KR20120007540A - ＰＩ3 키나제 및/또는 ｍＴＯＲ의 억제제 - Google Patents
ＰＩ3 키나제 및/또는 ｍＴＯＲ의 억제제 Download PDFInfo
- Publication number
- KR20120007540A KR20120007540A KR1020117028155A KR20117028155A KR20120007540A KR 20120007540 A KR20120007540 A KR 20120007540A KR 1020117028155 A KR1020117028155 A KR 1020117028155A KR 20117028155 A KR20117028155 A KR 20117028155A KR 20120007540 A KR20120007540 A KR 20120007540A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- amino
- pyridinyl
- triazin
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17352009P | 2009-04-28 | 2009-04-28 | |
| US61/173,520 | 2009-04-28 | ||
| US25853209P | 2009-11-05 | 2009-11-05 | |
| US61/258,532 | 2009-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20120007540A true KR20120007540A (ko) | 2012-01-20 |
Family
ID=42315845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117028155A Withdrawn KR20120007540A (ko) | 2009-04-28 | 2010-04-27 | ＰＩ3 키나제 및/또는 ｍＴＯＲ의 억제제 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8362241B2 (https=) |
| EP (1) | EP2424859B1 (https=) |
| JP (1) | JP5697662B2 (https=) |
| KR (1) | KR20120007540A (https=) |
| CN (1) | CN102548984B (https=) |
| AR (1) | AR076486A1 (https=) |
| AU (1) | AU2010241723B2 (https=) |
| BR (1) | BRPI1015262A2 (https=) |
| CA (1) | CA2758986C (https=) |
| CL (1) | CL2011002691A1 (https=) |
| CO (1) | CO6440596A2 (https=) |
| CR (1) | CR20110634A (https=) |
| EA (1) | EA019700B1 (https=) |
| IL (1) | IL215731A0 (https=) |
| MA (1) | MA34207B1 (https=) |
| MX (1) | MX2011011335A (https=) |
| NZ (1) | NZ595572A (https=) |
| PE (1) | PE20121159A1 (https=) |
| SG (1) | SG175364A1 (https=) |
| TW (1) | TW201103902A (https=) |
| UY (1) | UY32582A (https=) |
| WO (1) | WO2010126895A1 (https=) |
| ZA (1) | ZA201108101B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017135589A1 (ko) * | 2016-02-03 | 2017-08-10 | 삼진제약주식회사 | 라프 키나제 및 혈관내피성장인자 수용체를 저해하는 피리딘 유도체, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이의 용도 |
| KR20210113868A (ko) * | 2020-03-09 | 2021-09-17 | 삼성중공업 주식회사 | 선박용 볼라드 |
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| JP5599783B2 (ja) | 2008-05-30 | 2014-10-01 | アムジエン・インコーポレーテツド | Ｐｉ３キナーゼの阻害薬 |
| MX2011009796A (es) | 2009-03-20 | 2011-12-14 | Amgen Inc | Inhibidores de la cinasa pi3. |
| UY32582A (es) * | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
| PL2647637T3 (pl) * | 2010-12-02 | 2016-06-30 | Medpacto Inc | Pochodna purynylopirydynyloamino-2,4-dlfluorofenylo-sulfonamidu, jej farmaceutycznie dopuszczalna sól, sposób jej wytwarzania oraz zawierająca ją jako składnik aktywny kompozycja farmaceutyczna o aktywności hamującej kinazę Raf |
| EP2675816A4 (en) * | 2011-02-14 | 2014-08-13 | Univ Alberta | BORIC ACID CATALYSTS AND USE METHOD FOR THE ACTIVATION AND TRANSFORMATION OF CARBOXYLIC ACIDS |
| EP2683243A4 (en) * | 2011-03-09 | 2014-12-03 | Celgene Avilomics Res Inc | PI3 KINASE INHIBITORS AND USES THEREOF |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| KR20180084153A (ko) | 2011-06-10 | 2018-07-24 | 메르크 파텐트 게엠베하 | Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법 |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| CN103102349B (zh) * | 2011-11-14 | 2017-03-15 | 北京赛林泰医药技术有限公司 | 蛋白激酶抑制剂及其组合物和用途 |
| KR101721739B1 (ko) * | 2011-11-14 | 2017-03-30 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 키나제 조절 화합물, 이를 함유하는 조성물 및 그의 용도 |
| FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
| EP2617718A1 (en) | 2012-01-20 | 2013-07-24 | Sanofi | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent |
| US9221778B2 (en) | 2012-02-13 | 2015-12-29 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
| US9249119B2 (en) * | 2012-02-14 | 2016-02-02 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
| US9382223B2 (en) | 2012-02-22 | 2016-07-05 | Sanofi | Process for preparation of dronedarone by oxidation of a hydroxyl group |
| WO2013178337A1 (en) | 2012-05-31 | 2013-12-05 | Sanofi | Process for preparation of dronedarone by grignard reaction |
| HK1206331A1 (en) * | 2012-08-09 | 2016-01-08 | Neuropore Therapies, Inc. | Aryl-and heteroaryl-substituted benzene derivatives as modulators of pi3-kinase signalling pathways |
| FR2994572B1 (fr) * | 2012-08-17 | 2015-04-17 | Centre Nat Rech Scient | Pyrido[3,2-d]pyrimidines trisubstituees, leurs procedes de preparation et leurs utilisation en therapeutique |
| US20160002185A1 (en) | 2013-02-19 | 2016-01-07 | Amgen Inc. | Cis-morpholinone and other compounds as mdm2 inhibitors for the treatment of cancer |
| AU2014236812B2 (en) | 2013-03-14 | 2018-03-01 | Amgen Inc. | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
| WO2014177915A1 (en) | 2013-05-01 | 2014-11-06 | Piramal Enterprises Limited | Cancer combination therapy using imidazo[4,5-c]quinoline derivatives |
| CN105358530A (zh) | 2013-06-10 | 2016-02-24 | 美国安进公司 | 制备mdm2抑制剂的方法及其结晶形式 |
| CN105764501A (zh) | 2013-07-26 | 2016-07-13 | 现代化制药公司 | 改善比生群治疗效益的组合物 |
| CN104513235B (zh) * | 2013-09-02 | 2017-12-05 | 广东东阳光药业有限公司 | 取代的氨基嘧啶类化合物及其使用方法和用途 |
| SG10201802061TA (en) * | 2013-09-25 | 2018-05-30 | Vertex Pharma | A selective inhibitor of phosphatidylinositol 3-kinase-gamma |
| HRP20220718T1 (hr) | 2013-11-11 | 2022-09-30 | Amgen Inc. | Kombinacijska terapija uključujući inhibitor mdm2 i jedan ili više dodatnih farmaceutski aktivnih sredstava za liječenje raka |
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- 2010-04-27 JP JP2012508595A patent/JP5697662B2/ja active Active
- 2010-04-27 US US12/768,602 patent/US8362241B2/en active Active
- 2010-04-27 SG SG2011078748A patent/SG175364A1/en unknown
- 2010-04-27 EP EP10718364.2A patent/EP2424859B1/en active Active
- 2010-04-27 NZ NZ595572A patent/NZ595572A/xx not_active IP Right Cessation
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- 2010-04-27 CA CA2758986A patent/CA2758986C/en active Active
- 2010-04-27 MX MX2011011335A patent/MX2011011335A/es active IP Right Grant
- 2010-04-27 KR KR1020117028155A patent/KR20120007540A/ko not_active Withdrawn
- 2010-04-27 CN CN201080030184.6A patent/CN102548984B/zh not_active Expired - Fee Related
- 2010-04-27 BR BRPI1015262A patent/BRPI1015262A2/pt not_active IP Right Cessation
- 2010-04-27 EA EA201101583A patent/EA019700B1/ru not_active IP Right Cessation
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- 2011-10-28 CL CL2011002691A patent/CL2011002691A1/es unknown
- 2011-11-04 ZA ZA2011/08101A patent/ZA201108101B/en unknown
- 2011-11-25 MA MA34389A patent/MA34207B1/fr unknown
- 2011-11-28 CR CR20110634A patent/CR20110634A/es unknown
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- 2012-11-19 US US13/681,230 patent/US8772480B2/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017135589A1 (ko) * | 2016-02-03 | 2017-08-10 | 삼진제약주식회사 | 라프 키나제 및 혈관내피성장인자 수용체를 저해하는 피리딘 유도체, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이의 용도 |
| CN109071543A (zh) * | 2016-02-03 | 2018-12-21 | 三进制药株式会社 | 抑制raf激酶和血管内皮生长因子受体的吡啶衍生物，其制备方法，含有其的药物组合物及其用途 |
| US10844062B2 (en) | 2016-02-03 | 2020-11-24 | Incheon University Industry Academic Cooperation Foundation | Pyridine derivative inhibiting RAF kinase and vascular endothelial growth factor receptor, method for preparing same, pharmaceutical composition containing same, and use thereof |
| CN109071543B (zh) * | 2016-02-03 | 2021-07-16 | 三进制药株式会社 | 抑制raf激酶和血管内皮生长因子受体的吡啶衍生物，其制备方法，含有其的药物组合物及其用途 |
| KR20210113868A (ko) * | 2020-03-09 | 2021-09-17 | 삼성중공업 주식회사 | 선박용 볼라드 |
Also Published As
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| CO6440596A2 (es) | 2012-05-15 |
| ZA201108101B (en) | 2012-07-25 |
| MX2011011335A (es) | 2011-11-18 |
| WO2010126895A1 (en) | 2010-11-04 |
| CL2011002691A1 (es) | 2012-03-16 |
| JP2012525395A (ja) | 2012-10-22 |
| US20130079303A1 (en) | 2013-03-28 |
| AU2010241723A1 (en) | 2011-11-17 |
| SG175364A1 (en) | 2011-11-28 |
| EA019700B1 (ru) | 2014-05-30 |
| AR076486A1 (es) | 2011-06-15 |
| EP2424859B1 (en) | 2015-04-08 |
| BRPI1015262A2 (pt) | 2016-05-03 |
| TW201103902A (en) | 2011-02-01 |
| PE20121159A1 (es) | 2012-09-19 |
| CA2758986A1 (en) | 2010-11-04 |
| JP5697662B2 (ja) | 2015-04-08 |
| EA201101583A1 (ru) | 2012-05-30 |
| US8362241B2 (en) | 2013-01-29 |
| US20100273764A1 (en) | 2010-10-28 |
| CA2758986C (en) | 2014-05-27 |
| CN102548984A (zh) | 2012-07-04 |
| US8772480B2 (en) | 2014-07-08 |
| EP2424859A1 (en) | 2012-03-07 |
| AU2010241723B2 (en) | 2012-12-13 |
| HK1167862A1 (en) | 2012-12-14 |
| UY32582A (es) | 2010-11-30 |
| CN102548984B (zh) | 2015-11-25 |
| IL215731A0 (en) | 2012-01-31 |
| CR20110634A (es) | 2012-01-06 |
| NZ595572A (en) | 2013-07-26 |
| MA34207B1 (fr) | 2013-05-02 |
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