KR20100049698A - 바이사이클 피리미디논 및 그 용도 - Google Patents

바이사이클 피리미디논 및 그 용도 Download PDF

Info

Publication number
KR20100049698A
KR20100049698A KR1020107008711A KR20107008711A KR20100049698A KR 20100049698 A KR20100049698 A KR 20100049698A KR 1020107008711 A KR1020107008711 A KR 1020107008711A KR 20107008711 A KR20107008711 A KR 20107008711A KR 20100049698 A KR20100049698 A KR 20100049698A
Authority
KR
South Korea
Prior art keywords
alkyl
compound
hydroxy
oxo
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020107008711A
Other languages
English (en)
Korean (ko)
Inventor
에릭 데일 존스
조나단 앨런 빅터 코츠
데이비드 이안 로즈
존 조셉 데드맨
니콜라스 앤드류 밴드그라프
리사 제인 윈필드
니라낫 티엔통
윌리암 이싸
네일 초이
캐서린 맥팔레인
Original Assignee
아벡사 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2006907283A external-priority patent/AU2006907283A0/en
Application filed by 아벡사 리미티드 filed Critical 아벡사 리미티드
Publication of KR20100049698A publication Critical patent/KR20100049698A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020107008711A 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도 Ceased KR20100049698A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
AU2006907283 2006-12-22
AU2006907283A AU2006907283A0 (en) 2006-12-22 Bicyclic pyrimidinones and uses thereof
AU2007902479 2007-05-09
AU2007902479A AU2007902479A0 (en) 2007-05-09 Bicyclic pyrimidinones and uses thereof (2)
AU2007903401 2007-06-25
AU2007903401A AU2007903401A0 (en) 2007-06-25 Bicyclic pyrimidinodes and uses thereof (3)
AU2007904114 2007-07-31
AU2007904114A AU2007904114A0 (en) 2007-07-31 Bicyclic pyrimidinones and uses thereof (4)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020097014886A Division KR20090097194A (ko) 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도

Publications (1)

Publication Number Publication Date
KR20100049698A true KR20100049698A (ko) 2010-05-12

Family

ID=39562030

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020097014886A Ceased KR20090097194A (ko) 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도
KR1020107008711A Ceased KR20100049698A (ko) 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020097014886A Ceased KR20090097194A (ko) 2006-12-22 2007-12-21 바이사이클 피리미디논 및 그 용도

Country Status (15)

Country Link
US (3) US8143268B2 (enExample)
EP (2) EP2114903B1 (enExample)
JP (2) JP5208962B2 (enExample)
KR (2) KR20090097194A (enExample)
CN (1) CN101880280B (enExample)
AR (2) AR064517A1 (enExample)
AT (1) ATE496898T1 (enExample)
AU (2) AU2007336703B9 (enExample)
BR (2) BRPI0720564A2 (enExample)
CA (1) CA2673183C (enExample)
DE (1) DE602007012308D1 (enExample)
DK (1) DK2114903T3 (enExample)
MX (1) MX2009006764A (enExample)
NZ (1) NZ577491A (enExample)
WO (1) WO2008077188A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2247601T3 (pl) * 2008-07-02 2013-09-30 Avexa Ltd Tiazopirymidynony i ich zastosowanie
JP5592360B2 (ja) * 2008-07-02 2014-09-17 アベキサ・リミテッド イミダゾピリミジノンおよびその使用
BRPI0913934A2 (pt) * 2008-07-02 2015-10-20 Avexa Ltd compostos tendo propriedades antivirais
CN102336751A (zh) * 2010-07-16 2012-02-01 爱维艾珂瑟有限公司 新型抗病毒剂
JP6448647B2 (ja) 2013-09-12 2019-01-09 アリオス バイオファーマ インク． アザ−ピリドン化合物およびその用途
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
MX383931B (es) 2015-03-11 2025-03-14 Janssen Biopharma Inc Compuestos de aza-piridona y usos de estos.
EP3310169B1 (en) 2015-05-30 2023-05-17 PTC Therapeutics, Inc. Methods for modulating rna splicing
CN108697709A (zh) 2015-12-10 2018-10-23 Ptc医疗公司 用于治疗亨廷顿病的方法
AU2017363369A1 (en) 2016-11-28 2019-05-30 Ptc Therapeutics, Inc Methods for modulating RNA splicing
AU2018282154B2 (en) 2017-06-05 2022-04-07 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
US11608501B2 (en) 2017-06-14 2023-03-21 Ptc Therapeutics, Inc. Methods for modifying RNA splicing
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
WO2019005993A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
BR112020019373A2 (pt) 2018-03-27 2020-12-29 Ptc Therapeutics, Inc. Compostos para o tratamento da doença de hutington
IL279688B2 (en) 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
EP3814360B8 (en) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
WO2020005877A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
AU2020394867A1 (en) 2019-12-02 2022-05-26 Storm Therapeutics Limited Polyheterocyclic compounds as METTL3 inhibitors
US12070445B2 (en) * 2021-08-27 2024-08-27 Wisconsin Alumni Research Foundation System and assay for monitoring production/release of membrane-lytic toxins in bacteria and compounds for modulating same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002241459A1 (en) 2000-09-20 2002-06-11 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
AR042095A1 (es) 2002-11-20 2005-06-08 Japan Tobacco Inc Compuesto 4-oxoquinolina y aplicacion del mismo como inhibidor de integrasa de vih
DK1697343T3 (da) 2003-12-18 2009-10-05 Tibotec Pharm Ltd Aminobenzimidazoler og benzimidazoler som inhibitorer af replikation af respiratorisk syncytialvirus
TW200526635A (en) * 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
AU2005293336B2 (en) 2004-10-12 2009-05-28 Astrazeneca Ab Quinazoline derivatives
CN101146811B (zh) * 2005-03-31 2012-01-11 P.安杰莱蒂分子生物学研究所 Hiv整合酶抑制剂
EP1937678B1 (en) * 2005-10-04 2011-07-27 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hiv integrase inhibitors

Also Published As

Publication number Publication date
HK1131615A1 (en) 2010-01-29
AU2007336703B2 (en) 2012-04-12
AR077043A2 (es) 2011-07-27
JP5208962B2 (ja) 2013-06-12
EP2114903A1 (en) 2009-11-11
US8143268B2 (en) 2012-03-27
CA2673183A1 (en) 2008-07-03
AU2010201160A1 (en) 2010-04-15
CN101880280A (zh) 2010-11-10
EP2114903A4 (en) 2009-12-30
CN101880280B (zh) 2014-07-16
AU2007336703A1 (en) 2008-07-03
BRPI0722411A2 (pt) 2012-06-05
AR064517A1 (es) 2009-04-08
ATE496898T1 (de) 2011-02-15
DK2114903T3 (da) 2011-04-18
EP2269992A1 (en) 2011-01-05
JP2010222370A (ja) 2010-10-07
US20100168063A1 (en) 2010-07-01
US20110009366A1 (en) 2011-01-13
BRPI0720564A2 (pt) 2011-08-16
US8207334B2 (en) 2012-06-26
WO2008077188A1 (en) 2008-07-03
MX2009006764A (es) 2009-11-26
US8859563B2 (en) 2014-10-14
DE602007012308D1 (de) 2011-03-10
CA2673183C (en) 2014-06-10
NZ577491A (en) 2011-06-30
EP2114903B1 (en) 2011-01-26
JP2010513322A (ja) 2010-04-30
KR20090097194A (ko) 2009-09-15
US20120232035A1 (en) 2012-09-13
AU2007336703B9 (en) 2014-03-27

Similar Documents

Publication Publication Date Title
JP5208962B2 (ja) 二環式ピリミジノンおよびその使用
JP5535204B2 (ja) 抗ウイルス特性を有する化合物
JP2012514044A (ja) Ｒａｆキナーゼ阻害剤として有用なヘテロアリール化合物
JP2003321472A (ja) Ｇｒｋ阻害剤
BR112020005934A2 (pt) inibidor de pde9 e uso do mesmo
JP7597378B2 (ja) ハロゲン化アリルアミン系化合物及びその適用
CA2729656A1 (en) Imidazopyrimidinones and uses thereof
JP2023548031A (ja) 二環式化合物
WO2009119776A1 (ja) 縮合複素環誘導体およびその用途
CN101627019B (zh) 双环嘧啶酮以及其应用
ES2358550T3 (es) Pirimidinonas bicíclicas y sus usos.
HK1131615B (en) Bicyclic pyrimidinones and uses thereof

Legal Events

Date Code Title Description
A107 Divisional application of patent
A201 Request for examination
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20100421

PA0201 Request for examination
PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20111216

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20120717

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20111216

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I