 | The Trustees Of The University Of Pennsylvania | NADPH oxidase inhibition pharmacotherapies for obstructive sleep apnea syndrome and its associated morbidities |
| US20060188450A1 (en) * | 2005-02-24 | 2006-08-24 | Tim Clarot | System and method for suppressing a cough |
| US7939567B2 (en) * | 2006-02-24 | 2011-05-10 | Blue Blood Biotech Corp. | Dextromethorphan-based method for treating acne |
| US7820689B2 (en) * | 2006-08-10 | 2010-10-26 | Hua-Lin Wu | Methods and compositions for preventing or treating cardiovascular disease |
| US8569364B2 (en) * | 2007-11-28 | 2013-10-29 | Sequoia Pharmaceuticals, Inc. | 5-substituted benzofurans as inhibitors of cytochrome P450 2D6 |
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| BR112012028153A2 (pt) | 2018-08-07 |
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| WO2011137734A1 (en) | 2011-11-10 |
| TWI583383B (zh) | 2017-05-21 |
| RU2012151051A (ru) | 2014-06-10 |
| US20160235741A1 (en) | 2016-08-18 |
| JP2013525460A (ja) | 2013-06-20 |
| RU2571284C2 (ru) | 2015-12-20 |
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