KR20080021636A - Ｇｌｐ-1 아고니스트인 신규 화합물 - Google Patents

Ｇｌｐ-1 아고니스트인 신규 화합물 Download PDF

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Publication number
KR20080021636A
KR20080021636A KR1020077028300A KR20077028300A KR20080021636A KR 20080021636 A KR20080021636 A KR 20080021636A KR 1020077028300 A KR1020077028300 A KR 1020077028300A KR 20077028300 A KR20077028300 A KR 20077028300A KR 20080021636 A KR20080021636 A KR 20080021636A
Authority
KR
South Korea
Prior art keywords
group
amino acid
alkyl
glp
bip
Prior art date
Application number
KR1020077028300A
Other languages
English (en)
Korean (ko)
Inventor
브라즈 부샨 로흐라이
비드야 부샨 로흐라이
라제쉬 에이치. 바헤카르
Original Assignee
카딜라 핼쓰캐어 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 카딜라 핼쓰캐어 리미티드 filed Critical 카딜라 핼쓰캐어 리미티드
Publication of KR20080021636A publication Critical patent/KR20080021636A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020077028300A 2005-05-05 2006-05-04 Ｇｌｐ-1 아고니스트인 신규 화합물 KR20080021636A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN558/MUM/2005 2005-05-05
IN558MU2005 2005-05-05
IN645MU2005 2005-05-31
IN645/MUM/2005 2005-05-31

Publications (1)

Publication Number Publication Date
KR20080021636A true KR20080021636A (ko) 2008-03-07

Family

ID=37727716

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077028300A KR20080021636A (ko) 2005-05-05 2006-05-04 Ｇｌｐ-1 아고니스트인 신규 화합물

Country Status (12)

Country Link
EP (1) EP1891106A2 (fr)
JP (1) JP2008540402A (fr)
KR (1) KR20080021636A (fr)
AP (1) AP2007004227A0 (fr)
AU (1) AU2006277557A1 (fr)
BR (1) BRPI0612471A2 (fr)
CA (1) CA2606894A1 (fr)
EA (1) EA200702419A1 (fr)
IL (1) IL187105A0 (fr)
MX (1) MX2007013655A (fr)
NO (1) NO20075618L (fr)
WO (1) WO2007017892A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
US20100022457A1 (en) 2006-05-26 2010-01-28 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators
AU2007323035B2 (en) * 2006-10-03 2011-11-24 Cadila Healthcare Limited Antidiabetic compounds
RU2010128247A (ru) * 2007-12-11 2012-01-20 Ф.Хоффманн-Ля Рош Аг (Ch) Синтез инсулинотропных пептидов с помощью комбинированных твердофазных и растворных методик
MX2010006287A (es) * 2007-12-11 2010-10-26 Cadila Healthcare Ltd Peptidomimeticos con actividades antagonistas de glucagon y agonistas del peptido 1 similar al glucagon.
SG175411A1 (en) * 2009-05-01 2011-12-29 Hoffmann La Roche Insulinotropic peptide synthesis using solid and solution phase combination techniques
CN101891823B (zh) 2010-06-11 2012-10-03 北京东方百泰生物科技有限公司 一种Exendin-4及其类似物融合蛋白
JP6480872B2 (ja) 2013-02-15 2019-03-13 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ インスリン分泌性ポリペプチド

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545618A (en) * 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
GB0024428D0 (en) * 2000-10-05 2000-11-22 King S College Absorption enhancers
AU2002317599B2 (en) * 2001-07-31 2008-04-03 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services GLP-1 exendin-4 peptide analogs and uses thereof
US7238671B2 (en) * 2001-10-18 2007-07-03 Bristol-Myers Squibb Company Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
WO2003058203A2 (fr) * 2002-01-08 2003-07-17 Eli Lilly And Company Analogues de peptide-1 de type glucagon d'extension
EP1718665B1 (fr) * 2004-02-11 2013-04-10 Amylin Pharmaceuticals, LLC Polypeptides hybrides presentant des proprietes pouvant etre choisies
TW200611704A (en) * 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
DE102004043153B4 (de) * 2004-09-03 2013-11-21 Philipps-Universität Marburg Erfindung betreffend GLP-1 und Exendin

Also Published As

Publication number Publication date
EP1891106A2 (fr) 2008-02-27
MX2007013655A (es) 2008-01-24
JP2008540402A (ja) 2008-11-20
AP2007004227A0 (en) 2007-12-31
WO2007017892A2 (fr) 2007-02-15
EA200702419A1 (ru) 2008-04-28
CA2606894A1 (fr) 2007-02-15
IL187105A0 (en) 2008-02-09
WO2007017892A3 (fr) 2007-09-20
NO20075618L (no) 2008-01-30
BRPI0612471A2 (pt) 2016-09-06
AU2006277557A1 (en) 2007-02-15

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