BR112022016234A2 - Método para obtenção de inibidor de proteinase alfa-1 - Google Patents

Método para obtenção de inibidor de proteinase alfa-1

Info

Publication number
BR112022016234A2
BR112022016234A2 BR112022016234A BR112022016234A BR112022016234A2 BR 112022016234 A2 BR112022016234 A2 BR 112022016234A2 BR 112022016234 A BR112022016234 A BR 112022016234A BR 112022016234 A BR112022016234 A BR 112022016234A BR 112022016234 A2 BR112022016234 A2 BR 112022016234A2
Authority
BR
Brazil
Prior art keywords
obtaining
a1pi
alpha
inhibitor
solution
Prior art date
Application number
BR112022016234A
Other languages
English (en)
Inventor
Rebbeor James
A Yuziuk Jeffrey
Grady George
McBRIDE DENNIS
Original Assignee
Grifols Worldwide Operations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grifols Worldwide Operations Ltd filed Critical Grifols Worldwide Operations Ltd
Publication of BR112022016234A2 publication Critical patent/BR112022016234A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

MÉTODO PARA OBTENÇÃO DE INIBIDOR DE PROTEINASE ALFA-1. A presente invenção refere-se a métodos para obter um Inibidor de Proteinase Alfa-1 altamente concentrado (A1PI) compreendendo uma etapa de preparação de uma solução de A1PI concentrando uma solução inicial de A1PI por filtração de fluxo tangencial (TFF) contra água, em que a concentração final de A1PI na solução concentrada é de pelo menos 110 mg/ml.
BR112022016234A 2020-02-25 2021-02-22 Método para obtenção de inibidor de proteinase alfa-1 BR112022016234A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062981410P 2020-02-25 2020-02-25
PCT/EP2021/054302 WO2021170531A1 (en) 2020-02-25 2021-02-22 Method for obtaining alpha-1 proteinase inhibitor

Publications (1)

Publication Number Publication Date
BR112022016234A2 true BR112022016234A2 (pt) 2022-10-11

Family

ID=74758764

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022016234A BR112022016234A2 (pt) 2020-02-25 2021-02-22 Método para obtenção de inibidor de proteinase alfa-1

Country Status (13)

Country Link
EP (1) EP4110808A1 (pt)
JP (1) JP2023515431A (pt)
KR (1) KR20220145352A (pt)
CN (1) CN115135667A (pt)
AR (1) AR121391A1 (pt)
AU (1) AU2021225310A1 (pt)
BR (1) BR112022016234A2 (pt)
CA (1) CA3168165A1 (pt)
IL (1) IL295661A (pt)
MX (1) MX2022010087A (pt)
TW (1) TW202139973A (pt)
UY (1) UY39091A (pt)
WO (1) WO2021170531A1 (pt)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6462180B1 (en) 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
US20110237781A1 (en) 2008-07-18 2011-09-29 Talecris Biotherapeutics, Inc. Method of preparing alpha-1 proteinase inhibitor
RU2555332C2 (ru) 2009-11-03 2015-07-10 Грифольс Терапьютикс Инк. Композиция, способ и набор для альфа-1 ингибитора протеазы
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
US10550148B2 (en) * 2014-06-16 2020-02-04 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
US20210032314A1 (en) * 2018-03-12 2021-02-04 Protease Pharmaceuticals Inc. Methods and compositions for alpha-1 antitrypsin related disease disorders
IL267923B2 (en) * 2018-08-02 2023-06-01 Grifols Worldwide Operations Ltd The composition containing the most concentrated alpha-1 type protein inhibitor and a method for obtaining it

Also Published As

Publication number Publication date
UY39091A (es) 2021-08-31
CA3168165A1 (en) 2021-09-02
MX2022010087A (es) 2022-09-02
AU2021225310A1 (en) 2022-10-06
IL295661A (en) 2022-10-01
KR20220145352A (ko) 2022-10-28
CN115135667A (zh) 2022-09-30
EP4110808A1 (en) 2023-01-04
AR121391A1 (es) 2022-06-01
JP2023515431A (ja) 2023-04-13
WO2021170531A1 (en) 2021-09-02
TW202139973A (zh) 2021-11-01

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