KR20090029200A - 우울증 질환에 대한 치료 - Google Patents
우울증 질환에 대한 치료 Download PDFInfo
- Publication number
- KR20090029200A KR20090029200A KR1020087029908A KR20087029908A KR20090029200A KR 20090029200 A KR20090029200 A KR 20090029200A KR 1020087029908 A KR1020087029908 A KR 1020087029908A KR 20087029908 A KR20087029908 A KR 20087029908A KR 20090029200 A KR20090029200 A KR 20090029200A
- Authority
- KR
- South Korea
- Prior art keywords
- antagonist
- disorder
- antagonists
- antidepressant
- way
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 238000000034 method Methods 0.000 claims abstract description 20
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- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960003987 melatonin Drugs 0.000 claims abstract description 7
- -1 benzothiadiazide Chemical compound 0.000 claims description 46
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- 239000002207 metabolite Substances 0.000 claims description 20
- 229940005513 antidepressants Drugs 0.000 claims description 18
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 16
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- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 claims description 5
- 229960002629 agomelatine Drugs 0.000 claims description 5
- YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 claims description 5
- 239000000164 antipsychotic agent Substances 0.000 claims description 5
- 208000028683 bipolar I disease Diseases 0.000 claims description 5
- NRBNGHCYDWUVLC-UHFFFAOYSA-N mtep Chemical compound S1C(C)=NC(C#CC=2C=NC=CC=2)=C1 NRBNGHCYDWUVLC-UHFFFAOYSA-N 0.000 claims description 5
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims description 5
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- 101800001144 Arg-vasopressin Proteins 0.000 claims description 4
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- 108010047068 Melanin-concentrating hormone receptor Proteins 0.000 claims description 4
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims description 4
- 201000009916 Postpartum depression Diseases 0.000 claims description 4
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims description 4
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- 229960002073 sertraline Drugs 0.000 claims description 4
- VLZBRVJVCCNPRJ-KPHUOKFYSA-N (1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-1-cyclopropanecarboxylic acid Chemical compound C([C@@H]1[C@](CC2C3=CC=CC=C3OC3=CC=CC=C32)(N)C(O)=O)[C@@H]1C(O)=O VLZBRVJVCCNPRJ-KPHUOKFYSA-N 0.000 claims description 3
- FERIKTBTNCSGJS-OBLUMXEWSA-N (1r,2s)-4-aminocyclopentane-1,2,4-tricarboxylic acid Chemical compound OC(=O)C1(N)C[C@H](C(O)=O)[C@H](C(O)=O)C1 FERIKTBTNCSGJS-OBLUMXEWSA-N 0.000 claims description 3
- KAGBHVBIOJBGBD-NINOIYOQSA-N (1r,5s)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane;hydrochloride Chemical compound Cl.C1=C(Cl)C(Cl)=CC=C1[C@]1(CNC2)[C@@H]2C1 KAGBHVBIOJBGBD-NINOIYOQSA-N 0.000 claims description 3
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- YXTROGRGRSPWKL-UHFFFAOYSA-N 1-benzoylpiperidine Chemical compound C=1C=CC=CC=1C(=O)N1CCCCC1 YXTROGRGRSPWKL-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US74786106P | 2006-05-22 | 2006-05-22 | |
| US60/747,861 | 2006-05-22 |
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| KR20090029200A true KR20090029200A (ko) | 2009-03-20 |
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| Country | Link |
|---|---|
| US (1) | US20090306137A1 (https=) |
| EP (1) | EP2029136A4 (https=) |
| JP (1) | JP2009538331A (https=) |
| KR (1) | KR20090029200A (https=) |
| AU (1) | AU2007253684A1 (https=) |
| BR (1) | BRPI0711872A2 (https=) |
| CA (1) | CA2652416A1 (https=) |
| MX (1) | MX2008014843A (https=) |
| RU (1) | RU2008150624A (https=) |
| WO (1) | WO2007137227A1 (https=) |
| ZA (1) | ZA200809528B (https=) |
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| KR101484405B1 (ko) * | 2013-08-14 | 2015-01-19 | 서울대학교산학협력단 | Ｎｉｎｊｕｒｉｎ１ 결핍 유래의 강박증 예방 또는 치료용 약학적 조성물 |
| RU2802516C1 (ru) * | 2019-11-27 | 2023-08-30 | Нейрорайв Инк | Комбинированная терапия циклосерином и литием для лечения депрессии |
| US12303530B2 (en) | 2019-11-27 | 2025-05-20 | Neurorive Inc | Combination therapy of cycloserine and lithium for the treatment of depression |
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| US9095572B2 (en) | 2009-01-09 | 2015-08-04 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| EP2385829B1 (en) | 2009-01-09 | 2018-08-01 | Board of Regents of the University of Texas System | Pro-neurogenic compounds |
| MX2012007365A (es) * | 2009-12-23 | 2012-08-15 | Lupin Ltd | Composiciones farmaceuticas de liberacion lenta de iloperidona. |
| FR2956031B1 (fr) * | 2010-02-11 | 2012-03-02 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble obsessionnel compulsif (toc) |
| UY33869A (es) | 2011-01-17 | 2012-08-31 | Takeda Pharmaceutical | Comprimido dispersable por vía oral |
| US8426461B2 (en) | 2011-01-17 | 2013-04-23 | Takeda Pharmaceutical Company Limited | Orally dispersible tablet |
| FR2978916B1 (fr) * | 2011-08-10 | 2013-07-26 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
| RU2465895C1 (ru) * | 2011-09-08 | 2012-11-10 | Государственное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарева" | Способ лечения депрессивного невроза |
| WO2013054582A1 (en) * | 2011-10-14 | 2013-04-18 | Takeda Pharmaceutical Company Limited | Orally dispersible tablet |
| PE20141906A1 (es) * | 2012-03-12 | 2014-12-05 | Janssen Pharmaceutica Nv | Esketamina para el tratamiento de la depresion refractaria al tratamiento o resistente al tratamiento |
| CN108938632A (zh) * | 2012-03-14 | 2018-12-07 | 万达制药公司 | 用于治疗精神疾病的伊潘立酮代谢物及其应用 |
| HK1207304A1 (en) * | 2012-04-23 | 2016-01-29 | Hmnc Value Gmbh | Crhr1 antagonists for use in the treatment of patients having crh overactivity |
| BR112014028446A2 (pt) | 2012-05-18 | 2017-10-24 | Vanda Pharmaceuticals Inc | composto isolado, composição farmacêutica, método de tratamento ou prevenção de pelo menos um de doenças, distúrbios ou condições seguintes, e, método de tratamento ou prevenção de um distúrbio de ritmo circadiano ou distúrbio com um componente circadiano em um indivíduo |
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| WO2015112642A1 (en) | 2014-01-21 | 2015-07-30 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
| RU2571546C1 (ru) * | 2014-07-14 | 2015-12-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации | Способ дифференцированной диагностики и терапии синдрома ночной еды |
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| US20050203130A1 (en) * | 2003-12-02 | 2005-09-15 | Erik Buntinx | Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
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- 2007-05-21 US US12/301,675 patent/US20090306137A1/en not_active Abandoned
- 2007-05-21 JP JP2009512244A patent/JP2009538331A/ja active Pending
- 2007-05-21 EP EP07783990A patent/EP2029136A4/en not_active Ceased
- 2007-05-21 CA CA002652416A patent/CA2652416A1/en not_active Abandoned
- 2007-05-21 BR BRPI0711872-4A patent/BRPI0711872A2/pt not_active IP Right Cessation
- 2007-05-21 KR KR1020087029908A patent/KR20090029200A/ko not_active Ceased
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- 2007-05-21 RU RU2008150624/14A patent/RU2008150624A/ru not_active Application Discontinuation
- 2007-05-21 WO PCT/US2007/069373 patent/WO2007137227A1/en not_active Ceased
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2008
- 2008-11-07 ZA ZA200809528A patent/ZA200809528B/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101484405B1 (ko) * | 2013-08-14 | 2015-01-19 | 서울대학교산학협력단 | Ｎｉｎｊｕｒｉｎ１ 결핍 유래의 강박증 예방 또는 치료용 약학적 조성물 |
| WO2015023054A1 (ko) * | 2013-08-14 | 2015-02-19 | 서울대학교산학협력단 | Ｎｉｎｊｕｒｉｎ１ 결핍을 이용한 강박증 동물모델 |
| RU2802516C1 (ru) * | 2019-11-27 | 2023-08-30 | Нейрорайв Инк | Комбинированная терапия циклосерином и литием для лечения депрессии |
| US12303530B2 (en) | 2019-11-27 | 2025-05-20 | Neurorive Inc | Combination therapy of cycloserine and lithium for the treatment of depression |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2008150624A (ru) | 2010-06-27 |
| US20090306137A1 (en) | 2009-12-10 |
| BRPI0711872A2 (pt) | 2011-12-06 |
| ZA200809528B (en) | 2009-11-25 |
| CA2652416A1 (en) | 2007-11-29 |
| WO2007137227A1 (en) | 2007-11-29 |
| EP2029136A4 (en) | 2010-01-06 |
| AU2007253684A1 (en) | 2007-11-29 |
| MX2008014843A (es) | 2008-12-05 |
| JP2009538331A (ja) | 2009-11-05 |
| EP2029136A1 (en) | 2009-03-04 |
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