WO2007017892A3 - Nouveaux composes utilises en tant qu'agonistes de glp-i - Google Patents

Nouveaux composes utilises en tant qu'agonistes de glp-i Download PDF

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Publication number
WO2007017892A3
WO2007017892A3 PCT/IN2006/000154 IN2006000154W WO2007017892A3 WO 2007017892 A3 WO2007017892 A3 WO 2007017892A3 IN 2006000154 W IN2006000154 W IN 2006000154W WO 2007017892 A3 WO2007017892 A3 WO 2007017892A3
Authority
WO
WIPO (PCT)
Prior art keywords
glp
agonists
novel compounds
compounds
diabetes
Prior art date
Application number
PCT/IN2006/000154
Other languages
English (en)
Other versions
WO2007017892A2 (fr
Inventor
Braj Bhushan Lohray
Vidya Bhushan Lohray
Rajesh H Bahekar
Original Assignee
Cadila Healthcare Ltd
Braj Bhushan Lohray
Vidya Bhushan Lohray
Rajesh H Bahekar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2008509578A priority Critical patent/JP2008540402A/ja
Priority to CA002606894A priority patent/CA2606894A1/fr
Priority to MX2007013655A priority patent/MX2007013655A/es
Priority to AP2007004227A priority patent/AP2007004227A0/xx
Priority to BRPI0612471A priority patent/BRPI0612471A2/pt
Priority to AU2006277557A priority patent/AU2006277557A1/en
Application filed by Cadila Healthcare Ltd, Braj Bhushan Lohray, Vidya Bhushan Lohray, Rajesh H Bahekar filed Critical Cadila Healthcare Ltd
Priority to EA200702419A priority patent/EA200702419A1/ru
Priority to EP06809915A priority patent/EP1891106A2/fr
Publication of WO2007017892A2 publication Critical patent/WO2007017892A2/fr
Publication of WO2007017892A3 publication Critical patent/WO2007017892A3/fr
Priority to IL187105A priority patent/IL187105A0/en
Priority to NO20075618A priority patent/NO20075618L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un groupe de nouveaux peptidomimétiques utiles pour le traitement du diabète. Ces composés sont représentés par la formule générale (I) suivante : A-X1- S1-Y-S2-X2-B.
PCT/IN2006/000154 2005-05-05 2006-05-04 Nouveaux composes utilises en tant qu'agonistes de glp-i WO2007017892A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA002606894A CA2606894A1 (fr) 2005-05-05 2006-05-04 Nouveaux composes utilises en tant qu'agonistes de glp-i
MX2007013655A MX2007013655A (es) 2005-05-05 2006-05-04 Nuevos compuestos como agonistas glp-i.
AP2007004227A AP2007004227A0 (en) 2005-05-05 2006-05-04 Novel compounds as GLP-1 agonists
BRPI0612471A BRPI0612471A2 (pt) 2005-05-05 2006-05-04 novos compostos como agonistas glp-1
AU2006277557A AU2006277557A1 (en) 2005-05-05 2006-05-04 Novel compounds as GPL-I agonists
JP2008509578A JP2008540402A (ja) 2005-05-05 2006-05-04 Ｇｌｐ−１アゴニストとしての新規な化合物
EA200702419A EA200702419A1 (ru) 2005-05-05 2006-05-04 Новые соединения как агонисты glp-1
EP06809915A EP1891106A2 (fr) 2005-05-05 2006-05-04 Nouveaux composes utilises en tant qu'agonistes de glp-i
IL187105A IL187105A0 (en) 2005-05-05 2007-11-01 Novel compunds as glp-i agonists
NO20075618A NO20075618L (no) 2005-05-05 2007-11-06 Novel compounds as GLP-1 Agonists

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN558/MUM/2005 2005-05-05
IN558MU2005 2005-05-05
IN645/MUM/2005 2005-05-31
IN645MU2005 2005-05-31

Publications (2)

Publication Number Publication Date
WO2007017892A2 WO2007017892A2 (fr) 2007-02-15
WO2007017892A3 true WO2007017892A3 (fr) 2007-09-20

Family

ID=37727716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000154 WO2007017892A2 (fr) 2005-05-05 2006-05-04 Nouveaux composes utilises en tant qu'agonistes de glp-i

Country Status (12)

Country Link
EP (1) EP1891106A2 (fr)
JP (1) JP2008540402A (fr)
KR (1) KR20080021636A (fr)
AP (1) AP2007004227A0 (fr)
AU (1) AU2006277557A1 (fr)
BR (1) BRPI0612471A2 (fr)
CA (1) CA2606894A1 (fr)
EA (1) EA200702419A1 (fr)
IL (1) IL187105A0 (fr)
MX (1) MX2007013655A (fr)
NO (1) NO20075618L (fr)
WO (1) WO2007017892A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
US20100022457A1 (en) 2006-05-26 2010-01-28 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators
EP2084182B1 (fr) * 2006-10-03 2013-08-28 Cadila Healthcare Limited Composés antidiabétiques
KR101277560B1 (ko) * 2007-12-11 2013-06-25 카딜라 핼쓰캐어 리미티드 글루카곤 안타고니스트 활성 및 ｇｌｐ-1 아고니스트 활성의 펩티드 유사체
CN101903400B (zh) * 2007-12-11 2013-12-18 霍夫曼-拉罗奇有限公司 使用固相和液相组合技术的促胰岛素肽合成
CN102414220A (zh) * 2009-05-01 2012-04-11 霍夫曼-拉罗奇有限公司 使用固相和液相组合技术的促胰岛素肽合成
CN101891823B (zh) 2010-06-11 2012-10-03 北京东方百泰生物科技有限公司 一种Exendin-4及其类似物融合蛋白
WO2014127120A1 (fr) 2013-02-15 2014-08-21 Mayo Foundation For Medical Education And Research Polypeptides sécréteurs d'insuline

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545618A (en) * 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
WO2002028438A1 (fr) * 2000-10-05 2002-04-11 King's College London Lipopeptides activateurs d'absorption pour composes bio-actifs
WO2003011892A2 (fr) * 2001-07-31 2003-02-13 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Glp-1, exendine-4, analogues peptidiques et utilisations associees
WO2003058203A2 (fr) * 2002-01-08 2003-07-17 Eli Lilly And Company Analogues de peptide-1 de type glucagon d'extension
WO2004094461A2 (fr) * 2003-04-21 2004-11-04 Bristol-Myers Squibb Company Mimetiques du peptide 1 de type glucagon humain utilises dans le traitement du diabete et des pathologies apparentees
WO2005077072A2 (fr) * 2004-02-11 2005-08-25 Amylin Pharmaceuticals, Inc. Polypeptides hybrides presentant des proprietes pouvant etre choisies
WO2006014287A1 (fr) * 2004-07-02 2006-02-09 Bristol-Myers Squibb Company Modulateurs de glp-1 humain 1 et leur utilisation pour le traitement du diabète et de conditions connexes
WO2006024275A2 (fr) * 2004-09-03 2006-03-09 Philipps-Universität Marburg Invention concernant le glp-1 et l'exendine

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545618A (en) * 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
WO2002028438A1 (fr) * 2000-10-05 2002-04-11 King's College London Lipopeptides activateurs d'absorption pour composes bio-actifs
WO2003011892A2 (fr) * 2001-07-31 2003-02-13 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Glp-1, exendine-4, analogues peptidiques et utilisations associees
WO2003058203A2 (fr) * 2002-01-08 2003-07-17 Eli Lilly And Company Analogues de peptide-1 de type glucagon d'extension
WO2004094461A2 (fr) * 2003-04-21 2004-11-04 Bristol-Myers Squibb Company Mimetiques du peptide 1 de type glucagon humain utilises dans le traitement du diabete et des pathologies apparentees
WO2005077072A2 (fr) * 2004-02-11 2005-08-25 Amylin Pharmaceuticals, Inc. Polypeptides hybrides presentant des proprietes pouvant etre choisies
WO2006014287A1 (fr) * 2004-07-02 2006-02-09 Bristol-Myers Squibb Company Modulateurs de glp-1 humain 1 et leur utilisation pour le traitement du diabète et de conditions connexes
WO2006024275A2 (fr) * 2004-09-03 2006-03-09 Philipps-Universität Marburg Invention concernant le glp-1 et l'exendine

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AL-SABAH SULEIMAN ET AL: "A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 140, no. 2, September 2003 (2003-09-01), pages 339 - 346, XP002437826, ISSN: 0007-1188 *
CHAHRZAD MONTROSE-RAFIZADEH ET AL: "High Potency Antagonists of the Pancreatic Glucagon-like Peptide-1 Receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 272, no. 34, 22 August 1997 (1997-08-22), pages 21201 - 21206, XP002247450, ISSN: 0021-9258 *
DOYLE MAIRE E ET AL: "The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity.", REGULATORY PEPTIDES, vol. 114, no. 2-3, 15 July 2003 (2003-07-15), pages 153 - 158, XP002441636, ISSN: 0167-0115 *
GREEN B D ET AL: "STRUCTURALLY MODIFIED ANALOGUES OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) AND GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) AS FUTURE ANTIDIABETIC AGENTS", CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBLISHERS, SCHIPHOL, NL, vol. 10, no. 29, 2004, pages 3651 - 3662, XP009068381, ISSN: 1381-6128 *
HINKE SIMON A ET AL: "In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide", LIFE SCIENCES, PERGAMON PRESS, OXFORD, GB, vol. 75, no. 15, 27 August 2004 (2004-08-27), pages 1857 - 1870, XP002387302, ISSN: 0024-3205 *
RUNGE S ET AL: "Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity.", BRITISH JOURNAL OF PHARMACOLOGY, vol. 138, no. 5, March 2003 (2003-03-01), pages 787 - 794, XP002427759, ISSN: 0007-1188 *
XIAO Q ET AL: "Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 40, no. 9, 6 March 2001 (2001-03-06), pages 2860 - 2869, XP002277645, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
EP1891106A2 (fr) 2008-02-27
WO2007017892A2 (fr) 2007-02-15
AU2006277557A1 (en) 2007-02-15
BRPI0612471A2 (pt) 2016-09-06
EA200702419A1 (ru) 2008-04-28
NO20075618L (no) 2008-01-30
AP2007004227A0 (en) 2007-12-31
CA2606894A1 (fr) 2007-02-15
KR20080021636A (ko) 2008-03-07
JP2008540402A (ja) 2008-11-20
MX2007013655A (es) 2008-01-24
IL187105A0 (en) 2008-02-09

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