JP2013510158A - α‐１プロテイナーゼインヒビターのための組成物、方法およびキット - Google Patents

α‐１プロテイナーゼインヒビターのための組成物、方法およびキット Download PDF

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Publication number
JP2013510158A
JP2013510158A JP2012537945A JP2012537945A JP2013510158A JP 2013510158 A JP2013510158 A JP 2013510158A JP 2012537945 A JP2012537945 A JP 2012537945A JP 2012537945 A JP2012537945 A JP 2012537945A JP 2013510158 A JP2013510158 A JP 2013510158A
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api
composition
amino acid
alanine
formulation
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JP2013510158A5 (enExample
Inventor
グオ ジャンシン
クロス アンソニー
コールドレン ブレット
バーネット デボラ
マニング マーク
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Grifols Therapeutics LLC
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Grifols Therapeutics LLC
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Publication of JP2013510158A publication Critical patent/JP2013510158A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012537945A 2009-11-03 2010-11-02 α‐１プロテイナーゼインヒビターのための組成物、方法およびキット Withdrawn JP2013510158A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25771109P 2009-11-03 2009-11-03
US61/257,711 2009-11-03
PCT/US2010/055135 WO2011056793A2 (en) 2009-11-03 2010-11-02 Composition, method, and kit for alpha-1 proteinase inhibitor

Related Child Applications (1)

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JP2015175001A Division JP6030201B2 (ja) 2009-11-03 2015-09-04 α‐１プロテイナーゼインヒビターのための組成物、方法およびキット

Publications (2)

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JP2013510158A true JP2013510158A (ja) 2013-03-21
JP2013510158A5 JP2013510158A5 (enExample) 2013-09-26

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JP2012537945A Withdrawn JP2013510158A (ja) 2009-11-03 2010-11-02 α‐１プロテイナーゼインヒビターのための組成物、方法およびキット
JP2015175001A Active JP6030201B2 (ja) 2009-11-03 2015-09-04 α‐１プロテイナーゼインヒビターのための組成物、方法およびキット

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US (2) US20130131192A1 (enExample)
EP (1) EP2496246B1 (enExample)
JP (2) JP2013510158A (enExample)
KR (1) KR20120114235A (enExample)
CN (1) CN102655876B (enExample)
AU (1) AU2010315325B2 (enExample)
BR (1) BR112012010392B8 (enExample)
CA (1) CA2779369C (enExample)
CL (1) CL2012001159A1 (enExample)
ES (1) ES2679819T3 (enExample)
HU (1) HUE039240T2 (enExample)
IL (1) IL219485A (enExample)
MX (1) MX2012005132A (enExample)
NZ (1) NZ599783A (enExample)
PL (1) PL2496246T3 (enExample)
PT (1) PT2496246T (enExample)
RU (1) RU2555332C2 (enExample)
TR (1) TR201809898T4 (enExample)
WO (1) WO2011056793A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012337241B2 (en) * 2011-12-30 2016-10-13 Grifols, S.A. Alpha1-proteinase inhibitor for delaying the onset or progression of pulmonary exacerbations
US20210085764A1 (en) * 2016-12-22 2021-03-25 Kamada Ltd. Dry powder formulations of alpha-1 antitrypsin
WO2018132874A1 (en) * 2017-01-19 2018-07-26 Csl Limited Method of preventing an immune response with alpha- 1 anti-trypsin
IL267923B2 (en) 2018-08-02 2023-06-01 Grifols Worldwide Operations Ltd The composition containing the most concentrated alpha-1 type protein inhibitor and a method for obtaining it
JP7545987B2 (ja) 2019-03-04 2024-09-05 ティーエーイー ライフ サイエンシーズ ホウ素中性子捕捉療法において使用するためのボリル化されたアミノ酸組成物およびその方法
BR112022016234A2 (pt) 2020-02-25 2022-10-11 Grifols Worldwide Operations Ltd Método para obtenção de inibidor de proteinase alfa-1

Citations (4)

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JPS51118819A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable antitrypsin
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
JP2002275090A (ja) * 2000-05-08 2002-09-25 Aventis Behring Gmbh 安定化蛋白質調製物およびその調製方法
JP2007511539A (ja) * 2003-11-14 2007-05-10 バクスター・インターナショナル・インコーポレイテッド α１−抗トリプシン組成物およびこのような組成物を用いた処置方法

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JPS51118819A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable antitrypsin
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
JP2002275090A (ja) * 2000-05-08 2002-09-25 Aventis Behring Gmbh 安定化蛋白質調製物およびその調製方法
JP2007511539A (ja) * 2003-11-14 2007-05-10 バクスター・インターナショナル・インコーポレイテッド α１−抗トリプシン組成物およびこのような組成物を用いた処置方法

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Publication number Publication date
RU2555332C2 (ru) 2015-07-10
PL2496246T3 (pl) 2018-09-28
JP6030201B2 (ja) 2016-11-24
WO2011056793A3 (en) 2011-09-29
AU2010315325B2 (en) 2014-11-27
US20160106843A1 (en) 2016-04-21
EP2496246B1 (en) 2018-06-27
KR20120114235A (ko) 2012-10-16
BR112012010392B1 (pt) 2021-01-05
NZ599783A (en) 2013-10-25
CA2779369C (en) 2018-06-19
US20130131192A1 (en) 2013-05-23
AU2010315325A1 (en) 2012-06-07
ES2679819T3 (es) 2018-08-31
ES2679819T8 (es) 2019-01-22
US9616126B2 (en) 2017-04-11
PT2496246T (pt) 2018-07-31
IL219485A (en) 2017-06-29
RU2012122793A (ru) 2013-12-10
TR201809898T4 (tr) 2018-07-23
JP2015221835A (ja) 2015-12-10
CL2012001159A1 (es) 2012-09-14
CN102655876A (zh) 2012-09-05
HUE039240T2 (hu) 2018-12-28
MX2012005132A (es) 2012-07-25
BR112012010392A2 (pt) 2016-07-12
CA2779369A1 (en) 2011-05-12
EP2496246A2 (en) 2012-09-12
WO2011056793A2 (en) 2011-05-12
BR112012010392B8 (pt) 2021-05-25
IL219485A0 (en) 2012-06-28
EP2496246A4 (en) 2013-03-27
CN102655876B (zh) 2015-07-15

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