KR20080110816A

KR20080110816A - 퓨린 화합물 및 이의 사용 방법

퓨린 화합물 및 이의 사용 방법 Download PDF

Info

Publication number: KR20080110816A
Authority: KR; South Korea
Prior art keywords: formula; alkyl; compound; monocyclic; subject
Prior art date: 2006-03-23
Legal status : Withdrawn

Application number

KR1020087025097A

Other languages

English (en)

Korean (ko)

Inventor

앤드류 엘. 살즈만

프라카쉬 자그타프

Original Assignee

이노텍 파마슈티컬스 코포레이션

Priority date

2006-03-23

Filing date

2007-03-22

Publication date

2008-12-19

2007-03-22 Application filed by 이노텍 파마슈티컬스 코포레이션 filed Critical 이노텍 파마슈티컬스 코포레이션

2008-12-19 Publication of KR20080110816A publication Critical patent/KR20080110816A/ko

Status Withdrawn legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims description 243
125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title description 311
-1 purine compound Chemical class 0.000 claims abstract description 447
239000000203 mixture Substances 0.000 claims abstract description 109
210000002216 heart Anatomy 0.000 claims abstract description 73
238000011282 treatment Methods 0.000 claims abstract description 67
208000010125 myocardial infarction Diseases 0.000 claims abstract description 46
230000037323 metabolic rate Effects 0.000 claims abstract description 45
208000008589 Obesity Diseases 0.000 claims abstract description 22
235000020824 obesity Nutrition 0.000 claims abstract description 22
206010012601 diabetes mellitus Diseases 0.000 claims abstract description 20
206010063837 Reperfusion injury Diseases 0.000 claims abstract description 16
230000000302 ischemic effect Effects 0.000 claims abstract description 16
208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 15
208000012902 Nervous system disease Diseases 0.000 claims abstract description 14
208000010399 Wasting Syndrome Diseases 0.000 claims abstract description 14
230000004224 protection Effects 0.000 claims abstract description 10
150000001875 compounds Chemical class 0.000 claims description 253
125000000217 alkyl group Chemical group 0.000 claims description 237
125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 213
125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 168
150000003839 salts Chemical class 0.000 claims description 109
125000001475 halogen functional group Chemical group 0.000 claims description 62
125000004432 carbon atom Chemical group C* 0.000 claims description 61
150000001413 amino acids Chemical class 0.000 claims description 51
125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 48
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 43
229910052799 carbon Inorganic materials 0.000 claims description 28
125000005865 C2-C10alkynyl group Chemical group 0.000 claims description 27
239000003795 chemical substances by application Substances 0.000 claims description 27
230000036757 core body temperature Effects 0.000 claims description 22
125000002950 monocyclic group Chemical group 0.000 claims description 20
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 19
230000001939 inductive effect Effects 0.000 claims description 19
229910052757 nitrogen Inorganic materials 0.000 claims description 18
CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 claims description 17
230000036284 oxygen consumption Effects 0.000 claims description 17
LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 claims description 16
125000000753 cycloalkyl group Chemical group 0.000 claims description 15
125000004433 nitrogen atom Chemical group N* 0.000 claims description 12
125000002619 bicyclic group Chemical group 0.000 claims description 11
125000000732 arylene group Chemical group 0.000 claims description 10
208000037891 myocardial injury Diseases 0.000 claims description 9
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 8
208000025966 Neurological disease Diseases 0.000 claims description 6
230000004060 metabolic process Effects 0.000 claims description 6
125000006370 trihalo methyl group Chemical group 0.000 claims description 2
230000017105 transposition Effects 0.000 claims 1
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OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 69
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229910019142 PO4 Inorganic materials 0.000 description 28
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125000004122 cyclic group Chemical group 0.000 description 26
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QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical compound CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 description 21
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FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 14
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238000002347 injection Methods 0.000 description 13
239000007924 injection Substances 0.000 description 13
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HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 12
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MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 7
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