KR20120123077A - 다루나비르 다형체 및 그의 제조 방법 - Google Patents

다루나비르 다형체 및 그의 제조 방법 Download PDF

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Publication number
KR20120123077A
KR20120123077A KR1020127020434A KR20127020434A KR20120123077A KR 20120123077 A KR20120123077 A KR 20120123077A KR 1020127020434 A KR1020127020434 A KR 1020127020434A KR 20127020434 A KR20127020434 A KR 20127020434A KR 20120123077 A KR20120123077 A KR 20120123077A
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KR
South Korea
Prior art keywords
darunavir
crystalline
hydrate
water
darunavir hydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020127020434A
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English (en)
Korean (ko)
Inventor
만진더 싱 풀
다르마라즈 라마찬드라 라오
라젠드라 나라얀라오 칸칸
Original Assignee
씨아이피엘에이 엘티디.
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Publication date
Application filed by 씨아이피엘에이 엘티디. filed Critical 씨아이피엘에이 엘티디.
Publication of KR20120123077A publication Critical patent/KR20120123077A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020127020434A 2010-01-05 2010-10-06 다루나비르 다형체 및 그의 제조 방법 Ceased KR20120123077A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN33MU2010 2010-01-05
IN33/MUM/2010 2010-01-05
PCT/GB2010/001874 WO2011083287A2 (en) 2010-01-05 2010-10-06 Darunavir polymorph and process for preparation thereof

Publications (1)

Publication Number Publication Date
KR20120123077A true KR20120123077A (ko) 2012-11-07

Family

ID=43125640

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127020434A Ceased KR20120123077A (ko) 2010-01-05 2010-10-06 다루나비르 다형체 및 그의 제조 방법

Country Status (9)

Country Link
US (2) US20130029945A1 (enExample)
EP (1) EP2521728B1 (enExample)
JP (2) JP2013516397A (enExample)
KR (1) KR20120123077A (enExample)
AU (1) AU2010340799B2 (enExample)
CA (1) CA2785998A1 (enExample)
NZ (1) NZ600994A (enExample)
WO (1) WO2011083287A2 (enExample)
ZA (1) ZA201204365B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700645B2 (en) 2002-05-16 2010-04-20 Tibotec Pharmaceuticals Ltd. Pseudopolymorphic forms of a HIV protease inhibitor
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
PL2528923T3 (pl) 2010-01-28 2015-01-30 Mapi Pharma Ltd Sposób wytwarzania darunawiru i pochodnych darunawiru
US9216990B2 (en) * 2011-12-05 2015-12-22 Mylan Labs Limited Crystalline Darunavir
CN103509031B (zh) * 2012-06-20 2016-04-27 上海迪赛诺药业有限公司 制备达芦那韦无定形物的方法
EP3795572B1 (en) 2012-07-24 2023-11-15 Laurus Labs Limited Darunavir propionate solvate
WO2016092525A1 (en) 2014-12-12 2016-06-16 Lupin Limited Darunavir n-propanol solvate and process for preparation thereof
CN106854212A (zh) * 2015-12-08 2017-06-16 浙江九洲药业股份有限公司 一种达芦那韦无定型的制备方法
CN106242307A (zh) * 2016-08-11 2016-12-21 京东方科技集团股份有限公司 用于强化制品的边缘的方法、玻璃及显示装置
EP3532478B1 (en) * 2016-10-27 2021-05-26 Gilead Sciences, Inc. Crystalline form of darunavir free base
CN108727401A (zh) * 2017-04-20 2018-11-02 盐城迪赛诺制药有限公司 达鲁那韦新晶型及其制备方法和应用
CN108794498A (zh) * 2017-05-03 2018-11-13 江苏瑞科医药科技有限公司 一种达芦那韦无定型的制备方法
CN109053753A (zh) * 2018-08-05 2018-12-21 浙江大学 一种制备达卢那韦二水合物晶型的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2127938T3 (es) 1993-08-24 1999-05-01 Searle & Co Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.
PT2336134T (pt) 1998-06-23 2016-10-19 The Board Of Trustees Of The Univ Of Illionis Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
US7700645B2 (en) * 2002-05-16 2010-04-20 Tibotec Pharmaceuticals Ltd. Pseudopolymorphic forms of a HIV protease inhibitor
KR101192859B1 (ko) 2003-12-23 2012-10-19 얀센 알 앤드 디 아일랜드 （3ｒ,3ａｓ,6ａｒ）-헥사하이드로푸로〔2,3-ｂ〕푸란-3-일（1ｓ,2ｒ）-3-〔〔（4-아미노페닐）설포닐〕（이소부틸）아미노〕-1-벤질-2-하이드록시프로필카바메이트의 제조방법
CA2776807C (en) * 2009-09-17 2018-10-16 Mylan Laboratories Limited An improved process for the preparation of darunavir
WO2011073993A1 (en) * 2009-12-16 2011-06-23 Hetero Research Foundation Polymorphs of darunavir

Also Published As

Publication number Publication date
WO2011083287A2 (en) 2011-07-14
JP2013516397A (ja) 2013-05-13
CA2785998A1 (en) 2011-07-14
JP2016028085A (ja) 2016-02-25
ZA201204365B (en) 2013-12-23
AU2010340799A1 (en) 2012-07-05
WO2011083287A3 (en) 2011-09-15
EP2521728B1 (en) 2016-09-07
NZ600994A (en) 2014-04-30
US20130029945A1 (en) 2013-01-31
US20150141383A1 (en) 2015-05-21
EP2521728A2 (en) 2012-11-14
AU2010340799B2 (en) 2015-06-11

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