CN101880280B - 双环嘧啶酮以及其应用 - Google Patents
双环嘧啶酮以及其应用 Download PDFInfo
- Publication number
- CN101880280B CN101880280B CN201010148170.6A CN201010148170A CN101880280B CN 101880280 B CN101880280 B CN 101880280B CN 201010148170 A CN201010148170 A CN 201010148170A CN 101880280 B CN101880280 B CN 101880280B
- Authority
- CN
- China
- Prior art keywords
- hydroxy
- oxo
- pyrimidine
- nmr
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*(CCC1*(C)*(*=O)=C(C2)O)*1C2=O Chemical compound C*(CCC1*(C)*(*=O)=C(C2)O)*1C2=O 0.000 description 5
- MIRPRCLIIOLHOQ-UHFFFAOYSA-N COC(C(N=C1N(C2=O)Oc3c1cccc3)=C2OCc1ccccc1)=O Chemical compound COC(C(N=C1N(C2=O)Oc3c1cccc3)=C2OCc1ccccc1)=O MIRPRCLIIOLHOQ-UHFFFAOYSA-N 0.000 description 2
- UOXSBGLUFFMQLK-UHFFFAOYSA-N C=C1N2Oc(cccc3)c3C2=NC(C(O)=O)=C1OCc1ccccc1 Chemical compound C=C1N2Oc(cccc3)c3C2=NC(C(O)=O)=C1OCc1ccccc1 UOXSBGLUFFMQLK-UHFFFAOYSA-N 0.000 description 1
- CPXYMXNMRWTCPM-UHFFFAOYSA-N CC(C)(C)C(OC1=C(C(OC)=O)N=C2SC=CN2C1=O)=O Chemical compound CC(C)(C)C(OC1=C(C(OC)=O)N=C2SC=CN2C1=O)=O CPXYMXNMRWTCPM-UHFFFAOYSA-N 0.000 description 1
- DTLDFZGZVFNGJO-UHFFFAOYSA-N CC(C)=NOc(cccc1)c1C#N Chemical compound CC(C)=NOc(cccc1)c1C#N DTLDFZGZVFNGJO-UHFFFAOYSA-N 0.000 description 1
- WHZQYQDNCOSKKN-UHFFFAOYSA-N CC(C=CC1=NC(/C(/N)=N/O)=C2OCc3ccccc3)=CN1C2=O Chemical compound CC(C=CC1=NC(/C(/N)=N/O)=C2OCc3ccccc3)=CN1C2=O WHZQYQDNCOSKKN-UHFFFAOYSA-N 0.000 description 1
- OLAIBBZSXYIPOE-UHFFFAOYSA-N CC(C=CC1=NC(C#N)=C2OCc3ccccc3)=CN1C2=O Chemical compound CC(C=CC1=NC(C#N)=C2OCc3ccccc3)=CN1C2=O OLAIBBZSXYIPOE-UHFFFAOYSA-N 0.000 description 1
- OMHNZQHMIZHOQF-UHFFFAOYSA-N CC(C=CC1=NC(c2ncc(-c(cc3)ccc3F)[o]2)=C2O)=CN1C2=O Chemical compound CC(C=CC1=NC(c2ncc(-c(cc3)ccc3F)[o]2)=C2O)=CN1C2=O OMHNZQHMIZHOQF-UHFFFAOYSA-N 0.000 description 1
- TXMPYUZNDGENMG-UHFFFAOYSA-N CC(C=CC1=NC(c2ncc(Cc(cc3)ccc3F)[o]2)=C2O)=CN1C2=O Chemical compound CC(C=CC1=NC(c2ncc(Cc(cc3)ccc3F)[o]2)=C2O)=CN1C2=O TXMPYUZNDGENMG-UHFFFAOYSA-N 0.000 description 1
- SODOBZLBIXDOGR-UHFFFAOYSA-N CC(C=CC1=NC(c2nnc(Cc(cc3Cl)ccc3Cl)[o]2)=C2O)=CN1C2=O Chemical compound CC(C=CC1=NC(c2nnc(Cc(cc3Cl)ccc3Cl)[o]2)=C2O)=CN1C2=O SODOBZLBIXDOGR-UHFFFAOYSA-N 0.000 description 1
- PYLTUGQKXHVVSD-UHFFFAOYSA-N CC(N1C2=O)=CSC1=NC(C(NCc(cc1Cl)ccc1Cl)=O)=C2O Chemical compound CC(N1C2=O)=CSC1=NC(C(NCc(cc1Cl)ccc1Cl)=O)=C2O PYLTUGQKXHVVSD-UHFFFAOYSA-N 0.000 description 1
- QMSVRDBHHMPHCC-UHFFFAOYSA-N CCC(Cc(cc1)ccc1F)O/N=C(/C(N=C(C=CC(C)=C1)N1C1=O)=C1OCc1ccccc1)\N Chemical compound CCC(Cc(cc1)ccc1F)O/N=C(/C(N=C(C=CC(C)=C1)N1C1=O)=C1OCc1ccccc1)\N QMSVRDBHHMPHCC-UHFFFAOYSA-N 0.000 description 1
- QZUIWCRNRQXGNQ-UHFFFAOYSA-N COC(C(N=C(C=CC(N1CCOCC1)=C1)N1C1=O)=C1O)=O Chemical compound COC(C(N=C(C=CC(N1CCOCC1)=C1)N1C1=O)=C1O)=O QZUIWCRNRQXGNQ-UHFFFAOYSA-N 0.000 description 1
- LFMJAMQJGHIXDH-UHFFFAOYSA-N COC(C(N=C1N(C2=O)OC3=C1C=CCC3)=C2O)=O Chemical compound COC(C(N=C1N(C2=O)OC3=C1C=CCC3)=C2O)=O LFMJAMQJGHIXDH-UHFFFAOYSA-N 0.000 description 1
- PMJFXTZQFWUBJW-UHFFFAOYSA-N COC(C(N=C1SC=CN1C1=O)=C1O)=O Chemical compound COC(C(N=C1SC=CN1C1=O)=C1O)=O PMJFXTZQFWUBJW-UHFFFAOYSA-N 0.000 description 1
- KHEJQMGVSOEJPU-UHFFFAOYSA-N CS(N1CCN(CC(SC2=NC(C(NCc(cc3Cl)ccc3Cl)=O)=C3O)=CN2C3=O)CC1)(=O)=O Chemical compound CS(N1CCN(CC(SC2=NC(C(NCc(cc3Cl)ccc3Cl)=O)=C3O)=CN2C3=O)CC1)(=O)=O KHEJQMGVSOEJPU-UHFFFAOYSA-N 0.000 description 1
- RAIPHJJURHTUIC-UHFFFAOYSA-N Nc1ncc[s]1 Chemical compound Nc1ncc[s]1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2006907283 | 2006-12-22 | ||
| AU2006907283A AU2006907283A0 (en) | 2006-12-22 | Bicyclic pyrimidinones and uses thereof | |
| AU2007902479 | 2007-05-09 | ||
| AU2007902479A AU2007902479A0 (en) | 2007-05-09 | Bicyclic pyrimidinones and uses thereof (2) | |
| AU2007903401 | 2007-06-25 | ||
| AU2007903401A AU2007903401A0 (en) | 2007-06-25 | Bicyclic pyrimidinodes and uses thereof (3) | |
| AU2007904114A AU2007904114A0 (en) | 2007-07-31 | Bicyclic pyrimidinones and uses thereof (4) | |
| AU2007904114 | 2007-07-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780051562.7A Division CN101627019B (zh) | 2006-12-22 | 2007-12-21 | 双环嘧啶酮以及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101880280A CN101880280A (zh) | 2010-11-10 |
| CN101880280B true CN101880280B (zh) | 2014-07-16 |
Family
ID=39562030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010148170.6A Expired - Fee Related CN101880280B (zh) | 2006-12-22 | 2007-12-21 | 双环嘧啶酮以及其应用 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8143268B2 (enExample) |
| EP (2) | EP2269992A1 (enExample) |
| JP (2) | JP5208962B2 (enExample) |
| KR (2) | KR20090097194A (enExample) |
| CN (1) | CN101880280B (enExample) |
| AR (2) | AR064517A1 (enExample) |
| AT (1) | ATE496898T1 (enExample) |
| AU (2) | AU2007336703B9 (enExample) |
| BR (2) | BRPI0722411A2 (enExample) |
| CA (1) | CA2673183C (enExample) |
| DE (1) | DE602007012308D1 (enExample) |
| DK (1) | DK2114903T3 (enExample) |
| MX (1) | MX2009006764A (enExample) |
| NZ (1) | NZ577491A (enExample) |
| WO (1) | WO2008077188A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009266421B2 (en) | 2008-07-02 | 2013-07-11 | Avexa Limited | Compounds having antiviral properties |
| WO2010000030A1 (en) * | 2008-07-02 | 2010-01-07 | Avexa Limited | Thiazopyrimidinones and uses thereof |
| EP2291377B1 (en) * | 2008-07-02 | 2015-02-18 | Avexa Limited | Imidazopyrimidinones and uses thereof |
| CN102336751A (zh) * | 2010-07-16 | 2012-02-01 | 爱维艾珂瑟有限公司 | 新型抗病毒剂 |
| PE20160661A1 (es) | 2013-09-12 | 2016-08-05 | Alios Biopharma Inc | Compuesto de azapiridona y sus usos de los mismos |
| EP3082820B1 (en) * | 2013-12-19 | 2022-07-20 | PTC Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| US10208045B2 (en) | 2015-03-11 | 2019-02-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| EP3310169B1 (en) | 2015-05-30 | 2023-05-17 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| MX382671B (es) | 2015-12-10 | 2025-03-13 | Ptc Therapeutics Inc | Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington |
| JP2019535789A (ja) | 2016-11-28 | 2019-12-12 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを調節する方法 |
| JP7376471B2 (ja) | 2017-06-05 | 2023-11-08 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| CN111372611A (zh) | 2017-06-14 | 2020-07-03 | Ptc医疗公司 | 修饰rna剪接的方法 |
| MX2019015578A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
| MX2019015580A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
| JP7399870B2 (ja) | 2018-03-27 | 2023-12-18 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| EA202092899A1 (ru) | 2018-06-27 | 2021-05-14 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Гетероарильные соединения для лечения болезни гентингтона |
| LT3814357T (lt) | 2018-06-27 | 2024-06-25 | Ptc Therapeutics, Inc. | Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
| JP7765088B2 (ja) | 2019-12-02 | 2025-11-06 | ストーム・セラピューティクス・リミテッド | Ｍｅｔｔｌ３阻害剤としてのポリヘテロ環式化合物 |
| US12070445B2 (en) * | 2021-08-27 | 2024-08-27 | Wisconsin Alumni Research Foundation | System and assay for monitoring production/release of membrane-lytic toxins in bacteria and compounds for modulating same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1052182B (en) | 2000-09-20 | 2005-04-01 | Schering Corporation | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
| BRPI0306214B1 (pt) | 2002-11-20 | 2017-08-08 | Japan Tobacco Inc. | 4-oxoquinoline compound and use of this as a hiv integrase inhibitor |
| CA2548657A1 (en) | 2003-12-18 | 2005-06-30 | Tibotec Pharmaceuticals Ltd. | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
| TW200526635A (en) * | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| WO2006040520A1 (en) | 2004-10-12 | 2006-04-20 | Astrazeneca Ab | Quinazoline derivatives |
| JP5116660B2 (ja) | 2005-03-31 | 2013-01-09 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ | Ｈｉｖインテグラーゼ阻害剤 |
| US7939537B2 (en) * | 2005-10-04 | 2011-05-10 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | HIV integrase inhibitors |
-
2007
- 2007-12-21 EP EP10164218A patent/EP2269992A1/en not_active Withdrawn
- 2007-12-21 KR KR1020097014886A patent/KR20090097194A/ko not_active Ceased
- 2007-12-21 BR BRPI0722411-7A patent/BRPI0722411A2/pt active Search and Examination
- 2007-12-21 CA CA2673183A patent/CA2673183C/en not_active Expired - Fee Related
- 2007-12-21 MX MX2009006764A patent/MX2009006764A/es active IP Right Grant
- 2007-12-21 DK DK07855368.2T patent/DK2114903T3/da active
- 2007-12-21 KR KR1020107008711A patent/KR20100049698A/ko not_active Ceased
- 2007-12-21 AT AT07855368T patent/ATE496898T1/de not_active IP Right Cessation
- 2007-12-21 NZ NZ577491A patent/NZ577491A/en not_active IP Right Cessation
- 2007-12-21 JP JP2009541695A patent/JP5208962B2/ja not_active Expired - Fee Related
- 2007-12-21 CN CN201010148170.6A patent/CN101880280B/zh not_active Expired - Fee Related
- 2007-12-21 WO PCT/AU2007/001980 patent/WO2008077188A1/en not_active Ceased
- 2007-12-21 AR ARP070105884A patent/AR064517A1/es not_active Application Discontinuation
- 2007-12-21 EP EP07855368A patent/EP2114903B1/en active Active
- 2007-12-21 DE DE602007012308T patent/DE602007012308D1/de active Active
- 2007-12-21 BR BRPI0720564-3A patent/BRPI0720564A2/pt not_active IP Right Cessation
- 2007-12-21 US US12/519,273 patent/US8143268B2/en not_active Expired - Fee Related
- 2007-12-21 AU AU2007336703A patent/AU2007336703B9/en not_active Ceased
-
2010
- 2010-03-24 AU AU2010201160A patent/AU2010201160A1/en not_active Abandoned
- 2010-04-23 US US12/766,510 patent/US8207334B2/en not_active Expired - Fee Related
- 2010-06-07 JP JP2010129801A patent/JP2010222370A/ja not_active Withdrawn
- 2010-06-09 AR ARP100102037A patent/AR077043A2/es unknown
-
2012
- 2012-02-27 US US13/405,511 patent/US8859563B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| M. Tisler et al..An improved synthesis of dimethyl diacetoxyfumarate and its condensation with heterocyclic amines.《Organic Preparations and Procedures International》.1990,第22卷(第4期),532-534. * |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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