KR20110097996A - 에탄아민 화합물 및 우울증의 치료를 위한 그의 용도 - Google Patents
에탄아민 화합물 및 우울증의 치료를 위한 그의 용도 Download PDFInfo
- Publication number
- KR20110097996A KR20110097996A KR1020117017236A KR20117017236A KR20110097996A KR 20110097996 A KR20110097996 A KR 20110097996A KR 1020117017236 A KR1020117017236 A KR 1020117017236A KR 20117017236 A KR20117017236 A KR 20117017236A KR 20110097996 A KR20110097996 A KR 20110097996A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- pharmaceutically acceptable
- pyridin
- propan
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 42
- 208000020401 Depressive disease Diseases 0.000 title claims abstract description 6
- 150000001875 compounds Chemical class 0.000 title claims description 138
- 150000003839 salts Chemical class 0.000 claims abstract description 110
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- JCABFPBDEZEFKI-UHFFFAOYSA-N 1-(3-fluorophenyl)-2-methyl-2-pyridin-2-ylpropan-1-amine Chemical compound C=1C=CC=NC=1C(C)(C)C(N)C1=CC=CC(F)=C1 JCABFPBDEZEFKI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 58
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- 239000002671 adjuvant Substances 0.000 claims description 24
- IFOJJUKSLKNAOM-AWEZNQCLSA-N (1s)-2-methyl-1-phenyl-2-pyridin-2-ylpropan-1-amine Chemical compound C1([C@H](N)C(C)(C)C=2N=CC=CC=2)=CC=CC=C1 IFOJJUKSLKNAOM-AWEZNQCLSA-N 0.000 claims description 12
- JCABFPBDEZEFKI-CQSZACIVSA-N (1r)-1-(3-fluorophenyl)-2-methyl-2-pyridin-2-ylpropan-1-amine Chemical compound C1([C@@H](N)C(C)(C)C=2N=CC=CC=2)=CC=CC(F)=C1 JCABFPBDEZEFKI-CQSZACIVSA-N 0.000 claims description 10
- IFOJJUKSLKNAOM-CQSZACIVSA-N (1r)-2-methyl-1-phenyl-2-pyridin-2-ylpropan-1-amine Chemical compound C1([C@@H](N)C(C)(C)C=2N=CC=CC=2)=CC=CC=C1 IFOJJUKSLKNAOM-CQSZACIVSA-N 0.000 claims description 10
- JCABFPBDEZEFKI-AWEZNQCLSA-N (1s)-1-(3-fluorophenyl)-2-methyl-2-pyridin-2-ylpropan-1-amine Chemical compound C1([C@H](N)C(C)(C)C=2N=CC=CC=2)=CC=CC(F)=C1 JCABFPBDEZEFKI-AWEZNQCLSA-N 0.000 claims description 10
- MAKZOTAGHBIOMS-KZHAMYRLSA-N (e)-but-2-enedioic acid;(1s)-2-methyl-1-phenyl-2-pyridin-2-ylpropan-1-amine Chemical compound OC(=O)\C=C\C(O)=O.C1([C@H](N)C(C)(C)C=2N=CC=CC=2)=CC=CC=C1 MAKZOTAGHBIOMS-KZHAMYRLSA-N 0.000 claims description 9
- IMFYGXNQBXJCAN-WZGZYPNHSA-N (e)-but-2-enedioic acid;(1r)-1-(3-fluorophenyl)-2-methyl-2-pyridin-2-ylpropan-1-amine Chemical compound OC(=O)\C=C\C(O)=O.C1([C@@H](N)C(C)(C)C=2N=CC=CC=2)=CC=CC(F)=C1 IMFYGXNQBXJCAN-WZGZYPNHSA-N 0.000 claims description 7
- MAKZOTAGHBIOMS-WZGZYPNHSA-N (e)-but-2-enedioic acid;(1r)-2-methyl-1-phenyl-2-pyridin-2-ylpropan-1-amine Chemical compound OC(=O)\C=C\C(O)=O.C1([C@@H](N)C(C)(C)C=2N=CC=CC=2)=CC=CC=C1 MAKZOTAGHBIOMS-WZGZYPNHSA-N 0.000 claims description 7
- IMFYGXNQBXJCAN-KZHAMYRLSA-N (e)-but-2-enedioic acid;(1s)-1-(3-fluorophenyl)-2-methyl-2-pyridin-2-ylpropan-1-amine Chemical compound OC(=O)\C=C\C(O)=O.C1([C@H](N)C(C)(C)C=2N=CC=CC=2)=CC=CC(F)=C1 IMFYGXNQBXJCAN-KZHAMYRLSA-N 0.000 claims description 7
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- MAKZOTAGHBIOMS-WLHGVMLRSA-N (e)-but-2-enedioic acid;2-methyl-1-phenyl-2-pyridin-2-ylpropan-1-amine Chemical compound OC(=O)\C=C\C(O)=O.C=1C=CC=NC=1C(C)(C)C(N)C1=CC=CC=C1 MAKZOTAGHBIOMS-WLHGVMLRSA-N 0.000 claims description 7
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract description 9
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Confectionery (AREA)
Applications Claiming Priority (2)
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| US14067308P | 2008-12-24 | 2008-12-24 | |
| US61/140,673 | 2008-12-24 |
Publications (1)
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| KR20110097996A true KR20110097996A (ko) | 2011-08-31 |
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| KR20110097996A (ko) * | 2008-12-24 | 2011-08-31 | 아스트라제네카 아베 | 에탄아민 화합물 및 우울증의 치료를 위한 그의 용도 |
| CN112279843B (zh) * | 2020-11-24 | 2023-05-16 | 深圳市第二人民医院(深圳市转化医学研究院) | 一种具有抗抑郁活性的含氮杂环化合物 |
| CN112250676B (zh) * | 2020-11-24 | 2023-05-16 | 深圳市第二人民医院(深圳市转化医学研究院) | 一种具有抗抑郁活性的含氧杂环化合物 |
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| US3422191A (en) | 1965-01-21 | 1969-01-14 | Synergistics Inc | Compositions and methods for tranquilization employing salts of n-morpholine ethanol |
| GB1427026A (en) | 1972-11-20 | 1976-03-03 | Ici Ltd | Synthetic film materials |
| JPS5756474B2 (enExample) | 1973-05-26 | 1982-11-30 | ||
| GB9320273D0 (en) | 1993-04-01 | 1993-11-17 | Fisons Corp | Compound useful in therapy |
| US5455259A (en) | 1987-02-06 | 1995-10-03 | Fisons Corporation | Compounds for the treatment of neurodegenerative disorders |
| ES2083972T3 (es) | 1988-08-12 | 1996-05-01 | Astra Ab | Arilalquil-aminas y -amidas con propiedades anticonvulsivas y neuroprotectoras. |
| JP2514855B2 (ja) | 1990-08-08 | 1996-07-10 | キッセイ薬品工業株式会社 | 光学活性なアラニンアニリド誘導体の酸付加塩 |
| US5206248A (en) | 1992-03-27 | 1993-04-27 | Smith Richard A | Method for reducing emotional lability |
| ES2142320T3 (es) | 1991-10-30 | 2000-04-16 | Astra Ab | Derivados de 2-pirazinil-etilamina y su uso como productos farmaceuticos. |
| NZ251384A (en) * | 1992-04-03 | 1996-10-28 | Fisons Corp | (s)-enantiomer of 1-phenyl-2-(2-pyridinyl) ethylamine and medicaments |
| DK0898566T3 (da) * | 1996-04-19 | 2003-03-03 | Akzo Nobel Nv | Substituerede benzylaminer og anvendelse deraf til behandling af depression |
| ATE229004T1 (de) | 1997-03-31 | 2002-12-15 | Korea Res Inst Chem Tech | Chinolinische sulfid-derivate als nmda rezeptor- antagonisten und verfahren zu ihrer herstellung |
| TW544448B (en) | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| SE9901077D0 (sv) * | 1999-03-23 | 1999-03-23 | Astra Ab | Novel use |
| SE9901340D0 (sv) | 1999-04-15 | 1999-04-15 | Astra Pharma Prod | Novel process |
| DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
| KR20110097996A (ko) | 2008-12-24 | 2011-08-31 | 아스트라제네카 아베 | 에탄아민 화합물 및 우울증의 치료를 위한 그의 용도 |
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2011
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- 2011-06-24 HN HN2011001773A patent/HN2011001773A/es unknown
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- 2011-06-24 NI NI201100131A patent/NI201100131A/es unknown
- 2011-06-24 EC EC2011011161A patent/ECSP11011161A/es unknown
- 2011-06-24 CR CR20110365A patent/CR20110365A/es unknown
- 2011-06-24 CL CL2011001590A patent/CL2011001590A1/es unknown
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2013
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