AU2007336703B9 - Bicyclic pyrimidinones and uses thereof - Google Patents

Bicyclic pyrimidinones and uses thereof Download PDF

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Publication number
AU2007336703B9
AU2007336703B9 AU2007336703A AU2007336703A AU2007336703B9 AU 2007336703 B9 AU2007336703 B9 AU 2007336703B9 AU 2007336703 A AU2007336703 A AU 2007336703A AU 2007336703 A AU2007336703 A AU 2007336703A AU 2007336703 B9 AU2007336703 B9 AU 2007336703B9
Authority
AU
Australia
Prior art keywords
hydroxy
oxo
carboxylic acid
preparation
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007336703A
Other languages
English (en)
Other versions
AU2007336703B2 (en
AU2007336703A1 (en
Inventor
Neil Choi
Jonathan Alan Victor Coates
John Joseph Deadman
William Issa
Eric Dale Jones
Katherine Macfarlane
David Ian Rhodes
Neeranat Thienthong
Nicholas Andrew Vandegraff
Lisa Jane Winfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tali Digital Ltd
Original Assignee
Avexa Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2006907283A external-priority patent/AU2006907283A0/en
Application filed by Avexa Ltd filed Critical Avexa Ltd
Priority to AU2007336703A priority Critical patent/AU2007336703B9/en
Publication of AU2007336703A1 publication Critical patent/AU2007336703A1/en
Priority to AU2010201160A priority patent/AU2010201160A1/en
Application granted granted Critical
Publication of AU2007336703B2 publication Critical patent/AU2007336703B2/en
Publication of AU2007336703B9 publication Critical patent/AU2007336703B9/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2007336703A 2006-12-22 2007-12-21 Bicyclic pyrimidinones and uses thereof Ceased AU2007336703B9 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2007336703A AU2007336703B9 (en) 2006-12-22 2007-12-21 Bicyclic pyrimidinones and uses thereof
AU2010201160A AU2010201160A1 (en) 2006-12-22 2010-03-24 Bicyclic pyrimidinones and uses thereof

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
AU2006907283 2006-12-22
AU2006907283A AU2006907283A0 (en) 2006-12-22 Bicyclic pyrimidinones and uses thereof
AU2007902479 2007-05-09
AU2007902479A AU2007902479A0 (en) 2007-05-09 Bicyclic pyrimidinones and uses thereof (2)
AU2007903401 2007-06-25
AU2007903401A AU2007903401A0 (en) 2007-06-25 Bicyclic pyrimidinodes and uses thereof (3)
AU2007904114 2007-07-31
AU2007904114A AU2007904114A0 (en) 2007-07-31 Bicyclic pyrimidinones and uses thereof (4)
AU2007336703A AU2007336703B9 (en) 2006-12-22 2007-12-21 Bicyclic pyrimidinones and uses thereof
PCT/AU2007/001980 WO2008077188A1 (en) 2006-12-22 2007-12-21 Bicyclic pyrimidinones and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2010201160A Division AU2010201160A1 (en) 2006-12-22 2010-03-24 Bicyclic pyrimidinones and uses thereof

Publications (3)

Publication Number Publication Date
AU2007336703A1 AU2007336703A1 (en) 2008-07-03
AU2007336703B2 AU2007336703B2 (en) 2012-04-12
AU2007336703B9 true AU2007336703B9 (en) 2014-03-27

Family

ID=39562030

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2007336703A Ceased AU2007336703B9 (en) 2006-12-22 2007-12-21 Bicyclic pyrimidinones and uses thereof
AU2010201160A Abandoned AU2010201160A1 (en) 2006-12-22 2010-03-24 Bicyclic pyrimidinones and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2010201160A Abandoned AU2010201160A1 (en) 2006-12-22 2010-03-24 Bicyclic pyrimidinones and uses thereof

Country Status (15)

Country Link
US (3) US8143268B2 (enExample)
EP (2) EP2114903B1 (enExample)
JP (2) JP5208962B2 (enExample)
KR (2) KR20090097194A (enExample)
CN (1) CN101880280B (enExample)
AR (2) AR064517A1 (enExample)
AT (1) ATE496898T1 (enExample)
AU (2) AU2007336703B9 (enExample)
BR (2) BRPI0720564A2 (enExample)
CA (1) CA2673183C (enExample)
DE (1) DE602007012308D1 (enExample)
DK (1) DK2114903T3 (enExample)
MX (1) MX2009006764A (enExample)
NZ (1) NZ577491A (enExample)
WO (1) WO2008077188A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8318732B2 (en) * 2008-07-02 2012-11-27 Avexa Limited Compounds having antiviral properties
WO2010000031A1 (en) * 2008-07-02 2010-01-07 Avexa Limited Imidazopyrimidinones and uses thereof
EP2247601B1 (en) * 2008-07-02 2013-04-10 Avexa Limited Thiazopyrimidinones and uses thereof
CN102336751A (zh) * 2010-07-16 2012-02-01 爱维艾珂瑟有限公司 新型抗病毒剂
CN105764904B (zh) 2013-09-12 2020-02-11 詹森生物制药有限公司 氮杂-吡啶酮化合物及其用途
WO2015105657A1 (en) * 2013-12-19 2015-07-16 Ptc Therapeutics, Inc. Methods for modulating the amount of rna transcripts
WO2016145103A1 (en) 2015-03-11 2016-09-15 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
EP3310169B1 (en) 2015-05-30 2023-05-17 PTC Therapeutics, Inc. Methods for modulating rna splicing
CA3119019C (en) 2015-12-10 2024-06-11 Ptc Therapeutics, Inc. Compounds and methods for treating huntington's disease
JP2019535789A (ja) 2016-11-28 2019-12-12 ピーティーシー セラピューティクス，インコーポレーテッド Ｒｎａスプライシングを調節する方法
EP4151627A1 (en) 2017-06-05 2023-03-22 PTC Therapeutics, Inc. Compounds for treating huntington's disease
CN111372611A (zh) 2017-06-14 2020-07-03 Ptc医疗公司 修饰rna剪接的方法
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
BR112020019373A2 (pt) 2018-03-27 2020-12-29 Ptc Therapeutics, Inc. Compostos para o tratamento da doença de hutington
IL279688B2 (en) 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
KR20210038845A (ko) 2018-06-27 2021-04-08 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료를 위한 헤테로아릴 화합물
CA3139821A1 (en) 2019-05-13 2020-11-19 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
US12195458B2 (en) 2019-12-02 2025-01-14 Storm Therapeutics Limited Polyheterocyclic compounds as METTL3 inhibitors
US12070445B2 (en) * 2021-08-27 2024-08-27 Wisconsin Alumni Research Foundation System and assay for monitoring production/release of membrane-lytic toxins in bacteria and compounds for modulating same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007039218A1 (en) * 2005-10-04 2007-04-12 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044141A2 (en) 2000-09-20 2002-06-06 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
US7176220B2 (en) 2002-11-20 2007-02-13 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as pharmaceutical agent
ATE435222T1 (de) 2003-12-18 2009-07-15 Tibotec Pharm Ltd Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
MX2007004403A (es) 2004-10-12 2007-04-27 Astrazeneca Ab Derivados de quinazolina.
WO2006103399A1 (en) 2005-03-31 2006-10-05 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007039218A1 (en) * 2005-10-04 2007-04-12 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TISLER, M. et al. Org. Prep. & Proc. Intl. (1990), Vol. 22, No. 4, pages 532-534 *

Also Published As

Publication number Publication date
AU2010201160A1 (en) 2010-04-15
JP2010513322A (ja) 2010-04-30
EP2114903A1 (en) 2009-11-11
MX2009006764A (es) 2009-11-26
AR077043A2 (es) 2011-07-27
JP2010222370A (ja) 2010-10-07
CN101880280A (zh) 2010-11-10
WO2008077188A1 (en) 2008-07-03
US20120232035A1 (en) 2012-09-13
EP2114903B1 (en) 2011-01-26
US20100168063A1 (en) 2010-07-01
CN101880280B (zh) 2014-07-16
EP2269992A1 (en) 2011-01-05
BRPI0720564A2 (pt) 2011-08-16
ATE496898T1 (de) 2011-02-15
AR064517A1 (es) 2009-04-08
US8859563B2 (en) 2014-10-14
KR20090097194A (ko) 2009-09-15
BRPI0722411A2 (pt) 2012-06-05
US8207334B2 (en) 2012-06-26
KR20100049698A (ko) 2010-05-12
CA2673183A1 (en) 2008-07-03
EP2114903A4 (en) 2009-12-30
AU2007336703B2 (en) 2012-04-12
HK1131615A1 (en) 2010-01-29
DK2114903T3 (da) 2011-04-18
DE602007012308D1 (de) 2011-03-10
US8143268B2 (en) 2012-03-27
US20110009366A1 (en) 2011-01-13
NZ577491A (en) 2011-06-30
JP5208962B2 (ja) 2013-06-12
AU2007336703A1 (en) 2008-07-03
CA2673183C (en) 2014-06-10

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
SREP Specification republished
MK14 Patent ceased section 143(a) (annual fees not paid) or expired