KR20080020638A - β-아드레날린 수용체 키나제 1의 억제제로서의피라졸로피리딘 유도체 - Google Patents
β-아드레날린 수용체 키나제 1의 억제제로서의피라졸로피리딘 유도체 Download PDFInfo
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- KR20080020638A KR20080020638A KR1020077030289A KR20077030289A KR20080020638A KR 20080020638 A KR20080020638 A KR 20080020638A KR 1020077030289 A KR1020077030289 A KR 1020077030289A KR 20077030289 A KR20077030289 A KR 20077030289A KR 20080020638 A KR20080020638 A KR 20080020638A
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- alkyl
- alkylene
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- 238000000034 method Methods 0.000 claims description 17
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- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 8
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05013774.4 | 2005-06-27 | ||
| EP05013774 | 2005-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080020638A true KR20080020638A (ko) | 2008-03-05 |
Family
ID=35395578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077030289A Withdrawn KR20080020638A (ko) | 2005-06-27 | 2006-06-13 | β-아드레날린 수용체 키나제 1의 억제제로서의피라졸로피리딘 유도체 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7910602B2 (https=) |
| EP (1) | EP1899333B1 (https=) |
| JP (1) | JP5010594B2 (https=) |
| KR (1) | KR20080020638A (https=) |
| CN (1) | CN101208340B (https=) |
| AR (1) | AR054514A1 (https=) |
| AT (1) | ATE423118T1 (https=) |
| AU (1) | AU2006264044A1 (https=) |
| BR (1) | BRPI0612320A2 (https=) |
| CA (1) | CA2611296A1 (https=) |
| CY (1) | CY1110464T1 (https=) |
| DE (1) | DE602006005242D1 (https=) |
| DK (1) | DK1899333T3 (https=) |
| ES (1) | ES2322197T3 (https=) |
| HR (1) | HRP20090244T2 (https=) |
| IL (1) | IL188381A0 (https=) |
| MA (1) | MA29498B1 (https=) |
| MX (1) | MX2007015829A (https=) |
| MY (1) | MY139016A (https=) |
| NO (1) | NO20080392L (https=) |
| NZ (1) | NZ564757A (https=) |
| PL (1) | PL1899333T3 (https=) |
| PT (1) | PT1899333E (https=) |
| RS (1) | RS50821B (https=) |
| RU (1) | RU2415855C2 (https=) |
| SI (1) | SI1899333T1 (https=) |
| TW (1) | TW200800982A (https=) |
| UY (1) | UY29632A1 (https=) |
| WO (1) | WO2007000241A1 (https=) |
| ZA (1) | ZA200709853B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200815438A (en) | 2006-06-13 | 2008-04-01 | Bayer Schering Pharma Ag | Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
| US20110009421A1 (en) * | 2008-02-27 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
| US9321787B2 (en) * | 2011-07-07 | 2016-04-26 | Sanofi | Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ａｍｐｋを活性化させるインダゾール化合物 |
| GB201410815D0 (en) * | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven | Therapeutic agents |
| CN112955450A (zh) * | 2018-10-24 | 2021-06-11 | 百时美施贵宝公司 | 经取代的吲哚和吲唑化合物 |
| ES2963696T3 (es) | 2018-10-24 | 2024-04-01 | Bristol Myers Squibb Co | Compuestos diméricos de indol sustituidos |
| KR102904576B1 (ko) | 2019-05-09 | 2025-12-24 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 벤즈이미다졸론 화합물 |
| EP4041730A1 (en) | 2019-10-01 | 2022-08-17 | Bristol-Myers Squibb Company | Substituted bicyclic heteroaryl compounds |
| CN114829350B (zh) | 2019-10-04 | 2024-05-28 | 百时美施贵宝公司 | 经取代的咔唑化合物 |
| WO2024137671A1 (en) * | 2022-12-20 | 2024-06-27 | Exelixis, Inc. | Compounds that inhibit pkmyt1 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995034563A1 (en) * | 1994-06-16 | 1995-12-21 | Pfizer Inc. | Pyrazolo and pyrrolopyridines |
| ATE355841T1 (de) * | 1997-12-13 | 2007-03-15 | Bristol Myers Squibb Co | Verwendung von pyrazolo ( 3,4-b) pyridin als cyclin-abhängige kinase hemmer |
| JP2002020386A (ja) * | 2000-07-07 | 2002-01-23 | Ono Pharmaceut Co Ltd | ピラゾロピリジン誘導体 |
| AU2003245700A1 (en) * | 2002-02-12 | 2003-09-04 | Glaxo Group Limited | Pyrazolopyridine derivatives |
| BR0313262A (pt) * | 2002-08-07 | 2005-07-12 | Mitsubishi Pharma Corp | Compostos de dihidropirazolpiridina |
| KR101312736B1 (ko) * | 2003-02-27 | 2013-09-27 | 팔라우 파르마 에스에이 | 피라졸로피리딘 유도체 |
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2006
- 2006-06-13 RS RSP-2009/0165A patent/RS50821B/sr unknown
- 2006-06-13 BR BRPI0612320-1A patent/BRPI0612320A2/pt not_active IP Right Cessation
- 2006-06-13 ES ES06754324T patent/ES2322197T3/es active Active
- 2006-06-13 AT AT06754324T patent/ATE423118T1/de not_active IP Right Cessation
- 2006-06-13 DK DK06754324T patent/DK1899333T3/da active
- 2006-06-13 DE DE602006005242T patent/DE602006005242D1/de active Active
- 2006-06-13 CA CA002611296A patent/CA2611296A1/en not_active Abandoned
- 2006-06-13 EP EP06754324A patent/EP1899333B1/en active Active
- 2006-06-13 RU RU2008102970/04A patent/RU2415855C2/ru not_active IP Right Cessation
- 2006-06-13 AU AU2006264044A patent/AU2006264044A1/en not_active Abandoned
- 2006-06-13 NZ NZ564757A patent/NZ564757A/en not_active IP Right Cessation
- 2006-06-13 KR KR1020077030289A patent/KR20080020638A/ko not_active Withdrawn
- 2006-06-13 MX MX2007015829A patent/MX2007015829A/es active IP Right Grant
- 2006-06-13 PL PL06754324T patent/PL1899333T3/pl unknown
- 2006-06-13 WO PCT/EP2006/005649 patent/WO2007000241A1/en not_active Ceased
- 2006-06-13 HR HR20090244T patent/HRP20090244T2/xx unknown
- 2006-06-13 CN CN200680023397XA patent/CN101208340B/zh not_active Expired - Fee Related
- 2006-06-13 PT PT06754324T patent/PT1899333E/pt unknown
- 2006-06-13 JP JP2008518660A patent/JP5010594B2/ja not_active Expired - Fee Related
- 2006-06-13 SI SI200630284T patent/SI1899333T1/sl unknown
- 2006-06-23 TW TW095122584A patent/TW200800982A/zh unknown
- 2006-06-23 AR ARP060102721A patent/AR054514A1/es not_active Application Discontinuation
- 2006-06-26 MY MYPI20063009A patent/MY139016A/en unknown
- 2006-06-27 UY UY29632A patent/UY29632A1/es not_active Application Discontinuation
-
2007
- 2007-11-15 ZA ZA200709853A patent/ZA200709853B/xx unknown
- 2007-11-30 MA MA30441A patent/MA29498B1/fr unknown
- 2007-12-20 US US11/961,282 patent/US7910602B2/en not_active Expired - Fee Related
- 2007-12-24 IL IL188381A patent/IL188381A0/en unknown
-
2008
- 2008-01-21 NO NO20080392A patent/NO20080392L/no not_active Application Discontinuation
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2009
- 2009-05-11 CY CY20091100501T patent/CY1110464T1/el unknown
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Patent event date: 20071226 Patent event code: PA01051R01D Comment text: International Patent Application |
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