KR20090104017A - Ａ베타 항체 비경구 제제 - Google Patents
Ａ베타 항체 비경구 제제 Download PDFInfo
- Publication number
- KR20090104017A KR20090104017A KR1020097013954A KR20097013954A KR20090104017A KR 20090104017 A KR20090104017 A KR 20090104017A KR 1020097013954 A KR1020097013954 A KR 1020097013954A KR 20097013954 A KR20097013954 A KR 20097013954A KR 20090104017 A KR20090104017 A KR 20090104017A
- Authority
- KR
- South Korea
- Prior art keywords
- histidine
- antibody
- formulation
- tween
- abeta antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 229960002885 histidine Drugs 0.000 claims description 61
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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Landscapes
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170056713A (ko) * | 2011-05-02 | 2017-05-23 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
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| TW200530269A (en) | 2003-12-12 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Anti-Mpl antibodies |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
| EP1870458B1 (en) | 2005-03-31 | 2018-05-09 | Chugai Seiyaku Kabushiki Kaisha | sc(Fv)2 STRUCTURAL ISOMERS |
| CN101262885B (zh) | 2005-06-10 | 2015-04-01 | 中外制药株式会社 | 含有sc(Fv)2的药物组合物 |
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| RU2563823C2 (ru) * | 2008-11-17 | 2015-09-20 | Дженентек, Инк. | Способ и композиция для уменьшения агрегации макромолекул при физиологических условиях |
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| WO2010069858A1 (en) * | 2008-12-19 | 2010-06-24 | F. Hoffmann-La Roche Ag | Pharmaceutical composition |
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| BR112012012080B1 (pt) * | 2009-11-20 | 2022-11-29 | Biocon Limited | Formulações de histidina-trealose do anticorpo t1h |
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| EA201201227A1 (ru) | 2010-03-03 | 2013-04-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Бипаратопные а-бета-связывающие полипептиды |
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| US9221900B2 (en) | 2010-07-30 | 2015-12-29 | Ac Immune S.A. | Methods for identifying safe and functional humanized antibodies |
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| WO2012028683A1 (en) * | 2010-09-02 | 2012-03-08 | Novartis Ag | Antibody gel system for sustained drug delivery |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| WO2012151199A1 (en) | 2011-05-02 | 2012-11-08 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
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| KR102669174B1 (ko) * | 2015-08-19 | 2024-06-10 | 아스트라제네카 아베 | 안정한 항-ｉｆｎａｒ1 제형 |
| KR20180037056A (ko) * | 2015-09-22 | 2018-04-10 | 화이자 인코포레이티드 | 치료학적 단백질 제형의 제조 방법 및 이러한 방법에 의해 생산된 항체 제형 |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| PE20231655A1 (es) | 2015-10-02 | 2023-10-17 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso |
| CN106620691B (zh) * | 2015-11-04 | 2020-08-21 | 信达生物制药(苏州)有限公司 | 一种重组全人源抗ctla-4单克隆抗体制剂及其应用 |
| AU2016380988B2 (en) | 2015-12-30 | 2022-07-21 | Genentech, Inc. | Formulations with reduced degradation of polysorbate |
| CN106199007B (zh) * | 2016-08-03 | 2017-04-05 | 烟台普罗吉生物科技发展有限公司 | 蛋白保护剂 |
| KR102514528B1 (ko) | 2016-10-21 | 2023-03-27 | 바이오콘 리미티드 | 루푸스 치료를 위한 단일클론항체 및 이의 치료방법 |
| CN106913869B (zh) * | 2017-03-17 | 2020-07-28 | 信达生物制药(苏州)有限公司 | 一种抗ctla-4单克隆抗体制剂及其应用 |
| EP3606964A4 (en) | 2017-04-03 | 2020-12-09 | Immunomedics, Inc. | SUBCUTANE ADMINISTRATION OF ANTIBODY DRUG CONJUGATES FOR CANCER THERAPY |
| EP4233901A3 (en) * | 2017-08-22 | 2023-09-06 | Biogen MA Inc. | Pharmaceutical compositions containing anti-beta amyloid antibodies |
| CN108373494A (zh) * | 2018-02-27 | 2018-08-07 | 武汉伊艾博科技有限公司 | 一种防止重组蛋白质降解的保护技术 |
| JP7266108B2 (ja) | 2019-02-18 | 2023-04-27 | イーライ リリー アンド カンパニー | 治療用抗体製剤 |
| CN112618482A (zh) * | 2019-09-24 | 2021-04-09 | 江苏恒瑞医药股份有限公司 | 新型蛋白制剂 |
| CN112741804A (zh) * | 2019-10-31 | 2021-05-04 | 上海君实生物医药科技股份有限公司 | 含有抗pd-l1抗体的稳定制剂 |
| CN113116812A (zh) * | 2019-12-30 | 2021-07-16 | 百奥泰生物制药股份有限公司 | 含抗Trop2抗体-药物偶联物的制剂及其制备方法和应用 |
| WO2022072255A1 (en) * | 2020-09-30 | 2022-04-07 | Merck Sharp & Dohme Corp. | Binding proteins and antigen binding fragments thereof that bind abeta |
| US20240417451A1 (en) | 2023-05-31 | 2024-12-19 | Hoffmann-La Roche Inc. | Therapeutic Use of Bispecific Anti-Abeta/TfR Antibodies |
| CN117088974B (zh) * | 2023-08-14 | 2024-02-13 | 武汉健昊生物科技有限公司 | 一种抗体保存液 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6685940B2 (en) * | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US20030113316A1 (en) * | 2001-07-25 | 2003-06-19 | Kaisheva Elizabet A. | Stable lyophilized pharmaceutical formulation of IgG antibodies |
| AR038568A1 (es) * | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| EP2335725B1 (en) * | 2003-04-04 | 2016-10-12 | Genentech, Inc. | High concentration antibody and protein formulations |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| BRPI0606867A2 (pt) * | 2005-01-28 | 2009-07-21 | Wyeth Corp | formulação lìquida; forma de dosagem unitária farmacêutica; kit; recipiente; método para aumentar a estabilidade de um polipeptìdeo de ligação a antìgeno numa formulação; método para preparar uma forma de dosagem unitária farmacêutica; formulação estável; formulação; e produto terapêutico |
| AR057233A1 (es) * | 2005-12-12 | 2007-11-21 | Hoffmann La Roche | Glicosilacion en la region variable |
| RU2008142359A (ru) * | 2006-03-28 | 2010-05-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Композиция человеческого моноклонального антитела к igf-1r |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170056713A (ko) * | 2011-05-02 | 2017-05-23 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
| KR101875155B1 (ko) * | 2011-05-02 | 2018-07-09 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
| KR20180080354A (ko) * | 2011-05-02 | 2018-07-11 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
Also Published As
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| CL2007003583A1 (es) | 2008-07-18 |
| IL198963A0 (en) | 2011-08-01 |
| WO2008071394A1 (en) | 2008-06-19 |
| NO20092586L (no) | 2009-07-17 |
| AR064220A1 (es) | 2009-03-18 |
| CR10823A (es) | 2009-08-12 |
| RU2009126420A (ru) | 2011-01-20 |
| MA30975B1 (fr) | 2009-12-01 |
| CA2671968A1 (en) | 2008-06-19 |
| CN101553504A (zh) | 2009-10-07 |
| EP2094729A1 (en) | 2009-09-02 |
| PE20081477A1 (es) | 2008-10-18 |
| BRPI0721097A2 (pt) | 2014-07-01 |
| US20110070225A1 (en) | 2011-03-24 |
| MX2009006199A (es) | 2009-06-22 |
| ZA200904014B (en) | 2010-04-28 |
| AU2007331712A2 (en) | 2009-07-30 |
| AU2007331712A1 (en) | 2008-06-19 |
| JP2010512356A (ja) | 2010-04-22 |
| ECSP099403A (es) | 2009-07-31 |
| TW200831133A (en) | 2008-08-01 |
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