JP5208962B2 - 二環式ピリミジノンおよびその使用 - Google Patents

二環式ピリミジノンおよびその使用 Download PDF

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Publication number
JP5208962B2
JP5208962B2 JP2009541695A JP2009541695A JP5208962B2 JP 5208962 B2 JP5208962 B2 JP 5208962B2 JP 2009541695 A JP2009541695 A JP 2009541695A JP 2009541695 A JP2009541695 A JP 2009541695A JP 5208962 B2 JP5208962 B2 JP 5208962B2
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JP
Japan
Prior art keywords
alkyl
hydroxy
oxo
carboxylic acid
pyrimidine
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Expired - Fee Related
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JP2009541695A
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English (en)
Japanese (ja)
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JP2010513322A5 (enExample
JP2010513322A (ja
Inventor
エリック・デイル・ジョーンズ
ジョナサン・アラン・ビクター・コーツ
デイビッド・イアン・ローズ
ジョン・ジョセフ・デッドマン
ニコラス・アンドリュー・バンデグラフ
リサ・ジェーン・ウィンフィールド
ネーラナット・ティエントン
ウィリアム・イッサ
ニール・チョイ
キャサリン・マクファーレン
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Tali Digital Ltd
Original Assignee
Avexa Ltd
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Filing date
Publication date
Priority claimed from AU2006907283A external-priority patent/AU2006907283A0/en
Application filed by Avexa Ltd filed Critical Avexa Ltd
Publication of JP2010513322A publication Critical patent/JP2010513322A/ja
Publication of JP2010513322A5 publication Critical patent/JP2010513322A5/ja
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2009541695A 2006-12-22 2007-12-21 二環式ピリミジノンおよびその使用 Expired - Fee Related JP5208962B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
AU2006907283A AU2006907283A0 (en) 2006-12-22 Bicyclic pyrimidinones and uses thereof
AU2006907283 2006-12-22
AU2007902479 2007-05-09
AU2007902479A AU2007902479A0 (en) 2007-05-09 Bicyclic pyrimidinones and uses thereof (2)
AU2007903401 2007-06-25
AU2007903401A AU2007903401A0 (en) 2007-06-25 Bicyclic pyrimidinodes and uses thereof (3)
AU2007904114A AU2007904114A0 (en) 2007-07-31 Bicyclic pyrimidinones and uses thereof (4)
AU2007904114 2007-07-31
PCT/AU2007/001980 WO2008077188A1 (en) 2006-12-22 2007-12-21 Bicyclic pyrimidinones and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010129801A Division JP2010222370A (ja) 2006-12-22 2010-06-07 二環式ピリミジノンおよびその使用

Publications (3)

Publication Number Publication Date
JP2010513322A JP2010513322A (ja) 2010-04-30
JP2010513322A5 JP2010513322A5 (enExample) 2010-06-24
JP5208962B2 true JP5208962B2 (ja) 2013-06-12

Family

ID=39562030

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009541695A Expired - Fee Related JP5208962B2 (ja) 2006-12-22 2007-12-21 二環式ピリミジノンおよびその使用
JP2010129801A Withdrawn JP2010222370A (ja) 2006-12-22 2010-06-07 二環式ピリミジノンおよびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010129801A Withdrawn JP2010222370A (ja) 2006-12-22 2010-06-07 二環式ピリミジノンおよびその使用

Country Status (15)

Country Link
US (3) US8143268B2 (enExample)
EP (2) EP2114903B1 (enExample)
JP (2) JP5208962B2 (enExample)
KR (2) KR20100049698A (enExample)
CN (1) CN101880280B (enExample)
AR (2) AR064517A1 (enExample)
AT (1) ATE496898T1 (enExample)
AU (2) AU2007336703B9 (enExample)
BR (2) BRPI0722411A2 (enExample)
CA (1) CA2673183C (enExample)
DE (1) DE602007012308D1 (enExample)
DK (1) DK2114903T3 (enExample)
MX (1) MX2009006764A (enExample)
NZ (1) NZ577491A (enExample)
WO (1) WO2008077188A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011526248A (ja) * 2008-07-02 2011-10-06 アベキサ・リミテッド 抗ウイルス特性を有する化合物
JP2011526246A (ja) * 2008-07-02 2011-10-06 アベキサ・リミテッド チアゾピリミジノンおよびその使用

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2729656A1 (en) * 2008-07-02 2010-01-07 Avexa Limited Imidazopyrimidinones and uses thereof
CN102336751A (zh) * 2010-07-16 2012-02-01 爱维艾珂瑟有限公司 新型抗病毒剂
JP6448647B2 (ja) 2013-09-12 2019-01-09 アリオス バイオファーマ インク． アザ−ピリドン化合物およびその用途
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
EA036776B1 (ru) 2015-03-11 2020-12-21 Янссен Байофарма, Инк. Соединения азапиридона и способы их применения
WO2016196386A1 (en) 2015-05-30 2016-12-08 Ptc Therapeutics, Inc. Methods for modulating rna splicing
WO2017100726A1 (en) 2015-12-10 2017-06-15 Ptc Therapeutics, Inc. Methods for treatng huntington's disease
EA201991309A1 (ru) 2016-11-28 2019-11-29 Способы модуляции сплайсинга рнк
BR112019025740A2 (pt) 2017-06-05 2020-06-23 Ptc Therapeutics, Inc. Compostos para tratar a doença de huntington
WO2018232039A1 (en) 2017-06-14 2018-12-20 Ptc Therapeutics, Inc. Methods for modifying rna splicing
MX2019015580A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
SG11202009212WA (en) 2018-03-27 2020-10-29 Ptc Therapeutics Inc Compounds for treating huntington's disease
JP7421507B2 (ja) 2018-06-27 2024-01-24 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するためのヘテロ環式およびヘテロアリール化合物
EP3814360B8 (en) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
BR112020026534A2 (pt) 2018-06-27 2021-03-23 Ptc Therapeutics, Inc. Compostos de heteroarila para o tratamento da doença de huntington
BR112022010561A2 (pt) 2019-12-02 2022-11-16 Storm Therapeutics Ltd Compostos poli-heterocíclicos como inibidores de mettl3
US12070445B2 (en) * 2021-08-27 2024-08-27 Wisconsin Alumni Research Foundation System and assay for monitoring production/release of membrane-lytic toxins in bacteria and compounds for modulating same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2233708T3 (es) 2000-09-20 2005-06-16 Schering Corporation Imidazoles sustituidos como agonistas o antagonistas duales de la histamina h1 y la h3.
NZ533641A (en) 2002-11-20 2006-07-28 Japan Tobacco Inc 4-oxoquinoline compounds and utilization thereof as HIV integrase inhibitors
RU2379302C2 (ru) 2003-12-18 2010-01-20 Тиботек Фармасьютикалз Лтд. Аминобензимидазолы и бензимидазолы в качестве ингибиторов репликации респираторно-синцитиального вируса
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
CA2581516C (en) 2004-10-12 2013-06-11 Astrazeneca Ab Quinazoline derivatives
US7981879B2 (en) * 2005-03-31 2011-07-19 Instituto di Ricerchi di Biologia Molecolare P. Angeletti S.p.A. HIV integrase inhibitors
JP5094725B2 (ja) * 2005-10-04 2012-12-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ Ｈｉｖインテグラーゼ阻害剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011526248A (ja) * 2008-07-02 2011-10-06 アベキサ・リミテッド 抗ウイルス特性を有する化合物
JP2011526246A (ja) * 2008-07-02 2011-10-06 アベキサ・リミテッド チアゾピリミジノンおよびその使用

Also Published As

Publication number Publication date
KR20100049698A (ko) 2010-05-12
EP2114903A1 (en) 2009-11-11
KR20090097194A (ko) 2009-09-15
BRPI0722411A2 (pt) 2012-06-05
US8143268B2 (en) 2012-03-27
AU2007336703B9 (en) 2014-03-27
AR077043A2 (es) 2011-07-27
WO2008077188A1 (en) 2008-07-03
EP2114903B1 (en) 2011-01-26
JP2010222370A (ja) 2010-10-07
BRPI0720564A2 (pt) 2011-08-16
AU2007336703A1 (en) 2008-07-03
NZ577491A (en) 2011-06-30
EP2269992A1 (en) 2011-01-05
MX2009006764A (es) 2009-11-26
AR064517A1 (es) 2009-04-08
CN101880280A (zh) 2010-11-10
AU2007336703B2 (en) 2012-04-12
CA2673183C (en) 2014-06-10
EP2114903A4 (en) 2009-12-30
HK1131615A1 (en) 2010-01-29
US8207334B2 (en) 2012-06-26
US8859563B2 (en) 2014-10-14
JP2010513322A (ja) 2010-04-30
AU2010201160A1 (en) 2010-04-15
ATE496898T1 (de) 2011-02-15
CN101880280B (zh) 2014-07-16
CA2673183A1 (en) 2008-07-03
US20110009366A1 (en) 2011-01-13
US20120232035A1 (en) 2012-09-13
US20100168063A1 (en) 2010-07-01
DE602007012308D1 (de) 2011-03-10
DK2114903T3 (da) 2011-04-18

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