AU2009288657A1 - Synaptic vesicle cycling assays and systems - Google Patents
Synaptic vesicle cycling assays and systems Download PDFInfo
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- AU2009288657A1 AU2009288657A1 AU2009288657A AU2009288657A AU2009288657A1 AU 2009288657 A1 AU2009288657 A1 AU 2009288657A1 AU 2009288657 A AU2009288657 A AU 2009288657A AU 2009288657 A AU2009288657 A AU 2009288657A AU 2009288657 A1 AU2009288657 A1 AU 2009288657A1
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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| WO2009100082A1 (en) * | 2008-02-04 | 2009-08-13 | Bayer Healthcare Llc | Semiconductor based analyte sensors and methods |
| US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| US9207237B2 (en) | 2010-08-23 | 2015-12-08 | President And Fellows Of Harvard College | Systems, methods, and workflows for optogenetics analysis |
| CA2838330C (en) | 2010-08-23 | 2021-01-26 | President And Fellows Of Harvard College | Optogenetic probes for measuring membrane potential |
| US9488637B2 (en) * | 2011-01-26 | 2016-11-08 | The Curators Of The University Of Missouri | Combination of single-cell electroporation and electrical recording using the same electrode |
| EP3318635A1 (en) | 2011-04-21 | 2018-05-09 | University of Massachusetts | Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies |
| EP2798391A2 (en) * | 2011-11-23 | 2014-11-05 | President and Fellows of Harvard College | Systems and methods for imaging at high spatial and/or temporal precision |
| US9696275B2 (en) | 2012-10-12 | 2017-07-04 | The Curators Of The University Of Missouri | Addressable electrode arrays in multiple fluidic compartments and uses thereof |
| WO2014065329A1 (ja) * | 2012-10-25 | 2014-05-01 | 浜松ホトニクス株式会社 | 細胞観察装置及び細胞観察方法 |
| WO2014065330A1 (ja) | 2012-10-25 | 2014-05-01 | 浜松ホトニクス株式会社 | 細胞観察装置、電気刺激装置、及び細胞観察方法 |
| JP6370544B2 (ja) * | 2013-11-11 | 2018-08-08 | 浜松ホトニクス株式会社 | 細胞観察装置及び細胞観察方法 |
| WO2015107761A1 (ja) * | 2014-01-16 | 2015-07-23 | 浜松ホトニクス株式会社 | 細胞観察装置、電気刺激装置、及び細胞観察方法 |
| US10072251B2 (en) | 2014-02-19 | 2018-09-11 | University Of Massachusetts | Recombinant AAVS having useful transcytosis properties |
| CA2942515C (en) | 2014-03-18 | 2025-12-09 | University Of Massachusetts | Raav-based compositions and methods for treating amyotrophic lateral sclerosis |
| EP3134729A1 (en) | 2014-04-22 | 2017-03-01 | Q-State Biosciences, Inc. | Analysis of compounds for pain and sensory disorders |
| WO2015164786A1 (en) | 2014-04-25 | 2015-10-29 | University Of Massachusetts | Recombinant aav vectors useful for reducing immunity against transgene products |
| WO2015195769A2 (en) | 2014-06-18 | 2015-12-23 | President And Fellows Of Harvard College | Optogenetic probes for measuring membrane potential |
| US10625234B2 (en) | 2014-08-28 | 2020-04-21 | StemoniX Inc. | Method of fabricating cell arrays and uses thereof |
| US10370432B2 (en) | 2014-10-03 | 2019-08-06 | University Of Massachusetts | Heterologous targeting peptide grafted AAVS |
| EP3200830B1 (en) | 2014-10-03 | 2020-09-09 | University of Massachusetts | High efficiency library-identified aav vectors |
| CN107073051B (zh) | 2014-10-21 | 2021-08-24 | 马萨诸塞大学 | 重组aav变体及其用途 |
| WO2016115333A1 (en) | 2015-01-15 | 2016-07-21 | President And Fellows Of Harvard College | Optical selection of cells |
| EP3256170B1 (en) | 2015-02-13 | 2020-09-23 | University of Massachusetts | Compositions and methods for transient delivery of nucleases |
| US10048275B2 (en) | 2015-03-13 | 2018-08-14 | Q-State Biosciences, Inc. | Cardiotoxicity screening methods |
| EP3285788B1 (en) | 2015-04-23 | 2024-12-18 | University of Massachusetts | Modulation of aav vector transgene expression |
| US11046955B2 (en) | 2015-04-24 | 2021-06-29 | University Of Massachusetts | Modified AAV constructs and uses thereof |
| US11248212B2 (en) | 2015-06-30 | 2022-02-15 | StemoniX Inc. | Surface energy directed cell self assembly |
| US10760053B2 (en) | 2015-10-15 | 2020-09-01 | StemoniX Inc. | Method of manufacturing or differentiating mammalian pluripotent stem cells or progenitor cells using a hollow fiber bioreactor |
| EP3364997B1 (en) | 2015-10-22 | 2024-01-17 | University of Massachusetts | Aspartoacylase gene therapy in the treatment of canavan disease |
| WO2017070516A1 (en) | 2015-10-22 | 2017-04-27 | University Of Massachusetts | Prostate-targeting adeno-associated virus serotype vectors |
| CA3011939A1 (en) | 2016-02-02 | 2017-08-10 | University Of Massachusetts | Method to enhance the efficiency of systemic aav gene delivery to the central nervous system |
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| EP3225279B1 (en) * | 2016-03-31 | 2023-12-20 | Université de Rennes | Brain tissue stimulation apparatus and computer program |
| US11207426B2 (en) | 2016-04-05 | 2021-12-28 | University Of Massachusetts | Compositions and methods for selective inhibition of grainyhead-like protein expression |
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| US10457940B2 (en) | 2016-09-22 | 2019-10-29 | University Of Massachusetts | AAV treatment of Huntington's disease |
| AU2017341849B2 (en) | 2016-10-13 | 2024-03-21 | University Of Massachusetts | AAV capsid designs |
| US11859179B2 (en) | 2017-05-09 | 2024-01-02 | University Of Massachusetts | Methods of treating amyotrophic lateral sclerosis (ALS) |
| CN111448321A (zh) | 2017-09-22 | 2020-07-24 | 马萨诸塞大学 | Sod1双表达载体及其用途 |
| CN112203697A (zh) | 2018-04-13 | 2021-01-08 | 马萨诸塞大学 | 编码氨基己糖苷酶alpha和beta亚基的双顺反子AAV载体及其用途 |
| JP7065433B2 (ja) * | 2018-08-14 | 2022-05-12 | 日本電信電話株式会社 | 電極及びその製造方法、並びに積層体 |
| US12448629B2 (en) | 2018-10-05 | 2025-10-21 | University Of Massachusetts | rAAV vectors for the treatment of GM1 and GM2 gangliosidosis |
| IL325928A (en) * | 2019-07-16 | 2026-03-01 | Meso Scale Technologies Llc | Testing instruments, methods and reagents |
| EP4271982A4 (en) * | 2020-12-31 | 2024-11-27 | Q-State Biosciences, Inc. | Optical plate controller and reader |
| EP4271978B1 (en) | 2020-12-31 | 2026-05-06 | Quiver Holdings Inc. | Microscope with spatial imaging and beam homogenizer |
| JP2024501848A (ja) | 2020-12-31 | 2024-01-16 | キュー－ステート バイオサイエンシーズ， インコーポレイテッド | 光遺伝学のためのイメージャの較正および正規化 |
| EP4271789A4 (en) * | 2020-12-31 | 2024-11-27 | Q-State Biosciences, Inc. | PLATE IMAGE PRODUCER |
| US20220357313A1 (en) * | 2021-05-04 | 2022-11-10 | Q-State Biosciences, Inc. | Drug fingerprinting |
| EP4363832A4 (en) | 2021-06-30 | 2025-05-07 | Q-State Biosciences, Inc. | MULTIPLEX OPTICAL STIMULUS AND READOUT PROCESS |
| WO2023210585A1 (ja) * | 2022-04-25 | 2023-11-02 | 株式会社Jiksak Bioengineering | 標的化剤 |
| WO2025084395A1 (ja) * | 2023-10-19 | 2025-04-24 | 株式会社Jiksak Bioengineering | 抗シナプトタグミン２抗体 |
| WO2025089346A1 (ja) * | 2023-10-25 | 2025-05-01 | 株式会社Jiksak Bioengineering | 抗シナプトフィジン抗体 |
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| WO2000004366A1 (en) * | 1998-07-17 | 2000-01-27 | Aurora Biosciences Corporation | Detector and screening device for ion channels |
| US7399599B2 (en) * | 2000-07-10 | 2008-07-15 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| US7615356B2 (en) * | 2000-07-10 | 2009-11-10 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| EP1425065A4 (en) * | 2001-07-12 | 2004-12-15 | Merck & Co Inc | ELECTRIC FIELD STIMULATION WITH EUKARYONTIC CELLS |
| US7221981B2 (en) * | 2002-03-28 | 2007-05-22 | Northstar Neuroscience, Inc. | Electrode geometries for efficient neural stimulation |
| US20070274923A1 (en) * | 2005-01-11 | 2007-11-29 | Philippe Brulet | Non-invasive real-time in vivo bioluminescence imaging of local Ca2+ dynamics in living organisms |
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| AU2016202387A1 (en) | 2016-05-05 |
| CA2744804A1 (en) | 2010-03-11 |
| EP2329275A2 (en) | 2011-06-08 |
| KR20110073494A (ko) | 2011-06-29 |
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| US20120053084A1 (en) | 2012-03-01 |
| JP5789513B2 (ja) | 2015-10-07 |
| CN102203622A (zh) | 2011-09-28 |
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