MX2010006287A - Peptidomimeticos con actividades antagonistas de glucagon y agonistas del peptido 1 similar al glucagon. - Google Patents
Peptidomimeticos con actividades antagonistas de glucagon y agonistas del peptido 1 similar al glucagon.Info
- Publication number
- MX2010006287A MX2010006287A MX2010006287A MX2010006287A MX2010006287A MX 2010006287 A MX2010006287 A MX 2010006287A MX 2010006287 A MX2010006287 A MX 2010006287A MX 2010006287 A MX2010006287 A MX 2010006287A MX 2010006287 A MX2010006287 A MX 2010006287A
- Authority
- MX
- Mexico
- Prior art keywords
- peptidomimetics
- glp
- agonistic activities
- glucagon antagonistic
- glucagon
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La presente invención proporciona peptidomiméticos novedosos de fórmula (I), que actúan principalmente como secretagogos de la insulina dependientes de la glucosa. Además, se encontró que estos peptidomiméticos muestran actividad antagonista del receptor del glucagon, junto con la actividad agonista del receptor de GLP-1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2420MU2007 | 2007-12-11 | ||
IN1696MU2008 | 2008-08-11 | ||
PCT/IN2008/000831 WO2009125424A2 (en) | 2007-12-11 | 2008-12-10 | Peptidomimetics with glucagon antagonistic and glp-1 agonistic activities |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010006287A true MX2010006287A (es) | 2010-10-26 |
Family
ID=41066190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010006287A MX2010006287A (es) | 2007-12-11 | 2008-12-10 | Peptidomimeticos con actividades antagonistas de glucagon y agonistas del peptido 1 similar al glucagon. |
Country Status (15)
Country | Link |
---|---|
US (1) | US8883963B2 (es) |
EP (1) | EP2231701B1 (es) |
JP (1) | JP5270687B2 (es) |
KR (1) | KR101277560B1 (es) |
AT (1) | ATE554098T1 (es) |
CA (1) | CA2707448C (es) |
DK (1) | DK2231701T3 (es) |
EA (1) | EA018000B1 (es) |
ES (1) | ES2382579T3 (es) |
IL (1) | IL206252A0 (es) |
MX (1) | MX2010006287A (es) |
NI (1) | NI201000095A (es) |
PT (1) | PT2231701E (es) |
WO (1) | WO2009125424A2 (es) |
ZA (1) | ZA201003804B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120264685A1 (en) | 2009-10-22 | 2012-10-18 | Rajesh Bahekar | Short chain peptidomimetics based orally active glp 1 agonist and glucagon receptor antagonist |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
DE102010015123A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi-Aventis Deutschland Gmbh | Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
NZ611529A (en) | 2010-12-23 | 2015-06-26 | Pfizer | Glucagon receptor modulators |
CN104744370A (zh) | 2011-02-08 | 2015-07-01 | 辉瑞大药厂 | 胰高血糖素受体调节剂 |
ES2550345T3 (es) | 2011-07-22 | 2015-11-06 | Pfizer Inc. | Moduladores del receptor de quinolinilglucagón |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
AR092873A1 (es) * | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
IN2015DN03795A (es) | 2012-10-24 | 2015-10-02 | Inserm Inst Nat De La Santé Et De La Rech Médicale | |
BR112016013157A2 (pt) * | 2013-12-13 | 2017-09-26 | Medimmune Ltd | peptídeos resistentes à protease |
WO2015168135A1 (en) * | 2014-04-28 | 2015-11-05 | The Trustees Of The University Of Pennsylvania | Novel thioamide-modified peptides and uses thereof |
US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
TWI726889B (zh) | 2015-06-10 | 2021-05-11 | 英商梅迪繆思有限公司 | 蛋白酶抗性之脂化肽 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR036711A1 (es) * | 2001-10-05 | 2004-09-29 | Bayer Corp | Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico |
CA2463908A1 (en) * | 2001-10-18 | 2003-04-24 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
AP2007004227A0 (en) * | 2005-05-05 | 2007-12-31 | Cadila Healthcare Ltd | Novel compounds as GLP-1 agonists |
JP2008539735A (ja) * | 2005-05-06 | 2008-11-20 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | グルカゴン様ペプチド1(glp−1)受容体アンタゴニストおよびそれらの薬理学的使用方法 |
EP1976873A2 (en) * | 2006-01-11 | 2008-10-08 | Brystol-Myers Squibb Company | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
US20100022457A1 (en) * | 2006-05-26 | 2010-01-28 | Bristol-Myers Squibb Company | Sustained release glp-1 receptor modulators |
EP2084182B1 (en) * | 2006-10-03 | 2013-08-28 | Cadila Healthcare Limited | Antidiabetic compounds |
-
2008
- 2008-12-10 KR KR1020107013903A patent/KR101277560B1/ko not_active IP Right Cessation
- 2008-12-10 US US12/746,536 patent/US8883963B2/en not_active Expired - Fee Related
- 2008-12-10 AT AT08873860T patent/ATE554098T1/de active
- 2008-12-10 EP EP08873860A patent/EP2231701B1/en active Active
- 2008-12-10 WO PCT/IN2008/000831 patent/WO2009125424A2/en active Application Filing
- 2008-12-10 DK DK08873860.4T patent/DK2231701T3/da active
- 2008-12-10 MX MX2010006287A patent/MX2010006287A/es active IP Right Grant
- 2008-12-10 JP JP2010537603A patent/JP5270687B2/ja not_active Expired - Fee Related
- 2008-12-10 EA EA201070722A patent/EA018000B1/ru not_active IP Right Cessation
- 2008-12-10 ES ES08873860T patent/ES2382579T3/es active Active
- 2008-12-10 PT PT08873860T patent/PT2231701E/pt unknown
- 2008-12-10 CA CA2707448A patent/CA2707448C/en not_active Expired - Fee Related
-
2010
- 2010-05-27 ZA ZA2010/03804A patent/ZA201003804B/en unknown
- 2010-06-08 IL IL206252A patent/IL206252A0/en not_active IP Right Cessation
- 2010-06-09 NI NI201000095A patent/NI201000095A/es unknown
Also Published As
Publication number | Publication date |
---|---|
PT2231701E (pt) | 2012-05-28 |
NI201000095A (es) | 2011-05-04 |
ES2382579T3 (es) | 2012-06-11 |
KR20100101110A (ko) | 2010-09-16 |
EP2231701B1 (en) | 2012-04-18 |
DK2231701T3 (da) | 2012-05-21 |
CA2707448A1 (en) | 2009-10-15 |
IL206252A0 (en) | 2010-12-30 |
ATE554098T1 (de) | 2012-05-15 |
US8883963B2 (en) | 2014-11-11 |
ZA201003804B (en) | 2011-01-26 |
JP2011506428A (ja) | 2011-03-03 |
KR101277560B1 (ko) | 2013-06-25 |
EA018000B1 (ru) | 2013-04-30 |
WO2009125424A3 (en) | 2009-12-23 |
EA201070722A1 (ru) | 2010-12-30 |
WO2009125424A2 (en) | 2009-10-15 |
CA2707448C (en) | 2014-10-14 |
US20120021972A1 (en) | 2012-01-26 |
EP2231701A2 (en) | 2010-09-29 |
JP5270687B2 (ja) | 2013-08-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |