KR20110073494A - 시냅스 소포 순환 검정 및 시스템 - Google Patents

시냅스 소포 순환 검정 및 시스템 Download PDF

Info

Publication number
KR20110073494A
KR20110073494A KR1020117007795A KR20117007795A KR20110073494A KR 20110073494 A KR20110073494 A KR 20110073494A KR 1020117007795 A KR1020117007795 A KR 1020117007795A KR 20117007795 A KR20117007795 A KR 20117007795A KR 20110073494 A KR20110073494 A KR 20110073494A
Authority
KR
South Korea
Prior art keywords
platform
synaptic vesicle
wells
neuronal cells
range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020117007795A
Other languages
English (en)
Korean (ko)
Inventor
데이비드 제이. 거버
제프리 알. 코트렐
티모시 에이. 리안
조나단 엠. 레벤슨
Original Assignee
갈레네아 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 갈레네아 코포레이션 filed Critical 갈레네아 코포레이션
Publication of KR20110073494A publication Critical patent/KR20110073494A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
KR1020117007795A 2008-09-04 2009-08-31 시냅스 소포 순환 검정 및 시스템 Ceased KR20110073494A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9436108P 2008-09-04 2008-09-04
US61/094,361 2008-09-04

Publications (1)

Publication Number Publication Date
KR20110073494A true KR20110073494A (ko) 2011-06-29

Family

ID=41479300

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117007795A Ceased KR20110073494A (ko) 2008-09-04 2009-08-31 시냅스 소포 순환 검정 및 시스템

Country Status (8)

Country Link
US (2) US20120053084A1 (https=)
EP (1) EP2329275A2 (https=)
JP (2) JP5789513B2 (https=)
KR (1) KR20110073494A (https=)
CN (1) CN102203622A (https=)
AU (2) AU2009288657A1 (https=)
CA (1) CA2744804C (https=)
WO (1) WO2010027446A2 (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100082A1 (en) * 2008-02-04 2009-08-13 Bayer Healthcare Llc Semiconductor based analyte sensors and methods
US9217155B2 (en) 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
US9207237B2 (en) 2010-08-23 2015-12-08 President And Fellows Of Harvard College Systems, methods, and workflows for optogenetics analysis
CA2838330C (en) 2010-08-23 2021-01-26 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
US9488637B2 (en) * 2011-01-26 2016-11-08 The Curators Of The University Of Missouri Combination of single-cell electroporation and electrical recording using the same electrode
EP3318635A1 (en) 2011-04-21 2018-05-09 University of Massachusetts Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
EP2798391A2 (en) * 2011-11-23 2014-11-05 President and Fellows of Harvard College Systems and methods for imaging at high spatial and/or temporal precision
US9696275B2 (en) 2012-10-12 2017-07-04 The Curators Of The University Of Missouri Addressable electrode arrays in multiple fluidic compartments and uses thereof
WO2014065329A1 (ja) * 2012-10-25 2014-05-01 浜松ホトニクス株式会社 細胞観察装置及び細胞観察方法
WO2014065330A1 (ja) 2012-10-25 2014-05-01 浜松ホトニクス株式会社 細胞観察装置、電気刺激装置、及び細胞観察方法
JP6370544B2 (ja) * 2013-11-11 2018-08-08 浜松ホトニクス株式会社 細胞観察装置及び細胞観察方法
WO2015107761A1 (ja) * 2014-01-16 2015-07-23 浜松ホトニクス株式会社 細胞観察装置、電気刺激装置、及び細胞観察方法
US10072251B2 (en) 2014-02-19 2018-09-11 University Of Massachusetts Recombinant AAVS having useful transcytosis properties
CA2942515C (en) 2014-03-18 2025-12-09 University Of Massachusetts Raav-based compositions and methods for treating amyotrophic lateral sclerosis
EP3134729A1 (en) 2014-04-22 2017-03-01 Q-State Biosciences, Inc. Analysis of compounds for pain and sensory disorders
WO2015164786A1 (en) 2014-04-25 2015-10-29 University Of Massachusetts Recombinant aav vectors useful for reducing immunity against transgene products
WO2015195769A2 (en) 2014-06-18 2015-12-23 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
US10625234B2 (en) 2014-08-28 2020-04-21 StemoniX Inc. Method of fabricating cell arrays and uses thereof
US10370432B2 (en) 2014-10-03 2019-08-06 University Of Massachusetts Heterologous targeting peptide grafted AAVS
EP3200830B1 (en) 2014-10-03 2020-09-09 University of Massachusetts High efficiency library-identified aav vectors
CN107073051B (zh) 2014-10-21 2021-08-24 马萨诸塞大学 重组aav变体及其用途
WO2016115333A1 (en) 2015-01-15 2016-07-21 President And Fellows Of Harvard College Optical selection of cells
EP3256170B1 (en) 2015-02-13 2020-09-23 University of Massachusetts Compositions and methods for transient delivery of nucleases
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
EP3285788B1 (en) 2015-04-23 2024-12-18 University of Massachusetts Modulation of aav vector transgene expression
US11046955B2 (en) 2015-04-24 2021-06-29 University Of Massachusetts Modified AAV constructs and uses thereof
US11248212B2 (en) 2015-06-30 2022-02-15 StemoniX Inc. Surface energy directed cell self assembly
US10760053B2 (en) 2015-10-15 2020-09-01 StemoniX Inc. Method of manufacturing or differentiating mammalian pluripotent stem cells or progenitor cells using a hollow fiber bioreactor
EP3364997B1 (en) 2015-10-22 2024-01-17 University of Massachusetts Aspartoacylase gene therapy in the treatment of canavan disease
WO2017070516A1 (en) 2015-10-22 2017-04-27 University Of Massachusetts Prostate-targeting adeno-associated virus serotype vectors
CA3011939A1 (en) 2016-02-02 2017-08-10 University Of Massachusetts Method to enhance the efficiency of systemic aav gene delivery to the central nervous system
CA3012344A1 (en) 2016-02-12 2017-08-17 University Of Massachusetts Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
EP3225279B1 (en) * 2016-03-31 2023-12-20 Université de Rennes Brain tissue stimulation apparatus and computer program
US11207426B2 (en) 2016-04-05 2021-12-28 University Of Massachusetts Compositions and methods for selective inhibition of grainyhead-like protein expression
US11413356B2 (en) 2016-04-15 2022-08-16 University Of Massachusetts Methods and compositions for treating metabolic imbalance
US11882815B2 (en) 2016-06-15 2024-01-30 University Of Massachusetts Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
US10457940B2 (en) 2016-09-22 2019-10-29 University Of Massachusetts AAV treatment of Huntington's disease
AU2017341849B2 (en) 2016-10-13 2024-03-21 University Of Massachusetts AAV capsid designs
US11859179B2 (en) 2017-05-09 2024-01-02 University Of Massachusetts Methods of treating amyotrophic lateral sclerosis (ALS)
CN111448321A (zh) 2017-09-22 2020-07-24 马萨诸塞大学 Sod1双表达载体及其用途
CN112203697A (zh) 2018-04-13 2021-01-08 马萨诸塞大学 编码氨基己糖苷酶alpha和beta亚基的双顺反子AAV载体及其用途
JP7065433B2 (ja) * 2018-08-14 2022-05-12 日本電信電話株式会社 電極及びその製造方法、並びに積層体
US12448629B2 (en) 2018-10-05 2025-10-21 University Of Massachusetts rAAV vectors for the treatment of GM1 and GM2 gangliosidosis
IL325928A (en) * 2019-07-16 2026-03-01 Meso Scale Technologies Llc Testing instruments, methods and reagents
EP4271982A4 (en) * 2020-12-31 2024-11-27 Q-State Biosciences, Inc. Optical plate controller and reader
EP4271978B1 (en) 2020-12-31 2026-05-06 Quiver Holdings Inc. Microscope with spatial imaging and beam homogenizer
JP2024501848A (ja) 2020-12-31 2024-01-16 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 光遺伝学のためのイメージャの較正および正規化
EP4271789A4 (en) * 2020-12-31 2024-11-27 Q-State Biosciences, Inc. PLATE IMAGE PRODUCER
US20220357313A1 (en) * 2021-05-04 2022-11-10 Q-State Biosciences, Inc. Drug fingerprinting
EP4363832A4 (en) 2021-06-30 2025-05-07 Q-State Biosciences, Inc. MULTIPLEX OPTICAL STIMULUS AND READOUT PROCESS
WO2023210585A1 (ja) * 2022-04-25 2023-11-02 株式会社Jiksak Bioengineering 標的化剤
WO2025084395A1 (ja) * 2023-10-19 2025-04-24 株式会社Jiksak Bioengineering 抗シナプトタグミン２抗体
WO2025089346A1 (ja) * 2023-10-25 2025-05-01 株式会社Jiksak Bioengineering 抗シナプトフィジン抗体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000004366A1 (en) * 1998-07-17 2000-01-27 Aurora Biosciences Corporation Detector and screening device for ion channels
US7399599B2 (en) * 2000-07-10 2008-07-15 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
US7615356B2 (en) * 2000-07-10 2009-11-10 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
EP1425065A4 (en) * 2001-07-12 2004-12-15 Merck & Co Inc ELECTRIC FIELD STIMULATION WITH EUKARYONTIC CELLS
US7221981B2 (en) * 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
US20070274923A1 (en) * 2005-01-11 2007-11-29 Philippe Brulet Non-invasive real-time in vivo bioluminescence imaging of local Ca2+ dynamics in living organisms

Also Published As

Publication number Publication date
WO2010027446A4 (en) 2010-08-05
WO2010027446A3 (en) 2010-05-20
JP2016019736A (ja) 2016-02-04
JP6106225B2 (ja) 2017-03-29
US20180136198A1 (en) 2018-05-17
WO2010027446A2 (en) 2010-03-11
CA2744804C (en) 2019-02-05
AU2016202387A1 (en) 2016-05-05
CA2744804A1 (en) 2010-03-11
EP2329275A2 (en) 2011-06-08
JP2012501646A (ja) 2012-01-26
US20120053084A1 (en) 2012-03-01
AU2009288657A1 (en) 2010-03-11
JP5789513B2 (ja) 2015-10-07
CN102203622A (zh) 2011-09-28

Similar Documents

Publication Publication Date Title
KR20110073494A (ko) 시냅스 소포 순환 검정 및 시스템
Liu et al. Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy
Dong et al. Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Newman et al. Input-specific plasticity and homeostasis at the Drosophila larval neuromuscular junction
Hirbec et al. Emerging technologies to study glial cells
JP5645816B2 (ja) 中枢神経細胞の増殖及び分化に係る中核因子を含む医薬組成物
Razy-Krajka et al. Monoaminergic modulation of photoreception in ascidian: evidence for a proto-hypothalamo-retinal territory
Zapata et al. Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission
JP2013240352A (ja) 発光タンパクによる長期モニタリング方法および解析方法
US20060063202A1 (en) High throughput method and system for screening candidate compounds for activity against epilepsy and other neurological diseases
Tian et al. Unlocking opioid neuropeptide dynamics with genetically-encoded biosensors
US20210161383A1 (en) Chromatic bioluminescence as a cellular level readout system of neural activity
Mikati et al. Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice
Mikati et al. Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress
WO2023122254A2 (en) Methods to elicit desire to mate and mating behavior
MX2012003773A (es) Genes. metodos y composiciones relacionadas con la neurogenesis y su modulacion.
Shindo et al. Genetically encoded sensors for analysing neurotransmission among synaptically-connected neurons
HK1162671A (en) Synaptic vesicle cycling assays and systems
US20210246185A1 (en) Inverted transporter polypeptides and methods of using
Blockus et al. Synaptogenic activity of the axon guidance molecule Robo2 is critical for hippocampal circuit function
Aly Autophagy in motion: neuronal activity and behavior guide long-distance autophagic vesicle transport in Locus coeruleus axons projecting to the prefrontal cortex
Karki et al. Evolutionarily conserved role of serotonin signaling in regulating actomyosin contractility during morphogenesis
WO2025154823A1 (ja) 筋細胞の収縮におけるエネルギー効率を測定する方法
Krämer Characterization of CNP-induced cGMP signaling in the gastrointestinal tract and its role in colonic smooth muscle relaxation
Cho Optical imaging of dopamine dynamics and decoding its role in arousal and salience

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20110404

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
AMND Amendment
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20140829

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20151014

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20160521

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20151014

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

X091 Application refused [patent]
AMND Amendment
PX0901 Re-examination

Patent event code: PX09011S01I

Patent event date: 20160521

Comment text: Decision to Refuse Application

Patent event code: PX09012R01I

Patent event date: 20140829

Comment text: Amendment to Specification, etc.

PX0601 Decision of rejection after re-examination

Comment text: Decision to Refuse Application

Patent event code: PX06014S01D

Patent event date: 20160913

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20160822

Comment text: Decision to Refuse Application

Patent event code: PX06011S01I

Patent event date: 20160521

Comment text: Notification of reason for refusal

Patent event code: PX06013S01I

Patent event date: 20151014

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20140829

X601 Decision of rejection after re-examination