KR20080027462A - ２-(１ｈ-인돌릴술파닐)-아릴 아민 유도체 - Google Patents
２-(１ｈ-인돌릴술파닐)-아릴 아민 유도체 Download PDFInfo
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- KR20080027462A KR20080027462A KR1020077029334A KR20077029334A KR20080027462A KR 20080027462 A KR20080027462 A KR 20080027462A KR 1020077029334 A KR1020077029334 A KR 1020077029334A KR 20077029334 A KR20077029334 A KR 20077029334A KR 20080027462 A KR20080027462 A KR 20080027462A
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- South Korea
- Prior art keywords
- alk
- disorder
- methyl
- phenyl
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- AHKFTQMFYCGCMH-UHFFFAOYSA-N tert-butyl n-methyl-n-[2-[2-tri(propan-2-yl)silylsulfanylphenyl]ethyl]carbamate Chemical compound CC(C)[Si](C(C)C)(C(C)C)SC1=CC=CC=C1CCN(C)C(=O)OC(C)(C)C AHKFTQMFYCGCMH-UHFFFAOYSA-N 0.000 description 1
- BJYHPGZQQDSBNB-UHFFFAOYSA-N tert-butyl n-methyl-n-[3-(2-sulfanylphenyl)propyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C)CCCC1=CC=CC=C1S BJYHPGZQQDSBNB-UHFFFAOYSA-N 0.000 description 1
- JFLAFOXFVFRSRS-UHFFFAOYSA-N tert-butyl n-methyl-n-[3-[2-(1-methylindol-3-yl)sulfanylphenyl]propyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C)CCCC1=CC=CC=C1SC1=CN(C)C2=CC=CC=C12 JFLAFOXFVFRSRS-UHFFFAOYSA-N 0.000 description 1
- AADBHLUEFQMIPD-UHFFFAOYSA-N tert-butyl n-methyl-n-[3-[2-[(5-methyl-1h-indol-3-yl)sulfanyl]phenyl]propyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C)CCCC1=CC=CC=C1SC1=CNC2=CC=C(C)C=C12 AADBHLUEFQMIPD-UHFFFAOYSA-N 0.000 description 1
- YGVSTLVFQRTVII-UHFFFAOYSA-N tert-butyl n-methyl-n-[3-[2-[(6-methylsulfonyl-1h-indol-3-yl)sulfanyl]phenyl]propyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C)CCCC1=CC=CC=C1SC1=CNC2=CC(S(C)(=O)=O)=CC=C12 YGVSTLVFQRTVII-UHFFFAOYSA-N 0.000 description 1
- CLXGIZCVZDZGBP-UHFFFAOYSA-N tert-butyl n-methyl-n-[3-[2-[(7-nitro-1h-indol-3-yl)sulfanyl]phenyl]propyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C)CCCC1=CC=CC=C1SC1=CNC2=C([N+]([O-])=O)C=CC=C12 CLXGIZCVZDZGBP-UHFFFAOYSA-N 0.000 description 1
- HLJUJEOANJOUQA-UHFFFAOYSA-N tert-butyl n-methyl-n-[3-[2-tri(propan-2-yl)silylsulfanylphenyl]propyl]carbamate Chemical compound CC(C)[Si](C(C)C)(C(C)C)SC1=CC=CC=C1CCCN(C)C(=O)OC(C)(C)C HLJUJEOANJOUQA-UHFFFAOYSA-N 0.000 description 1
- AVHYWPVUUNHCPI-UHFFFAOYSA-N tert-butyl n-methyl-n-[4-(2-sulfanylphenyl)butyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C)CCCCC1=CC=CC=C1S AVHYWPVUUNHCPI-UHFFFAOYSA-N 0.000 description 1
- WXWUGRRPNCVVHP-UHFFFAOYSA-N tert-butyl n-methyl-n-[4-[2-(1-methylindol-3-yl)sulfanylphenyl]butyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C)CCCCC1=CC=CC=C1SC1=CN(C)C2=CC=CC=C12 WXWUGRRPNCVVHP-UHFFFAOYSA-N 0.000 description 1
- PLZUNTGTKIMDBH-UHFFFAOYSA-N tert-butyl n-methyl-n-[4-[2-tri(propan-2-yl)silylsulfanylphenyl]butyl]carbamate Chemical compound CC(C)[Si](C(C)C)(C(C)C)SC1=CC=CC=C1CCCCN(C)C(=O)OC(C)(C)C PLZUNTGTKIMDBH-UHFFFAOYSA-N 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical class C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- CPKHFNMJTBLKLK-UHFFFAOYSA-N tri(propan-2-yl)-sulfanylsilane Chemical compound CC(C)[Si](S)(C(C)C)C(C)C CPKHFNMJTBLKLK-UHFFFAOYSA-N 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 229950002929 trinitrophenol Drugs 0.000 description 1
- 239000003174 triple reuptake inhibitor Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229940009065 wellbutrin Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69200905P | 2005-06-17 | 2005-06-17 | |
| US60/692,009 | 2005-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080027462A true KR20080027462A (ko) | 2008-03-27 |
Family
ID=37532681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077029334A Withdrawn KR20080027462A (ko) | 2005-06-17 | 2006-06-14 | ２-(１ｈ-인돌릴술파닐)-아릴 아민 유도체 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1893575B1 (enExample) |
| JP (1) | JP5144507B2 (enExample) |
| KR (1) | KR20080027462A (enExample) |
| CN (1) | CN101238101A (enExample) |
| AR (1) | AR054394A1 (enExample) |
| AU (1) | AU2006257288A1 (enExample) |
| BR (1) | BRPI0611748A2 (enExample) |
| CA (1) | CA2611566C (enExample) |
| EA (1) | EA200800070A1 (enExample) |
| ES (1) | ES2616095T3 (enExample) |
| IL (1) | IL188064A0 (enExample) |
| MX (1) | MX2007014954A (enExample) |
| NO (1) | NO20080265L (enExample) |
| WO (1) | WO2006134499A2 (enExample) |
| ZA (1) | ZA200710885B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100286226A1 (en) * | 2007-09-24 | 2010-11-11 | H. Lundbeck A/S | Combination therapy related to serotonin dual action compounds |
| TW200938189A (en) * | 2008-03-13 | 2009-09-16 | Lundbeck & Co As H | [2-(6-flouro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders |
| US9000025B2 (en) | 2010-08-20 | 2015-04-07 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
| US9260416B2 (en) | 2011-05-27 | 2016-02-16 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| ES2687481T3 (es) * | 2013-03-15 | 2018-10-25 | Chromocell Corporation | Moduladores del canal de sodio para el tratamiento del dolor |
| EP3046909A4 (en) | 2013-09-17 | 2017-03-29 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| US9714240B2 (en) | 2013-09-17 | 2017-07-25 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| JP2016531874A (ja) | 2013-09-26 | 2016-10-13 | ファーマケア，インク． | オートタキシン阻害剤化合物 |
| CA2930737C (en) | 2013-11-22 | 2023-02-21 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| SG10201911204WA (en) | 2015-05-27 | 2020-02-27 | Pharmakea Inc | Autotaxin inhibitors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117129A (en) * | 1976-10-22 | 1978-09-26 | Warner-Lambert Company | Indolobenzoxazepines as cns depressants |
| ES2128281T1 (es) * | 1995-11-06 | 1999-05-16 | Gist Brocades Bv | Proceso de desesterificacion. |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| TW200400177A (en) * | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| JP4090491B2 (ja) * | 2003-12-23 | 2008-05-28 | ハー・ルンドベック・アクチエゼルスカベット | ２−（１ｈ−インドリルスルファニル）−ベンジルアミン誘導体 |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
-
2006
- 2006-06-13 AR ARP060102491A patent/AR054394A1/es not_active Application Discontinuation
- 2006-06-14 JP JP2008516452A patent/JP5144507B2/ja not_active Expired - Fee Related
- 2006-06-14 WO PCT/IB2006/002785 patent/WO2006134499A2/en not_active Ceased
- 2006-06-14 CN CNA2006800218382A patent/CN101238101A/zh active Pending
- 2006-06-14 CA CA2611566A patent/CA2611566C/en not_active Expired - Fee Related
- 2006-06-14 MX MX2007014954A patent/MX2007014954A/es not_active Application Discontinuation
- 2006-06-14 KR KR1020077029334A patent/KR20080027462A/ko not_active Withdrawn
- 2006-06-14 EP EP06808965.5A patent/EP1893575B1/en active Active
- 2006-06-14 AU AU2006257288A patent/AU2006257288A1/en not_active Abandoned
- 2006-06-14 ES ES06808965.5T patent/ES2616095T3/es active Active
- 2006-06-14 EA EA200800070A patent/EA200800070A1/ru unknown
- 2006-06-14 ZA ZA200710885A patent/ZA200710885B/xx unknown
- 2006-06-14 BR BRPI0611748A patent/BRPI0611748A2/pt not_active IP Right Cessation
-
2007
- 2007-12-11 IL IL188064A patent/IL188064A0/en unknown
-
2008
- 2008-01-15 NO NO20080265A patent/NO20080265L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007014954A (es) | 2008-02-15 |
| EP1893575A2 (en) | 2008-03-05 |
| WO2006134499A2 (en) | 2006-12-21 |
| JP5144507B2 (ja) | 2013-02-13 |
| ZA200710885B (en) | 2009-03-25 |
| BRPI0611748A2 (pt) | 2016-11-22 |
| AR054394A1 (es) | 2007-06-20 |
| NO20080265L (no) | 2008-01-15 |
| JP2008546679A (ja) | 2008-12-25 |
| ES2616095T3 (es) | 2017-06-09 |
| EP1893575B1 (en) | 2017-01-11 |
| IL188064A0 (en) | 2008-03-20 |
| CN101238101A (zh) | 2008-08-06 |
| AU2006257288A1 (en) | 2006-12-21 |
| EA200800070A1 (ru) | 2008-04-28 |
| WO2006134499A3 (en) | 2007-04-12 |
| CA2611566A1 (en) | 2006-12-21 |
| CA2611566C (en) | 2011-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20071214 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |