KR20100107475A - 부작용을 감소 또는 예방하기 위한 클로스트리디움 보툴리눔 독소 복합체의 신경독성 성분의 용도 - Google Patents

부작용을 감소 또는 예방하기 위한 클로스트리디움 보툴리눔 독소 복합체의 신경독성 성분의 용도 Download PDF

Info

Publication number
KR20100107475A
KR20100107475A KR1020107016383A KR20107016383A KR20100107475A KR 20100107475 A KR20100107475 A KR 20100107475A KR 1020107016383 A KR1020107016383 A KR 1020107016383A KR 20107016383 A KR20107016383 A KR 20107016383A KR 20100107475 A KR20100107475 A KR 20100107475A
Authority
KR
South Korea
Prior art keywords
neurotoxic component
muscle
muscles
facial
botulinum toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020107016383A
Other languages
English (en)
Korean (ko)
Inventor
에리히 하우놀트
마티아스 마르크스
Original Assignee
메르츠 파마 게엠베하 운트 코. 카가아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 메르츠 파마 게엠베하 운트 코. 카가아 filed Critical 메르츠 파마 게엠베하 운트 코. 카가아
Publication of KR20100107475A publication Critical patent/KR20100107475A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893Botulinum neurotoxin (3.4.24.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Neurosurgery (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
KR1020107016383A 2007-12-21 2008-12-17 부작용을 감소 또는 예방하기 위한 클로스트리디움 보툴리눔 독소 복합체의 신경독성 성분의 용도 Withdrawn KR20100107475A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US901007P 2007-12-21 2007-12-21
EP07024961A EP2072039A1 (en) 2007-12-21 2007-12-21 Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects
EP07024961.0 2007-12-21
US61/009,010 2007-12-21

Publications (1)

Publication Number Publication Date
KR20100107475A true KR20100107475A (ko) 2010-10-05

Family

ID=39401018

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107016383A Withdrawn KR20100107475A (ko) 2007-12-21 2008-12-17 부작용을 감소 또는 예방하기 위한 클로스트리디움 보툴리눔 독소 복합체의 신경독성 성분의 용도

Country Status (13)

Country Link
US (1) US20100331259A1 (enExample)
EP (2) EP2072039A1 (enExample)
JP (1) JP2011506511A (enExample)
KR (1) KR20100107475A (enExample)
CN (1) CN101917960A (enExample)
AR (1) AR069806A1 (enExample)
AU (1) AU2008340713A1 (enExample)
CA (1) CA2709644A1 (enExample)
IL (1) IL206423A0 (enExample)
MX (1) MX2010006731A (enExample)
RU (1) RU2010130542A (enExample)
WO (1) WO2009080272A1 (enExample)
ZA (1) ZA201004393B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023282573A1 (ko) 2021-07-05 2023-01-12 주식회사 파마리서치바이오 클로스트리디움 보툴리눔 독소 복합체 단백질의 정제방법
WO2023282653A1 (ko) 2021-07-08 2023-01-12 주식회사 파마리서치바이오 비-독소 단백질이 제거된 클로스트리디움 보툴리눔 신경독소 단백질의 정제방법
WO2024091049A1 (ko) 2022-10-28 2024-05-02 주식회사 파마리서치바이오 보툴리눔 독소를 포함하는 안정한 액상 제제

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10792344B2 (en) * 2006-06-29 2020-10-06 Merz Pharma Gmbh & Co. Kgaa High frequency application of botulinum toxin therapy
US9161970B2 (en) * 2007-12-12 2015-10-20 Allergan, Inc. Dermal filler
US9480731B2 (en) * 2013-12-12 2016-11-01 Medy-Tox, Inc. Long lasting effect of new botulinum toxin formulations
US11484580B2 (en) 2014-07-18 2022-11-01 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US9901627B2 (en) 2014-07-18 2018-02-27 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
WO2018146550A1 (en) * 2017-02-10 2018-08-16 De Maio Domingos Mauricio Methods and systems for preventing, correcting, transforming, and modifying facial, aesthetics, and consulting patients regarding the same
DE102019215585B4 (de) * 2019-10-10 2022-02-17 KCM Egészségügyi és Tudományos Korlátolt Felelösségü Társaság Verfahren zur prävention von strahlenschäden in humanen drüsen
US11241479B2 (en) 2019-10-18 2022-02-08 Penland Foundation Treatment methods using botulinum toxins
US10973873B1 (en) 2019-10-18 2021-04-13 Penland Foundation Treatment of asthma using botulinum toxin
US11090371B1 (en) * 2019-10-18 2021-08-17 Penland Foundation Treatment of cirrhosis using botulinum toxin
US11925677B2 (en) 2021-07-12 2024-03-12 Penland Foundation Treatment of diabetes and chronic pancreatitis using botulinum toxin
US10967052B1 (en) 2019-10-18 2021-04-06 Penland Foundation Treatment of dyslexia using botulinum toxin
AU2020365148B2 (en) 2019-10-18 2022-10-27 Penland Foundation Botulinum toxin for use in treatment
US11738071B2 (en) 2021-07-12 2023-08-29 Penland Foundation Treatment of acute and chronic kidney disease
US10987411B1 (en) 2019-10-18 2021-04-27 Penland Foundation Treatment of chronic obstructive pulmonary disease using botulinum toxin
US10960061B1 (en) * 2019-10-18 2021-03-30 Penland Foundation Treatment of amyotrophic lateral sclerosis using botulinum toxin
US10960060B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of cardiac arrhythmia using botulinum toxin
KR102397708B1 (ko) * 2020-04-29 2022-05-16 한국화학연구원 탄닌산을 포함하는 보툴리눔 독소 약제학적 조성물
CN116096399A (zh) * 2020-06-03 2023-05-09 米奥托克斯有限责任公司 用于治疗偏头痛病症的区带性和靶向方法和用途
IL298399A (en) * 2020-06-05 2023-01-01 Merz Pharma Gmbh & Co Kgaa Treatment of facial wrinkles with the botulinum toxin in high dose and low volume

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8187612B2 (en) * 1993-12-28 2012-05-29 Allergan, Inc. Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle
EP1602379A1 (en) * 1993-12-28 2005-12-07 Allergan, Inc. Botulinum toxin B for treating spastic muscle
US5512547A (en) * 1994-10-13 1996-04-30 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation
US5756468A (en) * 1994-10-13 1998-05-26 Wisconsin Alumni Research Foundation Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation
DE19925739A1 (de) * 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutikum mit einem Botulinum-Neurotoxin
CA2494241C (en) 2000-02-08 2011-06-14 Allergan, Inc. Botulinum toxin pharmaceutical compositions
US6503653B2 (en) * 2001-02-23 2003-01-07 General Motors Corporation Stamped bipolar plate for PEM fuel cell stack
JP3830766B2 (ja) * 2001-03-09 2006-10-11 本田技研工業株式会社 燃料電池および燃料電池スタック
EP1491205A4 (en) * 2002-03-29 2007-04-25 Chemo Sero Therapeut Res Inst MEANS FOR THE TREATMENT OF HYPERMYOTONIA
US20040115222A1 (en) * 2002-09-06 2004-06-17 Michael Kane Method for reduction of wrinkles
JP2005089336A (ja) * 2003-09-12 2005-04-07 Tokyo Univ Of Agriculture D型ボツリヌス神経毒素の精製法
BRPI0513850A (pt) * 2004-07-26 2008-05-20 Merz Pharma Gmbh & Co Kgaa composição terapêutica com uma neurotoxina botulìnica
GB2426702A (en) * 2004-10-28 2006-12-06 Ipsen Ltd Pharmaceutical composition comprising botulinum neurotoxin
DE102004043009A1 (de) * 2004-09-06 2006-03-23 Toxogen Gmbh Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen
DE102005019302A1 (de) 2005-04-26 2006-11-16 Toxogen Gmbh Carrier zum Targeting von Nervenzellen
AR061669A1 (es) 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa Aplicacion de alta frecuencia de terapia con toxina botulinica

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023282573A1 (ko) 2021-07-05 2023-01-12 주식회사 파마리서치바이오 클로스트리디움 보툴리눔 독소 복합체 단백질의 정제방법
WO2023282653A1 (ko) 2021-07-08 2023-01-12 주식회사 파마리서치바이오 비-독소 단백질이 제거된 클로스트리디움 보툴리눔 신경독소 단백질의 정제방법
WO2024091049A1 (ko) 2022-10-28 2024-05-02 주식회사 파마리서치바이오 보툴리눔 독소를 포함하는 안정한 액상 제제

Also Published As

Publication number Publication date
MX2010006731A (es) 2010-08-16
AR069806A1 (es) 2010-02-17
IL206423A0 (en) 2010-12-30
CN101917960A (zh) 2010-12-15
CA2709644A1 (en) 2009-07-02
AU2008340713A1 (en) 2009-07-02
EP2231107A1 (en) 2010-09-29
EP2072039A1 (en) 2009-06-24
RU2010130542A (ru) 2012-01-27
ZA201004393B (en) 2011-08-31
WO2009080272A1 (en) 2009-07-02
US20100331259A1 (en) 2010-12-30
JP2011506511A (ja) 2011-03-03

Similar Documents

Publication Publication Date Title
KR20100107475A (ko) 부작용을 감소 또는 예방하기 위한 클로스트리디움 보툴리눔 독소 복합체의 신경독성 성분의 용도
TWI519310B (zh) 肉毒梭菌毒素治療之高頻率施用
DE69902396T3 (de) Stabilisierte flüssige arzneizubereitungen enthaltend botulinum toxin
KR101095725B1 (ko) 신경학적 및 신경정신학적 장애의 보툴리눔 독소 처치
JP7053498B2 (ja) トリプトファンまたはチロシンで安定化された液体神経毒素製剤
RU2743746C2 (ru) Композиция, содержащая ботулинический токсин
JPH06510779A (ja) 脳性麻痺を処置するための方法および組成物
JP2010514781A (ja) Hiv−tatに由来するポリペプチド断片を用いて安定化されるボツリヌス毒素を局所適用及び経皮送達する組成物及び方法
US12440543B2 (en) Botulinum toxin type a complex, and formulation thereof and usage method therefor
WO2011160826A1 (en) Botulinum toxin therapy
US20220395561A1 (en) Neurotoxins for use in minimizing scarring
ES2401570T3 (es) Composiciones farmacéuticas que contienen 3,4-propinoperhidropurinas y usos de las mismas para bloquear la transmisión neuronal
KR101824450B1 (ko) 히알루로니다제를 포함한 지방분해 및 보톡스 기능이 강화된 약물 키트
ES2665285T3 (es) Tratamiento temprano y prevención del aumento de la tonicidad muscular
HK1151217A (en) Use of a neurotoxic component of a clostridium botulinum toxin complex to reduce or prevent side effects
TWI739368B (zh) A型肉毒桿菌毒素複合物、其配製劑和使用方法
WO2002059289A1 (de) Verwendung von mikrobieller hyaluronatlyase zur bindegewebserweichung
EA048438B1 (ru) Применение фармацевтической композиции для лечения заболеваний и/или патологий тканей
HK1131739A (en) High frequency application of neurotoxic component of botulinum toxin

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20100721

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid