KR20120114235A - 알파-1 프로테이나제 억제제에 대한 조성물, 방법 및 키트 - Google Patents

알파-1 프로테이나제 억제제에 대한 조성물, 방법 및 키트 Download PDF

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Publication number
KR20120114235A
KR20120114235A KR1020127013706A KR20127013706A KR20120114235A KR 20120114235 A KR20120114235 A KR 20120114235A KR 1020127013706 A KR1020127013706 A KR 1020127013706A KR 20127013706 A KR20127013706 A KR 20127013706A KR 20120114235 A KR20120114235 A KR 20120114235A
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South Korea
Prior art keywords
composition
api
amino acid
alanine
formulation
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Ceased
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KR1020127013706A
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English (en)
Korean (ko)
Inventor
지안신 궈
앤터니 클로스
브렛 콜드렌
데보라 바네트
마크 매닝
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그리폴스 테라퓨틱스 인코포레이티드
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Application filed by 그리폴스 테라퓨틱스 인코포레이티드 filed Critical 그리폴스 테라퓨틱스 인코포레이티드
Publication of KR20120114235A publication Critical patent/KR20120114235A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020127013706A 2009-11-03 2010-11-02 알파-1 프로테이나제 억제제에 대한 조성물, 방법 및 키트 Ceased KR20120114235A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25771109P 2009-11-03 2009-11-03
US61/257,711 2009-11-03

Publications (1)

Publication Number Publication Date
KR20120114235A true KR20120114235A (ko) 2012-10-16

Family

ID=43970713

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127013706A Ceased KR20120114235A (ko) 2009-11-03 2010-11-02 알파-1 프로테이나제 억제제에 대한 조성물, 방법 및 키트

Country Status (19)

Country Link
US (2) US20130131192A1 (enExample)
EP (1) EP2496246B1 (enExample)
JP (2) JP2013510158A (enExample)
KR (1) KR20120114235A (enExample)
CN (1) CN102655876B (enExample)
AU (1) AU2010315325B2 (enExample)
BR (1) BR112012010392B8 (enExample)
CA (1) CA2779369C (enExample)
CL (1) CL2012001159A1 (enExample)
ES (1) ES2679819T3 (enExample)
HU (1) HUE039240T2 (enExample)
IL (1) IL219485A (enExample)
MX (1) MX2012005132A (enExample)
NZ (1) NZ599783A (enExample)
PL (1) PL2496246T3 (enExample)
PT (1) PT2496246T (enExample)
RU (1) RU2555332C2 (enExample)
TR (1) TR201809898T4 (enExample)
WO (1) WO2011056793A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014007127A2 (pt) * 2011-12-30 2017-04-04 Grifols Sa métodos para retardar o início ou diminuir a progressão de um ou mais sintomas, para retardar o início ou a progressão de um ou mais sintomas, para identificar um indivíduo em necessidade de terapia de manutenção de a1pi, e para identificar indivíduos com risco elevado para exacerbações pulmonares, uso de a1pi, aparelho e meio para a administração aerossolizada de a1pi para a inalação, e, kit
WO2018116300A1 (en) * 2016-12-22 2018-06-28 Kamada Ltd. Dry powder formulations of alpha-1 antitrypsin
WO2018132874A1 (en) * 2017-01-19 2018-07-26 Csl Limited Method of preventing an immune response with alpha- 1 anti-trypsin
IL267923B2 (en) 2018-08-02 2023-06-01 Grifols Worldwide Operations Ltd The composition containing the most concentrated alpha-1 type protein inhibitor and a method for obtaining it
KR102824423B1 (ko) * 2019-03-04 2025-06-25 티에이이 라이프 사이언시스 엘엘씨 붕소 중성자 포획 요법에서 사용하기 위한 보릴화된 아미노산 조성물 및 그의 방법
WO2021170531A1 (en) 2020-02-25 2021-09-02 Grifols Worldwide Operations Limited Method for obtaining alpha-1 proteinase inhibitor

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Also Published As

Publication number Publication date
MX2012005132A (es) 2012-07-25
JP2015221835A (ja) 2015-12-10
BR112012010392A2 (pt) 2016-07-12
IL219485A0 (en) 2012-06-28
IL219485A (en) 2017-06-29
ES2679819T3 (es) 2018-08-31
RU2012122793A (ru) 2013-12-10
TR201809898T4 (tr) 2018-07-23
EP2496246A4 (en) 2013-03-27
ES2679819T8 (es) 2019-01-22
CN102655876B (zh) 2015-07-15
PL2496246T3 (pl) 2018-09-28
CN102655876A (zh) 2012-09-05
EP2496246B1 (en) 2018-06-27
CL2012001159A1 (es) 2012-09-14
US9616126B2 (en) 2017-04-11
AU2010315325B2 (en) 2014-11-27
WO2011056793A3 (en) 2011-09-29
BR112012010392B1 (pt) 2021-01-05
WO2011056793A2 (en) 2011-05-12
HUE039240T2 (hu) 2018-12-28
RU2555332C2 (ru) 2015-07-10
US20160106843A1 (en) 2016-04-21
US20130131192A1 (en) 2013-05-23
PT2496246T (pt) 2018-07-31
NZ599783A (en) 2013-10-25
AU2010315325A1 (en) 2012-06-07
CA2779369C (en) 2018-06-19
JP6030201B2 (ja) 2016-11-24
CA2779369A1 (en) 2011-05-12
JP2013510158A (ja) 2013-03-21
BR112012010392B8 (pt) 2021-05-25
EP2496246A2 (en) 2012-09-12

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