KR20080099317A - 신경퇴행성 질환 치료를 위한 메리다마이신 유사체 - Google Patents

신경퇴행성 질환 치료를 위한 메리다마이신 유사체 Download PDF

Info

Publication number
KR20080099317A
KR20080099317A KR1020087021820A KR20087021820A KR20080099317A KR 20080099317 A KR20080099317 A KR 20080099317A KR 1020087021820 A KR1020087021820 A KR 1020087021820A KR 20087021820 A KR20087021820 A KR 20087021820A KR 20080099317 A KR20080099317 A KR 20080099317A
Authority
KR
South Korea
Prior art keywords
compound
alkyl
substituted
formula
heterocyclyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020087021820A
Other languages
English (en)
Korean (ko)
Inventor
에드문드 이드리스 그라지아니
케빈 퐁
Original Assignee
와이어쓰
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 와이어쓰 filed Critical 와이어쓰
Publication of KR20080099317A publication Critical patent/KR20080099317A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020087021820A 2006-03-07 2007-03-05 신경퇴행성 질환 치료를 위한 메리다마이신 유사체 Withdrawn KR20080099317A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77994006P 2006-03-07 2006-03-07
US60/779,940 2006-03-07

Publications (1)

Publication Number Publication Date
KR20080099317A true KR20080099317A (ko) 2008-11-12

Family

ID=38289934

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087021820A Withdrawn KR20080099317A (ko) 2006-03-07 2007-03-05 신경퇴행성 질환 치료를 위한 메리다마이신 유사체

Country Status (19)

Country Link
US (1) US7745457B2 (enExample)
EP (1) EP1991551A1 (enExample)
JP (1) JP2009529049A (enExample)
KR (1) KR20080099317A (enExample)
CN (1) CN101426796A (enExample)
AR (1) AR059738A1 (enExample)
AU (1) AU2007223962A1 (enExample)
BR (1) BRPI0708611A2 (enExample)
CA (1) CA2643350A1 (enExample)
CR (1) CR10272A (enExample)
EC (1) ECSP088718A (enExample)
IL (1) IL193414A0 (enExample)
MX (1) MX2008011312A (enExample)
NO (1) NO20083695L (enExample)
PE (1) PE20081550A1 (enExample)
RU (1) RU2008132779A (enExample)
TW (1) TW200804400A (enExample)
WO (1) WO2007103347A1 (enExample)
ZA (1) ZA200807678B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1828203A2 (en) * 2004-12-20 2007-09-05 Wyeth Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
RU2394036C2 (ru) * 2004-12-20 2010-07-10 Вайет Аналоги рапамицина и их применение при лечении неврологических, пролиферативных и воспалительных заболеваний

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9302016D0 (en) 1993-02-02 1993-03-17 Sandoz Ltd Compounds
GB9318144D0 (en) 1993-09-01 1993-10-20 Sandoz Ltd Organic compounds
EP0729471A1 (en) 1993-11-19 1996-09-04 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US20050197356A1 (en) * 2004-03-02 2005-09-08 Wyeth Non-immunosuppressive immunophilin ligands as neuroprotective and/or neuroregenerative agents
BRPI0508224A (pt) 2004-03-02 2007-07-17 Wyeth Corp composto ou um sal farmaceuticamente aceitável do mesmo, cepa de actinomiceto, isolado de uma cepa, métodos para a produção de um macrolìdeo e de um composto, produto, composição, métodos de tratamento de um mamìfero e de um distúrbio neurológico, e, uso de um composto
JP2008501342A (ja) 2004-06-03 2008-01-24 ワイス 複合ポリケチドを生成するための生合成遺伝子クラスター
US7595187B2 (en) * 2004-11-12 2009-09-29 Wyeth Elaiophylin biosynthetic gene cluster
EP1828203A2 (en) 2004-12-20 2007-09-05 Wyeth Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
RU2394036C2 (ru) 2004-12-20 2010-07-10 Вайет Аналоги рапамицина и их применение при лечении неврологических, пролиферативных и воспалительных заболеваний

Also Published As

Publication number Publication date
ZA200807678B (en) 2009-08-26
US7745457B2 (en) 2010-06-29
AU2007223962A1 (en) 2007-09-13
RU2008132779A (ru) 2010-04-20
EP1991551A1 (en) 2008-11-19
CA2643350A1 (en) 2007-09-13
CR10272A (es) 2008-10-03
MX2008011312A (es) 2008-09-12
US20070213525A1 (en) 2007-09-13
WO2007103347A1 (en) 2007-09-13
ECSP088718A (es) 2008-10-31
BRPI0708611A2 (pt) 2011-06-07
TW200804400A (en) 2008-01-16
NO20083695L (no) 2008-10-03
CN101426796A (zh) 2009-05-06
PE20081550A1 (es) 2008-12-31
IL193414A0 (en) 2009-05-04
AR059738A1 (es) 2008-04-23
JP2009529049A (ja) 2009-08-13

Similar Documents

Publication Publication Date Title
CN109963844B (zh) 一类抑制并降解酪氨酸蛋白激酶alk的化合物
US20090088448A1 (en) Rapamycin Derivatives and the Uses Thereof in the Treatment of Neurological Disorders
EA021527B1 (ru) Соединения для уменьшения продукции бета-амилоида
RU2467012C2 (ru) Способ очистки стауроспорина и способ получения n-бензоилстауроспорина
EP1181294B1 (de) Neue derivate und analoga von galanthamin
WO2018103626A1 (zh) 一类水溶性别孕烯醇酮衍生物及其用途
KR102585191B1 (ko) 신규한 벤조디아제핀-3-온 유도체 및 이를 포함하는 당뇨병성 신경병증 치료 또는 예방용 약학적 조성물
US7745457B2 (en) Meridamycin analogues for the treatment of neurodegenerative disorders
CN109422751B (zh) 一类具有降解酪氨酸蛋白激酶jak3活性的化合物
CA2380305C (fr) Derives de streptogramines, leur preparation et les compositions qui les contiennent
JP2019513151A (ja) カンプトテシン誘導体及びその使用
US20090105256A1 (en) Prodrugs of ion channel modulating compounds and uses thereof
WO2006125887A1 (fr) Composes derives de 5h-pyrido[4,3-b]indole et leurs utilisations comme medicament pour traiter les maladies neurodegeneratives a polyglutamines
EP1674101B1 (fr) Dérivés cinnamates de benzo [b]pyrano[3,2-h]acridin-7-one, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
WO2025130964A1 (zh) 取代n-(4-三氟甲基)-2-氰基巴豆酰胺化合物及其制备方法、药物组合及用途
CN116120327A (zh) β-榄香烯13,14-位对称的双取代衍生物及其制备方法和应用
KR101881115B1 (ko) 신규 2-치환된 테트라하이드로피란 또는 2-치환된 테트라하이드로퓨란 유도체 화합물, 이의 제조방법 및 이의 용도
HK40087434A (zh) 新型环烯酮化合物或其盐
CN116283764A (zh) 硝羟喹啉前药及其制备方法和用途
HK40087434B (en) Novel cycloalkenone compound or salt thereof
JP2026506169A (ja) キナゾリン化合物及び使用

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20080905

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid