KR20100043521A - Composition for promoting hair growth - Google Patents

Abstract

PURPOSE: A composition containing Parthenocissus tricuspidata extract is provided to promote hair growth and hair follicle activation without irritation to scalp. CONSTITUTION: A composition contains 0.01-30 weight% of Parthenocissus tricuspidata extract as an active ingredient. The Parthenocissus tricuspidata extract is collected from pine tree or oak tree. The Parthenocissus tricuspidata extract is isolated using purified water, methanol, ethanol, glycerin, ethylacatate, butylenes glycol, propylene glycol, dichloromethane or hexane solvent at 15-35°C, cooling, filtering and decompress-concentrating or freeze-drying at maximum 50°C. The composition is used in the form of hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair pack, hair shampoo, or treatment.

Description

Composition for promoting hair growth containing ivy extract {Composition for promoting hair growth}

The present invention relates to a composition for promoting hair growth or preventing hair loss or anti-inflammatory or scalp protection, and more particularly, to a hair-related composition containing ivy extract.

Hair is one of the skin appendages, ecologically derived from the epithelium, and forms from the second month of birth. Hair follicles undergo growth, degenerative and resting phases periodically. In anagen, cells of hair follicles actively differentiate to form growth hairs. Stop and move to telogen. Most growers take three years, three decades in recession, and three months in rest.

In general, the causes of hair loss include genetic factors, progression of aging, drug use, radiation therapy and post-stress stress.The main causes of hair loss from a biochemical and physiological point of view are hyperactivity, problems with scalp blood circulation and hair. It is known to lack nutrients essential for metabolism. Although these factors alone can cause hair loss, a combination of hair loss factors may lead to synergism, accelerating alopecia and worsening symptoms. In particular, if genetic factors or acquired special conditions cause the production, change, recognition, and signaling of the male hormones to become overly active, hair follicle tissues tend to prematurely age, which is likely to cause premature baldness. In addition, dysfunction of the scalp due to genetic factors, aging, western high-fat lifestyle and other external factors, or atherosclerosis, etc., can cause disorders in the smooth hair metabolism because blood circulation disorders occur easily.

On the other hand, a number of enzymes necessary to perform the metabolic activity of the human body, including hair metabolism, properly produced and nutrients such as hormones, vitamins, minerals, essential amino acids and lipids must be supplied in order to perform normal activities, a very narrow range of temperature And maintenance of pH conditions. However, when the body is exposed to long-term stresses such as excessive physical dissipation, serious illness, chemotherapy and nutritional imbalances, the body tends to maintain homeostasis by focusing these metabolic elements on more essential tissues for survival. The problem of hair loss and hair regrowth progresses toward hair loss as the priority of hair-lowering action that is lowered in the problem is slowed down. These nutrients cause hair loss after alopecia areata or radiation and chemotherapy, and also accelerate hair loss due to genetic factors and aging.

Recently, due to overuse of environmental factors such as air pollution, mental stress, and hair beauty products, alopecia, often called baldness, is often caused by round or irregular round shape, and hair loss is gradually getting low. ought.

On the other hand, the external treatment methods of baldness caused by the above factors include scalp flap, hair loss site and scalp augmentation and autologous hair transplantation. The economic and mental burden of the patient is very high, so it is difficult to be widely used.

Various external preparations are used. Minoxidil, which is certified by the US FDA, has capillary expansion function to prevent hair loss by applying it to the scalp, but it must be applied twice daily for 3 to 4 hours. There is some discomfort to stay to some effect. In addition, the corresponding effects are insignificant, and side effects such as itching and irritation appear. The FDA-approved oral drug phytasteride (finasteride) inhibits the production of DHT (5α-dihydrotestosterone), a male hormone that causes hair loss, and is known to exhibit hair growth or hair loss inhibitory effects when taken for 6 months to 1 year. However, if you stop taking the problem to return to its original state within two months, sexual dysfunction, such as decreased libido, erectile dysfunction, and women have the risk of birth defects.

Accordingly, an object of the present invention is to provide a composition for promoting hair growth, which contains an ivy extract having an excellent effect on inhibiting hair growth and hair loss while reducing objection from consumers using natural extracts.

In order to achieve the above object, the present invention provides a composition for promoting hair growth, comprising ivy extract as an active ingredient.

The present invention also provides a composition for preventing hair loss, an anti-inflammatory composition and a composition for protecting the scalp, characterized in that it contains an ivy extract as an active ingredient.

Hereinafter will be described in detail with respect to the problem solving means of the present invention.

Ivy ( Parthenocissus tricuspidata ) is a deciduous broad-leaved plant belonging to the dicotyledonous buckthorn tree grape family, which grows on stone walls, rocks or tree trunks. The stem grows more than 10m when fully grown, and the leaves are 10 ~ 20cm wide, egg-shaped, pointed at the tip of the leaf, split into three, and have irregular teeth on the edges. Flower is bisexual, blooms in yellow-green in June-July, with a large number of flower stalks from the tip of branch or leaf axil. Fruits are covered with white powder, 6-8mm in diameter, and ripen black in August-October. These ivy are known to relieve the blood in one shot, relieve pain in the joints and muscles. In addition, the ivy contains a large amount of vitamin C to restore red skin, tanned skin and promote blood circulation to help skin regeneration.

On the other hand, the composition for promoting hair growth of the present invention essentially contains ivy extract, the ivy extract promotes hair growth and hair root cell activity, less irritation to the skin, and has an effect on the hair growth through the anti-inflammatory action It is because it proved by the experiment example that it exerts.

On the other hand, the ivy used in the present invention is not limited to a specific kind, but preferably is taken from pine or oak, the extract of the ivy collected from the pine or oak is excellent in hair growth field and radish to the scalp Because it is a stimulus.

On the other hand, the ivy extract contained in the present invention is not limited to those obtained by a specific method, and may be any one obtained through a conventionally used plant extraction method, preferably 1 part by weight of purified water 1-5 parts by weight of one or more solvents selected from methanol, ethanol, glycerine, ethyl acetate, butylene glycol, propylene glycol, dichloromethane and hexane are added and extracted at 15-35 ° C., followed by cooling and filtration. It is preferably obtained by concentration under reduced pressure or lyophilization at 50 ℃.

On the other hand, the amount of the ivy extract to be added to the composition of the present invention is not limited to a specific range, but preferably 0.01 to 30% by weight based on the total weight of the composition, because it is efficient compared to the amount of material input and excellent hair growth effect to be.

On the other hand, the present invention is not limited to a specific form, and may be in the form of hair or scalp-related products commonly used, for example, hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, Hair conditioners, hair shampoos, hair rinses, hair packs and hair treatments.

In addition, the present invention provides a composition for preventing hair loss, an anti-inflammatory composition and a composition for protecting the scalp, characterized in that it comprises an ivy extract as an active ingredient, the ivy is preferably taken from pine or oak, ivy The preparation method of the vine extract and the amount added to the composition and the form of the composition is consistent with the above.

As described above, the present invention promotes hair growth and activity of hair root cells without irritating the scalp, and in the case of hair loss due to inflammatory expression, has an effect of promoting hair growth through an anti-inflammatory action.

In addition, the present invention has the advantage of reducing the rejection from the consumer by containing a natural extract.

Hereinafter, the configuration and operation of the present invention will be described in more detail in the following Examples, but the scope of the present invention is not limited to the following Examples, but includes modifications of equivalent technical spirit.

Example 1: Preparation of ivy extract

The ivy is collected from oak, pine, and cement to leaves, stems, and roots, and then chopped and shaded. whatman) # 10 filter.

The filtered extract was concentrated under reduced pressure and lyophilized at 50 ° C. or lower to obtain an ivy extract.

Experimental Example 1: Measurement of hair growth promoting effect

Ivy extract extracted from oak prepared in Example 1 (Example 1), Ivy extract extracted from pine (Example 2), Ivy extract prepared from cement (Example 3) And hair growth promoting effect of the positive control containing 3% Minoxidil (Minoxidil) which is generally used as a hair loss prevention and hair growth promoter.

To measure the effect of promoting hair growth, the 6-week-old black mouse (C57BL / 6, male), a dormant hair with dorsal skin color showing 'pink color', was purified for 7 days, and the back hair was then 'animal clipper'. Shaved off, and 6 animals were assigned to each experimental group. The next day, 0.2 mL of Example 1 to Example 3 and the positive control were sufficiently applied using a brush to the central part such as hair shaving. After each sample was applied, massage was performed for about 3 minutes, rinsed well with distilled water, and sample treatment was performed twice daily and the condition was observed for 3 weeks. Since the hair growth process can not be compared and verified, the experiment was performed for about 3 weeks, and the experiment was terminated when the hair growth of the most effective raw material progressed more than 95%. To compare the length of hair and hair growth over time, the control group was observed in natural growth without applying test substances.

Sample Name Indicators Elapsed days 7 days 14 days 21st Control Hair length (mm) 0.57 ± 0.15 1.32 ± 0.27 2.15 ± 0.36 % Growth 13.9 32.2 52.4 Positive control group Hair length (mm) 1.40 ± 0.18 2.93 ± 0.34 3.75 ± 0.42 % Growth 34.1 71.5 91.5 Example 1 Hair length (mm) 0.95 ± 0.19 2.46 ± 0.23 3.82 ± 0.28 % Growth 23.2 60.0 93.2 Example 2 Hair length (mm) 1.13 ± 0.15 2.51 ± 0.19 3.97 ± 0.31 % Growth 27.6 61.2 96.8 Example 3 Hair length (mm) 0.82 ± 0.09 2.17 ± 0.20 3.08 ± 0.22 % Growth 20.0 52.9 75.1

As a result of measuring the hair growth promoting effect (Table 1 and FIG. 1), Example 1 and Example 2 showed an excellent hair growth effect than the minoxidil (positive control) used as a hair growth promoter, Example 3 was slightly sluggish The hair growth effect was superior to that of the control group. And the mice treated with the samples of Example 1 and Example 2 and the positive control on day 21, the hair was almost grown on the back, but the control group was not much growth, Example 3 showed better hair growth than the control.

From the above results, it was confirmed that the ivy extract promotes hair growth, from which it can be inferred that the hair promoting effect of the present invention is excellent.

Experimental Example 2: Measurement of the degree of promotion of hair root cell activity

In the same manner as in Experiment 1, three animals were examined at the end of the 7 days after the start of the test, and 3 animals at the end of the test (21 days) were measured to determine the degree of promotion of hair root cell activity of each sample.

The sample application site was removed using an anatomizer, fixed with formalin, and dewatered with alcohol and xylene step by step to remove paraffin, and then 5 µm sections were removed using a tissue sectioner. The paraffin was removed with alcohol and xylene again. The tissues were stained with 'Hematoxylin & Eosin (H & E)' and histological changes of hair follicle tissues were observed by light microscope.

As a result of measuring the degree of promoting hair follicle activity (Fig. 2), the black part is the appearance of the hair growing in the skin, Examples 1 to 3 have a high density of hair follicle cells, the number of black hair cells In particular, the density of hair follicle cells of Examples 1 and 2 was high.

From the above results, it was confirmed that the ivy extract promotes hair root cell activity, from which it can be deduced that the degree of activity promotion of the hair root cells of the present invention is excellent.

Experimental Example  3: skin irritation measurement

Skin irritation of Example 1, Example 2, and Example 3 and the control group (sample no treatment) as in Experimental Example 1 was measured.

Rabbits were epilated 24 hours before each sample was treated, and divided into treatment and control sections of normal and wound skin. The coating method was applied once to the application site by 1g of sample per rabbit. The control group was applied in equal amounts of sterile saline and covered with gauze. In order to suppress evaporation of the sample, it was covered with a solid material foil having no permeability and reactivity, fixed with a tape, and then applied for 24 hours, 72 hours, and 120 hours.

After the application time was rinsed lightly with physiological saline, the appearance, feed and beverage consumption and clinical symptoms were observed daily for a week.

The skin reaction was evaluated using the 'toxicity test criteria' of medicines, etc., and the method of calculating 'PII (Primary Irritation Index)' of 'Draize', which generally uses the degree of irritation to the skin, was evaluated. The results are shown in Table 2 below (0; no stimulation, 5; strong stimulation).

Sample Name P.I.I Result 24 hours 72 hours 120 hours Control 0.1 (no irritation) 0.1 (no irritation) 0.1 (no irritation) Example 1 0.4 (low stimulation) 0.1 (no irritation) 0.1 (no irritation) Example 2 0.3 (low stimulation) 0.1 (no irritation) 0.1 (no irritation) Example 3 0.9 (low stimulation) 0.6 (low stimulation) 0.3 (low stimulation)

As a result of measuring the skin irritation (Table 2), PII of 0.3 to 0.4 was shown at 24 hours of application of Examples 1 and 2, and 0.1 at 72 hours and 0.1 at 120 hours of application. In Example 3, the degree of stimulation decreased with time.

From the above results, it was confirmed that the composition of the present invention is less irritating to the skin.

Experimental Example  4: skin Inflammation  Hair growth measurement

The effect of Example 2 (Ivy vine extract taken from pine) from Experimental Example 2 on the hair growth of mice with skin inflammation was measured.

Experimental method was carried out in the same manner as in Experiment 1, was observed for 2 weeks.

As a result of measuring hair growth promotion during skin inflammation (FIG. 3), it was shown that the hair follicle cells died and did not develop hair when the inflammatory reaction proceeded. In the control group, hair growth did not progress as the inflammation-induced portion worsened, but in Example 2, hair growth was normally performed even though inflammation was induced.

From the above results, it was confirmed that the ivy extract effectively prevents hair loss due to inflammation and promotes hair growth, from which the present invention can infer the fact that the hair growth promoting effect is excellent even when inflammation occurs.

1 is compared with the control material and the positive control group (3% minoxidil) according to the test material of Example 1 (oak ivy extract), Example 2 (pine ivy extract) and Example 3 (cement ivy extract) Figure shows external morphological changes indicating the hair growth process.

FIG. 2 shows follicle tissues according to the test substance application of the control group and the positive control group (3% minoxidil) and Example 1 (oak ivy extract), Example 2 (pine ivy extract) and Example 3 (cement ivy extract) Figure shows the histological change of.

Figure 3 is a view showing the external morphological changes showing the hair growth process in the inflammation site according to the application of Example 2 (pine ivy extract) compared to the control.

Claims (20)

A composition for promoting hair growth, comprising ivy extract as an active ingredient. The method of claim 1, Ivy, Composition for promoting hair growth, characterized in that collected from pine or oak. The method of claim 1, Ivy extract, 1 to 5 parts by weight of at least one solvent selected from purified water, methanol, ethanol, glycerine, ethyl acetate, butylene glycol, propylene glycol, dichloromethane and hexane was added to 1 part by weight of ivy, and extracted at 15 to 35 ° C. After cooling and filtering, the composition for promoting hair growth, characterized in that obtained by concentrating under reduced pressure or lyophilization at a maximum of 50 ℃. The method of claim 1, The amount of ivy extract added, Hair growth promoting composition, characterized in that added to 0.01 to 30% by weight based on the total weight of the composition. The method of claim 1, The composition, Hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair shampoo, hair rinse, hair pack and hair treatment composition for promoting hair growth, characterized in that it is prepared in the form of any one of the hair treatment. Hair loss prevention composition comprising ivy extract as an active ingredient. The method of claim 6, Ivy, Hair loss prevention composition characterized in that collected from pine or oak. The method of claim 6, Ivy extract, 1 to 5 parts by weight of at least one solvent selected from purified water, methanol, ethanol, glycerine, ethyl acetate, butylene glycol, propylene glycol, dichloromethane and hexane was added to 1 part by weight of ivy, and extracted at 15 to 35 ° C. After cooling and filtering, the composition for preventing hair loss, characterized in that obtained by concentrated under reduced pressure or lyophilized at a maximum of 50 ℃. The method of claim 6, The amount of ivy extract added, Hair loss prevention composition, characterized in that added 0.01 to 30% by weight based on the total weight of the composition. The method of claim 6, The composition, Hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair shampoo, hair rinse, hair pack and hair treatment composition, characterized in that it is prepared in the form of any one of. An anti-inflammatory composition comprising ivy extract as an active ingredient. The method of claim 11, Ivy, Anti-inflammatory composition, characterized in that collected from pine or oak. The method of claim 11, Ivy extract, 1 to 5 parts by weight of at least one solvent selected from purified water, methanol, ethanol, glycerine, ethyl acetate, butylene glycol, propylene glycol, dichloromethane and hexane was added to 1 part by weight of ivy, and extracted at 15 to 35 ° C. After cooling and filtering, the anti-inflammatory composition, characterized in that obtained by concentrated under reduced pressure or lyophilized at up to 50 ℃. The method of claim 11, The amount of ivy extract added, An anti-inflammatory composition, characterized in that added 0.01 to 30% by weight based on the total weight of the composition. The method of claim 11, The composition, Hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair shampoo, hair rinse, hair pack and anti-inflammatory composition characterized in that it is prepared in the form of any one of hair treatments. Composition for protecting the scalp, comprising ivy extract as an active ingredient. The method of claim 16, Ivy, Composition for protecting the scalp, characterized in that taken from pine or oak. The method of claim 16, Ivy extract, 1 to 5 parts by weight of at least one solvent selected from purified water, methanol, ethanol, glycerine, ethyl acetate, butylene glycol, propylene glycol, dichloromethane and hexane was added to 1 part by weight of ivy, and extracted at 15 to 35 ° C. After cooling and filtering, the composition for protecting the scalp, which is obtained by concentration under reduced pressure or lyophilization at a maximum of 50 ° C. The method of claim 16, The amount of ivy extract added, A composition for protecting the scalp, characterized in that added to 0.01 to 30% by weight based on the total weight of the composition. The method of claim 16, The composition, Hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair shampoo, hair rinse, hair pack and hair treatment composition characterized in that it is prepared in the form of any one of the hair treatment.

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