KR20120093867A - 비시클릭 헤테로아릴의 에테르 유도체 - Google Patents
비시클릭 헤테로아릴의 에테르 유도체 Download PDFInfo
- Publication number
- KR20120093867A KR20120093867A KR1020127009095A KR20127009095A KR20120093867A KR 20120093867 A KR20120093867 A KR 20120093867A KR 1020127009095 A KR1020127009095 A KR 1020127009095A KR 20127009095 A KR20127009095 A KR 20127009095A KR 20120093867 A KR20120093867 A KR 20120093867A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- amino
- mmol
- pyrrolo
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 125000000217 alkyl group Chemical group 0.000 claims description 150
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 49
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- 125000004429 atom Chemical group 0.000 claims description 37
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- 125000006563 (C1-3) alkylaminocarbonyl group Chemical group 0.000 claims description 3
- IXDDSQBFYZXHOB-MUABAYHSSA-N C1CN(S(=O)(=O)C)CCN1[C@@H]1C[C@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC45CCC(CC4)O5)C=CC=3)=C2)C1 Chemical compound C1CN(S(=O)(=O)C)CCN1[C@@H]1C[C@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC45CCC(CC4)O5)C=CC=3)=C2)C1 IXDDSQBFYZXHOB-MUABAYHSSA-N 0.000 claims description 3
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- YJHXUGJSFWZTRI-RZUKLDMISA-N NC(=O)[C@@H]1CCCN1C[C@@H]1C[C@@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC45CCC(CC4)O5)C=CC=3)=C2)C1 Chemical compound NC(=O)[C@@H]1CCCN1C[C@@H]1C[C@@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC45CCC(CC4)O5)C=CC=3)=C2)C1 YJHXUGJSFWZTRI-RZUKLDMISA-N 0.000 claims description 3
- YJHXUGJSFWZTRI-XZMHDNNLSA-N NC(=O)[C@H]1CCCN1C[C@@H]1C[C@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC45CCC(CC4)O5)C=CC=3)=C2)C1 Chemical compound NC(=O)[C@H]1CCCN1C[C@@H]1C[C@H](N2C3=NC=NC(N)=C3C(C=3C=C(OCC45CCC(CC4)O5)C=CC=3)=C2)C1 YJHXUGJSFWZTRI-XZMHDNNLSA-N 0.000 claims description 3
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- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 3
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- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 3
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- 125000003831 tetrazolyl group Chemical group 0.000 claims description 3
- CBQODGRJHHJAEC-UHFFFAOYSA-N 5-[3-(7-oxabicyclo[2.2.1]heptan-4-ylmethoxy)phenyl]-7-[3-[(1-oxo-1,4-thiazinan-4-yl)methyl]cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound C1=C(C=2C=C(OCC34CCC(CC3)O4)C=CC=2)C=2C(N)=NC=NC=2N1C(C1)CC1CN1CCS(=O)CC1 CBQODGRJHHJAEC-UHFFFAOYSA-N 0.000 claims description 2
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- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims description 2
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- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/2022—Organic macromolecular compounds
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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|---|---|---|---|
| US24118209P | 2009-09-10 | 2009-09-10 | |
| US61/241,182 | 2009-09-10 |
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| KR20120093867A true KR20120093867A (ko) | 2012-08-23 |
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Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20120165310A1 (enExample) |
| EP (1) | EP2475668A1 (enExample) |
| JP (1) | JP2013504543A (enExample) |
| KR (1) | KR20120093867A (enExample) |
| CN (1) | CN102596963A (enExample) |
| AU (1) | AU2010294209A1 (enExample) |
| BR (1) | BR112012005400A2 (enExample) |
| CA (1) | CA2773661A1 (enExample) |
| EA (1) | EA201200471A1 (enExample) |
| IN (1) | IN2012DN02139A (enExample) |
| MX (1) | MX2012002997A (enExample) |
| WO (1) | WO2011029915A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9290499B2 (en) | 2010-05-19 | 2016-03-22 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| WO2013052417A1 (en) | 2011-10-03 | 2013-04-11 | The University Of North Carolina At Chapel Hill | Pyrrolopyrimidine compounds for the treatment of cancer |
| CN104080789B (zh) * | 2012-01-31 | 2016-05-11 | 南京奥昭生物科技有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| TW201348231A (zh) * | 2012-02-29 | 2013-12-01 | Amgen Inc | 雜雙環化合物 |
| RU2014145121A (ru) | 2012-05-22 | 2016-07-10 | Зэ Юниверсити Оф Норд Каролина Эт Чапел Хилл | Пиримидиновые соединения для лечения злокачественной опухоли |
| EP2909211A4 (en) | 2012-10-17 | 2016-06-22 | Univ North Carolina | PYRAZOLOPYRIMIDINE COMPOUNDS FOR CANCER TREATMENT |
| CN104854101B (zh) | 2012-11-06 | 2018-05-01 | 上海复尚慧创医药研究有限公司 | Alk激酶抑制剂 |
| EP2925752A4 (en) | 2012-11-27 | 2016-06-01 | Univ North Carolina | PYRIMIDINE COMPOUNDS FOR CANCER TREATMENT |
| WO2015157122A1 (en) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrazolopyrimidine compounds |
| CA3006966A1 (en) * | 2015-12-02 | 2017-06-08 | Astraea Therapeutics, Llc | Piperidinyl nociceptin receptor compounds |
| US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
| CN106008527B (zh) * | 2016-06-29 | 2018-05-15 | 四川大学华西医院 | 吡唑并[3,4-d]嘧啶衍生物 |
| CN107098909B (zh) * | 2017-05-19 | 2019-02-22 | 四川大学华西医院 | 烷氧端基寡peg修饰的氨基嘧啶衍生物及抗肿瘤应用 |
| CA3169649A1 (en) * | 2020-01-30 | 2021-08-05 | The Regents Of The University Of California | Strad-binding agents and uses thereof |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
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-
2010
- 2010-09-10 WO PCT/EP2010/063334 patent/WO2011029915A1/en not_active Ceased
- 2010-09-10 KR KR1020127009095A patent/KR20120093867A/ko not_active Withdrawn
- 2010-09-10 CN CN2010800506564A patent/CN102596963A/zh active Pending
- 2010-09-10 BR BR112012005400A patent/BR112012005400A2/pt not_active Application Discontinuation
- 2010-09-10 EP EP10763143A patent/EP2475668A1/en not_active Withdrawn
- 2010-09-10 CA CA2773661A patent/CA2773661A1/en not_active Abandoned
- 2010-09-10 US US13/394,534 patent/US20120165310A1/en not_active Abandoned
- 2010-09-10 MX MX2012002997A patent/MX2012002997A/es not_active Application Discontinuation
- 2010-09-10 JP JP2012528376A patent/JP2013504543A/ja active Pending
- 2010-09-10 EA EA201200471A patent/EA201200471A1/ru unknown
- 2010-09-10 AU AU2010294209A patent/AU2010294209A1/en not_active Abandoned
- 2010-09-10 IN IN2139DEN2012 patent/IN2012DN02139A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201200471A1 (ru) | 2012-10-30 |
| AU2010294209A1 (en) | 2012-03-29 |
| CA2773661A1 (en) | 2011-03-17 |
| CN102596963A (zh) | 2012-07-18 |
| WO2011029915A1 (en) | 2011-03-17 |
| JP2013504543A (ja) | 2013-02-07 |
| MX2012002997A (es) | 2012-08-01 |
| BR112012005400A2 (pt) | 2016-04-05 |
| EP2475668A1 (en) | 2012-07-18 |
| US20120165310A1 (en) | 2012-06-28 |
| IN2012DN02139A (enExample) | 2015-08-07 |
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