KR20100102092A - 아자시티딘 유사체 및 이들의 용도 - Google Patents

아자시티딘 유사체 및 이들의 용도 Download PDF

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Publication number
KR20100102092A
KR20100102092A KR1020107008902A KR20107008902A KR20100102092A KR 20100102092 A KR20100102092 A KR 20100102092A KR 1020107008902 A KR1020107008902 A KR 1020107008902A KR 20107008902 A KR20107008902 A KR 20107008902A KR 20100102092 A KR20100102092 A KR 20100102092A
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formula
compound
integer
subject
aza
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Korean (ko)
Inventor
루이스 실버만
제임스 홀란드
마리트 릴란드 샌드볼드
핀 미렌
올레 헨릭 에릭슨
Original Assignee
마운트 시나이 스쿨 오브 메디신
클라비스 파마 에이에스에이
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Publication of KR20100102092A publication Critical patent/KR20100102092A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020107008902A 2007-09-26 2008-09-25 아자시티딘 유사체 및 이들의 용도 Withdrawn KR20100102092A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97543707P 2007-09-26 2007-09-26
US60/975,437 2007-09-26

Publications (1)

Publication Number Publication Date
KR20100102092A true KR20100102092A (ko) 2010-09-20

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Family Applications (2)

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KR1020107008902A Withdrawn KR20100102092A (ko) 2007-09-26 2008-09-25 아자시티딘 유사체 및 이들의 용도
KR1020107007252A Withdrawn KR20100072230A (ko) 2007-09-26 2008-09-25 아자시티딘 유사체 및 이의 용도

Family Applications After (1)

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KR1020107007252A Withdrawn KR20100072230A (ko) 2007-09-26 2008-09-25 아자시티딘 유사체 및 이의 용도

Country Status (15)

Country Link
US (2) US8158605B2 (enExample)
EP (2) EP2197274A4 (enExample)
JP (2) JP2010540556A (enExample)
KR (2) KR20100102092A (enExample)
CN (2) CN101815437A (enExample)
AU (2) AU2008304380A1 (enExample)
BR (2) BRPI0817269A2 (enExample)
CA (2) CA2700267A1 (enExample)
IL (1) IL204690A0 (enExample)
MX (2) MX2010003002A (enExample)
NZ (2) NZ583923A (enExample)
RU (1) RU2488591C2 (enExample)
UA (2) UA99308C2 (enExample)
WO (2) WO2009042766A1 (enExample)
ZA (1) ZA201001660B (enExample)

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ES2927556T3 (es) 2008-05-15 2022-11-08 Celgene Corp Formulaciones orales de análogos de citidina y métodos de uso de los mismos
WO2010014883A2 (en) * 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
AR076418A1 (es) * 2009-04-27 2011-06-08 Reddys Lab Inc Dr Preparacion de decitabina
JP2014503597A (ja) 2011-01-31 2014-02-13 セルジーン コーポレイション シチジンアナログの医薬組成物及びその使用方法
TW201303295A (zh) * 2011-04-15 2013-01-16 克雷維斯製藥公司 偵測血液失調中之人平衡型核苷轉運蛋白１（ｈＥＮＴ１）表現用之系統和方法
JP6162709B2 (ja) 2011-11-01 2017-07-12 セルジーン コーポレイション シチジンアナログの経口製剤を使用して癌を治療する方法
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CN110996955A (zh) 2017-06-22 2020-04-10 细胞基因公司 以乙型肝炎病毒感染为特征的肝细胞癌的治疗
KR102810546B1 (ko) * 2018-04-19 2025-05-20 써던 리서취 인스티튜트 암의 치료를 위한 4'-티오-뉴클레오타이드 및 -뉴클레오사이드 전구약물
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NZ583923A (en) 2012-05-25
CA2700207A1 (en) 2009-04-02
AU2008304380A1 (en) 2009-04-02
MX2010003002A (es) 2010-07-05
AU2008304381A1 (en) 2009-04-02
JP2010540556A (ja) 2010-12-24
WO2009042766A9 (en) 2009-05-28
CA2700267A1 (en) 2009-04-02
US8399420B2 (en) 2013-03-19
EP2205073A4 (en) 2013-03-06
BRPI0817269A2 (pt) 2014-10-07
JP2010540555A (ja) 2010-12-24
RU2488591C2 (ru) 2013-07-27
UA99836C2 (en) 2012-10-10
CN101815437A (zh) 2010-08-25
NZ583824A (en) 2012-06-29
BRPI0817234A2 (pt) 2014-09-30
US20090209482A1 (en) 2009-08-20
WO2009042767A1 (en) 2009-04-02
MX2010003261A (es) 2010-08-18
WO2009042766A1 (en) 2009-04-02
CN101877964A (zh) 2010-11-03
UA99308C2 (ru) 2012-08-10
RU2010116154A (ru) 2011-11-10
RU2010116274A (ru) 2011-11-10
US8158605B2 (en) 2012-04-17
EP2205073A1 (en) 2010-07-14
EP2197274A4 (en) 2013-03-06
US20090209477A1 (en) 2009-08-20
EP2197274A1 (en) 2010-06-23
IL204690A0 (en) 2010-11-30
ZA201001660B (en) 2011-05-25
KR20100072230A (ko) 2010-06-30

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