KR20120092141A - 시르투인 조절제로서의 비시클릭 피리딘 및 유사체 - Google Patents
시르투인 조절제로서의 비시클릭 피리딘 및 유사체 Download PDFInfo
- Publication number
- KR20120092141A KR20120092141A KR1020127013635A KR20127013635A KR20120092141A KR 20120092141 A KR20120092141 A KR 20120092141A KR 1020127013635 A KR1020127013635 A KR 1020127013635A KR 20127013635 A KR20127013635 A KR 20127013635A KR 20120092141 A KR20120092141 A KR 20120092141A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- substituted
- fluoro
- compound
- sirtuin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *c1ccc(C(F)F)cc1 Chemical compound *c1ccc(C(F)F)cc1 0.000 description 6
- VNVOKDXCMDZIIU-UHFFFAOYSA-N CC(Oc1c(C)cc[n+]([O-])c1)=O Chemical compound CC(Oc1c(C)cc[n+]([O-])c1)=O VNVOKDXCMDZIIU-UHFFFAOYSA-N 0.000 description 2
- XPSGHEQJUZODNK-UHFFFAOYSA-N CCOC(CCNc1nc(Cl)ccc1[N+]([O-])=O)=O Chemical compound CCOC(CCNc1nc(Cl)ccc1[N+]([O-])=O)=O XPSGHEQJUZODNK-UHFFFAOYSA-N 0.000 description 2
- VDUHWTPOEVEMFY-UHFFFAOYSA-N COc1c(N)nc(-c2cc(F)ccc2)nc1Cl Chemical compound COc1c(N)nc(-c2cc(F)ccc2)nc1Cl VDUHWTPOEVEMFY-UHFFFAOYSA-N 0.000 description 2
- AHROXRWYYLKGGH-UHFFFAOYSA-N Bc(cc1C)nc([N+]([O-])=O)c1OCC([O]1(CC)CC1)=O Chemical compound Bc(cc1C)nc([N+]([O-])=O)c1OCC([O]1(CC)CC1)=O AHROXRWYYLKGGH-UHFFFAOYSA-N 0.000 description 1
- ORAAJQLOGZEJMS-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1c1c2OCCN(C(Nc3ccncc3)=O)c2nc(-c2cccc(F)c2)n1)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1c1c2OCCN(C(Nc3ccncc3)=O)c2nc(-c2cccc(F)c2)n1)=O ORAAJQLOGZEJMS-UHFFFAOYSA-N 0.000 description 1
- QTUBQNWAXAFMCB-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1c1nc(-c2cc(F)ccc2)nc2c1OCCN2)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1c1nc(-c2cc(F)ccc2)nc2c1OCCN2)=O QTUBQNWAXAFMCB-UHFFFAOYSA-N 0.000 description 1
- HKPBWQUDQVWFLF-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)c2nc(-c3cc(C(F)(F)F)ccc3)ccc2C1(C)O)=O Chemical compound CC(C)(C)OC(N(CC1)c2nc(-c3cc(C(F)(F)F)ccc3)ccc2C1(C)O)=O HKPBWQUDQVWFLF-UHFFFAOYSA-N 0.000 description 1
- KJEOAAPSFQZGQJ-UHFFFAOYSA-N CC(C)(C)OC(N(CCC1)c2nc(Cl)ccc2C1=O)=O Chemical compound CC(C)(C)OC(N(CCC1)c2nc(Cl)ccc2C1=O)=O KJEOAAPSFQZGQJ-UHFFFAOYSA-N 0.000 description 1
- IRSVDPRIUKSVFH-UHFFFAOYSA-N CC(C)(C)OC(N1c2nc(Cl)ccc2CCCC1)=O Chemical compound CC(C)(C)OC(N1c2nc(Cl)ccc2CCCC1)=O IRSVDPRIUKSVFH-UHFFFAOYSA-N 0.000 description 1
- WZDMEUOIVUZTPB-UHFFFAOYSA-N CC(C)(C)OC(Nc1nc(Br)ccc1)=O Chemical compound CC(C)(C)OC(Nc1nc(Br)ccc1)=O WZDMEUOIVUZTPB-UHFFFAOYSA-N 0.000 description 1
- PPXFLANYGWXACK-UHFFFAOYSA-N CC(C)(C)OC(Nc1nc(N2COCCC2)ccc1)=O Chemical compound CC(C)(C)OC(Nc1nc(N2COCCC2)ccc1)=O PPXFLANYGWXACK-UHFFFAOYSA-N 0.000 description 1
- KLRCTUOHTMRIQJ-UHFFFAOYSA-N CC1=CCNc2c1ccc(-c1cccc(C(F)(F)F)c1)n2 Chemical compound CC1=CCNc2c1ccc(-c1cccc(C(F)(F)F)c1)n2 KLRCTUOHTMRIQJ-UHFFFAOYSA-N 0.000 description 1
- CCLSAEXHEUDNJO-UHFFFAOYSA-N CCOC(c1cccc(N2CCOCC2)n1)=O Chemical compound CCOC(c1cccc(N2CCOCC2)n1)=O CCLSAEXHEUDNJO-UHFFFAOYSA-N 0.000 description 1
- YCPHTTJYZGPHIS-UHFFFAOYSA-N COC([n](cc1)c2c1ccc(Cl)n2)=O Chemical compound COC([n](cc1)c2c1ccc(Cl)n2)=O YCPHTTJYZGPHIS-UHFFFAOYSA-N 0.000 description 1
- IWYYIZOHWPCALJ-UHFFFAOYSA-N Cc(cc1)cc[n+]1[O-] Chemical compound Cc(cc1)cc[n+]1[O-] IWYYIZOHWPCALJ-UHFFFAOYSA-N 0.000 description 1
- IKNQPNLSEBWZKX-UHFFFAOYSA-N Cc(cc1Cl)ccc1F Chemical compound Cc(cc1Cl)ccc1F IKNQPNLSEBWZKX-UHFFFAOYSA-N 0.000 description 1
- UHIGHLGTNVYXOP-UHFFFAOYSA-N Cc(cc1F)cc(F)c1F Chemical compound Cc(cc1F)cc(F)c1F UHIGHLGTNVYXOP-UHFFFAOYSA-N 0.000 description 1
- YISYUYYETHYYMD-UHFFFAOYSA-N Cc1cc(F)cc(F)c1 Chemical compound Cc1cc(F)cc(F)c1 YISYUYYETHYYMD-UHFFFAOYSA-N 0.000 description 1
- LTEOEYXSGUFFOT-UHFFFAOYSA-N Cc1cc(S)nc([N+]([O-])=O)c1O Chemical compound Cc1cc(S)nc([N+]([O-])=O)c1O LTEOEYXSGUFFOT-UHFFFAOYSA-N 0.000 description 1
- KKPCPGWGLHHNSW-UHFFFAOYSA-N Cc1cccc(CN2CCOCC2)c1 Chemical compound Cc1cccc(CN2CCOCC2)c1 KKPCPGWGLHHNSW-UHFFFAOYSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- WYOZXMYWGIJYSQ-UHFFFAOYSA-N Cc1ccncc1O Chemical compound Cc1ccncc1O WYOZXMYWGIJYSQ-UHFFFAOYSA-N 0.000 description 1
- HJFSLDGQZGTDTI-UHFFFAOYSA-N FC(c1cc(-c(cc2)nc3c2OCCCN3)ccc1)(F)F Chemical compound FC(c1cc(-c(cc2)nc3c2OCCCN3)ccc1)(F)F HJFSLDGQZGTDTI-UHFFFAOYSA-N 0.000 description 1
- JZXXNZXELIFQRB-UHFFFAOYSA-N FC(c1cc(-c(cc2)nc3c2OCCN3)ccc1)(F)F Chemical compound FC(c1cc(-c(cc2)nc3c2OCCN3)ccc1)(F)F JZXXNZXELIFQRB-UHFFFAOYSA-N 0.000 description 1
- XJXVTLRKVJBWFN-UHFFFAOYSA-N Fc1ccc(C2CC2)cc1F Chemical compound Fc1ccc(C2CC2)cc1F XJXVTLRKVJBWFN-UHFFFAOYSA-N 0.000 description 1
- FFNVQNRYTPFDDP-UHFFFAOYSA-N N#Cc1ncccc1 Chemical compound N#Cc1ncccc1 FFNVQNRYTPFDDP-UHFFFAOYSA-N 0.000 description 1
- OBFHWMAYVILOEL-UHFFFAOYSA-N NC(C1)C1c1ccccn1 Chemical compound NC(C1)C1c1ccccn1 OBFHWMAYVILOEL-UHFFFAOYSA-N 0.000 description 1
- RNFJALLDQOKANN-UHFFFAOYSA-N Nc(nc(-c1cccc(F)c1)nc1Cl)c1O Chemical compound Nc(nc(-c1cccc(F)c1)nc1Cl)c1O RNFJALLDQOKANN-UHFFFAOYSA-N 0.000 description 1
- PEARXTWZZWZJJN-UHFFFAOYSA-N O=C(CCNc1n2)Nc1ccc2Cl Chemical compound O=C(CCNc1n2)Nc1ccc2Cl PEARXTWZZWZJJN-UHFFFAOYSA-N 0.000 description 1
- IMWIJVGXQMUREK-UHFFFAOYSA-N O=C(Nc1ncc[s]1)N1c2nc(-c3cc(C(F)(F)F)ccc3)ccc2OCC1 Chemical compound O=C(Nc1ncc[s]1)N1c2nc(-c3cc(C(F)(F)F)ccc3)ccc2OCC1 IMWIJVGXQMUREK-UHFFFAOYSA-N 0.000 description 1
- SAZSDHZXRMXESN-UHFFFAOYSA-N OC(c1cccc(N2CCOCC2)n1)=O Chemical compound OC(c1cccc(N2CCOCC2)n1)=O SAZSDHZXRMXESN-UHFFFAOYSA-N 0.000 description 1
- SHCWQWRTKPNTEM-UHFFFAOYSA-N [O-][N+](c(ccc(Cl)n1)c1Cl)=O Chemical compound [O-][N+](c(ccc(Cl)n1)c1Cl)=O SHCWQWRTKPNTEM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25626909P | 2009-10-29 | 2009-10-29 | |
| US61/256,269 | 2009-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20120092141A true KR20120092141A (ko) | 2012-08-20 |
Family
ID=43991957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127013635A Ceased KR20120092141A (ko) | 2009-10-29 | 2010-10-29 | 시르투인 조절제로서의 비시클릭 피리딘 및 유사체 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9556201B2 (enExample) |
| EP (1) | EP2493888B1 (enExample) |
| JP (1) | JP2013509442A (enExample) |
| KR (1) | KR20120092141A (enExample) |
| CN (1) | CN102725291B (enExample) |
| AU (1) | AU2010319842A1 (enExample) |
| BR (1) | BR112012010010A2 (enExample) |
| CA (1) | CA2779303A1 (enExample) |
| ES (1) | ES2574927T3 (enExample) |
| IL (1) | IL219372A0 (enExample) |
| IN (1) | IN2012DN03799A (enExample) |
| MX (1) | MX2012004995A (enExample) |
| RU (1) | RU2550821C2 (enExample) |
| WO (1) | WO2011059839A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0820669A2 (pt) | 2007-12-10 | 2020-08-04 | Novartis Ag | compostos orgânicos |
| CA2738794C (en) | 2008-09-29 | 2016-01-05 | Sirtris Pharmaceuticals, Inc. | Chromenone analogs as sirtuin modulators |
| EA029892B1 (ru) | 2012-04-25 | 2018-05-31 | Такеда Фармасьютикал Компани Лимитед | Азотсодержащее гетероциклическое соединение |
| EP2847198B1 (en) | 2012-05-08 | 2016-12-14 | Lycera Corporation | Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of ror-gamma and the treatment of disease |
| RU2014149136A (ru) | 2012-05-08 | 2016-07-10 | Мерк Шарп И Доум Корп. | ТЕТРАГИДРОНАФТИРИДИНОВЫЕ И РОДСТВЕННЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORγ АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ |
| JP6205356B2 (ja) | 2012-07-13 | 2017-09-27 | 武田薬品工業株式会社 | 複素環化合物 |
| EP2890698B1 (en) * | 2012-08-30 | 2017-03-01 | F. Hoffmann-La Roche AG | Dioxino- and oxazin-[2,3-d]pyrimidine pi3k inhibitor compounds and methods of use |
| CN102977117A (zh) * | 2012-11-26 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 一种6-溴-2,2-二甲基-2h-吡啶并[3,2-b][1,4]恶嗪-3(4h)-酮的合成方法 |
| GEP201606554B (en) * | 2012-12-26 | 2016-10-10 | Takeda Pharmaceuticals Co | Nitrogenated heterocyclic compound |
| EP2975031A4 (en) | 2013-03-14 | 2017-04-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| JP6376707B2 (ja) | 2013-05-13 | 2018-08-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | サーチュイン調節剤としての置換架橋尿素類似体 |
| WO2016081692A2 (en) * | 2014-11-19 | 2016-05-26 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
| JP6411342B2 (ja) | 2013-07-03 | 2018-10-24 | 武田薬品工業株式会社 | アミド化合物 |
| EP3018126A4 (en) | 2013-07-03 | 2016-12-07 | Takeda Pharmaceuticals Co | HETEROCYCLIC CONNECTION |
| DK3929196T3 (da) | 2013-09-24 | 2023-09-25 | Fujifilm Corp | Farmaceutisk sammensætning af en nitrogenholdig forbindelse eller salt deraf, eller metalkompleks deraf |
| US10172915B2 (en) | 2013-10-20 | 2019-01-08 | Duke University | Methods and compositions for activation of sirtuins with Annexin A1 peptides |
| CN105683188B (zh) | 2013-10-25 | 2018-02-09 | 诺华股份有限公司 | 作为fgfr4抑制剂的稠环二环吡啶基衍生物 |
| WO2015095795A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| WO2015095788A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
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| EP2493888A4 (en) | 2013-05-01 |
| EP2493888B1 (en) | 2016-04-06 |
| WO2011059839A1 (en) | 2011-05-19 |
| BR112012010010A2 (pt) | 2018-03-20 |
| CN102725291A (zh) | 2012-10-10 |
| CN102725291B (zh) | 2016-12-21 |
| ES2574927T3 (es) | 2016-06-23 |
| IL219372A0 (en) | 2012-06-28 |
| CA2779303A1 (en) | 2011-05-19 |
| RU2550821C2 (ru) | 2015-05-20 |
| MX2012004995A (es) | 2012-10-03 |
| AU2010319842A1 (en) | 2012-05-17 |
| JP2013509442A (ja) | 2013-03-14 |
| IN2012DN03799A (enExample) | 2015-08-28 |
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