BRPI0709124A2

BRPI0709124A2 - composto purina e métodos de uso dos mesmos

composto purina e métodos de uso dos mesmos Download PDF

Info

Publication number: BRPI0709124A2
Authority: BR; Brazil
Prior art keywords: formula; compound; alkyl; monocyclic; bicyclic
Prior art date: 2006-03-23

Application number

BRPI0709124-9A

Other languages

English (en)

Portuguese (pt)

Inventor

Andrew L Salzman

Prakash Jagtap

Original Assignee

Inotek Pharmaceuticals Corp

Priority date

2006-03-23

Filing date

2007-03-22

Publication date

2011-06-28

2007-03-22 Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp

2011-06-28 Publication of BRPI0709124A2 publication Critical patent/BRPI0709124A2/pt

Links

-1 purine compound Chemical class 0.000 title claims abstract description 429
238000000034 method Methods 0.000 title claims abstract description 300
KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title abstract description 325
239000000203 mixture Substances 0.000 claims abstract description 110
210000002216 heart Anatomy 0.000 claims abstract description 71
230000004060 metabolic process Effects 0.000 claims abstract description 47
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 40
201000010099 disease Diseases 0.000 claims abstract description 22
208000008589 Obesity Diseases 0.000 claims abstract description 20
206010012601 diabetes mellitus Diseases 0.000 claims abstract description 20
235000020824 obesity Nutrition 0.000 claims abstract description 20
230000000302 ischemic effect Effects 0.000 claims abstract description 19
208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 16
206010063837 Reperfusion injury Diseases 0.000 claims abstract description 16
208000012902 Nervous system disease Diseases 0.000 claims abstract description 14
150000001875 compounds Chemical class 0.000 claims description 380
125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 202
125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 174
125000000217 alkyl group Chemical group 0.000 claims description 120
125000002950 monocyclic group Chemical group 0.000 claims description 113
150000003839 salts Chemical class 0.000 claims description 103
125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 99
125000002619 bicyclic group Chemical group 0.000 claims description 65
125000003118 aryl group Chemical group 0.000 claims description 61
125000004432 carbon atom Chemical group C* 0.000 claims description 57
125000000392 cycloalkenyl group Chemical group 0.000 claims description 56
125000001475 halogen functional group Chemical group 0.000 claims description 56
150000001413 amino acids Chemical class 0.000 claims description 51
229910052799 carbon Inorganic materials 0.000 claims description 45
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 42
125000004122 cyclic group Chemical group 0.000 claims description 35
125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 34
101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 claims description 33
101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 claims description 30
125000000732 arylene group Chemical group 0.000 claims description 30
239000003795 chemical substances by application Substances 0.000 claims description 28
125000005865 C2-C10alkynyl group Chemical group 0.000 claims description 27
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 19
230000001939 inductive effect Effects 0.000 claims description 18
229910052757 nitrogen Inorganic materials 0.000 claims description 18
229910052760 oxygen Inorganic materials 0.000 claims description 18
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 15
230000036284 oxygen consumption Effects 0.000 claims description 15
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 12
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125000000623 heterocyclic group Chemical group 0.000 claims description 11
125000004433 nitrogen atom Chemical group N* 0.000 claims description 9
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
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125000005843 halogen group Chemical group 0.000 claims description 8
LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 claims description 7
239000000126 substance Substances 0.000 claims description 7
125000006732 (C1-C15) alkyl group Chemical group 0.000 claims description 5
101100294103 Caenorhabditis elegans nhr-31 gene Proteins 0.000 claims description 4
CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 claims description 4
125000002947 alkylene group Chemical group 0.000 claims description 2
125000002993 cycloalkylene group Chemical group 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
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